TY - JOUR A1 - Kopp, Alexander A1 - Schunck, Laura A1 - Gosau, Martin A1 - Smeets, Ralf A1 - Burg, Simon A1 - Fuest, Sandra A1 - Kröger, Nadja A1 - Zinser, Max A1 - Krohn, Sebastian A1 - Behbahani, Mehdi A1 - Köpf, Marius A1 - Lauts, Lisa A1 - Rutkowski, Rico T1 - Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes JF - International Journal of Molecular Sciences N2 - In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes. Y1 - 2020 U6 - https://doi.org/10.3390/ijms21186704 SN - 1422-0067 N1 - Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine VL - 21 IS - 18 art. no. 6704 PB - MDPI CY - Basel ER - TY - CHAP A1 - Fateri, Miranda A1 - Gebhardt, Andreas T1 - Introduction to Additive Manufacturing T2 - 3D Printing of Optical Components N2 - Additive manufacturing (AM) works by creating objects layer by layer in a manner similar to a 2D printer with the “printed” layers stacked on top of each other. The layer-wise manufacturing nature of AM enables fabrication of freeform geometries which cannot be fabricated using conventional manufacturing methods as a one part. Depending on how each layer is created and bonded to the adjacent layers, different AM methods have been developed. In this chapter, the basic terms, common materials, and different methods of AM are described, and their potential applications are discussed. KW - Additive manufacturing KW - 3D printing KW - Digital manufacturing KW - Rapid prototyping KW - Rapid manufacturing Y1 - 2020 SN - 978-3-030-58960-8 U6 - https://doi.org/10.1007/978-3-030-58960-8_1 SP - 1 EP - 22 PB - Springer CY - Cham ER - TY - JOUR A1 - Molinnus, Denise A1 - Beging, Stefan A1 - Lowis, Carsten A1 - Schöning, Michael Josef T1 - Towards a multi-enzyme capacitive field-effect biosensor by comparative study of drop-coating and nano-spotting technique JF - Sensors N2 - Multi-enzyme immobilization onto a capacitive field-effect biosensor by nano-spotting technique is presented. The nano-spotting technique allows to immobilize different enzymes simultaneously on the sensor surface with high spatial resolution without additional photolithographical patterning. The amount of applied enzymatic cocktail on the sensor surface can be tailored. Capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors with Ta2O5 as pH-sensitive transducer layer have been chosen to immobilize the three different (pL droplets) enzymes penicillinase, urease, and glucose oxidase. Nano-spotting immobilization is compared to conventional drop-coating method by defining different geometrical layouts on the sensor surface (fully, half-, and quarter-spotted). The drop diameter is varying between 84 µm and 102 µm, depending on the number of applied drops (1 to 4) per spot. For multi-analyte detection, penicillinase and urease are simultaneously nano-spotted on the EIS sensor. Sensor characterization was performed by C/V (capacitance/voltage) and ConCap (constant capacitance) measurements. Average penicillin, glucose, and urea sensitivities for the spotted enzymes were 81.7 mV/dec, 40.5 mV/dec, and 68.9 mV/dec, respectively. Y1 - 2020 SN - 1424-8220 U6 - https://doi.org/10.3390/s20174924 N1 - Special issue: Multisensor Systems and Signal Processing in Analytical Chemistry VL - 20 IS - 17 PB - MDPI CY - Basel ER - TY - CHAP A1 - Geiben, Benedikt A1 - Götten, Falk A1 - Havermann, Marc T1 - Aerodynamic analysis of a winged sub-orbital spaceplane N2 - This paper primarily presents an aerodynamic CFD analysis of a winged spaceplane geometry based on the Japanese Space Walker proposal. StarCCM was used to calculate aerodynamic coefficients for a typical space flight trajectory including super-, trans- and subsonic Mach numbers and two angles of attack. Since the solution of the RANS equations in such supersonic flight regimes is still computationally expensive, inviscid Euler simulations can principally lead to a significant reduction in computational effort. The impact on accuracy of aerodynamic properties is further analysed by comparing both methods for different flight regimes up to a Mach number of 4. Y1 - 2020 U6 - https://doi.org/10.25967/530170 N1 - 69. Deutscher Luft- und Raumfahrtkongress 2020, 1. September 2020 - 3. September 2020, online PB - DGLR CY - Bonn ER - TY - BOOK A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef ED - Yoshinobu, Tatsuo ED - Schöning, Michael Josef T1 - Light-addressing and chemical imaging technologies for electrochemical sensing Y1 - 2020 SN - 978-3-03943-029-1 U6 - https://doi.org/10.3390/books978-3-03943-029-1 N1 - This book is a printed edition of the Special Issue Light-Addressing and Chemical Imaging Technologies for Electrochemical Sensing that was published in Sensors PB - MDPI CY - Basel ER - TY - CHAP A1 - Frantz, Cathy A1 - Binder, Matthias A1 - Busch, Konrad A1 - Ebert, Miriam A1 - Heinrich, Andreas A1 - Kaczmarkiewicz, Nadine A1 - Schlögl-Knothe, Bärbel A1 - Kunze, Tobias A1 - Schuhbauer, Christian A1 - Stetka, Markus A1 - Schwager, Christian A1 - Spiegel, Michael A1 - Teixeira Boura, Cristiano José A1 - Bauer, Thomas A1 - Bonk, Alexander A1 - Eisen, Stefan A1 - Funck, Bernhard T1 - Basic Engineering of a High Performance Molten Salt Tower Receiver System T2 - AIP Conference Proceedings N2 - The production of dispatchable renewable energy will be one of the most important key factors of the future energy supply. Concentrated solar power (CSP) plants operated with molten salt as heat transfer and storage media are one opportunity to meet this challenge. Due to the high concentration factor of the solar tower technology the maximum process temperature can be further increased which ultimately decreases the levelized costs of electricity of the technology (LCOE). The development of an improved tubular molten salt receiver for the next generation of molten salt solar tower plants is the aim of this work. The receiver is designed for a receiver outlet temperature up to 600 °C. Together with a complete molten salt system, the receiver will be integrated into the Multi-Focus-Tower (MFT) in Jülich (Germany). The paper describes the basic engineering of the receiver, the molten salt tower system and a laboratory corrosion setup. Y1 - 2020 U6 - https://doi.org/10.1063/5.0085895 N1 - SOLARPACES 2020: 26th International Conference on Concentrating Solar Power and Chemical Energy Systems, 28 September – 2 October 2020, Freiburg, Germany SP - 1 EP - 10 ER - TY - JOUR A1 - Gazda, Quentin A1 - Maurischat, Andreas T1 - Special functions and Gauss-Thakur sums in higher rank and dimension Y1 - 2020 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Adams, Moritz A1 - Losekamm, Martin J. A1 - Czupalla, Markus T1 - Development of the Thermal Control System for the RadMap Telescope Experiment on the International Space Station T2 - International Conference on Environmental Systems Y1 - 2020 N1 - 2020 International Conference on Environmental Systems, 12. Juli 2020 – 16. Juli 2020, Lissabon SP - 1 EP - 10 ER - TY - CHAP A1 - Borchert, Jörg A1 - Tenbrake, Andre T1 - Bewirtschaftung von Flexibilität über Microservices eines Plattformanbieters T2 - Realisierung Utility 4.0 Band 1 N2 - Die Energiewirtschaft befindet sich in einem starken Wandel, der v. a. durch die Energiewende und Digitalisierung Druck auf sämtliche Marktteilnehmer ausübt. Das klassische Geschäftsmodell des Energieversorgungsunternehmens verändert sich dabei grundlegend. Der kontinuierlich ansteigende Einsatz dezentraler und volatiler Erzeugungsanlagen macht die Identifikation von Flexibilitätspotenzialen notwendig, um weiterhin eine hohe Versorgungssicherheit zu gewährleisten. Dieser Schritt ist nur mit einem hohen Digitalisierungsgrad möglich. Eine funktionale Plattform mit Microservices, die zu Geschäftsprozessen verbunden werden können, wird als Möglichkeit zur Aktivierung der Flexibilität und Digitalisierung der Energieversorgungsunternehmen im Folgenden vorgestellt. Y1 - 2020 SN - 978-3-658-25332-5 U6 - https://doi.org/10.1007/978-3-658-25332-5_37 SP - 615 EP - 626 PB - Springer Vieweg CY - Wiesbaden ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Abel, Thomas A1 - Albracht, Kirsten A1 - Meskemper, Joshua A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Biomechanics of handcycling propulsion in a 30-min continuous load test at lactate threshold: Kinetics, kinematics, and muscular activity in able-bodied participants JF - European Journal of Applied Physiology N2 - Purpose This study aims to investigate the biomechanics of handcycling during a continuous load trial (CLT) to assess the mechanisms underlying fatigue in upper body exercise. Methods Twelve able-bodied triathletes performed a 30-min CLT at a power output corresponding to lactate threshold in a racing recumbent handcycle mounted on a stationary ergometer. During the CLT, ratings of perceived exertion (RPE), tangential crank kinetics, 3D joint kinematics, and muscular activity of ten muscles of the upper extremity and trunk were examined using motion capturing and surface electromyography. Results During the CLT, spontaneously chosen cadence and RPE increased, whereas crank torque decreased. Rotational work was higher during the pull phase. Peripheral RPE was higher compared to central RPE. Joint range of motion decreased for elbow-flexion and radial-duction. Integrated EMG (iEMG) increased in the forearm flexors, forearm extensors, and M. deltoideus (Pars spinalis). An earlier onset of activation was found for M. deltoideus (Pars clavicularis), M. pectoralis major, M. rectus abdominis, M. biceps brachii, and the forearm flexors. Conclusion Fatigue-related alterations seem to apply analogously in handcycling and cycling. The most distal muscles are responsible for force transmission on the cranks and might thus suffer most from neuromuscular fatigue. The findings indicate that peripheral fatigue (at similar lactate values) is higher in handcycling compared to leg cycling, at least for inexperienced participants. An increase in cadence might delay peripheral fatigue by a reduced vascular occlusion. We assume that the gap between peripheral and central fatigue can be reduced by sport-specific endurance training. Y1 - 2020 U6 - https://doi.org/10.1007/s00421-020-04373-x SN - 1439-6327 IS - 120 SP - 1403 EP - 1415 PB - Springer CY - Heidelberg ER -