TY - JOUR A1 - Laumann, Jörg A1 - Mainz, Stefan T1 - Direkte Ermittlung der erforderlichen Einspanntiefe von I‑förmigen Stahlquerschnitten in Betonkonstruktionen N2 - Für die Ermittlung der erforderlichen Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen existieren verschiedene Bemessungsmodelle. Diese basieren vorwiegend auf Grundlage nationaler Normen wie z. B. DIN 18800 [1] und DIN 1045 [2], die durch die europäische Normung ersetzt wurden. Aus diesem Grund wird in diesem Aufsatz ein Berechnungsmodell für die erforderliche Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen auf Grundlage des Eurocodes vorgestellt. Das Grundgerüst für dieses Berechnungsmodell bildet das Verfahren nach Kindmann und Laumann, welches in [3] behandelt wurde. Gleichzeitig werden neue Formeln zur direkten Ermittlung der Mindesteinspanntiefe vorgestellt. Behandelt werden gewalzte I-Profile für einachsige Biegung um die starke Achse (y-y) mit Drucknormalkraft. Y1 - 2012 U6 - https://doi.org/10.1002/stab.201201620 SN - 1437-1049 VL - 81 IS - 11 SP - 850 EP - 860 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Meyer-Stork, L. Sebastian A1 - Kalbe, Jochen A1 - Kuropka, Rolf A1 - Sauter, S. L. A1 - Höcker, Hartwig A1 - Berndt, Heinz T1 - Eindeutige Provenienzanalyse von Wolle und feinen Tierhaaren mit Hilfe der Erbsubstanz (DNS) JF - Textilveredlung : schweizerische Zeitschrift für Textilchemie, Textilveredlung und deren Randgebiete Y1 - 1988 SN - 0040-5310 VL - 23 IS - 9 SP - 304 EP - 307 ER - TY - JOUR A1 - Finkenberger, Isabel Maria A1 - Veil, Katja T1 - Räumliche Transformation JF - RaumPlanung : Fachzeitschrift für räumliche Planung und Forschung Y1 - 2020 SN - 0176-7534 VL - 205 IS - 1 SP - 6 EP - 11 PB - IfR (Informationskreis für Raumplanung) CY - Dortmund ER - TY - JOUR A1 - Frohberg, Martin G. A1 - Anik, Sabri T1 - Experimentelle Ergebnisse zum Lösungsverhalten von Sauerstoff in den Systemen Cu-O-Bi und Cu-O-Pb JF - Neue Hütte : metallurgisch-metallkundliche Fachzeitschrift für Forschung und Praxis Y1 - 1986 SN - 0028-3207 VL - 31 IS - 9 SP - 344 EP - 347 ER - TY - JOUR A1 - Anik, Sabri A1 - Topuz, A. A1 - Tuncel, H. S. T1 - Einfluß der Parameter beim Diffusionsschweißen der Stähle X 210 Cr 12 und 25 MoCr 4 auf ihre mechanischen Eigenschaften JF - Schweißen und Schneiden : Fachzeitschrift für Schweißen und verwandte Verfahren Y1 - 1991 SN - 0036-7184 VL - 43 IS - 6 SP - 341 EP - 344 ER - TY - JOUR A1 - Weber, Pascale A1 - Rigling, Andreas A1 - Eilmann, Britta A1 - Mayer, Phillip A1 - Wohlgemuth, Thomas A1 - Dobbertin, Matthias T1 - Verjüngung und Konkurrenz der Flaumeiche im Wallis JF - Informationsblatt Wald Y1 - 2008 SN - 1661-5859 (Online) SN - 1424-5701 (Print) SN - 1661-5832 (Print) IS - 22 SP - 1 EP - 3 ER - TY - JOUR A1 - Eilmann, Britta A1 - Weber, Pascale A1 - Rigling, Andreas A1 - Eckstein, Dieter T1 - Growth reactions of Pinus sylvestris L. and Quercus pubescens Willd. to drought years at a xeric site in Valais, Switzerland JF - Dendrochronologia Y1 - 2006 U6 - https://doi.org/doi:10.1016/j.dendro.2005.10.002 SN - 1612-0051 (Online) SN - 1125-7865 (Print) VL - 23 IS - 3 SP - 121 EP - 132 ER - TY - JOUR A1 - Schnabel, Eugen A1 - Schnabel, Henning A1 - Berndt, Heinz T1 - Zur selektiven acidolytischen Abspaltbarkeit der tert.-Butyloxycarbonyl-Gruppe JF - Justus Liebigs Annalen der Chemie N2 - Die tert.-Butyloxycarbonyl-Gruppe (Boc) läßt sich mittels reiner Trifluoressigsäure nicht selektiv neben dem Benzyloxycarbonyl-Rest (Z) abspalten. Das gelingt auch nicht mit Lösungen von Trifluoressigsäure bzw. Chlorwasserstoff in organischen Lösungsmitteln. Kern-substituierte Z-Gruppen wie Z(pCl), Z(mCl) oder Z(pNO₂) sind zwar stabiler, werden aber von den obengenannten Reagenzien ebenfalls angegriffen bzw. sind nicht mehr acidolytisch abspaltbar. – Mit 70proz. wäßriger Trifluoressigsäure gelingt die Abspaltung von Boc neben Z dagegen fast selektiv; dabei werden aber Benzylester, besonders Glutaminsäure-γ-benzylester, teilweise hydrolysiert, während Methyl- sowie Äthylester nahezu beständig sind. Die Brauchbarkeit des Abspaltungsverfahrens wird anhand der schrittweise durchgeführten Synthese zweier Heptapeptid-Derivate gezeigt. – Ähnlich spezifisch gelingt die Abspaltung von Boc mit Bortrifluorid-ätherat in Eisessig; Benzylester sind gegenüber diesem Reagenz stabiler als gegen wäßrige Trifluoressigsäure. Das Bortrifluorid-Verfahren eignet sich besonders für die Abspaltung von Boc-Gruppen neben säurelabilen Thiol-Schutzgruppen (Tetrahydropyranyl- bzw. Trityl-Rest) sowie neben dem Cyclocystinyl-Rest. Die Leistungsfähigkeit der Methode wird durch die Synthese zweier Peptid-Derivate mit S-Trityl-Schutzgruppen belegt. Als Nebenreaktion ist die Acetylierung von aliphatischen Hydroxylgruppen möglich. Sie läßt sich vermeiden, wenn man die Spaltung in anderen Lösungsmitteln durchführt. Die als Modellverbindungen für Stabilitätsuntersuchungen verwendeten Nε-acylierten Lysin-Derivate werden mit dem Aminosäureanalysator quantitativ neben Lysin bestimmt. Y1 - 1971 U6 - https://doi.org/10.1002/jlac.19717490111 SN - 1099-0690 VL - 749 IS - 1 SP - 90 EP - 108 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kuropka, Rolf A1 - Müller, Bettina A1 - Höcker, Hartwig A1 - Berndt, Heinz T1 - Chiral stationary phases via hydrosilylation reaction of N-acryloylamino acids : I. Stationary phase with one chiral centre for high-performance liquid chromatography and development of a new derivatization pattern for amino acid enantiomers JF - Journal of chromatography A Y1 - 1989 SN - 0021-9673 IS - 481 SP - 380 EP - 386 ER - TY - JOUR A1 - Nokihara, Kiyoshi A1 - Berndt, Heinz T1 - Studies on sulfur-containing peptides : tert-butyloxycarbonylsulfenyl and benzyloxycarbonylsulfenyl derivatives as protecting groups for cysteine JF - The journal of organic chemistry Y1 - 1978 U6 - https://doi.org/10.1021/jo00419a046 SN - 0022-3263 VL - 43 IS - 25 SP - 4893 EP - 4895 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Kalbe, Jochen A1 - Höcker, Hartwig A1 - Berndt, Heinz T1 - Design of enzyme reactors as chromatographic columns for racemic resolution of amino acid esters JF - Chromatographia Y1 - 1989 SN - 0009-5893 U6 - https://doi.org/10.1007/BF02319646 VL - 28 IS - 3-4 SP - 193 EP - 196 ER - TY - JOUR A1 - Peeken, Heinz A1 - Benner, Joachim A1 - Platt, Werner T1 - Ausfallkriterien elastomerbestückter Wellenkupplungen JF - Antriebstechnik : Konstruktion, Entwicklung und Anwendung von Antrieben und Steuerungen ; Organ der Forschungsvereinigung Antriebstechnik e.V. Y1 - 1989 SN - 0341-2652 VL - 28 IS - 11 SP - 85 EP - 88 PB - Vereinigte Fachverl. CY - Mainz ER - TY - JOUR A1 - Ringbeck, Thorsten A1 - Profittlich, Martin A1 - Schaller, Christian T1 - Kameras für die dritte Dimension : PMD-Technologie ermöglicht neue effiziente Anwendungen in der Industrie und Medizintechnik JF - Optik & Photonik. - 4(2009), H. 3 N2 - Fledermäuse orientieren sich extrem schnell auch in absoluter Dunkelheit. Sie verwenden dazu eine Art Ultraschall Radar, um die Umgebung räumlich wahrzunehmen. Der Photo-Misch-Detektor (engl. Photonic Mixer Device, PMD) verwendet dieses Prinzip der Fledermäuse im optischen Bereich — dreidimensionale Szenen werden ohne Rechenaufwand kostengünstig, effizient und mit hoher Geschwindigkeit erfasst. Y1 - 2009 SN - 1863-1460 SP - 30 EP - 33 PB - Wiley - VCH CY - Weinheim ER - TY - JOUR A1 - Fabo, Sabine ED - Prohaska, Steffi T1 - Neue Arten - im Biokosmos des Wahrscheinlichen JF - Neue Arten N2 - Vorwort zu einer Fotoserie, die im Rahmen einer Diplomarbeit (Studierende: Steffi Prohaska, Betreuer: Prof. Wilhelm Schürmann, SS 2008) entstand. KW - Photographie KW - Pflanzen KW - Illusion Y1 - 2008 SP - 4 EP - 7 ER - TY - JOUR A1 - Turck, Christoph W. A1 - Berndt, Heinz T1 - Synthese definierter Peptid-Derivate durch Aminolyse von 3-(Nα-Acyl-peptidyloxy)-2-hydroxy-N-alkylbenzamiden bei erhöhten Temperaturen, I : Synthese des Modellpeptid-Derivates Z-Ala-Phe-Gly-N(Et)2 JF - Hoppe-Seyler´s Zeitschrift für physiologische Chemie Y1 - 1981 U6 - https://doi.org/10.1515/bchm2.1981.362.1.821 SN - 1437-4315 SN - 0018-4888 VL - 362 IS - 1 SP - 821 EP - 828 ER - TY - JOUR A1 - Bragard, Michael A1 - Richter, S. A. T1 - LED-Kreisel als Praxis-Booster JF - Elektor : electronics worldwide Y1 - 2008 SN - 0932-5468 VL - 39 IS - 12 SP - 16 ER - TY - JOUR A1 - Schwarte, Rudolf A1 - Heinol, Horst-Guenther A1 - Buxbaum, Bernd A1 - Xu, Zhanping A1 - Ringbeck, Thorsten A1 - Zhang, Zhigang A1 - Wei, Tai A1 - Hartmann, K. A1 - Kleuver, W. A1 - Luan, Xuming T1 - Neuartige 3D-Visionssysteme auf der Basis Layout-optimierter PMD-Strukturen JF - Technisches Messen : tm ; Plattform für Methoden, Systeme und Anwendungen der Messtechnik ; Organ der AMA (Fachverband für Sensorik e.V.) und der NAMUR (Interessengemeinschaft Prozessleittechnik der Chemischen und Pharmazeutischen Industrie). - 65(1998), H. 7-8 Y1 - 1998 SN - 0340-837X SP - 264 EP - 271 PB - Oldenbourg CY - München ER - TY - JOUR A1 - Porschen, W. A1 - Gartzen, J. A1 - Gewehr, K. A1 - Mühlensiepen, H. A1 - Weber, Hans-Joachim A1 - Feinedegen, L E. T1 - In vivo assay of the radiation sensitivity of hypoxic tumour cells : influence of γ-rays, cyclotron neutrons, misonidazole, hyperthermia and mixed modalities JF - The British journal of cancer / Supplement N2 - Tumour cell death can be evaluated in the living mouse by externally measuring the rate of loss of tumour-bound DNA tracer. By sequentially labelling the tumour-bearing animals with ¹²⁵IUdR and ¹³¹IUdR 50 h apart, the average tumour cells at the time of the second injection are labelled by ¹²⁵IUdR and the euoxic tumour cells are specifically labelled with ¹³¹IUdR. Tumour treatment at this stage of labelling permits the observation of the reaction of euoxic cells and average tumour cells and finally yields data on hypoxic cells and thus on the oxygen enhancement ratio. This information adds to results from tumour control and growth delay. With this technique effects were analysed of 60-Co γ-rays, cyclotron neutrons (E = 6 MeV), misonidazole (500 mg/kg body wt) and hyperthermia (42°C water-bath), or combinations of these. Misonidazole (15 min before irradiation) altered the oxygen enhancement ratio by a factor of 1·5 for γ-rays and of 1·1 for neutrons; when evaluated from tumour-growth delay and TCD-50 misonidazole gave a dose modifying factor of 1·47 for γ-rays and of 1·2-1·3 for neutrons. Based on percentage tumour regression 100 days after treatment, the enhancement ratio from hyperthermia (after irradiation) was 2·75 for γ-rays (at 10 Gray) and 2·2 for neutrons (at 3·2 Gray). For neutrons combined with misonidazole and hyperthermia the ratio was 2·4. These results demonstrate that effects of neutron irradiation may be modified by electron-affinic substances and/or hyperthermia. Y1 - 1978 SN - 0306-9443 N1 - Section 6: Sensitization and Hypoxic Cytotoxicity: Effects of Hyperthermia and High Let IS - 3 SP - 194 EP - 197 PB - Lewis CY - London ER - TY - JOUR A1 - Danho, Waleed A1 - Naithani, Vinod K. A1 - Sasaki, André N. A1 - Föhles, Joseph A1 - Berndt, Heinz A1 - Büllesbach, Erika E. A1 - Zahn, H. T1 - Human proinsulin, VII : synthesis of two protected peptides corresponding to the sequences 1—45 and 46—86 of the prohormone JF - Hoppe-Seyler's Zeitschrift für physiologische Chemie Y1 - 1980 U6 - https://doi.org/10.1515/bchm2.1980.361.1.857 SN - 1437-4315 SN - 0018-4888 VL - 361 IS - 1 SP - 857 EP - 863 ER - TY - JOUR A1 - Kalbe, Jochen A1 - Kuropka, Rolf A1 - Meyer-Stork, L. Sebastian A1 - Berndt, Heinz A1 - Sauter, Sybille L. A1 - Loss, Peter A1 - Hendo, Karsten A1 - Riesner, Detlev A1 - Höcker, Hartwig T1 - Isolation and characterization of high-molecular mass DNA from hair shafts JF - Biological chemistry Y1 - 1988 SN - 0177-3593 U6 - https://doi.org/10.1515/bchm3.1988.369.1.413 VL - 369 IS - 1 SP - 413 EP - 416 ER - TY - JOUR A1 - Kuperjans, Isabel A1 - Starke, M. A1 - Esser, J. A1 - Meyer, J. A1 - Donner, O. T1 - Analyse und Konzeption von Energieanlagen unter ökologischen, wirtschaftlichen und technischen Gesichtspunkten JF - WLB : Umwelttechnik für Industrie und Kommune Y1 - 2000 SN - 0341-2679 VL - 44 IS - 11/12 SP - 26 EP - 29 ER - TY - JOUR A1 - Albanna, Walid A1 - Conzen, Catharina A1 - Weiss, Miriam A1 - Clusmann, Hans A1 - Fuest, Matthias A1 - Mueller, Marguerite A1 - Brockmann, Marc Alexander A1 - Vilser, Walthard A1 - Schmidt-Trucksäss, Arno A1 - Hoellig, Anke A1 - Seiz, Marcel A1 - Thomé, Claudius A1 - Kotliar, Konstantin A1 - Schubert, Gerrit Alexander T1 - Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study JF - PLoS ONE N2 - Background Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. Methods In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2–14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling. Results Image quality was satisfactory in the majority of cases (93.3%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion. Conclusion RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort. Y1 - 2016 U6 - https://doi.org/10.1371/journal.pone.0158781 SN - 1932-6203 VL - 11 IS - 7 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Windmüller, Anna A1 - Schaps, Kristian A1 - Zantis, Frederik A1 - Domgans, Anna A1 - Taklu, Bereket Woldegbreal A1 - Yang, Tingting A1 - Tsai, Chih-Long A1 - Schierholz, Roland A1 - Yu, Shicheng A1 - Kungl, Hans A1 - Tempel, Hermann A1 - Dunin-Borkowski, Rafal E. A1 - Hüning, Felix A1 - Hwang, Bing Joe A1 - Eichel, Rüdiger-A. T1 - Electrochemical activation of LiGaO2: implications for ga-doped garnet solid electrolytes in li-metal batteries JF - ACS Applied Materials & Interfaces N2 - Ga-doped Li7La3Zr2O12 garnet solid electrolytes exhibit the highest Li-ion conductivities among the oxide-type garnet-structured solid electrolytes, but instabilities toward Li metal hamper their practical application. The instabilities have been assigned to direct chemical reactions between LiGaO2 coexisting phases and Li metal by several groups previously. Yet, the understanding of the role of LiGaO2 in the electrochemical cell and its electrochemical properties is still lacking. Here, we are investigating the electrochemical properties of LiGaO2 through electrochemical tests in galvanostatic cells versus Li metal and complementary ex situ studies via confocal Raman microscopy, quantitative phase analysis based on powder X-ray diffraction, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and electron energy loss spectroscopy. The results demonstrate considerable and surprising electrochemical activity, with high reversibility. A three-stage reaction mechanism is derived, including reversible electrochemical reactions that lead to the formation of highly electronically conducting products. The results have considerable implications for the use of Ga-doped Li7La3Zr2O12 electrolytes in all-solid-state Li-metal battery applications and raise the need for advanced materials engineering to realize Ga-doped Li7La3Zr2O12for practical use. KW - LiGaO2 KW - garnet solid electrolyte KW - ga-doping KW - Li7La3Zr2O12 KW - solid-state battery Y1 - 2024 U6 - https://doi.org/10.1021/acsami.4c03729 SN - 39181–3919 VL - 16 IS - 30 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Eichler, Fabian A1 - Balc, Nicolae A1 - Bremen, Sebastian A1 - Nink, Philipp T1 - Investigation of laser powder bed fusion parameters with respect to their influence on the thermal conductivity of 316L samples JF - Journal of Manufacturing and Materials Processing N2 - The thermal conductivity of components manufactured using Laser Powder Bed Fusion (LPBF), also called Selective Laser Melting (SLM), plays an important role in their processing. Not only does a reduced thermal conductivity cause residual stresses during the process, but it also makes subsequent processes such as the welding of LPBF components more difficult. This article uses 316L stainless steel samples to investigate whether and to what extent the thermal conductivity of specimens can be influenced by different LPBF parameters. To this end, samples are set up using different parameters, orientations, and powder conditions and measured by a heat flow meter using stationary analysis. The heat flow meter set-up used in this study achieves good reproducibility and high measurement accuracy, so that comparative measurements between the various LPBF influencing factors to be tested are possible. In summary, the series of measurements show that the residual porosity of the components has the greatest influence on conductivity. The degradation of the powder due to increased recycling also appears to be detectable. The build-up direction shows no detectable effect in the measurement series. KW - Additive manufacturing KW - LPBF KW - SLM KW - Thermal conductivity KW - 316L Y1 - 2024 U6 - https://doi.org/10.3390/jmmp8040166 SN - 2504-4494 N1 - Corresponding author: Fabian Eichler VL - 8 IS - 4 PB - MDPI CY - Basel ER - TY - JOUR A1 - Buck, Raphael A1 - Läubli, Daniel A1 - Meyer, Laura A1 - Moosdorf, Andreas T1 - Re-FRESH! Mit dem Frischesortiment punkten JF - Akzente Y1 - 2013 IS - 3 SP - 36 EP - 43 ER - TY - JOUR A1 - Vahidpour, Farnoosh A1 - Alghazali, Yousef H. M. A1 - Akca, Sevilay A1 - Hommes, Gregor A1 - Schöning, Michael Josef T1 - An Enzyme-Based Interdigitated Electrode-Type Biosensor for Detecting Low Concentrations of H₂O₂ Vapor/Aerosol JF - Chemosensors N2 - This work introduces a novel method for the detection of H₂O₂ vapor/aerosol of low concentrations, which is mainly applied in the sterilization of equipment in medical industry. Interdigitated electrode (IDE) structures have been fabricated by means of microfabrication techniques. A differential setup of IDEs was prepared, containing an active sensor element (active IDE) and a passive sensor element (passive IDE), where the former was immobilized with an enzymatic membrane of horseradish peroxidase that is selective towards H₂O₂. Changes in the IDEs’ capacitance values (active sensor element versus passive sensor element) under H₂O₂ vapor/aerosol atmosphere proved the detection in the concentration range up to 630 ppm with a fast response time (<60 s). The influence of relative humidity was also tested with regard to the sensor signal, showing no cross-sensitivity. The repeatability assessment of the IDE biosensors confirmed their stable capacitive signal in eight subsequent cycles of exposure to H₂O₂ vapor/aerosol. Room-temperature detection of H₂O₂ vapor/aerosol with such miniaturized biosensors will allow a future three-dimensional, flexible mapping of aseptic chambers and help to evaluate sterilization assurance in medical industry. Y1 - 2022 U6 - https://doi.org/10.3390/chemosensors10060202 SN - 2227-9040 N1 - This article belongs to the Special Issue "Bioinspired Chemical Sensors and Micro-Nano Devices" VL - 10 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Baumann, Marcus A1 - Tillmann, Urban A1 - Aletsee, Ludwig T1 - Distribution of Carbon Among Photosynthetic End Products in the Bloom-Forming Arctic Diatom Thalassiosira antarctica COMBER / Tillmann, U. ; Baumann, M.E.M. ; Aletsee, L. JF - Polar Biology. 10 (1989), H. 3 Y1 - 1989 SN - 0722-4060 SP - 231 EP - 238 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Allefeld, Carsten A1 - Wellmer, Jörg A1 - Elger, Christian E. A1 - Lehnertz, Klaus T1 - An approach to identify synchronization clusters within the epileptic network JF - Klinische Neurophysiologie Y1 - 2008 U6 - https://doi.org/10.1055/s-2008-1072881 VL - 39 IS - 1 SP - A79 ER - TY - JOUR A1 - Grinsven, Bart van A1 - Vanden Bon, Natalie A1 - Grieten, Lars A1 - Murib, Mohammed Sharif A1 - Janssen, Stoffel Dominique A1 - Haenen, Ken A1 - Schneider, E. A1 - Ingebrandt, Sven A1 - Schöning, Michael Josef A1 - Vermeeren, Veronique A1 - Ameloot, Marcel A1 - Michiels, Luc A1 - Thoelen, Ronald A1 - De Ceuninck, Ward A. A1 - Wagner, Patrick T1 - Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation JF - Lab on a Chip Y1 - 2011 SN - 1473-0197 VL - 11 IS - 9 SP - 1656 EP - 1663 PB - Royal Society of Chemistry (RSC) CY - Cambridge ER - TY - JOUR A1 - Breitbach, Gerd A1 - Altes, Jürgen A1 - Szimmat, J. T1 - Anwendung der Finite-Element-Methode bei der Berechnung des Wärmetransports durch Strahlung / J. Altes ; G. Breitbach ; J. Szimmat JF - International FEM-Congress : Baden-Baden, Federal Republic of Germany, 17./18. November 1986 Y1 - 1989 N1 - International FEM Congress <15, 1986, Baden-Baden> SP - 127 EP - 148 PB - IKO Software Service GmbH CY - Stuttgart ER - TY - JOUR A1 - Murib, M. S. A1 - Grinsven, B. van A1 - Grieten, L. A1 - Janssens, S. D. A1 - Vermeeren, V. A1 - Eersels, K. A1 - Broeders, J. A1 - Ameloot, Marcel A1 - Michiels, L. A1 - Ceuninck, W. De A1 - Haenen, K. A1 - Schöning, Michael Josef A1 - Wagner, Patrick T1 - Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates JF - Physica Status Solidi (A). Vol. 210 (2013), iss. 5 Y1 - 2013 SN - 0031-8965 SP - 911 EP - 917 PB - Wiley-VCH CY - Berlin ER - TY - JOUR A1 - Murib, M. S. A1 - Yeap, W. S. A1 - Eurlings, Y. A1 - Grinsven, B. van A1 - Boyen, H.-G. A1 - Conings, B. A1 - Michiels, L. A1 - Ameloot, Marcel A1 - Carleer, R. A1 - Warmer, J. A1 - Kaul, P. A1 - Haenen, K. A1 - Schöning, Michael Josef A1 - Ceuninck, W. de A1 - Wagner, P. T1 - Heat-transfer based characterization of DNA on synthetic sapphire chips JF - Sensors and Actuators B: Chemical N2 - In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material. Y1 - 2016 U6 - https://doi.org/10.1016/j.snb.2016.02.027 SN - 0925-4005 VL - 230 IS - 230 SP - 260 EP - 271 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefam T1 - Numerical analysis and implementational aspects of a new multilevel grid deformation method JF - Applied Numerical Mathematics N2 - Recently, we introduced and mathematically analysed a new method for grid deformation (Grajewski et al., 2009) [15] we call basic deformation method (BDM) here. It generalises the method proposed by Liao et al. (Bochev et al., 1996; Cai et al., 2004; Liao and Anderson, 1992) [4], [6], [20]. In this article, we employ the BDM as core of a new multilevel deformation method (MDM) which leads to vast improvements regarding robustness, accuracy and speed. We achieve this by splitting up the deformation process in a sequence of easier subproblems and by exploiting grid hierarchy. Being of optimal asymptotic complexity, we experience speed-ups up to a factor of 15 in our test cases compared to the BDM. This gives our MDM the potential for tackling large grids and time-dependent problems, where possibly the grid must be dynamically deformed once per time step according to the user's needs. Moreover, we elaborate on implementational aspects, in particular efficient grid searching, which is a key ingredient of the BDM. Y1 - 2010 U6 - https://doi.org/10.1016/j.apnum.2010.03.017 SN - 0168-9274 VL - 60 IS - 8 SP - 767 EP - 781 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Stulpe, Werner T1 - From the attempt of certain classical reformulations of quantum mechanics to quasi-probability representations JF - Journal of Mathematical Physics N2 - The concept of an injective affine embedding of the quantum states into a set of classical states, i.e., into the set of the probability measures on some measurable space, as well as its relation to statistically complete observables is revisited, and its limitation in view of a classical reformulation of the statistical scheme of quantum mechanics is discussed. In particular, on the basis of a theorem concerning a non-denseness property of a set of coexistent effects, it is shown that an injective classical embedding of the quantum states cannot be supplemented by an at least approximate classical description of the quantum mechanical effects. As an alternative approach, the concept of quasi-probability representations of quantum mechanics is considered. Y1 - 2014 U6 - https://doi.org/10.1063/1.4861939 SN - 222-488 N1 - bereits unter gleichem Titel aufgenommen bei arxiv : http://arxiv.org/pdf/1307.2314.pdf VL - 55 IS - 1 PB - AIP Publishing CY - College Park, Md. ER - TY - JOUR A1 - Staat, Manfred T1 - Reliability of an HTR-module primary circuit pressure boundary Influences, sensitivity, and comparison with a PWR JF - Nuclear Engineering and Design. 158 (1995), H. 2-3 Y1 - 1995 SN - 0029-5493 SP - 333 EP - 340 ER - TY - JOUR A1 - Heuermann, Holger T1 - Calibration procedures with series impedances and unknown lines simplify on-wafer measurements JF - IEEE transactions on microwave theory and techniques : MTT ; a publication of the IEEE Microwave Theory and Techniques Society. 47 (1999), H. 1 Y1 - 1999 SN - 0018-9480 SP - 1 EP - 5 ER - TY - JOUR A1 - Heuermann, Holger A1 - Schiek, B. T1 - Error corrected impedance measurements with a network analyzer JF - IEEE transactions on instrumentation and measurement : IM / Institute of Electrical and Electronics Engineers, Instrumentation and Measurement Group. 44 (1995), H. 2 Y1 - 1995 SN - 0018-9456 SP - 295 EP - 299 ER - TY - JOUR A1 - Stulpe, Werner T1 - Some Remarks on Classical Representations of Quantum Mechanics JF - Foundations of Physics . 24 (1994), H. 7 Y1 - 1994 SN - 1572-9516 SP - 1089 EP - 1094 ER - TY - JOUR A1 - Kuhnert, Marie-Therese A1 - Bialonski, Stephan A1 - Noenning, Nina A1 - Mai, Heinke A1 - Hinrichs, Hermann A1 - Helmstaedter, Christoph A1 - Lehnertz, Klaus T1 - Incidental and intentional learning of verbal episodic material differentially modifies functional brain networks JF - Plos one N2 - Learning- and memory-related processes are thought to result from dynamic interactions in large-scale brain networks that include lateral and mesial structures of the temporal lobes. We investigate the impact of incidental and intentional learning of verbal episodic material on functional brain networks that we derive from scalp-EEG recorded continuously from 33 subjects during a neuropsychological test schedule. Analyzing the networks' global statistical properties we observe that intentional but not incidental learning leads to a significantly increased clustering coefficient, and the average shortest path length remains unaffected. Moreover, network modifications correlate with subsequent recall performance: the more pronounced the modifications of the clustering coefficient, the higher the recall performance. Our findings provide novel insights into the relationship between topological aspects of functional brain networks and higher cognitive functions. Y1 - 2013 U6 - https://doi.org/10.1371/journal.pone.0080273 VL - 8 IS - 11 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Wolf, Martin R. A1 - Simon, S. A1 - Schlick, Christopher T1 - Qualitative and Quantitative Analysis of Cooperation / Wolf, M. ; Simon, S. ; Schlick, C. JF - Proceedings : May 26 - 29, 1998, Cannes (France) = Actes : 26 - 29 mai 1998 / INRIA, Institut National de Recherche en Informatique et en Automatique, Unité de recherche ... F. Darses ..., eds Y1 - 1998 N1 - COOP ; Institut National de Recherche en Informatique et en Automatique ; Centre ; (Sophia Antipolis) ; International Conference on the Design of Cooperative Systems ; (3 ; 1998.05.26-29 ; Cannes) ; Conference Internationale sur la Conception de Systèmes Coopératifs ; (3 ; 1998.05.26-29 ; Cannes) ; COOP ; (3 ; 1998.05.26-29 ; Cannes) SP - 1 EP - 5 PB - - CY - Cannes ER - TY - JOUR A1 - Laack, Walter van T1 - Ist der Tod das Ende? In: Sterben - wie fühlt sich das an / Ines Elsenhans JF - Via medici : Fachmagazin für junge Mediziner Y1 - 2013 SN - 0949-2488 VL - Vol. 18 IS - Ausg. 5 SP - 38 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Ritz, Thomas T1 - Personalized Information Services: Production and Distribution of these Services employing Mass-Customization Y1 - 2002 N1 - International Congress on Mass Media and Communications in the e-society of the 21st Century, Moskau, 17.-19.10.2002 ER - TY - JOUR A1 - Al-Kaidy, Huschyar A1 - Duwe, Anna A1 - Huster, Manuel A1 - Muffler, Kai A1 - Schlegel, Christin A1 - Sieker, Tim A1 - Stadtmüller, Ralf A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Biotechnologie und Bioverfahrenstechnik – Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen JF - Chemie Ingenieur Technik N2 - Biotechnologie und die mit ihr verbundenen technischen Prozesse prägen seit Jahrtausenden die Entwicklung der Menschheit. Ausgehend von empirischen Verfahren, insbesondere zur Herstellung von Lebensmitteln und täglichen Gebrauchsgütern, haben sich diese Disziplinen zu einem der innovativsten Zukunftsfelder entwickelt. Durch das immer detailliertere Verständnis zellulärer Vorgänge können mittlerweile Produktionsstämme gezielt optimiert werden. Im Zusammenspiel mit moderner Prozesstechnik können so eine Vielzahl von Bulk- und Feinchemikalien sowie Pharmazeutika effizient hergestellt werden. In diesem Artikel werden exemplarisch einige der aktuellen Trends vorgestellt. Y1 - 2014 U6 - https://doi.org/10.1002/cite.201400083 SN - 0009-286X VL - 86 IS - 12 SP - 2215 EP - 2225 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Unden, G. A1 - Becker, S. A1 - Bongaerts, Johannes A1 - Schirawski, J. A1 - Six, S. T1 - Oxygen regulated gene expression in facultatively anaerobic bacteria JF - Antonie van Leeuwenhoek Y1 - 1994 SN - 0003-6072 (Print) ; 1572-9699 (online) VL - Vol. 66 IS - Iss. 1-3 SP - 3 EP - 22 ER - TY - JOUR A1 - Dachwald, Bernd A1 - Tsinas, L. T1 - A combined neural and genetic learning algorithm / Tsinas, L. ; Dachwald, B. JF - Proceedings of the First IEEE Conference on Evolutionary Computation, 1994. IEEE World Congress on Computational Intelligence. Y1 - 1994 SN - 0-7803-1899-4 SP - 770 EP - 774 CY - Orlando, Fl ER - TY - JOUR A1 - Heuermann, Holger A1 - Schiek, Burkhard T1 - Robuster Algorithmus zur Streuparameterbestimmung für systemfehlerkorrigierte Netzwerkanalysatoren JF - Kleinheubacher Berichte : Vorträge und Berichte der gemeinsamen Tagung des U.R.S.I.-Landesausschusses in der Bundesrepublik Deutschland / Hrsg.: Deutsche Telekom AG. 35. 1991 (1991) Y1 - 1991 SP - 555 EP - 556 ER - TY - JOUR A1 - Laack, Walter van A1 - Albrecht, T. T1 - Ultraschalltherapie in der Praxis JF - ZFA - Zeitschrift für Allgemeinmedizin Y1 - 1987 SN - 0341-9835 VL - 63 IS - 19 SP - 605 EP - 608 ER - TY - JOUR A1 - Fabo, Sabine T1 - Exhibition review: Documenta X and its media concept JF - Leonardo Y1 - 1998 SN - 0024-094x N1 - Documenta <10, 1997, Kassel> VL - 31 IS - 4 SP - 330 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Wendler, Martin A1 - Lehnertz, Klaus T1 - Unraveling spurious properties of interaction networks with tailored random networks JF - Plos one N2 - We investigate interaction networks that we derive from multivariate time series with methods frequently employed in diverse scientific fields such as biology, quantitative finance, physics, earth and climate sciences, and the neurosciences. Mimicking experimental situations, we generate time series with finite length and varying frequency content but from independent stochastic processes. Using the correlation coefficient and the maximum cross-correlation, we estimate interdependencies between these time series. With clustering coefficient and average shortest path length, we observe unweighted interaction networks, derived via thresholding the values of interdependence, to possess non-trivial topologies as compared to Erdös-Rényi networks, which would indicate small-world characteristics. These topologies reflect the mostly unavoidable finiteness of the data, which limits the reliability of typically used estimators of signal interdependence. We propose random networks that are tailored to the way interaction networks are derived from empirical data. Through an exemplary investigation of multichannel electroencephalographic recordings of epileptic seizures – known for their complex spatial and temporal dynamics – we show that such random networks help to distinguish network properties of interdependence structures related to seizure dynamics from those spuriously induced by the applied methods of analysis. Y1 - 2011 U6 - https://doi.org/10.1371/journal.pone.0022826 VL - 6 IS - 8 PB - Plos CY - San Francisco ER - TY - JOUR A1 - Golland, Alexander ED - Hoeren, Thomas ED - Schneider, Jochen ED - Selmayr, Martin ED - Spies, Axel ED - Wybitul, Tim T1 - Die „private“ Datenverarbeitung im Internet. Verantwortlichkeiten und Rechtmäßigkeit bei Nutzung von Plattformdiensten durch natürliche Personen JF - ZD Zeitschrift für Datenschutz Y1 - 2020 SN - 2192-5593 VL - 10 IS - 8 SP - 397 EP - 403 PB - Beck CY - München ER - TY - JOUR A1 - Warerkar, Shashikant A1 - Schmitz, Stefan A1 - Göttsche, Joachim A1 - Hoffschmidt, Bernhard T1 - Wirtschaftlich und flexibel : Luft-Sand-Wärmeübertrager für die Energiespeicherung bei Temperaturen bis 800 °C JF - Verfahrenstechnik. 41 (2007), H. 4 Y1 - 2007 SN - 0175-5315 N1 - Comsol-Konferenz zur Multiphysik-Simulation <2006, Frankfurt> SP - 72 EP - 73 ER - TY - JOUR A1 - Pasteur, Aline A1 - Tippkötter, Nils A1 - Kampeis, Percy A1 - Ulber, Roland T1 - Optimization of high gradient magnetic separation filter units for the purification of fermentation products JF - IEEE TRANSACTIONS ON MAGNETICS N2 - High gradient magnetic separation (HGMS) has been established since the early 1970s. A more recent application of these systems is the use in bioprocesses. To integrate the HGMS in a fermentation process, it is necessary to optimize the separation matrix with regard to the magnetic separation characteristics and permeability of the non-magnetizable components of the fermentation broth. As part of the work presented here, a combined fluidic and magnetic force finite element model simulation was created using the software COMSOL Multiphysics and compared with separation experiments. Finally, as optimal lattice orientation of the separation matrix, a transversal rhombohedral arrangement was defined. The high suitability of the new filter matrix has been verified by separation experiments. Y1 - 2014 U6 - https://doi.org/10.1109/TMAG.2014.2325535 SN - 0018-9464 N1 - Article Sequence Number: 5000607 INSPEC Accession Number: 14663042 VL - 50 IS - 10 SP - Artikel 5000607 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Golland, Alexander T1 - Umsetzung der Datenschutz-Grundverordnung – Neue Herausforderungen für Unternehmen JF - NWB Rechnungswesen - BBK N2 - Nach einem intensiven politischen Diskurs wurde im vergangenen Jahr die Datenschutz-Grundverordnung (DSGVO) verabschiedet. Die DSGVO ersetzt zum 25.5.2018 die bislang geltende, aus dem Jahre 1995 stammende Datenschutz-Richtlinie 95/46/EG. Die Novellierung des Datenschutzrechts bringt zahlreiche neue Anforderungen mit sich. Unternehmen sind daher gezwungen, sich auf die Änderungen einzustellen, ihre datenschutzrelevanten Prozesse im Hinblick auf die neuen Anforderungen zu überprüfen und bis zum Mai 2018 an der DSGVO auszurichten. Der Beitrag gibt einen kurzen Überblick über die zentralen Aspekte der Datenschutzreform und die damit einhergehenden Herausforderungen für Unternehmen. Y1 - 2018 SN - 0340-9848 IS - 1 SP - 35 EP - 39 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Ansmann, Gerrit A1 - Kantz, Holger T1 - Data-driven prediction and prevention of extreme events in a spatially extended excitable system JF - Physical Review E Y1 - 2015 U6 - https://doi.org/10.1103/PhysRevE.92.042910 SN - 2470-0053 VL - 92 IS - 4 SP - 042910 ER - TY - JOUR A1 - Wolf, Martin R. A1 - Foltz, Christian A1 - Killich, Stephan A1 - Schmidt, Ludger T1 - Task and Information Modeling for Cooperative Work / Foltz, Christian ; Killich, Stephan ; Wolf, Martin ; Schmidt, Ludger ; Luczak, Holger JF - Systems, social and internationalization design aspects of human-computer interaction / ed. by Michael J. Smith, Gavriel Salvendy Vol. 2 Y1 - 2001 SN - 0-8058-3608-X N1 - International Conference on Human Computer Interaction 9, 2001, New Orleans, La. SP - 172 EP - 176 PB - - ER - TY - JOUR A1 - Staat, Manfred T1 - Versagenswahrscheinlichkeit der Primärkreisdruckumschließung eines HTR-Moduls zur Prozeßwärmegewinnung unter Störfallbedingungen bei verschiedenen Versagensmoden Y1 - 1991 N1 - 17. MPA-Seminar : Sicherheit und Verfügbarkeit in der Anlagentechnik mit dem Schwerpunkt Kerntechnik, Stuttgart (1991), 22.1-22.20 ER - TY - JOUR A1 - Golland, Alexander T1 - Anforderungen an Transfer Impact Assessments bei Datentransfers in unsichere Drittländer JF - DSB Datenschutz-Berater Y1 - 2021 SN - 0170-7256 VL - 45 IS - 7-8 SP - 229 EP - 231 PB - DFV Mediengruppe CY - Frankfurt a.M. ER - TY - JOUR A1 - Allefeld, Carsten A1 - Bialonski, Stephan T1 - Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains JF - Physical Review E Y1 - 2007 U6 - https://doi.org/10.1103/PhysRevE.76.066207 SN - 2470-0053 VL - 76 IS - 6 SP - 066207 ER - TY - JOUR A1 - Laack, Walter van T1 - Entstehen und Funktion von Bewusstsein: Immaterielle Einflussnahme JF - Deutsches Ärzteblatt. 97 (2000), H. 9 Y1 - 2000 SN - 0012-1207 SP - A-540 ER - TY - JOUR A1 - Ulber, Roland A1 - Tippkötter, Nils T1 - Nitratfreie Molke JF - Rundschau für Fleischhygiene und Lebensmittelüberwachung Y1 - 2009 IS - 4 SP - 150 EP - 152 ER - TY - JOUR A1 - Heuermann, Holger A1 - Sadeghfam, Arash T1 - Novel balanced inductor for compact differential systems / Sadeghfam, Arash; Heuermann, Holger JF - Conference proceedings : Tuesday 12th, Wednesday 13th and Thursday 14th October, [RAI International Exhibition and Congress Centre, Amsterdam ; part of European Microwave Week 2004] / EuMA, European Microwave Association Y1 - 2004 SN - 1-580-53992-0 N1 - European Microwave Conference ; (34, 2004, Amsterdam) ; European Microwave Week ; (7, 2004, Amsterdam) SP - 709 EP - 712 PB - Horizon House Publ. CY - London ER - TY - JOUR A1 - Laack, Walter van T1 - Juvenile Osteochondronekrosen - Wesen und mögliche Entstehungsursachen JF - Zeitschrift für Allgemeinmedizin ; ZFA. 60 (1984) Y1 - 1984 SN - 0341-9835 SP - 1432 ER - TY - JOUR A1 - Wiesen, Sebastian A1 - Tippkötter, Nils A1 - Muffler, Kai A1 - Suck, Kirstin A1 - Sohling, Ulrich A1 - Ruf, Friedrich A1 - Ulber, Roland T1 - Adsorption of fatty acids to layered double hydroxides in aqueous systems JF - Adsorption N2 - Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L−1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32−. Y1 - 2015 VL - 21 IS - 6-7 SP - 459 EP - 466 PB - Springer CY - Berlin ER - TY - JOUR A1 - Pham, Phu Tinh A1 - Staat, Manfred T1 - An Upper Bound Algorithm for Limit and Shakedown Analysis of Bounded Linearly Kinematic Hardening Structures JF - Limit State of Materials and Structures : Direct Methods 2. Saxcé, Géry de (Hrsg.) Y1 - 2013 SN - 978-94-007-5424-9 SP - 71 EP - 87 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Heuermann, Holger A1 - Schiek, Burkhard T1 - Error Corrected Impedance Measurements with a Network Analyzer Y1 - 1994 N1 - 1994 Conference on Precision Electromagnetic Measurements digest : 27 June - 1 July 1994, Boulder, Colorado, USA / Organized by National Institute of Standards and Technology. Ed. by Edie DeWeese SP - 125 EP - 126 ER - TY - JOUR A1 - Golland, Alexander T1 - Weckruf für deutsche Großunternehmen? – Der neue Entwurf des IT-Sicherheitsgesetz 2.0 JF - K&R Kommunikation & Recht Y1 - 2020 SN - 1434-6354 VL - 23 IS - 7-8 SP - I PB - DFV Mediengruppe CY - Frankfurt a.M. ER - TY - JOUR A1 - Golland, Alexander T1 - Datenschutz durch modulare Zertifizierung: Trusted Cloud-Pilotprojekt bringt neuen Ansatz JF - DSB Datenschutz-Berater Y1 - 2014 SN - 0170-7256 VL - 38 IS - 10 SP - 213 EP - 215 PB - DFV Mediengruppe CY - Frankfurt a.M. ER - TY - JOUR A1 - Fabo, Sabine T1 - Das Museum lebt? Der Diskurs der Vernetzung im virtuellen Kunstraum JF - Zeitenblicke N2 - Kunstwerke sowie ihre Präsentation und Vermittlung werden zunehmend von digitalen Technologien unterstützt. Virtuelle Ausstellungen, Internet-Projekte und komplexe Datenarchive stellen das Kunstwerk in einen medialen Kontext, der weit über das Moment einer technischen Reproduzierbarkeit hinausgeht. Das allgegenwärtige Konzept der Vernetzung dynamisiert Kunst, ihre Rezipienten und Ausstellungsorte. Die Beziehungen zwischen diesen Feldern werden mit Hilfe physiologischer Metaphern definiert und visualisiert. Frühere Speicher und Archive geraten in einen prozessualen Sog, in dem alles fluktuiert, sich kurzweilig verknüpft, auflöst und in permanente Dialoge mit seiner Umgebung tritt - das virtuelle Museum gerät in aktuellen Standortbestimmungen in die definitorische Nähe des Künstlichen Lebens. KW - Elektronische Kunst KW - Netzkunst KW - Museum KW - Museumsorganisation KW - Virtuelles Museum KW - Virtuelle Ausstellung KW - Digitales Museum KW - Vernetzung KW - Elektronische Kunst KW - Virtual Art KW - Virtual Museum KW - Virtual Exhibition KW - Digital Museum KW - Electronic Art Y1 - 2003 VL - 2(2003) IS - 1 ER - TY - JOUR A1 - Staat, Manfred A1 - Vu, Duc Khoi T1 - Limit analysis of flaws in pressurized pipes and cylindrical vessels Part II: Circumferential defects JF - Engineering Fracture Mechanics ; 97(2013), H. 1 N2 - Upper and lower bound theorems of limit analyses have been presented in part I of the paper. Part II starts with the finite element discretization of these theorems and demonstrates how both can be combined in a primal–dual optimization problem. This recently proposed numerical method is used to guide the development of a new class of closed-form limit loads for circumferential defects, which show that only large defects contribute to plastic collapse with a rapid loss of strength with increasing crack sizes. The formulae are compared with primal–dual FEM limit analyses and with burst tests. Even closer predictions are obtained with iterative limit load solutions for the von Mises yield function and for the Tresca yield function. Pressure loading of the faces of interior cracks in thick pipes reduces the collapse load of circumferential defects more than for axial flaws. Axial defects have been treated in part I of the paper. Y1 - 2012 U6 - https://doi.org/10.1016/j.engfracmech.2012.05.017 SN - 0013-7944 VL - 97 SP - 314 EP - 333 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Laack, Walter van A1 - Albrecht, T. T1 - Mikrobiologische Untersuchungen auf Keimfreiheit bei physikalischen Anwendungen JF - Orthopädische Praxis. 23 (1987) Y1 - 1987 SN - 0030-588x SP - 73 ER - TY - JOUR A1 - Dahmann, Peter T1 - Funktionsweise von Hydraulikfiltern JF - Ölhydraulik und Pneumatik. 37 (1993), H. 2 Y1 - 1993 SN - 0341-2660 SP - 118 EP - 122 ER - TY - JOUR A1 - Niemüller, Tim A1 - Ferrein, Alexander A1 - Eckel, Gerhard A1 - Pirro, David A1 - Podbregar, Patrick A1 - Kellner, Tobias A1 - Rath, Christoph A1 - Steinbauer, Gerald T1 - Providing Ground-truth Data for the Nao Robot Platform JF - RoboCup 2010: Robot Soccer World Cup XIV Y1 - 2011 SN - 978-3-642-20217-9 N1 - Lecture Notes in Computer Science ; 6556 SP - 133 EP - 144 PB - Springer CY - Berlin ER - TY - JOUR A1 - Göttsche, Joachim A1 - Hove, T. T1 - Mapping global, diffuse and beam solar radiation over Zimbabwe / T. Hove ; J. Göttsche JF - Renewable energy. 18 (1999), H. 4 Y1 - 1999 SN - 1879-0682 SP - 535 EP - 556 ER - TY - JOUR A1 - Stulpe, Werner A1 - Ruch, Ernst T1 - Proof of the Mixing Theorem for Statistical Systems in Classical Physics. Ruch, Ernst; Stulpe, Werner JF - Acta Applicandae Mathematicae. 53 (1998), H. 3 Y1 - 1998 SN - 1572-9036 SP - 329 EP - 352 ER - TY - JOUR A1 - Laack, Walter van A1 - Refisch, A. T1 - Beeinflussen Beinhalter die Knieseitenbandstabilität bei der Arthroskopie? JF - Orthopädische Praxis. 23 (1987) Y1 - 1987 SN - 0030-588x SP - 434 ER - TY - JOUR A1 - Göttsche, Joachim T1 - Eldorado summer schools JF - Progress in solar energy education. 3 (1994) Y1 - 1994 SN - 1018-5607 SP - 31 EP - 33 ER - TY - JOUR A1 - Golland, Alexander T1 - Das 2. Datenschutz-Anpassungs- und Umsetzungsgesetz EU Änderungen und Herausforderungen für Unternehmen JF - NWB Unternehmensteuern und Bilanzen – StuB N2 - Kurz vor der parlamentarischen Sommerpause hat der Bundestag am 28.6.2019 das 2. Datenschutz-Anpassungs- und Umsetzungsgesetz EU (2. DSAnpUG-EU) beschlossen, der Bundesrat hat diesem Gesetz am 20.9.2019 zugestimmt. Das Artikelgesetz, welches im sog. Omnibusverfahren zahlreiche Gesetze auf Bundesebene ändert, soll zur Vereinheitlichung und Anpassung des Bundesrechts an die seit Mai 2018 geltende Datenschutz-Grundverordnung (DSGVO) beitragen. KW - Datenschutz KW - Datenschutzgrundverordnung Y1 - 2019 SN - 1615-8024 IS - 20 SP - 787 EP - 790 ER - TY - JOUR A1 - Mues genannt Koers, Lucas A1 - Prevost, David A1 - Paulßen, Elisabeth A1 - Hoehr, Cornelia T1 - Density reduction effects on the production of [11C]CO2 in Nb-body targets on a medical cyclotron N2 - Medical isotope production of 11C is commonly performed in gaseous targets. The power deposition of the proton beam during the irradiation decreases the target density due to thermodynamic mixing and can cause an increase of penetration depth and divergence of the proton beam. In order to investigate the difference how the target-body length influences the operation conditions and the production yield, a 12 cm and a 22 cm Nb-target body containing N2/O2 gas were irradiated using a 13 MeV proton cyclotron. It was found that the density reduction has a large influence on the pressure rise during irradiation and the achievable radioactive yield. The saturation activity of [11C]CO2 for the long target (0.083 Ci/μA) is about 10% higher than in the short target geometry (0.075 Ci/μA). Y1 - 2023 U6 - https://doi.org/10.1016/j.apradiso.2023.110911 VL - 199 IS - Art. 110911 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Özsoylu, Dua A1 - Kizildag, Sefa A1 - Schöning, Michael Josef A1 - Wagner, Torsten T1 - Effect of plasma treatment on the sensor properties of a light‐addressable potentiometric sensor (LAPS) JF - physica status solidi a : applications and materials sciences N2 - A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment. Y1 - 2019 U6 - https://doi.org/10.1002/pssa.201900259 SN - 1862-6319 N1 - Corresponding author: Torsten Wagner VL - 216 IS - 20 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Bergs, Michel A1 - Monakhova, Yulia A1 - Diehl, Bernd W. A1 - Konow, Christopher A1 - Völkering, Georg A1 - Pude, Ralf A1 - Schulze, Margit T1 - Lignins isolated via catalyst-free organosolv pulping from Miscanthus x giganteus, M. sinensis, M. robustus and M. nagara: a comparative study JF - Molecules N2 - As a low-input crop, Miscanthus offers numerous advantages that, in addition to agricultural applications, permits its exploitation for energy, fuel, and material production. Depending on the Miscanthus genotype, season, and harvest time as well as plant component (leaf versus stem), correlations between structure and properties of the corresponding isolated lignins differ. Here, a comparative study is presented between lignins isolated from M. x giganteus, M. sinensis, M. robustus and M. nagara using a catalyst-free organosolv pulping process. The lignins from different plant constituents are also compared regarding their similarities and differences regarding monolignol ratio and important linkages. Results showed that the plant genotype has the weakest influence on monolignol content and interunit linkages. In contrast, structural differences are more significant among lignins of different harvest time and/or season. Analyses were performed using fast and simple methods such as nuclear magnetic resonance (NMR) spectroscopy. Data was assigned to four different linkages (A: β-O-4 linkage, B: phenylcoumaran, C: resinol, D: β-unsaturated ester). In conclusion, A content is particularly high in leaf-derived lignins at just under 70% and significantly lower in stem and mixture lignins at around 60% and almost 65%. The second most common linkage pattern is D in all isolated lignins, the proportion of which is also strongly dependent on the crop portion. Both stem and mixture lignins, have a relatively high share of approximately 20% or more (maximum is M. sinensis Sin2 with over 30%). In the leaf-derived lignins, the proportions are significantly lower on average. Stem samples should be chosen if the highest possible lignin content is desired, specifically from the M. x giganteus genotype, which revealed lignin contents up to 27%. Due to the better frost resistance and higher stem stability, M. nagara offers some advantages compared to M. x giganteus. Miscanthus crops are shown to be very attractive lignocellulose feedstock (LCF) for second generation biorefineries and lignin generation in Europe. Y1 - 2021 U6 - https://doi.org/10.3390/molecules26040842 SN - 1420-3049 N1 - Special Issue Lignin – A Natural Resource with Huge Potential https://www.mdpi.com/journal/molecules/special_issues/lignin_natural VL - 26 IS - 4 PB - MDPI CY - Basel ER - TY - JOUR A1 - Burger, René A1 - Rumpf, Jessica A1 - Do, Xuan Tung A1 - Monakhova, Yulia A1 - Diehl, Bernd W. K. A1 - Rehahn, Matthias A1 - Schulze, Margit T1 - Is NMR combined with multivariate regression applicable for the molecular weight determination of randomly cross-linked polymers such as lignin? JF - ACS Omega N2 - The molecular weight properties of lignins are one of the key elements that need to be analyzed for a successful industrial application of these promising biopolymers. In this study, the use of 1H NMR as well as diffusion-ordered spectroscopy (DOSY NMR), combined with multivariate regression methods, was investigated for the determination of the molecular weight (Mw and Mn) and the polydispersity of organosolv lignins (n = 53, Miscanthus x giganteus, Paulownia tomentosa, and Silphium perfoliatum). The suitability of the models was demonstrated by cross validation (CV) as well as by an independent validation set of samples from different biomass origins (beech wood and wheat straw). CV errors of ca. 7–9 and 14–16% were achieved for all parameters with the models from the 1H NMR spectra and the DOSY NMR data, respectively. The prediction errors for the validation samples were in a similar range for the partial least squares model from the 1H NMR data and for a multiple linear regression using the DOSY NMR data. The results indicate the usefulness of NMR measurements combined with multivariate regression methods as a potential alternative to more time-consuming methods such as gel permeation chromatography. Y1 - 2021 U6 - https://doi.org/10.1021/acsomega.1c03574 SN - 2470-1343 VL - 6 IS - 44 SP - 29516 EP - 29524 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Cheenakula, Dheeraja A1 - Paulsen, Svea A1 - Ott, Fabian A1 - Grömping, Markus T1 - Operational window of a deammonifying sludge for mainstream application in a municipal wastewater treatment plant JF - Water and Environment Journal N2 - The present work aimed to study the mainstream feasibility of the deammonifying sludge of side stream of municipal wastewater treatment plant (MWWTP) in Kaster, Germany. For this purpose, the deammonifying sludge available at the side stream was investigated for nitrogen (N) removal with respect to the operational factors temperature (15–30°C), pH value (6.0–8.0) and chemical oxygen demand (COD)/N ratio (≤1.5–6.0). The highest and lowest N-removal rates of 0.13 and 0.045 kg/(m³ d) are achieved at 30 and 15°C, respectively. Different conditions of pH and COD/N ratios in the SBRs of Partial nitritation/anammox (PN/A) significantly influenced both the metabolic processes and associated N-removal rates. The scientific insights gained from the current work signifies the possibility of mainstream PN/A at WWTPs. The current study forms a solid basis of operational window for the upcoming semi-technical trails to be conducted prior to the full-scale mainstream PN/A at WWTP Kaster and WWTPs globally. KW - Anammox KW - Mainstream KW - Nitrogen removal KW - Partial nitritation KW - Wastewater Y1 - 2023 U6 - https://doi.org/10.1111/wej.12898 SN - 1747-6593 N1 - Corresponding author: Dheeraja Cheenakula VL - 38 IS - 1 SP - 59 EP - 70 PB - Wiley CY - Chichester ER - TY - JOUR A1 - Pourshahidi, Ali Mohammad A1 - Engelmann, Ulrich M. A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim T1 - Resolving ambiguities in core size determination of magnetic nanoparticles from magnetic frequency mixing data JF - Journal of Magnetism and Magnetic Materials N2 - Frequency mixing magnetic detection (FMMD) has been widely utilized as a measurement technique in magnetic immunoassays. It can also be used for the characterization and distinction (also known as “colourization”) of different types of magnetic nanoparticles (MNPs) based on their core sizes. In a previous work, it was shown that the large particles contribute most of the FMMD signal. This leads to ambiguities in core size determination from fitting since the contribution of the small-sized particles is almost undetectable among the strong responses from the large ones. In this work, we report on how this ambiguity can be overcome by modelling the signal intensity using the Langevin model in thermodynamic equilibrium including a lognormal core size distribution fL(dc,d0,σ) fitted to experimentally measured FMMD data of immobilized MNPs. For each given median diameter d0, an ambiguous amount of best-fitting pairs of parameters distribution width σ and number of particles Np with R2 > 0.99 are extracted. By determining the samples’ total iron mass, mFe, with inductively coupled plasma optical emission spectrometry (ICP-OES), we are then able to identify the one specific best-fitting pair (σ, Np) one uniquely. With this additional externally measured parameter, we resolved the ambiguity in core size distribution and determined the parameters (d0, σ, Np) directly from FMMD measurements, allowing precise MNPs sample characterization. Y1 - 2022 U6 - https://doi.org/10.1016/j.jmmm.2022.169969 SN - 0304-8853 VL - 563 IS - In progress, Art. No. 169969 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Monakhova, Yulia A1 - Diehl, Bernd W.K. T1 - Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material JF - Journal of Pharmaceutical and Biomedical Analysis N2 - Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed. For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard. The method was successfully validated for its accuracy, reproducibility, and precision. The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %. The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride. A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available. A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs. NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity). KW - NMR spectroscopy KW - Heparin KW - Crude heparin KW - USP KW - Ions Y1 - 2022 U6 - https://doi.org/10.1016/j.jpba.2022.114915 SN - 0731-7085 VL - 219 IS - Article number: 114915 PB - Elsevier CY - New York, NY ER - TY - JOUR A1 - Monakhova, Yulia A1 - Diehl, Bernd W. K. T1 - Simplification of NMR Workflows by Standardization Using 2H Integral of Deuterated Solvent as Applied to Aloe vera Preparations JF - Applied Magnetic Resonance N2 - In this study, a recently proposed NMR standardization approach by 2H integral of deuterated solvent for quantitative multicomponent analysis of complex mixtures is presented. As a proof of principle, the existing NMR routine for the analysis of Aloe vera products was modified. Instead of using absolute integrals of targeted compounds and internal standard (nicotinamide) from 1H-NMR spectra, quantification was performed based on the ratio of a particular 1H-NMR compound integral and 2H-NMR signal of deuterated solvent D2O. Validation characteristics (linearity, repeatability, accuracy) were evaluated and the results showed that the method has the same precision as internal standardization in case of multicomponent screening. Moreover, a dehydration process by freeze drying is not necessary for the new routine. Now, our NMR profiling of A. vera products needs only limited sample preparation and data processing. The new standardization methodology provides an appealing alternative for multicomponent NMR screening. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and is recommended in different application areas (purity determination, forensics, pharmaceutical analysis, etc.). Y1 - 2021 U6 - https://doi.org/10.1007/s00723-021-01393-4 SN - 1613-7507 VL - 52 IS - 11 SP - 1591 EP - 1600 PB - Springer CY - Cham ER - TY - JOUR A1 - Rabehi, Amine A1 - Garlan, Benjamin A1 - Achtsnicht, Stefan A1 - Krause, Hans-Joachim A1 - Offenhäusser, Andreas A1 - Ngo, Kieu A1 - Neveu, Sophie A1 - Graff-Dubois, Stephanie A1 - Kokabi, Hamid T1 - Magnetic detection structure for Lab-on-Chip applications based on the frequency mixing technique JF - Sensors N2 - A magnetic frequency mixing technique with a set of miniaturized planar coils was investigated for use with a completely integrated Lab-on-Chip (LoC) pathogen sensing system. The system allows the detection and quantification of superparamagnetic beads. Additionally, in terms of magnetic nanoparticle characterization ability, the system can be used for immunoassays using the beads as markers. Analytical calculations and simulations for both excitation and pick-up coils are presented; the goal was to investigate the miniaturization of simple and cost-effective planar spiral coils. Following these calculations, a Printed Circuit Board (PCB) prototype was designed, manufactured, and tested for limit of detection, linear response, and validation of theoretical concepts. Using the magnetic frequency mixing technique, a limit of detection of 15 µg/mL of 20 nm core-sized nanoparticles was achieved without any shielding. KW - Lab-on-Chip KW - magnetic sensing KW - frequency mixing KW - superparamagnetic nanoparticles KW - magnetic beads Y1 - 2018 U6 - https://doi.org/10.3390/s18061747 SN - 1424-8220 VL - 18 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Neuendorf, Christian A1 - Faßbender, Tobias A1 - Nölke, Greta A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim A1 - Schröper, Florian T1 - Sensitive and rapid detection of cholera toxin subunit B using magnetic frequency mixing detection JF - Plos One N2 - Cholera is a life-threatening disease caused by the cholera toxin (CT) as produced by some Vibrio cholerae serogroups. In this research we present a method which directly detects the toxin’s B subunit (CTB) in drinking water. For this purpose we performed a magnetic sandwich immunoassay inside a 3D immunofiltration column. We used two different commercially available antibodies to capture CTB and for binding to superparamagnetic beads. ELISA experiments were performed to select the antibody combination. The beads act as labels for the magnetic frequency mixing detection technique. We show that the limit of detection depends on the type of magnetic beads. A nonlinear Hill curve was fitted to the calibration measurements by means of a custom-written python software. We achieved a sensitive and rapid detection of CTB within a broad concentration range from 0.2 ng/ml to more than 700 ng/ml. Y1 - 2019 U6 - https://doi.org/10.1371/journal.pone.0219356 SN - 1932-6203 VL - 14 IS - 7 PB - Plos CY - San Francisco ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Schönenborn, Kristina A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim T1 - Measurement of the magnetophoretic velocity of different superparamagnetic beads JF - Journal of Magnetism and Magnetic Materials N2 - The movement of magnetic beads due to a magnetic field gradient is of great interest in different application fields. In this report we present a technique based on a magnetic tweezers setup to measure the velocity factor of magnetically actuated individual superparamagnetic beads in a fluidic environment. Several beads can be tracked simultaneously in order to gain and improve statistics. Furthermore we show our results for different beads with hydrodynamic diameters between 200 and 1000 nm from diverse manufacturers. These measurement data can, for example, be used to determine design parameters for a magnetic separation system, like maximum flow rate and minimum separation time, or to select suitable beads for fixed experimental requirements. KW - magnetophoretic velocity KW - superparamagnetic bead KW - magnetic tweezers KW - magnetic separation KW - magnetic actuation Y1 - 2019 U6 - https://doi.org/10.1016/j.jmmm.2018.10.066 SN - 0304-8853 VL - 477 IS - 1 SP - 244 EP - 248 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Sildatke, Michael A1 - Karwanni, Hendrik A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - A distributed microservice architecture pattern for the automated generation of information extraction pipelines JF - SN Computer Science N2 - Companies often build their businesses based on product information and therefore try to automate the process of information extraction (IE). Since the information source is usually heterogeneous and non-standardized, classic extract, transform, load techniques reach their limits. Hence, companies must implement the newest findings from research to tackle the challenges of process automation. They require a flexible and robust system that is extendable and ensures the optimal processing of the different document types. This paper provides a distributed microservice architecture pattern that enables the automated generation of IE pipelines. Since their optimal design is individual for each input document, the system ensures the ad-hoc generation of pipelines depending on specific document characteristics at runtime. Furthermore, it introduces the automated quality determination of each available pipeline and controls the integration of new microservices based on their impact on the business value. The introduced system enables fast prototyping of the newest approaches from research and supports companies in automating their IE processes. Based on the automated quality determination, it ensures that the generated pipelines always meet defined business requirements when they come into productive use. KW - Architectural design KW - Model-driven software engineering KW - Software and systems modeling KW - Enterprise information systems KW - Information extraction Y1 - 2023 U6 - https://doi.org/10.1007/s42979-023-02256-4 SN - 2661-8907 N1 - Corresponding authors: Michael Sildatke, Hendrik Karwanni IS - 4, Article number: 833 PB - Springer Singapore CY - Singapore ER - TY - JOUR A1 - Adels, Klaudia A1 - Monakhova, Yulia T1 - Low-field NMR spectroscopic study of e-cigarettes: Is determination of only nicotine and organic carrier solvents possible? JF - Microchemical Journal N2 - Electronic cigarettes (e-cigarettes) have become popular worldwide with the market growing exponentially in some countries. The absence of product standards and safety regulations requires urgent development of analytical methodologies for the holistic control of the growing diversity of such products. An approach based on low-field nuclear magnetic resonance (LF-NMR) at 80 MHz is presented for the simultaneous determination of key parameters: carrier solvents (vegetable glycerine (VG), propylene glycol (PG) and water), total nicotine as well as free-base nicotine fraction. Moreover, qualitative and quantitative determination of fourteen weak organic acids deliberately added to enhance sensory characteristics of e-cigarettes was possible. In most cases these parameters can be rapidly and conveniently determined without using any sample manipulation such as dilution, extraction or derivatization steps. The method was applied for 37 authentic e-cigarettes samples. In particular, eight different organic acids with the content up to 56 mg/mL were detected. Due to its simplicity, the method can be used in routine regulatory control as well as to study release behaviour of nicotine and other e-cigarettes constituents in different products. KW - Electronic cigarettes KW - Low field NMR KW - Carrier solvents KW - Free-base nicotine KW - Weak organic acids Y1 - 2024 U6 - https://doi.org/10.1016/j.microc.2024.110859 SN - 1095-9149 N1 - Corresponding author: Yulia Monakhova VL - 203 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Karschuck, Tobias A1 - Schmidt, Stefan A1 - Achtsnicht, Stefan A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Multiplexing system for automated characterization of a capacitive field-effect sensor array JF - Physica Status Solidi A N2 - In comparison to single-analyte devices, multiplexed systems for a multianalyte detection offer a reduced assay time and sample volume, low cost, and high throughput. Herein, a multiplexing platform for an automated quasi-simultaneous characterization of multiple (up to 16) capacitive field-effect sensors by the capacitive–voltage (C–V) and the constant-capacitance (ConCap) mode is presented. The sensors are mounted in a newly designed multicell arrangement with one common reference electrode and are electrically connected to the impedance analyzer via the base station. A Python script for the automated characterization of the sensors executes the user-defined measurement protocol. The developed multiplexing system is tested for pH measurements and the label-free detection of ligand-stabilized, charged gold nanoparticles. KW - Capacitive field-effect sensor KW - Gold nanoparticles KW - Label-free detection KW - Multicell KW - Multiplexing Y1 - 2023 U6 - https://doi.org/10.1002/pssa.202300265 SN - 1862-6300 (Print) SN - 1862-6319 (Online) N1 - Corresponding author: Michael Josef Schöning VL - 220 IS - 22 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Burger, René A1 - Lindner, Simon A1 - Rumpf, Jessica A1 - Do, Xuan Tung A1 - Diehl, Bernd W.K. A1 - Rehahn, Matthias A1 - Monakhova, Yulia A1 - Schulze, Margit T1 - Benchtop versus high field NMR: Comparable performance found for the molecular weight determination of lignin JF - Journal of Pharmaceutical and Biomedical Analysis N2 - Lignin is a promising renewable biopolymer being investigated worldwide as an environmentally benign substitute of fossil-based aromatic compounds, e.g. for the use as an excipient with antioxidant and antimicrobial properties in drug delivery or even as active compound. For its successful implementation into process streams, a quick, easy, and reliable method is needed for its molecular weight determination. Here we present a method using 1H spectra of benchtop as well as conventional NMR systems in combination with multivariate data analysis, to determine lignin’s molecular weight (Mw and Mn) and polydispersity index (PDI). A set of 36 organosolv lignin samples (from Miscanthus x giganteus, Paulownia tomentosa and Silphium perfoliatum) was used for the calibration and cross validation, and 17 samples were used as external validation set. Validation errors between 5.6% and 12.9% were achieved for all parameters on all NMR devices (43, 60, 500 and 600 MHz). Surprisingly, no significant difference in the performance of the benchtop and high-field devices was found. This facilitates the application of this method for determining lignin’s molecular weight in an industrial environment because of the low maintenance expenditure, small footprint, ruggedness, and low cost of permanent magnet benchtop NMR systems. KW - NMR KW - PLS-regression KW - Molecular weight determination KW - Chemometrics KW - Biomass Y1 - 2022 SN - 0731-7085 U6 - https://doi.org/10.1016/j.jpba.2022.114649 VL - 212 IS - Article number: 114649 PB - Elsevier CY - New York, NY ER - TY - JOUR A1 - Hoffstadt, Kevin A1 - Pohen, Gino D. A1 - Dicke, Max D. A1 - Paulsen, Svea A1 - Krafft, Simone A1 - Zang, Joachim W. A1 - Fonseca-Zang, Warde A. da A1 - Leite, Athaydes A1 - Kuperjans, Isabel T1 - Challenges and prospects of biogas from energy cane as supplement to bioethanol production JF - Agronomy N2 - Innovative breeds of sugar cane yield up to 2.5 times as much organic matter as conventional breeds, resulting in a great potential for biogas production. The use of biogas production as a complementary solution to conventional and second-generation ethanol production in Brazil may increase the energy produced per hectare in the sugarcane sector. Herein, it was demonstrated that through ensiling, energy cane can be conserved for six months; the stored cane can then be fed into a continuous biogas process. This approach is necessary to achieve year-round biogas production at an industrial scale. Batch tests revealed specific biogas potentials between 400 and 600 LN/kgVS for both the ensiled and non-ensiled energy cane, and the specific biogas potential of a continuous biogas process fed with ensiled energy cane was in the same range. Peak biogas losses through ensiling of up to 27% after six months were observed. Finally, compared with second-generation ethanol production using energy cane, the results indicated that biogas production from energy cane may lead to higher energy yields per hectare, with an average energy yield of up to 162 MWh/ha. Finally, the Farm²CBG concept is introduced, showing an approach for decentralized biogas production. Y1 - 2020 U6 - https://doi.org/10.3390/agronomy10060821 SN - 2073-4395 VL - 10 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Pourshahidi, Ali Mohammad A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim T1 - Multiplex detection of different magnetic beads using frequency scanning in magnetic frequency mixing technique JF - Sensors N2 - In modern bioanalytical methods, it is often desired to detect several targets in one sample within one measurement. Immunological methods including those that use superparamagnetic beads are an important group of techniques for these applications. The goal of this work is to investigate the feasibility of simultaneously detecting different superparamagnetic beads acting as markers using the magnetic frequency mixing technique. The frequency of the magnetic excitation field is scanned while the lower driving frequency is kept constant. Due to the particles’ nonlinear magnetization, mixing frequencies are generated. To record their amplitude and phase information, a direct digitization of the pickup-coil’s signal with subsequent Fast Fourier Transformation is performed. By synchronizing both magnetic beads using frequency scanning in magnetic frequency mixing technique magnetic fields, a stable phase information is gained. In this research, it is shown that the amplitude of the dominant mixing component is proportional to the amount of superparamagnetic beads inside a sample. Additionally, it is shown that the phase does not show this behaviour. Excitation frequency scans of different bead types were performed, showing different phases, without correlation to their diverse amplitudes. Two commercially available beads were selected and a determination of their amount in a mixture is performed as a demonstration for multiplex measurements. KW - frequency mixing magnetic detection KW - magnetic sandwich immunoassay KW - multiparametric immunoassays Y1 - 2019 U6 - https://doi.org/10.3390/s19112599 SN - 1424-8220 VL - 19 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Monakhova, Yulia A1 - Soboleva, Polina M. A1 - Fedotova, Elena S. A1 - Musina, Kristina T. A1 - Burmistrova, Natalia A. T1 - Quantum chemical calculations of IR spectra of heparin disaccharide subunits JF - Computational and Theoretical Chemistry N2 - Heparin is a natural polysaccharide, which plays essential role in many biological processes. Alterations in building blocks can modify biological roles of commercial heparin products, due to significant changes in the conformation of the polymer chain. The variability structure of heparin leads to difficulty in quality control using different analytical methods, including infrared (IR) spectroscopy. In this paper molecular modelling of heparin disaccharide subunits was performed using quantum chemistry. The structural and spectral parameters of these disaccharides have been calculated using RHF/6-311G. In addition, over-sulphated chondroitin sulphate disaccharide was studied as one of the most widespread contaminants of heparin. Calculated IR spectra were analyzed with respect to specific structure parameters. IR spectroscopic fingerprint was found to be sensitive to substitution pattern of disaccharide subunits. Vibrational assignments of calculated spectra were correlated with experimental IR spectral bands of native heparin. Chemometrics was used to perform multivariate analysis of simulated spectral data. KW - IR spectroscopy KW - Chemometrics KW - Quantum chemistry KW - Molecular modelling KW - Quality control Y1 - 2022 SN - 2210-271X U6 - https://doi.org/10.1016/j.comptc.2022.113891 VL - 1217 IS - Article number: 113891 PB - Elsevier CY - New York, NY ER - TY - JOUR A1 - Burmistrova, Natalia A. A1 - Soboleva, Polina M. A1 - Monakhova, Yulia T1 - Is infrared spectroscopy combined with multivariate analysis a promising tool for heparin authentication? JF - Journal of Pharmaceutical and Biomedical Analysis N2 - The investigation of the possibility to determine various characteristics of powder heparin (n = 115) was carried out with infrared spectroscopy. The evaluation of heparin samples included several parameters such as purity grade, distributing company, animal source as well as heparin species (i.e. Na-heparin, Ca-heparin, and heparinoids). Multivariate analysis using principal component analysis (PCA), soft independent modelling of class analogy (SIMCA), and partial least squares – discriminant analysis (PLS-DA) were applied for the modelling of spectral data. Different pre-processing methods were applied to IR spectral data; multiplicative scatter correction (MSC) was chosen as the most relevant. Obtained results were confirmed by nuclear magnetic resonance (NMR) spectroscopy. Good predictive ability of this approach demonstrates the potential of IR spectroscopy and chemometrics for screening of heparin quality. This approach, however, is designed as a screening tool and is not considered as a replacement for either of the methods required by USP and FDA. KW - IR spectroscopy KW - Heparin KW - Authenticity KW - Principal component analysis KW - Soft independent modeling of class analogy Y1 - 2021 SN - 0731-7085 U6 - https://doi.org/10.1016/j.jpba.2020.113811 VL - 194 IS - Article number: 113811 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Laack, Walter van T1 - Neurophysiologisch ist das nicht alles zu erklären : Nahtoderfahrungen aus wissenschaftlicher Sicht JF - Der Allgemeinarzt Y1 - 2017 SN - 0172-7249 VL - 38 IS - 1 SP - 4 EP - 7 PB - Universimed Deutschland GmbH CY - Mainz ER - TY - JOUR A1 - Polaczek, Christa A1 - Henn, Gudrun T1 - Gute Vorkenntnisse verkürzen die Studienzeit JF - Mathematikinformation : eine Zeitschrift von Begabtenförderung Mathematik e.V. Y1 - 2008 SN - 1612-9156 VL - 2008 IS - 49 SP - 46 EP - 50 PB - Begabtenförderung Mathematik CY - Neubiberg ER - TY - JOUR A1 - Wendlandt, Tim A1 - Koch, Claudia A1 - Britz, Beate A1 - Liedek, Anke A1 - Schmidt, Nora A1 - Werner, Stefan A1 - Gleba, Yuri A1 - Vahidpour, Farnoosh A1 - Welden, Melanie A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System JF - Viruses N2 - Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes. KW - biosensor KW - horseradish peroxidase (HRP) KW - glucose oxidase (GOx) KW - enzyme cascade KW - turnip vein clearing virus (TVCV) KW - tobacco mosaic virus (TMV) Y1 - 2023 U6 - https://doi.org/doi.org/10.3390/v15091951 SN - 1999-4915 N1 - This article belongs to the Special Issue "Tobamoviruses 2023" VL - 9 IS - 15 PB - MDPI CY - Basel ER - TY - JOUR A1 - Pourshahidi, Ali Mohammad A1 - Achtsnicht, Stefan A1 - Nambipareechee, Mrinal Murali A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim T1 - Multiplex detection of magnetic beads using offset field dependent frequency mixing magnetic detection JF - Sensors N2 - Magnetic immunoassays employing Frequency Mixing Magnetic Detection (FMMD) have recently become increasingly popular for quantitative detection of various analytes. Simultaneous analysis of a sample for two or more targets is desirable in order to reduce the sample amount, save consumables, and save time. We show that different types of magnetic beads can be distinguished according to their frequency mixing response to a two-frequency magnetic excitation at different static magnetic offset fields. We recorded the offset field dependent FMMD response of two different particle types at frequencies ƒ₁ + n⋅ƒ₂, n = 1, 2, 3, 4 with ƒ₁ = 30.8 kHz and ƒ₂ = 63 Hz. Their signals were clearly distinguishable by the locations of the extremes and zeros of their responses. Binary mixtures of the two particle types were prepared with different mixing ratios. The mixture samples were analyzed by determining the best linear combination of the two pure constituents that best resembled the measured signals of the mixtures. Using a quadratic programming algorithm, the mixing ratios could be determined with an accuracy of greater than 14%. If each particle type is functionalized with a different antibody, multiplex detection of two different analytes becomes feasible. KW - colorization KW - multiplex detection KW - frequency mixing magnetic detection KW - magnetic nanoparticles Y1 - 2021 U6 - https://doi.org/10.3390/s21175859 SN - 1424-8220 N1 - This article belongs to the Special Issue "Advanced Nanomaterial-Based Sensors for Biomedical Applications" VL - 21 IS - 17 PB - MDPI CY - Basel ER -