TY - JOUR A1 - Kallweit, Stephan A1 - Korculanin, O. A1 - Fröhlig, F. A1 - Gabi, M. A1 - Mattern, P. T1 - Photogrammetrische Rekonstruktion von Partikelpositionen mittels Rückprojektion für 3D-PIV JF - Lasermethoden in der Strömungsmesstechnik : 19. Fachtagung, 6. - 8. September 2011, Ilmenau ; [Tagungsband enthält ... Beiträge, die anlässlich der 19. Fachtagaung "Lasermethoden in der Strömungsmesstechnik" ... vorgetragen und diskutiert wurden] / veranst. von der Deutschen Gesellschaft für Laser-Anemometrie GALA e.V. Hrsg. A. Thess... Y1 - 2011 SN - 978-3-9805613-7-2 N1 - Fachtagung Lasermethoden in der Strömungsmesstechnik <19, 2011, Ilmenau> ; Deutsche Gesellschaft für Laser-Anemometrie SP - 28/1 EP - 28/6 PB - Dt. Ges. für Laser-AnemometrieGALA e. V. CY - Karlsruhe ER - TY - JOUR A1 - Jordan, Sabine D. A1 - Krüger, Markus A1 - Willmes, Diana M. A1 - Redemann, Nora A1 - Wunderlich, F. Thomas A1 - Brönneke, Hella S. A1 - Merkwirth, Carsten A1 - Kashkar, Hamid A1 - Olkkonen, Vesa M. A1 - Böttger, Thomas A1 - Braun, Thomas A1 - Seibler, Jost A1 - Brüning, Jens C. T1 - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism JF - Nature Cell Biology N2 - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes. Y1 - 2011 U6 - https://doi.org/10.1038/ncb2211 SN - 1465-7392 VL - 13 IS - 4 SP - 434 EP - 446 PB - Nature CY - New York ER - TY - JOUR A1 - Inagaki, Akiko A1 - Sleddens-Linkels, Esther A1 - Wassenaar, Evelyne A1 - Ooms, Marja A1 - Cappellen, Wiggert A. van A1 - Hoeijmakers, Jan H. J. A1 - Seibler, Jost A1 - Vogt, Thomas F. A1 - Shin, Myung K. A1 - Grootegoed, J. Anton A1 - Baarends, Willy M. T1 - Meiotic functions of RAD18 JF - Journal of Cell Science Y1 - 2011 U6 - https://doi.org/10.1242/jcs.081968 SN - 1477-9137 VL - 124 IS - 16 SP - 2837 EP - 2850 PB - Company of Biologists Limited CY - Cambridge ER - TY - JOUR A1 - Immel, Timo A. A1 - Groth, Ulrich A1 - Huhn, Thomas A1 - Öhlschläger, Peter T1 - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice JF - PLoS ONE N2 - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future. Y1 - 2011 U6 - https://doi.org/10.1371/journal.pone.0017869 VL - 6 IS - 3 PB - Plos CY - San Francisco, California, US ER - TY - JOUR A1 - Hüning, Felix T1 - PowerMOSFETs in ANL2-Technologie : Ansteuerungen bis in den kW-Bereich mit wenig Verlustleistung und Platzbedarf JF - Elektronik-Industrie Y1 - 2011 SN - 0174-5522 VL - 42 IS - 10 SP - 36 EP - 39 PB - Hüthig CY - Heidelberg ER - TY - CHAP A1 - Höttges, Jörg A1 - Rolfing, Richard A1 - Sieker, Heiko A1 - Siekmann, Marko A1 - Wermter, Paul ED - Pinnekamp, Johannes T1 - GIS-gestützte Erstellung von Niederschlagswasserbeseitigungskonzepten T2 - 12. Kölner Kanal- und Kläranlagen-Kolloquium : 13. und 14. Oktober 2011 im Maternushaus, Köln / ISA, Institut und Lehrstuhl für Siedlungswasserwirtschaft Y1 - 2011 SN - 978-3-938996-08-9 N1 - Aachener Schriften zur Stadtentwässerung ; 15 SP - 8/1 EP - 8/13 PB - Ges. zur Förderung der Siedlungswasserwirtschaft an der RWTH Aachen CY - Aachen ER - TY - CHAP A1 - Höttges, Jörg ED - Pinnekamp, Johannes T1 - GIS-gestützte Niederschlagswasserbeseitigungskonzepte - Aufgaben und Inhalte T2 - 44. Essener Tagung für Wasser- und Abfallwirtschaft : "zukunftsfähige Wasserwirtschaft - kosteneffizient und energiebewusst"; 23. bis 25. März 2011 im Eurogress Aachen Y1 - 2011 SN - 978-3-938996-29-4 N1 - Gewässerschutz, Wasser, Abwasser ; 223 SP - 29/1 EP - 29/14 PB - Ges. zur Förderung der Siedlungswasserwirtschaft an der RWTH Aachen CY - Aachen ER - TY - JOUR A1 - Huck, Christina A1 - Jolly, Christina A1 - Wagner, Patrick A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen JF - Procedia Engineering. 25 (2011) Y1 - 2011 SN - 1877-7058 N1 - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece SP - 1161 EP - 1164 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Huck, Christina A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Bifunktionaler Sensorchip für den Nachweis von Gelöstwasserstoff Y1 - 2011 SN - 978-3942710-53-4 U6 - https://doi.org/10.5162/10dss2011/16.10 SP - 325 EP - 328 ER - TY - CHAP A1 - Huber, Frédéric A1 - Bleck, Wolfgang A1 - Scheik, Sven A1 - Schleser, Markus A1 - Reisgen, Uwe T1 - Investigation of galvanneal coating adherence in adhesive bonded joints using lap shear test T2 - Galvatech 2011 : 8th International Conference on Zinc and Zinc Alloy Coated Steel Sheet, June 21 - 24, 2011, Genova (Italy) ; proceedings Y1 - 2011 SN - 978-88-85298-82-8 SP - Paper No. 43 PB - Associazione Italiana di Metallurgia CY - Mailand ER -