TY - JOUR A1 - Röth, Anjali A. A1 - Slabu, Ioana A1 - Engelmann, Ulrich M. A1 - Baumann, Martin A1 - Schmitz-Rode, T. A1 - Neumann, U. P. T1 - Targeting von gastroenterologischen Tumoren mittels magnetischer Nanopartikel zur hyperthermischen Therapie JF - Zeitschrift für Gastroenterologie Y1 - 2017 U6 - https://doi.org/10.1055/s-0037-1605124 VL - 55 IS - 8 SP - KV-384 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Orzada, Stephan A1 - Bitz, Andreas A1 - Johst, Sören A1 - Gratz, Marcel A1 - Völker, Maximilian N. A1 - Kraff, Oliver A1 - Abuelhaija, Ashraf A1 - Fiedler, Thomas M. A1 - Solbach, Klaus A1 - Quick, Harald H. A1 - Ladd, Mark E. T1 - Analysis of an integrated 8-Channel Tx/Rx body array for use as a body coil in 7-Tesla MRI JF - Frontiers in Physics Y1 - 2017 U6 - https://doi.org/10.3389/fphy.2017.00017 SN - 2296-424X N1 - Article number 17 VL - 5 IS - Jun ER - TY - JOUR A1 - Bäcker, Matthias A1 - Koch, Claudia A1 - Eiben, Sabine A1 - Geiger, Fania A1 - Eber, Fabian A1 - Gliemann, Hartmut A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors JF - Sensors and Actuators B: Chemical N2 - The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips. Y1 - 2017 U6 - https://doi.org/10.1016/j.snb.2016.07.096 SN - 0925-4005 VL - 238 SP - 716 EP - 722 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schüller, K. A1 - Kowalski, Julia A1 - Raback, P. T1 - Curvilinear melting – A preliminary experimental and numerical study JF - International Journal of Heat and Mass Transfer N2 - When exploring glacier ice it is often necessary to take samples or implement sensors at a certain depth underneath the glacier surface. One way of doing this is by using heated melting probes. In their common form these devices experience a straight one-dimensional downwards motion and can be modeled by standard close-contact melting theory. A recently developed melting probe however, the IceMole, achieves maneuverability by simultaneously applying a surface temperature gradient to induce a change in melting direction and controlling the effective contact-force by means of an ice screw to stabilize its change in attitude. A modeling framework for forced curvilinear melting does not exist so far and will be the content of this paper. At first, we will extend the existing theory for quasi-stationary close-contact melting to curved trajectories. We do this by introducing a rotational mode. This additional unknown in the system implies yet the need for another model closure. Within this new framework we will focus on the effect of a variable contact-force as well as different surface temperature profiles. In order to solve for melting velocity and curvature of the melting path we present both an inverse solution strategy for the analytical model, and a more general finite element framework implemented into the open source software package ELMER. Model results are discussed and compared to experimental data conducted in laboratory tests. Y1 - 2016 U6 - https://doi.org/10.1016/j.ijheatmasstransfer.2015.09.046 SN - 0017-9310 IS - 92 SP - 884 EP - 892 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Arreola, Julio A1 - Mätzkow, Malte A1 - Durán, Marlena Palomar A1 - Greeff, Anton A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Optimization of the immobilization of bacterial spores on glass substrates with organosilanes JF - Physica status solidi (A) : Applications and materials science N2 - Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication. KW - silanization KW - organosilanes KW - immobilization KW - endospores KW - biosensors KW - Bacillus atrophaeus Y1 - 2016 U6 - https://doi.org/10.1002/pssa.201532914 SN - 1862-6319 VL - 213 IS - 6 SP - 1463 EP - 1470 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Hamad, E. M. A1 - Bilatto, S. E. R. A1 - Adly, N. Y. A1 - Correa, D. S. A1 - Wolfrum, B. A1 - Schöning, Michael Josef A1 - Offenhäusser, A. A1 - Yakushenko, A. T1 - Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices JF - Lab on a Chip N2 - Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing. Y1 - 2016 U6 - https://doi.org/10.1039/C5LC01195G SN - 1473-0189 VL - 16 IS - 1 SP - 70 EP - 74 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Fredebeul-Krein, Markus T1 - Warum staatliche Kaufprämien für Elektroautos abzulehnen sind JF - Wirtschaftliche Freiheit : das ordnungspolitische Journal N2 - Im Jahr 2015 wurden in Deutschland über drei Millionen Benzinautos und lediglich 12.363 Elektroautos neu zugelassen. Das ursprünglich von der Bundesregierung vorgegebene Ziel, dass bis 2020 eine Million E-Autos auf deutschen Straßen fahren (und bis 2030 sechs Millionen), rückt damit in immer weitere Ferne. Um das Ziel dennoch zu erreichen, plant die Bundesregierung nun eine staatli­che Prämie für den Kauf von Elektroautos: Umwelt-, Verkehrs- und Wirtschaftsministerium haben gemeinsam ein Konzept entworfen, dem zufolge private Käufer zukünftig einen Zuschuss von 5.000 Euro beim Erwerb eines Elektroautos bekommen sollen. 40 Prozent dieses Zuschusses soll von den Autoherstellern getragen werden. Das Programm, das weitere ausgabenwirksame öffentli­che Maßnahmen vorsieht, würde Kosten in Milliarden­höhe verursachen. Die beabsichtigte Subventionierung wirft die Frage auf, ob diese wirtschaftlich sinnvoll sind. Y1 - 2016 N1 - Hinweis: Dieser Text ist zugleich als Ausgabe Nr. 04/2016 der Reihe Ordnungspolitischer Kommentar des Instituts für Wirtschaftspolitik an der Universität zu Köln und des Otto-Wolff-Instituts für Wirtschaftsordnung erschienen. VL - 2016 IS - 4 PB - Alexander B. Brunner CY - Würzburg ER - TY - JOUR A1 - Bayon, Arnau A1 - Valero, Daniel A1 - Garcia-Bartual, Rafael A1 - Vallés-Morán, Francisco José A1 - López-Jiménez, P. Amparo T1 - Performance assessment of OpenFOAM and FLOW-3D in the numerical modeling of a low Reynolds number hydraulic jump JF - Environmental Modelling & Software N2 - A comparative performance analysis of the CFD platforms OpenFOAM and FLOW-3D is presented, focusing on a 3D swirling turbulent flow: a steady hydraulic jump at low Reynolds number. Turbulence is treated using RANS approach RNG k-ε. A Volume Of Fluid (VOF) method is used to track the air–water interface, consequently aeration is modeled using an Eulerian–Eulerian approach. Structured meshes of cubic elements are used to discretize the channel geometry. The numerical model accuracy is assessed comparing representative hydraulic jump variables (sequent depth ratio, roller length, mean velocity profiles, velocity decay or free surface profile) to experimental data. The model results are also compared to previous studies to broaden the result validation. Both codes reproduced the phenomenon under study concurring with experimental data, although special care must be taken when swirling flows occur. Both models can be used to reproduce the hydraulic performance of energy dissipation structures at low Reynolds numbers. Y1 - 2016 SN - 1364-8152 U6 - https://doi.org/10.1016/j.envsoft.2016.02.018 VL - 80 SP - 322 EP - 335 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Yu, Bing A1 - Isoda, Hiroko A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Visualization of the recovery process of defects in a cultured cell layer by chemical imaging sensor JF - Sensors and Actuators B: Chemical N2 - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) in the sample. In this study, a novel cell assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the recovery of defects in a cell layer brought into proximity of the sensing surface. A reduced impedance at a defect formed artificially in a cell layer was successfully visualized in a photocurrent image. The cell layer was cultured over two weeks, during which the temporal change of the photocurrent distribution corresponding to the recovery of the defect was observed. Y1 - 2016 U6 - https://doi.org/10.1016/j.snb.2016.04.018 SN - 0925-4005 VL - 236 SP - 965 EP - 969 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dantism, Shahriar A1 - Takenaga, Shoko A1 - Wagner, Patrick A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system JF - Physica status solidi (a) N2 - On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable “down times” during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements. Y1 - 2016 U6 - https://doi.org/10.1002/pssa.201533043 SN - 1862-6300 VL - 213 IS - 6 SP - 1479 EP - 1485 PB - Wiley-VCH CY - Weinheim ER -