TY - CHAP A1 - Milkova, Kristina A1 - Butenweg, Christoph A1 - Dumova-Jovanoska, Elena T1 - Methodology for development of seismic vulnerability curve for existing unreinforced Masonry buildings T2 - 17th World Conference on Earthquake Engineering, Sendai, Japan, September 27 to October 2, 2021. N2 - Seismic behavior of an existing unreinforced masonry building built pre-modern code, located in the City of Ohrid, Republic of North Macedonia has been investigated in this paper. The analyzed school building is selected as an archetype in an ongoing project named “Seismic vulnerability assessment of existing masonry structures in Republic of North Macedonia (SeismoWall)”. Two independent segments were included in this research: Seismic hazard assessment by creating a cite specific response spectra and Seismic vulnerability definition by creating a region - specific series of vulnerability curves for the chosen building topology. A reliable Seismic Hazard Assessment for a selected region is a crucial point for performing a seismic risk analysis of a characteristic building class. In that manner, a scenario – based method that incorporates together the knowledge of tectonic style of the considered region, the active fault characterization, the earth crust model and the historical seismicity named Neo Deterministic approach is used for calculation of the response spectra for the location of the building. Variations of the rupturing process are taken into account in the nucleation point of the rupture, in the rupture velocity pattern and in the istribution of the slip on the fault. The results obtained from the multiple scenarios are obtained as an envelope of the response spectra computed for the cite using the procedure Maximum Credible Seismic Input (MCSI). Capacity of the selected building has been determined by using nonlinear static analysis. MINEA software (SDA Engineering) was used for verification of the structural safety of the chosen unreinforced masonry structure. In the process of optimization of the number of samples, computational cost required in a Monte Carlo simulation is significantly reduced since the simulation is performed on a polynomial response surface function for prediction of the structural response. Performance point, found as the intersection of the capacity of the building and the spectra used, is chosen as a response parameter. Five levels of damage limit states based on the capacity curve of the building are defined in dependency on the yield displacement and the maximum displacement. Maximum likelihood estimation procedure is utilized in the process of vulnerability curves determination. As a result, region specific series of vulnerability curves for the chosen type of masonry structures are defined. The obtained probabilities of exceedance a specific damage states as a result from vulnerability curves are compared with the observed damages happened after the earthquake in July 2017 in the City of Ohrid, North Macedonia. KW - Masonry structures KW - Vulnerability Curves KW - Capacity Curve KW - Neo-Deterministic KW - Seismic Hazard Y1 - 2020 N1 - Die Konferenz war ursprünglich für den 13-18 September 2020 angesetzt. ER - TY - JOUR A1 - Bayer, Robin A1 - Temiz Artmann, Aysegül A1 - Digel, Ilya A1 - Falkenstein, Julia A1 - Artmann, Gerhard A1 - Creutz, Till A1 - Hescheler, Jürgen T1 - Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model JF - Cellular Physiology and Biochemistry N2 - Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis. Y1 - 2020 U6 - http://dx.doi.org/10.33594/000000225 SN - 1421-9778 VL - 54 SP - 371 EP - 383 PB - Cell Physiol Biochem Press CY - Düsseldorf ER - TY - JOUR A1 - Finger, Felix A1 - Götten, Falk A1 - Braun, Carsten A1 - Bil, Cees T1 - Mass, primary energy, and cost: the impact of optimization objectives on the initial sizing of hybrid-electric general aviation aircraft JF - CEAS Aeronautical Journal N2 - For short take-off and landing (STOL) aircraft, a parallel hybrid-electric propulsion system potentially offers superior performance compared to a conventional propulsion system, because the short-take-off power requirement is much higher than the cruise power requirement. This power-matching problem can be solved with a balanced hybrid propulsion system. However, there is a trade-off between wing loading, power loading, the level of hybridization, as well as range and take-off distance. An optimization method can vary design variables in such a way that a minimum of a particular objective is attained. In this paper, a comparison between the optimization results for minimum mass, minimum consumed primary energy, and minimum cost is conducted. A new initial sizing algorithm for general aviation aircraft with hybrid-electric propulsion systems is applied. This initial sizing methodology covers point performance, mission performance analysis, the weight estimation process, and cost estimation. The methodology is applied to the design of a STOL general aviation aircraft, intended for on-demand air mobility operations. The aircraft is sized to carry eight passengers over a distance of 500 km, while able to take off and land from short airstrips. Results indicate that parallel hybrid-electric propulsion systems must be considered for future STOL aircraft. Y1 - 2020 U6 - http://dx.doi.org/10.1007/s13272-020-00449-8 SN - 1869-5590 N1 - Corresponding author: Felix Finger VL - 2020 IS - 11 SP - 713 EP - 730 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Schmidt, Aaron C. A1 - Turgut, Hatice A1 - Le, Dao A1 - Beloqui, Ana A1 - Delaittre, Guillaume T1 - Making the best of it: nitroxide-mediated polymerization of methacrylates via the copolymerization approach with functional styrenics JF - Polymer Chemistry N2 - The SG1-mediated solution polymerization of methyl methacrylate (MMA) and oligo(ethylene glycol) methacrylate (OEGMA, Mₙ = 300 g mol⁻¹) in the presence of a small amount of functional/reactive styrenic comonomer is investigated. Moieties such as pentafluorophenyl ester, triphenylphosphine, azide, pentafluorophenyl, halide, and pyridine are considered. A comonomer fraction as low as 5 mol% typically results in a controlled/living behavior, at least up to 50% conversion. Chain extensions with styrene for both systems were successfully performed. Variation of physical properties such as refractive index (for MMA) and phase transition temperature (for OEGMA) were evaluated by comparing to 100% pure homopolymers. The introduction of an activated ester styrene derivative in the polymerization of OEGMA allows for the synthesis of reactive and hydrophilic polymer brushes with defined thickness. Finally, using the example of pentafluorostyrene as controlling comonomer, it is demonstrated that functional PMMA-b-PS are able to maintain a phase separation ability, as evidenced by the formation of nanostructured thin films. Y1 - 2020 U6 - http://dx.doi.org/10.1039/C9PY01458F VL - 11 IS - 2 SP - 593 EP - 604 PB - Royal Society of Chemistry (RSC) CY - Cambridge ER - TY - JOUR A1 - Orzada, Stephan A1 - Fiedler, Thomas M. A1 - Bitz, Andreas A1 - Ladd, Mark E. A1 - Quick, Harald H. T1 - Local SAR compression with overestimation control to reduce maximum relative SAR overestimation and improve multi-channel RF array performance JF - Magnetic Resonance Materials in Physics, Biology and Medicine N2 - Objective In local SAR compression algorithms, the overestimation is generally not linearly dependent on actual local SAR. This can lead to large relative overestimation at low actual SAR values, unnecessarily constraining transmit array performance. Method Two strategies are proposed to reduce maximum relative overestimation for a given number of VOPs. The first strategy uses an overestimation matrix that roughly approximates actual local SAR; the second strategy uses a small set of pre-calculated VOPs as the overestimation term for the compression. Result Comparison with a previous method shows that for a given maximum relative overestimation the number of VOPs can be reduced by around 20% at the cost of a higher absolute overestimation at high actual local SAR values. Conclusion The proposed strategies outperform a previously published strategy and can improve the SAR compression where maximum relative overestimation constrains the performance of parallel transmission. Y1 - 2020 SN - 1352-8661 U6 - http://dx.doi.org/10.1007/s10334-020-00890-0 IS - 34 (2021) SP - 153 EP - 164 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Bensberg, Frank A1 - Auth, Gunnar A1 - Czarnecki, Christian ED - Haake, Jörg M. T1 - Literaturanalyse mit Text Mining JF - E-Learning and Education (eleed) N2 - Die Durchführung einer systematischen Literaturrecherche ist eine zentrale Kompetenz wissenschaftlichen Arbeitens und bildet daher einen festen Ausbildungsbestandteil von Bachelor- und Masterstudiengängen. In entsprechenden Lehrveranstaltungen werden Studierende zwar mit den grundlegenden Hilfsmitteln zur Suche und Verwaltung von Literatur vertraut gemacht, allerdings werden die Potenziale textanalytischer Methoden und Anwendungssysteme (Text Mining, Text Analytics) dabei zumeist nicht abgedeckt. Folglich werden Datenkompetenzen, die zur systemgestützten Analyse und Erschließung von Literaturdaten erforderlich sind, nicht hinreichend ausgeprägt. Um diese Kompetenzlücke zu adressieren, ist an der Hochschule Osnabrück eine Lehrveranstaltung konzipiert und projektorientiert umgesetzt worden, die sich insbesondere an Studierende wirtschaftswissenschaftlicher Studiengänge richtet. Dieser Beitrag dokumentiert die fachliche sowie technische Ausgestaltung dieser Veranstaltung und zeigt Potenziale für die künftige Weiterentwicklung auf. KW - E-Learning KW - Text Mining KW - Text Analytics KW - Literaturrecherche KW - Literaturanalyse Y1 - 2020 SN - 1860-7470 N1 - Volltext, nur online IS - 13 SP - 1 EP - 13 PB - FernUniversität in Hagen CY - Hagen ER - TY - BOOK A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef ED - Yoshinobu, Tatsuo ED - Schöning, Michael Josef T1 - Light-addressing and chemical imaging technologies for electrochemical sensing Y1 - 2020 SN - 978-3-03943-029-1 U6 - http://dx.doi.org/10.3390/books978-3-03943-029-1 N1 - This book is a printed edition of the Special Issue Light-Addressing and Chemical Imaging Technologies for Electrochemical Sensing that was published in Sensors PB - MDPI CY - Basel ER - TY - JOUR A1 - Welden, Rene A1 - Schöning, Michael Josef A1 - Wagner, Patrick H. A1 - Wagner, Torsten T1 - Light-Addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions JF - Sensors N2 - In this review article, we are going to present an overview on possible applications of light-addressable electrodes (LAE) as actuator/manipulation devices besides classical electrode structures. For LAEs, the electrode material consists of a semiconductor. Illumination with a light source with the appropiate wavelength leads to the generation of electron-hole pairs which can be utilized for further photoelectrochemical reaction. Due to recent progress in light-projection technologies, highly dynamic and flexible illumination patterns can be generated, opening new possibilities for light-addressable electrodes. A short introduction on semiconductor–electrolyte interfaces with light stimulation is given together with electrode-design approaches. Towards applications, the stimulation of cells with different electrode materials and fabrication designs is explained, followed by analyte-manipulation strategies and spatially resolved photoelectrochemical deposition of different material types. Y1 - 2020 U6 - http://dx.doi.org/10.3390/s20061680 SN - 1424-8220 VL - 20 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Dantism, Shahriar A1 - Röhlen, Desiree A1 - Dahmen, Markus A1 - Wagner, Torsten A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - LAPS-based monitoring of metabolic responses of bacterial cultures in a paper fermentation broth JF - Sensors and Actuators B: Chemical N2 - As an alternative renewable energy source, methane production in biogas plants is gaining more and more attention. Biomass in a bioreactor contains different types of microorganisms, which should be considered in terms of process-stability control. Metabolically inactive microorganisms within the fermentation process can lead to undesirable, time-consuming and cost-intensive interventions. Hence, monitoring of the cellular metabolism of bacterial populations in a fermentation broth is crucial to improve the biogas production, operation efficiency, and sustainability. In this work, the extracellular acidification of bacteria in a paper-fermentation broth is monitored after glucose uptake, utilizing a differential light-addressable potentiometric sensor (LAPS) system. The LAPS system is loaded with three different model microorganisms (Escherichia coli, Corynebacterium glutamicum, and Lactobacillus brevis) and the effect of the fermentation broth at different process stages on the metabolism of these bacteria is studied. In this way, different signal patterns related to the metabolic response of microorganisms can be identified. By means of calibration curves after glucose uptake, the overall extracellular acidification of bacterial populations within the fermentation process can be evaluated. Y1 - 2020 U6 - http://dx.doi.org/10.1016/j.snb.2020.128232 SN - 0925-4005 VL - 320 IS - Art. 128232 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Bronder, Thomas T1 - Label-free detection of tuberculosis DNA with capacitive field-effect biosensors Y1 - 2020 U6 - http://dx.doi.org/10.17192/z2021.0056 N1 - Dissertation, Universität, Marburg 2020 PB - Philipps-Universität Marburg CY - Marburg ER -