TY  - JOUR
A1  - Damm, Alexander
A1  - Erler, André
A1  - Hillen, Walter
A1  - Meroni, Michele
A1  - Schaepman, Michael E.
A1  - Verhoef, Wout
A1  - Rascher, Uwe
T1  - Modeling the impact of spectral sensor configurations on the FLD retrieval accuracy of sun-induced chlorophyll fluorescence
JF  - Remote Sensing of Environment
Y1  - 2011
SN  - 0034-4257
VL  - 115
IS  - 8
SP  - 1882
EP  - 1892
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dallas, Shannon
A1  - Salphati, Laurent
A1  - Gomez-Zepeda, David
A1  - Wanek, Thomas
A1  - Chen, Liangfu
A1  - Chu, Xiaoyan
A1  - Kunta, Jeevan
A1  - Mezler, Mario
A1  - Menet, Marie-Claude
A1  - Chasseigneaux, Stephanie
A1  - Declèves, Xavier
A1  - Langer, Oliver
A1  - Pierre, Esaie
A1  - DiLoreto, Karen
A1  - Hoft, Carolin
A1  - Laplanche, Loic
A1  - Pang, Jodie
A1  - Pereira, Tony
A1  - Andonian, Clara
A1  - Simic, Damir
A1  - Rode, Anja
A1  - Yabut, Jocelyn
A1  - Zhang, Xiaolin
A1  - Scheer, Nico
T1  - Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model
JF  - Molecular Pharmacology
N2  - Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp−/−) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP.
Y1  - 2016
U6  - https://doi.org/10.1124/mol.115.102079
SN  - 1521-0111
VL  - 89
IS  - 5
SP  - 492
EP  - 504
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - CHAP
A1  - Dalguer, Luis A.
A1  - Churilov, Sergey
A1  - Butenweg, Christoph
A1  - Renault, Philippe
A1  - Hyun, An Jun
T1  - Dynamic analysis of a reinforced concrete electrical nuclear building of SMART 2013 project subjected to earthquake excitation using ABAQUS
T2  - Workshop SMART2013 : Paris, France, November 25th - 27th, 2014
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - THES
A1  - Dahmen-Beumers, Judith
T1  - Eine exemplarische Untersuchung zur Regionalität in der Kunst : der Aachener Bildhauer und Maler Benno Werth (*1929)
KW  - Kunstmarkt
KW  - Geschichte
KW  - Aachen
Y1  - 2005
SN  - 3-8334-3014-1
SN  - 9783833430145
PB  - Books on Demand
CY  - Norderstedt
ER  - 
TY  - JOUR
A1  - Dahmann, Peter
A1  - Mager, M.
T1  - Einfluß der Zusammensetzung der abzuscheidenden Verschmutzung auf die Abscheideleistung von Hydraulikfiltern
JF  - Ölhydraulik und Pneumatik. 38 (1994), H. 4
Y1  - 1994
SN  - 0341-2660
SP  - 212
EP  - 214
ER  - 
TY  - JOUR
A1  - Dahmann, Peter
A1  - Hagemeister, Wilhelm
A1  - Nagel, Günther
A1  - Exner, Peter
T1  - Geregelte Innenzahnradpumpe im Mehrquadrantenbetrieb Geschwindigkeits- und Positionsregelung eines hydraulischen Handlinggerätes
JF  - O+P Ölhydraulik und Pneumatik. 24 (2006), H. 1
Y1  - 2006
SN  - 0341-2660
SP  - 24
EP  - 28
ER  - 
TY  - JOUR
A1  - Dahmann, Peter
A1  - Hagemeister, W.
A1  - Nagel, 
A1  - Exner, 
T1  - Geschwindigkeits- und Positionsregelung eines hydraulischen Handlinggerätes in einem Ziegelwerk durch frequenzgeregelte Innenzahnradpumpe im Mehrquadrantenbetrieb
JF  - Fluid power focused on applications : 3rd International Fluid Power Conference (3rd IFK) ; [conference proceedings, March 5th and 6th 2002, Aachen, Germany]. Fluidtechnik, Band T3
Y1  - 2002
SN  - 3-8265-9900-4
N1  - Konferenz-Einzelbericht
SP  - 83
EP  - 94
PB  - Shaker
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Dahmann, Peter
T1  - Offen für neue Modelle. GL-Hydraulik setzt neues Simulationssystem ein
JF  - Fluid Heft Sonderpublikation Fluid-Technik. 29 (1995)
Y1  - 1995
SN  - 0015-461X
SP  - 8
EP  - 10
ER  - 
TY  - THES
A1  - Dahmann, Peter
T1  - Untersuchungen zur Wirksamkeit von Filtern in hydraulischen Anlagen
Y1  - 1992
N1  - Aachen, Techn. Hochsch., Diss., 1992
ER  - 
TY  - JOUR
A1  - Dahmann, Peter
T1  - Leistungsfähigkeit von Hydraulikfiltern bei unterschiedlichen Betriebsbedingungen
JF  - Ölhydraulik und Pneumatik. 34 (1990), H. 10
Y1  - 1990
SN  - 0341-2660
SP  - 682
EP  - 688
ER  -