TY  - CHAP
A1  - Damm, Sebastian
A1  - Ritz, Thomas
A1  - Strauch, Jakob
T1  - Adaption of archetype patterns for mobile cloud-based business apps
T2  - 2011 IEEE International Conference on Pervasive Computing and Communications workshops (PerCom workshops 2011) : Seattle, Washington, USA, 21 - 25 March 2011
Y1  - 2011
SN  - 978-1-61284-938-6 (Print)
SN  - 978-1-61284-936-2 (E-Book)
U6  - http://dx.doi.org/10.1109/PERCOMW.2011.5766849
SP  - 100
EP  - 105
PB  - IEEE Service Center
CY  - Piscataway, NJ
ER  - 
TY  - CHAP
A1  - Fuchs, Britta
A1  - Ritz, Thomas
A1  - Halbach, Bastian
A1  - Hartl, Florian
ED  - Marca, David A.
T1  - Blended shopping : interactivity and individualization
T2  - Proceedings of the International Conference on e-Business : Seville, Spain, 18 - 21 July 2011 ; [... integrated in the ICETE (International Conference on e-Business and Telecommunications) joint conference]
Y1  - 2011
SN  - 978-989-8425-70-6
SP  - 47
EP  - 52
PB  - SciTePress
CY  - [Lissabon]
ER  - 
TY  - CHAP
A1  - Kirchhof, Michael
A1  - Kraft, Bodo
T1  - Dogmatisches „Entweder agil oder klassisch" im Projektmanagement hat ausgedient - die richtige Mischung macht's
T2  - Projekt-Sternstunden : strahlende Erfolge durch Kompetenz
Y1  - 2011
SN  - 978-3-924841-60-7
N1  - PM-Forum <28, 2011, Nürnberg> ; 
PM-Forum 2011, 28. Internationales Deutsches Projektmanagement-Forum ; Nürnberg, 25. - 26.10.2011 ; Tagungsband
SP  - 414
EP  - 425
PB  - GPM
CY  - Nürnberg
ER  - 
TY  - JOUR
A1  - Siers, Carsten
A1  - Sögtrop, Christian
A1  - Borrmann, Arne
A1  - Hoepner, Gert
T1  - Vernetzung von Kultur und Struktur
JF  - Sales-Business : der Navigator für Vertrieb, Verkauf und Strategie
Y1  - 2011
U6  - http://dx.doi.org/10.1365/s35141-011-0093-5
SN  - 1616-7902
VL  - 20
IS  - 5
SP  - 32
EP  - 34
PB  - Springer Gabler
CY  - Wiesbaden
ER  - 
TY  - CHAP
A1  - Buda, Aurel
A1  - Wollert, Jörg
T1  - Leistungsbewertung von Ultra Wideband Funktechnologien nach ECMA 368 für den Einsatz in industriellen Kommunikationssystemen
T2  - Kommunikation in der Automation : Magdeburg, 27. - 28.09.2011 ; 2. Jahreskolloquium Kommunikation in der Automation ; KOMMA 2011 / Ulrich Jumar ... (Hrsg.)
Y1  - 2011
SN  - 978-3-940961-58-7
PB  - ifak, Institut für Automation und Kommunikation e.V. Magdeburg an der Otto-von-Guericke-Universität Magdeburg
CY  - Magdeburg
ER  - 
TY  - CHAP
A1  - Stieglitz, Kristian
A1  - Wollert, Jörg
T1  - Approach of using ultra-wideband-radio in industrial real-time ethernet networks
T2  - The 4th International Multi-Conference on Engineering and Technological Innovation : IMETI : July 19th - July 22nd, 2011, Orlando, Florida, USA
Y1  - 2011
SP  - 1
EP  - 6
ER  - 
TY  - JOUR
A1  - Fuchs, Britta
A1  - Ritz, Thomas
T1  - Absatzkanäle kaum verknüpft
JF  - IT-Mittelstand : IT-Business im Mittelstand
Y1  - 2011
VL  - 2011
IS  - 9
SP  - 16
PB  - Medienhaus-Verlag
CY  - Bergisch-Gladbach
ER  - 
TY  - JOUR
A1  - Raab, Monika
A1  - Kappel, Sven
A1  - Krämer, Andrea
A1  - Sanhaji, Mourad
A1  - Matthess, Yves
A1  - Kurunci-Csacsko, Elisabeth
A1  - Calzada-Wack, Julia
A1  - Rathkolb, Birgit
A1  - Rosman, Jan
A1  - Adler, Thure
A1  - Busch, Dirk H.
A1  - Esposito, Irene
A1  - Fuchs, Helmut
A1  - Gailus-Durner, Valérie
A1  - Klingenspor, Martin
A1  - Wolf, Eckhard
A1  - Sänger, Nicole
A1  - Prinz, Florian
A1  - Hrabe de Angelis, Martin
A1  - Seibler, Jost
A1  - Yuan, Juping
A1  - Bergmann, Martin
A1  - Knecht, Rainald
A1  - Kreft, Bertolt
A1  - Strebhardt, Klaus
T1  - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
JF  - Nature Communications
Y1  - 2011
U6  - http://dx.doi.org/10.1038/ncomms1395
SN  - 2041-1723
VL  - 2
IS  - 395
SP  - 1
EP  - 11
PB  - Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Hasegawa, Maki
A1  - Kapelyukh, Yury
A1  - Tahara, Harunobu
A1  - Seibler, Jost
A1  - Rode, Anja
A1  - Krueger, Sylvia
A1  - Lee, Dongtao N.
A1  - Wolf, C. Roland
A1  - Scheer, Nico
T1  - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
JF  - Molecular Pharmacology
Y1  - 2011
U6  - http://dx.doi.org/10.1124/mol.111.071845
SN  - 1521-0111
VL  - 80
IS  - 33
SP  - 518
EP  - 528
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - http://dx.doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  -