TY - JOUR A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Label-free sensing of biomolecules with field-effect devices for clinical applications JF - Electroanalysis N2 - Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers. Y1 - 2014 U6 - https://doi.org/10.1002/elan.201400073 SN - 1521-4109 (E-Journal); 1040-0397 (Print) VL - 26 IS - 6 SP - 1197 EP - 1213 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Göttsche, Joachim A1 - Tamme, Rainer A1 - Nunez, Thomas T1 - Speicherung für Hochtemperaturwärme / Rainer Tamme ; Joachim Göttsche ; Thomas Nunez JF - Wärme und Kälte - Energie aus Sonne und Erde : Jahrestagung des Forschungsverbunds Sonnenenergie in Kooperation mit der Landesinitiative Zukunftsenergie NRW / Stadermann, Gerd, Hrsg. Y1 - 2005 SP - 126 EP - 131 PB - Forschungsverbund Sonnenenergie CY - Berlin ER - TY - BOOK A1 - Laack, Walter van T1 - Eine bessere Geschichte unserer Welt / Bd. 3. Der Tod Y1 - 2002 SN - 978-3-8311-3581-3 PB - van Laack CY - Aachen ER - TY - BOOK A1 - Renckly, Sven A1 - Wählisch, Georg T1 - Technisches Zeichnen für Dummies Y1 - 2017 SN - 978-3-527-70966-3 PB - Wiley CY - Weinheim ER - TY - THES A1 - Eilert, Denny T1 - Massenwohnungsbau in Berlin : eine Publikation zur Architektur des Massenwohnungsbaus in Berlin N2 - Berlin. Eine Stadt, die immer weiter wächst und beinahe aus allen Nähten platzt. Doch das Problem ist kein neues, denn bereits seit den 1920er-Jahren ist der Wohnraummangel in Berlin ein bekanntes Thema und immer wieder mussten hierfür in den letzten 100 Jahren Lösungen gefunden werden. Diese Publikation dokumentiert einen Querschnitt der Massenwohnbauten in Berlin, welche seit dem ersten Weltkrieg und auch insbesondere nach der Teilung der Stadt für die Unterbringung großer Menschenmengen konzipiert und gebaut wurden. Das Buch klärt über die Entstehung der Viertel und Gebäude auf, enthält Interviews einiger Bewohner*innen und bietet zudem fotografisch einen Blick hinter die Fassaden. Das Ziel ist es, das Thema Massenwohnraum vorzustellen und durch die detaillierten Einblicke die damit verknüpften – meist negativen – Stigmata abzubauen. KW - Sozialer Wohnungsbau KW - Architektur KW - Editorial-Design KW - Typografie KW - Fotografie Y1 - 2023 PB - FH Aachen CY - Aachen ER - TY - CHAP A1 - Digel, Ilya A1 - Dachwald, Bernd A1 - Artmann, Gerhard A1 - Linder, Peter A1 - Funke, O. T1 - A concept of a probe for particle analysis and life detection in icy environments N2 - A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa’s ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live. KW - Sonde KW - Eisschicht KW - Autofluoreszenzverfahren KW - Lichtstreuungsbasierte Instrumente KW - autofluorescence-based detection system KW - light scattering analysis Y1 - 2009 ER - TY - JOUR A1 - Turdumamatov, Samat A1 - Belda, Aljoscha A1 - Heuermann, Holger T1 - Shaping a decoupled atmospheric pressure microwave plasma with antenna structures, Maxwell’s equations, and boundary conditions JF - IEEE Transactions on Plasma Science N2 - This article addresses the need for an innovative technique in plasma shaping, utilizing antenna structures, Maxwell’s laws, and boundary conditions within a shielded environment. The motivation lies in exploring a novel approach to efficiently generate high-energy density plasma with potential applications across various fields. Implemented in an E01 circular cavity resonator, the proposed method involves the use of an impedance and field matching device with a coaxial connector and a specially optimized monopole antenna. This setup feeds a low-loss cavity resonator, resulting in a high-energy density air plasma with a surface temperature exceeding 3500 o C, achieved with a minimal power input of 80 W. The argon plasma, resembling the shape of a simple monopole antenna with modeled complex dielectric values, offers a more energy-efficient alternative compared to traditional, power-intensive plasma shaping methods. Simulations using a commercial electromagnetic (EM) solver validate the design’s effectiveness, while experimental validation underscores the method’s feasibility and practical implementation. Analyzing various parameters in an argon atmosphere, including hot S -parameters and plasma beam images, the results demonstrate the successful application of this technique, suggesting its potential in coating, furnace technology, fusion, and spectroscopy applications. KW - 3-D printing KW - Furnace KW - Fusion KW - Hot S-parameter KW - Mode converter Y1 - 2024 U6 - https://doi.org/10.1109/TPS.2024.3383589 SN - 0093-3813 (Print) SN - 1939-9375 (Online) IS - Early Access SP - 1 EP - 9 PB - IEEE ER - TY - CHAP A1 - Hoffschmidt, Bernhard A1 - Alexopoulos, Spiros A1 - Rau, Christoph A1 - Sattler, Johannes Christoph A1 - Anthrakidis, Anette A1 - Teixeira Boura, Cristiano José A1 - O’Connor, B. A1 - Chico Caminos, Ricardo Alexander A1 - Rendón, C. A1 - Hilger, P. T1 - Concentrating Solar Power T2 - Earth systems and environmental sciences N2 - The focus of this chapter is the production of power and the use of the heat produced from concentrated solar thermal power (CSP) systems. The chapter starts with the general theoretical principles of concentrating systems including the description of the concentration ratio, the energy and mass balance. The power conversion systems is the main part where solar-only operation and the increase in operational hours. Solar-only operation include the use of steam turbines, gas turbines, organic Rankine cycles and solar dishes. The operational hours can be increased with hybridization and with storage. Another important topic is the cogeneration where solar cooling, desalination and of heat usage is described. Many examples of commercial CSP power plants as well as research facilities from the past as well as current installed and in operation are described in detail. The chapter closes with economic and environmental aspects and with the future potential of the development of CSP around the world. KW - Central receiver power plant KW - Concentrated systems KW - Concentrating solar power KW - Fresnel power plant KW - Gas turbine Y1 - 2021 SN - 978-0-12-409548-9 U6 - https://doi.org/10.1016/B978-0-12-819727-1.00089-3 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Frotscher, Ralf A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity. Y1 - 2018 SN - 978-981-10-7904-7 U6 - https://doi.org/10.1007/978-981-10-7904-7_10 SP - 233 EP - 250 PB - Springer CY - Singapore ER - TY - THES A1 - Mros, Christina T1 - Entwicklung eines Erscheinungsbildes sowie einer Kampagne für die Allianz Chronischer Seltener Erkrankungen N2 - Die Allianz Chronischer Seltener Erkrankungen (ACHSE) ist das einzige krankheitsübergreifende Netzwerk von und für Menschen mit einer seltenen Erkrankung in Deutschland. Insgesamt sind 4 Millionen Menschen in Deutschland von einer der rund 8.000 seltenen Krankheiten betroffen. Durch die Seltenheit der verschiedenen Krankheiten ist es oft schwer, Experten zu finden, die richtige Versorgung sicherzustellen oder Studien durchzuführen. Betroffene fühlen sich oft nicht wahrgenommen und alleine gelassen. Die ACHSE dient als unabhängige Schnittstelle und Knotenpunkt zwischen Betroffenen, Regierung, Politik und Wirtschaft. Gemeinsam bündeln sich hier 130 Patientenorganisationen unter einem Dach, um die Betroffenen in den Fokus zu rücken. Ziel der Bachelorarbeit ist die Entwicklung eines Erscheinungsbildes sowie einer Kampagne, die das Thema mehr ins Bewusstsein der Öffentlichkeit bringt und informiert. KW - Pro bono KW - Corporate Design KW - Redesign KW - Rare Diseases KW - Seltene Erkrankungen Y1 - 2021 N1 - Für diese Arbeit steht kein Volltext zur Verfügung. PB - FH Aachen CY - Aachen ER -