TY  - JOUR
A1  - Ortner, Marion
A1  - Hauser, Christine
A1  - Schmaderer, Christoph
A1  - Muggenthaler, Claudia
A1  - Hapfelmeier, Alexander
A1  - Sorg, Christian
A1  - Diehl-Schmid, Janine
A1  - Kurz, Alexander
A1  - Förstl, Hans
A1  - Ikenberg, Benno
A1  - Kotliar, Konstantin
A1  - Holger, Poppert
A1  - Grimmer, Timo
T1  - Decreased vascular pulsatility in Alzheimer’s disease dementia measured by transcranial color-coded duplex sonography
JF  - Neuropsychiatric disease and treatment
N2  - Purpose: Impaired paravascular drainage of β-Amyloid (Aβ) has been proposed as a contributing cause for sporadic Alzheimer’s disease (AD), as decreased cerebral blood vessel pulsatility and subsequently reduced propulsion in this pathway could lead to the accumulation and deposition of Aβ in the brain. Therefore, we hypothesized that there is an increased impairment in pulsatility across AD spectrum.

Patients and Methods: Using transcranial color-coded duplex sonography (TCCS) the resistance and pulsatility index (RI; PI) of the middle cerebral artery (MCA) in healthy controls (HC, n=14) and patients with AD dementia (ADD, n=12) were measured. In a second step, we extended the sample by adding patients with mild cognitive impairment (MCI) stratified by the presence (MCI-AD, n=8) or absence of biomarkers (MCI-nonAD, n=8) indicative for underlying AD pathology, and compared RI and PI across the groups. To control for atherosclerosis as a confounder, we measured the arteriolar-venular-ratio of retinal vessels.

Results: Left and right RI (p=0.020; p=0.027) and left PI (p=0.034) differed between HC and ADD controlled for atherosclerosis with AUCs of 0.776, 0.763, and 0.718, respectively. The RI and PI of MCI-AD tended towards ADD, of MCI-nonAD towards HC, respectively. RIs and PIs were associated with disease severity (p=0.010, p=0.023).

Conclusion: Our results strengthen the hypothesis that impaired pulsatility could cause impaired amyloid clearance from the brain and thereby might contribute to the development of AD. However, further studies considering other factors possibly influencing amyloid clearance as well as larger sample sizes are needed.
Y1  - 2019
U6  - https://doi.org/10.2147/NDT.S225754
SN  - 1178-2021
IS  - 15
SP  - 3487
EP  - 3499
PB  - Dove Medical Press
CY  - Albany, Auckland
ER  - 
TY  - JOUR
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Biele, Jens
A1  - Boden, Ralf Christian
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, David
T1  - Capabilities of Gossamer-1 derived small spacecraft solar sails carrying Mascot-derived nanolanders for in-situ surveying of NEAs
JF  - Acta Astronautica
Y1  - 2019
U6  - https://doi.org/10.1016/j.actaastro.2018.03.019
SN  - 0094-5765
VL  - 156
IS  - 3
SP  - 330
EP  - 362
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ketelhut, Maike
A1  - Kolditz, Melanie
A1  - Göll, Fabian
A1  - Braunstein, Bjoern
A1  - Albracht, Kirsten
A1  - Abel, Dirk
T1  - Admittance control of an industrial robot during resistance training
JF  - IFAC-PapersOnLine
N2  - Neuromuscular strength training of the leg extensor muscles plays an important role in the rehabilitation and prevention of age and wealth related diseases. In this paper, we focus on the design and implementation of a Cartesian admittance control scheme for isotonic training, i.e. leg extension and flexion against a predefined weight. For preliminary testing and validation of the designed algorithm an experimental research and development platform consisting of an 
industrial robot and a force plate mounted at its end-effector has been used. Linear, diagonal and arbitrary two-dimensional motion trajectories with different weights for the leg extension and flexion part are applied. The proposed algorithm is easily adaptable to trajectories consisting of arbitrary six-dimensional poses and allows the implementation of individualized trajectories.
KW  - Assistive technology
KW  - Rehabilitation engineering
KW  - Human-Computer interaction
KW  - Automatic control
Y1  - 2019
U6  - https://doi.org/10.1016/j.ifacol.2019.12.102
SN  - 2405-8963
N1  - 14th IFAC Symposium on Analysis, Design, and Evaluation of Human Machine Systems HMS 2019
Tallinn, Estonia, 16–91 September 2019
VL  - 52
IS  - 19
SP  - 223
EP  - 228
PB  - Elsevier
CY  - Amsterdam
ER  -