TY - JOUR A1 - Ditzhaus, Marc A1 - Gaigall, Daniel T1 - A consistent goodness-of-fit test for huge dimensional and functional data JF - Journal of Nonparametric Statistics N2 - A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cramér-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals. KW - Cramér-von-Mises statistic KW - separable Hilbert space KW - huge dimensional data KW - functional data Y1 - 2018 U6 - https://doi.org/10.1080/10485252.2018.1486402 SN - 1029-0311 VL - 30 IS - 4 SP - 834 EP - 859 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Gaigall, Daniel A1 - Gerstenberg, Julian A1 - Trinh, Thi Thu Ha T1 - Empirical process of concomitants for partly categorial data and applications in statistics JF - Bernoulli N2 - On the basis of independent and identically distributed bivariate random vectors, where the components are categorial and continuous variables, respectively, the related concomitants, also called induced order statistic, are considered. The main theoretical result is a functional central limit theorem for the empirical process of the concomitants in a triangular array setting. A natural application is hypothesis testing. An independence test and a two-sample test are investigated in detail. The fairly general setting enables limit results under local alternatives and bootstrap samples. For the comparison with existing tests from the literature simulation studies are conducted. The empirical results obtained confirm the theoretical findings. KW - bootstrap KW - Categorial variable KW - Concomitant KW - Empirical process KW - Independence test Y1 - 2022 U6 - https://doi.org/10.3150/21-BEJ1367 SN - 1573-9759 VL - 28 IS - 2 SP - 803 EP - 829 PB - International Statistical Institute CY - Den Haag, NL ER - TY - JOUR A1 - Artmann, Gerhard A1 - Grebe, R. A1 - Homrighausen, A. A1 - Wolff, H. A1 - Teitel, P. A1 - Schmid-Schönbein, H. T1 - Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Schönbein, H. JF - 12. Jahrestagung der Gesellschaft für Mikrozirkulation Y1 - 1988 SP - 196 EP - 200 PB - Karger [u.a.] CY - Basel [u.a.] ER - TY - JOUR A1 - Jung, Alexander A1 - Müller, Wolfram A1 - Staat, Manfred T1 - Optimization of the flight technique in ski jumping: the influence of wind Y1 - 2019 U6 - https://doi.org/10.1016/j.jbiomech.2019.03.023 IS - Early view PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Jildeh, Zaid B. A1 - Oberländer, Jan A1 - Kirchner, Patrick A1 - Keusgen, Michael A1 - Wagner, Patrick H. A1 - Schöning, Michael Josef T1 - Experimental and Numerical Analyzes of a Sensor Based on Interdigitated Electrodes for Studying Microbiological Alterations JF - physica status solidi (a): applications and materials science N2 - In this work, a cell-based biosensor to evaluate the sterilization efficacy of hydrogen peroxide vapor sterilization processes is characterized. The transducer of the biosensor is based on interdigitated gold electrodes fabricated on an inert glass substrate. Impedance spectroscopy is applied to evaluate the sensor behavior and the alteration of test microorganisms due to the sterilization process. These alterations are related to changes in relative permittivity and electrical conductivity of the bacterial spores. Sensor measurements are conducted with and without bacterial spores (Bacillus atrophaeus), as well as after an industrial sterilization protocol. Equivalent two-dimensional numerical models based on finite element method of the periodic finger structures of the interdigitated gold electrodes are designed and validated using COMSOL® Multiphysics software by the application of known dielectric properties. The validated models are used to compute the electrical properties at different sensor states (blank, loaded with spores, and after sterilization). As a final result, we will derive and tabulate the frequency-dependent electrical parameters of the spore layer using a novel model that combines experimental data with numerical optimization techniques. Y1 - 2018 U6 - https://doi.org/10.1002/pssa.201700920 SN - 1862-6319 VL - 215 IS - 15 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Ditzhaus, Marc A1 - Gaigall, Daniel T1 - Testing marginal homogeneity in Hilbert spaces with applications to stock market returns JF - Test N2 - This paper considers a paired data framework and discusses the question of marginal homogeneity of bivariate high-dimensional or functional data. The related testing problem can be endowed into a more general setting for paired random variables taking values in a general Hilbert space. To address this problem, a Cramér–von-Mises type test statistic is applied and a bootstrap procedure is suggested to obtain critical values and finally a consistent test. The desired properties of a bootstrap test can be derived that are asymptotic exactness under the null hypothesis and consistency under alternatives. Simulations show the quality of the test in the finite sample case. A possible application is the comparison of two possibly dependent stock market returns based on functional data. The approach is demonstrated based on historical data for different stock market indices. Y1 - 2022 U6 - https://doi.org/10.1007/s11749-022-00802-5 SN - 1863-8260 VL - 2022 IS - 31 SP - 749 EP - 770 PB - Springer ER - TY - JOUR A1 - Kleefeld, Andreas A1 - Pieronek, J. T1 - Elastic transmission eigenvalues and their computation via the method of fundamental solutions JF - Applicable Analysis N2 - A stabilized version of the fundamental solution method to catch ill-conditioning effects is investigated with focus on the computation of complex-valued elastic interior transmission eigenvalues in two dimensions for homogeneous and isotropic media. Its algorithm can be implemented very shortly and adopts to many similar partial differential equation-based eigenproblems as long as the underlying fundamental solution function can be easily generated. We develop a corroborative approximation analysis which also implicates new basic results for transmission eigenfunctions and present some numerical examples which together prove successful feasibility of our eigenvalue recovery approach. KW - elastic scattering KW - method of fundamental solutions KW - Interior transmission eigenvalues Y1 - 2020 U6 - https://doi.org/10.1080/00036811.2020.1721473 SN - 1563-504X VL - 100 IS - 16 SP - 3445 EP - 3462 PB - Taylore & Francis CY - London ER - TY - JOUR A1 - Horbach, Andreas A1 - Duong, Minh Tuan A1 - Staat, Manfred T1 - Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement JF - Journal of the mechanical behavior of biomedical materials Y1 - 2017 U6 - https://doi.org/10.1016/j.jmbbm.2017.06.012 SN - 1751-6161 VL - 74 SP - 400 EP - 410 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Richter, Charlotte A1 - Braunstein, Bjoern A1 - Stäudle, Benjamin A1 - Attias, Julia A1 - Suess, Alexander A1 - Weber, Tobias A1 - Mileva, Katja N. A1 - Rittweger, Joern A1 - Green, David A. A1 - Albracht, Kirsten T1 - Gastrocnemius medialis contractile behavior is preserved during 30% body weight supported gait training JF - Frontiers in Sports and Active Living N2 - Rehabilitative body weight supported gait training aims at restoring walking function as a key element in activities of daily living. Studies demonstrated reductions in muscle and joint forces, while kinematic gait patterns appear to be preserved with up to 30% weight support. However, the influence of body weight support on muscle architecture, with respect to fascicle and series elastic element behavior is unknown, despite this having potential clinical implications for gait retraining. Eight males (31.9 ± 4.7 years) walked at 75% of the speed at which they typically transition to running, with 0% and 30% body weight support on a lower-body positive pressure treadmill. Gastrocnemius medialis fascicle lengths and pennation angles were measured via ultrasonography. Additionally, joint kinematics were analyzed to determine gastrocnemius medialis muscle–tendon unit lengths, consisting of the muscle's contractile and series elastic elements. Series elastic element length was assessed using a muscle–tendon unit model. Depending on whether data were normally distributed, a paired t-test or Wilcoxon signed rank test was performed to determine if body weight supported walking had any effects on joint kinematics and fascicle–series elastic element behavior. Walking with 30% body weight support had no statistically significant effect on joint kinematics and peak series elastic element length. Furthermore, at the time when peak series elastic element length was achieved, and on average across the entire stance phase, muscle–tendon unit length, fascicle length, pennation angle, and fascicle velocity were unchanged with respect to body weight support. In accordance with unchanged gait kinematics, preservation of fascicle–series elastic element behavior was observed during walking with 30% body weight support, which suggests transferability of gait patterns to subsequent unsupported walking. KW - AlterG KW - rehabilitation KW - gait KW - walking KW - ultrasound imaging KW - series elastic element behavior KW - muscle fascicle behavior KW - unloading Y1 - 2021 U6 - https://doi.org/10.3389/fspor.2020.614559 SN - 2624-9367 VL - 2021 IS - 2 PB - Frontiers CY - Lausanne ER - TY - JOUR A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred T1 - Physical response of hyperelastic models for composite materials and soft tissues JF - Asia pacific journal on computational engineering Y1 - 2015 U6 - https://doi.org/10.1186/s40540-015-0015-x SN - 2196-1166 VL - 2 IS - 3 (December 2015) SP - 1 EP - 18 ER - TY - JOUR A1 - Molinnus, Denise A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Katz, Evgeny A1 - Schöning, Michael Josef T1 - Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips JF - Electroanalysis N2 - The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor. Y1 - 2017 U6 - https://doi.org/10.1002/elan.201700208 SN - 1521-4109 VL - 29 IS - 8 SP - 1840 EP - 1849 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Christiaens, P. A1 - Williams, O. A. A1 - Wagner, P. A1 - Haenen, K. T1 - Feldeffektsensor auf nanokristalliner Diamantbasis JF - Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. März 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik Y1 - 2008 SN - 978-3-18-092011-5 N1 - VDI-Berichte ; 2011 ; Sensoren und Messsysteme 2008, 14. GMA/ITG-Fachtagung, VDI/VDE- Gesellschaft Mess- und Automatisierungstechnik, + CD-ROM, Ludwigsburg, DE, 11.-12. Mar, 2008 SP - 549 EP - 558 PB - VDI-Verl. CY - Düsseldorf ER - TY - JOUR A1 - Kloock, Joachim P. A1 - Poghossian, Arshak A1 - Schumacher, K. A1 - Rosenkranz, C. A1 - Schultze, J. W. A1 - Müller-Veggian, Mattea A1 - Schöning, Michael Josef T1 - Funktionsprüfung und Charakterisierung von ionensensitiven Feldeffekttransistoren (ISFETs) auf Waferebene mittels Mikrotropfenzelle für den zukünftigen Einsatz in der Sensorproduktion JF - Sensoren und Messsysteme 2006 : Vorträge der 13. ITG/GMA-Fachtagung vom 13. bis 14. März 2006 in Freiburg/Breisgau / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ; VDE/VDI-Gesellschaft Mess- und Automatisierungstechnik (GMA). Wiss. Tagungsleitung: L. M. Reindl Y1 - 2006 SN - 3-8007-2939-3 N1 - Fachtagung Sensoren und Messsysteme <13, 2006, Freiburg, Breisgau> SP - 257 EP - 260 PB - VDE-Verl. CY - Berlin ER - TY - JOUR A1 - Poghossian, Arshak A1 - Yoshinobu, Tatsuo A1 - Simonis, A. A1 - Ecken, H. A1 - Lüth, Hans A1 - Schöning, Michael Josef T1 - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS? JF - Sensors and Actuators B. 78 (2001), H. 1-3 Y1 - 2001 SN - 0925-4005 SP - 237 EP - 242 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Chemical and biological field-effect sensors for liquids – a status report JF - Handbook of biosensors and biochips / ed. Robert S. Marks ... Bd. 1 Y1 - 2007 SN - 978-0-470-01905-4 SP - 395 EP - 412 PB - Wiley CY - Chichester ER - TY - JOUR A1 - Staat, Manfred A1 - Heitzer, M. T1 - FEM-computation of load carrying capacity of highly loaded passive components by direct methods. Heitzer, M. ; Staat, M. JF - Nuclear Engineering and Design. 193 (1999), H. 3 Y1 - 1999 SN - 0029-5493 SP - 349 EP - 358 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Weil, M. A1 - Cherstvy, A. G. A1 - Schöning, Michael Josef T1 - Electrical monitoring of polyelectrolyte multilayer formation by means of capacitive field-effect devices JF - Analytical and bioanalytical chemistry N2 - The semiconductor field-effect platform represents a powerful tool for detecting the adsorption and binding of charged macromolecules with direct electrical readout. In this work, a capacitive electrolyte–insulator–semiconductor (EIS) field-effect sensor consisting of an Al-p-Si-SiO2 structure has been applied for real-time in situ electrical monitoring of the layer-by-layer formation of polyelectrolyte (PE) multilayers (PEM). The PEMs were deposited directly onto the SiO2 surface without any precursor layer or drying procedures. Anionic poly(sodium 4-styrene sulfonate) and cationic weak polyelectrolyte poly(allylamine hydrochloride) have been chosen as a model system. The effect of the ionic strength of the solution, polyelectrolyte concentration, number and polarity of the PE layers on the characteristics of the PEM-modified EIS sensors have been studied by means of capacitance–voltage and constant-capacitance methods. In addition, the thickness, surface morphology, roughness and wettabilityof the PE mono- and multilayers have been characterised by ellipsometry, atomic force microscopy and water contact-angle methods, respectively. To explain potential oscillations on the gate surface and signal behaviour of the capacitive field-effect EIS sensor modified with a PEM, a simplified electrostatic model that takes into account the reduced electrostatic screening of PE charges by mobile ions within the PEM has been proposed and discussed. Y1 - 2013 U6 - https://doi.org/10.1007/s00216-013-6951-9 SN - 1432-1130 ; 1618-2642 VL - 405 IS - 20 SP - 6425 EP - 6436 PB - Springer CY - Berlin ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - Recent advances in biologically sensitive field-effect transistors (BioFETs) JF - Analyst. 127 (2002) Y1 - 2002 SN - 0003-2654 SP - 1137 EP - 1151 ER - TY - JOUR A1 - Staat, Manfred T1 - Versagenswahrscheinlichkeit der Primärkreisdruckumschließung eines HTR-Moduls zur Prozeßwärmegewinnung unter Störfallbedingungen JF - Jahrestagung Kerntechnik '91 / Kerntechnische Gesellschaft e.V. ; Deutsches Atomforum e.V Y1 - 1991 SP - 123 EP - 126 PB - INFORUM CY - Bonn ER - TY - JOUR A1 - Laack, Walter van T1 - Ohne Geist läuft wenig! Teil 2: Zur Unfreiheit verdammt? Eine etwas andere Sicht der Libet-Experimente JF - Die Drei : Zeitschrift für Anthroposophie in Wissenschaft, Kunst und sozialem Leben. 75 (2005), H. 3 Y1 - 2005 SN - 0012-6063 SP - 25 EP - 35 ER - TY - JOUR A1 - Laack, Walter van T1 - Ohne Geist läuft wenig! Teil 1: Kann aus Neuronen Bewusstsein entstehen? JF - Die Drei : Zeitschrift für Anthroposophie in Wissenschaft, Kunst und sozialem Leben. 75 (2005), H. 2 Y1 - 2005 SN - 0012-6063 SP - 31 EP - 38 ER - TY - JOUR A1 - Laack, Walter van T1 - Elektro- und Ultraschalltherapie JF - Stationäre Naturheilkunde : Handbuch für Klinik und Rehabilitation / André-Michael Beer. [Autoren: Peter Altmeyer ...] Y1 - 2005 SN - 3-437-56890-6 SP - 162 EP - 171 PB - Elsevier, Urban und Fischer CY - München ER - TY - JOUR A1 - Schwabedal, Justus T. C. A1 - Sippel, Daniel A1 - Brandt, Moritz D. A1 - Bialonski, Stephan T1 - Automated Classification of Sleep Stages and EEG Artifacts in Mice with Deep Learning N2 - Sleep scoring is a necessary and time-consuming task in sleep studies. In animal models (such as mice) or in humans, automating this tedious process promises to facilitate long-term studies and to promote sleep biology as a data-driven f ield. We introduce a deep neural network model that is able to predict different states of consciousness (Wake, Non-REM, REM) in mice from EEG and EMG recordings with excellent scoring results for out-of-sample data. Predictions are made on epochs of 4 seconds length, and epochs are classified as artifactfree or not. The model architecture draws on recent advances in deep learning and in convolutional neural networks research. In contrast to previous approaches towards automated sleep scoring, our model does not rely on manually defined features of the data but learns predictive features automatically. We expect deep learning models like ours to become widely applied in different fields, automating many repetitive cognitive tasks that were previously difficult to tackle. Y1 - 2018 U6 - https://doi.org/10.48550/arXiv.1809.08443 ER - TY - JOUR A1 - Knobbe, D.-T. A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Mourzina, Y. T1 - Charakterisierung von kapazitiven EMISSensoren mittels Impedanzspektroskopie, Kapazitäts-Spannungs- und Konstant-Kapazitäts-Messung JF - Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. März 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik Y1 - 2004 SN - 3-18-091829-2 N1 - Auch erschienen als: VDI-Berichte ; 1829 SP - 851 EP - 854 PB - VDI CY - Düsseldorf ER - TY - JOUR A1 - Molinnus, Denise A1 - Bäcker, Matthias A1 - Siegert, Petra A1 - Willenberg, H. A1 - Poghossian, Arshak A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Detection of Adrenaline Based on Substrate Recycling Amplification JF - Procedia Engineering N2 - An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied. Y1 - 2015 U6 - https://doi.org/10.1016/j.proeng.2015.08.708 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 540 EP - 543 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Stulpe, Werner T1 - Self-Adjoint Operator JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 692 EP - 697 PB - Springer CY - Berlin ER - TY - JOUR A1 - Stulpe, Werner T1 - Unitary Operator JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 807 EP - 809 PB - Springer CY - Berlin ER - TY - JOUR A1 - Stulpe, Werner T1 - Projection JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 497 EP - 499 PB - Springer CY - Berlin ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Cherstvy, Andrey G. A1 - Pedraza, Angela M. A1 - Ingebrandt, Sven A1 - Schöning, Michael Josef T1 - Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling JF - Physica Status Solidi (a) N2 - Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface. Y1 - 2012 U6 - https://doi.org/10.1002/pssa.201100710 SN - 1862-6319 VL - 209 SP - 925 EP - 934 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Laack, Walter van T1 - Therefore Fermat is right JF - American journal of humanities and social sciences : AJHSS N2 - It was Fernat's idea to investigate how many numbers would fulfill the equation according to the Pythagorean Theorem if the exponent were increased to random, e.g. to a3 + b3 = c3. His question became therefore: are there two whole numbers the cubes of which add up to the volume of the cube of a third whole number? He posed this same question, of course, for all kinds of higher exponents, so that the equation could be generalized: is there an integral solution for the equation an + bn = cn, if the exponent n is higher than 2? Although in 1993, the English mathematician Andrew Wiles was able to produce an arithmetical proof for Fermat's famous theorem, I will show that there is a simple logical explanation which is also pragmatic and plausible and what is the result of a fundamental alternative idea how our world seems to be constructed. Y1 - 2014 SN - 2329-079X (E-Journal); 2329-0781 (Print) VL - 2 IS - 2 SP - 117 EP - 120 ER - TY - JOUR A1 - Stulpe, Werner T1 - Aspects of the Quantum-Classical Connection Based on Statistical Maps JF - Foundations of Physics Y1 - 2019 U6 - https://doi.org/10.1007/s10701-019-00269-9 VL - 49 IS - 6 SP - 677 EP - 692 PB - Springer CY - Berlin ER - TY - JOUR A1 - Stulpe, Werner T1 - Operator JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 440 EP - 444 PB - Springer CY - Berlin ER - TY - JOUR A1 - Poghossian, Arshak A1 - Wagner, H. A1 - Schöning, Michael Josef T1 - Automatisiertes „wafer level“-Testsystem zur Charakterisierung von siliziumbasierten Chemo- und Biosensoren JF - Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA) Y1 - 2010 SN - 978-3-8007-3260-9 N1 - Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik SP - 89 EP - 92 PB - VDE Verlag CY - Berlin ER - TY - JOUR A1 - Stulpe, Werner A1 - Busch, P. A1 - Hellwig, K.-E. T1 - Classical Representations of Finite-Dimensional Quantum Mechanics. Busch, P.; Hellwig, K.-E.; Stulpe, W. JF - International Journal of Theoretical Physics. 32 (1993), H. 3 Y1 - 1993 SN - 1572-9575 SP - 399 EP - 405 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Krämer, Melina A1 - Abouzar, Maryam H. A1 - Pita, Marcos A1 - Katz, Evgeny A1 - Schöning, Michael Josef T1 - Interfacing of biocomputing systems with silicon chips: Enzyme logic gates based on field-effect devices JF - Procedia Chemistry. 1 (2009), H. 1 Y1 - 2009 SN - 1876-6196 N1 - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23 SP - 682 EP - 685 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Poghossian, Arshak A1 - Geissler, Hanno A1 - Schöning, Michael Josef T1 - Rapid methods and sensors for milk quality monitoring and spoilage detection JF - Biosensors and Bioelectronics Y1 - 2019 U6 - https://doi.org/10.1016/j.bios.2019.04.040 SN - 0956-5663 VL - 140 IS - Article 111272 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Laack, Walter van T1 - Nature is much smarter than expected: the Genetic Code is not degenerate JF - American journal of humanities and social sciences N2 - In any books about genetics it can still today be read that our genetic code is called “degenerate” because it is still believed that 43 = 64 triplets encode the 20 essential amino acids. Indeed we have to assume the inverse law, what means that 34 = 81 exact code positions are really effective for our genetic code and encode the amino acids, compiled to proteins. This very important discovery leads to two completely new results that are limits-overlooking: 1) 34 (=81) genetic code positions mean exactly the same number as there are stable and naturally existing chemical elements in our universe. This famous argument should now lead to some alternative, as well as new fundamental conclusions about our existence. 2) A genetic code positioning system shows that nature is much smarter than expected: mutations are made less dangerous than believed, because they won't be that easily able any more to cause severe damages in the protein-synthesis. This should also lead to some alternative views upon evolution of life. Y1 - 2014 SN - 2329-0781 (Print) ; 2329-079X (Online) VL - Vol. 2 IS - No. 1 SP - 10 EP - 12 ER - TY - JOUR A1 - Vögele, Stefan A1 - Rübbelke, Dirk A1 - Govorukha, Kristina A1 - Grajewski, Matthias T1 - Socio-technical scenarios for energy-intensive industries: the future of steel production in Germany JF - Climatic Change Y1 - 2019 U6 - https://doi.org/10.1007/s10584-019-02366-0 SN - 0165-0009 SP - 1 EP - 16 PB - Springer CY - Berlin ER - TY - JOUR A1 - Poghossian, Arshak A1 - Wagner, Holger A1 - Schöning, Michael Josef T1 - Functional testing and characterisation of (bio-)chemical sensors on wafer level JF - Procedia Chemistry. 1 (2009), H. 1 Y1 - 2009 SN - 1876-6196 N1 - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23 SP - 835 EP - 838 ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Siqueira, José R. Jr. A1 - Oliveira, Osvaldo N. Jr. A1 - Moritz, Werner A1 - Schöning, Michael Josef T1 - Capacitive electrolyte-insulator-semiconductor structures functionalised with a polyelectrolyte/enzyme multilayer: New strategy for enhanced field-effect biosensing JF - Physica Status Solidi (A). 207 (2010), H. 4 Y1 - 2010 SN - 1862-6300 N1 - Special Issue: Engineering of Functional Interfaces EnFI 2009 SP - 884 EP - 890 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Ingebrandt, S. A1 - Offenhäusser, A. A1 - Schöning, Michael Josef T1 - Field-effect devices for detecting cellular signals JF - Seminars in Cell & Developmental Biology. 20 (2009), H. 1 Y1 - 2009 SN - 1096-3634 SP - 41 EP - 48 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Tran, Thanh Ngoc A1 - Staat, Manfred T1 - Shakedown analysis of two dimensional structures by an edge-based smoothed finite element method Y1 - 2010 N1 - ECCM 2010, IV European Conference on Computational Mechanics, Paris, France, May 16-21, 2010. SP - 1 EP - 7 ER - TY - JOUR A1 - Laack, Walter van T1 - Experimentelle Untersuchungen über die Wirksamkeit verschiedener Schienbeinschoner im Fußballsport JF - Zeitschrift für Orthopädie und Ihre Grenzgebiete. 123 (1985), H. 6 Y1 - 1985 SN - 0044-3220 SP - 951 EP - 956 ER - TY - JOUR A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül T1 - The emperor's new body : seeking for a blueprint of limb regeneration in humans JF - Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds. Y1 - 2011 SN - 978-3-642-11864-7 SP - 3 EP - 37 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Leschinger, Tim A1 - Besch, Katharina A1 - Aydin, Cansu A1 - Staat, Manfred A1 - Scaal, Martin A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - Irreparable rotator cuff tears: a biomechanical comparison of superior capsuloligamentous complex reconstruction techniques and an interposition graft technique JF - The Orthopaedic Journal of Sports Medicine Y1 - 2019 U6 - https://doi.org/10.1177/2325967119864590 VL - 7 IS - 8 SP - 1 EP - 5 ER - TY - JOUR A1 - Siqueira, José R. Jr. A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Zucolotto, Valtencir A1 - Oliveira, Osvaldo N. Jr. A1 - Schöning, Michael Josef T1 - Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices JF - Physica status solidi (a). 207 (2010), H. 4 Y1 - 2010 SN - 1862-6300 N1 - Special Issue: Engineering of Functional Interfaces EnFI 2009 SP - 781 EP - 786 ER - TY - JOUR A1 - Näther, Niko A1 - Rolka, David A1 - Poghossian, Arshak A1 - Koudelka-Hep, M. A1 - Schöning, Michael Josef T1 - Two microcell flow-injection analysis (FIA) platforms for capacitive silicon-based field-effect sensors JF - Electrochimica Acta. 51 (2005), H. 5 Y1 - 2005 SN - 0013-4686 U6 - https://doi.org/10.1016/j.electacta.2005.04.066 SP - 924 EP - 929 ER - TY - JOUR A1 - Stulpe, Werner A1 - Bjelakovic, Igor T1 - The Projective Hilbert Space as a Classical Phase Space for Nonrelativistic Quantum Dynamics. Bjelakovic, Igor; Stulpe, Werner JF - International Journal of Theoretical Physics. 44 (2005), H. 11 Y1 - 2005 SN - 1572-9575 SP - 2041 EP - 2049 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Han, Yinhua A1 - Offenhäusser, Andreas A1 - Ingebrandt, Sven T1 - Markierungsfreie DNA-Detektion mit Silizium-Feldeffekt-Sensoren – Messeffekte oder Artefakte? JF - tm - Technisches Messen . 74 (2007), H. 9 Y1 - 2007 SN - 0171-8096 SP - 466 EP - 476 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Cherstvy, A. A1 - Ingebrandt, S. A1 - Offenhäusser, A. A1 - Schöning, Michael Josef T1 - Possibilities and limitations of label-free detection of DNA hybridization with field-effect-based devices JF - Sensors and Actuators B. 111-112 (2005) Y1 - 2005 SN - 0925-4005 N1 - Eurosensors XVIII 2004 — The 18th European Conference on Solid-State Transducers SP - 470 EP - 480 ER - TY - JOUR A1 - Pita, Marcos A1 - Krämer, Melina A1 - Zouh, Jian A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Fernandez, Victor M. A1 - Katz, Evgeny T1 - Optoelectronic Properties of Nanostructured Ensembles Controlled by Biomolecular Logic Systems JF - ACS Nano. 10 (2008), H. 2 Y1 - 2008 SN - 1936-086X SP - 2160 EP - 2166 ER - TY - JOUR A1 - Maggakis-Kelemen, Christina A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility JF - Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1 Y1 - 2005 SP - 324 EP - 326 ER - TY - JOUR A1 - Laack, Walter van A1 - Refisch, A. T1 - Der akute und chronische Schulterschmerz / Refisch, A. ; Laack, W. van JF - Deutsche Zeitschrift für Sportmedizin. 36 (1985), H. 6 Y1 - 1985 SN - 0371-3059 SP - 176 EP - 183 ER - TY - JOUR A1 - Laack, Walter van A1 - Dürselen, L. T1 - Alternative zur dauerhaften Verankerung von Gelenkendoprothesen JF - Zeitschrift für Orthopädie und ihre Grenzgebiete. 123 (1985), H. 4 Y1 - 1985 SN - 0044-3220 SP - 653 ER - TY - JOUR A1 - Laack, Walter van T1 - Untersuchungen über die Druckverteilung durch Schienbeinschoner im Fußballsport JF - Deutsche Zeitschrift für Sportmedizin. 36 (1985), H. 7 Y1 - 1985 SN - 0371-3059 SP - 203 EP - 208 ER - TY - JOUR A1 - Gasparyan, Ferdinand V. A1 - Poghossian, Arshak A1 - Vitusevich, Svetlana A. A1 - Petrychuk, Mykhaylo V. A1 - Sydoruk, Viktor A. A1 - Siqueira, José R. Jr. A1 - Oliveira, Osvaldo N. Jr. A1 - Offenhäusser, Andreas A1 - Schöning, Michael Josef T1 - Low-Frequency Noise in Field-Effect Devices Functionalized With Dendrimer/Carbon-Nanotube Multilayers JF - IEEE Sensors Journal. 11 (2011), H. 1 Y1 - 2011 SN - 1530-437X SP - 142 EP - 149 PB - IEEE CY - New York ER - TY - JOUR A1 - Laack, Walter van T1 - Tennisarm - Ursachen und Behandlung JF - Apotheker-Journal . 9 (1987), H. 2 Y1 - 1987 SN - 0720-1028 SP - 42 ER - TY - JOUR A1 - Digel, Ilya T1 - In-situ biological decontamination of an ice melting probe Y1 - 2010 N1 - 38th COSPAR Scientific Assembly. Held 18-15 July 2010, in Bremen, Germany Abstract unter https://www.cospar-assembly.org/abstractcd/OLD/COSPAR-10/abstracts/data/pdf/abstracts/F36-0013-10.pdf ER - TY - JOUR A1 - Stulpe, Werner A1 - Scholz, Erhard T1 - Hilbert Space / Scholz, Erhard ; Stulpe, Werner JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 291 EP - 295 PB - Springer CY - Berlin ER - TY - JOUR A1 - Stulpe, Werner T1 - Density Operator JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 166 EP - 169 PB - Springer CY - Berlin ER - TY - JOUR A1 - Tran, Ngoc Trinh A1 - Staat, Manfred T1 - Direct plastic structural design under lognormally distributed strength by chance constrained programming JF - Optimization and Engineering N2 - We propose the so-called chance constrained programming model of stochastic programming theory to analyze limit and shakedown loads of structures under random strength with a lognormal distribution. A dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) is used with three-node linear triangular elements. Y1 - 2020 U6 - https://doi.org/10.1007/s11081-019-09437-2 SN - 1573-2924 VL - 21 IS - 1 SP - 131 EP - 157 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Gun, Jenny A1 - Gutkin, Vitaly A1 - Lev, Ovadia A1 - Boyen, Hans-Gerd A1 - Saitner, Marc A1 - Wagner, Patrick A1 - Olieslaeger, Marc D´ A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Tracing gold nanoparticle charge by electrolyte-insulator-semiconductor devices JF - Journal of Physical Chemistry C. 115 (2011), H. 11 Y1 - 2011 SN - 1932-7455 SP - 4439 EP - 4445 PB - American Cemical Society CY - Washington, DC ER - TY - JOUR A1 - Gun, Jenny A1 - Rizkov, Dan A1 - Lev, Ovadia A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Oxygen plasma-treated gold nanoparticle-based field-effect devices as transducer structures for bio-chemical sensing JF - Microchimica Acta. 164 (2008), H. 3-4 Y1 - 2008 SN - 1436-5073 SP - 395 EP - 404 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Flow-velocity microsensors based on semiconductor field-effect structures JF - Sensors. 3 (2003), H. 7 Y1 - 2003 SN - 1424-8220 SP - 202 EP - 212 ER - TY - JOUR A1 - Digel, Ilya A1 - Demirci, Taylan A1 - Temiz Artmann, Aysegül A1 - Nishikawa, K. T1 - Free Radical Nature of the Bactericidal Effect of Plasma-Generated Cluster Ions (PCIs) JF - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2 Y1 - 2004 SN - 0932-4666 SP - 982 EP - 983 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Abouzar, Maryam H. A1 - Christiaens, P. A1 - Williams, O. A. A1 - Haenen, K. A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Sensing charged macromolecules with nanocrystalline diamond-based field-effect capacitive sensors JF - Journal of Contemporary Physics. 43 (2008), H. 2 Y1 - 2008 SN - 1934-9378 N1 - Armenian Academy of Sciences SP - 77 EP - 81 ER - TY - JOUR A1 - Ingebrandt, S. A1 - Han, Y. A1 - Nakamura, F. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Offenhäusser, A. T1 - Label-free detection of single nucleotide polymorphisms utilizing the differential transfer function of field-effect transistors JF - Biosensors and Bioelectronics. 22 (2007), H. 12 Y1 - 2007 SN - 0956-5663 SP - 2834 EP - 2840 ER - TY - JOUR A1 - Bronder, Thomas A1 - Wu, Chunsheng A1 - Poghossian, Arshak A1 - Werner, Frederik A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Label-free detection of DNA hybridization with light-addressable potentiometric sensors: comparison of various DNA-immobilization strategies JF - Procedia Engineering N2 - Light-addressable potentiometric sensors (LAPS) consisting of a p-Si-SiO2 and p-Si-SiO2-Au structure, respectively, have been tested for a label-free electrical detection of DNA (deoxyribonucleic acid) hybridization. Three different strategies for immobilizing single-stranded probe DNA (ssDNA) molecules on a LAPS surface have been studied and compared: (a) immobilization of thiol-modified ssDNA on the patterned Au surface via gold-thiol bond, (b) covalent immobilization of amino-modified ssDNA onto the SiO2 surface functionalized with 3-aminopropyltriethoxysilane and (c) layer-by-layer adsorption of negatively charged ssDNA on a positively charged weak polyelectrolyte layer of poly(allylamine hydrochloride). KW - LAPS KW - lable-free detection KW - DNA hybridization KW - field-effect sensor Y1 - 2014 U6 - https://doi.org/10.1016/j.proeng.2014.11.647 SN - 1877-7058 N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014> VL - 87 SP - 755 EP - 758 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Katz, Evgeny A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics JF - Analytical and Bioanalytical Chemistry N2 - The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a “filter” system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion. Y1 - 2017 U6 - https://doi.org/10.1007/s00216-016-0079-7 SN - 1618-2650 VL - 409 SP - 81 EP - 94 PB - Springer CY - Berlin ER - TY - JOUR A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Capacitive field-effect eis chemical sensors and biosensors: A status report JF - Sensors N2 - Electrolyte-insulator-semiconductor (EIS) field-effect sensors belong to a new generation of electronic chips for biochemical sensing, enabling a direct electronic readout. The review gives an overview on recent advances and current trends in the research and development of chemical sensors and biosensors based on the capacitive field-effect EIS structure—the simplest field-effect device, which represents a biochemically sensitive capacitor. Fundamental concepts, physicochemical phenomena underlying the transduction mechanism and application of capacitive EIS sensors for the detection of pH, ion concentrations, and enzymatic reactions, as well as the label-free detection of charged molecules (nucleic acids, proteins, and polyelectrolytes) and nanoparticles, are presented and discussed. Y1 - 2020 U6 - https://doi.org/10.3390/s20195639 SN - 1424-8220 VL - 20 IS - 19 PB - MDPI CY - Basel ER - TY - JOUR A1 - Stulpe, Werner A1 - Bugajski, S. A1 - Hellwig, K.-E. T1 - On Fuzzy Random Variables and Statistical Maps. Bugajski, S.; Hellwig, K.-E.; Stulpe, W. JF - Reports on Mathematical Physics. 41 (1998), H. 1 Y1 - 1998 SN - 0034-4877 SP - 1 EP - 11 ER - TY - JOUR A1 - Staat, Manfred A1 - Heitzer, M. A1 - Hicken, E.F. T1 - LISA, ein europäisches Projekt zur direkten Berechnung der Tragfähigkeit duktiler Strukturen. Y1 - 1998 N1 - PERMAS–Benutzertagung, 8.–9.10.1998, Stuttgart (1998) ER - TY - JOUR A1 - Staat, Manfred T1 - Limit and shakedown analysis under uncertainty JF - Tap chi Khoa hoc & ung dung - Dai hoc Ton Duc Thang Y1 - 2012 N1 - = Journal of Applied Sciences - Ton Duc Thang University VL - 19 SP - 45 EP - 47 ER - TY - JOUR A1 - Molinnus, Denise A1 - Hardt, Gabriel A1 - Siegert, Petra A1 - Willenberg, Holger S. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of Adrenaline in Blood Plasma as Biomarker for Adrenal Venous Sampling JF - Electroanalysis N2 - An amperometric bi-enzyme biosensor based on substrate recycling principle for the amplification of the sensor signal has been developed for the detection of adrenaline in blood. Adrenaline can be used as biomarker verifying successful adrenal venous sampling procedure. The adrenaline biosensor has been realized via modification of a galvanic oxygen sensor with a bi-enzyme membrane combining a genetically modified laccase and a pyrroloquinoline quinone-dependent glucose dehydrogenase. The measurement conditions such as pH value and temperature were optimized to enhance the sensor performance. A high sensitivity and a low detection limit of about 0.5–1 nM adrenaline have been achieved in phosphate buffer at pH 7.4, relevant for measurements in blood samples. The sensitivity of the biosensor to other catecholamines such as noradrenaline, dopamine and dobutamine has been studied. Finally, the sensor has been successfully applied for the detection of adrenaline in human blood plasma. Y1 - 2018 U6 - https://doi.org/10.1002/elan.201800026 SN - 1521-4109 VL - 30 IS - 5 SP - 937 EP - 942 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Poghossian, Arshak A1 - Abouzar, Maryam H. A1 - Christiaens, P. A1 - Williams, O. A. A1 - Haenen, K. A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Nanocrystalline diamond-based field-effect (bio-)chemical sensor JF - 8. Dresdner Sensor-Symposium : Sensoren für Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme für die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung für die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.) Y1 - 2007 SN - 978-3-940046-45-1 N1 - Dresdner Sensor-Symposium <8, 2007, Dresden> ; Dresdner Beiträge zur Sensorik ; 29 SP - 191 EP - 194 PB - TUDpress, Verl. der Wissenschaften CY - Dresden ER - TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, Maximillian A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors JF - Analytical Chemistry N2 - Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers. Y1 - 2015 U6 - https://doi.org/10.1021/acs.analchem.5b00617 SN - 1520-6882 VL - 87 IS - 13 SP - 6607 EP - 6613 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Kramer, Friederike A1 - Halamkova, Lenka A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Katz, Evgeny A1 - Halamek, Jan T1 - Biocatalytic analysis of biomarkers for forensic identification of ethnicity between Caucasian and African American JF - The analyst. August 2013 Y1 - 2013 SN - 1364-5528 (E-Journal); 0003-2654 (Print) VL - Vol. 138 SP - 6251 EP - 6257 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Staat, Manfred T1 - Probabilistische Bewertung des bruchmechanischen Verhaltens der Primärkreisdruckumschließung eines HTR-Moduls Y1 - 1992 N1 - 18. MPA-Seminar : Sicherheit und Verfügbarkeit in der Anlagentechnik mit dem Schwerpunkt Kernenergie. Stuttgart (1992), 27.1-27.18 ER - TY - JOUR A1 - Levers, A. A1 - Staat, Manfred A1 - Laack, Walter van T1 - Analysis of the long-term effect of the MBST® nuclear magnetic resonance therapy on gonarthrosis JF - Orthopedic Practice Y1 - 2016 VL - 47 IS - 11 SP - 521 EP - 528 ER - TY - JOUR A1 - Laack, Walter van T1 - Nahtoderfahrungen aus medizinischer Sicht JF - Deutsche medizinische Wochenschrift : DMW N2 - Nah- versus Nachtoderfahrungen Nahtoderfahrungen (NTE) sind ein Phänomen aus der Kategorie „außergewöhnliche Bewusstseinserfahrungen“. Sie treten in unmittelbarer Nähe des eigenen Todes auf. Oft, aber nicht immer, handelt es sich dabei um Erfahrungen von Personen, die durch ärztliche Maßnahmen wiederbelebt wurden und später davon berichten (NTE-ler). Jedoch kommen solche Phänomene auch bei Menschen vor, die während einer schweren Erkrankung eine lebensbedrohliche Krise haben, hiervon aber spontan genesen. Den NTE ähnlich sind auch sogenannte Nachtod-erfahrungen sowie spontane Erlebnisse, die im Rahmen anderer außergewöhnlicher Stresssituationen auftreten. Von Nachtoderfahrungen spricht man, wenn die Betroffenen anlässlich des Todes von geliebten Angehörigen oder Freunden Erlebnisse haben, die inhaltlich ebenfalls, zumindest aber teilweise, denen von NTE entsprechen. Nachtoderfahrungen sowie spontane NTE-ähnliche Erlebnisse unterscheiden sich jedoch von den echten NTE zumeist sowohl quantitativ als auch qualitativ. Unter einem quantitativen Unterschied versteht man in diesem Zusammenhang eine in der Regel geringer ausgeprägte Komplexität, als sie sehr vielen NTE zu eigen ist. Da sich aber auch viele NTE selbst bezüglich ihrer Komplexität unterscheiden, ist der Hauptunterschied qualitativer Natur: Echte NTE besitzen gegenüber den anderen hier erwähnten Phänomenen eine größere inhaltliche und emotionale Tiefe. Sie begleiten die Betroffenen anschließend ein Leben lang – zumeist mit positiven, in Einzelfällen aber auch mit negativen Folgen, die bis zu einem späteren Suizid reichen können. Die genannten außergewöhnlichen Bewusstseinsphänomene lassen sich in ihrer Gesamtheit bei rund 5 % der Bevölkerung finden. NTE im Speziellen haben hiervon einen durchaus bedeutenden Anteil. Je nach Studie geben zwischen 18 % und 40 % aller Personen, die reanimiert wurden, an, währenddessen eine NTE erlebt zu haben. Dass nicht alle eine solche Erfahrung machen, wird von Kritikern gern dahingehend interpretiert, NTE seien rein physiologischer und keineswegs spiritueller Natur. Jedoch sollte man bedenken, dass im Fall einer rein neurophysiologischen Grundlage von NTE dann bei jedem ein solches Phänomen zu erwarten wäre, so wie beispielsweise auch die Symptome einer Hypoglykämie im Wesentlichen immer dieselben sind. Y1 - 2014 U6 - https://doi.org/10.1055/s-0034-1387363 SN - 1439-4413 (E-Journal); 0012-0472 (Print); 1437-5982 (Print) VL - Jg. 139 IS - H. 51/52 SP - 2651 EP - 2654 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Horstmann, Marie-Therese A1 - Bialonski, Stephan A1 - Noenning, Nina A1 - Mai, Heinke A1 - Prusseit, Jens A1 - Wellmer, Jörg A1 - Hinrichs, Hermann A1 - Lehnertz, Klaus T1 - State dependent properties of epileptic brain networks: Comparative graph–theoretical analyses of simultaneously recorded EEG and MEG JF - Clinical Neurophysiology N2 - Objective To investigate whether functional brain networks of epilepsy patients treated with antiepileptic medication differ from networks of healthy controls even during the seizure-free interval. Methods We applied different rules to construct binary and weighted networks from EEG and MEG data recorded under a resting-state eyes-open and eyes-closed condition from 21 epilepsy patients and 23 healthy controls. The average shortest path length and the clustering coefficient served as global statistical network characteristics. Results Independent on the behavioral condition, epileptic brains exhibited a more regular functional network structure. Similarly, the eyes-closed condition was characterized by a more regular functional network structure in both groups. The amount of network reorganization due to behavioral state changes was similar in both groups. Consistent findings could be achieved for networks derived from EEG but hardly from MEG recordings, and network construction rules had a rather strong impact on our findings. Conclusions Despite the locality of the investigated processes epileptic brain networks differ in their global characteristics from non-epileptic brain networks. Further methodological developments are necessary to improve the characterization of disturbed and normal functional networks. Significance An increased regularity and a diminished modulation capability appear characteristic of epileptic brain networks. Y1 - 2010 U6 - https://doi.org/10.1016/j.clinph.2009.10.013 SN - 1388-2457 VL - 121 IS - 2 SP - 172 EP - 185 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bäcker, Matthias A1 - Rakowski, D. A1 - Poghossian, Arshak A1 - Biselli, Manfred A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis JF - Journal of Biotechnology N2 - A microfluidic chip integrating amperometric enzyme sensors for the detection of glucose, glutamate and glutamine in cell-culture fermentation processes has been developed. The enzymes glucose oxidase, glutamate oxidase and glutaminase were immobilized by means of cross-linking with glutaraldehyde on platinum thin-film electrodes integrated within a microfluidic channel. The biosensor chip was coupled to a flow-injection analysis system for electrochemical characterization of the sensors. The sensors have been characterized in terms of sensitivity, linear working range and detection limit. The sensitivity evaluated from the respective peak areas was 1.47, 3.68 and 0.28 μAs/mM for the glucose, glutamate and glutamine sensor, respectively. The calibration curves were linear up to a concentration of 20 mM glucose and glutamine and up to 10 mM for glutamate. The lower detection limit amounted to be 0.05 mM for the glucose and glutamate sensor, respectively, and 0.1 mM for the glutamine sensor. Experiments in cell-culture medium have demonstrated a good correlation between the glutamate, glutamine and glucose concentrations measured with the chip-based biosensors in a differential-mode and the commercially available instrumentation. The obtained results demonstrate the feasibility of the realized microfluidic biosensor chip for monitoring of bioprocesses. Y1 - 2013 U6 - https://doi.org/10.1016/j.jbiotec.2012.03.014 SN - 0168-1656 VL - 163 IS - 4 SP - 371 EP - 376 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Huck, Christina A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Combined amperometric/field-effect sensor for the detection of dissolved hydrogen JF - Sensors and actuators B: Chemical N2 - Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3% (v/v) with a slope of 198.4 ± 13.7 nA/% (v/v) and 14.9 ± 0.5 mV/% (v/v), respectively. Y1 - 2012 U6 - https://doi.org/10.1016/j.snb.2012.10.050 SN - 0925-4005 N1 - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors" VL - 187 SP - 168 EP - 173 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Poghossian, Arshak A1 - Mai, D.-T. A1 - Mourzina, Y. A1 - Schöning, Michael Josef T1 - Impedance effect of an ion-sensitive membrane: characterisation of an EMIS sensor by impedance spectroscopy, capacitance-voltage and constant-capacitance method JF - Sensors and Actuators B. 103 (2004), H. 1-2 Y1 - 2004 SN - 0925-4005 SP - 423 EP - 428 ER - TY - JOUR A1 - Ullrich, Sebastian A1 - Grottke, Oliver A1 - Rossaint, Rolf A1 - Staat, Manfred A1 - Deserno, Thomas M. A1 - Kuhlen, Torsten T1 - Virtual Needle Simulation with Haptics for Regional Anaesthesia Y1 - 2010 N1 - IEEE Virtual Reality 2010, Workshop on Medical Virtual Environments, Waltham, MA, USA, March 21, 2010 SP - 1 EP - 3 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - Silicon-based field-effect devices with nanostructured surfaces for bio-/chemical sensing JF - Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009 Y1 - 2009 SP - 51 EP - 53 ER - TY - JOUR A1 - Spelthahn, Heiko A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Self-aligned nanogaps and nanochannels via conventional photolithography and pattern-size reduction technique JF - Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI Y1 - 2009 SN - 0013-4686 SP - 6010 EP - 6014 ER - TY - JOUR A1 - Beging, Stefan A1 - Leinhos, Marcel A1 - Jablonski, Melanie A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Studying the spatially resolved immobilisation of enzymes on a capacitive field-effect structure by means of nano-spotting JF - Physica status solidi (a) Y1 - 2015 U6 - https://doi.org/10.1002/pssa.201431891 SN - 1862-6319 VL - 212 IS - 6 SP - 1353 EP - 1358 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Stulpe, Werner A1 - Busch, Paul T1 - The structure of classical extensions of quantum probability theory JF - Journal of Mathematical Physics. 49 (2008), H. 3 Y1 - 2008 SN - 1089-7658 N1 - 032104 SP - 1 EP - 22 ER - TY - JOUR A1 - Bäcker, Matthias A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Degradationsverhalten bioabbaubarer Polymere : siliziumbasierte Sensorik zur Überwachung JF - GIT Labor-Fachzeitschrift Y1 - 2013 SN - 0016-3538 SP - 32 EP - 33 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Thust, M. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Naser, S. A1 - Müller-Veggian, Mattea A1 - Kordos, P. A1 - Lüth, H. T1 - Crosssensitivity of a capacitive penicillin sensor combined with a diffusion barrier JF - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1. Y1 - 1999 SN - 90-76699-02-X N1 - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague) SP - 573 EP - 576 CY - The Hague, The Netherlands ER - TY - JOUR A1 - Laack, Walter van A1 - Refisch, A. A1 - Vogel, P. T1 - Polymyalgia rheumatica vom Beckengürteltyp: Eine seltene Differentialdiagnose der radikulären und pseudoradikulären Lumbalsyndrome. Fallbeschreibung und Literaturübersicht / Refisch, A. ; Laack, W. van ; Vogel, P. JF - Orthopädische Praxis. 23 (1987) Y1 - 1987 SN - 0030-588x SP - 567 ER - TY - JOUR A1 - Laack, Walter van T1 - Physiotherapeutische Behandlung nach Gelenkoperationen JF - Aktuelle Ergebnisse der Osteologie : Timmendorfer Strand, 21. - 23. November 1985 / hrsg. von P. Dietsch Y1 - 1986 SN - 3-11-011147-0 N1 - Osteologia ; 1 PB - de Gruyter CY - Berlin ER - TY - JOUR A1 - Poghossian, Arshak A1 - Jablonski, Melanie A1 - Koch, Claudia A1 - Bronder, Thomas A1 - Rolka, David A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Field-effect biosensor using virus particles as scaffolds for enzyme immobilization JF - Biosensors and Bioelectronics N2 - A field-effect biosensor employing tobacco mosaic virus (TMV) particles as scaffolds for enzyme immobilization is presented. Nanotubular TMV scaffolds allow a dense immobilization of precisely positioned enzymes with retained activity. To demonstrate feasibility of this new strategy, a penicillin sensor has been developed by coupling a penicillinase with virus particles as a model system. The developed field-effect penicillin biosensor consists of an Al-p-Si-SiO₂-Ta₂O₅-TMV structure and has been electrochemically characterized in buffer solutions containing different concentrations of penicillin G. In addition, the morphology of the biosensor surface with virus particles was characterized by scanning electron microscopy and atomic force microscopy methods. The sensors possessed a high penicillin sensitivity of ~ 92 mV/dec in a nearly-linear range from 0.1 mM to 10 mM, and a low detection limit of about 50 µM. The long-term stability of the penicillin biosensor was periodically tested over a time period of about one year without any significant loss of sensitivity. The biosensor has also been successfully applied for penicillin detection in bovine milk samples. Y1 - 2018 U6 - https://doi.org/10.1016/j.bios.2018.03.036 SN - 0956-5663 VL - 110 SP - 168 EP - 174 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bäcker, Matthias A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Multi-Parametererfassung mit siliziumbasiertem Sensorchip: Aus Drei mach Eins JF - GIT Labor-Fachzeitschrift Y1 - 2014 SN - 0016-3538 IS - 2 SP - 28 EP - 30 PB - Wiley ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Schultze, J. W. A1 - Lüth, H. T1 - Field-effect based multifunctional hybrid sensor module for the determination of both (bio-)chemical and physical paramters JF - Proceedings of SPIE. 4576 (2002) Y1 - 2002 SP - 149 EP - 159 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Berndsen, L. A1 - Schöning, Michael Josef T1 - Chemical sensor as a physical sensor: ISFET-based flowvelocity, flow-direction and diffusion-coefficient sensor JF - Book of abstracts / ed. by J. Saneistr. Y1 - 2002 SN - 80-01-02576-4 N1 - Eurosensors ; (16, 2002, Praha) SP - 649 EP - 652 PB - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement CY - Prague ER - TY - JOUR A1 - Näther, Niko A1 - Auger, V. A1 - Poghossian, Arshak A1 - Koudelka-Hep, M. A1 - Schöning, Michael Josef T1 - A miniaturized flow-through cell in SU-8 technique for EIS sensors JF - Biomedizinische Technik. 49 (2004), H. 2 Y1 - 2004 SN - 0932-4666 SP - 994 EP - 995 ER - TY - JOUR A1 - Ciobanu, Octavian A1 - Staat, Manfred A1 - Rahimi, Alireza T1 - The use of open source software in biomechanical finite element analysis JF - Buletinul Institutului Politehnic din Iaşi / Universitatea Tehnică Gh. Asachi, Iaşi Secţia 5, Construcţii de maşini = Machine construction = Bulletin of the Polytechnic Institute of Jassy = Izvestija Jasskogo Politechničeskogo Instituta Y1 - 2008 SN - 1011-2855 VL - 54 IS - 7/8 SP - 213 EP - 220 ER - TY - JOUR A1 - Buniatyan, V. A1 - Huck, Christina A1 - Poghossian, Arshak A1 - Aroutiounian, V. M. A1 - Schöning, Michael Josef T1 - BaxSr1-x TiO3/pc-Si heterojunction capacitance JF - Armenian journal of physics Y1 - 2013 SN - 1829-1171 VL - 6 IS - 4 SP - 188 EP - 197 PB - National Academy of Sciences of Armenia CY - Yerevan ER -