TY  - JOUR
A1  - Murib, Mohammed S.
A1  - Tran, Anh Quang
A1  - Ceuninck, Ward de
A1  - Schöning, Michael Josef
A1  - Nesladek, Milos
A1  - Serpengüzel, Ali
A1  - Wagner, Patrick
T1  - Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres
JF  - Physica Status Solidi A
N2  - Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400 nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 µm radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection.
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100795
SN  - 1862-6319
N1  - Special Issue: "Fundamentals and Applications of Diamond"
VL  - 209
IS  - 9
SP  - 1804
EP  - 1810
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Martens, D.
A1  - Liu, X.
A1  - Bienstman, P.
A1  - Fahlman, M.
A1  - Schöning, Michael Josef
A1  - Michiels, L.
A1  - Haenen, K.
A1  - Serpengüzel, A.
A1  - Wagner, Patrick
T1  - Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands
JF  - Sensors and actuators A: Physical
N2  - In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor.
Y1  - 2015
U6  - https://doi.org/10.1016/j.sna.2014.11.024
SN  - 1873-3069 (E-Journal); 0924-4247 (Print)
VL  - 222
SP  - 212
EP  - 219
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Eurlings, Y.
A1  - Grinsven, B. van
A1  - Boyen, H.-G.
A1  - Conings, B.
A1  - Michiels, L.
A1  - Ameloot, Marcel
A1  - Carleer, R.
A1  - Warmer, J.
A1  - Kaul, P.
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Ceuninck, W. de
A1  - Wagner, P.
T1  - Heat-transfer based characterization of DNA on synthetic sapphire chips
JF  - Sensors and Actuators B: Chemical
N2  - In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material.
Y1  - 2016
U6  - https://doi.org/10.1016/j.snb.2016.02.027
SN  - 0925-4005
VL  - 230
IS  - 230
SP  - 260
EP  - 271
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Grinsven, B. van
A1  - Grieten, L.
A1  - Janssens, S. D.
A1  - Vermeeren, V.
A1  - Eersels, K.
A1  - Broeders, J.
A1  - Ameloot, Marcel
A1  - Michiels, L.
A1  - Ceuninck, W. De
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates
JF  - Physica Status Solidi (A). Vol. 210 (2013), iss. 5
Y1  - 2013
SN  - 0031-8965
SP  - 911
EP  - 917
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Mulsow, Niklas A.
A1  - Hülsen, Benjamin
A1  - Gützlaff, Joel
A1  - Spies, Leon
A1  - Bresser, Andreas
A1  - Dabrowski, Adam
A1  - Czupalla, Markus
A1  - Kirchner, Frank
T1  - Concept and design of an autonomous micro rover for long term lunar exploration
T2  - Proceedings of the 74th International Astronautical Congress
N2  - Research on robotic lunar exploration has seen a broad revival, especially since the Google Lunar X-Prize increasingly brought private endeavors into play. This development is supported by national agencies with the aim of enabling long-term lunar infrastructure for in-situ operations and the establishment of a moon village. One challenge for effective exploration missions is developing a compact and lightweight robotic rover to reduce launch costs and open the possibility for secondary payload options. Existing micro rovers for exploration missions are clearly limited by their design for one day of sunlight and their low level of autonomy. For expanding the potential mission applications and range of use, an extension of lifetime could be reached by surviving the lunar night and providing a higher level of autonomy. To address this objective, the paper presents a system design concept for a lightweight micro rover with long-term mission duration capabilities, derived from a multi-day lunar mission scenario at equatorial regions. Technical solution approaches are described, analyzed, and evaluated, with emphasis put on the harmonization of hardware selection due to a strictly limited budget in dimensions and power.
Y1  - 2023
N1  - 74. International Astronautical Congress (IAC-2023), October 2-6 2023, Baku, Azerbaijan
PB  - dfki
CY  - Saarbrücken
ER  - 
TY  - JOUR
A1  - Mulhern, Colm
A1  - Bialonski, Stephan
A1  - Kantz, Holger
T1  - Extreme events due to localization of energy
JF  - Physical Review E
Y1  - 2015
U6  - https://doi.org/10.1103/PhysRevE.91.012918
SN  - 2470-0053
VL  - 91
IS  - 1
SP  - 012918
ER  - 
TY  - JOUR
A1  - Mukherjee, Krishnendu
A1  - Ramazani, Ali
A1  - Yang, Li
A1  - Prahl, Ulrich
A1  - Bleck, Wolfgang
A1  - Reisgen, Uwe
A1  - Schleser, Markus
A1  - Abdurakhmanov, Aydemir
T1  - Characterization of gas metal arc welded hot rolled DP600 steel
JF  - Steel research international
Y1  - 2011
SN  - 1869-344X (E-Book); 1611-3683 (Print)
VL  - Vol. 82
IS  - Iss. 12
SP  - 1408
EP  - 1416
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Mukherjee, Krishnendu
A1  - Prahl, Ulrich
A1  - Bleck, Wolfgang
A1  - Reisgen, Uwe
A1  - Schleser, Markus
A1  - Abdurakhmanov, Aydemir
T1  - Characterization and modelling techniques for gas metal arc welding of DP 600 sheet steels
JF  - Materialwissenschaft und Werkstofftechnik
N2  - The objectives of the present work are to characterize the Gas Metal Arc Welding process of DP 600 sheet steel and to summarize the modelling techniques. The time-temperature evolution during the welding cycle was measured experimentally and modelled with the softwaretool SimWeld. To model the phase transformations during the welding cycle dilatometer tests were done to quantify the parameters for phase field modelling by MICRESS®. The important input parameters are interface mobility, nucleation density, etc. A contribution was made to include austenite to bainite transformation in MICRESS®. This is useful to predict the microstructure in the fast cooling segments. The phase transformation model is capable to predict the microstructure along the heating and cooling cycles of welding. Tensile tests have shown the evidence of failure at the heat affected zone, which has the ferrite-tempered martensite microstructure.
Y1  - 2010
U6  - https://doi.org/10.1002/mawe.201000692
SN  - 1521-4052
VL  - 41
IS  - 11
SP  - 972
EP  - 983
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Muffler, Kai
A1  - Tippkötter, Nils
A1  - Ulber, Roland
ED  - Timmis, Kenneth N.
T1  - Chemical feedstocks and fine chemicals from other substrates
T2  - Handbook of hydrocarbon and lipid microbiology. Volume 4:  Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference)
Y1  - 2010
SN  - 978-3-540-77588-1
U6  - https://doi.org/10.1007%2F978-3-540-77587-4_214
SP  - 2891
EP  - 2902
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - CHAP
A1  - Muffler, Kai
A1  - Poth, Sabastian
A1  - Sieker, Tim
A1  - Tippkötter, Nils
A1  - Ulber, Roland
A1  - Sell, Dieter
ED  - Moo-Young, Murray
T1  - Bio-feedstocks
T2  - Comprehensive biotechnology : principles and practices in industry, agcriculture, medicine and the environment. Volume 2: Engineering fundamentals of biotechnology
Y1  - 2011
SN  - 978-0-444-53352-4
U6  - https://doi.org/10.1016/B978-0-08-088504-9.00088-X
SP  - 93
EP  - 101
PB  - Elsevier
CY  - Amsterdam
ET  - 2. edition
ER  -