TY  - JOUR
A1  - Hoehr, Cornelia
A1  - Paulßen, Elisabeth
A1  - Benard, Francois
A1  - Lee, Chris Jaeil
A1  - Hou, Xinchi
A1  - Badesso, Brian
A1  - Ferguson, Simon
A1  - Miao, Qing
A1  - Yang, Hua
A1  - Buckley, Ken
A1  - Hanemaayer, Victoire
A1  - Zeisler, Stefan
A1  - Ruth, Thomas
A1  - Celler, Anna
A1  - Schaffer, Paul
T1  - ⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron
JF  - Nuclear medicine and biology
N2  - Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.nucmedbio.2013.12.016
SN  - 1872-9614
VL  - 41
IS  - 5
SP  - 401
EP  - 406
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Groebel, Simone
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Selmer, Thorsten
A1  - Baumann, Marcus
A1  - Schöning, Michael Josef
T1  - Überwachung der metabolischen Aktivität von Mikroorganismen zur Kontrolle des biologischen Prozesses im Biogasfermenter
JF  - Biogas 2011 : Energieträger der Zukunft ; 6. Fachtagung, Fachtagung Braunschweig, 08. und 09. Juni 2011 / VDI Energie und Umwelt
Y1  - 2011
SN  - 978-3-18-092121-1
N1  - Gesellschaft Energie und Umwelt ; Fachtagung Biogas ; (6 : ; 2011.06.08-09 : ; Braunschweig) ; 	VDI-Berichte ; 2121
SP  - 285
EP  - 286
PB  - VDI-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Haulena, Friedhelm
T1  - Ökologisch verträgliche Dichtstoffe gegen drückendes Wasser
JF  - Bauchemie von der Forschung bis zur Praxis : (Beiträge der 1. Tagung Bauchemie in München) ; 21./22. November 1997 in München / GDCh-Fachgruppe Bauchemie ; [GDCh, Gesellschaft Deutscher Chemiker]
Y1  - 1998
SN  - 3-924763-69-0
N1  - GDCh-Monographien 11,  Tagung Bauchemie <1, 1997, München>
SP  - 44
PB  - GDCh
CY  - Frankfurt am Main
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Haulena, Friedhelm
A1  - Stuckenbruck, U.
T1  - Ökologisch verträgliche Dichtstoffe
JF  - Umwelt. 25 (1995), H. 10
Y1  - 1995
SN  - 0041-6355
SP  - 430
EP  - 441
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Grupe, M.
T1  - Ökoaudit - ein neues Arbeitsfeld, auch für die Bodenkunde / Grupe, M. ; Lassonczyk, B.
JF  - Festschrift für Horst Wiechmann  / Pfeiffer, Eva-Maria [Hrsg.]
Y1  - 1995
N1  - Hamburger bodenkundliche Arbeiten ; 30
SP  - 63
EP  - 71
PB  - Verein zur Förderung der Bodenkunde
CY  - Hamburg
ER  - 
TY  - JOUR
A1  - Berndt, Heinz
A1  - Klostermeyer, Henning
A1  - Zahn, Helmut
T1  - Zur Synthese monomerer cyclischer Cystinpeptidderivate, I : Synthese der Sequenz A 6–9 des Schafinsulins als Cyclocystinylderivat
JF  - Justus Liebigs Annalen der Chemie
N2  - Es wird die Synthese der Sequenz A 6–9 des Schafinsulins in der geschützten Form Boc-Cys-Cys-Ala-Gly-OBuᵗ (5) sowie das Verhalten dieses monomeren cyclischen Cystinpeptidderivates gegenüber den in der Peptidchemie gebräuchlichen Reagenzien Bortrifluorid/Eisessig, Triäthylamin und Hydrazinhydrat beschrieben.
Y1  - 1972
U6  - http://dx.doi.org/10.1002/jlac.19727590109
SN  - 1099-0690
VL  - 759
IS  - 1
SP  - 114
EP  - 120
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wilhelm, Wolff
A1  - Berndt, Heinz
A1  - Brandenburg, Dietrich
T1  - Zur Synthese der Hühnerinsulin-A-Kette, I : Darstellung der Fragmente A1–8, A9–15, A1–7 und A8–15
JF  - Hoppe-Seyler's Zeitschrift für physiologische Chemie
Y1  - 1979
U6  - http://dx.doi.org/10.1515/bchm2.1979.360.2.1559
SN  - 1437-4315
SN  - 0018-4888
VL  - 360
IS  - 2
SP  - 1559
EP  - 1568
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Becker, Dieter
A1  - Riekert, Lothar
T1  - Zur Selektivität der partiellen Oxidation von Propen an Schalenkatalysatoren / Dieter Becker ; Michael Kotter ; Lothar Riekert
JF  - Chemie - Ingenieur - Technik. 61 (1989), H. 9
Y1  - 1989
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 748
EP  - 749
ER  - 
TY  - JOUR
A1  - Schnabel, Eugen
A1  - Schnabel, Henning
A1  - Berndt, Heinz
T1  - Zur selektiven acidolytischen Abspaltbarkeit der tert.-Butyloxycarbonyl-Gruppe
JF  - Justus Liebigs Annalen der Chemie
N2  - Die tert.-Butyloxycarbonyl-Gruppe (Boc) läßt sich mittels reiner Trifluoressigsäure nicht selektiv neben dem Benzyloxycarbonyl-Rest (Z) abspalten. Das gelingt auch nicht mit Lösungen von Trifluoressigsäure bzw. Chlorwasserstoff in organischen Lösungsmitteln. Kern-substituierte Z-Gruppen wie Z(pCl), Z(mCl) oder Z(pNO₂) sind zwar stabiler, werden aber von den obengenannten Reagenzien ebenfalls angegriffen bzw. sind nicht mehr acidolytisch abspaltbar. – Mit 70proz. wäßriger Trifluoressigsäure gelingt die Abspaltung von Boc neben Z dagegen fast selektiv; dabei werden aber Benzylester, besonders Glutaminsäure-γ-benzylester, teilweise hydrolysiert, während Methyl- sowie Äthylester nahezu beständig sind. Die Brauchbarkeit des Abspaltungsverfahrens wird anhand der schrittweise durchgeführten Synthese zweier Heptapeptid-Derivate gezeigt. – Ähnlich spezifisch gelingt die Abspaltung von Boc mit Bortrifluorid-ätherat in Eisessig; Benzylester sind gegenüber diesem Reagenz stabiler als gegen wäßrige Trifluoressigsäure. Das Bortrifluorid-Verfahren eignet sich besonders für die Abspaltung von Boc-Gruppen neben säurelabilen Thiol-Schutzgruppen (Tetrahydropyranyl- bzw. Trityl-Rest) sowie neben dem Cyclocystinyl-Rest. Die Leistungsfähigkeit der Methode wird durch die Synthese zweier Peptid-Derivate mit S-Trityl-Schutzgruppen belegt. Als Nebenreaktion ist die Acetylierung von aliphatischen Hydroxylgruppen möglich. Sie läßt sich vermeiden, wenn man die Spaltung in anderen Lösungsmitteln durchführt. Die als Modellverbindungen für Stabilitätsuntersuchungen verwendeten Nε-acylierten Lysin-Derivate werden mit dem Aminosäureanalysator quantitativ neben Lysin bestimmt.
Y1  - 1971
U6  - http://dx.doi.org/10.1002/jlac.19717490111
SN  - 1099-0690
VL  - 749
IS  - 1
SP  - 90
EP  - 108
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Berndt, Heinz
T1  - Zur Reaktion von Iminodithiocarbonaten mit Carbonsäuren. I : Synthese des Modellpeptid-Derivates Z-(L)-Ala-(L/D)-Phe-(L)-Val-OMe
JF  - Tetrahedron letters
Y1  - 1980
U6  - http://dx.doi.org/10.1016/S0040-4039(00)78663-1
SN  - 0040-4039
VL  - 21
IS  - 34
SP  - 3265
EP  - 3268
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
T1  - Zur Radiopharmazie kardialer und kardiovaskulärer Radiopharmazeutika
JF  - Kardiologische Nuklearmedizin / G. Hör [Hrsg.]
Y1  - 1997
SN  - 3-609-62970-3
SP  - 27
EP  - 42
PB  - ecomed
CY  - Landsberg
ER  - 
TY  - JOUR
A1  - Mootz, D.
A1  - Merschenz-Quack, Angelika
T1  - Zur Kenntnis der höchsten Hydrate der Schwefelsäure: Bildung und Struktur von H2SO4·6,5 H2O und H2SO4·8H2O
JF  - Zeitschrift für Naturforschung B: Journal of chemical sciences
Y1  - 1987
SN  - 1865-7117 (E-Journal); 0932-0776 (Print)
VL  - 42
IS  - H. 10
SP  - 1231
EP  - 1236
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Xenobiotic receptor humanized mice and their utility
JF  - Drug Metabolism Reviews
Y1  - 2013
U6  - http://dx.doi.org/10.3109/03602532.2012.738687
SN  - 1097-9883
IS  - 1
SP  - 110
EP  - 121
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Wässrige Kunststoffdispersionen für Medizin und Biotechnologie
JF  - Chemie und Technologie makromolekularer Stoffe. 15. Kolloquium: 25. November 1994 an der FH Aachen, Fachbereich Chemieingenieurwesen
Y1  - 1994
N1  - FH-Texte 66. Fachhochschule <Aachen>
SP  - 155
EP  - 183
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Noll, T.
A1  - Wandrey, C.
T1  - Wirbelschichtreaktor und Biomasse-Monitor : ein leistungsfähiges Fermenationssystem für Säugerzellen / Noll, T. ; Biselli, M. ; Wandrey, C.
JF  - Biospektrum. 2 (1996), H. 1
Y1  - 1996
SN  - 0947-0867
SP  - 65
EP  - 67
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Wiederverwertung von Kunststoff-Verbundmaterial
JF  - Chemie und Technologie makromolekularer Stoffe. 16. Kolloquium: 20. November 1998 an der FH Aachen, Fachbereich Chemieingenieurwesen
Y1  - 1998
N1  - FH-Texte 69. Fachhochschule <Aachen>
SP  - 191
EP  - 213
PB  - Fachhochschule Aachen
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Haulena, Friedhelm
A1  - Rose, Gerd
T1  - Werkstoffliche Wiederverwertung von Arzneimittelblistern
JF  - Kunststoffrecycling in Sachsen.  4
Y1  - 1995
SP  - 119
EP  - 137
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Haulena, Friedhelm
A1  - Mathews, W.
A1  - Neuroth, N.
T1  - Verwertung gebrauchter Teppichböden / Haulena, Friedhelm ; Mang, Thomas ; Mathews, W. ; Neuroth, N.
JF  - Umwelt. 26 (1996), H. 7/8
Y1  - 1996
SN  - 0041-6355
SP  - 50
EP  - 53
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Häfele, E.
A1  - Prinz, D.
A1  - Riekert, L.
T1  - Versuche zur Konvertierung von Wassergas an Zeolith-Katalysatoren / E. Häfele ; M. Kotter ; D. Prinz ; L. Riekert
JF  - Chemie - Ingenieur - Technik. 55 (1983), H. 2
Y1  - 1983
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 148
EP  - 149
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Haulena, Friedhelm
T1  - Veranstaltung des 15. Kolloquiums Chemie und Technologie makromolekularer Stoffe: wässrige Kunststoffdispersionen, FH Aachen (1994)
JF  - Farbe und Lack. 101 (1995), H. 1
Y1  - 1995
SN  - 0014-7699
SP  - 72
EP  - 72
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Campos-Ortega, José A.
T1  - Use of the Gal4-UAS technique for targeted gene expression in the zebrafish
JF  - Mechanism of Development
Y1  - 1999
U6  - http://dx.doi.org/10.1016/S0925-4773(98)00209-3
SN  - 0925-4773
VL  - 80
IS  - 2
SP  - 153
EP  - 158
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Baltensperger, Urs
A1  - Ammann, Markus
A1  - Bochert, Ulrich K.
T1  - Use of 13N for Studies of the Selective Reduction of NO by NH3 over Vanadia/Titania Catalyst at Very Low Reactant Concentrations / Urs Baltensperger, Markus Ammann, Ulrich K. Bochert, Bernd Eichler, Heinz W. Gäggeler, Dieter T. Jost, Joseph A. Kovacs,  An
JF  - Journal of Physical Chemistry. 97 (1993)
Y1  - 1993
SN  - 0022-3654
SP  - 12325
EP  - 12330
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Wiechmann, H.
T1  - Untersuchungen zur Verlagerung und Immobilisierung löslicher organischer Stoffe in Sandböden
JF  - Mitteilungen der Deutschen Bodenkundlichen Gesellschaft. 43 (1985)
Y1  - 1985
SN  - 0343-107x
SP  - 771
EP  - 776
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Ma, J.
A1  - Hoffmann, U.
T1  - Untersuchungen zur Rußfilterregeneration mit Hilfe von Zündhilfen. Ma, J.; Hoffmann, U.; Feuerriegel, U
JF  - Erdöl und Kohle – Erdgas, Brennstoff-Chemie. 43 (1990)
Y1  - 1990
SN  - 0014-0058
N1  - Druckausgabe in Jülich unter 63 ZS 034-1990 vorhanden
SP  - 150
EP  - 157
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Klose, W.
T1  - Untersuchungen zum Mechanismus der Desaktivierung eines Palladium-Trägerkatalysators durch Vergiftung mit Schwefelwasserstoff
JF  - Chemie - Ingenieur - Technik. 70 (1998), H. 4
Y1  - 1998
SN  - 0009-286X
N1  - Artikel in Englisch unter <a href="http://www3.interscience.wiley.com/cgi-bin/fulltext/40001930/PDFSTART">Chemical engineering & technology. 21(1998)7. S. 562-564</a>
SP  - 449
EP  - 452
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Wiechmann, H.
T1  - Untersuchungen zum Akkumulationsverhalten löslicher organischer Substanzen in Podsolen
JF  - Mitteilungen der Deutschen Bodenkundlichen Gesellschaft. 55 (1987)
Y1  - 1987
SN  - 0343-107x
SP  - 791
EP  - 796
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Stahlberg, R.
T1  - Untersuchungen an der Thermoselect-Anlage Fondotoce (Italien), Qualitäten der Produkte und Nachweis der Verteilung der chemischen Elemente in den Stoffströmen. Stahlberg, R.; Feuerriegel, U.
JF  - Thermoselect : der neue Weg, Restmüll umweltgerecht zu behandeln ; [Tagungsband zur Fachtagung Thermoselect am 19. Januar 1995 in Rastatt/Baden] / Günther Häßler. 2. durchges. und erw. Aufl.
Y1  - 1995
SN  - 3-9803665-4-5
N1  - Fachtagung THERMOSELECT ; (1995, Rastatt) ; Fachtagung Thermoselect ; (1995.01.19 : ; Rastatt)
SP  - 33
EP  - 54
PB  - Goerner
CY  - Karlsruhe
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
T1  - Untersuchung einer Chronosequenz in Nord-Somalia zur Kennzeichnung der Landschaftsgeschichte
JF  - 14th International Congress of Soil Science : transactions. vol. 5. Kyoto, Japan, August 12 - 18, 1990 = 14ème Congrès International de la Science du Sol = 14. Internationaler Bodenkundlicher Kongreß / International Society of Soil Science
Y1  - 1990
N1  - International Congress of Soil Science ; <14 : ; 1990.08.12-18 : ; Kyoto>
SP  - 370
EP  - 371
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Lintz, Hans-Günther
A1  - Wittstock, Klaus
T1  - Untersuchung der Zwischenproduktbildung bei der katalytischen Nachverbrennung Iösemittelbeladener Abluft an Nichtedelmetall-Katalysatoren
JF  - Chemie - Ingenieur - Technik. 66 (1994), H. 10
Y1  - 1994
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 1369
EP  - 1372
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Grupe, M.
T1  - Umweltaudit aus der Sicht des Bodenschutzes
JF  - Umweltschutz-Management und Öko-Auditing / Manfred Sietz ... (Hrsg.)
Y1  - 1993
SN  - 3-540-56911-1
SP  - 133
EP  - 141
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Jacobi, M.
A1  - Castillo, J.
A1  - Foerstel, D. H.
T1  - Ultra-low-level measurements of 3H and 14C in wines and champagne / Scherer, U. W. ; Jacobi, M. ; Castillo, J. ; Foerstel, D. H.
JF  - Radiation effects and defects in solids. 164 (2009), H. 5-6
Y1  - 2009
SN  - 1042-0150
SP  - 382
EP  - 385
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Hermann, Gloria
A1  - Jessen, Holly
A1  - Gokarn, Ravi R.
T1  - Two beta-alanyl-CoA:ammonia lyases in Clostridium propionicum / Herrmann , G. ;  Selmer,  T. ; Jessen,  HJ. ; Gokarn,  RR. ; Selifonova,  O. ;  Gort , SJ. ; , Buckel, W.
JF  - The FEBS Journal. 272 (2005), H. 3
Y1  - 2005
SN  - 1742-464X
SP  - 813
EP  - 821
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, L.
T1  - Tränkkontakte zur partiellen Oxidation von Buten zu Maleinsäureanhydrid
JF  - Chemie - Ingenieur - Technik. 59 (1987), H. 9
Y1  - 1987
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 733
EP  - 734
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Ngyugen, Hung Huy
A1  - Kahlcke, Nils
A1  - Deflon, Victor M.
A1  - Abram, Ulrich
T1  - Tricarbonyltechnetium(I) and -rhenium(I) complexes with N′-thiocarbamoylpicolylbenzamidines
JF  - Polyhedron
N2  - N,N-Dialkylamino(thiocarbonyl)-N′-picolylbenzamidines react with (NEt4)2[M(CO)3X3] (M = Re, X = Br; M = Tc, X = Cl) under formation of neutral [M(CO)3L] complexes in high yields. The monoanionic NNS ligands bind in a facial coordination mode and can readily be modified at the (CS)NR1R2 moiety. The complexes [99Tc(CO)3(LPyMor)] and [Re(CO)3(L)] (L = LPyMor, LPyEt) were characterized by X-ray diffraction. Reactions of [99mTc(CO)3(H2O)3]+ with the N′-thiocarbamoylpicolylbenzamidines give the corresponding 99mTc complexes. The ester group in HLPyCOOEt allows linkage between biomolecules and the metal core.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.poly.2012.04.008
SN  - 0277-5387
VL  - 40
IS  - 1
SP  - 153
EP  - 158
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Barbazán, Paula
A1  - Hagenbach, Adelheid
A1  - Paulßen, Elisabeth
A1  - Abram, Ulrich
A1  - Carballo, Rosa
A1  - Rodriguez-Hermida, Sabina
A1  - Vázquez-López, Ezequiel M.
T1  - Tricarbonyl Rhenium(I) and Technetium(I) Complexes with Hydrazones Derived from 4,5-Diazafluoren-9-one and 1,10-Phenanthroline-5,6-dione
JF  - European Journal of Inorganic Chemistry
N2  - Tricarbonylrhenium(I) and -technetium(I) halide (halide = Cl and Br) complexes of ligands derived from 4,5-diazafluoren-9-one (df) and 1,10-phenanthroline-5,6-dione (phen) derivatives of benzoic and 2-hydroxybenzoic acid hydrazides have been prepared. The complexes have been characterized by elemental analysis, MS, IR, 1H NMR and absorption and emission UV/Vis spectroscopic methods. The metal centres (ReI and TcI) are coordinated through the nitrogen imine atoms and establish five-membered chelate rings, whereas the hydrazone groups stand uncoordinated. The 1H NMR spectra suggest the same behaviour in solution on the basis of only marginal variations in the chemical shifts of the hydrazine protons.
Y1  - 2010
U6  - http://dx.doi.org/10.1002/ejic.201000522
SN  - 1099-0682
IS  - 29
SP  - 4622
EP  - 4630
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Haulena, Friedhelm
A1  - Rose, Gerd
T1  - Trennung und werkstoffliche Verwertung von Aluminium-Kunststoff-Verbundmaterial
JF  - Aluminium. 70 (1994), H. 5/6
Y1  - 1994
SN  - 0002-6689
SP  - 333
EP  - 339
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
T1  - Trennen und Trocknen. FH Aachen verfügt über einen Zentrifugentrockner im Technikumsmaßstab
JF  - Lebensmitteltechnik. 33 (2001), H. 7-8
Y1  - 2001
SN  - 0047-4290
SP  - 22
EP  - 23
ER  - 
TY  - JOUR
A1  - Bongaerts, Johannes
A1  - Zoschke, Sascha
A1  - Weidner, Uwe
A1  - Linden, Gottfried
T1  - Transcriptional regulation of the proton translocating NADH
JF  - Molecular microbiology
Y1  - 1995
SN  - 1365-2958 (E-Journal); 0950-382x (Print)
VL  - Vol. 16
IS  - Iss. 3
SP  - 521
EP  - 534
ER  - 
TY  - JOUR
A1  - Halbach, Thorsten
A1  - Scheer, Nico
T1  - Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins
JF  - Nucleic Acids Research
Y1  - 2000
U6  - http://dx.doi.org/10.1093/nar/28.18.3542
SN  - 1362-4962
VL  - 28
IS  - 18
SP  - 3542
EP  - 3550
ER  - 
TY  - JOUR
A1  - Bode, J.
A1  - Bartsch, J.
A1  - Boulikas, T.
A1  - Iber, M.
A1  - Mielke, C.
A1  - Schübeler, D.
A1  - Seibler, Jost
A1  - Benham, C.
T1  - Transcription-promoting genomic sites in mammalia: their elucidation and architectural principles
JF  - Gene therapy & molecular biology
Y1  - 1998
SN  - 1529-9120
VL  - 1
IS  - 1
SP  - 1
EP  - 29
ER  - 
TY  - JOUR
A1  - Becht, Alexander
A1  - Schollmayer, Curd
A1  - Monakhova, Yulia
A1  - Holzgrabe, Ulrike
T1  - Tracing the origin of paracetamol tablets by near-infrared, mid-infrared, and nuclear magnetic resonance spectroscopy using principal component analysis and linear discriminant analysis
JF  - Analytical and Bioanalytical Chemistry
N2  - Most drugs are no longer produced in their own countries by the pharmaceutical companies, but by contract manufacturers or at manufacturing sites in countries that can produce more cheaply. This not only makes it difficult to trace them back but also leaves room for criminal organizations to fake them unnoticed. For these reasons, it is becoming increasingly difficult to determine the exact origin of drugs. The goal of this work was to investigate how exactly this is possible by using different spectroscopic methods like nuclear magnetic resonance and near- and mid-infrared spectroscopy in combination with multivariate data analysis. As an example, 56 out of 64 different paracetamol preparations, collected from 19 countries around the world, were chosen to investigate whether it is possible to determine the pharmaceutical company, manufacturing site, or country of origin. By means of suitable pre-processing of the spectra and the different information contained in each method, principal component analysis was able to evaluate manufacturing relationships between individual companies and to differentiate between production sites or formulations. Linear discriminant analysis showed different results depending on the spectral method and purpose. For all spectroscopic methods, it was found that the classification of the preparations to their manufacturer achieves better results than the classification to their pharmaceutical company. The best results were obtained with nuclear magnetic resonance and near-infrared data, with 94.6%/99.6% and 98.7/100% of the spectra of the preparations correctly assigned to their pharmaceutical company or manufacturer.
KW  - IR
KW  - Manufacturer
KW  - Linear discriminant analysis
KW  - Principal component analysis
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s00216-021-03249-z
SN  - 1618-2650
VL  - 413
SP  - 3107
EP  - 3118
PB  - Springer Nature
ER  - 
TY  - JOUR
A1  - Raab, Monika
A1  - Kappel, Sven
A1  - Krämer, Andrea
A1  - Sanhaji, Mourad
A1  - Matthess, Yves
A1  - Kurunci-Csacsko, Elisabeth
A1  - Calzada-Wack, Julia
A1  - Rathkolb, Birgit
A1  - Rosman, Jan
A1  - Adler, Thure
A1  - Busch, Dirk H.
A1  - Esposito, Irene
A1  - Fuchs, Helmut
A1  - Gailus-Durner, Valérie
A1  - Klingenspor, Martin
A1  - Wolf, Eckhard
A1  - Sänger, Nicole
A1  - Prinz, Florian
A1  - Hrabe de Angelis, Martin
A1  - Seibler, Jost
A1  - Yuan, Juping
A1  - Bergmann, Martin
A1  - Knecht, Rainald
A1  - Kreft, Bertolt
A1  - Strebhardt, Klaus
T1  - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
JF  - Nature Communications
Y1  - 2011
U6  - http://dx.doi.org/10.1038/ncomms1395
SN  - 2041-1723
VL  - 2
IS  - 395
SP  - 1
EP  - 11
PB  - Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Welden, Melanie
A1  - Poghossian, Arshak
A1  - Vahidpour, Farnoosh
A1  - Wendlandt, Tim
A1  - Keusgen, Michael
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers
JF  - Biosensors
N2  - Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1–3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.
KW  - urease
KW  - enzyme-logic gate
KW  - bi-enzyme biosensor
KW  - capacitive field-effect sensor
KW  - tobacco mosaic virus (TMV)
KW  - penicillinase
Y1  - 2022
U6  - http://dx.doi.org/10.3390/bios12010043
SN  - 2079-6374
N1  - This article belongs to the Special Issue "Biosensors: 10th Anniversary Feature Papers"
VL  - 12
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Sorich, Maren
A1  - Bartz, Alexander
A1  - Siegert, Petra
A1  - Willenberg, Holger S.
A1  - Lisdat, Fred
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate
JF  - Sensors and Actuators B: Chemical
N2  - An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer’s solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.snb.2016.06.064
SN  - 0925-4005
VL  - 237
SP  - 190
EP  - 195
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Takenaga, Shoko
A1  - Biselli, Manfred
A1  - Schnitzler, Thomas
A1  - Öhlschläger, Peter
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis–Menten-like kinetics for cell culturing
JF  - Physica status solidi A : Applications and materials science
N2  - The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17–200 mM) follows a Michaelis–Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201330464
SN  - 1521-396X (E); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1410
EP  - 1415
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Röhlen, Desiree
A1  - Pilas, Johanna
A1  - Dahmen, Markus
A1  - Keusgen, Michael
A1  - Selmer, Thorsten
A1  - Schöning, Michael Josef
T1  - Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes
JF  - Frontiers in Chemistry
N2  - Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes.
Y1  - 2018
U6  - http://dx.doi.org/10.3389/fchem.2018.00284
IS  - 6
PB  - Frontiers
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Immel, Timo A.
A1  - Groth, Ulrich
A1  - Huhn, Thomas
A1  - Öhlschläger, Peter
T1  - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice
JF  - PLoS ONE
N2  - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
Y1  - 2011
U6  - http://dx.doi.org/10.1371/journal.pone.0017869
VL  - 6
IS  - 3
PB  - Plos
CY  - San Francisco, California, US
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Thermosensitive Magnetic Nanoparticles for Bioanalytical and Therapeutical Applications
JF  - Biomedizinische Technik = Biomedical Engineering. 49 (2004), H. 2
Y1  - 2004
SN  - 0013-5585
SP  - 1006
EP  - 1007
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Stahlberg, R.
A1  - Riegel, J.
A1  - Steiger, F.
T1  - Thermoselect – Energie- und Rohstoffgewinnung: Teil 3. Massen- und Energiebilanz unter Berücksichtigung der Wirtschaftlichkeit der Synthesegasnutzung. Stahlberg, R.; Riegel, J.; Feuerriegel, U.; Steiger, F.
JF  - Chemische Technik <Leipzig>. 47 (1995), H. 3
Y1  - 1995
SN  - 0045-6519
SP  - 113
EP  - 121
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Stahlberg, R.
T1  - Thermoselect – Energie- und Rohstoffgewinnung: Teil 2. Untersuchungen an der Thermoselect-Anlage Fondotoce (Italien), Qualitäten der Produkte und Nachweis der Verteilung der chemischen Elemente in den Stoffströmen. Stahlberg, R. ; Feuerriegel, U.
JF  - Chemische Technik <Leipzig>. 47 (1995), H. 1
Y1  - 1995
SN  - 0045-6519
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Stahlberg, R.
T1  - Thermoselect – Energie- und Rohstoffgewinnung: Teil 1. Verfahrensgrundlagen zur unterbrechungslosen Verwertung von Restabfällen. Stahlberg, R. ; Feuerriegel, U.
JF  - Chemische Technik <Leipzig>. 46 (1994), H. 5
Y1  - 1994
SN  - 0045-6519
SP  - 257
EP  - 266
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Stahlberg, R.
T1  - Thermoselect – Energie- und Rohstoffgewinnung. Stahlberg, R. ; Feuerriegel, U.
JF  - Abfallwirtschaft Stoffkreisläufe / Terratec '95, Kongress West-Ost-Transfer Umwelt vom 1. bis 3. März 1995. Leipziger Messe. Hrsg. von Hasso Scheffler ...
Y1  - 1995
SN  - 3-8154-3513-7
N1  - Terratec <1995, Leipzig> ; Kongress West-Ost-Transfer Umwelt <1995, Leipzig> ; Leipziger Messe
SP  - 179
EP  - 194
PB  - Teubner
CY  - Stuttgart [u.a.]
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Stahlberg, R.
T1  - Thermoselect – Energie- und Rohstoffgewinnung, Verfahrensgrundlagen zur unterbrechungslosen Verwertung von Restabfällen. Stahlberg, R.; Feuerriegel, U.
JF  - Thermoselect : der neue Weg, Restmüll umweltgerecht zu behandeln ; [Tagungsband zur Fachtagung Thermoselect am 19. Januar 1995 in Rastatt/Baden] / Günther Häßler. 2. durchges. und erw. Aufl.
Y1  - 1995
SN  - 3-9803665-4-5
N1  - Fachtagung THERMOSELECT ; (1995, Rastatt) ; Fachtagung Thermoselect ; (1995.01.19 : ; Rastatt)
SP  - 13
EP  - 32
PB  - Goerner
CY  - Karlsruhe
ER  - 
TY  - JOUR
A1  - Matoni, Georg
A1  - Berndt, Heinz
T1  - Thermal synthesis of the optical pure pentapeptide derivative Z-(L)-Ala-(L)-Phe-Gly-(L)-Phe-Gly-OMe
JF  - Tetrahedron letters
Y1  - 1980
U6  - http://dx.doi.org/10.1016/S0040-4039(00)93618-9
SN  - 0040-4039
VL  - 21
IS  - 1
SP  - 37
EP  - 40
ER  - 
TY  - JOUR
A1  - Guo, Yuanyuan
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Theoretical study and simulation of light-addressable potentiometric sensors
JF  - Physica status solidi (A) : applications and materials
N2  - The light-addressable potentiometric sensor (LAPS) is a semiconductor-based potentiometric sensor using a light probe with an ability of detecting the concentration of biochemical species in a spatially resolved manner. As an important biomedical sensor, research has been conducted to improve its performance, for instance, to realize high-speed measurement. In this work, the idea of facilitating the device-level simulation, instead of using an equivalent-circuit model, is presented for detailed analysis and optimization of the performance of the LAPS. Both carrier distribution and photocurrent response have been simulated to provide new insight into both amplitude-mode and phase-mode operations of the LAPS. Various device parameters can be examined to effectively design and optimize the LAPS structures and setups for enhanced performance.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201330354
SN  - 0031-8965
VL  - 211
IS  - 6
SP  - 1467
EP  - 1472
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bode, Jürgen
A1  - Schlake, Thomas
A1  - Iber, Michaela
A1  - Schübeler, Dirk
A1  - Seibler, Jost
A1  - Snezhkov, Evgeney
A1  - Nikolaev, Lev
T1  - The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes
JF  - Biological Chemistry
Y1  - 2000
U6  - http://dx.doi.org/10.1515/BC.2000.103
SN  - 1431-6730
VL  - 381
IS  - 9-10
SP  - 801
EP  - 813
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Lancelot, C.
A1  - Brandini, F.
A1  - Sakshaug, E.
T1  - The taxonomic identity of the cosmopolitan prymnesiophyte Phaeocystis, a morphological and ecophysiological approach / Baumann, M.E.M. ; Lancelot, C. ; Brandini, F. ; Sakshaug, E. ; John M.
JF  - Journal of Marine Systems. 5 (1994), H. 1
Y1  - 1994
SN  - 0924-7963
SP  - 5
EP  - 22
ER  - 
TY  - JOUR
A1  - Demmer, Julius K.
A1  - Chowdhury, Nilanjan Pal
A1  - Selmer, Thorsten
A1  - Ermler, Ulrich
A1  - Buckel, Wolfgang
T1  - The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
JF  - Nature Communications
Y1  - 2017
U6  - http://dx.doi.org/10.1038/s41467-017-01746-3
SN  - 2041-1723
N1  - Article number 1577
VL  - 8
IS  - 1
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Lengkeek, Nigel A.
A1  - Le, Van So
A1  - Pellegrini, Paul A.
A1  - Greguric, Ivan
A1  - Weiner, Ron
T1  - The role of additives in moderating the influence of Fe(III) and Cu(II) on the radiochemical yield of [⁶⁸Ga(DOTATATE)]
JF  - Applied Radiation and Isotopes
N2  - [⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.apradiso.2015.09.008
SN  - 1872-9800
VL  - 107
SP  - 13
EP  - 16
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Voigt, Birgit
A1  - Schroeter, Rebecca
A1  - Jürgen, Britta
A1  - Albrecht, Dirk
A1  - Evers, Stefan
A1  - Bongaerts, Johannes
A1  - Maurer, Karl-Heinz
A1  - Schweder, Thomas
A1  - Hecker, Michael
T1  - The response of Bacillus licheniformis to heat and ethanol stress and the role of the SigB regulon
JF  - Proteomics
Y1  - 2013
SN  - 1615-9861 (E-Journal); 1615-9853 (Print)
VL  - Vol. 13
IS  - Iss. 14
SP  - 2140
EP  - 2146
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Lang, E. W.
A1  - Speedy, R. J.
A1  - Lüdemann, H.-D.
T1  - The pressure Dependence of Self Diffusion in Supercooled Light and Heavy Water / F.X. Prielmeier, E .W. Lang, R. J. Speedy, H.-D. Lüdemann
JF  - Berichte der Bunsen-Gesellschaft für Physikalische Chemie. 92 (1988)
Y1  - 1988
SN  - 0005-9021
SP  - 1111
ER  - 
TY  - JOUR
A1  - Wilson, Ian D.
A1  - Wilson, Claire E.
A1  - Scheer, Nico
A1  - Dickie, A.P.
A1  - Schreiter, K.
A1  - Wilson, E. M.
A1  - Riley, R. J.
A1  - Wehr, R.
A1  - Bial, J.
T1  - The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
JF  - Biochemical pharmacology
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.bcp.2017.03.015
SN  - 1873-2968
VL  - Volume 135
SP  - 139
EP  - 150
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilson, C. E.
A1  - Dickie, A. P.
A1  - Schreiter, K.
A1  - Wehr, R.
A1  - Wilson, E. M.
A1  - Bial, J.
A1  - Scheer, Nico
A1  - Wilson, I. D.
A1  - Riley, R. J.
T1  - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
JF  - Archives of Toxicology
N2  - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
Y1  - 2018
U6  - http://dx.doi.org/10.1007/s00204-018-2212-1
SN  - 1432-0738
VL  - 92
IS  - 6
SP  - 1953
EP  - 1967
PB  - Springer
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, Lothar
A1  - Weyland, Friedrich
T1  - The performance of base metal oxides on ceramic carriers as catalysts for air pollution control
JF  - International chemical engineering. 25 (1985), H. 3
Y1  - 1985
SN  - 0020-6318
SP  - 418
EP  - 427
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Heßberger, F. P.
A1  - Gäggeler, H. W.
A1  - Armbruster, P.
T1  - The New Nuclide 225U / F.P. Heßberger, H. Gäggeler, P. Armbruster, W. Brüchle, H. Folger, S. Hofmann, D. Jost, J.V. Kratz, M.E. Leino, G. Münzenberg, V. Ninov, M. Schädel, U.W. Scherer, K. Sümmerer, A. Türler, D. Ackerman
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 333 (1989), H. 1
Y1  - 1989
SN  - 0939-7922
SP  - 111
EP  - 112
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Rousseau, V.
A1  - Vaulot, D.
A1  - Casotti, R.
T1  - The life cycle of Phaeocystis (Prymnesiophycae): evidence and hypotheses / Rousseau, V. ; Vaulot, D. ; Casotti, R. ; Cariou, V. ; Lenz, J. ; Gunkel, J. ; Baumann, M.
JF  - Journal of Marine Systems. 5 (1994), H. 1
Y1  - 1994
SN  - 0924-7963
SP  - 23
EP  - 39
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Goeyens, L.
A1  - Tréguer, P.
A1  - Baeyens, W.
T1  - The leading role of ammonium in the nitrogen uptake regime of Southern Ocean marginal ice zones / Goeyens, L. ; Tréguer, P. ; Baumann, M.E.M. ; Baeyens, W. ; Dehairs, F.
JF  - Journal of Marine Systems. 6 (1995), H. 4
Y1  - 1995
SN  - 0924-7963
SP  - 345
EP  - 361
ER  - 
TY  - JOUR
A1  - Lauth, Jakob
A1  - Solomun, T.
A1  - Hirschwald, W.
A1  - Christmann, K.
T1  - The interaction of carbon monoxide with a ruthenium(1010) surface
JF  - Surface Science. 210 (1989), H. 1-2
Y1  - 1989
SN  - 0039-6028
SP  - 201
EP  - 224
ER  - 
TY  - JOUR
A1  - Lauth, Jakob
A1  - Solomun, T.
A1  - Hirschwald, W.
A1  - Christmann, K.
T1  - The interaction of carbon monoxide with a ruthenium(1010) surface
JF  - Surface Science Letters. 210 (1989), H. 1-2
Y1  - 1989
SN  - 0167-2584
SP  - A74
EP  - A75
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Brandini, Frederico
A1  - Staubes, Regina
T1  - The influence of light and temperature on carbonspecific DMS release by cultures of Phaeocystis antarctica and three antarctic diatoms / Baumann, Marcus E.M. ; Brandini, Frederico ; Staubes, Regina
JF  - Marine Chemistry. 45 (1994), H. 1-2
Y1  - 1994
SN  - 0304-4203
SP  - 129
EP  - 136
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, L.
T1  - The influence of impregnation, drying and activation on the activity and distribution of CuO on &#945;-Alumina
JF  - Preparation of Catalysts II : scientific bases for the preparation of heterogeneous catalysts ; Proceedings of the Second International Symposium, Louvain-la-Neuve, September 4-7, 1978 / Eds.: B. Delmon ... - (Studies in surface science and catalysis ; 3)
Y1  - 1979
SN  - 0-444-41733-8
N1  - International Symposium on the Scientific Bases for the Preparation of Heterogeneous Catalysts <2, 1978, Louvain-la-Neuve>
SP  - 51
EP  - 63
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Thömmes, J.
A1  - Gätgens, J.
A1  - Runstadler, P. W.
T1  - The influence of dissolved oxygen tension on the metabolic activity of an immobilized hybridoma population / Thömmes, J. ; Gätgens, J. ; Biselli, M. ; Runstadler, P.W. ; Wandrey, C.
JF  - Cytotechnology . 13 (1993), H. 1
Y1  - 1993
SN  - 0920-9069
SP  - 29
EP  - 39
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Brüchle, W.
A1  - Schädel, M.
A1  - Kratz, J. V.
T1  - The Hydration Enthalpies of Md3+ and Lr3+ / W. Brüchle, M. Schädel, U.W. Scherer, J.V. Kratz, K.E. Gregorich, D. Lee, M. Nurmia, R.M. Chasteler, H.L. Hall, R.A. Henderson, D.C. Hoffman
JF  - Inorganica Chimica Acta. 146 (1988), H. 2
Y1  - 1988
SN  - 0020-1693
SP  - 267
EP  - 276
ER  - 
TY  - JOUR
A1  - Glaser, Stefan
A1  - Lubitz, Sandra
A1  - Loveland, Kate L.
A1  - Ohbo, Kazu
A1  - Robb, Lorraine
A1  - Schwenk, Frieder
A1  - Seibler, Jost
A1  - Roellig, Daniela
A1  - Kranz, Andrea
A1  - Anastassiadis, Konstantinos
A1  - Stewart, A. Francis
T1  - The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis
JF  - Epigenetics & Chromatin
Y1  - 2009
U6  - http://dx.doi.org/10.1186/1756-8935-2-5
SN  - 1756-8935
VL  - 2
IS  - 5
SP  - 1
EP  - 16
ER  - 
TY  - JOUR
A1  - Polen, T.
A1  - Krämer, Marco
A1  - Bongaerts, Johannes
A1  - Wubbolts, Marcel
A1  - Wendisch, V. F.
T1  - The global gene expression response of Escherichia coli to L-phenylalanine
JF  - Journal of biotechnology
Y1  - 2005
SN  - 1873-4863 (E-Journal); 0168-1656 (Print)
VL  - Vol. 115
IS  - Iss. 3
SP  - 221
EP  - 237
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Hallmann, Armin
A1  - Schmidt, Bernhard
A1  - Sumper, Manfred
T1  - The Evolutionary Conservation of a Novel Protein Modification, the Conversion of Cysteine to Serinesemialdehyde in Arylsulfatase from Volvox carteri / Selmer, Thorsten ; Hallmann, Armin ; Schmidt, Bernhard ; Sumper, Manfred ; Figura, Kurt von
JF  - European Journal of Biochemistry. 238 (1996), H. 2
Y1  - 1996
SN  - 0014-2956
SP  - 341
EP  - 345
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Spies, Elmar
A1  - Alvarez, Gerardo
A1  - Quetting, Michael
A1  - Groettrup, Marcus
T1  - The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA
JF  - International Journal of Cancer. 128 (2011), H. 2
Y1  - 2011
SN  - 1097-0215
SP  - 473
EP  - 481
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Kahnt, Jörg
A1  - Goubeaud, Marcel
A1  - Shima, Seigo
T1  - The biosynthesis of methylated amino acids in the active site region of methyl-coenzyme M reductase / Selmer, Thorsten ; Kahnt, Jörg ; Goubeaud, Marcel ; Shima, Seigo ; Grabarse, Wolfgang ; Ermler, Ulrich ; Thauer, Rudolf K.
JF  - Journal of Biological Chemistry. 275 (2000), H. 6
Y1  - 2000
SN  - 1083-351X
SP  - 3775
EP  - 3760
ER  - 
TY  - JOUR
A1  - Moret, J.L.T.M.
A1  - Alkemade, J.
A1  - Upcraft, T.M.
A1  - Paulßen, Elisabeth
A1  - Wolterbeek, H.T.
A1  - Ommen, J.R. van
A1  - Denkova, A.G.
T1  - The application of atomic layer deposition in the production of sorbents for ⁹⁹Mo/⁹⁹ᵐTc generator
JF  - Applied Radiation and Isotopes
N2  - New production routes for ⁹⁹Mo are steadily gaining importance. However, the obtained specific activity is much lower than currently produced by the fission of U-235. To be able to supply hospitals with ⁹⁹Mo/⁹⁹ᵐTc generators with the desired activity, the adsorption capacity of the column material should be increased. In this paper we have investigated whether the gas phase coating technique Atomic Layer Deposition (ALD), which can deposit ultra-thin layers on high surface area materials, can be used to attain materials with high adsorption capacity for ⁹⁹Mo. For this purpose, ALD was applied on a silica-core sorbent material to coat it with a thin layer of alumina. This sorbent material shows to have a maximum adsorption capacity of 120 mg/g and has a ⁹⁹ᵐTc elution efficiency of 55 ± 2% based on 3 executive elutions.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.apradiso.2020.109266
SN  - 0969-8043
VL  - 164
IS  - 109266
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
T1  - Tetrabenzo[a,c,h,j]phenoxazine-18-yl a new stable neutral radical
JF  - Tetrahedron Letters  . 42 (2001), H. 10
Y1  - 2001
SN  - 0040-4039
N1  - ISSN der E-Ausg.: 1359-8562
SP  - 1863
EP  - 1865
ER  - 
TY  - JOUR
A1  - Delaittre, Guillaume
T1  - Telechelic Poly(2-Oxazoline)s
JF  - European Polymer Journal
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.eurpolymj.2019.109281
SN  - 0014-3057
IS  - In Press, Journal Pre-proof, 109281
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Michel, Nico
A1  - Osen, Wolfram
A1  - Freyschmidt, Eva-Jasmin
T1  - T cell response to human papillomavirus 16 E7 in mice: comparison of Cr release assay, intracellular IFN-gamma production, ELISPOT and tetramer staining / Michel, Nico ; Öhlschläger, Peter ; Osen, Wolfram ; Freyschmidt, Eva-Jasmin ; Gutöhrlein, Heidrun ;
JF  - Intervirology. 45 (2002)
Y1  - 2002
SN  - 1423-0100
SP  - 290
EP  - 299
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Alberto, Roger
A1  - Abram, Ulrich
T1  - Synthesis, Characterization, and Structures of R3EOTcO3 Complexes (E = C, Si, Ge, Sn, Pb) and Related Compounds
JF  - Inorganic Chemistry
N2  - AgTcO4 reacts with R3ECl compounds (E = C, Si, Ge, Sn, Pb; R = Me, iPr, tBu, Ph), tBu2SnCl2, or PhMgCl under formation of novel trioxotechnetium(VII) derivatives. The carbon and silicon derivatives readily undergo decomposition, which was proven by 99Tc NMR spectroscopy and the isolation of decomposition products such as [TcOCl3(THF)(OH2)]. Compounds [Ph3GeOTcO3], [(THF)Ph3SnOTcO3], [(O3TcO)SntBu2(OH)]2, and [(THF)4Mg(OTcO3)2] are more stable and were isolated in crystalline form and characterized by X-ray diffraction.
Y1  - 2010
U6  - http://dx.doi.org/10.1021/ic1001094
SN  - 1520-510X
VL  - 49
IS  - 7
SP  - 3525
EP  - 3530
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Muschallik, Lukas
A1  - Kipp, Carina Ronja
A1  - Recker, Inga
A1  - Bongaerts, Johannes
A1  - Pohl, Martina
A1  - Gelissen, Melanie
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
A1  - Siegert, Petra
T1  - Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase
JF  - Journal of Biotechnology
N2  - The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled.
Y1  - 2020
SN  - 2590-1559
U6  - http://dx.doi.org/10.1016/j.jbiotec.2020.09.016
VL  - 202
IS  - Vol. 324
SP  - 61
EP  - 70
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Muschallik, Lukas
A1  - Molinnus, Denise
A1  - Jablonski, Melanie
A1  - Kipp, Carina Ronja
A1  - Bongaerts, Johannes
A1  - Pohl, Martina
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
A1  - Siegert, Petra
T1  - Synthesis of α-hydroxy ketones and vicinal (R, R)-diols by Bacillus clausii DSM 8716ᵀ butanediol dehydrogenase
JF  - RSC Advances
N2  - α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716ᵀ (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn²⁺ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated.
Y1  - 2020
U6  - http://dx.doi.org/10.1039/D0RA02066D
SN  - 2046-2069
VL  - 10
SP  - 12206
EP  - 12216
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Heinze, Daniel
A1  - Mang, Thomas
A1  - Peter, Karin
A1  - Möller, Martin
A1  - Weichold, Oliver
T1  - Synthesis of low molecular weight poly(vinyl acetate) and its application as plasticizer
JF  - Journal of applied polymer science
N2  - Poly(vinyl acetate), PVAc, with a degree of polymerization Xn = 10 was prepared by chain-transfer radical polymerization using carbon tetrachloride and used as oligomeric plasticizer for commercial PVAc. However, the chlorinated chain ends cause a low thermal stability requiring mild Cl/H substitution. The product exhibits high thermal stability and excellent melt-compounding properties. Blends of oligomeric and commercial PVAc show single glass transition temperatures which decrease with higher oligomer content and exhibit small negative deviations from Fox' linear additivity rule. This indicates plasticization and miscibility being mainly due to entropic effects. Injection-moulded thick specimens show ductile behaviour at oligomer contents >10 wt %, while sheets with a thickness of 0.2–0.5 mm appear flexible already at 7.5 wt %. The oxygen permeability coefficients are an order of magnitude lower than those of low-density polyethylene. Due to the sum of their properties, the plasticized sheets present a promising alternative in the preparation of barrier materials.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/app.40226
SN  - 1097-4628 (E-Journal); 0021-8995 (Print)
VL  - 131
IS  - 9
SP  - Article No. 40226
PB  - Wiley
CY  - New York
ER  - 
TY  - JOUR
A1  - Nokihara, Kiyoshi
A1  - Berndt, Heinz
T1  - Synthesis of hapten–polypeptide conjugates as antigen models for the N-terminal region of the α-2-chain of rabbit skin collagen
JF  - Journal of the Royal Society of Chemistry: Perkin Transactions 1
N2  - Synthesis of derivatives of the peptide sequence L-pyroglutamyl-L-phenylalanyl-L-aspartyl-glycyl-L-lysyl-glycyl-glycyl-glycine as the antigenic determinant representing the N-terminal non-helical region of the α-2-chain of rabbit skin collagen, and conjugation to two different polypeptide carriers, are described.
Y1  - 1978
U6  - http://dx.doi.org/10.1039/P19780000260
SN  - 1364-5463
SN  - 0300-922X
SN  - 1470-4358
VL  - 1978
IS  - 3
SP  - 260
EP  - 263
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Immel, Timo
A1  - Grützke, Martin
A1  - Späte, Anne-Katrin
A1  - Groth, Ulrich
A1  - Öhlschläger, Peter
A1  - Huhn, Thomas
T1  - Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy
JF  - Chemical Communications
N2  - Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
Y1  - 2012
U6  - http://dx.doi.org/10.1039/C2CC31624B
SN  - 1364-548X
VL  - 48
IS  - 46
SP  - 5790
EP  - 5792
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Pellegrini, Paul A.
A1  - Howell, Nicholas R.
A1  - Shepherd, Rachael K.
A1  - Lengkeek, Nigel A.
A1  - Paulßen, Elisabeth
A1  - Katsifis, Andrew G.
A1  - Greguric, Ivan
T1  - Synthesis and Radiolabelling of DOTA-Linked Glutamine Analogues with 67,68Ga as Markers for Increased Glutamine Metabolism in Tumour Cells
JF  - Molecules
Y1  - 2013
U6  - http://dx.doi.org/10.3390/molecules18067160
SN  - 1420-3049
VL  - 18
IS  - 6
SP  - 7160
EP  - 7178
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Meyer-Stork, L. Sebastian
A1  - Höcker, Hartwig
A1  - Berndt, Heinz
T1  - Syntheses and reactions of urethanes of cellobiose and cellulose-containing uretdione groups
JF  - Journal of applied polymer science
Y1  - 1992
SN  - 1097-4628
VL  - 44
IS  - 6
SP  - 1043
EP  - 1049
ER  - 
TY  - JOUR
A1  - Wolf, Wilhelm
A1  - Berndt, Heinz
A1  - Brandenburg, Dietrich
T1  - Synthese von Fragmenten einer [LysA13] Rinder-Insulin-A-Kette unter Verwendung des S-tert-Butylmercaptorestes als Thiolschutz
JF  - Hoppe-Seyler's Zeitschrift für physiologische Chemie
Y1  - 1979
U6  - http://dx.doi.org/10.1515/bchm2.1979.360.2.1549
SN  - 1437-4315
SN  - 0018-4888
VL  - 360
IS  - 2
SP  - 1549
EP  - 1558
ER  - 
TY  - JOUR
A1  - Berndt, Heinz
T1  - Synthese der Sequenz 71—86 des Humanproinsulins, III : Synthese über die Fragmente 71—78 und 79—86
JF  - Hoppe-Seyler's Zeitschrift für physiologische Chemie
Y1  - 1979
U6  - http://dx.doi.org/10.1515/bchm2.1979.360.1.765
SN  - 1437-4315
SN  - 0018-4888
VL  - 360
IS  - 1
SP  - 765
EP  - 772
ER  - 
TY  - JOUR
A1  - Berndt, Heinz
T1  - Synthese der Sequenz 71—86 des Humanproinsulins, I : Synthese der Sequenz 71—86 als monomeres cyclisches Biscystinpeptidderivat und als Tetra-S-tritylderivat
JF  - Hoppe-Seyler's Zeitschrift für physiologische Chemie
Y1  - 1979
U6  - http://dx.doi.org/10.1515/bchm2.1979.360.1.747
SN  - 1437-4315
SN  - 0018-4888
VL  - 360
IS  - 1
SP  - 747
EP  - 760
ER  - 
TY  - JOUR
A1  - Gielen, Hans-Günther
A1  - Wolf, Günter
A1  - Berndt, Heinz
A1  - Zahn, Helmut
T1  - Synthese der Fragmente A1–8, A9–15 und A16–21 der Schafinsulin-A-Kette unter Verwendung des S-tert-Butylmercaptorestes als Thiolschutzgruppe
JF  - Hoppe-Seyler's Zeitschrift für physiologische Chemie
Y1  - 1979
U6  - http://dx.doi.org/10.1515/bchm2.1979.360.2.1535
SN  - 1437-4315
SN  - 0018-4888
VL  - 360
IS  - 2
SP  - 1535
EP  - 1548
ER  - 
TY  - JOUR
A1  - Wolf, Günter
A1  - Berndt, Heinz
A1  - Brandenburg, Dietrich
T1  - Synthese der [LysA13] Rinderinsulin-A-Kette in der Form [Lys(Tfa)A13]A(SO3H)4 und NαA1-Msc-[LysA13]A(SO3H)4 unter Verwendung des S-tert-Butylmercapto-Restes als Thiolschutzgruppe
JF  - Hoppe-Seyler's Zeitschrift für physiologische Chemie
Y1  - 1979
U6  - http://dx.doi.org/10.1515/bchm2.1979.360.2.1569
SN  - 1437-4315
SN  - 0018-4888
VL  - 360
IS  - 2
SP  - 1569
EP  - 1578
ER  - 
TY  - JOUR
A1  - Turck, Christoph W.
A1  - Berndt, Heinz
T1  - Synthese definierter Peptid-Derivate durch Aminolyse von 3-(Nα-Acyl-peptidyloxy)-2-hydroxy-N-alkylbenzamiden bei erhöhten Temperaturen, I : Synthese des Modellpeptid-Derivates Z-Ala-Phe-Gly-N(Et)2
JF  - Hoppe-Seyler´s Zeitschrift für physiologische Chemie
Y1  - 1981
U6  - http://dx.doi.org/10.1515/bchm2.1981.362.1.821
SN  - 1437-4315
SN  - 0018-4888
VL  - 362
IS  - 1
SP  - 821
EP  - 828
ER  - 
TY  - JOUR
A1  - Hafidi, Youssef
A1  - El Hatka, Hicham
A1  - Schmitz, Dominik
A1  - Krauss, Manuel
A1  - Pettrak, Jürgen
A1  - Biel, Markus
A1  - Ittobane, Najim
T1  - Sustainable soil additives for water and micronutrient supply: swelling and chelating properties of polyaspartic acid hydrogels utilizing newly developed crosslinkers
JF  - Gels
N2  - Drought and water shortage are serious problems in many arid and semi-arid regions. This problem is getting worse and even continues in temperate climatic regions due to climate change. To address this problem, the use of biodegradable hydrogels is increasingly important for the application as water-retaining additives in soil. Furthermore, efficient (micro-)nutrient supply can be provided by the use of tailored hydrogels. Biodegradable polyaspartic acid (PASP) hydrogels with different available (1,6-hexamethylene diamine (HMD) and L-lysine (LYS)) and newly developed crosslinkers based on diesters of glycine (GLY) and (di-)ethylene glycol (DEG and EG, respectively) were synthesized and characterized using Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) and regarding their swelling properties (kinetic, absorbency under load (AUL)) as well as biodegradability of PASP hydrogel. Copper (II) and zinc (II), respectively, were loaded as micronutrients in two different approaches: in situ with crosslinking and subsequent loading of prepared hydrogels. The results showed successful syntheses of di-glycine-ester-based crosslinkers. Hydrogels with good water-absorbing properties were formed. Moreover, the developed crosslinking agents in combination with the specific reaction conditions resulted in higher water absorbency with increased crosslinker content used in synthesis (10% vs. 20%). The prepared hydrogels are candidates for water-storing soil additives due to the biodegradability of PASP, which is shown in an exemple. The incorporation of Cu(II) and Zn(II) ions can provide these micronutrients for plant growth.
KW  - micronutrients
KW  - swelling properties
KW  - biodegradable polymers
KW  - hydrogels
KW  - superabsorbent polymers
KW  - glycine
KW  - polyaspartic acid
Y1  - 2024
U6  - http://dx.doi.org/10.3390/gels10030170
SN  - 2310-2861
VL  - 10
IS  - 3
SP  - Artikel 170
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Jakob, Felix
A1  - Martinez, Ronny
A1  - Mandawe, John
A1  - Hellmuth, Hendrik
A1  - Siegert, Petra
A1  - Maurer, Karl-Heinz
A1  - Schwaneberg, Ulrich
T1  - Surface charge engineering of a Bacillus gibsonii subtilisin protease
JF  - Applied microbiology and biotechnology
Y1  - 2013
SN  - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print)
VL  - Vol. 97
IS  - Iss. 15
SP  - 6793
EP  - 6802
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Al-Kaidy, Huschyar
A1  - Tippkötter, Nils
T1  - Superparamagnetic hydrophobic particles as shell material for digital microfluidic droplets and proof-of-principle reaction assessments with immobilized laccase
JF  - Engineering in Life Sciences
N2  - In the field of biotechnology and molecular biology, the use of small liquid volumes has significant advantages. In particular, screening and optimization runs with acceptable amounts of expensive and hardly available catalysts, reagents, or biomolecules are feasible with microfluidic technologies. The presented new microfluidic system is based on the inclusion of small liquid volumes by a protective shell of magnetizable microparticles. Hereby, discrete aqueous microreactor drops with volumes of 1–30 μL can be formed on a simple planar surface. A digital movement and manipulation of the microreactor is performed by overlapping magnetic forces. The magnetic forces are generated by an electrical coil matrix positioned below a glass plate. With the new platform technology, several discrete reaction compartments can be moved simultaneously on one surface. Due to the magnetic fields, the reactors can even be merged to initiate reactions by mixing or positioned above surface-immobilized catalysts and then opened by magnetic force. Comparative synthesis routes of the magnetizable shell particles and superhydrophobic glass slides including their performance and stability with the reaction platform are described. The influence of diffusive mass transport during the catalyzed reaction is discussed by evaluation finite element model of the microreactor. Furthermore, a first model dye reaction of the enzyme laccase has been established.
Y1  - 2016
U6  - http://dx.doi.org/10.1002/elsc.201400124
VL  - 16
IS  - 3
SP  - 222
EP  - 230
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
T1  - Superabsorbed alcohol dehydrogenase—a new catalyst for asymmetric reductions
JF  - Biotechnology Letters. 31 (2009), H. 11
Y1  - 2009
SN  - 0141-5492
SP  - 1717
EP  - 1721
ER  -