TY - JOUR A1 - Arreola, Julio A1 - Keusgen, Michael A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Combined calorimetric gas- and spore-based biosensor array for online monitoring and sterility assurance of gaseous hydrogen peroxide in aseptic filling machines JF - Biosensors and Bioelectronics Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.bios.2019.111628 SN - 0956-5663 VL - 143 IS - 111628 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Höttges, Jörg A1 - Arnold, Uwe A1 - Rouvé, Gerhard T1 - Combined Digital Image and Finite Element Analysis of Mixing in Compound Open Channel Flow / Arnold, U.; J. Höttges; G. Rouvé JF - Refined flow modelling and turbulence measurements : proceedings of the Third International Symposium Tokyo, Japan 26 - 28 July, 1988 / ed. by Y. Iwasa. Scientific Organizing Committee of the Third International Symposium on Refined Flow Modelling and Tur Y1 - 1989 SN - 4-946443-03-7 N1 - International Symposium on Refined Flow Modelling and Turbulence Measurements <3, 1988, Tōkyō> SP - 569 EP - 576 PB - Universal Acad. Press CY - Tokyo ER - TY - CHAP A1 - Horikawa, Atsushi A1 - Ashikaga, Mitsugu A1 - Yamaguchi, Masato A1 - Ogino, Tomoyuki A1 - Aoki, Shigeki A1 - Wirsum, Manfred A1 - Funke, Harald A1 - Kusterer, Karsten T1 - Combined heat and power supply demonstration of Micro-Mix Hydrogen Combustion Applied to M1A-17 Gas Turbine T2 - Proceedings of ASME Turbo Expo 2022: Turbomachinery Technical Conference and Exposition (GT2022) (Volume 3A) N2 - Kawasaki Heavy Industries, Ltd. (KHI), Aachen University of Applied Sciences, and B&B-AGEMA GmbH have investigated the potential of low NOx micro-mix (MMX) hydrogen combustion and its application to an industrial gas turbine combustor. Engine demonstration tests of a MMX combustor for the M1A-17 gas turbine with a co-generation system were conducted in the hydrogen-fueled power generation plant in Kobe City, Japan. This paper presents the results of the commissioning test and the combined heat and power (CHP) supply demonstration. In the commissioning test, grid interconnection, loading tests and load cut-off tests were successfully conducted. All measurement results satisfied the Japanese environmental regulation values. Dust and soot as well as SOx were not detected. The NOx emissions were below 84 ppmv at 15 % O2. The noise level at the site boundary was below 60 dB. The vibration at the site boundary was below 45 dB. During the combined heat and power supply demonstration, heat and power were supplied to neighboring public facilities with the MMX combustion technology and 100 % hydrogen fuel. The electric power output reached 1800 kW at which the NOx emissions were 72 ppmv at 15 % O2, and 60 %RH. Combustion instabilities were not observed. The gas turbine efficiency was improved by about 1 % compared to a non-premixed type combustor with water injection as NOx reduction method. During a total equivalent operation time of 1040 hours, all combustor parts, the M1A-17 gas turbine as such, and the co-generation system were without any issues. KW - industrial gas turbine KW - combustor development KW - fuels KW - hydrogen KW - emission Y1 - 2022 SN - 978-0-7918-8599-4 U6 - http://dx.doi.org/10.1115/GT2022-81620 N1 - ASME Turbo Expo 2022: Turbomachinery Technical Conference and Exposition June 13–17, 2022 Rotterdam, Netherlands PB - American Society of Mechanical Engineers CY - Fairfield ER - TY - JOUR A1 - Havermann, Marc A1 - Beylich, A. E. T1 - Combined Measurement of Velocity, Temperature and Pressure in Compressible Gas Flows Using Laser-Induced Iodine Fluorescence / Havermann, M. ; Beylich, A. E. Y1 - 1998 N1 - 9th International Symposium on Applications of Laser Techniques to Fluid Mechanics, Lisbon (Portugal), 1998 PB - - ER - TY - JOUR A1 - Jahnke, Siegfried A1 - Menzel, Marion I. A1 - Dusschoten, Dagmar van A1 - Roeb, Gerhard W. A1 - Bühler, Jonas A1 - Minwuyelet, Senay A1 - Blümler, Peter A1 - Temperton, Vicky M. A1 - Hombach, Thomas A1 - Streun, Matthias A1 - Beer, Simone A1 - Khodaverdi, Maryam A1 - Ziemons, Karl A1 - Coenen, Heinz H. A1 - Schurr, Ulrich T1 - Combined MRI–PET dissects dynamic changes in plant structures and functions JF - The Plant Journal N2 - Unravelling the factors determining the allocation of carbon to various plant organs is one of the great challenges of modern plant biology. Studying allocation under close to natural conditions requires non-invasive methods, which are now becoming available for measuring plants on a par with those developed for humans. By combining magnetic resonance imaging (MRI) and positron emission tomography (PET), we investigated three contrasting root/shoot systems growing in sand or soil, with respect to their structures, transport routes and the translocation dynamics of recently fixed photoassimilates labelled with the short-lived radioactive carbon isotope 11C. Storage organs of sugar beet (Beta vulgaris) and radish plants (Raphanus sativus) were assessed using MRI, providing images of the internal structures of the organs with high spatial resolution, and while species-specific transport sectoralities, properties of assimilate allocation and unloading characteristics were measured using PET. Growth and carbon allocation within complex root systems were monitored in maize plants (Zea mays), and the results may be used to identify factors affecting root growth in natural substrates or in competition with roots of other plants. MRI–PET co-registration opens the door for non-invasive analysis of plant structures and transport processes that may change in response to genomic, developmental or environmental challenges. It is our aim to make the methods applicable for quantitative analyses of plant traits in phenotyping as well as in understanding the dynamics of key processes that are essential to plant performance. Y1 - 2009 SN - 1365-313X VL - 59 IS - 4 SP - 634 EP - 644 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Musholt, Petra B. A1 - Schöndorf, Thomas A1 - Pfützner, Andreas A1 - Hohberg, Cloth A1 - Kleine, Iris A1 - Fuchs, Winfried A1 - Hehenwarter, Silvia A1 - Dikta, Gerhard A1 - Kerschgens, Benedikt A1 - Forst, Thomas T1 - Combined Pioglitazone and Metformin Treatment Maintains the Beneficial Effect of Short-Term Insulin Infusion in Patients with Type 2 Diabetes: Results from a Pilot Study JF - Journal of Diabetes Science and Technology. 3 (2009), H. 6 Y1 - 2009 SN - 1932-2968 SP - 1442 EP - 1450 PB - Sage Publishing CY - London ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Roeth, Anjali A.J. A1 - Eberbeck, Dietmar A1 - Buhl, Eva Miriam A1 - Neumann, Ulf Peter A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells JF - Scientific Reports N2 - Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95% was achieved by depositing an intracellular total thermal energy with about 50% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65% after MNP were internalized inside cells. Y1 - 2018 U6 - http://dx.doi.org/10.1038/s41598-018-31553-9 SN - 2045-2322 VL - 8 IS - 1 SP - Article number 13210 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Knox, Ronald A1 - Bruggemann, Andrea A1 - Gossmann, Matthias A1 - Thomas, Ulrich A1 - Horváth, András A1 - Dragicevic, Elena A1 - Stoelzle-Feix, Sonja A1 - Fertig, Niels A1 - Jung, Alexander A1 - Raman, Aravind Hariharan A1 - Staat, Manfred A1 - Linder, Peter T1 - Combining physiological relevance and throughput for in vitro cardiac contractility measurement JF - Biophysical Journal N2 - Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these. Y1 - 2020 U6 - http://dx.doi.org/10.1016/j.bpj.2019.11.3104 SN - 0006-3495 N1 - Raman, Arayind Hariharan im Artikel unter dem Namen: Raman, Alexander H. VL - 118 IS - Issue 3, Supplement 1 SP - 570a PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Horikawa, Atsushi A1 - Okada, Kunio A1 - Yamaguchi, Masato A1 - Aoki, Shigeki A1 - Wirsum, Manfred A1 - Funke, Harald A1 - Kusterer, Karsten T1 - Combustor development and engine demonstration of micro-mix hydrogen combustion applied to M1A-17 gas turbine T2 - ASME Turbo Expo 2021: Turbomachinery Technical Conference and Exposition // Volume 3B: Combustion, Fuels, and Emissions N2 - Kawasaki Heavy Industries, LTD. (KHI) has research and development projects for a future hydrogen society. These projects comprise the complete hydrogen cycle, including the production of hydrogen gas, the refinement and liquefaction for transportation and storage, and finally the utilization in a gas turbine for electricity and heat supply. Within the development of the hydrogen gas turbine, the key technology is stable and low NOx hydrogen combustion, namely the Dry Low NOx (DLN) hydrogen combustion. KHI, Aachen University of Applied Science, and B&B-AGEMA have investigated the possibility of low NOx micro-mix hydrogen combustion and its application to an industrial gas turbine combustor. From 2014 to 2018, KHI developed a DLN hydrogen combustor for a 2MW class industrial gas turbine with the micro-mix technology. Thereby, the ignition performance, the flame stability for equivalent rotational speed, and higher load conditions were investigated. NOx emission values were kept about half of the Air Pollution Control Law in Japan: 84ppm (O2-15%). Hereby, the elementary combustor development was completed. From May 2020, KHI started the engine demonstration operation by using an M1A-17 gas turbine with a co-generation system located in the hydrogen-fueled power generation plant in Kobe City, Japan. During the first engine demonstration tests, adjustments of engine starting and load control with fuel staging were investigated. On 21st May, the electrical power output reached 1,635 kW, which corresponds to 100% load (ambient temperature 20 °C), and thereby NOx emissions of 65 ppm (O2-15, 60 RH%) were verified. Here, for the first time, a DLN hydrogen-fueled gas turbine successfully generated power and heat. KW - industrial gas turbine KW - combustor development KW - engine demonstration KW - fuels KW - hydrogen Y1 - 2021 U6 - http://dx.doi.org/10.1115/GT2021-59666 N1 - ASME Turbo Expo 2021: Turbomachinery Technical Conference and Exposition. June 7–11, 2021. Virtual, Online. Paper No: GT2021-59666, V03BT04A014 ER - TY - JOUR A1 - Sommer, F. A1 - Gerling, Ulrich A1 - Predel, Bruno T1 - Comments on 'On the evaluation of interchange energies and the equilibrium constant from mixing enthalpies of a regular associated solution' by S. Lele, G.V.S. Sastry, and P. Ramachandrarao = Kommentar zu 'Zur Berechnung der Wechselwirkungsenergien und der Gleichgewichtskonstanten aus Mischungsenthalpien in regulären assoziierten Lösungen' von S. Lele, G.V.S. Sastry und P. Ramachandrarao JF - Zeitschrift für Metallkunde : international journal of materials research and advanced techniques. Bd. 75, H. 6 Y1 - 1984 SN - 0044-3093 ; 0179-4841 SP - 449 EP - 454 ER -