TY  - JOUR
A1  - Unden, G.
A1  - Becker, S.
A1  - Bongaerts, Johannes
A1  - Holighaus, G.
A1  - Schirawski, J.
A1  - Six, S.
T1  - O2-sensing and O2-dependent gene regulation in facultatively anaerobic bacteria
JF  - Archives of microbiology
Y1  - 1995
SN  - 1432-072X (E-Journal); 0003-9276 (Print); 0302-8933 (Print)
VL  - Vol. 164
IS  - Iss. 2
SP  - 81
EP  - 90
ER  - 
TY  - JOUR
A1  - Kornfeld, Jan-Wilhelm
A1  - Baitzel, Catherina
A1  - Könner, A. Christine
A1  - Nicholls, Hayley T.
A1  - Vogt, Merly C.
A1  - Herrmanns, Karolin
A1  - Scheja, Ludger
A1  - Haumaitre, Cécile
A1  - Wolf, Anna M.
A1  - Knippschild, Uwe
A1  - Seibler, Jost
A1  - Cereghini, Silvia
A1  - Heeren, Joerg
A1  - Stoffel, Markus
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
JF  - Nature
Y1  - 2013
SN  - 0028-0836
U6  - https://doi.org/10.1038/nature11793
VL  - 494
IS  - 7435
SP  - 111
EP  - 115
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - https://doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Lieder, R. M.
A1  - Didelez, J. P.
A1  - Beuscher, H.
T1  - Observation of a New Isomer in ²¹² Po
JF  - Annual report 1978 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: A. Fässler. -
Y1  - 1979
N1  - Spezielle Berichte der Kernforschungsanlage Jülich ; 36
SP  - 38
PB  - Kernforschungsanlage
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Lieder, R. M.
A1  - Didelez, J. P.
A1  - Beuscher, H.
T1  - Observation of a New Isomer in ²¹² Po
JF  - Physical review letters
Y1  - 1978
U6  - https://doi.org/10.1103/PhysRevLett.41.742
SN  - 0031-9007
VL  - 41
IS  - 11
SP  - 742
EP  - 745
PB  - American Physical Society
CY  - Ridge, NY
ER  - 
TY  - JOUR
A1  - Rateike, Franz-Matthias
A1  - Weyer, K. G.
A1  - Wiedenmann, H.
A1  - MacGillivray, W. R.
T1  - Observation of absorptive optical bistability in a fabry-perot cavity containing multiple atomic beams /  K. G. Weyer ;  H. Wiedenmann ;  M.  Rateike ; W. R. Mac Gillivray ; P. Meystre ; H. Walther
JF  - Optics communications. 37 (1981), H. 6
Y1  - 1981
SN  - 0030-4018
SP  - 426
EP  - 430
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Neskakis, A.
A1  - Lieder, R. M.
T1  - Observation of rotation-aligned bands in the odd-odd nuclei ¹⁹⁰,¹⁹²,¹⁹⁴ Au
JF  - Physics letters / B. 80 (1979), H. 3
Y1  - 1979
SN  - 0031-9163
N1  - 2. ISSN: 0370-2693
SP  - 194
EP  - 197
ER  - 
TY  - JOUR
A1  - Förster, Arnold
A1  - Schmidt, T.
A1  - Haug, R. J.
T1  - Observation of the local structure of landau bands in a disordered conductor / T. Schmidt ; R. J. Haug ; Vladimir I. Fal'ko ... A. Förster ...
JF  - Physical review letters. 78 (1997), H. 8
Y1  - 1997
SN  - 0031-9007
N1  - ISSN der E-Ausg.: 1079-7114
SP  - 1540
EP  - 1543
ER  - 
TY  - JOUR
A1  - Samm, Doris
A1  - Faissner, H.
A1  - Frenzel, E.
A1  - Heinrigs, W.
T1  - Observation of the two-photon decay of a light penetrating particle / H. Faissner, E. Frenzel, W. Heinrigs, A. Preussger, D. Samm und U. Samm
JF  - Physics Letters B. Vol. 103 (1980), H. Issues 3
Y1  - 1980
SP  - 234
EP  - 240
ER  - 
TY  - JOUR
A1  - Blome, Hans-Joachim
A1  - Wilson, Thomas L.
T1  - Observational cosmology from the moon. Wilson, Thomas, L.; Blome, Hans-Joachim
JF  - Engineering, construction, and operations in space V : proceedings of the Fifth International Conference on Space '96, Albuquerque, New Mexico, June 1-6, 1996 / sponsored by Aerospace Division of the American Society of Civil Engineers ... [et al.]; edite
Y1  - 1996
SN  - 0-7844-0177-2
SP  - 864
EP  - 870
PB  - The Society
CY  - New York
ER  -