TY - JOUR A1 - Choi, Chang-Hoon A1 - Felder, Tim A1 - Felder, Jörg A1 - Tellmann, Lutz A1 - Hong, Suk-Min A1 - Wegener, Hans-Peter A1 - Shah, N Jon A1 - Ziemons, Karl T1 - Design, evaluation and comparison of endorectal coils for hybrid MR-PET imaging of the prostate JF - Physics in Medicine & Biology N2 - Prostate cancer is one of the most common cancers among men and its early detection is critical for its successful treatment. The use of multimodal imaging, such as MR-PET, is most advantageous as it is able to provide detailed information about the prostate. However, as the human prostate is flexible and can move into different positions under external conditions, it is important to localise the focused region-of-interest using both MRI and PET under identical circumstances. In this work, we designed five commonly used linear and quadrature radiofrequency surface coils suitable for hybrid MR-PET use in endorectal applications. Due to the endorectal design and the shielded PET insert, the outer face of the coils investigated was curved and the region to be imaged was outside the volume of the coil. The tilting angles of the coils were varied with respect to the main magnetic field direction. This was done to approximate the various positions from which the prostate could be imaged. The transmit efficiencies and safety excitation efficiencies from simulations, together with the signal-to-noise ratios from the MR images were calculated and analysed. Overall, it was found that the overlapped loops driven in quadrature were superior to the other types of coils we tested. In order to determine the effect of the different coil designs on PET, transmission scans were carried out, and it was observed that the differences between attenuation maps with and without the coils were negligible. The findings of this work can provide useful guidance for the integration of such coil designs into MR-PET hybrid systems in the future. Y1 - 2020 U6 - https://doi.org/10.1088/1361-6560/ab87f8 SN - 0031-9155 VL - 65 IS - 11 PB - IOP CY - Bristol ER - TY - CHAP A1 - Ostkotte, Sebastian A1 - Peters, Constantin A1 - Hüning, Felix A1 - Bragard, Michael T1 - Design, implementation and verification of an rotational incremental position encoder based on the magnetic Wiegand effect T2 - 2022 ELEKTRO (ELEKTRO) N2 - This paper covers the use of the magnetic Wiegand effect to design an innovative incremental encoder. First, a theoretical design is given, followed by an estimation of the achievable accuracy and an optimization in open-loop operation. Finally, a successful experimental verification is presented. For this purpose, a permanent magnet synchronous machine is controlled in a field-oriented manner, using the angle information of the prototype. KW - Position Encoder KW - Rotational Encoder KW - Wiegand Effect KW - Angle Sensor KW - Incremental Encoder Y1 - 2022 SN - 978-1-6654-6726-1 SN - 978-1-6654-6727-8 U6 - https://doi.org/10.1109/ELEKTRO53996.2022.9803477 SN - 2691-0616 N1 - 2022 ELEKTRO (ELEKTRO), 23-26 Mai 2022, Krakow, Poland. PB - IEEE ER - TY - JOUR A1 - Leurs, Ulrike A1 - Mezo, Gabor A1 - Öhlschläger, Peter A1 - Orban, Erika A1 - Marquard, Andrea A1 - Manea, Marilena T1 - Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety JF - Peptide Science N2 - Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect. Y1 - 2012 U6 - https://doi.org/10.1002/bip.21640 SN - 1097-0282 VL - 98 IS - 1 SP - 1 EP - 10 PB - Wiley CY - New York, NY ER - TY - CHAP A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Lorenz, Ulf A1 - Pelz, Peter F. A1 - Pöttgen, Philipp ED - Lübbecke, Marco E. ED - Koster, Arie ED - Letmathe, Peter ED - Madlener, Reihard ED - Preis, Britta ED - Walther, Grit T1 - Designing a feedback control system via mixed-integer programming T2 - Operations Research Proceedings 2014: Selected Papers of the Annual International Conference of the German Operations Research N2 - Pure analytical or experimental methods can only find a control strategy for technical systems with a fixed setup. In former contributions we presented an approach that simultaneously finds the optimal topology and the optimal open-loop control of a system via Mixed Integer Linear Programming (MILP). In order to extend this approach by a closed-loop control we present a Mixed Integer Program for a time discretized tank level control. This model is the basis for an extension by combinatorial decisions and thus for the variation of the network topology. Furthermore, one is able to appraise feasible solutions using the global optimality gap. KW - Optimal Topology KW - Controller Parameter KW - Level Control System KW - Technical Operation Research KW - Optimal Closed Loop Y1 - 2016 SN - 978-3-319-28695-2 U6 - https://doi.org/10.1007/978-3-319-28697-6_18 SP - 121 EP - 127 PB - Springer CY - Cham ER - TY - JOUR A1 - Bitz, Andreas A1 - Felder, Jorg A1 - Wittig, Tilmann T1 - Designing MRI Coils with Aid of Simulation JF - Microwaves & RF Y1 - 2013 SN - 0745-2993 VL - 52 IS - 7 SP - 56 PB - Penton CY - Cleveland, Ohio ER - TY - JOUR A1 - Bindal, Gaurav A1 - Sharma, Sparsh A1 - Janser, Frank A1 - Neu, Eugen T1 - Detailed analysis of variables affecting wing kinematics of bat flight JF - SAE International Journal of Aerospace Y1 - 2013 U6 - https://doi.org/10.4271/2013-01-9003 SN - 1946-3901 VL - 6 IS - 2 SP - 811 EP - 818 ER - TY - CHAP A1 - Rochefort, E. de A1 - Verver, M. A1 - Grunendahl, A. A1 - Mooi, H. A1 - Butenweg, Christoph T1 - Detailed modelling of the lumbar spine for investigation of low back pain T2 - Digital Human Modeling for Design and Engineering Symposium : Iowa City, Iowa June 14-16, 2005. (SAE technical papers series ; 2005-1-2716) Y1 - 2005 U6 - https://doi.org/10.4271/2005-01-2716 SN - 0096-736X SP - 1 EP - 11 PB - SAE International CY - Warrendale, Pa. ER - TY - JOUR A1 - Rochefort, E. de A1 - Verver, M. A1 - Grunendahl, A. A1 - Mooi, H. A1 - Butenweg, Christoph T1 - Detailed modelling of the lumbar spine for investigations of low back pain JF - SAE transactions : papers presented at Society and Section meetings / Society of Automotive Engineers Y1 - 2005 SN - 0096-736X VL - Volume 114 IS - Part 7 SP - 788 EP - 796 ER - TY - JOUR A1 - Frauenrath, Tobias A1 - Fuchs, Katharina A1 - Dieringer, Matthias A. A1 - Özerdem, Celal A1 - Patel, Nishan A1 - Renz, Wolfgang A1 - Greiser, Andreas A1 - Elgeti, Thomas A1 - Niendorf, Thoralf T1 - Detailing the use of magnetohydrodynamic effects for synchronization of MRI with the cardiac cycle: A feasibility study JF - Journal of Magnetic Resonance Imaging N2 - Purpose: To investigate the feasibility of using magnetohydrodynamic (MHD) effects for synchronization of magnetic resonance imaging (MRI) with the cardiac cycle. Materials and Methods: The MHD effect was scrutinized using a pulsatile flow phantom at B0 = 7.0 T. MHD effects were examined in vivo in healthy volunteers (n = 10) for B0 ranging from 0.05–7.0 T. Noncontrast-enhanced MR angiography (MRA) of the carotids was performed using a gated steady-state free-precession (SSFP) imaging technique in conjunction with electrocardiogram (ECG) and MHD synchronization. Results: The MHD potential correlates with flow velocities derived from phase contrast MRI. MHD voltages depend on the orientation between B0 and the flow of a conductive fluid. An increase in the interelectrode spacing along the flow increases the MHD potential. In vivo measurement of the MHD effect provides peak voltages of 1.5 mV for surface areas close to the common carotid artery at B0 = 7.0 T. Synchronization of MRI with the cardiac cycle using MHD triggering is feasible. MHD triggered MRA of the carotids at 3.0 T showed an overall image quality and richness of anatomic detail, which is comparable to ECG-triggered MRAs. Conclusion: This feasibility study demonstrates the use of MHD effects for synchronization of MR acquisitions with the cardiac cycle. J. Magn. Reson. Imaging 2012;36:364–372. © 2012 Wiley Periodicals, Inc. Y1 - 2012 U6 - https://doi.org/10.1002/jmri.23634 SN - 1522-2586 VL - 36 IS - 2 SP - 364 EP - 372 PB - Wiley-Liss CY - New York ER - TY - JOUR A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Detecting Both Physical and (Bio-)Chemical Parameters by Means of ISFET Devices JF - Electroanalysis. 16 (2004), H. 22 Y1 - 2004 SN - 1040-0397 SP - 1863 EP - 1872 ER -