TY - JOUR A1 - Pieper, Martin A1 - Klein, Peter T1 - Numerical solution of the heat equation with non-linear, time derivative-dependent source term JF - International Journal for Numerical Methods in Engineering N2 - The mathematical modeling of heat conduction with adsorption effects in coated metal structures yields the heat equation with piecewise smooth coefficients and a new kind of source term. This term is special, because it is non-linear and furthermore depends on a time derivative. In our approach we reformulated this as a new problem for the usual heat equation, without source term but with a new non-linear coefficient. We gave an existence and uniqueness proof for the weak solution of the reformulated problem. To obtain a numerical solution, we developed a semi-implicit and a fully implicit finite volume method. We compared these two methods theoretically as well as numerically. Finally, as practical application, we simulated the heat conduction in coated aluminum fibers with adsorption in the zeolite coating. Copyright © 2010 John Wiley & Sons, Ltd. Y1 - 2010 U6 - https://doi.org/10.1002/nme.2937 SN - 0029-5981 VL - 84 IS - 10 SP - 1205 EP - 1221 PB - Wiley CY - Chichester ER - TY - JOUR A1 - Werner, Frederik A1 - Groebel, Simone A1 - Krumbe, Christoph A1 - Wagner, Torsten A1 - Selmer, Thorsten A1 - Yoshinobu, Tatsuo A1 - Baumann, Marcus A1 - Schöning, Michael Josef T1 - Nutrient concentration-sensitive microorganism-based biosensor JF - Physica Status Solidi (a) Y1 - 2012 U6 - https://doi.org/10.1002/pssa.201100801 SN - 1862-6319 VL - 209 IS - 5 SP - 900 EP - 904 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Unden, G. A1 - Becker, S. A1 - Bongaerts, Johannes A1 - Holighaus, G. A1 - Schirawski, J. A1 - Six, S. T1 - O2-sensing and O2-dependent gene regulation in facultatively anaerobic bacteria JF - Archives of microbiology Y1 - 1995 SN - 1432-072X (E-Journal); 0003-9276 (Print); 0302-8933 (Print) VL - Vol. 164 IS - Iss. 2 SP - 81 EP - 90 ER - TY - JOUR A1 - Kornfeld, Jan-Wilhelm A1 - Baitzel, Catherina A1 - Könner, A. Christine A1 - Nicholls, Hayley T. A1 - Vogt, Merly C. A1 - Herrmanns, Karolin A1 - Scheja, Ludger A1 - Haumaitre, Cécile A1 - Wolf, Anna M. A1 - Knippschild, Uwe A1 - Seibler, Jost A1 - Cereghini, Silvia A1 - Heeren, Joerg A1 - Stoffel, Markus A1 - Brüning, Jens C. T1 - Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b JF - Nature Y1 - 2013 SN - 0028-0836 U6 - https://doi.org/10.1038/nature11793 VL - 494 IS - 7435 SP - 111 EP - 115 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Jordan, Sabine D. A1 - Krüger, Markus A1 - Willmes, Diana M. A1 - Redemann, Nora A1 - Wunderlich, F. Thomas A1 - Brönneke, Hella S. A1 - Merkwirth, Carsten A1 - Kashkar, Hamid A1 - Olkkonen, Vesa M. A1 - Böttger, Thomas A1 - Braun, Thomas A1 - Seibler, Jost A1 - Brüning, Jens C. T1 - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism JF - Nature Cell Biology N2 - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes. Y1 - 2011 U6 - https://doi.org/10.1038/ncb2211 SN - 1465-7392 VL - 13 IS - 4 SP - 434 EP - 446 PB - Nature CY - New York ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Lieder, R. M. A1 - Didelez, J. P. A1 - Beuscher, H. T1 - Observation of a New Isomer in ²¹² Po JF - Annual report 1978 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: A. Fässler. - Y1 - 1979 N1 - Spezielle Berichte der Kernforschungsanlage Jülich ; 36 SP - 38 PB - Kernforschungsanlage CY - Jülich ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Lieder, R. M. A1 - Didelez, J. P. A1 - Beuscher, H. T1 - Observation of a New Isomer in ²¹² Po JF - Physical review letters Y1 - 1978 U6 - https://doi.org/10.1103/PhysRevLett.41.742 SN - 0031-9007 VL - 41 IS - 11 SP - 742 EP - 745 PB - American Physical Society CY - Ridge, NY ER - TY - JOUR A1 - Rateike, Franz-Matthias A1 - Weyer, K. G. A1 - Wiedenmann, H. A1 - MacGillivray, W. R. T1 - Observation of absorptive optical bistability in a fabry-perot cavity containing multiple atomic beams / K. G. Weyer ; H. Wiedenmann ; M. Rateike ; W. R. Mac Gillivray ; P. Meystre ; H. Walther JF - Optics communications. 37 (1981), H. 6 Y1 - 1981 SN - 0030-4018 SP - 426 EP - 430 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Neskakis, A. A1 - Lieder, R. M. T1 - Observation of rotation-aligned bands in the odd-odd nuclei ¹⁹⁰,¹⁹²,¹⁹⁴ Au JF - Physics letters / B. 80 (1979), H. 3 Y1 - 1979 SN - 0031-9163 N1 - 2. ISSN: 0370-2693 SP - 194 EP - 197 ER - TY - JOUR A1 - Förster, Arnold A1 - Schmidt, T. A1 - Haug, R. J. T1 - Observation of the local structure of landau bands in a disordered conductor / T. Schmidt ; R. J. Haug ; Vladimir I. Fal'ko ... A. Förster ... JF - Physical review letters. 78 (1997), H. 8 Y1 - 1997 SN - 0031-9007 N1 - ISSN der E-Ausg.: 1079-7114 SP - 1540 EP - 1543 ER -