TY - JOUR A1 - Siqueira, Jose R. A1 - Maki, Rafael M. A1 - Paulovich, Fernando V. A1 - Werner, Frederik A1 - Poghossian, Arshak A1 - Oliveira, Maria C. F. de A1 - Zucolotto, Valtencir A1 - Oliveira, Osvaldo N. Jr. A1 - Schöning, Michael Josef T1 - Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor JF - Analytical Chemistry (2010) Y1 - 2010 SN - 0003-2700 SP - 61 EP - 65 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, I. M. T1 - Mit Statistik gemeistert: perfekte Augentropfen und idealer Screeningtest : Möglichkeiten und Grenzen statistischer Methoden beim Glaukom JF - Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft N2 - Hintergrund Die Anwendung und das Verständnis von Statistik sind sehr wichtig für die biomedizinische Forschung und für die klinische Praxis. Dies gilt insbesondere auch zur Abschätzung der Möglichkeiten unterschiedlichster Diagnostik- und Therapieoptionen beim Glaukom. Die scheinbare Komplexität der Statistik, die zum Teil dem „gesunden Menschenverstand“ zu widersprechen scheint, zusammen mit der nur vorsichtigen Akzeptanz der Statistik bei vielen Medizinern können zu bewussten und unbewussten Manipulationen bei der Datendarstellung und -interpretation führen. Ziel der Arbeit Ziel ist die verständliche Darstellung einiger typischer Fehler in der medizinisch-statistischen Datenbehandlung. Material und Methoden Anhand hypothetischer Beispiele aus der Glaukomdiagnostik erfolgen die Darstellung der Wirkung eines hypotensiven Medikamentes sowie die Beurteilung der Ergebnisse eines diagnostischen Tests. Es werden die typischsten statistischen Einsatzbereiche und Irrtumsquellen ausführlich und verständlich analysiert Ergebnisse Mechanismen von Datenmanipulation und falscher Dateninterpretation werden aufgeklärt. Typische Irrtumsquellen bei der statistischen Auswertung und Datendarstellung werden dabei erläutert. Schlussfolgerungen Die erläuterten praktischen Beispiele zeigen die Notwendigkeit, die Grundlagen der Statistik zu verstehen und korrekt anwenden zu können. Fehlendes Grundlagenwissen und Halbwissen der medizinischen Statistik können zu folgenschweren Missverständnissen und falschen Entscheidungen in der medizinischen Forschung, aber auch in der klinischen Praxis führen. Y1 - 2016 U6 - https://doi.org/10.1007/s00347-016-0312-y SN - 0941-293X SN - 1433-0423 N1 - Englischer Titel: Mastered with statistics: perfect eye drops and ideal screening test : possibilities and limits of statistical methods for glaucoma IS - 113 SP - 838 EP - 843 PB - Springer CY - Berlin ER - TY - CHAP A1 - Hafner, David A1 - Ochs, Peter A1 - Weickert, Joachim A1 - Reißel, Martin ED - Rosenhahn, Bodo T1 - FSI Schemes : Fast Semi-Iterative Solvers for PDEs and Optimisation Methods T2 - Pattern Recognition : 38th German Conference, GCPR 2016, Hannover, Germany, September 12-15, 2016, Proceedings Y1 - 2016 SN - 978-3-319-45886-1 U6 - https://doi.org/10.1007/978-3-319-45886-1_8 N1 - Lecture Notes in Computer Science; Vol. 9796 SP - 91 EP - 102 PB - Springer ER - TY - JOUR A1 - Wagner, Torsten A1 - Vornholt, Wolfgang A1 - Werner, Frederik A1 - Yoshinobu, Tatsuo A1 - Miyamoto, Ko-Ichiro A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening JF - Physics in medicine N2 - The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution. Y1 - 2016 U6 - https://doi.org/10.1016/j.phmed.2016.03.001 SN - 2352-4510 VL - 2016 IS - 1 SP - 2 EP - 7 ER - TY - JOUR A1 - Doll, Theodor A1 - Wagner, Torsten A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Schöning (eds.) JF - Physica status solidi (a) Y1 - 2016 U6 - https://doi.org/10.1002/pssa.201670641 SN - 1862-6319 VL - 213 IS - 6 SP - 1393 EP - 1394 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Abel, Dirk A1 - Fasse, Alessandro A1 - Brüggemann, Gert-Peter A1 - Albracht, Kirsten T1 - Evaluation of foot position and orientation as manipulated variables to control external knee adduction moments in leg extension training JF - Computer methods and programs in biomedicine N2 - Background and Objective Effective leg extension training at a leg press requires high forces, which need to be controlled to avoid training-induced damage. In order to avoid high external knee adduction moments, which are one reason for unphysiological loadings on knee joint structures, both training movements and the whole reaction force vector need to be observed. In this study, the applicability of lateral and medial changes in foot orientation and position as possible manipulated variables to control external knee adduction moments is investigated. As secondary parameters both the medio-lateral position of the center of pressure and the frontal-plane orientation of the reaction force vector are analyzed. Methods Knee adduction moments are estimated using a dynamic model of the musculoskeletal system together with the measured reaction force vector and the motion of the subject by solving the inverse kinematic and dynamic problem. Six different foot conditions with varying positions and orientations of the foot in a static leg press are evaluated and compared to a neutral foot position. Results Both lateral and medial wedges under the foot and medial and lateral shifts of the foot can influence external knee adduction moments in the presented study with six healthy subjects. Different effects are observed with the varying conditions: the pose of the leg is changed and the direction and center of pressure of the reaction force vector is influenced. Each effect results in a different direction or center of pressure of the reaction force vector. Conclusions The results allow the conclusion that foot position and orientation can be used as manipulated variables in a control loop to actively control knee adduction moments in leg extension training. KW - External knee adduction moments KW - Manipulated variables KW - Inverse dynamic problem KW - Inverse kinematic problem KW - Musculoskeletal model Y1 - 2016 U6 - https://doi.org/10.1016/j.cmpb.2016.09.005 SN - 0169-2607 N1 - Part of special issue: "SI: Personalised Models and System Identification" VL - 171 SP - 81 EP - 86 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Belavy, Daniel L. A1 - Albracht, Kirsten A1 - Bruggemann, Gert-Peter A1 - Vergroesen, Pieter-Paul A. A1 - Dieen, Jaap H. van T1 - Can exercise positively influence the intervertebral disc? JF - Sports Medicine N2 - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research. KW - Intradiscal Pressure KW - Annulus Fibrosus KW - Disc Degeneration KW - Nucleus Pulposus KW - Intervertebral Disc Y1 - 2016 U6 - https://doi.org/10.1007/s40279-015-0444-2 SN - 1179-2035 VL - 46 IS - 4 SP - 473 EP - 485 PB - Springer CY - Berlin ER - TY - JOUR A1 - Seynnes, O. R. A1 - Bojsen-Moller, J. A1 - Albracht, Kirsten A1 - Arndt, A. A1 - Cronin, N. J. A1 - Finni, T. A1 - Magnusson, S. P. T1 - Ultrasound-based testing of tendon mechanical properties: a critical evaluation JF - Journal of Applied Physiology Y1 - 2015 U6 - https://doi.org/10.1152/japplphysiol.00849.2014 SN - 8750-7587 VL - 118 IS - 2 SP - 133 EP - 141 ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans JF - European Journal of Applied Physiology Y1 - 2013 U6 - https://doi.org/10.1007/s00421-012-2585-4 SN - 1439-6327 VL - 113 IS - 6 SP - 1605 EP - 1615 PB - Springer CY - Berlin ER - TY - JOUR A1 - Karamanidis, Kiros A1 - Albracht, Kirsten A1 - Braunstein, Bjoern A1 - Catala, Maria Moreno A1 - Goldmann, Jan-Peter A1 - Brüggemann, Gert-Peter T1 - Lower leg musculoskeletal geometry and sprint performance JF - Gait and Posture N2 - The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components. Y1 - 2011 U6 - https://doi.org/10.1016/j.gaitpost.2011.03.009 SN - 0966-6362 VL - 34 IS - 1 SP - 138 EP - 141 PB - Elsevier CY - Amsterdam ER -