TY  - JOUR
A1  - Scheer, Nico
A1  - Henderson, Colin James
A1  - Kapelyukh, Yury
A1  - Rode, Anja
A1  - Mclaren, Aileen W.
A1  - MacLeod, Alastair Kenneth
A1  - Lin, De
A1  - Wright, Jayne
A1  - Stanley, Lesley
A1  - Wolf, C. Roland
T1  - An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials
JF  - Drug Metabolism and Disposition
Y1  - 2019
U6  - https://doi.org/10.1124/dmd.119.086397
IS  - Early view
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Groth, Anne
A1  - Hans, Stefan
A1  - Campos-Ortega, José A.
T1  - An instructive function for Notch in promoting gliogenesis in the zebrafish retina
JF  - Development
Y1  - 2001
SN  - 0950-1991
VL  - 128
IS  - 7
SP  - 1099
EP  - 1107
ER  - 
TY  - CHAP
A1  - Scheer, Nico
A1  - Chu, Xiaoyan
A1  - Salphati, Laurent
A1  - Zamek-Gliszczynski, Maciej J.
ED  - Nicholls, Glynis
T1  - Knockout and humanized animal models to study membrane transporters in drug development
T2  - Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development
Y1  - 2016
SN  - 978-1-78262-379-3
U6  - https://doi.org/10.1039/9781782623793-00298
SP  - 298
EP  - 332
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Campos-Ortega, José A.
T1  - Use of the Gal4-UAS technique for targeted gene expression in the zebrafish
JF  - Mechanism of Development
Y1  - 1999
U6  - https://doi.org/10.1016/S0925-4773(98)00209-3
SN  - 0925-4773
VL  - 80
IS  - 2
SP  - 153
EP  - 158
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Balimane, Praveen
A1  - Hayward, Michael D.
A1  - Buechel, Sandra
A1  - Kauselmann, Gunther
A1  - Wolf, C. Roland
T1  - Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
JF  - Drug Metabolism and Disposition
N2  - The multidrug resistance protein (MRP) 2 is predominantly expressed in liver, intestine, and kidney, where it plays an important role in the excretion of a range of drugs and their metabolites or endogenous compounds into bile, feces, and urine. Mrp knockout [Mrp2(−/−)] mice have been used recently to study the role of MRP2 in drug disposition. Here, we describe the first generation and initial characterization of a mouse line humanized for MRP2 (huMRP2), which is nulled for the mouse Mrp2 gene and expresses the human transporter in the organs and cell types where MRP2 is normally expressed. Analysis of the mRNA expression for selected cytochrome P450 and transporter genes revealed no major changes in huMRP2 mice compared with wild-type controls. We show that human MRP2 is able to compensate functionally for the loss of the mouse transporter as demonstrated by comparable bilirubin levels in the humanized mice and wild-type controls, in contrast to the hyperbilirubinemia phenotype that is observed in MRP2(−/−) mice. The huMRP2 mouse provides a model to study the role of the human transporter in drug disposition and in assessing the in vivo consequences of inhibiting this transporter by compounds interacting with human MRP2.
Y1  - 2012
U6  - https://doi.org/10.1124/dmd.112.047605
SN  - 1521-0111
VL  - 40
IS  - 11
SP  - 2212
EP  - 2218
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Scheele, Sandra
A1  - Oertel, Dan
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Hellmuth, Hendrik
A1  - Maurer, Karl-Heinz
A1  - Bott, Michael
A1  - Freudl, Roland
T1  - Secretory production of an FAD cofactor-containing cytosolic enzyme (sorbitol–xylitol oxidase from Streptomyces coelicolor) using the twin-arginine translocation (Tat) pathway of Corynebacterium glutamicum
JF  - Microbial biotechnology
Y1  - 2013
SN  - 1751-7915
SP  - 202
EP  - 206
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Schartner, Karl-Heinz
A1  - Loeb, H. W.
A1  - Dachwald, Bernd
A1  - Ohndorf, Andreas
T1  - Perspectives of electric propulsion for outer planetary and deep space missions
T2  - European Planetary Science Congress 2009
N2  - Solar-electric propulsion (SEP) is superior with
respect to payload capacity, flight time and
flexible launch window to the conventional
interplanetary transfer method using chemical
propulsion combined with gravity assists. This fact
results from the large exhaust velocities of electric
low–thrust propulsion and is favourable also for
missions to the giant planets, Kuiper-belt objects
and even for a heliopause probe (IHP) as shown in
three studies by the authors funded by DLR. They
dealt with a lander for Europa and a sample return
mission from a mainbelt asteroid [1], with the
TANDEM mission [2]; the third recent one
investigates electric propulsion for the transfer to
the edge of the solar system.
All studies are based on triple-junction solar arrays,
on rf-ion thrusters of the qualified RIT-22 type and
they use the intelligent trajectory optimization
program InTrance [3].
Y1  - 2009
N1  - European Planetary Science Congress 2009, 13-18 September, Potsdam, Germany
SP  - 416
EP  - 416
ER  - 
TY  - JOUR
A1  - Schael, S.
A1  - Atanasyan, A.
A1  - Berdugo, J.
A1  - Bretz, T.
A1  - Czupalla, Markus
A1  - Dachwald, Bernd
A1  - Doetinchem, P. von
A1  - Duranti, M.
A1  - Gast, H.
A1  - Karpinski, W.
A1  - Kirn, T.
A1  - Lübelsmeyer, K.
A1  - Maña, C.
A1  - Marrocchesi, P.S.
A1  - Mertsch, P.
A1  - Moskalenko, I.V.
A1  - Schervan, T.
A1  - Schluse, M.
A1  - Schröder, K.-U.
A1  - Schultz von Dratzig, A.
A1  - Senatore, C.
A1  - Spies, L.
A1  - Wakely, S.P.
A1  - Wlochal, M.
A1  - Uglietti, D.
A1  - Zimmermann, J.
T1  - AMS-100: The next generation magnetic spectrometer in space – An international science platform for physics and astrophysics at Lagrange point 2
JF  - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Y1  - 2019
U6  - https://doi.org/10.1016/j.nima.2019.162561
SN  - 0168-9002
VL  - 944
IS  - 162561
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schaefer, Thomas
A1  - Höfken, Hans-Wilhelm
A1  - Schuba, Marko
T1  - Windows Phone 7 from a Digital Forensics’ Perspective
Y1  - 2011
N1  - ICDF2C <3, 2011, Dublin>
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Sawada, Kazuaki
A1  - Nakazawa, Hirokazu
A1  - Takenaga, Shoko
A1  - Hizawa, Takeshi
A1  - Futagawa, Masato
A1  - Dasai, Fumihiro
A1  - Sakurai, Takashi
A1  - Okumura, Koichi
A1  - Hattori, Toshiaki
A1  - Ishida, Makoto
T1  - Multimodal bioimage sensor
JF  - IEICE transactions on fundamentals of electronics, communidations and computer sciences
N2  - To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials.
Y1  - 2014
U6  - https://doi.org/10.1587/transfun.E97.A.726
SN  - 0916-8508 (Print) ; 1745-1337 (Online)
VL  - E97-A (2014)
IS  - 3
SP  - 726
EP  - 733
PB  - IEICE
CY  - Tokyo
ER  -