TY - JOUR A1 - Scheer, Nico A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Buechel, Sandra A1 - Wolf, C. Roland T1 - Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines JF - Molecular Pharmacology N2 - Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal models to predict the role of human CYP2C enzymes in drug metabolism and drug-drug interactions is limited. Within the human CYP2C cluster CYP2C9 is of particular importance, because it is one of the most abundant P450 enzymes in human liver, and it is involved in the metabolism of a wide variety of important drugs and environmental chemicals. To investigate the in vivo functions of cytochrome P450 Cyp2c genes and to establish a model for studying the functions of CYP2C9 in vivo, we have generated a mouse model with a deletion of the murine Cyp2c gene cluster and a corresponding humanized model expressing CYP2C9 specifically in the liver. Despite the high number of functional genes in the mouse Cyp2c cluster and the reported roles of some of these proteins in different biological processes, mice deleted for Cyp2c genes were viable and fertile but showed certain phenotypic alterations in the liver. The expression of CYP2C9 in the liver also resulted in viable animals active in the metabolism and disposition of a number of CYP2C9 substrates. These mouse lines provide a powerful tool for studying the role of Cyp2c genes and of CYP2C9 in particular in drug disposition and as a factor in drug-drug interaction. Y1 - 2012 U6 - https://doi.org/10.1124/mol.112.080036 SN - 1521-0111 VL - 82 IS - 6 SP - 1022 EP - 1029 PB - ASPET CY - Bethesda, Md. ER - TY - PAT A1 - Nötzold, K. A1 - Bragard, Michael A1 - Fink, K. A1 - Griessel, R. A1 - Wegener, R. T1 - Cascaded H-bridge converter with transformer based cell power balancing in each voltage level : [Patentschrift] Y1 - 2014 N1 - Titel des US-Patents: Bypassed cascaded cell converter : [patent of invention]. - Außerdem veröffentlicht als CN103997231 (A) PB - Europäisches Patentamt / United States Patent and Trademark Office [u.a.] CY - Den Haag / Alexandria, VA ER - TY - JOUR A1 - Stojnic, Srdjan A1 - Sass-Klaassen, Ute G. M. A1 - Orlovic, Sasa A1 - Matovic, Bratislav A1 - Eilmann, Britta T1 - Plastic growth response of European beech provenances to dry site conditions T2 - IAWA Journal / International Association of Wood Anatomists Y1 - 2013 U6 - https://doi.org/10.1163/22941932-00000038 SN - 0928-1541 (Print) SN - 2294-1932 (Online) VL - 34 IS - 4 SP - 475 EP - 484 PB - Brill CY - Leiden ER - TY - JOUR A1 - Eilmann, Britta A1 - Buchmann, Nina A1 - Siegwolf, Rolf A1 - Saurer, Matthias A1 - Cherubini, Paolo A1 - Rigling, Andreas T1 - Fast response of Scots pine to improved water availability reflected in tree-ring width and δ13C JF - Plant, Cell and Environment N2 - Drought-induced forest decline, like the Scots pine mortality in inner-Alpine valleys, will gain in importance as the frequency and severity of drought events are expected to increase. To understand how chronic drought affects tree growth and tree-ring δ13C values, we studied mature Scots pine in an irrigation experiment in an inner-Alpine valley. Tree growth and isotope analyses were carried out at the annual and seasonal scale. At the seasonal scale, maximum δ13C values were measured after the hottest and driest period of the year, and were associated with decreasing growth rates. Inter-annual δ13C values in early- and latewood showed a strong correlation with annual climatic conditions and an immediate decrease as a response to irrigation. This indicates a tight coupling between wood formation and the freshly produced assimilates for trees exposed to chronic drought. This rapid appearance of the isotopic signal is a strong indication for an immediate and direct transfer of newly synthesized assimilates for biomass production. The fast appearance and the distinct isotopic signal suggest a low availability of old stored carbohydrates. If this was a sign for C-storage depletion, an increasing mortality could be expected when stressors increase the need for carbohydrate for defence, repair or regeneration. Y1 - 2010 U6 - https://doi.org/10.1111/j.1365-3040.2010.02153.x SN - 1365-3040 (Online) SN - 0140-7791 (Print) VL - 33 IS - 8 SP - 1351 EP - 1360 PB - Wiley-Blackwell CY - Oxford ER - TY - CHAP A1 - Xu, Zhanping A1 - Schwarte, Rudolf A1 - Heinol, Horst-Guenther A1 - Buxbaum, Bernd A1 - Ringbeck, Thorsten ED - Cheung, Edmund H. M. T1 - Smart pixel : photonic mixer device (PMD) ; new system concept of a 3D-imaging camera-on-a-chip T2 - Proceedings : M2VIP '98; Nanjing, China, 10th - 12th September 1998 Y1 - 1998 SN - 962-442-129-3 N1 - International Conference on Mechatronics and Machine Vision in Practice <5, 1998, Nanking> ; M2VIP <5, 1998, Nanking> SP - 259 EP - 264 CY - Hong Kong ER - TY - CHAP A1 - Herrmann, Ulf A1 - Rheinländer, J. A1 - Lippke, F. ED - Becker, Manfred T1 - Solar Fields for Direct Steam Generation in Parabolic Trough Collectors T2 - Components, tools, facilities and measurement techniques. - (Solar thermal concentrating technologies : proceedings of the 8th international symposium, October, 6 - 11, 1996, Köln, Germany ; Vol. 2) Y1 - 1997 SN - 3-7880-7616-X SP - 815 EP - 834 PB - Müller CY - Heidelberg ER - TY - JOUR A1 - Fonti, Patrick A1 - von Arx, Georg A1 - García-González, Ignacio A1 - Eilmann, Britta A1 - Sass-Klaassen, Ute G. W. A1 - Gärtner, Holger A1 - Eckstein, Dieter T1 - Studying global change through investigation of the plastic responses of xylem anatomy in tree rings JF - New Phytologist N2 - Variability in xylem anatomy is of interest to plant scientists because of the role water transport plays in plant performance and survival. Insights into plant adjustments to changing environmental conditions have mainly been obtained through structural and functional comparative studies between taxa or within taxa on contrasting sites or along environmental gradients. Yet, a gap exists regarding the study of hydraulic adjustments in response to environmental changes over the lifetimes of plants. In trees, dated tree-ring series are often exploited to reconstruct dynamics in ecological conditions, and recent work in which wood-anatomical variables have been used in dendrochronology has produced promising results. Environmental signals identified in water-conducting cells carry novel information reflecting changes in regional conditions and are mostly related to short, sub-annual intervals. Although the idea of investigating environmental signals through wood anatomical time series goes back to the 1960s, it is only recently that low-cost computerized image-analysis systems have enabled increased scientific output in this field. We believe that the study of tree-ring anatomy is emerging as a promising approach in tree biology and climate change research, particularly if complemented by physiological and ecological studies. This contribution presents the rationale, the potential, and the methodological challenges of this innovative approach. Y1 - 2010 U6 - https://doi.org/10.1111/j.1469-8137.2009.03030.x SN - 1469-8137 (Online) SN - 0028-646X (Print) VL - 185 IS - 1 SP - 42 EP - 53 PB - Wiley-Blackwell CY - Oxford ER - TY - GEN A1 - Hezel, Fabian A1 - Frauenrath, Tobias A1 - Renz, Wolfgang A1 - Schulz-Menger, Jeanette A1 - Niendorf, Thoralf T1 - Feasibility of CINE Myocardial T2* Mapping Using Susceptibility Weighted Gradient-Echo Imaging at 7.0 T T2 - 2010 ISMRM-ESMRMB joint annual meeting N2 - This study is designed to demonstrate the promise of susceptibility weighted 2D CINE FLASH and T2* Mapping of the heart at 7T. Y1 - 2010 SN - 1545-4428 N1 - ISMRM-ESMRMB joint annual meeting, 1 - 7 May 2010, Stockholm, Sweden ER - TY - JOUR A1 - Berndt, Heinz A1 - Krüger, Götz T1 - Resolution of enantiomeric amino acid derivatives by high-performance liquid chromatography on chiral stationary phases JF - Journal of chromatography A Y1 - 1985 U6 - https://doi.org/10.1016/S0021-9673(01)92461-6 SN - 0021-9673 VL - 1985 IS - 348 SP - 275 EP - 279 ER - TY - CHAP A1 - Anik, Sabri A1 - Frohberg, Martin G. ED - Brodowsky, Horst T1 - Thermodynamic behaviour of oxygen in molten metallic alloys T2 - Thermochemistry of alloys : recent developments of experimental methods ; [proceedings of the NATO Advanced Study Institute on Thermochemistry of Alloys, Recent Developments of Experimental Methods, Kiel, F.R.G., August 17 - 27, 1987]. - (NATO ASI series : Series C ; 286) Y1 - 1989 SN - 0-7923-0434-9 SP - 419 EP - 428 PB - Springer CY - Dordrecht [u.a.] ER -