TY  - JOUR
A1  - Weigand, Christoph
T1  - Defining Precisions for Reliable Measurement and Estimation Procedures
JF  - Economic Quality Control. 24 (2009), H. 1
Y1  - 2009
SN  - 0940-5151
SP  - 5
EP  - 33
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Kapelyukh, Yury
A1  - Henderson, Colin James
A1  - Scheer, Nico
A1  - Rode, Anja
A1  - Wolf, Charles Roland
T1  - Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice
JF  - Drug Metabolism and Disposition
Y1  - 2019
U6  - https://doi.org/10.1124/dmd.119.087718
IS  - Early view
ER  - 
TY  - JOUR
A1  - Breitbach, Gerd
A1  - Schmidt-Plutka, A.
A1  - Schubert, F.
A1  - Nickel, H.
T1  - Deformation behaviour of structures exposed at very high temperatures to cyclic thermal and mechanical loadings
JF  - Structural mechanics in reactor technology : transactions of the 12th International Conference on Structural Mechanics in Reactor Technology, Stuttgart, Germany, 15-20 August 1993 / ed. Karl F. Kussmaul. - Bd. L : Inelastic behaviour of solids and structures
Y1  - 1993
SN  - 0-444-81515-5
N1  - SMiRT <12, 1993, Stuttgart>  ; L08/3
SP  - 203
EP  - 208
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Menzel, S.
A1  - Bäcker, Matthias
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Degradation of thin poly(lactic acid) films: characterization by capacitance-voltage, atomic force microscopy, scanning electron microscopy and contact-angle measurements
JF  - Electrochimica Acta
Y1  - 2013
SN  - 1873-3859 (E-Journal); 0013-4686 (Print)
VL  - Vol. 113
SP  - 779
EP  - 784
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Malan, Leone
A1  - Hamer, Mark
A1  - Känel, Roland von
A1  - Kotliar, Konstantin
A1  - Wyk, Roelof D. van
A1  - Lambert, Gavin W.
A1  - Vilser, Walthard
A1  - Ziemssen, Tjalf
A1  - Schlaich, Markus P.
A1  - Smith, Wayne
A1  - Magnusson, Martin
A1  - Wentzel, Annemarie
A1  - Myburgh, Carlien E.
A1  - Steyn, Hendrik S.
A1  - Malan, Nico T.
T1  - Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study
JF  - Cardiovascular Journal of Africa
Y1  - 2020
U6  - https://doi.org/10.5830/CVJA-2020-031
SN  - 1680-0745
VL  - 26
IS  - 31
SP  - 1
EP  - 12
PB  - Clinics Cardive Publishing
CY  - Durbanville
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Mclaughlin, Lesley A.
A1  - Rode, Anja
A1  - MacLeod, Alastair Kenneth
A1  - Henderson, Colin J.
A1  - Wolf, Roland C.
T1  - Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism
JF  - Drug Metabolism and Disposition
N2  - In humans, 75% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15%) and larger livers (20%). Changes in hepatic morphology and a decreased blood glucose (30%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.
Y1  - 2014
U6  - https://doi.org/10.1124/dmd.114.057885
SN  - 1521-009X
VL  - 42
IS  - 6
SP  - 1022
EP  - 1030
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Hartung, Frank
A1  - Horn, Uwe
A1  - Huschke, Jörg
A1  - Kampmann, Markus
T1  - Delivery of Broadcast Services in 3G Networks / Hartung, Frank ; Horn, Uwe ; Jörg Huschke ; Kampmann, Markus ; Lohmar, Thorsten ; Lundevall, Magnus
JF  - IEEE Transactions on Broastcasting. 53 (2007), H. 1 Part: 2
Y1  - 2007
SN  - 0018-9316
N1  - campusweit: http://dx.doi.org/10.1109/TBC.2007.891711
SP  - 188
EP  - 199
ER  - 
TY  - JOUR
A1  - Hartung, Frank
A1  - Kampmann, M.
A1  - Horn, U.
A1  - Huschke, J.
T1  - Delivery of Mobile TV services in 3G cellular networks / Kampmann, M. ; Hartung, F.  ; Horn, U. ; Huschke, J. ; Lohmar, T.
JF  - Elektronische Medien : Vorträge des 12. Dortmunder Fernsehseminars vom 20. bis 21. März 2007 in Dortmund / Veranst.: ITG-FKTG-Fachbereich 3 ... Wiss. Tagungsleitung: R. Kays
Y1  - 2007
SN  - 978-3-8007-3019-3
N1  - ITG-Fachbericht ; 199
SP  - 49
EP  - 52
PB  - VDE-Verl.
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Schulte-Tigges, Joschua
A1  - Matheis, Dominik
A1  - Reke, Michael
A1  - Walter, Thomas
A1  - Kaszner, Daniel
ED  - Krömker, Heidi
T1  - Demonstrating a V2X enabled system for transition of control and minimum risk manoeuvre when leaving the operational design domain
T2  - HCII 2023: HCI in Mobility, Transport, and Automotive Systems
N2  - Modern implementations of driver assistance systems are evolving from a pure driver assistance to a independently acting automation system. Still these systems are not covering the full vehicle usage range, also called operational design domain, which require the human driver as fall-back mechanism. Transition of control and potential minimum risk manoeuvres are currently research topics and will bridge the gap until full autonomous vehicles are available. The authors showed in a demonstration that the transition of control mechanisms can be further improved by usage of communication technology. Receiving the incident type and position information by usage of standardised vehicle to everything (V2X) messages can improve the driver safety and comfort level. The connected and automated vehicle’s software framework can take this information to plan areas where the driver should take back control by initiating a transition of control which can be followed by a minimum risk manoeuvre in case of an unresponsive driver. This transition of control has been implemented in a test vehicle and was presented to the public during the IEEE IV2022 (IEEE Intelligent Vehicle Symposium) in Aachen, Germany.
KW  - V2X
KW  - Transiton of Control
KW  - Minimum Risk Manoeuvre
KW  - Operational Design Domain
KW  - Connected Automated Vehicle
Y1  - 2023
SN  - 978-3-031-35677-3 (Print)
SN  - 978-3-031-35678-0 (Online)
U6  - https://doi.org/10.1007/978-3-031-35678-0_12
N1  - 5th International Conference, MobiTAS 2023, Held as Part of the 25th HCI International Conference, HCII 2023, Copenhagen, Denmark, July 23–28, 2023.
SP  - 200
EP  - 210
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Radkowitsch, H.
A1  - Lang, E. W.
A1  - Lüdemann, H.-D.
T1  - Density dependence of the molecular dynamics of fluid CH3F and CF3H studied by NMR / H. Radkowitsch, F. X.  Prielmeier, E. W. Lang and H.-D. Lüdemann
JF  - Physica B+C. 139-140 (1986)
Y1  - 1986
SN  - 0921-4526
SP  - 96
EP  - 99
ER  -