TY - JOUR A1 - Miyamoto, K. A1 - Seki, K. A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Enhancement of the spatial resolution of the chemical imaging sensor by a hybrid fiber-optic illumination JF - Procedia Engineering N2 - The chemical imaging sensor, which is based on the principle of the light-addressable potentiometric sensor (LAPS), is a powerful tool to visualize the spatial distribution of chemical species on the sensor surface. The spatial resolution of this sensor depends on the diffusion of photocarriers excited by a modulated light. In this study, a novel hybrid fiber-optic illumination was developed to enhance the spatial resolution. It consists of a modulated light probe to generate a photocurrent signal and a ring of constant light, which suppresses the lateral diffusion of minority carriers excited by the modulated light. It is demonstrated that the spatial resolution was improved from 92 μm to 68 μm. Y1 - 2014 U6 - https://doi.org/10.1016/j.proeng.2014.11.563 SN - 1877-7058 N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014> VL - 87 SP - 612 EP - 615 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Almajhdi, Fahad N. A1 - Senger, Tilo A1 - Amer, Haitham M. A1 - Gissmann, Lutz A1 - Öhlschläger, Peter T1 - Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling) JF - PLOS one N2 - Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism. Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0113461 SN - 1932-6203 VL - 11 IS - 9 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Wollert, Jörg T1 - Funkstandards für Sensornetzwerke JF - Elektronik : Fachmedium für industrielle Anwender und Entwickler Y1 - 2014 SN - 0013-5658 VL - Bd. 63 IS - H. 12 SP - 36 EP - 41 PB - WEKA-Fachmedien CY - Haar ER - TY - JOUR A1 - Wollert, Jörg T1 - Echtzeit-Ethernet : Protokoll-Reigen JF - Elektronik : Fachmedium für industrielle Anwender und Entwickler Y1 - 2014 SN - 0013-5658 VL - Bd. 63 IS - H. 26 SP - 24 EP - 31 PB - WEKA-Fachmedien CY - Haar ER - TY - JOUR A1 - Wollert, Jörg T1 - Der Embedded Wireless-Report JF - Elektronik : Fachmedium für industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium für Entwicklungen funkbasierter Systeme Y1 - 2014 SN - 0013-5658 SP - 18 EP - 25 PB - WEKA-Fachmedien CY - Haar ER - TY - JOUR A1 - Wollert, Jörg T1 - Echtzeit-Ethernet mit Standardtechnik JF - Elektronik : Fachmedium für industrielle Anwender und Entwickler ; Sonderh. Embedded : Fachmagazin für die Entwicklung von Embedded-Systemen Y1 - 2014 SN - 0013-5658 VL - Bd. 63 IS - H. 12 SP - 28 EP - 32 PB - WEKA-Fachmedien CY - Haar ER - TY - JOUR A1 - Wollert, Jörg T1 - Feldbustechnologie JF - Factory : der Durchblick in der Technik Y1 - 2014 SP - Publ. online PB - WEKA-Industriemedien CY - Wien ER - TY - JOUR A1 - Demny, Andreas A1 - Hebel, Christoph T1 - Rechnergestützte Ermittlung der Verbindungsfunktionsstufen und der verbindungsbezogenen Angebotsqualität nach den Richtlinien für integrierte Netzgestaltung nach RIN 2008 JF - Straßenverkehrstechnik : Organ der Forschungsgesellschaft für Straßen- und Verkehrswesen, der Bundesvereinigung der Straßenbau- und Verkehrsingenieure und der Österreichischen Forschungsgesellschaft Straße und Verkehr ; Zeitschrift für Verkehrsplanung, Verkehrsmanagement, Verkehrssicherheit, Verkehrstechnik Y1 - 2014 SN - 0039-2219 VL - Jg. 58 IS - H. 12 SP - 811 EP - 820 PB - Kirschbaum Verlag CY - Bonn ER - TY - JOUR A1 - Thomas, Axel T1 - Generation Y JF - P.T. : Magazin für Wirtschaft und Gesellschaft Y1 - 2014 SN - 1860-501X VL - 10 IS - 3 SP - 6 EP - 9 PB - OPS Netzwerk CY - Leipzig ER - TY - JOUR A1 - Thomas, Axel A1 - Wassenberg, Gerd T1 - Erfolgreich sein im Kampf um die besten Talente : Employer Branding JF - Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen Y1 - 2014 N1 - Nur noch nach Anfrage bei der IHK Aachen erhältlich: https://www.ihk.de/aachen/servicemarken/presse/medien-der-ihk/wirtschaftliche-nachrichten/aktuelle-ausgaben PB - IHK Aachen CY - Aachen ER -