TY  - JOUR
A1  - Droop, Philipp
A1  - Chen, Shaohuang
A1  - Radford, Melissa J.
A1  - Paulßen, Elisabeth
A1  - Gates, Byron D.
A1  - Reilly, Raymond M.
A1  - Radchenko, Valery
A1  - Hoehr, Cornelia
T1  - Synthesis of 197m/gHg labelled gold nanoparticles for targeted radionuclide therapy
JF  - Radiochimica Acta
N2  - Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 h and 64.1 h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 μg (gold)/mL with an activity of 151 ± 93 kBq/mL (197gHg, time corrected to the end of bombardment).
KW  - 197m/gHg
KW  - Gold nanoparticle (AuNP)
KW  - Meitner-Auger-electron (MAE)
KW  - Targeted radionuclide therapy (TRT)
Y1  - 2023
U6  - https://doi.org/10.1515/ract-2023-0144
SN  - 2193-3405
VL  - 111
IS  - 10
SP  - 773
EP  - 779
PB  - De Gruyter
CY  - Berlin [u.a.]
ER  - 
TY  - CHAP
A1  - Bergmann, Kevin
A1  - Gräbener, Josefine
A1  - Wild, Dominik
A1  - Ulfers, H.
A1  - Czupalla, Markus
T1  - Study on thermal stabilization of a GEO-stationary telescope baffling system by integral application of phase change material
T2  - International Conference on Environmental Systems
N2  - The utilization of phase change material (PCM) for latent heat storage and thermal control of spacecraft has been demonstrated in the past in few missions only. One limiting factor was the fact that all concepts developed so far envisioned the PCM to be applied as an additional capacitor, encapsulated in its own housing, leading to mass, efficiency and accommodation challenges. Recently, the application of PCM within the scan cavity of a GEOS type satellite has been suggested, in order to tackle thermal issues due to direct sun intrusion (Choi, M., 2014). However, the application of PCM in such complex mechanical structures is extremely challenging. A new concept to tackle this issue is currently under development at the FH Aachen University of Applied Sciences. The concept "Infused Thermal Solutions (ITS)" is based on the idea to 3D print metallic structures in their regular functional shape, but double walled with internal lattice support structures, allowing the infusion of a PCM layer directly into the voids and eliminating the need for additional parts and interfaces. Together with OHB System, FH Aachen theoretically studied the application of this technology to the Meteosat Third Generation (MTG) Infra-Red Sounder (IRS) instrument. The study focuses on the scan cavity and entrance baffling assembly (EBA) of the IRS. It consists of thermal analyses, 3D-redesign and bread boarding of a scaled and PCM infused EBA version. In the thermal design of the alternative EBA, PCM was applied directly into the EBA, simulating the worst hot case sun intrusion of the mission. By applying 4kg of PCM (to a 60kg baffle) the EBA temperature excursions during sun intrusion were limited from 140K to 30K, leading to a significant thermo-opto-elastic performance gain. This paper introduces the ITS concept development status.
Y1  - 2019
N1  - 49th International Conference on Environmental Systems, 7-11 July 2019, Boston, Massachusetts ; ICES-2019-72
SP  - 1
EP  - 14
ER  - 
TY  - GEN
A1  - Gamgami, Farid
A1  - Czupalla, Markus
A1  - Garcia, Antonio
A1  - Agnolon, David
T1  - From planetary transits to spacecraft design: achieving PLATO’s pointing performance
T2  - A7. Symposium on technological Requirement for future space astronomy and solar-system science missions
N2  - In the last decades, several hundred exoplanets could be detected thanks to space-based observatories, namely CNES’ COROT and NASA’s Kepler. To expand this quest ESA plans to launch CHEOPS as the f irst small class mission in the cosmic visions program (S1) and PLATO as the 3rd medium class mission, so called M3 . PLATO’s primary objective is the detection of Earth like Exoplanets orbiting solar type stars in the habitable zone and characterisation of their bulk properties. This is possible by precise lightcurve measurement via 34 cameras. That said it becomes obvious that accurate pointing is key to achieve the required signal to noise ratio for positive transit detection. The paper will start with a comprehensive overview of PLATO’s mission objectives and mission architecture. Hereafter, special focus will be devoted to PLATO’s pointing requirements. Understanding the very nature of PLATO’s pointing requirements is essential to derive a design baseline to achieve the required performance. The PLATO frequency domain is of particular interest, ranging from 40 mHz to 3 Hz. Due to the very different time-scales involved, the spectral pointing requirement is decomposed into a high frequency part dominated by the attitude control system and the low frequency part dominated by the thermo-elastic properties of the spacecraft’s configuration. Both pose stringent constraints on the overall design as well as technology properties to comply with the derived requirements and thus assure a successful mission.
Y1  - 2016
N1  - 67th International Astronautical Congress, 26. - 30. September 2016, Guadalajara, Mexico
ER  - 
TY  - CHAP
A1  - Bung, Daniel Bernhard
A1  - Langohr, Phillip
A1  - Waldenberger, Lisa
ED  - Habersack, Helmut
ED  - Tritthart, Michael
T1  - Influence of cycle number in CFD studies of labyrinth weirs
T2  - Proceedings of the 40th IAHR World Congress (Vienna, 2023)
N2  - The major advantage of labyrinth weirs over linear weirs is hydraulic efficiency. In hydraulic modeling efforts, this strength contrasts with limited pump capacity as well as limited computational power for CFD simulations. For the latter, reducing the number of investigated cycles can significantly reduce necessary computational time. In this study, a labyrinth weir with different cycle numbers was investigated. The simulations were conducted in FLOW-3D HYDRO as a Large Eddy Simulation. With a mean deviation of 1.75 % between simulated discharge coefficients and literature design equations, a reasonable agreement was found. For downstream conditions, overall consistent results were observed as well. However, the orientation of labyrinth weirs with a single cycle should be chosen carefully under consideration of the individual research purpose.
KW  - CFD
KW  - Large Eddy Simulation
KW  - Labyfrinth weirs
Y1  - 2023
SN  - 978-90-833476-1-5
U6  - https://doi.org/10.3850/978-90-833476-1-5_iahr40wc-p0531-cd
SN  - L 2521-7119 (online)
N1  - Vienna, Austria, from August 21 to 25, 2023
PB  - International Association for Hydro-Environment Engineering and Research (IAHR)
CY  - Madrid
ER  - 
TY  - GEN
A1  - Eccleston, Paul
A1  - Drummond, Rachel
A1  - Middleton, Kevin
A1  - Bishop, Georgia
A1  - Caldwell, Andrew
A1  - Desjonqueres, Lucile
A1  - Tosh, Ian
A1  - Cann, Nick
A1  - Crook, Martin
A1  - Hills, Matthew
A1  - Pearson, Chris
A1  - Simpson, Caroline
A1  - Stamper, Richard
A1  - Tinetti, Giovanna
A1  - Pascale, Enzo
A1  - Swain, Mark
A1  - Holmes, Warren A.
A1  - Wong, Andre
A1  - Puig, Ludovic
A1  - Pilbratt, Göran
A1  - Linder, Martin
A1  - Boudin, Nathalie
A1  - Ertel, Hanno
A1  - Gambicorti, Lisa
A1  - Halain, Jean-Philippe
A1  - Pace, Emanuele
A1  - Vilardell, Francesc
A1  - Gómez, José M.
A1  - Colomé, Josep
A1  - Amiaux, Jérôme
A1  - Cara, Christophe
A1  - Berthe, Michel
A1  - Moreau, Vincent
A1  - Morgante, Gianluca
A1  - Malaguti, Giuseppe
A1  - Alonso, Gustavo
A1  - Álvarez, Javier P.
A1  - Ollivier, Marc
A1  - Philippon, Anne
A1  - Hellin, Marie-Laure
A1  - Roose, Steve
A1  - Frericks, Martin
A1  - Krijger, Matthijs
A1  - Rataj, Miroslaw
A1  - Wawer, Piotr
A1  - Skup, Konrad
A1  - Sobiecki, Mateusz
A1  - Christian Jessen, Niels
A1  - Møller Pedersen, Søren
A1  - Hargrave, Peter
A1  - Griffin, Matt
A1  - Ottensamer, Roland
A1  - Hunt, Thomas
A1  - Rust, Duncan
A1  - Saleh, Aymen
A1  - Winter, Berend
A1  - Focardi, Mauro
A1  - Da Deppo, Vania
A1  - Zuppella, Paola
A1  - Czupalla, Markus
ED  - Lystrup, Makenzie
ED  - Perrin, Marshall D.
ED  - Batalha, Natalie
ED  - Siegler, Nicholas
ED  - Tong, Edward C.
T1  - The ARIEL payload: A technical overview
T2  - Space Telescopes and Instrumentation 2020: Optical, Infrared, and Millimeter Wave
N2  - The Atmospheric Remote-Sensing Infrared Exoplanet Large-survey, ARIEL, has been selected to be the next (M4) medium class space mission in the ESA Cosmic Vision programme. From launch in 2028, and during the following 4 years of operation, ARIEL will perform precise spectroscopy of the atmospheres of ~1000 known transiting exoplanets using its metre-class telescope. A three-band photometer and three spectrometers cover the 0.5 µm to 7.8 µm region of the electromagnetic spectrum. This paper gives an overview of the mission payload, including the telescope assembly, the FGS (Fine Guidance System) - which provides both pointing information to the spacecraft and scientific photometry and low-resolution spectrometer data, the ARIEL InfraRed Spectrometer (AIRS), and other payload infrastructure such as the warm electronics, structures and cryogenic cooling systems.
KW  - Exoplanet
KW  - Spectroscopy
KW  - Transit
KW  - Atmospheres
KW  - Payload
Y1  - 2020
U6  - https://doi.org/10.1117/12.2561478
N1  - Space Telescopes and Instrumentation 2020: Optical, Infrared, and Millimeter Wave, 14–22 December 2020, Online Only, United States
VL  - 11443
SP  - 114430Z
PB  - SPIE
CY  - Washington
ER  - 
TY  - GEN
A1  - Graf, Alain-Michel
A1  - Steinhof, Rafael
A1  - Lotz, Martin
A1  - Tippkötter, Nils
A1  - Kasper, Cornelia
A1  - Beutel, Sascha
A1  - Ulber, Roland
T1  - Downstream-Processing mit Membranadsorbern zur Isolierung nativer Proteinfraktionen aus Kartoffelfruchtwasser
T2  - Chemie Ingenieur Technik
N2  - Bei der Stärkeproduktion entstehendes Kartoffelfruchtwasser besitzt mit 2 – 3 % einen hohen Anteil an ernährungsphysiologisch interessanten Proteinen. Die industrielle Gewinnung dieser Proteinfracht liefert jedoch lediglich ein minderwertiges, denaturiertes Produkt. Mit Hilfe der Membranadsorber-Technologie lassen sich aus Kartoffelfruchtwasser unter milden Reaktionsbedingungen native bioaktive Proteinfraktionen gewinnen. Geeignete Trennbedingungen wurden im Labormaßstab entwickelt und in den Technikumsmaßstab übertragen. An Anionenaustauscher-Membranadsorbern mit einer Membranfläche von 10 000 cm2 wurde eine Patatinhaltige Fraktion (44 kDa) mit Bindungskapazitäten von 0,37 mg/cm2 isoliert. Eine niedermolekulare Proteinfraktion mit Protease-Inhibitoren konnte durch Kationenaustauscher-Membranadsorber mit Bindungskapazitäten von 1,00 mg/cm2 gewonnen werden. Sie ist für verschiedenste Applikationen in der pharmazeutischen, kosmetischen und der Nahrungsmittelindustrie interessant z. B. für Appetitzügler oder muskelaufbauende Proteinpräparate. Der Aufreinigung der nativen Proteinfraktionen durch Ultra-/Diafiltration schließt sich die Konfektionierung durch Sprühtrocknung an. Die bioanalytische Charakterisierung der Produkte belegt die Reinheit und die enzymatische Aktivität sowie die Abreicherung von Störkomponenten wie Glykoalkaloide und Polyphenoloxidasen.
Y1  - 2009
U6  - https://doi.org/10.1002/cite.200800139
VL  - 81
IS  - 3
SP  - 267
EP  - 274
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - GEN
A1  - Reiswich, Martin
A1  - Brandt, Hannes
A1  - Czupalla, Markus
T1  - Passive thermal control by integration of phase change material into additively manufactured structures
T2  - E2. 47th Student conference
N2  - Optical Instruments require an extremely stable thermal surrounding to prevent loss of data quality by misalignments of the instrument components resulting from material deformation due to temperature f luctuations (e.g. from solar intrusion). Phase Change Material (PCM) can be applied as a thermal damper to achieve a more uniform temperature distribution. The challenge of this method is, among others, the integration of PCM into affected areas. If correctly designed, incoming heat is latently absorbed during phase change of the PCM, i.e. the temperature of a structure remains almost constant. In a cold phase, the heat during phase change is released again latently until the PCM returns to its original state of aggregation. Thus, the structure is thermally stabilized. At FH Aachen– University of Applied Sciences research is conducted to apply PCM directly into the structures of affected components (baffles, optical benches, electronic boxes, etc.). Through the application of Additive Manufacturing, the necessary voids are directly printed into these structures and filled later with PCM. Additive Manufacturing enables complex structures that would not have been possible with conservative manufacturing methods. A corresponding Breadboard was developed and manufactured by Selective Laser Melting (SLM). The current state of research includes the handling and analysis of the Breadboard, tests and a correlation of the thermal model. The results have shown analytically and practically that it is possible to use PCM as an integral part of the structure as a thermal damper. The results serve as a basis for the further development of the technology, which should maximize performance and enable the integration of PCM into much more complex structures.
Y1  - 2019
N1  - 70th International Astronautical Congress, 21. - 25. Oktober 2019, Washington D.C., United States
ER  - 
TY  - JOUR
A1  - Czupalla, Markus
T1  - Ein Garten im Weltraum
JF  - Spektrum der Wissenschaft
Y1  - 2017
PB  - Spektrum-der-Wiss.-Verl.-Ges.
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Saretzki, Charlotte
A1  - Bergmann, Ole
A1  - Dahmann, Peter
A1  - Janser, Frank
A1  - Keimer, Jona
A1  - Machado, Patricia
A1  - Morrison, Audry
A1  - Page, Henry
A1  - Pluta, Emil
A1  - Stübing, Felix
A1  - Küpper, Thomas
T1  - Are small airplanes safe with regards to COVID-19 transmission?
JF  - Journal of Travel Medicine
Y1  - 2021
U6  - https://doi.org/10.1093/jtm/taab105
SN  - 1708-8305
VL  - 28
IS  - 7
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - GEN
A1  - Mayntz, Joscha
A1  - Keimer, Jona
A1  - Tegtmeyer, Philipp
A1  - Dahmann, Peter
A1  - Hille, Sebastian
A1  - Stumpf, Eike
A1  - Fisher, Alex
A1  - Dorrington, Graham
T1  - Aerodynamic Investigation on Efficient Inflight Transition of a Propeller from Propulsion to Regeneration Mode
T2  - AIAA SCITECH 2022 Forum
N2  - This paper discusses a new way of inflight power regeneration for electric or hybrid-electric driven general aviation aircraft with one powertrain for both configurations. Three different approaches for the shift from propulsion to regeneration mode are analyzed. Numerical cal-culation and wind tunnel results are compared and show the highest regeneration potential for the "Windmill" approach, where the propeller blades are flipped, and rotation is reversed. A combination of all regeneration approaches for a realistic flight mission is discussed.
Y1  - 2021
U6  - https://doi.org/10.2514/6.2022-0546
N1  - AIAA SCITECH 2022 Forum, January 3-7, 2022, San Diego, CA & Virtual
PB  - AIAA
CY  - Reston, Va.
ER  -