TY - CHAP A1 - Finkenberger, Isabel Maria ED - Pufke, Andrea T1 - Räumliche Transformation als Planungsaufgabe T2 - Zurück in die Zukunft. Denkmalpflege und Strukturwandel im Rheinischen Revier Y1 - 2024 N1 - Mitteilungen aus dem LVR-Amt für Denkmalpflege im Rheinland 39 : Zurück in die Zukunft. Denkmalpflege und Strukturwandel im Rheinischen Revier. Dokumentation zum 7. Rheinischen Tag für Denkmalpflege in Morschenich, 2. Juni 2022 SP - 70 EP - 77 PB - LVR-Amt für Denkmalpflege im Rheinland CY - Pulheim ER - TY - JOUR A1 - Fiedler, Thomas M. A1 - Orzada, Stephan A1 - Flöser, Martina A1 - Rietsch, Stefan H. G. A1 - Schmidt, Simon A1 - Stelter, Jonathan K. A1 - Wittrich, Marco A1 - Quick, Harald H. A1 - Bitz, Andreas A1 - Ladd, Mark E. T1 - Performance and safety assessment of an integrated transmit array for body imaging at 7 T under consideration of specificabsorption rate, tissue temperature, and thermal dose JF - NMR in Biomedicine N2 - In this study, the performance of an integrated body-imaging array for 7 T with 32 radiofrequency (RF) channels under consideration of local specific absorption rate (SAR), tissue temperature, and thermal dose limits was evaluated and the imaging performance was compared with a clinical 3 T body coil. Thirty-two transmit elements were placed in three rings between the bore liner and RF shield of the gradient coil. Slice-selective RF pulse optimizations for B1 shimming and spokes were performed for differently oriented slices in the body under consideration of realistic constraints for power and local SAR. To improve the B1+ homogeneity, safety assessments based on temperature and thermal dose were performed to possibly allow for higher input power for the pulse optimization than permissible with SAR limits. The results showed that using two spokes, the 7 T array outperformed the 3 T birdcage in all the considered regions of interest. However, a significantly higher SAR or lower duty cycle at 7 T is necessary in some cases to achieve similar B1+ homogeneity as at 3 T. The homogeneity in up to 50 cm-long coronal slices can particularly benefit from the high RF shim performance provided by the 32 RF channels. The thermal dose approach increases the allowable input power and the corresponding local SAR, in one example up to 100 W/kg, without limiting the exposure time necessary for an MR examination. In conclusion, the integrated antenna array at 7 T enables a clinical workflow for body imaging and comparable imaging performance to a conventional 3 T clinical body coil. KW - body imaging at 7 T MRI KW - thermal dose KW - tissue temperature KW - transmit antenna arrays Y1 - 2022 U6 - https://doi.org/10.1002/nbm.4656 SN - 0952-3480 (Print) SN - 1099-1492 (Online) VL - 35 IS - 5 SP - 1 EP - 17 PB - Wiley ER - TY - GEN A1 - Feldmann, Marco A1 - Francke, Gero A1 - Espe, Clemes A1 - Chen, Qian A1 - Baader, Fabian A1 - Boxberg, Marc S. A1 - Sustrate, Anna-Marie A1 - Kowalski, Julia A1 - Dachwald, Bernd T1 - Performance data of an ice-melting probe from field tests in two different ice environments N2 - This dataset was acquired at field tests of the steerable ice-melting probe "EnEx-IceMole" (Dachwald et al., 2014). A field test in summer 2014 was used to test the melting probe's system, before the probe was shipped to Antarctica, where, in international cooperation with the MIDGE project, the objective of a sampling mission in the southern hemisphere summer 2014/2015 was to return a clean englacial sample from the subglacial brine reservoir supplying the Blood Falls at Taylor Glacier (Badgeley et al., 2017, German et al., 2021). The standardized log-files generated by the IceMole during melting operation include more than 100 operational parameters, housekeeping information, and error states, which are reported to the base station in intervals of 4 s. Occasional packet loss in data transmission resulted in a sparse number of increased sampling intervals, which where compensated for by linear interpolation during post processing. The presented dataset is based on a subset of this data: The penetration distance is calculated based on the ice screw drive encoder signal, providing the rate of rotation, and the screw's thread pitch. The melting speed is calculated from the same data, assuming the rate of rotation to be constant over one sampling interval. The contact force is calculated from the longitudinal screw force, which es measured by strain gauges. The used heating power is calculated from binary states of all heating elements, which can only be either switched on or off. Temperatures are measured at each heating element and averaged for three zones (melting head, side-wall heaters and back-plate heaters). KW - Ocean Worlds KW - Icy Moons KW - Cryobot KW - Analogue Environments KW - Melting Efficiency KW - Melting Performance KW - Melting Probe KW - Ice Melting Y1 - 2022 U6 - https://doi.org/10.5281/zenodo.6094866 N1 - Forschungsdaten zu "Field-test performance of an ice-melting probe in a terrestrial analogue environment" (https://opus.bibliothek.fh-aachen.de/opus4/frontdoor/index/index/docId/10889) ER - TY - JOUR A1 - Falkenberg, Fabian A1 - Rahba, Jade A1 - Fischer, David A1 - Bott, Michael A1 - Bongaerts, Johannes A1 - Siegert, Petra T1 - Biochemical characterization of a novel oxidatively stable, halotolerant, and high-alkaline subtilisin from Alkalihalobacillus okhensis Kh10-101T JF - FEBS Open Bio N2 - Halophilic and halotolerant microorganisms represent a promising source of salt-tolerant enzymes suitable for various biotechnological applications where high salt concentrations would otherwise limit enzymatic activity. Considering the current growing enzyme market and the need for more efficient and new biocatalysts, the present study aimed at the characterization of a high-alkaline subtilisin from Alkalihalobacillus okhensis Kh10-101T. The protease gene was cloned and expressed in Bacillus subtilis DB104. The recombinant protease SPAO with 269 amino acids belongs to the subfamily of high-alkaline subtilisins. The biochemical characteristics of purified SPAO were analyzed in comparison with subtilisin Carlsberg, Savinase, and BPN'. SPAO, a monomer with a molecular mass of 27.1 kDa, was active over a wide range of pH 6.0–12.0 and temperature 20–80 °C, optimally at pH 9.0–9.5 and 55 °C. The protease is highly oxidatively stable to hydrogen peroxide and retained 58% of residual activity when incubated at 10 °C with 5% (v/v) H2O2 for 1 h while stimulated at 1% (v/v) H2O2. Furthermore, SPAO was very stable and active at NaCl concentrations up to 5.0 m. This study demonstrates the potential of SPAO for biotechnological applications in the future. KW - Alkalihalobacillus okhensis KW - detergent protease KW - halotolerant protease KW - high-alkaline subtilisin KW - oxidative stable protease Y1 - 2022 U6 - https://doi.org/10.1002/2211-5463.13457 SN - 2211-5463 N1 - Corresponding author: Petra Siegert VL - 12 IS - 10 SP - 1729 EP - 1746 PB - Wiley CY - Hoboken, NJ ER - TY - JOUR A1 - Falkenberg, Fabian A1 - Bott, Michael A1 - Bongaerts, Johannes A1 - Siegert, Petra T1 - Phylogenetic survey of the subtilase family and a data-mining-based search for new subtilisins from Bacillaceae JF - Frontiers in Microbiology N2 - The subtilase family (S8), a member of the clan SB of serine proteases are ubiquitous in all kingdoms of life and fulfil different physiological functions. Subtilases are divided in several groups and especially subtilisins are of interest as they are used in various industrial sectors. Therefore, we searched for new subtilisin sequences of the family Bacillaceae using a data mining approach. The obtained 1,400 sequences were phylogenetically classified in the context of the subtilase family. This required an updated comprehensive overview of the different groups within this family. To fill this gap, we conducted a phylogenetic survey of the S8 family with characterised holotypes derived from the MEROPS database. The analysis revealed the presence of eight previously uncharacterised groups and 13 subgroups within the S8 family. The sequences that emerged from the data mining with the set filter parameters were mainly assigned to the subtilisin subgroups of true subtilisins, high-alkaline subtilisins, and phylogenetically intermediate subtilisins and represent an excellent source for new subtilisin candidates. Y1 - 2022 U6 - https://doi.org/10.3389/fmicb.2022.1017978 SN - 1664-302X VL - 2022 IS - 13 PB - Frontiers CY - Lausanne ER - TY - CHAP A1 - Fabo, Sabine T1 - Plüschviren – Zur Konstruktion von Nähe in Zeiten der Pandemie T2 - Interaktion – Emotion – Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana Müller, Niklas von Reischach (Hrsg.) Y1 - 2022 SN - 978-3-593-51520-5 (Print) SN - 978-3-593-44960-9 (E-Book) SP - 45 EP - 69 PB - Campus CY - Frankfurt ; New York ER - TY - CHAP A1 - Fabo, Sabine T1 - Pandemische Momente T2 - Interaktion – Emotion – Desinfektion ; Kunst und Museum in Zeiten von Corona / Birgit Richard, Jana Müller, Niklas von Reischach (Hrsg.) Y1 - 2022 SN - 978-3-593-51520-5 (Print) SN - 978-3-593-44960-9 (E-Book) SP - 137 EP - 140 PB - Campus CY - Frankfurt ; New York ER - TY - JOUR A1 - Fabo, Sabine ED - Wirth, Jacob T1 - Das Parasitäre in der Pandemie JF - Parasite Art Y1 - 2022 IS - Issue 2 SP - 8 EP - 11 PB - Parasite Art ER - TY - CHAP A1 - Evans, Benjamin A1 - Braun, Sebastian A1 - Ulmer, Jessica A1 - Wollert, Jörg T1 - AAS implementations - current problems and solutions T2 - 20th International Conference on Mechatronics - Mechatronika (ME) N2 - The fourth industrial revolution presents a multitude of challenges for industries, one of which being the increased flexibility required of manufacturing lines as a result of increased consumer demand for individualised products. One solution to tackle this challenge is the digital twin, more specifically the standardised model of a digital twin also known as the asset administration shell. The standardisation of an industry wide communications tool is a critical step in enabling inter-company operations. This paper discusses the current state of asset administration shells, the frameworks used to host them and their problems that need to be addressed. To tackle these issues, we propose an event-based server capable of drastically reducing response times between assets and asset administration shells and a multi-agent system used for the orchestration and deployment of the shells in the field. KW - Industry 4.0 KW - Multi-agent Systems KW - Digital Twin KW - Asset Administration Shell Y1 - 2022 SN - 978-1-6654-1040-3 U6 - https://doi.org/10.1109/ME54704.2022.9982933 N1 - 20th International Conference on Mechatronics - Mechatronika (ME), 07-09 December 2022, Pilsen, Czech Republic PB - IEEE CY - New York, NY ER - TY - CHAP A1 - Engländer, Jacques A1 - Kaminski, Lars A1 - Schuba, Marko T1 - Informationssicherheitsmanagement T2 - Digitalisierungs- und Informationsmanagement N2 - Daten und Informationen sind die wichtigsten Ressourcen vieler Unternehmen und müssen daher entsprechend geschützt werden. Getrieben durch die erhöhte Vernetzung von Informationstechnologie, die höhere Offenheit infolge datengetriebener Dienstleistungen und eine starke Zunahme an Datenquellen, rücken die Gefahren von Informationsdiebstahl, -manipulation und -verlust in den Fokus von produzierenden Unternehmen. Auf dem Weg zum lern- und wandlungsfähigen Unternehmen kann dies zu einem großen Hindernis werden, da einerseits zu hohe Sicherheitsanforderungen neue Entwicklungen beschränken, andererseits wegen des Mangels an ausreichenden Informationssicherheitskonzepten Unternehmen weniger Innovationen wagen. Deshalb bedarf es individuell angepasster Konzepte für die Bereiche IT-Security, IT-Safety und Datenschutz für vernetzte Produkte, Produktion und Arbeitsplätze. Bei der Entwicklung und Durchsetzung dieser Konzepte steht der Faktor Mensch im Zentrum aller Überlegungen. In diesem Kapitel wird dargestellt, wie der Faktor Mensch bei der Erstellung von Informationssicherheitskonzepten in verschiedenen Phasen zu beachten ist. Beginnend mit der Integration von Informationssystemen und damit verbundenen Sicherheitsmaßnahmen, über die Administration, bis hin zur Anwendung durch den Endnutzer, werden Methoden beschrieben, die den Menschen, verbunden mit seinem Mehrwert wie auch den Risiken, einschließen. Dabei werden sowohl Grundlagen aufgezeigt als auch Konzepte vorgestellt, mit denen Entscheider in der Unternehmens-IT Leitlinien für die Informationssicherheit festlegen können. KW - Informationssicherheitsmanagement KW - Cybersicherheit KW - Cybersecurity KW - Informationssicherheit KW - IT-Sicherheit Y1 - 2022 SN - 978-3-662-63757-9 SN - 978-3-662-63758-6 U6 - https://doi.org/10.1007/978-3-662-63758-6_15 SP - 373 EP - 398 PB - Springer Vieweg CY - Berlin ER -