TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Kayser, Peter
T1  - Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume / Temiz, Aysegül ;  Kayser, Peter
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 497
EP  - 508
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Akimbekov, N. Sh.
A1  - Zhubanova, A. A.
A1  - Mansurov, Z. A.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Use of Carbonized Rise Shell for the local treatment of wounds
JF  - Eurasian ChemTech Journal
N2  - On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.
Y1  - 2010
U6  - http://dx.doi.org/10.18321/ectj35
SN  - 2522-4867
VL  - 12
IS  - 2
SP  - 133
EP  - 138
PB  - Institute of Combustion Problems
CY  - Almaty
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Akimbekov, N.
A1  - Turalieva, M.
A1  - Mansurov, Z.
A1  - Temiz Artmann, Aysegül
A1  - Eshibaev, A.
A1  - Zhubanova, A.
T1  - Usage of Carbonized Plant Wastes for Purification of Aqueous Solutions
JF  - Journal of Industrial Technology and Engineering
Y1  - 2013
VL  - 2
IS  - 07
SP  - 47
EP  - 54
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - The emperor's new body : seeking for a blueprint of limb regeneration in humans
JF  - Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.
Y1  - 2011
SN  - 978-3-642-11864-7
SP  - 3
EP  - 37
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Cavdar, C.
A1  - Yenicerioglu, Y.
A1  - Caliskan, S.
T1  - The effects of intravenous iron treatment on oxidant stress and erythrocyte deformability in haemodialysis patients. Cavdar, C.; Temiz, A.; Yenicerioglu, Y.; Caliskan, S.; Celik, A.; Sifil, A.; Onvural, B.; Camsari, T.
JF  - Scandinavian Journal of Urology and Nephrology. 37 (2003), H. 1
Y1  - 2003
SN  - 0036-5599
SP  - 77
EP  - 82
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Yolcuoglu, B.
A1  - Onal, M. A.
A1  - Sipahi, O.
T1  - The effect of skin transplantation on tumour growth in mice. Yolcuoglu, B.; Onal, M. A.; Sipahi, O.; Temiz, A.; Pekcetin, C.; Acikgöz, O.; Kar,  H.; Güre A.
JF  - The American Journal of Surgery. 178 (1999), H. 4
Y1  - 1999
SN  - 0002-9610
SP  - 329
EP  - 330
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Saklamaz, Ali
A1  - Comlekci, Abdurrahman
A1  - Caliskan, Sezer
T1  - The beneficial effects of lipid-lowering drugs beyond lipid-lowering effects: A comparative study with pravastatin, atorvastatin, and fenofibrate in patients with type IIa and type IIb hyperlipidemia / Saklamaz, Ali ; Comlekci, Abdurrahman ; Temiz, Aysegu
JF  - Metabolism. 54 (2005), H. 5
Y1  - 2005
SN  - 0026-0495
SP  - 677
EP  - 681
ER  - 
TY  - JOUR
A1  - Zerlin, Kay
A1  - Kasischke, Nicole
A1  - Digel, Ilya
A1  - Maggakis-Kelemen, Christina
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Linder, Peter
A1  - Artmann, Gerhard
T1  - Structural transition temperature of hemoglobins correlates with species’ body temperature
JF  - European Biophysics Journal. 37 (2007), H. 1
Y1  - 2007
SN  - 1432-1017
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Frotscher, Ralf
A1  - Muanghong, Danita
A1  - Dursun, Gözde
A1  - Goßmann, Matthias
A1  - Temiz Artmann, Aysegül
A1  - Staat, Manfred
T1  - Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue
JF  - Journal of Biomechanics
N2  - We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.
KW  - hiPS cardiomyocytes
KW  - Homogenization
KW  - Hodgkin–Huxley models
KW  - Frequency adaption
KW  - Electromechanical modeling
KW  - Drug simulation
KW  - Computational biomechanics
KW  - Cardiac tissue
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.jbiomech.2016.01.039
SN  - 0021-9290 (Print)
SN  - 1873-2380 (Online)
VL  - 49
IS  - 12
SP  - 2428
EP  - 2435
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kurulgan Demirci, Eylem
A1  - Demirci, Taylan
A1  - Linder, Peter
A1  - Trzewik, Jürgen
A1  - Gierkowski, Jessica Ricarda
A1  - Gossmann, Matthias
A1  - Kayser, Peter
A1  - Porst, Dariusz
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells
JF  - Journal of Bioscience and Bioengineering
N2  - All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.
KW  - Cell permeability
KW  - Cellular force
KW  - Endothelial cells
KW  - Recombinant activated protein C
KW  - Lipopolysaccharide
KW  - Contractile tension
KW  - CellDrum
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.jbiosc.2012.03.019
SN  - 1347-4421
VL  - 113
IS  - 2
SP  - 212
EP  - 219
PB  - Elsevier
CY  - Amsterdam
ER  -