TY  - JOUR
A1  - Amin, Rashid
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Lazarovici, Philip
A1  - Lelkes, Peter I.
T1  - Permeability of an In Vitro Model of Blood Brain Barrier (BBB)
JF  - 13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]
Y1  - 2009
SN  - 978-3-540-92841-6
N1  - IFMBE Proceedings ; 23, Track 1 ; ICBME 2008 3–6 December 2008 Singapore
SP  - 81
EP  - 84
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Leise, Philipp
A1  - Pfetsch, Marc E.
A1  - Schmitt, Andreas
T1  - Algorithmic design and resilience assessment of energy efficient high-rise water supply systems
JF  - Applied Mechanics and Materials
N2  - High-rise water supply systems provide water flow and suitable pressure in all levels of tall buildings. To design such state-of-the-art systems, the consideration of energy efficiency and the anticipation of component failures are mandatory. In this paper, we use Mixed-Integer Nonlinear Programming to compute an optimal placement of pipes and pumps, as well as an optimal control strategy.Moreover, we consider the resilience of the system to pump failures. A resilient system is able to fulfill a predefined minimum functionality even though components fail or are restricted in their normal usage. We present models to measure and optimize the resilience. To demonstrate our approach, we design and analyze an optimal resilient decentralized water supply system inspired by a real-life hotel building.
KW  - MINLP
KW  - Buffering Capacity
KW  - Uncertainty
KW  - Water Supply Networks
KW  - Booster Stations
Y1  - 2018
U6  - https://doi.org/10.4028/www.scientific.net/AMM.885.211
SN  - 1662-7482
VL  - 885
SP  - 211
EP  - 223
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Joggerst, Laura
A1  - Leise, Philipp
A1  - Pfetsch, Marc E.
A1  - Schmitt, Andreas
A1  - Wendt, Janine
T1  - On obligations in the development process of resilient systems with algorithmic design methods
JF  - Applied Mechanics and Materials
N2  - Advanced computational methods are needed both for the design of large systems and to compute high accuracy solutions. Such methods are efficient in computation, but the validation of results is very complex, and highly skilled auditors are needed to verify them. We investigate legal questions concerning obligations in the development phase, especially for technical systems developed using advanced methods. In particular, we consider methods of resilient and robust optimization. With these techniques, high performance solutions can be found, despite a high variety of input parameters. However, given the novelty of these methods, it is uncertain whether legal obligations are being met. The aim of this paper is to discuss if and how the choice of a specific computational method affects the developer’s product liability. The review of legal obligations in this paper is based on German law and focuses on the requirements that must be met during the design and development process.
KW  - legal obligations
KW  - product liability
KW  - design of technical systems
KW  - optimization
KW  - resilience
Y1  - 2018
SN  - 1662-7482
U6  - https://doi.org/10.4028/www.scientific.net/AMM.885.240
VL  - 885
IS  - 885
SP  - 240
EP  - 252
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Pöttgen, Philipp
A1  - Lorenz, Ulf
A1  - Pelz, Peter F.
ED  - Pelz, Peter F.
ED  - Groche, Peter
T1  - Multicriterial optimization of technical systems considering multiple load and availability scenarios
JF  - Applied Mechanics and Materials
N2  - Cheap does not imply cost-effective -- this is rule number one of zeitgeisty system design. The initial investment accounts only for a small portion of the lifecycle costs of a technical system. In fluid systems, about ninety percent of the total costs are caused by other factors like power consumption and maintenance. With modern optimization methods, it is already possible to plan an optimal technical system considering multiple objectives. In this paper, we focus on an often neglected contribution to the lifecycle costs: downtime costs due to spontaneous failures. Consequently, availability becomes an issue.
KW  - sustainability
KW  - availability
KW  - energy efficiency
KW  - mixed-integer linear programming
KW  - system synthesis
Y1  - 2015
SN  - 1660-9336
U6  - https://doi.org/10.4028/www.scientific.net/AMM.807.247
VL  - 807
SP  - 247
EP  - 256
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Lorenz, Ulf
A1  - Pelz, Peter F.
A1  - Pöttgen, Philipp
ED  - Lübbecke, Marco
ED  - Koster, Arie
ED  - Letmathe, Peter
ED  - Madlener, Reihard
ED  - Peis, Britta
ED  - Walther, Grit
T1  - Experimental validation of an enhanced system synthesis approach
JF  - Operations Research Proceedings 2014
N2  - Planning the layout and operation of a technical system is a common task
for an engineer. Typically, the workflow is divided into consecutive stages: First,
the engineer designs the layout of the system, with the help of his experience or of
heuristic methods. Secondly, he finds a control strategy which is often optimized
by simulation. This usually results in a good operating of an unquestioned sys-
tem topology. In contrast, we apply Operations Research (OR) methods to find a
cost-optimal solution for both stages simultaneously via mixed integer program-
ming (MILP). Technical Operations Research (TOR) allows one to find a provable
global optimal solution within the model formulation. However, the modeling error
due to the abstraction of physical reality remains unknown. We address this ubiq-
uitous problem of OR methods by comparing our computational results with mea-
surements in a test rig. For a practical test case we compute a topology and control
strategy via MILP and verify that the objectives are met up to a deviation of 8.7%.
Y1  - 2014
SN  - 978-3-319-28695-2
U6  - https://doi.org/10.1007/978-3-319-28697-6_1
PB  - Springer
CY  - Basel
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Brötz, Nicolas
A1  - Dietrich, Ingo
A1  - Gally, Tristan
A1  - Geßner, Felix
A1  - Kloberdanz, Hermann
A1  - Leise, Philipp
A1  - Pelz, Peter Franz
A1  - Schlemmer, Pia
A1  - Schmitt, Andreas
T1  - Resilience in mechanical engineering - a concept for controlling uncertainty during design, production and usage phase of load-carrying structures
JF  - Applied Mechanics and Materials
N2  - Resilience as a concept has found its way into different disciplines to describe the ability of an individual or system to withstand and adapt to changes in its environment. In this paper, we provide an overview of the concept in different communities and extend it to the area of mechanical engineering. Furthermore, we present metrics to measure resilience in technical systems and illustrate them by applying them to load-carrying structures. By giving application examples from the Collaborative Research Centre (CRC) 805, we show how the concept of resilience can be used to control uncertainty during different stages of product life.
Y1  - 2018
SN  - 1662-7482
U6  - https://doi.org/10.4028/www.scientific.net/AMM.885.187
VL  - 885
SP  - 187
EP  - 198
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Almajhdi, Fahad N.
A1  - Senger, Tilo
A1  - Amer, Haitham M.
A1  - Gissmann, Lutz
A1  - Öhlschläger, Peter
T1  - Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling)
JF  - PLOS one
N2  - Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.
Y1  - 2014
U6  - https://doi.org/10.1371/journal.pone.0113461
SN  - 1932-6203
VL  - 11
IS  - 9
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Allefeld, Carsten
A1  - Bialonski, Stephan
T1  - Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains
JF  - Physical Review E
Y1  - 2007
U6  - https://doi.org/10.1103/PhysRevE.76.066207
SN  - 2470-0053
VL  - 76
IS  - 6
SP  - 066207
ER  - 
TY  - JOUR
A1  - Aliazizi, Fereshteh
A1  - Özsoylu, Dua
A1  - Bakhshi Sichani, Soroush
A1  - Khorshid, Mehran
A1  - Glorieux, Christ
A1  - Robbens, Johan
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Development and Calibration of a Microfluidic, Chip-Based Sensor System for Monitoring the Physical Properties of Water Samples in Aquacultures
JF  - Micromachines
N2  - In this work, we present a compact, bifunctional chip-based sensor setup that measures the temperature and electrical conductivity of water samples, including specimens from rivers and channels, aquaculture, and the Atlantic Ocean. For conductivity measurements, we utilize the impedance amplitude recorded via interdigitated electrode structures at a single triggering frequency. The results are well in line with data obtained using a calibrated reference instrument. The new setup holds for conductivity values spanning almost two orders of magnitude (river versus ocean water) without the need for equivalent circuit modelling. Temperature measurements were performed in four-point geometry with an on-chip platinum RTD (resistance temperature detector) in the temperature range between 2 °C and 40 °C, showing no hysteresis effects between warming and cooling cycles. Although the meander was not shielded against the liquid, the temperature calibration provided equivalent results to low conductive Milli-Q and highly conductive ocean water. The sensor is therefore suitable for inline and online monitoring purposes in recirculating aquaculture systems.
KW  - chip-based sensor setup
KW  - aquaculture
KW  - microfluidics
KW  - impedance spectroscopy
KW  - thermometry
KW  - electrical conductivity of liquids
Y1  - 2024
U6  - https://doi.org/10.3390/mi15060755
SN  - 2072-666X
N1  - This article belongs to the Special Issue "Multisensor Arrays"
N1  - Corresponding author: Michael J. Schöning
VL  - 15
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Alhwarin, Faraj
A1  - Ferrein, Alexander
A1  - Scholl, Ingrid
T1  - IR stereo kinect: improving depth images by combining structured light with IR stereo
Y1  - 2014
SP  - 1
EP  - 9
ER  -