TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Lengkeek, Nigel A.
A1  - Le, Van So
A1  - Pellegrini, Paul A.
A1  - Greguric, Ivan
A1  - Weiner, Ron
T1  - The role of additives in moderating the influence of Fe(III) and Cu(II) on the radiochemical yield of [⁶⁸Ga(DOTATATE)]
JF  - Applied Radiation and Isotopes
N2  - [⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.apradiso.2015.09.008
SN  - 1872-9800
VL  - 107
SP  - 13
EP  - 16
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Hoehr, Cornelia
A1  - Hou, Xinchi
A1  - Hanemaayer, Victoire
A1  - Zeisler, Stefan
A1  - Adam, Michael J.
A1  - Ruth, Thomas J.
A1  - Celler, Anna
A1  - Buckley, Ken
A1  - Benard, Francois
A1  - Schaffer, Paul
T1  - Production of Y-86 and other radiometals for research purposes using a solution target system
JF  - Nuclear medicine and biology
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.nucmedbio.2015.06.005
SN  - 1872-9614
VL  - 42
IS  - 11
SP  - 842
EP  - 849
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hoehr, Cornelia
A1  - Paulßen, Elisabeth
A1  - Benard, Francois
A1  - Lee, Chris Jaeil
A1  - Hou, Xinchi
A1  - Badesso, Brian
A1  - Ferguson, Simon
A1  - Miao, Qing
A1  - Yang, Hua
A1  - Buckley, Ken
A1  - Hanemaayer, Victoire
A1  - Zeisler, Stefan
A1  - Ruth, Thomas
A1  - Celler, Anna
A1  - Schaffer, Paul
T1  - ⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron
JF  - Nuclear medicine and biology
N2  - Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.nucmedbio.2013.12.016
SN  - 1872-9614
VL  - 41
IS  - 5
SP  - 401
EP  - 406
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Infantino, Angelo
A1  - Paulßen, Elisabeth
A1  - Mostacci, Domiziano
A1  - Schaffer, Paul
A1  - Trinczek, Michael
A1  - Hoehr, Cornelia
T1  - Assessment of the production of medical isotopes using the Monte Carlo code FLUKA: Simulations against experimental measurements
JF  - Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
N2  - The Monte Carlo code FLUKA is used to simulate the production of a number of positron emitting radionuclides, ¹⁸F, ¹³N, ⁹⁴Tc, ⁴⁴Sc, ⁶⁸Ga, ⁸⁶Y, ⁸⁹Zr, ⁵²Mn, ⁶¹Cu and ⁵⁵Co, on a small medical cyclotron with a proton beam energy of 13 MeV. Experimental data collected at the TR13 cyclotron at TRIUMF agree within a factor of 0.6 ± 0.4 with the directly simulated data, except for the production of ⁵⁵Co, where the simulation underestimates the experiment by a factor of 3.4 ± 0.4. The experimental data also agree within a factor of 0.8 ± 0.6 with the convolution of simulated proton fluence and cross sections from literature. Overall, this confirms the applicability of FLUKA to simulate radionuclide production at 13 MeV proton beam energy.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.nimb.2015.10.067
SN  - 1872-9584
VL  - 366
SP  - 117
EP  - 123
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Liu, Z.
A1  - Schaap, K. S.
A1  - Ballemans, L.
A1  - de Blois, E.
A1  - Rohde, M.
A1  - Paulßen, Elisabeth
T1  - Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system
JF  - Dalton Transactions
Y1  - 2017
U6  - http://dx.doi.org/10.1039/C7DT01830D
SN  - 1477-9234
VL  - 46
IS  - 42
SP  - 14669
EP  - 14676
ER  - 
TY  - CHAP
A1  - Al-Kaidy, H.
A1  - Ulber, R.
A1  - Tippkötter, Nils
T1  - A platform technology for the automated reaction control in magnetizable micro-fluidic droplets
T2  - Biomaterials - made in bioreactors : book of abstracts, May 26 - 28, 2014, Radisson Blu Park Hotel and Conference Dentre, Radebeul, Germany
Y1  - 2014
SP  - 21
EP  - 22
PB  - DECHEMA
CY  - Frankfurt am Main
ER  - 
TY  - CHAP
A1  - Tippkötter, Nils
A1  - Roikaew, W.
A1  - Ulber, R.
T1  - An automated pilot plant for the bioengineering processing of concentrated whey
T2  - European BioPerspectives : in cooperation with BIOTECHNICA 2008 : 7 - 9 October 2008 Hannover, Germany ; book of abstracts ; abstracts, poster programme
Y1  - 2008
SP  - 98
PB  - Dechema
CY  - Frankfurt am Main
ER  - 
TY  - CHAP
A1  - Tippkötter, Nils
A1  - Möhring, S.
A1  - Maurer, S.
A1  - Roth, J.
T1  - Dezentrale Vorbehandlung und Verarbeitung pflanzlicher Reststoffe für Bioraffinerien
T2  - Kurzfassungen der Vorträge nach Sessions : Frühjahrstagung der Biotechnologen 2013, 4. - 5. März 2013, Dechema-Haus, Frankfurt am Main
Y1  - 2013
SP  - 5
CY  - Frankfurt am Main
ER  - 
TY  - CHAP
A1  - Tippkötter, Nils
T1  - Biotechnologische Gewinnung von Wertstoffen aus Molke : BiobasedWorld - Innovation in food
T2  - Biotechnica 2013 : European biotechnology science & industry news
Y1  - 2013
VL  - 12
IS  - 9, special
SP  - 33
EP  - 50
ER  - 
TY  - CHAP
A1  - Tippkötter, Nils
A1  - Stückmann, H.
A1  - Winkelmann, G.
A1  - Noack, U.
A1  - Beutel, S.
A1  - Scheper, T.
A1  - Ulber, R.
T1  - Optimisation of antibody-labelling of gold colloids for their application in an immunchromatographic assay for microcystin-LR
T2  - European BioPerspectives : celebrating the 25th DECHEMA annual convention of biotechnologists ; 30 May - 1 June 2007, Cologne, Germany ; book of abstracts ; abstracts, poster programme
Y1  - 2007
SP  - 126
PB  - Dechema
CY  - Frankfurt am Main
ER  -