TY - JOUR A1 - Aboulnaga, E. A. A1 - Zou, H. A1 - Selmer, Thorsten A1 - Xian, M. T1 - Development of a plasmid-based, tunable, tolC-derived expression system for application in Cupriavidus necator H16 JF - Journal of Biotechnology N2 - Cupriavidus necator H16 gains increasing attention in microbial research and biotechnological application due to its diverse metabolic features. Here we present a tightly controlled gene expression system for C. necator including the pBBR1-vector that contains hybrid promoters originating from C. necator native tolC-promoter in combination with a synthetic tetO-operator. The expression of the reporter gene from these plasmids relies on the addition of the exogenous inducer doxycycline (dc). The novel expression system offers a combination of advantageous features as; (i) high and dose-dependent recombinant protein production, (ii) tight control with a high dynamic range (On/Off ratio), which makes it applicable for harmful pathways or for toxic protein production, (iii) comparable cheap inducer (doxycycline, dc), (iv) effective at low inducer concentration, that makes it useful for large scale application, (v) rapid, diffusion controlled induction, and (vi) the inducer does not interfere within the cell metabolism. As applications of the expression system in C. necator H16, the growth ability on glycerol was enhanced by constitutively expressing the E. coli glpk gene-encoding for glycerol kinase. Likewise, we used the system to overcome the expression toxicity of mevalonate pathway in C. necator H16. With this system, the mevalonate-genes were successfully introduced in the host and the recombinant strains could produce about 200 mg/l mevalonate. Y1 - 2018 U6 - http://dx.doi.org/10.1016/j.jbiotec.2018.03.007 SN - 0168-1656 VL - 274 SP - 15 EP - 27 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Aboulnaga, E. H. A1 - Pinkenburg, O. A1 - Schiffels, Johannes A1 - El-Refai, A. A1 - Buckel, W. A1 - Selmer, Thorsten T1 - Butyrate production in Escherichia coli: Exploitation of an oxygen tolerant bifurcating butyryl-CoA dehydrogenase/electron transferring flavoprotein complex from Clostridium difficile JF - Journal of bacteriology. June 14, 2013 Y1 - 2013 SN - 1098-5530 (E-Journal) ; 0021-9193 (Print) SP - Epub ahead of print ER - TY - JOUR A1 - Abulnaga, El-Hussiny A1 - Pinkenburg, Olaf A1 - Schiffels, Johannes A1 - E-Refai, Ahmed A1 - Buckel, Wolfgang A1 - Selmer, Thorsten T1 - Effect of an Oxygen-Tolerant Bifurcating Butyryl Coenzyme A Dehydrogenase/Electron-Transferring Flavoprotein Complex from Clostridium difficile on Butyrate Production in Escherichia coli JF - Journal of bacteriology Y1 - 2013 SN - 1098-5530 [E-Journal] SN - 0021-9193 [Print] VL - 195 IS - 16 SP - 3704 EP - 3713 ER - TY - JOUR A1 - Adels, Klaudia A1 - Elbers, Gereon A1 - Diehl, Bernd A1 - Monakhova, Yulia T1 - Multicomponent analysis of dietary supplements containing glucosamine and chondroitin: comparative low- and high-field NMR spectroscopic study JF - Analytical Sciences N2 - With the prevalence of glucosamine- and chondroitin-containing dietary supplements for people with osteoarthritis in the marketplace, it is important to have an accurate and reproducible analytical method for the quantitation of these compounds in finished products. NMR spectroscopic method based both on low- (80 MHz) and high- (500–600 MHz) field NMR instrumentation was established, compared and validated for the determination of chondroitin sulfate and glucosamine in dietary supplements. The proposed method was applied for analysis of 20 different dietary supplements. In the majority of cases, quantification results obtained on the low-field NMR spectrometer are similar to those obtained with high-field 500–600 MHz NMR devices. Validation results in terms of accuracy, precision, reproducibility, limit of detection and recovery demonstrated that the developed method is fit for purpose for the marketed products. The NMR method was extended to the analysis of methylsulfonylmethane, adulterant maltodextrin, acetate and inorganic ions. Low-field NMR can be a quicker and cheaper alternative to more expensive high-field NMR measurements for quality control of the investigated dietary supplements. High-field NMR instrumentation can be more favorable for samples with complex composition due to better resolution, simultaneously giving the possibility of analysis of inorganic species such as potassium and chloride. KW - Glucosamine KW - Chondroitin sulfate KW - Polysaccharides KW - Dietary supplements KW - High-field NMR Y1 - 2023 U6 - http://dx.doi.org/10.1007/s44211-023-00433-2 SN - 1348-2246 (Online) SN - 0910-6340 (Print) N1 - Corresponding author: Yulia Monakhova VL - 2023 PB - Springer Verlag CY - Cham ER - TY - JOUR A1 - Aggarwal, P. A1 - Dhiman, S. A1 - Kumar, G. A1 - Scherer, Ulrich W. A1 - Singla, M. L. A1 - Srivastava, A. T1 - Optical study of poly(ethyleneterephthalate) modified by different ionizing radiation dose JF - Indian Journal of Pure and Applied Physics N2 - Thin films of poly(ethyleneterephthalate) [PET]were exposed to radiation dose ranging from 10 to 30 kGy by using gamma rays in the range 12.8-177.8 MGy using swift light ions of hydrogen. There was no effect of the radiation dose on the optical behaviour of PET as a result of exposure to radiation dose up to 30 kGy brought about by gamma rays but a significant decrease in the optical band gap values was observed when PET was exposed to swift light ions of hydrogen. The data obtained are discussed in terms of optical studies carried out on PET using swift heavy ions. Y1 - 2012 SN - 0019-5596 VL - 50 IS - 2 SP - 129 EP - 132 ER - TY - JOUR A1 - Aggarwal, Prerna A1 - Singh, Virendra A1 - Singh, Arjun A1 - Scherer, Ulrich W. A1 - Singh, Tejvir A1 - Singla, Madan L. A1 - Srivastava, Alok T1 - Physico-chemical transformations in swift heavy ion modified poly(ethyleneterephthalate) JF - Radiation Physics and Chemistry Y1 - 2011 SN - 0969-806X N1 - In Press, Accepted Manuscript SP - 1 EP - 28 PB - Pergamon Press CY - Oxford ER - TY - CHAP A1 - Al-Kaidy, H. A1 - Ulber, R. A1 - Tippkötter, Nils T1 - A platform technology for the automated reaction control in magnetizable micro-fluidic droplets T2 - Biomaterials - made in bioreactors : book of abstracts, May 26 - 28, 2014, Radisson Blu Park Hotel and Conference Dentre, Radebeul, Germany Y1 - 2014 SP - 21 EP - 22 PB - DECHEMA CY - Frankfurt am Main ER - TY - JOUR A1 - Al-Kaidy, Huschyar A1 - Duwe, Anna A1 - Huster, Manuel A1 - Muffler, Kai A1 - Schlegel, Christin A1 - Sieker, Tim A1 - Stadtmüller, Ralf A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Biotechnologie und Bioverfahrenstechnik – Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen JF - Chemie Ingenieur Technik N2 - Biotechnologie und die mit ihr verbundenen technischen Prozesse prägen seit Jahrtausenden die Entwicklung der Menschheit. Ausgehend von empirischen Verfahren, insbesondere zur Herstellung von Lebensmitteln und täglichen Gebrauchsgütern, haben sich diese Disziplinen zu einem der innovativsten Zukunftsfelder entwickelt. Durch das immer detailliertere Verständnis zellulärer Vorgänge können mittlerweile Produktionsstämme gezielt optimiert werden. Im Zusammenspiel mit moderner Prozesstechnik können so eine Vielzahl von Bulk- und Feinchemikalien sowie Pharmazeutika effizient hergestellt werden. In diesem Artikel werden exemplarisch einige der aktuellen Trends vorgestellt. Y1 - 2014 U6 - http://dx.doi.org/10.1002/cite.201400083 SN - 0009-286X VL - 86 IS - 12 SP - 2215 EP - 2225 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Al-Kaidy, Huschyar A1 - Duwe, Anna A1 - Huster, Manuel A1 - Muffler, Kai A1 - Schlegel, Christin A1 - Tim, Sieker A1 - Stadtmüller, Ralf A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Biotechnology and bioprocess engineering – from the first ullmann's article to recent trends JF - ChemBioEng Reviews N2 - For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed. Y1 - 2015 U6 - http://dx.doi.org/10.1002/cben.201500008 VL - 2 IS - 3 SP - 175 EP - 184 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Al-Kaidy, Huschyar A1 - Kuthan, Kai A1 - Hering, Thomas A1 - Tippkötter, Nils T1 - Aqueous droplets used as enzymatic microreactors and their electromagnetic actuation JF - Journal of Visualized Experiments N2 - For the successful implementation of microfluidic reaction systems, such as PCR and electrophoresis, the movement of small liquid volumes is essential. In conventional lab-on-a-chip-platforms, solvents and samples are passed through defined microfluidic channels with complex flow control installations. The droplet actuation platform presented here is a promising alternative. With it, it is possible to move a liquid drop (microreactor) on a planar surface of a reaction platform (lab-in-a-drop). The actuation of microreactors on the hydrophobic surface of the platform is based on the use of magnetic forces acting on the outer shell of the liquid drops which is made of a thin layer of superhydrophobic magnetite particles. The hydrophobic surface of the platform is needed to avoid any contact between the liquid core and the surface to allow a smooth movement of the microreactor. On the platform, one or more microreactors with volumes of 10 µL can be positioned and moved simultaneously. The platform itself consists of a 3 x 3 matrix of electrical double coils which accommodate either neodymium or iron cores. The magnetic field gradients are automatically controlled. By variation of the magnetic field gradients, the microreactors' magnetic hydrophobic shell can be manipulated automatically to move the microreactor or open the shell reversibly. Reactions of substrates and corresponding enzymes can be initiated by merging the microreactors or bringing them into contact with surface immobilized catalysts. Y1 - 2016 U6 - http://dx.doi.org/10.3791/54643 SN - 1940-087X IS - Issue 126 ER - TY - JOUR A1 - Al-Kaidy, Huschyar A1 - Tippkötter, Nils T1 - Superparamagnetic hydrophobic particles as shell material for digital microfluidic droplets and proof-of-principle reaction assessments with immobilized laccase JF - Engineering in Life Sciences N2 - In the field of biotechnology and molecular biology, the use of small liquid volumes has significant advantages. In particular, screening and optimization runs with acceptable amounts of expensive and hardly available catalysts, reagents, or biomolecules are feasible with microfluidic technologies. The presented new microfluidic system is based on the inclusion of small liquid volumes by a protective shell of magnetizable microparticles. Hereby, discrete aqueous microreactor drops with volumes of 1–30 μL can be formed on a simple planar surface. A digital movement and manipulation of the microreactor is performed by overlapping magnetic forces. The magnetic forces are generated by an electrical coil matrix positioned below a glass plate. With the new platform technology, several discrete reaction compartments can be moved simultaneously on one surface. Due to the magnetic fields, the reactors can even be merged to initiate reactions by mixing or positioned above surface-immobilized catalysts and then opened by magnetic force. Comparative synthesis routes of the magnetizable shell particles and superhydrophobic glass slides including their performance and stability with the reaction platform are described. The influence of diffusive mass transport during the catalyzed reaction is discussed by evaluation finite element model of the microreactor. Furthermore, a first model dye reaction of the enzyme laccase has been established. Y1 - 2016 U6 - http://dx.doi.org/10.1002/elsc.201400124 VL - 16 IS - 3 SP - 222 EP - 230 PB - Wiley-VCH CY - Weinheim ER - TY - PAT A1 - Al-Kaidy, Huschyar A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Vorrichtung und Verfahren zur Bestimmung des Kontaktwinkels eines flüssigen oder mit Flüssigkeit gefüllten Körpers [Offenlegungsschrift] N2 - Die vorliegende Erfindung betrifft eine Vorrichtung und ein Verfahren zur Bestimmung des Kontaktwinkels eines flüssigen oder mit Flüssigkeit gefüllten Körpers. Dieser besteht aus einem Träger (1) und einer damit verbundenen, in einem Winkelbereich von mehr als 0° bis maximal 90° neigbaren Ebene (8) mit einer darin ausgebildeten Abrollbahn (9) für den flüssigen oder mit Flüssigkeit gefüllten Körper. An der Ebene (8) sind mehrere Sensoren (11, 12) zur Erfassung der Rolldauer des Körpers entlang der Rollstrecke angeordnet. Erfindungsgemäß ist vorgesehen, dass die Einstellung des Neigungswinkels der Ebene (8) über ein Winkelmessgerät (10) erfolgt, wodurch ein Abrollwinkel erfassbar ist, bei dem der Körper in Bewegung gerät. Aus der Rolldauer, der Rollstrecke und dem Abrollwinkel wird der Kontaktwinkel des Körpers ermittelt. Y1 - 2014 PB - Deutsches Patent- und Markenamt CY - München ER - TY - PAT A1 - Al-Kaidy, Huschyar A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - A system and a method for the implementation of chemical, biological or physical reactions [Europäische Patentanmeldung] N2 - The invention relates to a system for the implementation of chemical, biological or physical reactions, consisting of - one or more magnetic micro-reactors, each comprising a shell made of hydrophobic magnetic nanoparticles encapsulating an aqueous core, - a plane platform comprising a surface to receive the micro-reactors, - a source that generates a magnetic field above or underneath the platform for manipulating the one or more hydrophobic magnetic micro-reactors, or for moving them along the surface of the platform from one position to another position, characterized in that the aqueous core of the one or more magnetic micro-reactors contains a reaction solution or buffer, and wherein the magnetic field generated by the source correlates to a defined position on the surface of the platform. Y1 - 2013 PB - Europäisches Patentamt CY - Den Hague ER - TY - PAT A1 - Al-Kaidy, Huschyar A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Vorrichtung und Verfahren zur Bestimmung des Kontaktwinkels eines Flüssigkörpers mit einer Festkörperoberfläche N2 - Die vorliegende Erfindung betrifft eine Vorrichtung und ein Verfahren zur Bestimmung des Kontaktwinkels eines flüssigen oder mit Flüssigkeit gefüllten Körpers. Dieser besteht aus einem Träger (1) und einer damit verbundenen, in einem Winkelbereich von mehr als 0 ° bis maximal 90 ° neigbaren Ebene (8) mit einer darin ausgebildeten Abrollbahn (9) für den flüssigen oder mit Flüssigkeit gefüllten Körper. An der Ebene (8) sind mehrere Sensoren (11,12) zur Erfassung der Rolldauer des Körpers entlang der Rollstrecke angeordnet. Erfindungsgemäß ist vorgesehen, dass die Einstellung des Neigungswinkels der Ebene (8) über ein Winkelmessgerät (10) erfolgt, wodurch ein Abrollwinkel erfassbar ist, bei dem der Körper in Bewegung gerät. Aus der Rolldauer, der Rollstrecke und dem Abrollwinkel wird der Kontaktwinkel des Körpers ermittelt. Y1 - 2016 N1 - Patent auch unter DE102014000419 und WO2015107159 veröffentlicht. ER - TY - JOUR A1 - Aletsee, Ludwig A1 - Baumann, Marcus T1 - A laboratory incubator equipped with facilities to automatically simulate natural irradiance JF - Boletim do Instituto Oceanográfico / Universidade de São Paulo Y1 - 1991 SN - 1982-436X; 0080-6331 VL - Vol. 39 IS - No. 2 SP - 155 EP - 159 ER - TY - CHAP A1 - Artmann, Gerhard A1 - Meruvu, Haritha A1 - Kizildag, Sefa A1 - Temiz Artmann, Aysegül ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_7 SP - 157 EP - 192 PB - Springer CY - Singapore ER - TY - BOOK A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül A1 - Zhubanova, Azhar A. A1 - Digel, Ilya ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Biological, physical and technical basics of cell engineering Y1 - 2018 SN - 978-981-10-7903-0 PB - Springer CY - Singapore ER - TY - JOUR A1 - Balakrishnan, Karthikeyan A1 - Andrei-Selmer, Luminita-Cornelia A1 - Selmer, Thorsten A1 - Bacher, Michael A1 - Dodel, Richard T1 - Comparison of Intravenous Immunoglobulins for Naturally Occurring Autoantibodies against Amyloid-β JF - Journal of Alzheimer's Disease Y1 - 2010 SN - 1387-2877 VL - 20 IS - 1 SP - 135 EP - 143 ER - TY - PAT A1 - Bankowski, Bernhard A1 - Hoffmann, Daniele A1 - Wadle, Armin A1 - Siegert, Petra A1 - Sättler, Andrea A1 - Gerke, Thomas T1 - Beta-Glucuronidase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift] T1 - Beta-Glucuronidase inhibitors for use in deodorants and antiperspirants [Europäische Patentanmeldung / Internationale Patentanmeldung] Y1 - 2003 SP - 1 EP - 24 PB - Deutsches Patent- und Markenamt / Europäisches Patentamt / WIPO CY - München / Den Hague / Genf ER - TY - PAT A1 - Banowski, Bernhard A1 - Hoffmann, Daniele A1 - Wadle, Armin A1 - Siegert, Petra A1 - Sättler, Andrea A1 - Gerke, Thomas T1 - Arylsulfatase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift] T1 - Arylsufatas-inhibitors in deodorants and antiperspirants[Europäische Patentschrift / Österreichische Patentanmeldung / Polnische Patentanmeldung / Internationale Patentanmeldung] Y1 - 2002 SP - 1 EP - 22 PB - Deutsches Patent- und Markenamt / Polish Patent Office / WIPO CY - München / Warsaw / Genf ER - TY - PAT A1 - Banowski, Bernhard A1 - Wadle, Armin A1 - Siegert, Petra T1 - Arylsulfatase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift] T1 - Arylsulfatase inhibitors in deodorants and antiperspirants [Europäische Patentanmeldung] Y1 - 2004 SP - 1 EP - 15 PB - Deutsches Patent- und Markenamt / Europäisches Patentamt CY - München / Den Hague ER - TY - PAT A1 - Banowski, Bernhard A1 - Wadle, Armin A1 - Siegert, Petra T1 - Arylsulfatase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift] T1 - Reducing body odor, e.g. in men, comprises applying deodorant or antiperspirant composition containing arylsulfatase-inhibiting phenoxyphenol derivative to skin Y1 - 2003 SP - 1 EP - 20 PB - Deutsches Patent- und Markenamt CY - München ER - TY - PAT A1 - Banowski, Bernhard A1 - Wadle, Armin A1 - Siegert, Petra T1 - Use of hydroxydiphenyl ether derivatives as arylsulfatase-inhibitors in deodorants and antiperspirants [Europäische Patentanmeldung / US Patentanmeldung / Australische Patentanmeldung / Internationale Patentanmeldung] T1 - Verwendung von Hydroxydiphenylether-Derivaten als Arylsulfatase-Hemmer in Deodorants und Antitranspirantien Y1 - 2005 SP - 1 EP - 40 PB - Europäisches Patentamt / USPTO / IP Australia / WIPO CY - Den Hague / Washington / Canberra/ Genf ER - TY - PAT A1 - Banowski, Bernhard A1 - Wadle, Armin A1 - Siegert, Petra A1 - Sättler, Andrea T1 - Lipase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift] T1 - Lipase inhibitors in deodorants and antiperspirants [Europäische Patentanmeldung] Y1 - 2004 SP - 1 EP - 22 PB - Deutsches Patent- und Markenamt / Europäisches Patentamt CY - München / Den Hague ER - TY - PAT A1 - Banowski, Bernhard A1 - Waldmann-Laue, Marianne A1 - Wadle, Armin A1 - Siegert, Petra A1 - Sättler, Andreas T1 - 5-Lipoxigenase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift] T1 - 5-Lipooxygenase inhibitors in deodorants and antiperspirants [Europäische Patentanmeldung] Y1 - 2004 SP - 1 EP - 12 PB - Deutsches Patent- und Markenamt / Europäisches Patentamt CY - München / Den Hague ER - TY - JOUR A1 - Barbazán, Paula A1 - Hagenbach, Adelheid A1 - Paulßen, Elisabeth A1 - Abram, Ulrich A1 - Carballo, Rosa A1 - Rodriguez-Hermida, Sabina A1 - Vázquez-López, Ezequiel M. T1 - Tricarbonyl Rhenium(I) and Technetium(I) Complexes with Hydrazones Derived from 4,5-Diazafluoren-9-one and 1,10-Phenanthroline-5,6-dione JF - European Journal of Inorganic Chemistry N2 - Tricarbonylrhenium(I) and -technetium(I) halide (halide = Cl and Br) complexes of ligands derived from 4,5-diazafluoren-9-one (df) and 1,10-phenanthroline-5,6-dione (phen) derivatives of benzoic and 2-hydroxybenzoic acid hydrazides have been prepared. The complexes have been characterized by elemental analysis, MS, IR, 1H NMR and absorption and emission UV/Vis spectroscopic methods. The metal centres (ReI and TcI) are coordinated through the nitrogen imine atoms and establish five-membered chelate rings, whereas the hydrazone groups stand uncoordinated. The 1H NMR spectra suggest the same behaviour in solution on the basis of only marginal variations in the chemical shifts of the hydrazine protons. Y1 - 2010 U6 - http://dx.doi.org/10.1002/ejic.201000522 SN - 1099-0682 IS - 29 SP - 4622 EP - 4630 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Baumann, Marcus ED - Hempel, G. T1 - Primary production and phytoplankton growth in the marginal ice zone of the Fram Strait and the interpretation of the field data with autecological experiments (Abstract) T2 - Oceanography and biology of Arctic seas : selected papers from the ICES Symposium on Marine Sciences of the Arctic and Subarctic Regions, held in Santander, 28 - 30 September 1987. (Rapports et procès-verbaux des réunions / Conseil International pour l'Exploration de la Mer ; 188) Y1 - 1989 SP - 128 PB - International Council for the Exploration of the Sea CY - Copenhagen ER - TY - JOUR A1 - Baumann, Marcus T1 - Algenblüten & Treibhauseffekt : Wechselwirkungen mit anthropogenen Aktivitäten JF - Wechselwirkung : Wissenschaft & vernetztes Denken Y1 - 1996 SN - 0172-1623 VL - 18 IS - 81 SP - 6 EP - 11 ER - TY - JOUR A1 - Baumann, Marcus A1 - Brandini, Frederico A1 - Staubes, Regina T1 - The influence of light and temperature on carbonspecific DMS release by cultures of Phaeocystis antarctica and three antarctic diatoms / Baumann, Marcus E.M. ; Brandini, Frederico ; Staubes, Regina JF - Marine Chemistry. 45 (1994), H. 1-2 Y1 - 1994 SN - 0304-4203 SP - 129 EP - 136 ER - TY - JOUR A1 - Baumann, Marcus A1 - Goeyens, L. A1 - Semeneh, M. A1 - Elskens, M. T1 - Phytoplankton nutrient utilisation and nutrient signature in the Southern Ocean / Goeyens, L. ; Semeneh, M. ; Baumann, M.E.M. ; Elskens, M. ; Shopova, D. ; Dehairs, F. JF - Journal of Marine Systems. 17 (1998), H. 1-4 Y1 - 1998 SN - 0924-7963 SP - 143 EP - 157 ER - TY - JOUR A1 - Baumann, Marcus A1 - Goeyens, L. A1 - Tréguer, P. A1 - Baeyens, W. T1 - The leading role of ammonium in the nitrogen uptake regime of Southern Ocean marginal ice zones / Goeyens, L. ; Tréguer, P. ; Baumann, M.E.M. ; Baeyens, W. ; Dehairs, F. JF - Journal of Marine Systems. 6 (1995), H. 4 Y1 - 1995 SN - 0924-7963 SP - 345 EP - 361 ER - TY - JOUR A1 - Baumann, Marcus A1 - Gradinger, R. T1 - Distribution of Phytoplankton Communities in Relation to the Large Scale Hydrographical Regime in the Fram Strait 1984 / Gradinger, R. ; Baumann, M.E.M. JF - Marine Biology. 111 (1991), H. 2 Y1 - 1991 SN - 0025-3162 SP - 311 EP - 321 ER - TY - JOUR A1 - Baumann, Marcus A1 - Gronsfeld, A. A1 - Schütz-Lembach, G. T1 - Nachdenklichkeit über Nachhaltigkeit : wie uns ein neues Wort alte Probleme neu entdecken läßt JF - Wechselwirkung : Wissenschaft & vernetztes Denken Y1 - 1997 SN - 0172-1623 VL - 19 IS - 87 SP - 6 EP - 11 ER - TY - JOUR A1 - Baumann, Marcus A1 - Hirche, H.-J. A1 - Kattner, G. A1 - Gradinger, R. T1 - Plankton distribution and the impact of copepod grazing on primary production in Fram Strait, Greenland Sea / Hirche, H.-J. ; Baumann, M.E.M. ; Kattner, G.; Gradinger, R. JF - Journal of Marine Systems. 2 (1991), H. 3-4 Y1 - 1991 SN - 0924-7963 SP - 477 EP - 494 ER - TY - JOUR A1 - Baumann, Marcus A1 - Jahnke, J. T1 - Die marine Planktonalge Phaeocystis globosa / Jahnke, J. ; Baumann, M. JF - Mikrokosmos. 75 (1986), H. 12 Y1 - 1986 SN - 0026-3680 SP - 357 EP - 359 ER - TY - JOUR A1 - Baumann, Marcus A1 - Jahnke, J. T1 - Chemical and Physical Effects on the Shape and Growth of the Diatom Biddulphia sinensis GREVILLE in Batch Cultures: A Contribution to Bioindication in Plankton Ecology / Jahnke, J. ; Baumann, M. JF - Hydrobiological Bulletin . 17 (1983), H. 1 Y1 - 1983 SN - 0165-1404 SP - 5 EP - 20 ER - TY - JOUR A1 - Baumann, Marcus A1 - Jahnke, J. T1 - Marine Planktonalgen der Arktis I. Die Haptophycee Phaeocystis pouchetii / Baumann, M. ; Jahnke, J. JF - Mikrokosmos. 75 (1986), H. 9 Y1 - 1986 SN - 0026-3680 SP - 262 EP - 265 ER - TY - JOUR A1 - Baumann, Marcus A1 - Krämer, M. T1 - Marine Planktonalgen der Arktis II. Diatomeen / Baumann, M. ; Krämer, M. JF - Mikrokosmos. 75 (1986), H. 10 Y1 - 1986 SN - 0026-3680 SP - 306 EP - 310 ER - TY - JOUR A1 - Baumann, Marcus A1 - Lancelot, C. A1 - Brandini, F. A1 - Sakshaug, E. T1 - The taxonomic identity of the cosmopolitan prymnesiophyte Phaeocystis, a morphological and ecophysiological approach / Baumann, M.E.M. ; Lancelot, C. ; Brandini, F. ; Sakshaug, E. ; John M. JF - Journal of Marine Systems. 5 (1994), H. 1 Y1 - 1994 SN - 0924-7963 SP - 5 EP - 22 ER - TY - JOUR A1 - Baumann, Marcus A1 - Lara, R.J. A1 - Hubberten, D.N. A1 - Thomas, D.N. T1 - Dissolved organic matter studies in enclosed systems: Application of hydophobic fractionation for the assessment of organic nitrogen dynamics / Lara, R.J. ; Hubberten, U. ; Thomas, D.N. ; Baumann, M.E.M. ; Kattner, G. JF - Journal of Marine Systems. 13 (1997), H. 1-4 Y1 - 1997 SN - 0924-7963 SP - 155 EP - 161 ER - TY - JOUR A1 - Baumann, Marcus A1 - Peschel, G. T1 - Aktuelle Entwicklungen zur Luftreinhaltung in der Stadt Aachen JF - Wechselwirkung : Wissenschaft & vernetztes Denken Y1 - 1998 SN - 0172-1623 VL - 20 IS - 91 SP - 22 EP - 29 ER - TY - JOUR A1 - Baumann, Marcus A1 - Rousseau, V. A1 - Vaulot, D. A1 - Casotti, R. T1 - The life cycle of Phaeocystis (Prymnesiophycae): evidence and hypotheses / Rousseau, V. ; Vaulot, D. ; Casotti, R. ; Cariou, V. ; Lenz, J. ; Gunkel, J. ; Baumann, M. JF - Journal of Marine Systems. 5 (1994), H. 1 Y1 - 1994 SN - 0924-7963 SP - 23 EP - 39 ER - TY - JOUR A1 - Baumann, Marcus A1 - Semeneh, M. A1 - Dehairs, F. A1 - Elskens, M. T1 - Nitrogen uptake regime and phytoplankton community structure in the Southern Ocean / Semeneh, M. ; Dehairs, F. ; Elskens, M. ; Baumann, M.E.M. ; Kopczynska, E.E. ; Lancelot, C. ; Goeyens, L. JF - Journal of Marine Systems. 17 (1998), H. 1-4 Y1 - 1998 SN - 0924-7963 SP - 159 EP - 177 ER - TY - JOUR A1 - Baumann, Marcus A1 - Thomas, D. A1 - Gleitz, M. T1 - Efficiency of carbon assimilation and photoacclimation in a small unicellular Chaetoceros species from the Weddel Sea (Antarctica): Influence of temperature and irridiance / Thomas, D. ; Baumann, M.E.M. ; Gleitz, M. JF - Journal of Experimental Marine Biology and Ecology. 157 (1992), H. 2 Y1 - 1992 SN - 0022-0981 SP - 195 EP - 209 ER - TY - JOUR A1 - Baumann, Marcus A1 - Tillmann, U. A1 - Aletsee, L. T1 - Distribution of Carbon Among Photosynthetic End Products in the Bloom-Forming Arctic Diatom Thalassiosira antarctica COMBER / Tillmann, U. ; Baumann, M.E.M. ; Aletsee, L. JF - Polar Biology. 10 (1989), H. 3 Y1 - 1989 SN - 0722-4060 SP - 231 EP - 238 ER - TY - BOOK A1 - Baüer, Herbert A1 - Gilch, Heinz Gerhard A1 - Rath, Walter A1 - Schümann, Uwe T1 - Moisture-curing polyurethane-based hot-melt compositions = Feuchthärtbare Heisschmelz-Zusammensetzungen auf Polyurethanbasis Y1 - 1990 N1 - EP0386879 18.10.1990 Veröffentlichungstag im Patentblatt ; Volltext recherchierbar über PB - Europäisches Patentamt CY - München ER - TY - JOUR A1 - Becht, Alexander A1 - Schollmayer, Curd A1 - Monakhova, Yulia A1 - Holzgrabe, Ulrike T1 - Tracing the origin of paracetamol tablets by near-infrared, mid-infrared, and nuclear magnetic resonance spectroscopy using principal component analysis and linear discriminant analysis JF - Analytical and Bioanalytical Chemistry N2 - Most drugs are no longer produced in their own countries by the pharmaceutical companies, but by contract manufacturers or at manufacturing sites in countries that can produce more cheaply. This not only makes it difficult to trace them back but also leaves room for criminal organizations to fake them unnoticed. For these reasons, it is becoming increasingly difficult to determine the exact origin of drugs. The goal of this work was to investigate how exactly this is possible by using different spectroscopic methods like nuclear magnetic resonance and near- and mid-infrared spectroscopy in combination with multivariate data analysis. As an example, 56 out of 64 different paracetamol preparations, collected from 19 countries around the world, were chosen to investigate whether it is possible to determine the pharmaceutical company, manufacturing site, or country of origin. By means of suitable pre-processing of the spectra and the different information contained in each method, principal component analysis was able to evaluate manufacturing relationships between individual companies and to differentiate between production sites or formulations. Linear discriminant analysis showed different results depending on the spectral method and purpose. For all spectroscopic methods, it was found that the classification of the preparations to their manufacturer achieves better results than the classification to their pharmaceutical company. The best results were obtained with nuclear magnetic resonance and near-infrared data, with 94.6%/99.6% and 98.7/100% of the spectra of the preparations correctly assigned to their pharmaceutical company or manufacturer. KW - IR KW - Manufacturer KW - Linear discriminant analysis KW - Principal component analysis Y1 - 2021 U6 - http://dx.doi.org/10.1007/s00216-021-03249-z SN - 1618-2650 VL - 413 SP - 3107 EP - 3118 PB - Springer Nature ER - TY - PAT A1 - Berg, Gabriele A1 - Bessler, Cornelius A1 - Gerlach, Jochen A1 - Gübitz, Georg A1 - Heumann, Sonja A1 - Karl, Wolfgang A1 - Maurer, Karl-Heinz A1 - Remler, Peter A1 - Ribitsch, Doris A1 - Schwab, Helmut A1 - Siegert, Petra A1 - Wieland, Susanne T1 - Mittel enthaltend Proteasen aus Stenotrophomonas maltophilia [Offenlegungsschrift] T1 - Agents containing proteases from Stenotrophomonas maltophilia [Europäische Patentanmeldung / US Patentanmeldung / Internationale Patentanmeldung] Y1 - 2009 SP - 1 EP - 47 PB - Deutsches Patent- und Markenamt / Europäisches Patentamt / USPTO / WIPO CY - München / Den Hague / Washington / Genf ER - TY - JOUR A1 - Bergs, Michel A1 - Monakhova, Yulia A1 - Diehl, Bernd W. A1 - Konow, Christopher A1 - Völkering, Georg A1 - Pude, Ralf A1 - Schulze, Margit T1 - Lignins isolated via catalyst-free organosolv pulping from Miscanthus x giganteus, M. sinensis, M. robustus and M. nagara: a comparative study JF - Molecules N2 - As a low-input crop, Miscanthus offers numerous advantages that, in addition to agricultural applications, permits its exploitation for energy, fuel, and material production. Depending on the Miscanthus genotype, season, and harvest time as well as plant component (leaf versus stem), correlations between structure and properties of the corresponding isolated lignins differ. Here, a comparative study is presented between lignins isolated from M. x giganteus, M. sinensis, M. robustus and M. nagara using a catalyst-free organosolv pulping process. The lignins from different plant constituents are also compared regarding their similarities and differences regarding monolignol ratio and important linkages. Results showed that the plant genotype has the weakest influence on monolignol content and interunit linkages. In contrast, structural differences are more significant among lignins of different harvest time and/or season. Analyses were performed using fast and simple methods such as nuclear magnetic resonance (NMR) spectroscopy. Data was assigned to four different linkages (A: β-O-4 linkage, B: phenylcoumaran, C: resinol, D: β-unsaturated ester). In conclusion, A content is particularly high in leaf-derived lignins at just under 70% and significantly lower in stem and mixture lignins at around 60% and almost 65%. The second most common linkage pattern is D in all isolated lignins, the proportion of which is also strongly dependent on the crop portion. Both stem and mixture lignins, have a relatively high share of approximately 20% or more (maximum is M. sinensis Sin2 with over 30%). In the leaf-derived lignins, the proportions are significantly lower on average. Stem samples should be chosen if the highest possible lignin content is desired, specifically from the M. x giganteus genotype, which revealed lignin contents up to 27%. Due to the better frost resistance and higher stem stability, M. nagara offers some advantages compared to M. x giganteus. Miscanthus crops are shown to be very attractive lignocellulose feedstock (LCF) for second generation biorefineries and lignin generation in Europe. Y1 - 2021 U6 - http://dx.doi.org/10.3390/molecules26040842 SN - 1420-3049 N1 - Special Issue Lignin – A Natural Resource with Huge Potential https://www.mdpi.com/journal/molecules/special_issues/lignin_natural VL - 26 IS - 4 PB - MDPI CY - Basel ER - TY - THES A1 - Berndt, Heinz T1 - Zur Synthese der Sequenz 60-84[Ala71, Gly72, Val73] des Schweineproinsulins als monomeres cyclisches Bis-Cystinpeptidderivat Y1 - 1972 N1 - Aachen, Techn. Hochsch., Diss. 1972 CY - Aachen ER - TY - BOOK A1 - Berndt, Heinz T1 - Neue Kondensations-Methoden zur Synthese definierter Peptid-Derivate Y1 - 2014 N1 - Aachen, Techn. Hochsch., Habil.-Schr., 1982 CY - Aachen ER - TY - JOUR A1 - Berndt, Heinz T1 - Synthese der Sequenz 71—86 des Humanproinsulins, III : Synthese über die Fragmente 71—78 und 79—86 JF - Hoppe-Seyler's Zeitschrift für physiologische Chemie Y1 - 1979 U6 - http://dx.doi.org/10.1515/bchm2.1979.360.1.765 SN - 1437-4315 SN - 0018-4888 VL - 360 IS - 1 SP - 765 EP - 772 ER - TY - JOUR A1 - Berndt, Heinz T1 - Synthese der Sequenz 71—86 des Humanproinsulins, I : Synthese der Sequenz 71—86 als monomeres cyclisches Biscystinpeptidderivat und als Tetra-S-tritylderivat JF - Hoppe-Seyler's Zeitschrift für physiologische Chemie Y1 - 1979 U6 - http://dx.doi.org/10.1515/bchm2.1979.360.1.747 SN - 1437-4315 SN - 0018-4888 VL - 360 IS - 1 SP - 747 EP - 760 ER - TY - JOUR A1 - Berndt, Heinz T1 - Zur Reaktion von Iminodithiocarbonaten mit Carbonsäuren. I : Synthese des Modellpeptid-Derivates Z-(L)-Ala-(L/D)-Phe-(L)-Val-OMe JF - Tetrahedron letters Y1 - 1980 U6 - http://dx.doi.org/10.1016/S0040-4039(00)78663-1 SN - 0040-4039 VL - 21 IS - 34 SP - 3265 EP - 3268 ER - TY - JOUR A1 - Berndt, Heinz A1 - Gattner, Hans-Gregor A1 - Zahn, Helmut T1 - Semisynthetisches Des-A1-glycin-Schafinsulin JF - Biological Chemistry Y1 - 1975 U6 - http://dx.doi.org/10.1515/bchm2.1975.356.2.1455 SN - 1437-4315 VL - 356 IS - 2 SP - 1469 EP - 1472 PB - De Gruyter CY - Berlin ER - TY - PAT A1 - Berndt, Heinz A1 - Höcker, Hartwig A1 - Kuropka, Rolf A1 - Kinkel, Joachim T1 - Silanderivate : Europäische Patenschrift / Offenlegungsschrift T1 - Silane derivatives : Europäische Patenschrift / Offenlegungsschrift Y1 - 1991 PB - Europäisches Patentamt / Deutsches Patent- und Markenamt CY - Den Hague / München ER - TY - PAT A1 - Berndt, Heinz A1 - Höcker, Hartwig A1 - Kuropka, Rolf A1 - Kinkel, Joachim T1 - Silane coated inorganic materials for chromatography : United States Patent Y1 - 1991 PB - [The United States Patent and Trademark Office] CY - [Alexandria, VA u.a.] ER - TY - CHAP A1 - Berndt, Heinz A1 - Kalbe, Jochen A1 - Kuropka, Rolf A1 - Meyer-Stork, L. Sebastian A1 - Höcker, Hartwig ED - Körner, Andrea T1 - Progress and limitations of the DNA analysis in fine animal fiber identification T2 - Proceedings of the 2nd International Symposium on Specialty Animal Fibers : Aachen, October 19 - 20, 1989. - (Schriftenreihe des Deutschen Wollforschungsinstituts an der Technischen Hochschule Aachen e. V. ; 106) Y1 - 1990 SP - 259 EP - 265 PB - Dt. Wollforschungsinst. CY - Aachen ER - TY - CHAP A1 - Berndt, Heinz A1 - Kalbe, Jochen A1 - Kuropka, Rolf A1 - Meyer-Stork, L. Sebastian A1 - Sauter, S. L. A1 - Höcker, Hartwig T1 - Eindeutige Charakterisierung von Tierhaaren und Tierhaar-Mischungen durch DNA-Analytik T2 - Beiträge zur 15. Gemeinsamen Tagung der Aachener Textilforschungsinstitute und des "Wollfadens", zugleich 32. Arbeitstagung des Deutschen Wollforschungsinstitutes an der Technischen Hochschule Aachen : am 06. und 07. Oktober 1988. - (Schriftenreihe des Deutschen Wollforschungsinstituts an der Technischen Hochschule Aachen e. V. ; 104) Y1 - 1989 SN - 0930-3723 SP - 29 EP - 32 PB - Dt. Wollforschungsinst. CY - Aachen ER - TY - JOUR A1 - Berndt, Heinz A1 - Klostermeyer, Henning A1 - Zahn, Helmut T1 - Zur Synthese monomerer cyclischer Cystinpeptidderivate, I : Synthese der Sequenz A 6–9 des Schafinsulins als Cyclocystinylderivat JF - Justus Liebigs Annalen der Chemie N2 - Es wird die Synthese der Sequenz A 6–9 des Schafinsulins in der geschützten Form Boc-Cys-Cys-Ala-Gly-OBuᵗ (5) sowie das Verhalten dieses monomeren cyclischen Cystinpeptidderivates gegenüber den in der Peptidchemie gebräuchlichen Reagenzien Bortrifluorid/Eisessig, Triäthylamin und Hydrazinhydrat beschrieben. Y1 - 1972 U6 - http://dx.doi.org/10.1002/jlac.19727590109 SN - 1099-0690 VL - 759 IS - 1 SP - 114 EP - 120 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Berndt, Heinz A1 - Krüger, Götz T1 - Resolution of enantiomeric amino acid derivatives by high-performance liquid chromatography on chiral stationary phases JF - Journal of chromatography A Y1 - 1985 U6 - http://dx.doi.org/10.1016/S0021-9673(01)92461-6 SN - 0021-9673 VL - 1985 IS - 348 SP - 275 EP - 279 ER - TY - CHAP A1 - Berndt, Heinz A1 - Turck, Christoph W. ED - Voelter, Wolfgang T1 - Syntheses of defined peptide derivatives by aminolysis of 3-[Nα-benzyloxycarbonyl peptidyloxy] -2-hydroxy-N-methyl-benzamides at elevated temperatures II. Synthesis of the peptide derivatives Z-Ala-X-Gly-N(Et)2, X=Phe, Leu, Val, Ser (But), Glu (OBut) T2 - Chemistry of peptides and proteins : proceedings of the Fourth USSR-FRG Symposium, Tübingen, Federal Republic of Germany, June 8 - 12, 1982 / ed. Wolfgang Voelter ... - Vol. 2 Y1 - 1984 SN - 3-11009-580-7 SP - 97 EP - 103 PB - de Gruyter CY - Berlin [u.a.] ER - TY - JOUR A1 - Berndt, Heinz A1 - Zahn, Helmut T1 - Peptide, 99 : Monomere cyclische Cystinpeptidderivate, III ; Synthese der Schafinsulin-A-Kettensequenzen A2–21 und A1–21 als monomere cyclische Dicystinpeptidderivate JF - Justus Liebigs Annalen der Chemie N2 - Die Synthese der Sequenzen A2—21 (13) und A1—21 (15) der Schafinsulin-A-Kette als monomere cyclische Dicystinpeptidderivate wird beschrieben. Die intrachenaren Cystinbrücken A6—7 und A 11 —20 vermitteln die Löslichkeit dieser Derivate in Dimethylformamid und ermöglichen erstmalig die Reindarstellung vollgeschützter Insulin-A-Kettenderivate. Die während der Synthese eingesetzten Schutzgruppen lassen sich mittels Trifluoressigsäure und 2-Mercaptoäthanol quantitativ entfernen. Y1 - 1975 U6 - http://dx.doi.org/10.1002/jlac.197519750908 SN - 1099-0690 VL - 1975 IS - 9 SP - 1601 EP - 1612 PB - Wiley-VCH CY - Weinheim ER - TY - PAT A1 - Bessler, Cornelius A1 - Evers, Stefan A1 - Maurer, Karl-Heinz A1 - Merkel, Marion A1 - Siegert, Petra A1 - Weber, Angrit A1 - Wieland, Susanne T1 - Leistungsverbesserte Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen [Offenlegungsschrift] T1 - Improved-performance proteases and detergents and cleaning agents comprising said proteases [Internationale Patentanmeldung] Y1 - 2009 SP - 1 EP - 41 PB - Deutsches Patent- und Markenamt / WIPO CY - München / Genf ER - TY - PAT A1 - Bessler, Cornelius A1 - Maurer, Karl-Heinz A1 - Merkel, Marion A1 - Siegert, Petra A1 - Wieland, Susanne T1 - Subtilisin from Bacillus Pumilus and detergent and cleaning agents containing said novel subtilisin [US Patentanmeldung / Internationale Patentanmeldung] Y1 - 2009 SP - 1 EP - 39 PB - USPTO; WIPO CY - Washington; Genf ER - TY - PAT A1 - Bessler, Cornelius A1 - Maurer, Karl-Heinz A1 - Merkel, Marion A1 - Siegert, Petra A1 - Wieland, Susanne T1 - Subtilisin aus Bacillus pumilus und Wasch- und Reinigungsmittel enthaltend dieses neue Subtilisin [Offenlegungsschrift] T1 - Subtilisin from Bacillus pumilus and washing and cleaning agents containing said novel subtilisin [Europäische Patentanmeldung / Internationale Patentanmeldung / Kanadische Patentanmeldung] Y1 - 2007 SP - 1 EP - 47 PB - Deutsches Patent- und Markenamt / Europäisches Patentamt / WIPO / CIPO CY - München / Den Hague / Genf ER - TY - BOOK A1 - Biselli, Manfred T1 - Enzymkatalysierte Racematspaltung von Aminosäuren mit integrierter Rückführung : dargestellt am Beispiel der Umsetzung von D,L-Alanin zu L-Alanin / Manfred Fridolin Biselli Y1 - 1992 N1 - Berichte des Forschungszentrums Jülich ; 2581 PB - Forschungszentrum Jülich, Zentralbibliothek CY - Jülich ER - TY - BOOK A1 - Biselli, Manfred T1 - Enzymkatalysierte Racematspaltung von Aminosäuren mit integrierter Rückführung : dargestellt am Beispiel der Umsetzung von D,L-Alanin zu L-Alanin / vorgelegt von Manfred Fridolin Biselli Y1 - 1992 N1 - Bonn, Univ., Diss., 1991 CY - Bonn ER - TY - JOUR A1 - Biselli, Manfred A1 - Born, C. A1 - Thömmes, J. A1 - Wandrey, C. T1 - An approach to integrated antibody production: Coupling of fluidized bed cultivation and fluidized bed adsorption / Born, C. ; Thömmes, J. ; Biselli, M. ; Wandrey, C. ; Kula, M.-R. JF - Bioprocess Engineering. 15 (1996), H. 1 Y1 - 1996 SN - 1615-7591 SP - 21 EP - 29 ER - TY - JOUR A1 - Biselli, Manfred A1 - Born, C. A1 - Wandrey, C. T1 - Oxygen transfer from the gasphase to the immobilized cells in membrane aerated fluidized beds / Born, C. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : basic & applied aspects : proceedings of the Eighth Annual Meeting of the Japanese Association for Animal Cell Technology, Iizuka, Fukuoka, Japan, November 6-10, 1995 / edited by K. Funatsu, Y. Shirai, and T. Matsushita Y1 - 1995 SN - 0-7923-4486-3 N1 - Japanese Association for Animal Cell Technology. ; Meeting ; <8 ; 1995 : ; Iizuka-shi, Japan> SP - 83 EP - 87 PB - Kluwer Acad. Press CY - Boston ER - TY - JOUR A1 - Biselli, Manfred A1 - Born, C. A1 - Wandrey, C. T1 - Production of monoclonal antibodies in a pilot scale fluidized bed bioreactor / Born, C.; Biselli, M.; Wandrey, C. JF - Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery Y1 - 1995 SN - 0-7923-3736-0 N1 - Meeting "Animal Cell Technology, Developments towards the 21st Century" ; <1994.09.12-16 : ; Veldhoven> SP - 515 EP - 519 PB - Kluwer Acad. Press CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Schnitzler, Thomas A1 - Zang, Werner A1 - Wagner, P. T1 - Entwicklung eines modularen festkörperbasierten Sensorsystems für die Überwachung von Zellkulturfermenationen JF - Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA) Y1 - 2010 SN - 978-3-8007-3260-9 N1 - Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik SP - 688 EP - 691 PB - VDE Verlag CY - Berlin ER - TY - JOUR A1 - Biselli, Manfred A1 - Hambach, B. A1 - Runstadler, P. W. A1 - Wandrey, Christian T1 - Development of a reactor-integrated aeration system for cultivation of animal cells in fluidized beds / Hambach, B. ; Biselli, M. ; Runstadler, P.W. ; Wandrey, C. JF - Animal cell technology : developments, processes, and products ; ESACT, European Society for Animal Cell Technology, the 11th meeting / Ed. R. E. Spier Y1 - 1992 SN - 0750604212 SP - 381 EP - 385 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Hilbert, U. A1 - Jelinek, N. A1 - Schmidt, S. T1 - Bioprocess development for the cultivation of human T-lymphocytes / Hilbert, U. ; Jelinek, N. Schmidt, S. ; Biselli, M. JF - Engineering in Life Sciences. 1 (2001) Y1 - 2001 SN - 1618-0240 SP - 20 EP - 23 ER - TY - JOUR A1 - Biselli, Manfred A1 - Hilbert, U. A1 - Noll, T. T1 - Cultivation of Human HCMV Specific Lymphocytes – An Example for Adoptive Immunotherapy / Hilbert, U. ; Biselli, M. ; Noll, T. JF - Animal cell technology : from target to market ; Tylösand, Sweden, June 10 - 14, 2001 / ed. by E. Lindner-Olsson ... Y1 - 2001 SN - 1-4020-0264-5 N1 - Proceedings of the ... ESACT meeting ; 17 SP - 558 EP - 561 PB - Kluwer CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Hilbert, Ulrike A1 - Jelinek, Nanni A1 - Schmidt, Sebastian T1 - Biotechnologische Aspekte der Kultivierung humaner T-Lymphozyten / Hilbert, Ulrike ; Jelinek, Nanni ; Schmidt, Sebastian ; Biselli, Manfred JF - Chemie Ingenieur Technik. 72 (2000), H. 7 Y1 - 2000 SN - 1522-2640 SP - 746 EP - 750 ER - TY - JOUR A1 - Biselli, Manfred A1 - Jelinek, N. A1 - Schmidt, S. A1 - Hilbert, U. T1 - Neue Bioreaktoren zur Kultivierung hämatopoetischer Zellen / Jelinek, N. ; Schmidt, S. ; Hilbert, U. ; Thoma, S. ; Biselli, M. ; Wandrey, C. JF - Chemie Ingenieur Technik. 73 (2001), H. 7 Y1 - 2001 SN - 0009-286X SP - 894 EP - 898 ER - TY - JOUR A1 - Biselli, Manfred A1 - Jelinek, N. A1 - Schmidt, S. A1 - Hilbert, U. T1 - Novel bioreactors for the ex vivo cultivation of hematopoietic cells / Jelinek, N. ; Schmidt, S. ; Hilbert, U. ; Thoma, S. ; Biselli, M. ; Wandrey, C. JF - Engineering in Life Sciences. 2 (2002), H. 1 Y1 - 2002 SN - 1618-0240 SP - 15 EP - 18 ER - TY - JOUR A1 - Biselli, Manfred A1 - Jelinek, N. A1 - Schmidt, S. A1 - Noll, T. T1 - Bioreaktoren zur Kultivierung blutbildender Zellen / Jelinek, N. ; Schmidt, S. ; Noll, T. ; Biselli, M. JF - Bioforum. 24 (2001), H. 6 Y1 - 2001 SN - 0940-0079 SP - 418 EP - 419 ER - TY - JOUR A1 - Biselli, Manfred A1 - Klyushnichenko, Vadim A1 - Rodenbrock, Anja A1 - Thömmes, Jörg T1 - Analysis of Hybridoma Cell Culture Processes by SDS-Gel Capillary Electrophoresis and matrix-assisted laser desorption ionization–time-of-flight MS / Vadim Klyushnichenko, Anja Rodenbrock, Jörg Thömmes, Maria-Regina Kula, Holger Heine, Manfred Biselli JF - Biotechnology and Applied Biochemistry. 27 (1998), H. 3 Y1 - 1998 SN - 0885-4513 SP - 181 EP - 188 ER - TY - JOUR A1 - Biselli, Manfred A1 - Kragl, U. A1 - Wandrey, C. T1 - Reaction Engineering for Enzyme-Catalyzed Biotransformations JF - Enzyme catalysis in organic synthesis : a comprehensive handbook. Bd. 1. - 2., completely rev. and enl. ed. / ed. by Karlheinz Drauz. Y1 - 2002 SN - 3-527-29949-1 N1 - erschienen: Vol. 1-3 SP - 185 EP - 257 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Biselli, Manfred A1 - Kragl, U. A1 - Wandrey, C. T1 - Reaction Engineering for Enzyme-Catalyzed Biotransformations JF - Enzyme catalysis in organic synthesis : a comprehensive handbook. Bd. 1. / ed. by Karlheinz Drauz. Y1 - 1995 SN - 3-527-28479-6 N1 - erschienen: Vol. 1-2 SP - 89 EP - 155 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Biselli, Manfred A1 - Lüllau, E. A1 - Dreisbach, C. A1 - Grogg, A. T1 - Immobilization of animal cells on chemically modified siran carrier / Lüllau, E. ; Dreisbach, C. ; Grogg, A. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : developments, processes, and products ; ESACT, European Society for Animal Cell Technology, the 11th meeting / Ed. R. E. Spier Y1 - 1992 SN - 0750604212 SP - 469 EP - 475 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Lüllau, E. A1 - Wandrey, Christian T1 - Growth and metabolism of CHO-cells in porous glass carriers / Lüllau, E. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier Y1 - 1994 SN - 0750618450 N1 - Meeting / European Society for Animal Cell Technology ; 12 SP - 252 EP - 255 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Machnik, M. A1 - Wandrey, C. T1 - Online-Immunoanalytik bei der kontinuierlichen Fermentation von Hybridomazellen / Machnik, M. ; Biselli, M. ; Wandrey, C. JF - BIO WORLD. 1 (1996), H. 3 Y1 - 1996 SN - 1424-8514 SP - 12 EP - 15 ER - TY - JOUR A1 - Biselli, Manfred A1 - Meissner, Petra A1 - Schröder, Bernd A1 - Herfurth, Cornelia T1 - Development of a fixed bed bioreactor for the expansion of human hematopoietic progenitor cells / Meissner, Petra ; Schröder, Bernd ; Herfurth, Cornelia ; Biselli, Manfred JF - Cytotechnology. 30 (1999), H. 1 Y1 - 1999 SN - 0920-9069 SP - 227 EP - 234 ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, T. T1 - Dielectric spectroscopy in the cultivation of suspended and immobilized hybridoma cells / Noll, T.; Biselli, M. JF - Journal of Biotechnology. 63 (1998), H. 3 Y1 - 1998 SN - 0168-1656 SP - 187 EP - 198 ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, T. A1 - Wandrey, C. T1 - Wirbelschichtreaktor und Biomasse-Monitor : ein leistungsfähiges Fermenationssystem für Säugerzellen / Noll, T. ; Biselli, M. ; Wandrey, C. JF - Biospektrum. 2 (1996), H. 1 Y1 - 1996 SN - 0947-0867 SP - 65 EP - 67 ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, T. A1 - Wandrey, C. T1 - On-line biomass monitoring of immobilized hybridoma cells by dielectrical measurements / Noll, T. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : from vaccines to genetic medicine ; [Vilamoura, Portugal, May 1996] / ed. by Manuel J. T. Carrondo Y1 - 1997 SN - 0-7923-4321-2 SP - 289 EP - 294 PB - Kluwer CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, Thomas A1 - Eisenkrätzer, Detlef A1 - Kiesewetter, André T1 - Improved product formation in high density Chinese hamster ovary cell cultures transfected at confluency / Thomas Noll, Detlef Eisenkrätzer, André Kiesewetter, André Dinter, Steffen Zeng, Christian Wandrey, Manfred Biselli und Eric G. Berger JF - Biotechnology Letters. 24 (2002), H. 11 Y1 - 2002 SN - 0141-5492 SP - 861 EP - 866 ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, Thomas A1 - Jelinek, Nanni A1 - Schmidt, Sebastian T1 - Cultivation of Hematopoietic Stem and Progenitor Cells: biochemical Engineering Aspects / Thomas Noll, Nanni Jelinek, Sebastian Schmidt, Manfred Biselli und Christian Wandrey JF - Tools and Applications of Biochemical Engineering Science Y1 - 2002 SN - 3-540-42250-1 N1 - Advances in Biochemical Engineering/Biotechnology. 74 SP - 111 EP - 128 PB - Springer CY - Berlin ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, Thomas A1 - Mühlsiepen, Heinz A1 - Engels, Ralf T1 - A cell-culture reactor for the on-line evaluation of radiopharmaceuticals : evaluation of the lumped constant of FDG in human glioma cells / Noll, Thomas ; Mühlensiepen, Heinz ; Engels, Ralf ; Hamacher, Kurt ; Papaspyrou, Manfred ; Langen, Karl-Josef ; Bi JF - Journal of Nuclear Medicine. 41 (2000), H. 3 Y1 - 2000 SN - 0022-3123 SP - 556 EP - 564 ER - TY - JOUR A1 - Biselli, Manfred A1 - Rechmann, Hanrik A1 - Friedrich, Andrea A1 - Forouzan, Dara T1 - Characterization of photosynthetically active duckweed ( Wolffia australiana ) in vitro culture by Respiration Activity Monitoring System (RAMOS) / Henrik Rechmann, Andrea Friedrich, Dara Forouzan, Stefan Barth, Heide Schnabl, Manfred Biselli und Robert B JF - Biotechnology Letters. 29 (2007), H. 6 Y1 - 2007 SN - 0141-5492 SP - 971 EP - 977 ER - TY - JOUR A1 - Biselli, Manfred A1 - Rolef, G. A1 - Dunker, R. A1 - Wandrey, Christian T1 - Optimization of antibody production in a fluidized bed bioreactor / Rolef, G. ; Biselli, M. ; Dunker, R. ; Wandrey, C. JF - Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier Y1 - 1994 SN - 0750618450 N1 - Meeting / European Society for Animal Cell Technology ; 12 SP - 481 EP - 484 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Schmid, Georg A1 - Wandrey, Christian T1 - Preparation of cellodextrins and isolation of oligomeric side components and their characterization / Schmid, Georg ; Biselli, Manfred ; Wandrey, Christian JF - Analytical Biochemistry. 175 (1988) Y1 - 1988 SN - 0003-2697 SP - 573 EP - 583 ER - TY - JOUR A1 - Biselli, Manfred A1 - Schmidt, S. A1 - Büchs, J. A1 - Born, C. T1 - A new correlation for the wall-to-fluid mass transfer in liquid-sol fluidized beds / Schmidt, S. ; Büchs, J. ; Born, C. ; Biselli, M. JF - Chemical Engineering Science. 54 (1999), H. 6 Y1 - 1999 SN - 0009-2509 SP - 829 EP - 839 ER - TY - JOUR A1 - Biselli, Manfred A1 - Schröder, B. A1 - Herfurth, C. A1 - Meißner, P. T1 - Differentiation of bone marrow cells immobilized on microcarriers in a fluidized bed reactor / Schröder, B. ; Herfurth, C. ; Meißner, P. ; Biselli, M. ; Link, H. ; Wandrey, C. JF - Animal cell technology : from vaccines to genetic medicine ; [Vilamoura, Portugal, May 1996] / ed. by Manuel J. T. Carrondo Y1 - 1997 SN - 0-7923-4321-2 SP - 589 EP - 593 PB - Kluwer CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Schröder, B. A1 - Herfurth, C. A1 - Schmoll, H.-J. T1 - Cocultivation of hematopoietic cells in a fluidized bed reactor / Schröder, B. ; Herfurth, C. ; Biselli, M. ; Schmoll, H.-J. ; Link, H. ; Ebell, W. ; Wandrey, C. JF - Animal cell technology : basic & applied aspects : proceedings of the Eighth Annual Meeting of the Japanese Association for Animal Cell Technology, Iizuka, Fukuoka, Japan, November 6-10, 1995 / edited by K. Funatsu, Y. Shirai, and T. Matsushita Y1 - 1997 SN - 0-7923-4486-3 N1 - Japanese Association for Animal Cell Technology. ; Meeting ; <8 ; 1995 : ; Iizuka-shi, Japan> SP - 137 EP - 141 PB - Kluwer Acad. Press CY - Boston ER - TY - JOUR A1 - Biselli, Manfred A1 - Thömmes, J. A1 - Born, C. A1 - Wandrey, C. T1 - Purification of monoclonal antibodies by fluidized bed adsorption / Thömmes, J. ; Born, C. Biselli, M. ; Wandrey, C. ; Kula, M.-R. JF - Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery Y1 - 1995 SN - 0-7923-3736-0 N1 - Meeting "Animal Cell Technology, Developments towards the 21st Century" ; <1994.09.12-16 : ; Veldhoven> SP - 515 EP - 519 PB - Kluwer Acad. Press CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Thömmes, J. A1 - Garske, U. A1 - Wandrey, Christian T1 - Integrated detoxification: Reduction of ammonium concentration by dialysis with cation exchange membranes / Thömmes, J. ; Garske, U. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : developments, processes, and products ; ESACT, European Society for Animal Cell Technology, the 11th meeting / Ed. R. E. Spier Y1 - 1992 SN - 0750604212 SP - 171 EP - 175 PB - Butterworth-Heinemann CY - Oxford ER -