TY - CHAP A1 - Samuelsson, K. A1 - Scheer, Nico A1 - Wilson, I. A1 - Wolf, C.R. A1 - Henderson, C.J. ED - Chackalamannil, Samuel T1 - Genetically Humanized Animal Models T2 - Comprehensive Medicinal Chemistry III. 3rd Edition N2 - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development. KW - Chimeric liver-humanized mice KW - Drug distribution KW - Drug metabolism KW - Toxicology KW - Knockout mice Y1 - 2017 SN - 978-0-12-803201-5 U6 - https://doi.org/10.1016/B978-0-12-409547-2.12376-5 SP - 130 EP - 149 PB - Elsevier CY - Saint Louis ER - TY - CHAP A1 - Barnat, Miriam A1 - Bosse, Elke A1 - Tight, Malcolm T1 - The Guiding Role of Theory in Mixed-Methods Research: Combining Individual and Institutional Perspectives on the Transition to Higher Education T2 - Theory and Method in Higher Education Research. Vol 3 N2 - The methodological discourse of mixed-methods research offers general procedures to combine quantitative and qualitative methods for investigating complex fields of research such as higher education. However, integrating different methods still poses considerable challenges. To move beyond general recommendations for mixed-methods research, this chapter proposes to discuss methodological issues with respect to a particular research domain. Taking current studies on the transition to higher education as an example, the authors first provide an overview of the potentials and limitations of quantitative and qualitative methods in the research domain. Second, they show the need for a conceptual framework grounded in the theory of the research object to guide the integration of different methods and findings. Finally, an example study that investigates transition with regard to the interplay of the individual student and the institutional context serves to illustrate the guiding role of theory. The framework integrates different theoretical perspectives on transition, informs the selection of the research methods, and defines the nexus of the two strands that constitute the mixed-methods design. As the interplay of individual and context is of concern for teaching and learning in general, the example presented may be fruitful for the wider field of higher education research. KW - Quantitative research KW - Mixed-Methods Research KW - Transition KW - Students KW - Higher education Y1 - 2017 SN - 978-1-78743-222-2 U6 - https://doi.org/10.1108/S2056-375220170000003001 SP - 1 EP - 19 PB - Emerald Publishing Limited ER - TY - CHAP A1 - Wilke, Thomas T1 - Peyre, Marie-Josephe T2 - Allgemeines Künstler-Lexikon. Bd. 95 Y1 - 2017 SN - 978-3-11-023261-5 N1 - namentlich gekennzeichneter Lexikon-Eintrag SP - 301 EP - 302 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas T1 - Peyre, Antoine-Francois T2 - Allgemeines Künstler-Lexikon. Bd. 95 Y1 - 2017 SN - 978-3-11-023261-5 N1 - namentlich gekennzeichneter Lexikon-Eintrag SP - 300 EP - 301 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas T1 - Patte, Pierre T2 - Allgemeines Künstler-Lexikon. Bd. 94 Y1 - 2017 SN - 978-3-11-023260-8 N1 - namentlich gekennzeichneter Lexikon-Eintrag SP - 429 EP - 430 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas T1 - Ranson, Pierre T2 - Allgemeines Künstler-Lexikon. Online Y1 - 2017 N1 - namentlich gekennzeichneter Lexikon-Eintrag PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin T1 - Names of individuals T2 - European Encyclopedia of Private International Law Y1 - 2017 SN - 9781782547228 PB - Edward Elgar Publishing CY - Cheltenham, UK ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin T1 - Small Claims Regulation T2 - European Encyclopedia of Private International Law Y1 - 2017 SN - 9781782547228 PB - Edward Elgar Publishing CY - Cheltenham, UK ER - TY - CHAP A1 - Klocke, Martina A1 - Katz, Christiane T1 - Heterogenität von MINT-Studierenden als Herausforderung T2 - Tagungsband zum 3. Symposium zur Hochschullehre in den MINT-Fächern Y1 - 2017 SP - 31 EP - 36 PB - Technische Hochschule Nürnberg Georg Simon Ohm CY - Nürnberg ER - TY - CHAP A1 - Altherr, Lena A1 - Dörig, Bastian A1 - Ederer, Thorsten A1 - Pelz, Peter Franz A1 - Pfetsch, Marc A1 - Wolf, Jan T1 - A mixed-integer nonlinear program for the design of gearboxes T2 - Operations Research Proceedings 2016 N2 - Gearboxes are mechanical transmission systems that provide speed and torque conversions from a rotating power source. Being a central element of the drive train, they are relevant for the efficiency and durability of motor vehicles. In this work, we present a new approach for gearbox design: Modeling the design problem as a mixed-integer nonlinear program (MINLP) allows us to create gearbox designs from scratch for arbitrary requirements and—given enough time—to compute provably globally optimal designs for a given objective. We show how different degrees of freedom influence the runtime and present an exemplary solution. Y1 - 2017 SN - 978-3-319-55701-4 U6 - https://doi.org/10.1007/978-3-319-55702-1_31 SP - 227 EP - 233 PB - Springer CY - Cham ER -