TY - JOUR A1 - Horbach, Andreas A1 - Staat, Manfred T1 - Optical strain measurement for the modeling of surgical meshes and their porosity JF - Current Directions in Biomedical Engineering N2 - The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes. Y1 - 2018 U6 - https://doi.org/10.1515/cdbme-2018-0045 SN - 2364-5504 VL - Band 4 IS - 1 SP - 181 EP - 184 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Aboulnaga, Elhussiny A. A1 - Zou, Huibin A1 - Selmer, Thorsten A1 - Xian, Mo T1 - Development of a plasmid-based, tunable, tolC-derived expression system for application in Cupriavidus necator H16 JF - Journal of Biotechnology N2 - Cupriavidus necator H16 gains increasing attention in microbial research and biotechnological application due to its diverse metabolic features. Here we present a tightly controlled gene expression system for C. necator including the pBBR1-vector that contains hybrid promoters originating from C. necator native tolC-promoter in combination with a synthetic tetO-operator. The expression of the reporter gene from these plasmids relies on the addition of the exogenous inducer doxycycline (dc). The novel expression system offers a combination of advantageous features as; (i) high and dose-dependent recombinant protein production, (ii) tight control with a high dynamic range (On/Off ratio), which makes it applicable for harmful pathways or for toxic protein production, (iii) comparable cheap inducer (doxycycline, dc), (iv) effective at low inducer concentration, that makes it useful for large scale application, (v) rapid, diffusion controlled induction, and (vi) the inducer does not interfere within the cell metabolism. As applications of the expression system in C. necator H16, the growth ability on glycerol was enhanced by constitutively expressing the E. coli glpk gene-encoding for glycerol kinase. Likewise, we used the system to overcome the expression toxicity of mevalonate pathway in C. necator H16. With this system, the mevalonate-genes were successfully introduced in the host and the recombinant strains could produce about 200 mg/l mevalonate. Y1 - 2018 U6 - https://doi.org/10.1016/j.jbiotec.2018.03.007 SN - 0168-1656 VL - 274 SP - 15 EP - 27 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Stapenhorst, Carolin A1 - Zabek, Magdalena A1 - Hildebrand, Linda T1 - Communication process and information flow in the architectural planning context JF - Creativity game : theory and practice of spatial planning N2 - Against the background of growing data in everyday life, data processing tools become more powerful to deal with the increasing complexity in building design. The architectural planning process is offered a variety of new instruments to design, plan and communicate planning decisions. Ideally the access to information serves to secure and document the quality of the building and in the worst case, the increased data absorbs time by collection and processing without any benefit for the building and its user. Process models can illustrate the impact of information on the design- and planning process so that architect and planner can steer the process. This paper provides historic and contemporary models to visualize the architectural planning process and introduces means to describe today’s situation consisting of stakeholders, events and instruments. It explains conceptions during Renaissance in contrast to models used in the second half of the 20th century. Contemporary models are discussed regarding their value against the background of increasing computation in the building process. KW - Planning process KW - Manifestations KW - Tools KW - Conditions KW - Actors KW - Structure and Stages KW - Design process Y1 - 2018 U6 - https://doi.org/10.15292/IU-CG.2018.06.066-073 IS - 6 SP - 66 EP - 73 PB - University of Ljubljana CY - Ljubljana ER - TY - JOUR A1 - Stapenhorst, Carolin A1 - Motta, Luciano T1 - Città Olivettiana in Ivrea, Italien JF - Bauwelt Y1 - 2018 SN - 0005-6855 VL - 109 IS - 22 SP - 20 EP - 31 PB - Bauverlag BV CY - Gütersloh ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel T1 - Efficiency comparison of the Wilcoxon tests in paired and independent survey samples JF - Metrika N2 - The efficiency concepts of Bahadur and Pitman are used to compare the Wilcoxon tests in paired and independent survey samples. A comparison through the length of corresponding confidence intervals is also done. Simple conditions characterizing the dominance of a procedure are derived. Statistical tests for checking these conditions are suggested and discussed. KW - Wilcoxon tests KW - Pitman efficiency KW - Bahadur efficiency KW - Length of confidence intervals KW - Kernel density estimator Y1 - 2018 U6 - https://doi.org/10.1007/s00184-018-0661-4 SN - 1435-926X VL - 2018 IS - 81 SP - 891 EP - 930 PB - Springer CY - Berlin ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel A1 - Thiele, Jan Philipp T1 - Statistical inference for L²-distances to uniformity JF - Computational Statistics N2 - The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study. KW - Integrated empirical distribution (survival) function KW - Goodness-of-fit tests for uniformity KW - Numerical inversion of Laplace transforms KW - Coverage probability KW - Equivalence test Y1 - 2018 U6 - https://doi.org/10.1007/s00180-018-0820-0 SN - 1613-9658 VL - 2018 IS - 33 SP - 1863 EP - 1896 PB - Springer CY - Berlin ER - TY - JOUR A1 - Ditzhaus, Marc A1 - Gaigall, Daniel T1 - A consistent goodness-of-fit test for huge dimensional and functional data JF - Journal of Nonparametric Statistics N2 - A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cramér-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals. KW - Cramér-von-Mises statistic KW - separable Hilbert space KW - huge dimensional data KW - functional data Y1 - 2018 U6 - https://doi.org/10.1080/10485252.2018.1486402 SN - 1029-0311 VL - 30 IS - 4 SP - 834 EP - 859 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Harris, Isaac A1 - Kleefeld, Andreas T1 - The inverse scattering problem for a conductive boundary condition and transmission eigenvalues JF - Applicable Analysis N2 - In this paper, we consider the inverse scattering problem associated with an inhomogeneous media with a conductive boundary. In particular, we are interested in two problems that arise from this inverse problem: the inverse conductivity problem and the corresponding interior transmission eigenvalue problem. The inverse conductivity problem is to recover the conductive boundary parameter from the measured scattering data. We prove that the measured scatted data uniquely determine the conductivity parameter as well as describe a direct algorithm to recover the conductivity. The interior transmission eigenvalue problem is an eigenvalue problem associated with the inverse scattering of such materials. We investigate the convergence of the eigenvalues as the conductivity parameter tends to zero as well as prove existence and discreteness for the case of an absorbing media. Lastly, several numerical and analytical results support the theory and we show that the inside–outside duality method can be used to reconstruct the interior conductive eigenvalues. KW - Transmission eigenvalues KW - Conductive boundary condition KW - Inverse scattering Y1 - 2018 U6 - https://doi.org/10.1080/00036811.2018.1504028 SN - 1563-504X VL - 99 IS - 3 SP - 508 EP - 529 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Babilon, Katharina A1 - Wilbring, Daniela A1 - Tappert, Tim A1 - Pfaff, Raphael A1 - Enning, Manfred T1 - Schienenfahrzeugtechnik hands on – FH Aachen IMechE Railway Challenge JF - Ingenieurspiegel Y1 - 2018 SN - 1868-5919 IS - 2 SP - 20 EP - 22 PB - Public Verlag CY - Bingen ER - TY - JOUR A1 - Schmidt, Bernd A1 - Enning, Manfred A1 - Pfaff, Raphael T1 - Güterwagen 4.0 – Der Güterwagen für das Internet der Dinge Teil 3: Einführungsszenarien für aktive, kommunikative Güterwagen JF - ETR - Eisenbahntechnische Rundschau N2 - Wenn durch innovative, automatisierte Güterwagen betriebswirtschaftliche Vorteile nutzbar gemacht werden sollen, muss die Migration auf das neue System in sinnvollen Teilschritten unter Berücksichtigung der organisationellen und betrieblichen Vereinbarkeit vorgenommen werden. Eine stufenweise Migration mit Nachrüstbarkeit und Kompatibilität kann die optimale Ausstattungsvariante für die unterschiedlichen Betriebsszenarien sowie eine Steigerung der Wirtschaftlichkeit des Gesamtsystems bieten. Y1 - 2018 SN - 0013-2845 VL - 67 IS - 5 SP - 60 EP - 64 PB - DVV Media Group CY - Hamburg ER -