TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Buhl, Eva Miriam
A1  - Draack, Sebastian
A1  - Viereck, Thilo
A1  - Frank, 
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications
JF  - IEEE Magnetic Letters
N2  - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.
Y1  - 2018
U6  - https://doi.org/10.1109/LMAG.2018.2879034
SN  - 1949-307X
VL  - 9
IS  - Article number 8519617
PB  - IEEE
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Roeth, Anjali A.J.
A1  - Eberbeck, Dietmar
A1  - Buhl, Eva Miriam
A1  - Neumann, Ulf Peter
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells
JF  - Scientific Reports
N2  - Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95% was achieved by depositing an intracellular total thermal energy with about 50% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65% after MNP were internalized inside cells.
Y1  - 2018
U6  - https://doi.org/10.1038/s41598-018-31553-9
SN  - 2045-2322
VL  - 8
IS  - 1
SP  - Article number 13210
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - CHAP
A1  - Engemann, Heiko
A1  - Wiesen, Patrick
A1  - Kallweit, Stephan
A1  - Deshpande, Harshavardhan
A1  - Schleupen, Josef
T1  - Autonomous mobile manipulation using ROS
T2  - Advances in Service and Industrial Robotics
Y1  - 2018
SN  - 978-3-319-61276-8
U6  - https://doi.org/10.1007/978-3-319-61276-8_43
N1  - International Conference on Robotics in Alpe-Adria Danube Region RAAD 2017;
Mechanisms and Machince Science book series, Vol 49.
SP  - 389
EP  - 401
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Ermolaev, A.P.
A1  - Nivokov, I.A.
A1  - Melnikova, L.I.
A1  - Kotliar, Konstantin
T1  - Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой
T1  - Comparative characteristics of the chemical composition of vitreal contents of cadaver eyes and eyes with terminal refractory glaucoma
JF  - Vestnik oftalmologii
N2  - Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP.
Y1  - 2018
U6  - https://doi.org/10.17116/oftalma2018134051195
VL  - 5
IS  - 2
SP  - 195
EP  - 201
PB  - Media Sfera
CY  - Moskau
ER  - 
TY  - CHAP
A1  - Essingholt, Felix
A1  - Meyer, Frederic
A1  - Kuhn, Peter
A1  - Schmidt, Philip
A1  - Benkner, Thorsten
A1  - Grabmaier, Anton
T1  - Non-invasive heart beat measurement using microwave resonators
T2  - Proceedings, Vol. 2, Eurosensors 2018 Conference, Graz, Austria, 9–12 September 2018
Y1  - 2018
U6  - https://doi.org/10.3390/proceedings2131002
SN  - 2504-3900
SP  - 1002
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Fabo, Sabine
T1  - Eine dekonstruktive Erinnerungsarbeit
T2  - Doris Frohnapfel, bewaffnete Götter = Doris Frohnapfel, armed gods
Y1  - 2018
SN  - 978-3-9817241-2-7
N1  - Ausstellungskatalog Galerie M29: 09.11.2018 - 15.12.2018, Köln
SP  - 31
EP  - 35
PB  - RpB Richter-Brückner
CY  - Köln
ER  - 
TY  - CHAP
A1  - Fabo, Sabine
T1  - Einsprüche gegen den informierten Himmel ; Wegsehen; Distanzschaffen, Spielen
T2  - Orbitale Irritationen / Herausgeber: REMOTEWORDS: Achim Mohné & Uta Kopp
Y1  - 2018
SN  - 978-3-86962-302-3
SP  - 20
EP  - 45
PB  - Herbert von Halem Verlag
CY  - Köln
ER  - 
TY  - CHAP
A1  - Ferrein, Alexander
A1  - Schiffer, Stefan
A1  - Kallweit, Stephan
T1  - The ROSIN Education Concept - Fostering ROS Industrial-Related Robotics Education in Europe
T2  - ROBOT 2017: Third Iberian Robotics Conference
Y1  - 2018
SN  - 978-3-319-70836-2
U6  - https://doi.org/10.1007/978-3-319-70836-2_31
N1  - Advances in Intelligent Systems and Computing, vol 694;
(AISC, volume 694)
SP  - 370
EP  - 381
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Figueroa-Miranda, Gabriela
A1  - Feng, Lingyan
A1  - Shiu, Simon Chi-Chin
A1  - Dirkzwager, Roderick Marshall
A1  - Cheung, Yee-Wai
A1  - Tanner, Julian Alexander
A1  - Schöning, Michael Josef
A1  - Offenhäusser, Andreas
A1  - Mayer, Dirk
T1  - Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability
JF  - Sensor and Actuators B: Chemical
N2  - Malaria infection remains a significant risk for much of the population of tropical and subtropical areas, particularly in developing countries. Therefore, it is of high importance to develop sensitive, accurate and inexpensive malaria diagnosis tests. Here, we present a novel aptamer-based electrochemical biosensor (aptasensor) for malaria detection by impedance spectroscopy, through the specific recognition between a highly discriminatory DNA aptamer and its target Plasmodium falciparum lactate dehydrogenase (PfLDH). Interestingly, due to the isoelectric point (pI) of PfLDH, the aptasensor response showed an adjustable detection range based on the different protein net-charge at variable pH environments. The specific aptamer recognition allows sensitive protein detection with an expanded detection range and a low detection limit, as well as a high specificity for PfLDH compared to analogous proteins. The specific feasibility of the aptasensor is further demonstrated by detection of the target PfLDH in human serum. Furthermore, the aptasensor can be easily regenerated and thus applied for multiple usages. The robustness, sensitivity, and reusability of the presented aptasensor make it a promising candidate for point-of-care diagnostic systems.
Y1  - 2018
U6  - https://doi.org/10.1016/j.snb.2017.07.117
SN  - 0925-4005
VL  - 255
IS  - P1
SP  - 235
EP  - 243
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Finger, Felix
A1  - Braun, Carsten
A1  - Bil, Cees
T1  - Case studies in initial sizing for hybrid-electric general aviation aircraft
T2  - 2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio
Y1  - 2018
U6  - https://doi.org/10.2514/6.2018-5005
ER  -