TY - CHAP A1 - Burger, Ulrich A1 - Kirsch, Ansgar A1 - Marcher, Thomas A1 - Höser, Sebastian T1 - Geologisch-geotechnischer Planungsprozess von Tunnelbauten mit Schwerpunkt tiefliegender Tunnel T2 - Beton-Kalender ; Bd. 103: Unterirdisches Bauen, Grundbau, Eurocode 7 Y1 - 2014 SN - 978-3-433-03051-6 ; 978-3-433-60335-2 ; 978-3-433-60508-0 ; 3-433-60508-4 SP - 37 EP - 62 PB - Ernst CY - Berlin ER - TY - JOUR A1 - Scheer, Nico A1 - Wolf, C. Roland T1 - Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications JF - Xenobiotica N2 - 1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug–drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug–drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed. KW - transporters KW - human metabolites KW - drug metabolising enzymes KW - drug–drug interactions KW - bioavailability Y1 - 2014 U6 - https://doi.org/10.3109/00498254.2013.815831 SN - 1366-5928 VL - 44 IS - 2 SP - 96 EP - 108 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Thomas, Axel T1 - Generation Y JF - P.T. : Magazin für Wirtschaft und Gesellschaft Y1 - 2014 SN - 1860-501X VL - 10 IS - 3 SP - 6 EP - 9 PB - OPS Netzwerk CY - Leipzig ER - TY - CHAP A1 - Laack, Walter van T1 - Gefahren heutiger neurologischer Schlussfolgerungen für ethische Verantwortung T2 - Ethik und Moral in Staat, Wirtschaft und Gesellschaft : 5. Rotary-Tag, 14.-15.2.2014, Kleve Y1 - 2014 SN - 978-3-944011-21-9 SP - 98 EP - 114 PB - Edition Virgines CY - Lingen ER - TY - JOUR A1 - Wilke, Thomas T1 - Gebaute Geschichte in Turin JF - Kunsttexte.de N2 - Städte sind Stein gewordene Geschichte. Ihre realisierte Form ermöglicht Geschichte zu erleben und die Stadtentwicklung nachzuvollziehen. Besonders in Turin ist ablesbar, wie das Haus Savoyen den Ausbau der neuen Hauptstadt zu einer der führenden Barockmetropolen Europas beeinflusste. Y1 - 2014 U6 - https://doi.org/10.18452/7197 SN - 1618-8101 VL - 2014 IS - 1 PB - Humboldt-Universität zu Berlin CY - Berlin ER - TY - JOUR A1 - Wollert, Jörg T1 - Funkstandards für Sensornetzwerke JF - Elektronik : Fachmedium für industrielle Anwender und Entwickler Y1 - 2014 SN - 0013-5658 VL - Bd. 63 IS - H. 12 SP - 36 EP - 41 PB - WEKA-Fachmedien CY - Haar ER - TY - JOUR A1 - Huber, M. A1 - Streblow, R. A1 - Müller, D. A1 - Lange, S. A1 - Joneleit, R. A1 - Sefker, T. A1 - Rau, Sebastian A1 - Wollert, Jörg T1 - Funksignalübertragung in Luftleitungen JF - HLH : Lüftung, Klima, Heizung, Sanitär, Gebäudetechnik Y1 - 2014 SN - 1436-5103 VL - Bd. 65 IS - H. 7/8 SP - 36 EP - 40 ER - TY - JOUR A1 - Stulpe, Werner T1 - From the attempt of certain classical reformulations of quantum mechanics to quasi-probability representations JF - Journal of Mathematical Physics N2 - The concept of an injective affine embedding of the quantum states into a set of classical states, i.e., into the set of the probability measures on some measurable space, as well as its relation to statistically complete observables is revisited, and its limitation in view of a classical reformulation of the statistical scheme of quantum mechanics is discussed. In particular, on the basis of a theorem concerning a non-denseness property of a set of coexistent effects, it is shown that an injective classical embedding of the quantum states cannot be supplemented by an at least approximate classical description of the quantum mechanical effects. As an alternative approach, the concept of quasi-probability representations of quantum mechanics is considered. Y1 - 2014 U6 - https://doi.org/10.1063/1.4861939 SN - 222-488 N1 - bereits unter gleichem Titel aufgenommen bei arxiv : http://arxiv.org/pdf/1307.2314.pdf VL - 55 IS - 1 PB - AIP Publishing CY - College Park, Md. ER - TY - CHAP A1 - Oberländer, Jan A1 - Kirchner, Patrick A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Flexible polyimide-based calorimetric gas sensors for monitoring hy-drogen peroxide in sterilisation processes of aseptic filling machines T2 - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250) Y1 - 2014 SN - 978-3-8007-3622-5 SP - 1 EP - 4 PB - VDE-Verl. CY - Düsseldorf ER - TY - JOUR A1 - Pham, Phu Tinh A1 - Staat, Manfred T1 - FEM-based shakedown analysis of hardening structures JF - Asia Pacific journal on computational engineering N2 - This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature. Y1 - 2014 U6 - https://doi.org/10.1186/2196-1166-1-4 SN - 2196-1166 (E-Journal) IS - 1 SP - Article No. 4 PB - SpringerOpen CY - Berlin ER -