TY  - JOUR
A1  - Wilson, C. E.
A1  - Dickie, A. P.
A1  - Schreiter, K.
A1  - Wehr, R.
A1  - Wilson, E. M.
A1  - Bial, J.
A1  - Scheer, Nico
A1  - Wilson, I. D.
A1  - Riley, R. J.
T1  - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
JF  - Archives of Toxicology
N2  - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
Y1  - 2018
U6  - https://doi.org/10.1007/s00204-018-2212-1
SN  - 1432-0738
VL  - 92
IS  - 6
SP  - 1953
EP  - 1967
PB  - Springer
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - TSN – Schluss mit dem Feldbuskrieg?
JF  - Design & Elektronik
Y1  - 2018
SN  - 0933-8667
N1  - Echtzeit für Industrie 4.0. - Teil 3
IS  - 3
SP  - 26
EP  - 31
PB  - WEKA-Fachmedien
CY  - München
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - Echtzeit-Ethernet – Basis für Industrie 4.0
JF  - Design & Elektronik
Y1  - 2018
SN  - 0933-8667
N1  - Echtzeit für Industrie 4.0. - Teil 2
PB  - WEKA-Fachmedien
CY  - München
ER  - 
TY  - JOUR
A1  - Zhang, G.
A1  - Valero, Daniel
A1  - Bung, Daniel Bernhard
A1  - Chanson, H.
T1  - On the estimation of free-surface turbulence using ultrasonic sensors
JF  - Flow Measurement and Instrumentation
N2  - Accurate determination of free-surface dynamics has attracted much research attention during the past decade and has important applications in many environmental and water related areas. In this study, the free-surface dynamics in several turbulent flows commonly found in nature were investigated using a synchronised setup consisting of an ultrasonic sensor and a high-speed video camera. Basic sensor capabilities were examined in dry conditions to allow for a better characterisation of the present sensor model. The ultrasonic sensor was found to adequately reproduce free-surface dynamics up to the second order, especially in two-dimensional scenarios with the most energetic modes in the low frequency range. The sensor frequency response was satisfactory in the sub-20 Hz band, and its signal quality may be further improved by low-pass filtering prior to digitisation. The application of the USS to characterise entrapped air in high-velocity flows is also discussed.
Y1  - 2018
U6  - https://doi.org/10.1016/j.flowmeasinst.2018.02.009
SN  - 0955-5986
VL  - 60
SP  - 171
EP  - 184
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ziebura, Dawid
A1  - Bremen, Sebastian
A1  - Schleifenbaum, Johannes Henrich
A1  - Gebhardt, Andreas
T1  - Machbarkeitsstudie zur Verarbeitung von nicht rostendem Stahl 1.4404 unter Verwendung einer Diodenlaser-basierten LPBF-Maschine mit kartesischem Achssystem
JF  - RTejournal - Forum für Rapid Technologie
Y1  - 2018
SN  - 1614-0923
VL  - 15
ER  -