TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 5: Elektrochemie
Y1  - 2016
SN  - 978-3-662-47559-1
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 4: Reaktionskinetik
Y1  - 2016
SN  - 978-3-662-47674-1
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 3: Phasengleichgewichte
Y1  - 2016
SN  - 978-3-662-47571-3
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 2: Chemische Thermodynamik
Y1  - 2016
SN  - 978-3-662-47621-5
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 1: Grundlagen der Thermodynamik und Verhalten der Gase
Y1  - 2016
SN  - 978-3-662-47676-5
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Kowalczyk, Jürgen
T1  - Einführung in die Physik und Chemie der Grenzflächen und Kolloide
Y1  - 2016
SN  - 978-3-662-47018-3
U6  - https://doi.org/10.1007/978-3-662-47018-3
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Feuerriegel, Uwe
T1  - Verfahrenstechnik mit EXCEL: Verfahrenstechnische Berechnungen effektiv durchführen und professionell dokumentieren
Y1  - 2016
SN  - 978-3-658-02902-9
U6  - https://doi.org/10.1007/978-3-658-02903-6
N1  - 152 Abbildungen, 94 Abbildungen in Farbe

Gedruckt in der Bibliothek unter der Signatur: 21 ZNK 11
PB  - Springer Fachmedien
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Wilson, Ian D.
T1  - A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity
JF  - Drug Discovery Today
N2  - Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug–drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.
Y1  - 2016
U6  - https://doi.org/10.1016/j.drudis.2015.09.002
SN  - 1359-6446
VL  - 21
IS  - 2
SP  - 250
EP  - 263
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Scheer, Nico
A1  - Chu, Xiaoyan
A1  - Salphati, Laurent
A1  - Zamek-Gliszczynski, Maciej J.
ED  - Nicholls, Glynis
T1  - Knockout and humanized animal models to study membrane transporters in drug development
T2  - Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development
Y1  - 2016
SN  - 978-1-78262-379-3
U6  - https://doi.org/10.1039/9781782623793-00298
SP  - 298
EP  - 332
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Lengkeek, Nigel A.
A1  - Le, Van So
A1  - Pellegrini, Paul A.
A1  - Greguric, Ivan
A1  - Weiner, Ron
T1  - The role of additives in moderating the influence of Fe(III) and Cu(II) on the radiochemical yield of [⁶⁸Ga(DOTATATE)]
JF  - Applied Radiation and Isotopes
N2  - [⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3.
Y1  - 2016
U6  - https://doi.org/10.1016/j.apradiso.2015.09.008
SN  - 1872-9800
VL  - 107
SP  - 13
EP  - 16
PB  - Elsevier
CY  - Amsterdam
ER  -