TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - http://dx.doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Inagaki, Akiko
A1  - Sleddens-Linkels, Esther
A1  - Wassenaar, Evelyne
A1  - Ooms, Marja
A1  - Cappellen, Wiggert A. van
A1  - Hoeijmakers, Jan H. J.
A1  - Seibler, Jost
A1  - Vogt, Thomas F.
A1  - Shin, Myung K.
A1  - Grootegoed, J. Anton
A1  - Baarends, Willy M.
T1  - Meiotic functions of RAD18
JF  - Journal of Cell Science
Y1  - 2011
U6  - http://dx.doi.org/10.1242/jcs.081968
SN  - 1477-9137
VL  - 124
IS  - 16
SP  - 2837
EP  - 2850
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Immel, Timo A.
A1  - Groth, Ulrich
A1  - Huhn, Thomas
A1  - Öhlschläger, Peter
T1  - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice
JF  - PLoS ONE
N2  - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
Y1  - 2011
U6  - http://dx.doi.org/10.1371/journal.pone.0017869
VL  - 6
IS  - 3
PB  - Plos
CY  - San Francisco, California, US
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Jolly, Christina
A1  - Wagner, Patrick
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 1161
EP  - 1164
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heiden, W.
A1  - Turek, M.
A1  - Schöning, Michael Josef
T1  - TasteIT : Analyzing chemical sensor data using fuzzy logic
Y1  - 2011
SN  - 978-1-4244-9910-6
N1  - 2011 IEEE Workshop on Merging Fields of Computational Intelligence and Sensor Technology ; 11.-15. April 2011 Paris, France
SP  - 1
EP  - 6
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Heiden, W.
A1  - Turek, M.
A1  - Schöning, Michael Josef
T1  - Analysis of chemical sensor data
JF  - Proceedings of the 4th Russian-German Workshop "Innovation Information Technologies: Theory and practice" : Ufa, Russia, April 8-13, 2011 / eds. Yupsova, Nafisa ...
Y1  - 2011
SN  - 978-5-4221-0159-7
SP  - 76
EP  - 81
PB  - State Aviation Technical Univ.
CY  - Ufa
ER  - 
TY  - JOUR
A1  - Hasegawa, Maki
A1  - Kapelyukh, Yury
A1  - Tahara, Harunobu
A1  - Seibler, Jost
A1  - Rode, Anja
A1  - Krueger, Sylvia
A1  - Lee, Dongtao N.
A1  - Wolf, C. Roland
A1  - Scheer, Nico
T1  - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
JF  - Molecular Pharmacology
Y1  - 2011
U6  - http://dx.doi.org/10.1124/mol.111.071845
SN  - 1521-0111
VL  - 80
IS  - 33
SP  - 518
EP  - 528
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Hartung, Frank
A1  - Kesici, Sinan
A1  - Catrein, Daniel
T1  - DRM protected Dynamic Adaptive HTTP Streaming
JF  - Proceedings of the 2011 ACM Multimedia Systems Conference [Elektronische Ressource] : February 23 - 25, 2011, San Jose, CA, USA / sponsored by: ACM SIGMM
Y1  - 2011
SN  - 9781450305181
N1  - ACM Multimedia Systems Conference ; (2 : ; 2011.02.23-25 : ; San Jose, Calif.)
SP  - 277
EP  - 282
PB  - ACM
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Hanssen, H.
A1  - Nickel, T.
A1  - Drexel, V.
A1  - Hertel, G.
A1  - Emslander, I.
A1  - Sisic, Z.
A1  - Lorang, D.
A1  - Schuster, T.
A1  - Kotliar, Konstantin
A1  - Pressler, A.
A1  - Schmidt-Trucksäss, A.
A1  - Weis, M.
A1  - Halle, M.
T1  - Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity
JF  - Atherosclerosis
Y1  - 2011
SN  - 0021-9150
VL  - 216
IS  - 2
SP  - 433
EP  - 439
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hamm, Laurits
A1  - Hartung, Frank
T1  - High Quality Visual Communication based on IMS
JF  - Mobilkommunikation : Technologien und Anwendungen ; Vorträge der 16. ITG-Fachtagung vom 18. bis 19. Mai 2011 in Osnabrück / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Tagungsleitung: Ralf Tönjes. Programmkomitee/Hrsg.: Peter Roer
Y1  - 2011
SN  - 978-3-8007-3352-1
N1  - ITG-Fachbericht ; 230 ; Fachtagung Mobilkommunikation <16, 2011, Osnabrück>
SP  - 80
EP  - 85
PB  - VDE-Verl.
CY  - Berlin
ER  -