TY  - JOUR
A1  - Wagner, Torsten
A1  - Werner, Frederik
A1  - Miyamoto, K.
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - A high-density multi-point LAPS set-up using a VCSEL array and FPGA control
JF  - Procedia Chemistry. 1 (2009), H. 1
Y1  - 2009
SN  - 1876-6196
N1  - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23
SP  - 1483
EP  - 1486
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Vornholt, Wolfgang
A1  - Werner, Frederik
A1  - Yoshinobu, Tatsuo
A1  - Miyamoto, Ko-Ichiro
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening
JF  - Physics in medicine
N2  - The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.phmed.2016.03.001
SN  - 2352-4510
VL  - 2016
IS  - 1
SP  - 2
EP  - 7
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Shigiahara, N.
A1  - Miyamoto, K.
A1  - Suzurikawa, J.
A1  - Finger, F.
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - Light-addressable Potentiometric Sensors and Light–addressable Electrodes as a Combined Sensor-and-manipulator Microsystem with High Flexibility
JF  - Procedia Engineering
N2  - This work describes the novel combination of the light-addressable electrode (LAE) and the light-addressable potentiometric sensor (LAPS) into a microsystem set-up. Both the LAE as well as the LAPS shares the principle of addressing the active spot by means of a light beam. This enables both systems to manipulate resp. to detect an analyte with a high spatial resolution. Hence, combining both principles into a single set-up enables the active stimulation e.g., by means of electrolysis and a simultaneous observation e.g., the response of an entrapped biological cell by detection of extracellular pH changes. The work will describe the principles of both technologies and the necessary steps to integrate them into a single set-up. Furthermore, examples of application and operation of such systems will be presented.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.proeng.2012.09.290
SN  - 1877-7058
N1  - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012"
IS  - 47
SP  - 890
EP  - 893
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Otto, R.
A1  - Yoshinobu, T.
T1  - A handheld 16 channel pen-type LAPS as a platform for (bio-)electrochemical sensing
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 996
EP  - 997
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Light-addressable potentiometric sensors (LAPS): recent trends and applications
JF  - Electrochemical sensor analysis / edited by S. Alegret ...
Y1  - 2007
SN  - 978-0-444-53053-0
N1  - Wilson & Wilson's comprehensive analytical chemistry ; 49
SP  - 87
EP  - 128
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Rao, C.
A1  - Otto, R.
A1  - Yoshinobu, T.
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Chipkarten-basierter Multikanal lichtadressierbarer potentiometrischer Sensor für analytische Anwendungen in flüssigen Medien
JF  - Neue Herausforderungen und Anwendungen in der Sensortechnik : 7. Dresdner Sensor-Symposium ; 12. - 14. Dezember 2005, Dresden / [Forschungsgesellschaft für Messtechnik, Sensorik und Medizintechnik e.V.]. Gerald Gerlach ... (Hg.)
Y1  - 2005
SN  - 3-938863-29-3
N1  - Dresdner Beiträge zur Sensorik ; 24
SP  - 11
EP  - 14
PB  - TUDpress
CY  - Dresden
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Rao, C.
A1  - Kloock, Joachim P.
A1  - Yoshinobu, T.
A1  - Otto, R.
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - “LAPS Card”—A novel chip card-based light-addressable potentiometric sensor (LAPS)
JF  - Sensors and Actuators B: Chemical. 118 (2006), H. 1-2
Y1  - 2006
SN  - 0925-4005
N1  - Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers
SP  - 33
EP  - 40
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Molina, Roberto
A1  - Yoshinobu, Tatsuo
A1  - Kloock, Joachim P.
A1  - Biselli, Manfred
A1  - Canzoneri, Michele
A1  - Schnitzler, Thomas
A1  - Schöning, Michael Josef
T1  - Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications
JF  - Electrochimica Acta. 53 (2007), H. 2
Y1  - 2007
SN  - 0013-4686
SP  - 305
EP  - 311
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Molina, R.
A1  - Biselli, Manfred
A1  - Canzoneri, Michele
A1  - Schnitzler, Thomas
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells
JF  - Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)
Y1  - 2007
SN  - 1-4244-0841-5
N1  - Eurosensors 21, 2007, Lyon ; International Conference on Solid-State Sensors, Actuators and Microsystems 14, 2007, Lyon
SP  - 1107
EP  - 1110
PB  - IEEE
CY  - Piscataway
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Shigihara, Noriko
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Microfluidic systems with free definable sensor spots by an integrated light-addressable potentiometric sensor
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 791
EP  - 794
PB  - Elsevier
CY  - Amsterdam
ER  -