TY  - JOUR
A1  - Winckler, Silvia
A1  - Krueger, Rolf
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Fischer, Rainer
A1  - Biselli, Manfred
T1  - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach
JF  - Bioprocess and biosystems engineering
N2  - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Y1  - 2014
U6  - https://doi.org/10.1007/s00449-013-1062-8
SN  - 1615-7591 (Print) 1615-7605 (Online)
VL  - 37
IS  - 5
SP  - 901
EP  - 912
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - CHAP
A1  - Schirra, Julian
A1  - Watmuff, Jon
A1  - Bauschat, J.-Michael
T1  - A relative assessment of existing potential-methodologies to accurately estimate the induced drag of highly non-planar lifting systems
T2  - Advanced aero concepts, design and operations : Applied Aerodynamics Conference  : July 22 -24, 2014, Bristol, UK
Y1  - 2014
SP  - 1
EP  - 13
ER  - 
TY  - CHAP
A1  - Al-Kaidy, Huschyar
A1  - Ulber, Roland
A1  - Tippkötter, Nils
T1  - A platform technology for the automated reaction control in magnetizable micro-fluidic droplets
T2  - Biomaterials - made in bioreactors : book of abstracts, May 26 - 28, 2014, Radisson Blu Park Hotel and Conference Dentre, Radebeul, Germany
Y1  - 2014
SP  - 21
EP  - 22
PB  - DECHEMA
CY  - Frankfurt am Main
ER  - 
TY  - JOUR
A1  - Yang, Peng-Fei
A1  - Kriechbaumer, Andreas
A1  - Albracht, Kirsten
A1  - Sanno, Maximilian
A1  - Ganse, Bergita
A1  - Koy, Timmo
A1  - Shang, Peng
A1  - brüggemann, Gert-Peter
A1  - Müller, Lars Peter
A1  - Rittweger, Jörn
T1  - A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans
JF  - Journal of Orthopaedic Translation
Y1  - 2014
U6  - https://doi.org/10.1016/j.jot.2014.07.078
SN  - 2214-0328
SN  - 2214-031X
VL  - 2
IS  - 4
SP  - 238
EP  - 238
PB  - Elsevier
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Tran, Ngoc Trinh
A1  - Staat, Manfred
A1  - Stavroulakis, G. E.
ED  - Onate, E.
T1  - A multicriteria method for truss optimization
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - CHAP
A1  - Duong, Minh Tuan
A1  - Staat, Manfred
ED  - Onate, E.
T1  - A face-based smoothed finite element method for hyperelastic models and tissue growth
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - CHAP
A1  - Bhattarai, Aroj
A1  - Frotscher, Ralf
A1  - Sora, M.-C.
A1  - Staat, Manfred
ED  - Onate, E.
T1  - A 3D finite element model of the female pelvic floor for the reconstruction of urinary incontinence
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - RPRT
A1  - Hoepner, Gert
A1  - Siers, Carsten
T1  - 6. Studie Vertriebskompass / durchgeführt von der FH Aachen und der Siers & Collegen GmbH
Y1  - 2014
PB  - FH Aachen
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Gebhardt, Andreas
A1  - Fateri, Miranda
T1  - 3D-Drucken und die Anwendungen
JF  - RTejournal - Forum für Rapid Technologie
Y1  - 2014
SN  - 1614-0923
VL  - 11 (2014)
IS  - 1
SP  - 1
EP  - 9
ER  - 
TY  - BOOK
A1  - Gebhardt, Andreas
T1  - 3D-Drucken : Grundlagen und Anwendungen des Additive Manufacturing (AM)
Y1  - 2014
SN  - 978-3-446-44238-2 ; 978-3-446-44237-5
PB  - Hanser
CY  - München
ER  -