TY  - CHAP
A1  - Ögun, Celal Mohan
A1  - Kling, Rainer
A1  - Heuermann, Holger
A1  - Gräser, Ulrich
A1  - Schopp, Christoph
T1  - Elektrodenlose quecksilberfreie Niederdrucklampen betrieben mit Mikrowellen
T2  - Licht 2014 [Elektronische Ressource] : Den Haag, Holland ; 21. Gemeinschaftstagung, 21. bis 24. September 2014 ; Tagungsband
Y1  - 2014
PB  - Nederlandse Stichting voor Verlichtingskunde
CY  - Ede
ER  - 
TY  - JOUR
A1  - Yang, Peng-Fei
A1  - Kriechbaumer, Andreas
A1  - Albracht, Kirsten
A1  - Sanno, Maximilian
A1  - Ganse, Bergita
A1  - Koy, Timmo
A1  - Shang, Peng
A1  - brüggemann, Gert-Peter
A1  - Müller, Lars Peter
A1  - Rittweger, Jörn
T1  - A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans
JF  - Journal of Orthopaedic Translation
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.jot.2014.07.078
SN  - 2214-0328
SN  - 2214-031X
VL  - 2
IS  - 4
SP  - 238
EP  - 238
PB  - Elsevier
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Wu, Chunsheng
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Werner, Frederik
A1  - Bäcker, Matthias
A1  - Schöning, Michael Josef
T1  - Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips
JF  - Physica status solidi A : Applications and materials science
N2  - A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al–p-Si–SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent–voltage (I–V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I–V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201330442
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1423
EP  - 1428
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Wu, Chunsheng
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - DNA-hybridization detection using light-addressable potentiometric sensor modified with gold layer
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 4
PB  - VDE-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - Funkstandards für Sensornetzwerke
JF  - Elektronik : Fachmedium für industrielle Anwender und Entwickler
Y1  - 2014
SN  - 0013-5658
VL  - Bd. 63
IS  - H. 12
SP  - 36
EP  - 41
PB  - WEKA-Fachmedien
CY  - Haar
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - Echtzeit-Ethernet : Protokoll-Reigen
JF  - Elektronik : Fachmedium für industrielle Anwender und Entwickler
Y1  - 2014
SN  - 0013-5658
VL  - Bd. 63
IS  - H. 26
SP  - 24
EP  - 31
PB  - WEKA-Fachmedien
CY  - Haar
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - Der Embedded Wireless-Report
JF  - Elektronik : Fachmedium für industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium für Entwicklungen funkbasierter Systeme
Y1  - 2014
SN  - 0013-5658
SP  - 18
EP  - 25
PB  - WEKA-Fachmedien
CY  - Haar
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - Echtzeit-Ethernet mit Standardtechnik
JF  - Elektronik : Fachmedium für industrielle Anwender und Entwickler ; Sonderh. Embedded : Fachmagazin für die Entwicklung von Embedded-Systemen
Y1  - 2014
SN  - 0013-5658
VL  - Bd. 63
IS  - H. 12
SP  - 28
EP  - 32
PB  - WEKA-Fachmedien
CY  - Haar
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - Feldbustechnologie
JF  - Factory : der Durchblick in der Technik
Y1  - 2014
SP  - Publ. online
PB  - WEKA-Industriemedien
CY  - Wien
ER  - 
TY  - CHAP
A1  - Wolff, Nino
A1  - Seefeldt, Patric
A1  - Bauer, Wolfgang
A1  - Fiebig, Christopher
A1  - Gerding, Patrick
A1  - Parow-Souchon, Kai
A1  - Pongs, Anna
A1  - Reiffenrath, Matti
A1  - Ziemann, Thomas
T1  - Alternative application of solar sail technology
T2  - Advances in solar sailing
N2  - The development of Gossamer sail structures for solar sails contributes to a large field of future space applications like thin film solar generators, membrane antennas and drag sails. The focus of this paper is the development of a drag sail based on solar sail technology that could contribute to a reduction of space debris in low Earth orbits. The drag sail design and its connections to solar sail development, a first test on a sounding rocket, as well as the ongoing integration of the drag sail into a triple CubeSat is presented.
Y1  - 2014
SN  - 978-3-642-34906-5 (Print) ; 978-3-642-34907-2 (E-Book)
U6  - http://dx.doi.org/10.1007/978-3-642-34907-2_23
SP  - 351
EP  - 365
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wolf, Martin
A1  - Biesen, Ina van der
A1  - Greeb, Birgit
T1  - Mein Freund, die Uni
JF  - Die neue Hochschule : DNH : für anwendungsbezogene Wissenschaft und Kunst
Y1  - 2014
SN  - 0340-448X
N1  - Gedr. Ausgabe in der Bibliothek Eupener Str. vorhanden.
VL  - 2014
IS  - 2
SP  - 54
EP  - 56
PB  - HLB
CY  - Bonn
ER  - 
TY  - JOUR
A1  - Winckler, Silvia
A1  - Krueger, Rolf
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Fischer, Rainer
A1  - Biselli, Manfred
T1  - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach
JF  - Bioprocess and biosystems engineering
N2  - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Y1  - 2014
U6  - http://dx.doi.org/10.1007/s00449-013-1062-8
SN  - 1615-7591 (Print) 1615-7605 (Online)
VL  - 37
IS  - 5
SP  - 901
EP  - 912
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - Gebaute Geschichte in Turin
JF  - Kunsttexte.de
N2  - Städte sind Stein gewordene Geschichte. Ihre realisierte Form ermöglicht Geschichte zu erleben und die Stadtentwicklung nachzuvollziehen. Besonders in Turin ist ablesbar, wie das Haus Savoyen den Ausbau der neuen Hauptstadt zu einer der führenden Barockmetropolen Europas beeinflusste.
Y1  - 2014
U6  - http://dx.doi.org/10.18452/7197
SN  - 1618-8101
VL  - 2014
IS  - 1
PB  - Humboldt-Universität zu Berlin
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wiesen, Sebastian
A1  - Tippkötter, Nils
A1  - Muffler, Kai
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Nils
A1  - Ulber, Roland
T1  - Adsorptive Vorbehandlung von Rohglycerin für die 1,3-Propandiol Fermentation mit Clostridium diolis
JF  - Chemie Ingenieur Technik
N2  - Bei der Gewinnung von Fettsäuren aus Pflanzenölen, z. B. zur Herstellung von Biopolymeren, oder bei der Biodiesel- und Seifenproduktion, fällt Glycerin als Nebenprodukt an. Bei der Biokonversion dieses Rohstoffes zu 1,3-Propandiol wird der Produktionsorganismus Clostridium diolis durch Verunreinigungen im Rohglycerin gehemmt. Als inhibierende Substanzen konnten freie Fettsäuren identifiziert werden. Mithilfe eines adsorptiven Aufarbeitungsverfahrens ist es gelungen, die Fettsäuren zu entfernen und die Konversionseffizienz zu 1,3-Propandiol zu erhöhen.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/cite.201300080
N1  - Englischer Titel: Adsorptive Pretreatment of Crude Glycerol Prior to Fermentation to 1,3-Propanediole by Clostridium Diolis
VL  - 86
IS  - 1-2
SP  - 129
EP  - 135
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Whitehead, Mark
A1  - Öhlschläger, Peter
A1  - Almajhdi, Fahad N.
A1  - Alloza, Leonor
A1  - Marzábal, Pablo
A1  - Meyers, Ann E.
A1  - Hitzeroth, Inga I.
A1  - Rybicki, Edward P.
T1  - Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice
JF  - BMC cancer
Y1  - 2014
U6  - http://dx.doi.org/10.1186/1471-2407-14-367
SN  - 1471-2407
IS  - 14:367
SP  - 1
EP  - 15
PB  - BioMed Central
CY  - London
ER  - 
TY  - CHAP
A1  - Wetter, Martin
A1  - Kern, Alexander
T1  - Number of lightning strikes to tall structures - comparison of calculations and measurements using a modern lightning monitoring system
T2  - 2014 International Conference on Lightning Protection (ICLP), Shanghai, China
Y1  - 2014
SP  - 1
EP  - 7
ER  - 
TY  - CHAP
A1  - Werner, Frederik
A1  - Yoshinobu, T.
A1  - Miyamoto, K.
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Semiconductor-based sensors for imaging of chemical processes
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 5
PB  - VDE-Verl.
CY  - Düsseldorf
ER  - 
TY  - THES
A1  - Werner, Frederik
T1  - Development of light-addressable potentiometric sensor systems and their applications in biotechnological environments
Y1  - 2014
N1  - Marburg, Univ., Diss., 2014
ER  - 
TY  - JOUR
A1  - Wang, Ren-Qi
A1  - Druckenmüller, Katharina
A1  - Elbers, Gereon
A1  - Guenther, Klaus
A1  - Croué, Jean-Philippe
T1  - Analysis of aquatic-phase natural organic matter by optimized LDI-MS method
JF  - Journal of mass spectrometry
N2  - The composition and physiochemical properties of aquatic-phase natural organic matter (NOM) are most important problems for both environmental studies and water industry. Laser desorption/ionization (LDI) mass spectrometry facilitated successful examinations of NOM, as humic and fulvic acids in NOM are readily ionized by the nitrogen laser. In this study, hydrophobic NOMs (HPO NOMs) from river, reservoir and waste water were characterized by this technique. The effect of analytical variables like concentration, solvent composition and laser energy was investigated. The exact masses of small molecular NOM moieties in the range of 200–1200 m/z were determined in reflectron mode. In addition, spectra of post-source-decay experiments in this range showed that some compounds from different natural NOMs had the same fragmental ions. In the large mass range of 1200–15 000 Da, macromolecules and their aggregates were found in HPO NOMs from natural waters. Highly humic HPO exhibited mass peaks larger than 8000 Da. On the other hand, the waste water and reservoir water mainly had relatively smaller molecules of about 2000 Da. The LDI-MS measurements indicated that highly humic river waters were able to form large aggregates and membrane foulants, while the HPO NOMs from waste water and reservoir water were unlikely to form large aggregates. Copyright © 2014 John Wiley & Sons, Ltd.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/jms.3321
SN  - 1096-9888
VL  - 49
IS  - 2
SP  - 154
EP  - 160
PB  - Wiley
CY  - Bognor Regis
ER  - 
TY  - JOUR
A1  - Wallenborn, Ramona
A1  - Ritz, Thomas
T1  - Mobilität miteinander teilen : städtisches eCarsharing in einer vernetzten Gesellschaft ; [vernetztes Fahren von morgen]
JF  - Neue Mobilität : das Magazin vom Bundesverband eMobilität
Y1  - 2014
SN  - 2191-5636
VL  - 5
IS  - 14 (Herbstausg.)
SP  - 92
EP  - 95
PB  - Bundesverband eMobilität BEM
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wagner, Patrick
A1  - Doll, Theodor
A1  - Schöning, Michael Josef
T1  - Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Schöning (eds.)
JF  - Physica status solidi (A) : Applications and materials science
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201470241
SN  - 1521-396X (E-Book); 1862-6319 (E-Book); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1339
EP  - 1339
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Vos, E. K.
A1  - Lagemaat, M. W.
A1  - Barentsz, J. O.
A1  - Fütterer, J. J.
A1  - Zamecnik, P.
A1  - Roozen, H.
A1  - Orzada, S.
A1  - Bitz, Andreas
A1  - Maas, M. C.
A1  - Scheenen, T. W. J.
T1  - Image quality and cancer visibility of T2-weighted Magnetic Resonance Imaging of the prostate at 7 Tesla
JF  - European Radiology
N2  - Objectives
To assess the image quality of T2-weighted (T2w) magnetic resonance imaging of the prostate and the visibility of prostate cancer at 7 Tesla (T).

Materials & methods
Seventeen prostate cancer patients underwent T2w imaging at 7T with only an external transmit/receive array coil. Three radiologists independently scored images for image quality, visibility of anatomical structures, and presence of artefacts. Krippendorff’s alpha and weighted kappa statistics were used to assess inter-observer agreement. Visibility of prostate cancer lesions was assessed by directly linking the T2w images to the confirmed location of prostate cancer on histopathology.

Results
T2w imaging at 7T was achievable with ‘satisfactory’ (3/5) to ‘good’ (4/5) quality. Visibility of anatomical structures was predominantly scored as ‘satisfactory’ (3/5) and ‘good’ (4/5). If artefacts were present, they were mostly motion artefacts and, to a lesser extent, aliasing artefacts and noise. Krippendorff’s analysis revealed an α = 0.44 between three readers for the overall image quality scores. Clinically significant cancer lesions in both peripheral zone and transition zone were visible at 7T.

Conclusion
T2w imaging with satisfactory to good quality can be routinely acquired, and cancer lesions were visible in patients with prostate cancer at 7T using only an external transmit/receive body array coil.
Y1  - 2014
U6  - http://dx.doi.org/10.1007/s00330-014-3234-6
SN  - 1432-1084
VL  - 24
IS  - 8
SP  - 1950
EP  - 1958
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Voronkova, Eva B.
A1  - Bauer, Svetlana M.
A1  - Kotliar, Konstantin
T1  - Computer simulation of the cornea-scleral shell as applied to pressure-volume relationship in the human eye
T2  - 2014 International Conference on Computer Technologies in Physical and Engineering Applications :  ICCTPEA 2014 : proceedings : June 30 2014-July 4 2014, St. Petersburg
Y1  - 2014
SN  - 978-1-4799-5315-8
SP  - 204
EP  - 205
ER  - 
TY  - JOUR
A1  - Vogt, C.
A1  - Mottaghy, Darius
A1  - Rath, V.
A1  - Marquart, G.
A1  - Dijkshoorn, L.
A1  - Wolf, A.
A1  - Clauser, C.
T1  - Vertical variation in heat flow on the Kola Peninsula: palaeoclimate or fluid flow?
JF  - Geophysical Journal International
N2  - Following earlier studies, we present forward and inverse simulations of heat and fluid transport of the upper crust using a local 3-D model of the Kola area. We provide best estimates for palaeotemperatures and permeabilities, their errors and their dependencies. Our results allow discriminating between the two mentioned processes to a certain extent, partly resolving the non-uniqueness of the problem. We find clear indications for a significant contribution of advective heat transport, which, in turn, imply only slightly lower ground surface temperatures during the last glacial maximum relative to the present value. These findings are consistent with the general background knowledge of (i) the fracture zones and the corresponding fluid movements in the bedrock and (ii) the glacial history of the Kola area.
Y1  - 2014
U6  - http://dx.doi.org/10.1093/gji/ggu282
SN  - 1365-246X
VL  - 199
IS  - 2
SP  - 829
EP  - 843
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Verschitz, Daniel
A1  - Butenweg, Christoph
T1  - Standsicherheitsnachweis von Behältern für Kleinkläranlagen
JF  - ACWA aktuell
N2  - Die PIA GmbH prüft seit fast 8 Jahren die Standsicherheit von Behältern für Kleinkläranlagen. Diese bestehen in der Regel aus Kunststoff oder Beton und müssen über ihre gesamte Lebensdauer den Beanspruchungen aus Handhabung, Einbau und Betrieb standhalten. Die Standsicherheit kann nach EN 12566 wahlweise durch einen rechnerischen Nachweis oder durch einen praktischen Nachweis wie die Bruchlastprüfung oder die Prüfung in der Grube erfolgen.
Y1  - 2014
IS  - 12 - 9/2014
SP  - 10
PB  - RWTH Aachen
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Turaliyeva, M.
A1  - Yeshibaev, A.
A1  - Digel, Ilya
A1  - Elibayeva, G.
A1  - Sydykova, A.
A1  - Uspabayeva, A.
A1  - Dosybayeva, G.
A1  - Zhylysbayeva, A.
A1  - Lakhanova, K.
T1  - Molecular-genetic identification of emerged novel invasive pathogens of Asiatic Elm Ulmus pumila L
JF  - Life science journal
N2  - The dwarf elm Ulmus pumila L. (Ulmaceae) is one of indigenous species of flora in Kazakhstan and forms a basis of dendroflora in virtually all settlements of the region. In the past decade, multiple outbreaks of previously unknown diseases of the small-leaved elm have been registered. In our study, by the molecular-genetic analysis it was found that the pathogens responsible for the outbreaks are microfungi belonging to the genus Fusarium – F. solani and F. oxysporum. The nucleotide sequences (ITS regions) isolated from the diseased trees showed very high similarity with the GenBank control numbers EU625403.1 and FJ478128.1 (100.0 and 99.0 % respectively). Oncoming research will focus on the search of natural microbial antagonists of the discovered phytopathogens.
Y1  - 2014
U6  - http://dx.doi.org/10.7537/marslsj1105s14.33
SN  - 1097-8135
VL  - 11
IS  - Spec. iss. 5s
SP  - 171
EP  - 175
PB  - Marsland Press
CY  - New York
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
T1  - Shakedown analysis of Reissner-Mindlin plates using the edge-based smoothed finite element method
T2  - Direct methods for limit states in structures and materials / Dieter Weichert ; Alan Ponter, ed.
N2  - This paper concerns the development of a primal-dual algorithm for limit and shakedown analysis of Reissner-Mindlin plates made of von Mises material. At each optimization iteration, the lower bound of the shakedown load multiplier is calculated simultaneously with the upper bound using the duality theory. An edge-based smoothed finite element method (ES-FEM) combined with the discrete shear gap (DSG) technique is used to improve the accuracy of the solutions and to avoid the transverse shear locking behaviour. The method not only possesses all inherent features of convergence and accuracy from ES-FEM, but also ensures that the total number of variables in the optimization problem is kept to a minimum compared with the standard finite element formulation. Numerical examples are presented to demonstrate the effectiveness of the present method.
Y1  - 2014
SN  - 978-94-007-6826-0 (Print) 978-94-007-6827-7 (Online)
U6  - http://dx.doi.org/10.1007/978-94-007-6827-7_5
SP  - 101
EP  - 117
PB  - Springer
CY  - Dordrecht [u.a.]
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
ED  - Onate, E.
T1  - Uncertain multimode failure and limit analysis of shells
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - CHAP
A1  - Tran, Ngoc Trinh
A1  - Staat, Manfred
A1  - Stavroulakis, G. E.
ED  - Onate, E.
T1  - A multicriteria method for truss optimization
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - JOUR
A1  - Tran, Duc Hung
T1  - Multiple corporate governance attributes and the cost of capital – Evidence from Germany
JF  - The British Accounting Review
N2  - This paper investigates the extent to which corporate governance affects the cost of debt and equity capital of German exchange-listed companies. I examine corporate governance along three dimensions: financial information quality, ownership structure and board structure. The results suggest that firms with high levels of financial transparency and bonus compensations face lower cost of equity. In addition, block ownership is negatively related to firms' cost of equity when the blockholders are other firms, managers or founding-family members. Consistent with the conjecture that agency costs increase with firm size, I find significant cost of debt effects only in the largest German companies. Here, the creditors demand lower cost of debt from firms with block ownerships held by corporations or banks. My findings demonstrate that a uniform set of governance attributes is unlikely to satisfy suppliers of debt and equity capital equally.
Y1  - 2018
U6  - http://dx.doi.org/https://doi.org/10.1016/j.bar.2014.02.003
SN  - 0890-8389
VL  - 46
IS  - 2
SP  - 179
EP  - 197
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Wollny, Steffen
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - Recycling of spent oil bleaching earth as source of glycerol for the anaerobic production of acetone, butanol, and ethanol with Clostridium diolis and lipolytic Clostridium lundense
JF  - Engineering in Life Sciences
N2  - A major part of edible oil is subjected to bleaching procedures, primarily with minerals applied as adsorbers. Their recycling is currently done either by regaining the oil via organic solvent extraction or by using the spent bleaching earth (SBE) as additive for animal feed, etc. As a new method, the reutilization of the by-product SBE for the microbiologic formation of acetone, butanol, and ethanol (ABE) is presented as proof-of-concept. The SBE was taken from a palm oil cleaning process. The recycling concept is based on the application of lipolytic clostridia strains. Due to considerably long fermentation times, co-fermentation with Candida rugosa and enzymatic hydrolyses of the bound oil with a subsequent clostridia fermentation are shown as alternative routes. Anaerobic fermentations under comparison of different clostridia strains were performed with glycerol media, enzymatically hydrolyzed palm oil and SBE. Solutes, side product compositions and productivities were quantified via HPLC. A successful production of ABE solutes from SBE has been done with a yield of 0.15 g butanol per gram of bound glycerol. Thus, the biotechnological recycling of the waste stream is possible in principle. Inhibition of the substrate suspension has been observed. A chromatographic ion-exchange of substrates increased the biomass concentration.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/elsc.201300113
SN  - 1618-2863
VL  - 14
IS  - 4
SP  - 425
EP  - 432
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Duwe, Anna-Maria
A1  - Wiesen, Sebastian
A1  - Sieker, Tim
A1  - Ulber, Roland
T1  - Enzymatic hydrolysis of beech wood lignocellulose at high solid contents and its utilization as substrate for the production of biobutanol and dicarboxylic acids
JF  - Bioresource Technology
N2  - The development of a cost-effective hydrolysis for crude cellulose is an essential part of biorefinery developments. To establish such high solid hydrolysis, a new solid state reactor with static mixing is used. However, concentrations >10% (w/w) cause a rate and yield reduction of enzymatic hydrolysis. By optimizing the synergetic activity of cellulolytic enzymes at solid concentrations of 9%, 17% and 23% (w/w) of crude Organosolv cellulose, glucose concentrations of 57, 113 and 152 g L⁻¹ are reached. However, the glucose yield decreases from 0.81 to 0.72gg⁻¹ at 17% (w/w). Optimal conditions for hydrolysis scale-up under minimal enzyme addition are identified. As result, at 23% (w/w) crude cellulose the glucose yield increases from 0.29 to 0.49gg⁻¹. As proof of its applicability, biobutanol, succinic and itaconic acid are produced with the crude hydrolysate. The potential of the substrate is proven e.g. by a high butanol yield of 0.33gg⁻¹.
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.biortech.2014.06.052
VL  - 167
SP  - 447
EP  - 455
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Timme, Michael
T1  - Wohnungseigentümergemeinschaft - Einstimmigkeitserfordernis bei Errichtung einer Mobilfunkantenne
JF  - Monatsschrift für Deutsches Recht : MDR : Zeitschrift für die Zivilrechts-Praxis
N2  - Der BGH (BGH v. 25.1.2014 – V ZR 48/13, MDR 2014, 399) hatte darüber zu befinden, ob auf dem Dach eines Hauses, das im Eigentum einer Wohnungseigentümergemeinschaft steht, auch gegen den Willen eines einzelnen Eigentümers eine Mobilfunkantenne angebracht werden kann. Das Urteil führt in das Spannungsfeld einer Abwägung zwischen Mehrheits- und Individualinteressen innerhalb einer WEG. Insoweit betont der BGH den grundsätzlichen Vorrang der Individualinteressen, jedenfalls soweit es um Beeinträchtigungen geht, die verständlicherweise von einem Eigentümer abgelehnt werden können. Der BGH verlangt im Ergebnis im Zweifel eine allseitige Zustimmung. Das Urteil ist zu begrüßen, lässt aber für die Zukunft Abgrenzungsfragen offen.
Y1  - 2014
SN  - 0340-1812
VL  - 68 (2014)
IS  - 11
SP  - 634
EP  - 635
PB  - Verlag Dr. Otto Schmidt
CY  - Köln
ER  - 
TY  - BOOK
A1  - Timme, Michael
T1  - Wohnungseigentumsgesetz : Gesetz über das Wohnungseigentum und das Dauerwohnrecht; Kommentar / Timme [Hrsg.]
Y1  - 2014
SN  - 978-3-406-66025-2
PB  - Beck
CY  - München
ET  - 2. Aufl.
ER  - 
TY  - JOUR
A1  - Timme, Michael
T1  - BGH: Geltendmachung von Sachmängeln bei Wohnungseigentum
JF  - LMK : Fachdienst Zivilrecht : Kommentierte BGH-Rechtsprechung
Y1  - 2014
SN  - 1611-1095
N1  - Kostenlose Registrierung erforderlich
VL  - 2014
IS  - 5
PB  - Beck
CY  - München
ER  - 
TY  - CHAP
A1  - Timme, Michael
T1  - Begriffsbestimmungen
T2  - Wohnungseigentumsgesetz : Gesetz über das Wohnungseigentum und das Dauerwohnrecht ; Kommentar
Y1  - 2014
SN  - 978-3-406-66025-2
SP  - 1
EP  - 23
PB  - Beck
CY  - München
ET  - 2. Auflage
ER  - 
TY  - BOOK
A1  - Tietze, Jürgen
T1  - Einführung in die angewandte Wirtschaftsmathematik : das praxisnahe Lehrbuch - inklusive Brückenkurs für Einsteiger. - 17. erw. Aufl.
Y1  - 2014
SN  - 978-3-658-02361-4  ; 978-3-658-02360-7
PB  - Springer
CY  - Wiesbaden
ET  - 17., erw. Aufl.
ER  - 
TY  - BOOK
A1  - Tietze, Jürgen
T1  - Übungsbuch zur angewandten Wirtschaftsmathematik : Aufgaben, Testklausuren und ausführliche Lösungen. -  9., überarb. u. erw. Aufl.
Y1  - 2014
SN  - 978-3-658-06874-5 ; 978-3-658-06873-8
PB  - Vieweg + Teubner
CY  - Wiesbaden
ET  - 9., überarb. u. erw. Aufl.
ER  - 
TY  - JOUR
A1  - Thomas, Axel
A1  - Wassenberg, Gerd
T1  - Erfolgreich sein im Kampf um die besten Talente : Employer Branding
JF  - Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen
Y1  - 2014
N1  - Nur noch nach Anfrage bei der IHK Aachen erhältlich: https://www.ihk.de/aachen/servicemarken/presse/medien-der-ihk/wirtschaftliche-nachrichten/aktuelle-ausgaben
PB  - IHK Aachen
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Thomas, Axel
T1  - Generation Y
JF  - P.T. : Magazin für Wirtschaft und Gesellschaft
Y1  - 2014
SN  - 1860-501X
VL  - 10
IS  - 3
SP  - 6
EP  - 9
PB  - OPS Netzwerk
CY  - Leipzig
ER  - 
TY  - JOUR
A1  - Theysohn, Jens M.
A1  - Kraff, Oliver
A1  - Eilers, Kristina
A1  - Andrade, Dorian
A1  - Gerwig, Marcus
A1  - Timmann, Dagmar
A1  - Schmitt, Franz
A1  - Ladd, Mark E.
A1  - Ladd, Susanne C.
A1  - Bitz, Andreas
T1  - Vestibular effects of a 7 Tesla MRI examination compared to 1.5 T and 0 T in healthy volunteers
JF  - PLoS one
N2  - Ultra-high-field MRI (7 Tesla (T) and above) elicits more temporary side-effects compared to 1.5 T and 3 T, e.g. dizziness or “postural instability” even after exiting the scanner. The current study aims to assess quantitatively vestibular performance before and after exposure to different MRI scenarios at 7 T, 1.5 T and 0 T. Sway path and body axis rotation (Unterberger's stepping test) were quantitatively recorded in a total of 46 volunteers before, 2 minutes after, and 15 minutes after different exposure scenarios: 7 T head MRI (n = 27), 7 T no RF (n = 22), 7 T only B₀ (n = 20), 7 T in & out B₀ (n = 20), 1.5 T no RF (n = 20), 0 T (n = 15). All exposure scenarios lasted 30 minutes except for brief one minute exposure in 7 T in & out B₀. Both measures were documented utilizing a 3D ultrasound system. During sway path evaluation, the experiment was repeated with eyes both open and closed. Sway paths for all long-lasting 7 T scenarios (normal, no RF, only B₀) with eyes closed were significantly prolonged 2 minutes after exiting the scanner, normalizing after 15 minutes. Brief exposure to 7 T B₀ or 30 minutes exposure to 1.5 T or 0 T did not show significant changes. End positions after Unterberger's stepping test were significantly changed counter-clockwise after all 7 T scenarios, including the brief in & out B₀ exposure. Shorter exposure resulted in a smaller alteration angle. In contrast to sway path, reversal of changes in body axis rotation was incomplete after 15 minutes. 1.5 T caused no rotational changes. The results show that exposure to the 7 Tesla static magnetic field causes only a temporary dysfunction or “over-compensation” of the vestibular system not measurable at 1.5 or 0 Tesla. Radiofrequency fields, gradient switching, and orthostatic dysregulation do not seem to play a role.
Y1  - 2014
U6  - http://dx.doi.org/10.1371/journal.pone.0092104
SN  - 1932-6203
VL  - 9
IS  - 3
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Takenaga, Shoko
A1  - Biselli, Manfred
A1  - Schnitzler, Thomas
A1  - Öhlschläger, Peter
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis–Menten-like kinetics for cell culturing
JF  - Physica status solidi A : Applications and materials science
N2  - The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17–200 mM) follows a Michaelis–Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201330464
SN  - 1521-396X (E); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1410
EP  - 1415
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
T1  - From the attempt of certain classical reformulations of quantum mechanics to quasi-probability representations
JF  - Journal of Mathematical Physics
N2  - The concept of an injective affine embedding of the quantum states into a set of classical states, i.e., into the set of the probability measures on some measurable space, as well as its relation to statistically complete observables is revisited, and its limitation in view of a classical reformulation of the statistical scheme of quantum mechanics is discussed. In particular, on the basis of a theorem concerning a non-denseness property of a set of coexistent effects, it is shown that an injective classical embedding of the quantum states cannot be supplemented by an at least approximate classical description of the quantum mechanical effects. As an alternative approach, the concept of quasi-probability representations of quantum mechanics is considered.
Y1  - 2014
U6  - http://dx.doi.org/10.1063/1.4861939
SN  - 222-488
N1  - bereits unter gleichem Titel aufgenommen bei arxiv : http://arxiv.org/pdf/1307.2314.pdf
VL  - 55
IS  - 1
PB  - AIP Publishing
CY  - College Park, Md.
ER  - 
TY  - JOUR
A1  - Stadler, Alexander Maximilian
A1  - Garvey, Christopher J.
A1  - Embs, Jan Peter
A1  - Koza, Michael Marek
A1  - Unruh, Tobias
A1  - Artmann, Gerhard
A1  - Zaccai, Guiseppe
T1  - Picosecond dynamics in haemoglobin from different species: A quasielastic neutron scattering study
JF  - Biochimica et biophysica acta (BBA): General Subjects
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.bbagen.2014.06.007
SN  - 1872-8006 (E-Journal); 0304-4165 (Print)
VL  - 1840
IS  - 10
SP  - 2989
EP  - 2999
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Srivastava, A.
A1  - Lahiri, S.
A1  - Maiti, M.
A1  - Knolle, F.
A1  - Hoyler, Friedrich
A1  - Scherer, Ulrich W.
A1  - Schnug, E. W.
T1  - Study of naturally occurring radioactive material (NORM) in top soil of Punjab State from the North Western part of India
JF  - Journal of Radioanalytical and Nuclear Chemistry
Y1  - 2014
U6  - http://dx.doi.org/0.1007/s10967-014-3450-1
SN  - 1588-2780 (E-Journal); 0022-4081 (Print); 0134-0719 (Print); 0236-5731 (Print); 1417-2097 (Print)
VL  - 2014
IS  - 302
SP  - 1049
EP  - 1052
PB  - Springer Nature
CY  - Basel
ER  - 
TY  - JOUR
A1  - Siqueira, Jose R.
A1  - Molinnus, Denise
A1  - Beging, Stefan
A1  - Schöning, Michael Josef
T1  - Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection
JF  - Analytical chemistry
N2  - The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor’s surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance–voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform.
Y1  - 2014
U6  - http://dx.doi.org/10.1021/ac500458s
SN  - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)
VL  - 86
IS  - 11
SP  - 5370
EP  - 5375
PB  - ACS Publications
CY  - Columbus
ER  - 
TY  - JOUR
A1  - Sillius, Sarah
T1  - „Viele machen gutes Marketing, ohne es zu wissen“ : zwei Experten von FH [Prof. Dr. Gert Hoepner] und RWTH Aachen [Prof. Dr. Daniel Mentzel] erklären, wie Unternehmen ihre Zielgruppe besser erreichen
JF  - Wirtschaftliche Nachrichten : das Magazin für Unternehmen / Industrie- und Handelskammer Aachen
Y1  - 2014
N1  - Nur noch nach Anfrage bei der IHK Aachen erhältlich: https://www.ihk.de/aachen/servicemarken/presse/medien-der-ihk/wirtschaftliche-nachrichten/aktuelle-ausgaben
VL  - 2014
IS  - 3
SP  - 16
EP  - 18
PB  - IHK Aachen
CY  - Aachen
ER  - 
TY  - BOOK
A1  - Siedenbiedel, Georg
T1  - Corporate Compliance : Grundelemente der strukturellen Integration von Compliance-Konzepten
Y1  - 2014
SN  - 3-482-65131-0
SN  - 978-3-482-65131-1
PB  - NWB-Verl.
CY  - Herne
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Glück, Olaf
A1  - Thust, Marion
T1  - Electrochemical composition measurement
T2  - Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen
Y1  - 2014
SN  - 978-1-4398-4891-3
SP  - 55-1
EP  - 55-54
PB  - CRC Pr.
CY  - Boca Raton, Fa.
ET  - 2nd ed.
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Glück, Olaf
A1  - Thust, Marion
T1  - Electrochemical methods for the determination of chemical variables in aqueous media
T2  - Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement
Y1  - 2014
SN  - 978-1-4398-4891-3
SP  - 55-1
EP  - 55-54
PB  - CRC Pr.
CY  - Boca Raton, Fla.
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Bäcker, Matthias
A1  - Krischer, M.
A1  - Wenzel, L.
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor
JF  - Procedia Engineering
N2  - A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers.
KW  - Field-effect sensor
KW  - enzymatic (bio)degradation
KW  - poly(d, l-lactic acid)
KW  - in-situ monitoring
KW  - impedance spectroscopy
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.proeng.2014.11.689
SN  - 1877-7058
N1  - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014>
VL  - 87
SP  - 1314
EP  - 1317
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - BOOK
A1  - Schulte-Zurhausen, Manfred
T1  - Organisation
Y1  - 2014
SN  - 978-3-8006-4689-0
PB  - Vahlen
CY  - München
ET  - 6., überarb. und aktualisierte Aufl.
ER  - 
TY  - JOUR
A1  - Schroeter, Rebecca
A1  - Hoffmann, Tamara
A1  - Voigt, Birgit
A1  - Meyer, Hanna
A1  - Bleisteiner, Monika
A1  - Muntel, Jan
A1  - Jürgen, Britta
A1  - Albrecht, Dirk
A1  - Becher, Dörte
A1  - Lalk, Michael
A1  - Evers, Stefan
A1  - Bongaerts, Johannes
A1  - Maurer, Karl-Heinz
A1  - Putzer, Harald
A1  - Hecker, Michael
A1  - Schweder, Thomas
A1  - Bremer, Erhard
T1  - Stress responses of the industrial workhorse Bacillus licheniformis to osmotic challenges
JF  - PLoS ONE
N2  - The Gram-positive endospore-forming bacterium Bacillus licheniformis can be found widely in nature and it is exploited in industrial processes for the manufacturing of antibiotics, specialty chemicals, and enzymes. Both in its varied natural habitats and in industrial settings, B. licheniformis cells will be exposed to increases in the external osmolarity, conditions that trigger water efflux, impair turgor, cause the cessation of growth, and negatively affect the productivity of cell factories in biotechnological processes. We have taken here both systems-wide and targeted physiological approaches to unravel the core of the osmostress responses of B. licheniformis. Cells were suddenly subjected to an osmotic upshift of considerable magnitude (with 1 M NaCl), and their transcriptional profile was then recorded in a time-resolved fashion on a genome-wide scale. A bioinformatics cluster analysis was used to group the osmotically up-regulated genes into categories that are functionally associated with the synthesis and import of osmostress-relieving compounds (compatible solutes), the SigB-controlled general stress response, and genes whose functional annotation suggests that salt stress triggers secondary oxidative stress responses in B. licheniformis. The data set focusing on the transcriptional profile of B. licheniformis was enriched by proteomics aimed at identifying those proteins that were accumulated by the cells through increased biosynthesis in response to osmotic stress. Furthermore, these global approaches were augmented by a set of experiments that addressed the synthesis of the compatible solutes proline and glycine betaine and assessed the growth-enhancing effects of various osmoprotectants. Combined, our data provide a blueprint of the cellular adjustment processes of B. licheniformis to both sudden and sustained osmotic stress.
Y1  - 2014
U6  - http://dx.doi.org/10.1371/journal.pone.0080956
SN  - 1932-6203
VL  - 8
IS  - 11
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - CHAP
A1  - Schreiber, Marc
A1  - Barkschat, Kai
A1  - Kraft, Bodo
T1  - Using Continuous Integration to organize and monitor the annotation process of domain specific corpora
T2  - 5th International Conference on Information and Communication Systems (ICICS) : 1-3 April 2014, Irbid, Jordanien
Y1  - 2014
SN  - 978-1-4799-3022-7
U6  - http://dx.doi.org/10.1109/IACS.2014.6841958
SP  - 1
EP  - 6
ER  - 
TY  - CHAP
A1  - Schopp, Christoph
A1  - Heuermann, Holger
A1  - Holtrup, S.
T1  - Investigation on efficacy optimization of RF-driven automotive D-lamps
T2  - 44th European Microwave Conference (EuMC),2014, Rome
Y1  - 2014
U6  - http://dx.doi.org/10.1109/EuMC.2014.6986645
SP  - 1154
EP  - 1157
ER  - 
TY  - BOOK
A1  - Schneider, Bettina
A1  - Schneider, Wilhelm
T1  - Jahresabschluss und Jahresabschlussanalyse : systematische Darstellung in Übersichten. (Reihe Betriebswirtschaftslehre in Übersichten ; 2)
Y1  - 2014
SN  - 978-3–95404–828–1
PB  - Cuvillier
CY  - Göttingen
ET  - 5. Aufl., Studienausg.
ER  - 
TY  - CHAP
A1  - Schmidt, Herbert
T1  - Angst vor Zukunft, Lust auf Zukunft
T2  - Re|peat-Jahrbuch Treasury und Private Banking : Produkte, Märkte und Strategien zum Nachschlagen und Verstehen
Y1  - 2014
SP  - 255
EP  - 269
PB  - Roland Eller
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Schirra, Julian
A1  - Watmuff, Jonathan
A1  - Bauschat, J.-Michael
T1  - Highly non-planar lifting systems: a relative assessment of existing potential-methodologies to accurately estimate the induced drag
JF  - 32nd  AIAA Applied Aerodynamics Conference 2014 : June, 16-20 2014, Atlanta, Ga.
Y1  - 2014
SN  - 978-1-62410-288-2
U6  - http://dx.doi.org/10.2514/6.2014-2988
SP  - Publ. online
ER  - 
TY  - CHAP
A1  - Schirra, Julian
A1  - Watmuff, Jon
A1  - Bauschat, J.-Michael
T1  - A relative assessment of existing potential-methodologies to accurately estimate the induced drag of highly non-planar lifting systems
T2  - Advanced aero concepts, design and operations : Applied Aerodynamics Conference  : July 22 -24, 2014, Bristol, UK
Y1  - 2014
SP  - 1
EP  - 13
ER  - 
TY  - CHAP
A1  - Schirra, Julian
A1  - Bauschat, J.-Michael
A1  - Watmuff, J.H.
T1  - Accurate induced drag prediction for highly non-planar lifting systems
T2  - 19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia
N2  - The impact of wake model effects is investigated for two highly
non-planar lifting systems. Dependent on the geometrical
arrangement of the configuration, the wake model shape is found
to considerably affect the estimation. Particularly at higher angles
of attack, an accurate estimation based on the common linear wake
model approaches is involved.
Y1  - 2014
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications
JF  - Xenobiotica
N2  - 1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug–drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described.

2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created.

3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug–drug interactions as well as in human metabolite testing and risk assessment.

4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.
KW  - transporters
KW  - human metabolites
KW  - drug metabolising enzymes
KW  - drug–drug interactions
KW  - bioavailability
Y1  - 2014
U6  - http://dx.doi.org/10.3109/00498254.2013.815831
SN  - 1366-5928
VL  - 44
IS  - 2
SP  - 96
EP  - 108
PB  - Taylor & Francis
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Mclaughlin, Lesley A.
A1  - Rode, Anja
A1  - MacLeod, Alastair Kenneth
A1  - Henderson, Colin J.
A1  - Wolf, Roland C.
T1  - Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism
JF  - Drug Metabolism and Disposition
N2  - In humans, 75% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15%) and larger livers (20%). Changes in hepatic morphology and a decreased blood glucose (30%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.
Y1  - 2014
U6  - http://dx.doi.org/10.1124/dmd.114.057885
SN  - 1521-009X
VL  - 42
IS  - 6
SP  - 1022
EP  - 1030
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Sawada, Kazuaki
A1  - Nakazawa, Hirokazu
A1  - Takenaga, Shoko
A1  - Hizawa, Takeshi
A1  - Futagawa, Masato
A1  - Dasai, Fumihiro
A1  - Sakurai, Takashi
A1  - Okumura, Koichi
A1  - Hattori, Toshiaki
A1  - Ishida, Makoto
T1  - Multimodal bioimage sensor
JF  - IEICE transactions on fundamentals of electronics, communidations and computer sciences
N2  - To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials.
Y1  - 2014
U6  - http://dx.doi.org/10.1587/transfun.E97.A.726
SN  - 0916-8508 (Print) ; 1745-1337 (Online)
VL  - E97-A (2014)
IS  - 3
SP  - 726
EP  - 733
PB  - IEICE
CY  - Tokyo
ER  - 
TY  - JOUR
A1  - Salpati, Laurent
A1  - Chu, Xiaoyan
A1  - Chen, Liangfu
A1  - Prasad, Bhagwat
A1  - Dallas, Shannon
A1  - Evers, Raymond
A1  - Mamaril-Fishman, Donna
A1  - Geier, Ethan G.
A1  - Kehler, Jonathan
A1  - Kunta, Jeevan
A1  - Mezler, Mario
A1  - Laplanche, Loic
A1  - Pang, Jodie
A1  - Soars, Matthew G.
A1  - Unadkat, Jashvant D.
A1  - van Waterschoot, Robert A.B.
A1  - Yabut, Jocelyn
A1  - Schinkel, Alfred H.
A1  - Scheer, Nico
A1  - Rode, Anja
T1  - Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins
JF  - Drug Metabolism and Disposition
N2  - Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography–tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.
Y1  - 2014
U6  - http://dx.doi.org/10.1124/dmd.114.057976
SN  - 1521-009X
VL  - 42
IS  - 8
SP  - 1301
EP  - 1313
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - CHAP
A1  - Rousseau, Alain
A1  - Kern, Alexander
T1  - How to deal with environmental risk in IEC 62305-2
T2  - 2014 International Conference on Lightning Protection (ICLP), Shanghai, China
N2  - The 2nd edition of the lightning risk management
standard (IEC 62305-2) considers structures, which may
endanger environment. In these cases, the loss is not limited to
the structure itself, which is valid for usual structures. In the past
(Edition 1) this danger was simply taken into account by a special
hazard factor, multiplying the existing risk for the structure with
a number. Now, in the edition 2, we add to the risk for the
structure itself a “second risk” due to the losses outside the
structure. The losses outside can be treated independently from
what occurs inside. This is a major advantage to analyze the risk
for sensitive structures, like chemical plants, nuclear plants, or
structures containing explosives, etc. In this paper, the existing
procedure given by the European version EN 62305-2 Ed.2 is
further developed and applied to a few structures.
Y1  - 2014
SP  - 521
EP  - 527
ER  - 
TY  - CHAP
A1  - Rosin, Julia
A1  - Kubalski, Thomas
A1  - Butenweg, Christoph
T1  - Seismic Design of cylindrical liquid storage tanks
T2  - Seismic design of industrial facilities : proceedings of the International Conference on Seismic Design of Industrial Facilities (SeDIF-Conference) ; [Aachen, 26. - 27. September 2013] / Chair of Structural Statics and Dynamics, RWTH Aachen. Sven Klinkel ..., ed.
Y1  - 2014
SN  - 978-3-658-02810-7 (E-Book) ; 978-3-658-02809-1 (Print)
U6  - http://dx.doi.org/10.1007/978-3-658-02810-7_36
SP  - 429
EP  - 440
PB  - Springer Vieweg
CY  - Wiesbaden
ER  - 
TY  - CHAP
A1  - Rosin, Julia
A1  - Henneböhl, Benedickt
A1  - Butenweg, Christoph
T1  - Global buckling analysis of cylindrical liquid storage tanks under earthquake loading
T2  - 2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6
Y1  - 2014
SN  - 978-1-5108-1021-1
SP  - 5270
EP  - 5281
PB  - Curran Associates, Inc.
CY  - Red Hook, NY
ER  - 
TY  - CHAP
A1  - Rosin, Julia
A1  - Butenweg, Christoph
T1  - Berechnungsansatz für basisisolierte Tankbauwerke
T2  - Berichte der Fachtagung Baustatik - Baupraxis 12 am 24. und 25. Februar 2014 an der Technischen Universität München / Hrsg. Kai-Uwe Bletzinger ...
Y1  - 2014
SN  - 978-3-00-041256-1
SP  - 103
EP  - 112
PB  - Lehrstuhl für Statik, Techn. Univ. München
CY  - München
ER  - 
TY  - CHAP
A1  - Rosin, Julia
A1  - Butenweg, Christoph
T1  - Seismic isolation of cylindrical liquid storage tanks
T2  - Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)
Y1  - 2014
SN  - 978-972-752-165-4
SP  - 3145
EP  - 3152
CY  - Porto
ER  - 
TY  - RPRT
A1  - Ritz, Thomas
A1  - Siekmann, Kirsten
A1  - Wallenborn, Ramona
T1  - 3D-Druck – Prozessmanagement für individualisierte Massenprodukte : Wie können Fertigungsdienstleister in die endkundengerichtete Produktion integriert werden? ; Info-Broschüre
N2  - Die Informationsbroschüre „3D-Druck – Prozessmanagement für individualisierte Massenprodukte“ richtet sich an 3D-Druckdienstleister, die additive Fertigungsverfahren (Additive Manufacturing) nutzen, sowie an IT-Dienstleister, die eine Plattform für den Datenaustausch und die Individualisierung anbieten.

Mit der additiven 3D-Drucktechnologie erfolgt die Fertigung von Produkten durch einen schichtweisen Aufbau. In dieser Broschüre werden mögliche Potenziale im Bereich der Herstellung mittels additiver Fertigungsverfahren aufgezeigt.
Y1  - 2014
PB  - eBusiness-Lotse
CY  - Aachen
ER  - 
TY  - RPRT
A1  - Ritz, Thomas
A1  - Siekmann, Kirsten
A1  - Wallenborn, Ramona
T1  - Anforderungen an die Gestaltung multimodaler Mobilitätsanwendungen : Potenziale für die IT-Branche bei der Organisation der verkehrsmittelübergreifenden Mobilität von morgen am Beispiel CarSharing und privater PKW ; Info-Broschüre
N2  - Die Informationsbroschüre „Anforderungen an die Gestaltung multimodaler Mobilitätsanwendungen“ richtet sich an IT-Dienstleister. In dieser Broschüre werden mögliche Potenziale im Bereich des allgemeinen Mobilitätsmanagements aufgezeigt. Automobilhersteller vernetzten sich zunehmend mit Technologie-Unternehmen. Es geht nicht nur um die besondere Entwicklung von spezieller Elektronik- und Softwarelösungen für Navigations- und Entertainmentsysteme oder auch Fahrassistenz-Systemen in modernen PKW, sondern um einen übergreifenden Design- und Interaktionsansatz für miteinander vernetzte Geräte.
Y1  - 2014
N1  - Mittelstand Digital
PB  - eBusiness-Lotse
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Ritz, Thomas
A1  - Pisarczyk, Rafael
A1  - Sachtleben, Johanna
A1  - Leßenich, Nina
T1  - Usability Engineering maßgeschneidert : Modellbaukasten zur Entwicklung gebrauchstauglicher mobiler Software
JF  - Wissenschaft trifft Praxis
Y1  - 2014
SN  - 2198-8544 (Print)
SN  - 2198-9362 (Online)
N1  - Der Link führt zum vollständigen Heft, der Artikel beginnt auf S.79.
VL  - 1
IS  - 1
SP  - 79
EP  - 88
PB  - Begleitforschung Mittelstand-Digital c/o WIK-Consult GmbH
CY  - Bad Honnef
ER  - 
TY  - CHAP
A1  - Ritz, Thomas
A1  - Izquierdo Tello, César
A1  - Damm, Sebastian
T1  - Connecting a pedelec to the cloud as basis for gamification in multi modal mobility planning
T2  - MobileCloud 2014 : 2nd IEEE International Conference on Mobile Cloud Computing, Services, and Engineering Oxford, United Kingdom 7-10 April 2014
Y1  - 2014
SN  - 978-1-4799-2504-9
U6  - http://dx.doi.org/10.1109/MobileCloud.2014.25
SP  - 101
EP  - 108
PB  - IEEE Service Center
CY  - Piscataway, NJ
ER  - 
TY  - VIDEO
A1  - Ritz, Thomas
T1  - Multiplattformentwicklung für mobile Informationssysteme : eine strategische Perspektive
T2  - Info-Veranstaltung Multiplattform-Entwicklung für mobile Anwendungen, Dezember 2013
Y1  - 2014
ER  - 
TY  - GEN
A1  - Ritz, Thomas
T1  - Multiplattformentwicklung für mobile Informationssysteme : eine strategische Perspektive ; [Vortragsfolien]
T2  - Info-Veranstaltung Multiplattform-Entwicklung für mobile Entwicklungen, Dezember 2013
Y1  - 2014
ER  - 
TY  - JOUR
A1  - Riedel, Marc
A1  - Kartchemnik, Julia
A1  - Schöning, Michael Josef
A1  - Lisdat, Fred
T1  - Impedimetric DNA detection – steps forward to sensorial application
JF  - Analytical chemistry
N2  - This study describes a label-free impedimetric sensor based on short ssDNA recognition elements for the detection of hybridization events. We concentrate on the elucidation of the influence of target length and recognition sequence position on the sensorial performance. The impedimetric measurements are performed in the presence of the redox system ferri-/ferrocyanide and show an increase in charge transfer resistance upon hybridization of ssDNA to the sensor surface. Investigations on the impedimetric signal stability demonstrate a clear influence of the buffers used during the sensor preparation and the choice of the passivating mercaptoalcanol compound. A stable sensor system has been developed, enabling a reproducible detection of 25mer target DNA in the low nanomolar range. After hybridization, a sensor regeneration can be reached with deionized water by adjustment of effective convection conditions, ensuring a sensor reusability. By investigations of longer targets with overhangs exposed to the solution, we can demonstrate applicability of the impedimetric detection for longer ssDNA. However, a decreasing charge transfer resistance change (ΔRct) is found by extending the overhang. As a strategy to increase the impedance change for longer target strands, the position of the recognition sequence can be designed in a way that a small overhang is exposed to the electrode surface. This is found to result in an increase in the relative Rct change. These results suggest that DNA and consequently negative charge near the electrode possess a larger impact on the impedimetric signal than DNA further away.
Y1  - 2014
U6  - http://dx.doi.org/10.1021/ac501800q
SN  - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)
VL  - 86 (2014)
IS  - 15
SP  - 7867
EP  - 7874
PB  - ACS Publications
CY  - Columbus
ER  - 
TY  - THES
A1  - Reyes Ochoa, Leonel
T1  - Engineering aspects of a parabolic trough collector field with direct steam generation and an organic rankine cycle
Y1  - 2014
N1  - Aachen, Fachhochsch., Masterarbeit, 2014
PB  - Fachhochschule Aachen
CY  - Aachen
ER  - 
TY  - CHAP
A1  - Reichert, Walter
T1  - Der Vertriebsingenieur: Ausbildung und Beruf
T2  - Berufsstart Technik : das Karriereportal für junge Akademiker ; Ingenieure, Naturwissenschaftler, Informatiker
Y1  - 2014
SP  - 456
EP  - 458
PB  - Resch
CY  - Großenkneten
ER  - 
TY  - JOUR
A1  - Raue, Markus
A1  - Wambach, M.
A1  - Glöggler, S.
A1  - Grefen, Dana
A1  - Kaufmann, R.
A1  - Abetz, C.
A1  - Georgopanos, P.
A1  - Handge, U. A.
A1  - Mang, Thomas
A1  - Blümich, B.
A1  - Abetz, V.
T1  - Investigation of historical hard rubber ornaments of Charles Goodyear
JF  - Macromolecular chemistry and physics
Y1  - 2014
SN  - 1022-1352
VL  - Vol. 215
IS  - No. 3
SP  - 245
EP  - 254
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Rau, Christoph
A1  - Alexopoulos, Spiros
A1  - Breitbach, Gerd
A1  - Hoffschmidt, Bernhard
A1  - Latzke, Markus
A1  - Sattler, Johannes, Christoph
T1  - Transient simulation of a solar-hybrid tower power plant with open volumetric receiver at the location Barstow
JF  - Energy procedia : proceedings of the SolarPACES 2013 International Conference
N2  - In this work the transient simulations of four hybrid solar tower power plant concepts with open-volumetric receiver technology for a location in Barstow-Daggett, USA, are presented. The open-volumetric receiver uses ambient air as heat transfer fluid and the hybridization is realized with a gas turbine. The Rankine cycle is heated by solar-heated air and/or by the gas turbine's flue gases. The plant can be operated in solar-only, hybrid parallel or combined cycle-only mode as well as in any intermediate load levels where the solar portion can vary between 0 to 100%.

The simulated plant is based on the configuration of a solar-hybrid power tower project, which is in planning for a site in Northern Algeria. The meteorological data for Barstow-Daggett was taken from the software meteonorm. The solar power tower simulation tool has been developed in the simulation environment MATLAB/Simulink and is validated.
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.egypro.2014.03.157
SN  - 1876-6102
VL  - 49
SP  - 1481
EP  - 1490
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ratke, Lorenz
A1  - Milow, Barbara
A1  - Lisinski, Susanne
A1  - Hoepfner, Sandra
T1  - On an effect of fine ceramic particles on the structure of aerogels
JF  - Microgravity science and technology
Y1  - 2014
U6  - http://dx.doi.org/10.1007/s12217-014-9380-2
SN  - 0938-0108 ; 1875-0494
VL  - 26
SP  - 103
EP  - 110
PB  - Springer Nature
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Rath, V.
A1  - Mottaghy, Darius
T1  - Klimainformation aus dem Untergrund?
JF  - Geographische Rundschau
Y1  - 2014
SN  - 0016-7460
VL  - 66
IS  - 7-8
SP  - 30
EP  - 36
PB  - Westermann
CY  - Braunschweig
ER  - 
TY  - RPRT
A1  - Rahier, Michael
A1  - Ritz, Thomas
A1  - Wallenborn, Ramona
T1  - Elektromobilität in einer vernetzten Welt : Potenziale für die IT-Branche bei der Organisation der Mobilität von morgen ; Info-Broschüre
N2  - Die Informationsbroschüre „Elektromobilität in einer vernetzten Welt“ richtet sich an IT-Dienstleister. In dieser Broschüre werden mögliche Potenziale im Bereich der Elektromobilität aufgezeigt. Die Mobilität der Zukunft ist eine interdisziplinäre Angelegenheit und kein reines Automotive-Thema mehr. Beispiele wie Mobilitätsmanagement, eCommerce und Individualisierung sind im Mobilitätsbereich für die IT-Branche relevant.
Y1  - 2014
PB  - eBusiness-Lotse
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Pyschny, D.
A1  - Döring, Bernd
A1  - Feldmann, M.
T1  - Ermittlung der thermischen Leistungsfähigkeit des neuartigen multifunktionalen Verbunddeckensystems InaDeck
JF  - Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen
Y1  - 2014
SN  - 0005-6650
N1  - Printausgabe in der Bibliothek Bayernallee vorhanden: 13 Z 049-2014
VL  - 89
IS  - 3
SP  - 116
EP  - 124
PB  - VDI Fachmedien
CY  - Düsseldorf
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Weiland, Maryam
A1  - Schöning, Michael Josef
ED  - Lvova, Larisa
ED  - Kirsanov, Dmitry
ED  - di Natale, Corrado
ED  - Legin, Audrey
T1  - Nanoplate field-effect capacitors: a new transducer structure for multiparameter (bio-)chemical sensing
T2  - Multisensor system for chemical analysis : materials and sensors
N2  - An array of electrically isolated nanoplate field-effect silicon-on-insulator (SOI) capacitors as a new transducer structure for multiparameter (bio-)chemical sensing is presented. The proposed approach allows addressable biasing and electrical readout of multiple nanoplate field-effect capacitive (bio-)chemical sensors on the same SOI chip, as well as differential-mode measurements. The realized sensor chip has been applied for pH and penicillin concentration measurements, electrical monitoring of polyelectrolyte multilayer formation, and the label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization and denaturation events.
Y1  - 2014
SN  - 978-981-4411-15-8 ; 978-981-4411-16-5
U6  - http://dx.doi.org/10.1201/b15491-11
SP  - 333
EP  - 373
PB  - Jenny Stanford Publishing
CY  - Singapore
ET  - 1
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Label-free sensing of biomolecules with field-effect devices for clinical applications
JF  - Electroanalysis
N2  - Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/elan.201400073
SN  - 1521-4109 (E-Journal); 1040-0397 (Print)
VL  - 26
IS  - 6
SP  - 1197
EP  - 1213
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - RPRT
A1  - Pisarczyk, Rafael
A1  - Ritz, Thomas
A1  - Wallenborn, Ramona
T1  - Unterschiedliche Entwicklungsansätze von Multiplattform-Anwendungen : Marktübersicht
N2  - Die Marktübersicht „Unterschiedliche Entwicklungsansätze von Multiplattform-Anwendungen“ richtet sich an IT-Dienstleister, Entwickler und IT-Abteilungen von Unternehmen, die Multiplattform Anwendungen entwickeln. In dieser Marktübersicht werden verschiedene Entwicklungsansätze beschrieben und ihre jeweiligen Vor- und Nachteile aufgezeigt.
Y1  - 2014
N1  - Mittelstand Digital
PB  - eBusiness-Lotse
CY  - Aachen
ER  - 
TY  - CHAP
A1  - Pieper, Martin
A1  - Schulz, Silvia
T1  - Teaching Simulation Methods with COMSOL Multiphysics
N2  - This paper describes two courses on
simulation methods for graduate students:
“Simulation Methods” and “Simulation and
Optimization in Virtual Engineering” The
courses were planned to teach young engineers
how to work with simulation software as well as
to understand the necessary mathematical background.
As simulation software COMSOL is
used. The main philosophy was to combine
theory and praxis in a way that motivates the
students. In addition “soft skills” should be
improved. This was achieved by project work as
final examination. As underlying didactical principle
the ideas of Bloom’s revised taxonomy
were followed. The paper basically focusses on
educational aspects, e.g. how to structure the
course, plan the exercises, organize the project
work and include practical COMSOL examples.
KW  - COMSOL Multiphysics
KW  - Optimization module
KW  - LiveLink for MATLAB
KW  - Bloom Taxonomy
KW  - education
Y1  - 2014
ER  - 
TY  - JOUR
A1  - Pham, Phu Tinh
A1  - Staat, Manfred
T1  - FEM-based shakedown analysis of hardening structures
JF  - Asia Pacific journal on computational engineering
N2  - This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature.
Y1  - 2014
U6  - http://dx.doi.org/10.1186/2196-1166-1-4
SN  - 2196-1166 (E-Journal)
IS  - 1
SP  - Article No. 4
PB  - SpringerOpen
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Pfaff, Raphael
A1  - Sappler, Magnus
T1  - TRANSPACT : die automatische Mittelpufferkupplung für attraktiven Güterverkehr
T2  - RAIL-FREIGHT 2014 : Zukunft des Schienengüterverkehrs ; Technologie - Ökonomie - Ökologie - Verkehrspolitik ; [Tagungsdokumentation des IV. Internationalen Fachsymposiums zum Thema Schienengüterverkehr] (Bahntechnik Aktuell ; 48)
Y1  - 2014
SN  - 978-3-940727-41-1
SP  - 121
EP  - 128
PB  - Verl. d. IFV Bahntechnik
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pasteur, Aline
A1  - Tippkötter, Nils
A1  - Kampeis, Percy
A1  - Ulber, Roland
T1  - Optimization of high gradient magnetic separation filter units for the purification of fermentation products
JF  - IEEE TRANSACTIONS ON MAGNETICS
N2  - High gradient magnetic separation (HGMS) has been established since the early 1970s. A more recent application of these systems is the use in bioprocesses. To integrate the HGMS in a fermentation process, it is necessary to optimize the separation matrix with regard to the magnetic separation characteristics and permeability of the non-magnetizable components of the fermentation broth. As part of the work presented here, a combined fluidic and magnetic force finite element model simulation was created using the software COMSOL Multiphysics and compared with separation experiments. Finally, as optimal lattice orientation of the separation matrix, a transversal rhombohedral arrangement was defined. The high suitability of the new filter matrix has been verified by separation experiments.
Y1  - 2014
U6  - http://dx.doi.org/10.1109/TMAG.2014.2325535
SN  - 0018-9464
N1  - Article Sequence Number: 5000607
INSPEC Accession Number: 14663042
VL  - 50
IS  - 10
SP  - Artikel 5000607
PB  - IEEE
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Olbertz, Klaus
T1  - Die arbeitsrechtliche Stellung des Prokuristen - Handelsrechtlicher Kompetenzzuwachs mit arbeitsrechtlichen Konsequenzen
JF  - NWB - Steuer- und Wirtschaftsrecht
N2  - Die Beschäftigung von Prokuristen ist gängige betriebliche Praxis. Unternehmen stehen dabei immer wieder vor der Frage, ob und welche Arbeitnehmer sie zu Prokuristen bestellen sollen. Nicht selten bleiben hierbei die arbeitsrechtlichen Konsequenzen, die mit der Bestellung eines Arbeitnehmers zum Prokuristen einhergehen können, unberücksichtigt, wie diverse Gerichtsentscheidungen zeigen. Dieser Beitrag soll einen Überblick über die arbeitsrechtlichen Folgen bei der Beschäftigung von Prokuristen geben und der betrieblichen Praxis somit gleichzeitig als Entscheidungshilfe dienen, wenn es um das Ob und Wie der möglichen Bestellung eines Arbeitnehmers zum Prokuristen geht.
Y1  - 2018
SN  - 1860-9449
IS  - 21
SP  - 1591
EP  - 1596
PB  - NWB-Verlag
CY  - Herne
ER  - 
TY  - JOUR
A1  - Olbertz, Klaus
T1  - Der neue gesetzliche Mindestlohn – was gilt und was Unternehmen künftig beachten müssen
JF  - Gesellschafts- und Wirtschaftsrecht : GWR
N2  - Ab dem 1.1.2015 ist es soweit: Deutschland erhält einen flächendeckenden und weitgehend branchenunabhängigen gesetzlichen Mindestlohn. Danach haben grundsätzlich alle abhängig beschäftigten Arbeitnehmer einen Anspruch auf eine Entlohnung von wenigstens 8,50 EUR brutto je Arbeitsstunde. Die Auswirkungen dürften enorm sein. Das Bundesministerium für Arbeit und Soziales geht jedenfalls davon aus, dass aufgrund der Einführung des gesetzlichen Mindestlohns mehrere Millionen Beschäftigte einen höheren Lohn beanspruchen können. Der nachfolgende Beitrag gibt einen Überblick über die wesentlichen Inhalte des gesetzlichen Mindestlohns und Hinweise für Anwendungsprobleme in der betrieblichen Praxis.
Y1  - 2018
SN  - 1868-1816
SP  - 521
EP  - 524
ER  - 
TY  - GEN
A1  - Olbertz, Klaus
T1  - Arbeitszeitbetrug rechtfertigt fristlose Kündigung auch bei langer Betriebszugehörigkeit
T2  - Gesellschafts- und Wirtschaftsrecht : GWR
Y1  - 2018
SN  - 1868-1816
N1  - Anm. zu LAG Hessen:
Entscheidungsbesprechung zum Urteil v. 17.02.2014 - 16 Sa 1299/13
SP  - 465
EP  - 465
ER  - 
TY  - JOUR
A1  - Olbertz, Klaus
T1  - Gestaltung des Anstellungsvertrags - Der Compliance-Beauftragte
JF  - Arbeit und Arbeitsrecht : AuA
N2  - Ein Compliance-Beauftragter soll dafür Sorge tragen, dass aus dem Unternehmen heraus keine Rechtsverletzungen begangen werden. Aber welche rechtlichen Notwendigkeiten und Möglichkeiten resultieren daraus für die Gestaltung des Anstellungsvertrags?
Y1  - 2014
SN  - 0323-4568
IS  - 7
SP  - 400
EP  - 403
PB  - Huss Medien
CY  - Berlin
ER  - 
TY  - GEN
A1  - Olbertz, Klaus
T1  - Vorbeschäftigungszeiten als Leiharbeitnehmer zählen für Kündigungsschutz grundsätzlich nicht mit
T2  - Gesellschafts- und Wirtschaftsrecht : GWR
Y1  - 2018
SN  - 1868-1816
N1  - Anm. zu BAG: Entscheidungsbesprechung zum Urteil v. 20.02.2014 - 2 AZR 859/11
SP  - 423
EP  - 423
ER  - 
TY  - GEN
A1  - Olbertz, Klaus
T1  - Kein Anspruch auf Tarifgehaltserhöhungen bei Kündigung des in Bezug genommenen Anerkennungstarifvertrags
T2  - Gesellschafts- und Wirtschaftsrecht : GWR
Y1  - 2018
SN  - 1868-1816
N1  - Anm. zu BAG: Entscheidungsbesprechung zum Urteil v. 11.12.2013 - 4 AZR 473/12
SP  - 377
EP  - 377
ER  - 
TY  - GEN
A1  - Olbertz, Klaus
T1  - Arbeitnehmereigenschaft des mitarbeitenden Gesellschafters einer GmbH
T2  - Gesellschafts- und Wirtschaftsrecht : GWR
Y1  - 2018
SN  - 1868-1816
N1  - Anm. zu BAG: Entscheidungsbesprechungzum Beschluss v. 17.09.2014 - 10 AZB 43/14
SP  - 532
EP  - 532
ER  - 
TY  - CHAP
A1  - Oertel, Mario
A1  - Bung, Daniel B.
T1  - Numerische Strömungssimulation von Fließgewässern - Wo stehen wir und was werden wir im Laufe der nächsten Jahre erreichen?
T2  - Simulationsverfahren und Modelle für Wasserbau und Wasserwirtschaft = Simulation techniques and models for hydraulic engineering and water management / 37. Dresdner Wasserbaukolloquium 2014, 13. - 14. März 2014. (Dresdner wasserbauliche Mitteilungen ; H. 50)
Y1  - 2014
SN  - 978-3-86780-349-6
SP  - 19
EP  - 30
ER  - 
TY  - CHAP
A1  - Oberländer, Jan
A1  - Kirchner, Patrick
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Flexible polyimide-based calorimetric gas sensors for monitoring hy-drogen peroxide in sterilisation processes of aseptic filling machines
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 4
PB  - VDE-Verl.
CY  - Düsseldorf
ER  -