TY  - JOUR
A1  - Wilson, C. E.
A1  - Dickie, A. P.
A1  - Schreiter, K.
A1  - Wehr, R.
A1  - Wilson, E. M.
A1  - Bial, J.
A1  - Scheer, Nico
A1  - Wilson, I. D.
A1  - Riley, R. J.
T1  - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
JF  - Archives of Toxicology
N2  - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
Y1  - 2018
U6  - https://doi.org/10.1007/s00204-018-2212-1
SN  - 1432-0738
VL  - 92
IS  - 6
SP  - 1953
EP  - 1967
PB  - Springer
ER  - 
TY  - JOUR
A1  - Wilson, Ian D.
A1  - Wilson, Claire E.
A1  - Scheer, Nico
A1  - Dickie, A.P.
A1  - Schreiter, K.
A1  - Wilson, E. M.
A1  - Riley, R. J.
A1  - Wehr, R.
A1  - Bial, J.
T1  - The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
JF  - Biochemical pharmacology
Y1  - 2017
U6  - https://doi.org/10.1016/j.bcp.2017.03.015
SN  - 1873-2968
VL  - Volume 135
SP  - 139
EP  - 150
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Buxbaum, Bernd
A1  - Hess, Holger
A1  - Ringbeck, Thorsten
ED  - Voges, Edgar
T1  - The photonic mixer device : new perspectives in optical wireless communication
T2  - International Workshop on Optical MEMS and Integrated Optics : Universität Dortmund, Universitätskolleg Bommerholz, 11. & 12. June 2001
Y1  - 2001
N1  - International Workshop on Optical MEMS and Integrated Optics <2001, Dortmund>
SP  - (12)1
EP  - (12)5
PB  - Univ.
CY  - Dortmund
ER  - 
TY  - JOUR
A1  - Wilson, T. L.
A1  - Blome, Hans-Joachim
T1  - The Pioneer anomaly and a rotating Gödel universe
JF  - Advances in Space Research
Y1  - 2009
SN  - 0273-1177
VL  - 44
IS  - 11
SP  - 1345
EP  - 1353
ER  - 
TY  - JOUR
A1  - Blome, Hans-Joachim
A1  - Kosbow, Michael
T1  - The Pioneer Anomaly in the context of non-Newtonian Gravity
JF  - International Astronautical Congress : final papers : October 17-21, 2005, Fukuoka, Japan
Y1  - 2005
N1  - Proceedings IAC-2005-C1.P.20 ;International Astronautical Congress ; (56, 2005, Fukuoka, Japan)
SP  - 20
EP  - 20
PB  - International Astronautical Federation
CY  - Paris
ER  - 
TY  - JOUR
A1  - Eggert, Mathias
A1  - Knackstedt, Ralf
A1  - Fleischer, Stefan
A1  - Becker, Jörg
T1  - The Potential of Configurative Reference Modeling for Business to Government Reporting – A Modeling Technique and its Evaluation
JF  - e-Service Journal
Y1  - 2013
SN  - 1528-8234
VL  - 9
IS  - 1
SP  - 28
EP  - 59
PB  - Indiana University Press
CY  - Bloomington
ER  - 
TY  - CHAP
A1  - Hoffmann, Katharina
A1  - Nieren, Monika
A1  - Gäb, Martina
A1  - Kasper, Anna
A1  - Elbers, Gereon
T1  - The potential of near infrared spectroscopy (NIRS) for the environmental biomonitoring of plants
T2  - International conference on Life Sciences and Technology
N2  - In the current environmental condition, the increase in pollution of the air, water, and soil indirectly will induce plants stress and decrease vegetation growth rate. These issues pay more attention to be solved by scientists worldwide. The higher level of chemical pollutants also induced the gradual changes in plants metabolism and decreased enzymatic activity. Importantly, environmental biomonitoring may play a pivotal contribution to prevent biodiversity degradation and plants stress due to pollutant exposure. Several previous studies have been done to monitor the effect of environmental changes on plants growth. Among that, Near Infrared spectroscopy (NIRS) offers an alternative way to observe the significant alteration of plant physiology caused by environmental damage related to pollution. Impairment of photosynthesis, nutrient and oxidative imbalances, and mutagenesis.
Y1  - 2019
U6  - https://doi.org/10.1088/1755-1315/276/1/012009
SN  - 1755-1315
N1  - IOP Conference Series: Earth and Environmental Science : 276
VL  - 276
IS  - 012009
SP  - 1
EP  - 3
ER  - 
TY  - CHAP
A1  - Schleupen, Josef
A1  - Engemann, Heiko
A1  - Bagheri, Mohsen
A1  - Kallweit, Stephan
T1  - The potential of SMART climbing robot combined with a weatherproof cabin for rotor blade maintenance
T2  - 17th European Conference on Composite Materials – ECCM, Munich, Germany
Y1  - 2016
N1  - ECCM 17
SP  - 1
EP  - 8
ER  - 
TY  - CHAP
A1  - Brandini, Frederico P.
A1  - Baumann, Marcus
T1  - The potential role of melted 'brown ice' as sources of chelators and ammonia to the surface waters of the Weddell Sea, Antarctica
T2  - Proceedings of the NIPR Symposium on Polar Biology : 10
Y1  - 1997
SN  - 0914-563X
SP  - 1
EP  - 13
CY  - Tokyo
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Lang, E. W.
A1  - Speedy, R. J.
A1  - Lüdemann, H.-D.
T1  - The pressure Dependence of Self Diffusion in Supercooled Light and Heavy Water / F.X. Prielmeier, E .W. Lang, R. J. Speedy, H.-D. Lüdemann
JF  - Berichte der Bunsen-Gesellschaft für Physikalische Chemie. 92 (1988)
Y1  - 1988
SN  - 0005-9021
SP  - 1111
ER  -