TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Bing, Yu A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Visualization of Defects on a Cultured Cell Layer by Utilizing Chemical Imaging Sensor JF - Procedia Engineering N2 - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) inthe sample. In this study, a novel wound-healing assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the defect of a cell layer brought into proximity of the sensing surface.A reduced impedance inside the defect, which was artificially formed ina cell layer, was successfully visualized in a photocurrent image. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.806 SN - 1877-7058 N1 - Part of special issue "Eurosensors 2015" VL - 120 SP - 936 EP - 939 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Scheja, S. A1 - Wu, Chunsheng A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Electrostatic Detection of Unlabelled Single- and Double-stranded DNA Using Capacitive Field-effect Devices Functionalized with a Positively Charged Polyelectrolyte Layer JF - Procedia Engineering N2 - Capacitive field-effect electrolyte-insulator-semiconductor sensors consisting of an Al-p-Si-SiO2 structure have been used for the electrical detection of unlabelled single- and double-stranded DNA (dsDNA) molecules by their intrinsic charge. A simple functionalization protocol based on the layer-by-layer (LbL) technique was used to prepare a weak polyelectrolyte/probe-DNA bilayer, followed by the hybridization with complementary target DNA molecules. Due to the flat orientation of the LbL-adsorbed DNA molecules, a high sensor signal has been achieved. In addition, direct label-free detection of in-solution hybridized dsDNA molecules has been studied. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.710 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 544 EP - 547 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Frotscher, Ralf A1 - Staat, Manfred ED - Nithiarasu, Perumal T1 - Homogenization of a cardiac tissue construct T2 - CMBE15 : 4th International Conference on Computational & Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; École Normale Supérieure de Cachan ; Cachan (Paris), France Y1 - 2015 SN - 2227-9385 N1 - Konferenzband unter: http://www.compbiomed.net/getfile.php?type=12/site_documents&id=Proceedings_2227-9385_compressed.pdf SP - 645 EP - 648 PB - CMBE CY - [s.l.] ER - TY - CHAP A1 - Wallnöfer, Armin A1 - Drath, Rainer A1 - Hüning, Felix T1 - Was ist Funktionales Engineering? Einordnung, Definition, Randbedingungen T2 - Automation 2015 : 16. Branchentreff der Mess- und Automatisierungstechnik, 11. und 12. Juni 2015, Baden-Baden / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik Y1 - 2015 SN - 978-3-18-092258-4 PB - VDI-Verl. CY - Düsseldorf ER - TY - CHAP A1 - Wolf, Martin A1 - Lenz, Laura L. T1 - The economic effectiveness of serious games in the healthcare environment : application and evaluation of the Comparative Transformation Model (CTM) T2 - IEEE 3rd International Conference on Serious Games and Applications for Health : SeGAH 2014 ; Rio de Janeiro, Brazil, May 14 - 16 Y1 - 2015 SN - 978-1-4799-4823-9 U6 - http://dx.doi.org/10.1109/SeGAH.2014.7067089 SP - 135 EP - 142 PB - IEEE [u.a.] CY - Piscataway, NJ ER - TY - CHAP A1 - Rahier, Michael A1 - Ritz, Thomas A1 - Wallenborn, Ramona T1 - Information and communication technology for integrated mobility concepts such as E-carsharing T2 - E-Mobility in Europe : trends and good practice N2 - During the past decade attitude towards sharing things has changed extremely. Not just personal data is shared (e.g. in social networks) but also mobility. Together with the increased ecological awareness of the recent years, new mobility concepts have evolved. E-carsharing has become a symbol for these changes of attitude. The management of a shared car fleet, the energy management of electric mobility and the management of various carsharing users with individual likes and dislikes are just some of the major challenges of e-carsharing. Weaving it into integrated mobility concepts, this raises complexity even further. These challenges can only be overcome by an appropriate amount of well-shaped information available at the right place and time. In order to gather, process and share the required information, fleet cars have to be equipped with modern information and communication technology (ICT) and become so-called fully connected cars. Ensuring the usability of these ICT systems is another challenge that is often neglected, even though it is usability that makes carsharing comfortable, attractive and supports users’ new attitudes. By means of an integrated and consistent concept for human-machine interaction (HMI), the usability of such systems can be raised tremendously. KW - Information and communication technology KW - Fully connected car KW - E-carsharing KW - Mobility management KW - Integrated mobility Y1 - 2015 SN - 978-3-319-13193-1 U6 - http://dx.doi.org/10.1007/978-3-319-13194-8_17 SP - 311 EP - 326 PB - Springer CY - Cham [u.a.] ER - TY - CHAP A1 - Busse, Daniel A1 - Esch, Thomas A1 - Muntaniol, Roman T1 - Thermal management in E-carsharing vehicles - preconditioning concepts of passenger compartments T2 - E-Mobility in Europe : trends and good practice N2 - The issue of thermal management in electric vehicles includes the topics of drivetrain cooling and heating, interior temperature, vehicle body conditioning and safety. In addition to the need to ensure optimal thermal operating conditions of the drivetrain components (drive motor, battery and electrical components), thermal comfort must be provided for the passengers. Thermal comfort is defined as the feeling which expresses the satisfaction of the passengers with the ambient conditions in the compartment. The influencing factors on thermal comfort are the temperature and humidity as well as the speed of the indoor air and the clothing and the activity of the passengers, in addition to the thermal radiation and the temperatures of the interior surfaces. The generation and the maintenance of free visibility (ice- and moisture-free windows) count just as important as on-demand heating and cooling of the entire vehicle. A Carsharing climate concept of the innovative ec2go vehicle stipulates and allows for only seating areas used by passengers to be thermally conditioned in a close-to-body manner. To enable this, a particular feature has been added to the preconditioning of the Carsharing electric vehicle during the electric charging phase at the parking station. KW - Carsharing KW - Thermal management KW - Thermal comfort KW - Electrical vehicle KW - Passenger compartment Y1 - 2015 SN - 978-3-319-13193-1 U6 - http://dx.doi.org/10.1007/978-3-319-13194-8_18 SP - 327 EP - 343 PB - Springer CY - Cham [u.a.] ER - TY - BOOK A1 - Kurz, Melanie T1 - Handwerk oder Design : zur Ästhetik des Handgemachten N2 - Manuelle Herstellung ist sozial fair, ökologisch nachhaltig und schafft qualitätsvolle Erzeugnisse! Vorbote für eine großformatige Rückkehr zum Handwerk und zur eigenhändigen Fertigung ist die Maker-Bewegung! – Solche Thesen begegnen uns gegenwärtig oft. Journalistische Texte, Filmdokumentationen, Werbung oder die Ästhetik von Produkten sind ihre Vehikel. Doch wie ist es um die Wiederbelebung des Handwerks tatsächlich bestellt? Und in welchem Verhältnis steht das Design – ein durch und durch industriebasiertes Berufsfeld – zu vorindustriellen Produktionsweisen? Diesen Fragen geht das vorliegende Buch ebenso auf den Grund wie der seit Beginn der Industrialisierung auftretenden Handwerksromantik. Es untersucht zudem, wie aktuelles Design die Sehnsucht nach dem Ursprünglichen mit formalen Kodes beantwortet und wie die visuellen Erscheinungsformen des Handgemachten ihre Wirkung freisetzen. Y1 - 2015 SN - 978-3-7705-5943-5 (Druckausgabe) SN - 978-3-8467-5943-1 (E-Book) U6 - http://dx.doi.org/10.30965/9783846759431 PB - Fink CY - Paderborn ER - TY - JOUR A1 - Takenaga, Shoko A1 - Schneider, Benno A1 - Erbay, E. A1 - Biselli, Manfred A1 - Schnitzler, Thomas A1 - Schöning, Michael Josef A1 - Wagner, Torsten T1 - Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process JF - Physica status solidi (a) N2 - A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation. Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201532053 SN - 1862-6319 VL - 212 IS - 6 SP - 1347 EP - 1352 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Molinnus, Denise A1 - Bäcker, Matthias A1 - Iken, Heiko A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Concept for a biomolecular logic chip with an integrated sensor and actuator function JF - Physica status solidi (a) N2 - A concept for a new generation of an integrated multi-functional biosensor/actuator system is developed, which is based on biomolecular logic principles. Such a system is expected to be able to detect multiple biochemical input signals simultaneously and in real-time and convert them into electrical output signals with logical operations such as OR, AND, etc. The system can be designed as a closed-loop drug release device triggered by an enzyme logic gate, while the release of the drug induced by the actuator at the required dosage and timing will be controlled by an additional drug sensor. Thus, the system could help to make an accurate and specific diagnosis. The presented concept is exemplarily demonstrated by using an enzyme logic gate based on a glucose/glucose oxidase system, a temperature-responsive hydrogel mimicking the actuator function and an insulin (drug) sensor. In this work, the results of functional testing of individual amperometric glucose and insulin sensors as well as an impedimetric sensor for the detection of the hydrogel swelling/shrinking are presented. Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201431913 SN - 1862-6319 VL - 212 IS - 6 SP - 1382 EP - 1388 PB - Wiley CY - Weinheim ER -