TY  - JOUR
A1  - Scheer, Nico
A1  - Balimane, Praveen
A1  - Hayward, Michael D.
A1  - Buechel, Sandra
A1  - Kauselmann, Gunther
A1  - Wolf, C. Roland
T1  - Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
JF  - Drug Metabolism and Disposition
N2  - The multidrug resistance protein (MRP) 2 is predominantly expressed in liver, intestine, and kidney, where it plays an important role in the excretion of a range of drugs and their metabolites or endogenous compounds into bile, feces, and urine. Mrp knockout [Mrp2(−/−)] mice have been used recently to study the role of MRP2 in drug disposition. Here, we describe the first generation and initial characterization of a mouse line humanized for MRP2 (huMRP2), which is nulled for the mouse Mrp2 gene and expresses the human transporter in the organs and cell types where MRP2 is normally expressed. Analysis of the mRNA expression for selected cytochrome P450 and transporter genes revealed no major changes in huMRP2 mice compared with wild-type controls. We show that human MRP2 is able to compensate functionally for the loss of the mouse transporter as demonstrated by comparable bilirubin levels in the humanized mice and wild-type controls, in contrast to the hyperbilirubinemia phenotype that is observed in MRP2(−/−) mice. The huMRP2 mouse provides a model to study the role of the human transporter in drug disposition and in assessing the in vivo consequences of inhibiting this transporter by compounds interacting with human MRP2.
Y1  - 2012
U6  - https://doi.org/10.1124/dmd.112.047605
SN  - 1521-0111
VL  - 40
IS  - 11
SP  - 2212
EP  - 2218
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Gaigall, Daniel
T1  - On a new approach to the multi-sample goodness-of-fit problem
JF  - Communications in Statistics - Simulation and Computation
N2  - Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.
KW  - Goodness-of-fit test
KW  - Multi-sample problem
KW  - Parametric bootstrap
Y1  - 2019
U6  - https://doi.org/10.1080/03610918.2019.1618472
SN  - 1532-4141
VL  - 53
IS  - 10
SP  - 2971
EP  - 2989
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - CHAP
A1  - Lenz, Laura L.
A1  - Wolf, Martin R.
ED  - Kritz, Willy Christian
T1  - Economic evaluation of serious games with the comparative assessment framework COSEGA
T2  - The shift from teaching to learning : individual, collective and organizational learning through gaming simulation ; proceedings of the 45th conference of the International Simulation and Gaming Association, Dornbirn 2014
Y1  - 2014
SN  - 978-3-7639-5422-3
SP  - 374
EP  - 386
PB  - Bertelsmann
CY  - [Bielefeld]
ER  - 
TY  - JOUR
A1  - Kurz, Melanie
T1  - Images of Sweden in Germany: from Sundborn and Bullerby to Ikea
JF  - nomad: the magazine for new design culture, business affairs and contemporary lifestyle
Y1  - 2019
SN  - 2513-0714
IS  - 8
SP  - 136
EP  - 147
ER  - 
TY  - GEN
A1  - Gräßl, Andreas
A1  - Renz, Wolfgang
A1  - Hezel, Fabian
A1  - Frauenrath, Tobias
A1  - Pfeiffer, Harald
A1  - Hoffmann, Werner
A1  - Kellmann, Peter
A1  - Martin, Conrad
A1  - Niendorf, Thoralf
T1  - Design, evaluation and application of a modular 32 channel transmit/receive surface coil array for cardiac MRI at 7T
T2  - 2012 ISMRM Annual Meeting Proceedings
N2  - Cardiac MR (CMR) at ultrahigh (≥7.0 T) fields is regarded as one of the most challenging MRI applications. At 7.0 T image quality is not always exclusively defined by signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). Detrimental effects bear the potential to spoil the signal-to-noise (SNR) and contrast-to-noise (CNR) benefits of cardiac MR (CMR) at 7.0 T. B₁⁺-inhomogeneities and signal voids represent the main challenges. Various pioneering coil concepts have been proposed to tackle these issues, enabling cardiac MRI at 7.0 T. This includes a trend towards an ever larger number of transmit and receive channels.  This approach affords multi-dimensional B₁⁺ modulations to improve B₁⁺ shimming performance and to enhance RF efficiency. Also, parallel imaging benefits from a high number of receive channels enabling two-dimensional acceleration. Realizing the limitations of existing coil designs tailored for UHF CMR and recognizing the opportunities of a many element TX/RX channel architecture this work proposes a modular, two dimensional 32-channel transmit and receive array using loop elements and examines its efficacy for enhanced B¹+ homogeneity and improved parallel imaging performance.
Y1  - 2012
SN  - 1545-4428
N1  - ISMRM 20th Annual Meeting & Exhibition, 5-11 May 2012, Melbourne, Australia
ER  - 
TY  - JOUR
A1  - Schulte-Tigges, Joschua
A1  - Förster, Marco
A1  - Nikolovski, Gjorgji
A1  - Reke, Michael
A1  - Ferrein, Alexander
A1  - Kaszner, Daniel
A1  - Matheis, Dominik
A1  - Walter, Thomas
T1  - Benchmarking of various LiDAR sensors for use in self-driving vehicles in real-world environments
JF  - Sensors
N2  - Abstract
In this paper, we report on our benchmark results of the LiDAR sensors Livox Horizon, Robosense M1, Blickfeld Cube, Blickfeld Cube Range, Velodyne Velarray H800, and Innoviz Pro. The idea was to test the sensors in different typical scenarios that were defined with real-world use cases in mind, in order to find a sensor that meet the requirements of self-driving vehicles. For this, we defined static and dynamic benchmark scenarios. In the static scenarios, both LiDAR and the detection target do not move during the measurement. In dynamic scenarios, the LiDAR sensor was mounted on the vehicle which was driving toward the detection target. We tested all mentioned LiDAR sensors in both scenarios, show the results regarding the detection accuracy of the targets, and discuss their usefulness for deployment in self-driving cars.
KW  - Lidar
KW  - Benchmark
KW  - Self-driving
Y1  - 2022
U6  - https://doi.org/10.3390/s22197146
SN  - 1424-8220
N1  - This article belongs to the Special Issue "Sensor Fusion for Vehicles Navigation and Robotic Systems"
VL  - 22
IS  - 19
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Abulnaga, El-Hussiny
A1  - Pinkenburg, Olaf
A1  - Schiffels, Johannes
A1  - E-Refai, Ahmed
A1  - Buckel, Wolfgang
A1  - Selmer, Thorsten
T1  - Effect of an Oxygen-Tolerant Bifurcating Butyryl Coenzyme A Dehydrogenase/Electron-Transferring Flavoprotein Complex from Clostridium difficile on Butyrate Production in Escherichia coli
JF  - Journal of bacteriology
Y1  - 2013
SN  - 1098-5530 [E-Journal]
SN  - 0021-9193 [Print]
VL  - 195
IS  - 16
SP  - 3704
EP  - 3713
ER  - 
TY  - CHAP
A1  - Ritz, Thomas
A1  - Izquierdo Tello, César
A1  - Damm, Sebastian
T1  - Connecting a pedelec to the cloud as basis for gamification in multi modal mobility planning
T2  - MobileCloud 2014 : 2nd IEEE International Conference on Mobile Cloud Computing, Services, and Engineering Oxford, United Kingdom 7-10 April 2014
Y1  - 2014
SN  - 978-1-4799-2504-9
U6  - https://doi.org/10.1109/MobileCloud.2014.25
SP  - 101
EP  - 108
PB  - IEEE Service Center
CY  - Piscataway, NJ
ER  - 
TY  - JOUR
A1  - Meyer-Stork, L. Sebastian
A1  - Höcker, Hartwig
A1  - Berndt, Heinz
T1  - Syntheses and reactions of urethanes of cellobiose and cellulose-containing uretdione groups
JF  - Journal of applied polymer science
Y1  - 1992
SN  - 1097-4628
VL  - 44
IS  - 6
SP  - 1043
EP  - 1049
ER  - 
TY  - CHAP
A1  - Peeken, Heinz
A1  - Troeder, Christoph
A1  - Schmidt, J.
A1  - Rosenkranz, Josef
T1  - Principles of machine noise reduction
T2  - Inter-noise 85 : proceedings ; 1985 international conference on noise control engineering ; Munich, Sept. 18 - 20, 1985. - (Schriftenreihe der Bundesanstalt für Arbeitsschutz : Tagungsbericht ; 39)
Y1  - 1985
SN  - 3-88314-417-7
SP  - 23
EP  - 36
PB  - Bundesanstalt für Arbeitsschutz [u.a.]
CY  - Dortmund [u.a.]
ER  -