TY  - JOUR
A1  - Bergs, Michel
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W.
A1  - Konow, Christopher
A1  - Völkering, Georg
A1  - Pude, Ralf
A1  - Schulze, Margit
T1  - Lignins isolated via catalyst-free organosolv pulping from Miscanthus x giganteus, M. sinensis, M. robustus and M. nagara: a comparative study
JF  - Molecules
N2  - As a low-input crop, Miscanthus offers numerous advantages that, in addition to agricultural applications, permits its exploitation for energy, fuel, and material production. Depending on the Miscanthus genotype, season, and harvest time as well as plant component (leaf versus stem), correlations between structure and properties of the corresponding isolated lignins differ. Here, a comparative study is presented between lignins isolated from M. x giganteus, M. sinensis, M. robustus and M. nagara using a catalyst-free organosolv pulping process. The lignins from different plant constituents are also compared regarding their similarities and differences regarding monolignol ratio and important linkages. Results showed that the plant genotype has the weakest influence on monolignol content and interunit linkages. In contrast, structural differences are more significant among lignins of different harvest time and/or season. Analyses were performed using fast and simple methods such as nuclear magnetic resonance (NMR) spectroscopy. Data was assigned to four different linkages (A: β-O-4 linkage, B: phenylcoumaran, C: resinol, D: β-unsaturated ester). In conclusion, A content is particularly high in leaf-derived lignins at just under 70% and significantly lower in stem and mixture lignins at around 60% and almost 65%. The second most common linkage pattern is D in all isolated lignins, the proportion of which is also strongly dependent on the crop portion. Both stem and mixture lignins, have a relatively high share of approximately 20% or more (maximum is M. sinensis Sin2 with over 30%). In the leaf-derived lignins, the proportions are significantly lower on average. Stem samples should be chosen if the highest possible lignin content is desired, specifically from the M. x giganteus genotype, which revealed lignin contents up to 27%. Due to the better frost resistance and higher stem stability, M. nagara offers some advantages compared to M. x giganteus. Miscanthus crops are shown to be very attractive lignocellulose feedstock (LCF) for second generation biorefineries and lignin generation in Europe.
Y1  - 2021
U6  - https://doi.org/10.3390/molecules26040842
SN  - 1420-3049
N1  - Special Issue Lignin – A Natural Resource with Huge Potential https://www.mdpi.com/journal/molecules/special_issues/lignin_natural
VL  - 26
IS  - 4
PB  - MDPI
CY  - Basel
ER  - 
TY  - GEN
A1  - Poth, S.
A1  - Monzon, M.
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Lignocellulose-Bioraffinerie: Simultane Verzuckerung und Fermentation
T2  - Chemie Ingenieur Technik
N2  - Die am häufigsten genutzten Rohstoffe für die Produktion von Treibstoffen und Chemikalien sind fossilen Ursprungs. Da diese limitiert sind, werden im Hinblick auf die Nachhaltigkeit alternative, erneuerbare Rohstoffquellen intensiv untersucht. Vielversprechend in diesem Kontext sind die in Lignocellulose enthaltenen Zucker, die beispielsweise zur Produktion von Ethanol genutzt werden können. In der Regel sind für eine Lig-nocellulose-Bioraffinerie mehrere Prozessschritte notwendig: Vorbehandlung, Verzuckerung und Fermentation. Um diesen Prozess einfacher zu gestalten, ist es möglich, die Verzuckerung und die Fermentation in einem Schritt durchzuführen (SSF). Als Substrat wird hier Cellulose-Faserstoff verwendet, der durch das Organosolv-Verfahren aufgeschlossen wurde. Die Hydrolyse erfolgt mit kommerziell erhältlichen Enzymen und für die Fermentation zu Ethanol werden zwei Hefen verwendet. Beim SSF-Verfahren konnte, im Vergleich zur entkoppelten Verfahrensweise, trotz bestehender Unterschiede in den Temperatur-Optima von Enzymen und Hefen eine Steigerung in der Ethanol-Ausbeute von 0,15 auf 0,2 gg⁻¹ beobachtet werden. Um wirtschaftliche Ausbeuten und Konzentrationen des Produkts erzielen zu können, ist es notwendig den Prozess weiter zu optimieren. Im Einzelfall muss überprüft werden, ob diese Verfahrensweise auch für die Produktion anderer interessanter Stoffe (wie Itaconsäure, Bernsteinsäure) geeignet ist.
KW  - Lignocellulose-Bioraffinerie
KW  - Prozessintegration
Y1  - 2010
U6  - https://doi.org/10.1002/cite.201050360
N1  - ProcessNet-Jahrestagung 2010 und 28. DECHEMA-Jahrestagung der Biotechnologen, 21. - 23. September 2010, Eurogress Aachen
VL  - 82
IS  - 9
SP  - 1568
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Duwe, A.
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Lignocellulose-Biorefinery: Ethanol-Focused
T2  - Biorefineries
N2  - The development prospects of the world markets for petroleum and other liquid fuels are diverse and partly contradictory. However, comprehensive changes for the energy supply of the future are essential. Notwithstanding the fact that there are still very large deposits of energy resources from a geological point of view, the finite nature of conventional oil reserves is indisputable. To reduce our dependence on oil, the EU, the USA, and other major economic zones rely on energy diversification. For this purpose, alternative materials and technologies are being sought, and is most obvious in the transport sector. The objective is to progressively replace fossil fuels with renewable and more sustainable fuels. In this respect, biofuels have a pre-eminent position in terms of their capability of blending with fossil fuels and being usable in existing cars without substantial modification. Ethanol can be considered as the primary renewable liquid fuel. In this chapter enzymes, micro-organisms, and processes for ethanol production based on renewable resources are described.
KW  - Bioethanol
KW  - Biorefinery
KW  - Lignocellulose feedstook
Y1  - 2018
U6  - https://doi.org/10.1007/10_2016_72
N1  - Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE,volume 166)
SP  - 177
EP  - 215
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Poth, Sebastian
A1  - Monzon, Magaly
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Lignocellulosic biorefinery : process integration of hydrolysis and fermentation
T2  - Proceedings / 11th European Workshop on Lignocellulosics and Pulp : August 16 - 19, 2010, Hamburg, Germany
Y1  - 2010
SP  - 65
EP  - 68
PB  - vTi
CY  - Hamburg
ER  - 
TY  - JOUR
A1  - Poth, Sebastian
A1  - Monzon, Magaly
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Lignocellulosic biorefinery: Process integration of hydrolysis and fermentation (SSF process)
JF  - Holzforschung
N2  - The aim of the present work is the process integration and the optimization of the enzymatic hydrolysis of wood and the following fermentation of the products to ethanol. The substrate is a fiber fraction obtained by organosolv pre-treatment of beech wood. For the ethanol production, a co-fermentation by two different yeasts (Saccharomyces cerevisiae and Pachysolen tannophilus) was carried out to convert glucose as well as xylose. Two approaches has been followed: 1. A two step process, in which the hydrolysis of the fiber fraction and the fermentation to product are separated from each other. 2. A process, in which the hydrolysis and the fermentation are carried out in one single process step as simultaneous saccharification and fermentation (SSF). Following the first approach, a yield of about 0.15 g ethanol per gram substrate can be reached. Based on the SSF, one process step can be saved, and additionally, the gained yield can be raised up to 0.3 g ethanol per gram substrate.
Y1  - 2011
N1  - 11th EWLP, Hamburg, Germany, August 16–19, 2010
VL  - 65
IS  - 5
SP  - 633
EP  - 637
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Engel, Mareike
A1  - Thieringer, Julia
A1  - Tippkötter, Nils
T1  - Linking bioprocess engineering and electrochemistry for sustainable biofuel production
T2  - Young Researchers Symposium, YRS 2016. Proceedings
N2  - Electromicrobial engineering is an emerging, highly interdisciplinary research area linking bioprocesses with electrochemistry. In this work, microbial electrosynthesis (MES) of biobutanol is carried out during acetone-butanol-ethanol (ABE) fermentations with Clostridium acetobutylicum. A constant electric potential of −600mV (vs. Ag/AgCl) with simultaneous addition of the soluble redox mediator neutral red is used in order to study the electron transfer between the working electrode and the bacterial cells. The results show an earlier initiation of solvent production for all fermentations with applied potential compared to the conventional ABE fermentation. The f inal butanol concentration can be more than doubled by the application of a negative potential combined with addition of neutral red. Moreover a higher biofilm formation on the working electrode compared to control cultivations has been observed. In contrast to previous studies, our results also indicate that direct electron transfer (DET) might be possible with C. acetobutylicum. The presented results make microbial butanol production economically attractive and therefore support the development of sustainable production processes in the chemical industry aspired by the “Centre for resource-efficient chemistry and raw material change” as well as the the project “NanoKat” working on nanostructured catalysts in Kaiserslautern.
Y1  - 2016
N1  - Young Researchers Symposium, YRS 2016, 14th - 15th April 2016, Fraunhofer-Zentrum Kaiserslautern
SP  - 49
EP  - 53
PB  - Fraunhofer Verlag
CY  - Karlsruhe
ER  - 
TY  - PAT
A1  - Banowski, Bernhard
A1  - Wadle, Armin
A1  - Siegert, Petra
A1  - Sättler, Andrea
T1  - Lipase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift]
T1  - Lipase inhibitors in deodorants and antiperspirants [Europäische Patentanmeldung]
Y1  - 2004
SP  - 1
EP  - 22
PB  - Deutsches Patent- und Markenamt / Europäisches Patentamt
CY  - München / Den Hague
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Hörstermann, D.
A1  - Gyngell, M. L.
A1  - Merboldt, K.-D.
T1  - Localized Proton MRS of Acute and Chronic Gyperglycemia in Rat Brain in vivo / D. Hörstermann, F. Prielmeier , M. L. Gyngell, K.-D. Merboldt, W. Hänicke, J. Frahm
JF  - Book of Abstracts, SMRM, 11th Annual Meeting Berlin
Y1  - 1992
N1  - Society of Magnetic Resonance in Medicine
SP  - 2740
ER  - 
TY  - CHAP
A1  - Tippkötter, Nils
A1  - Möhring, Sophie
A1  - Roth, Jasmine
A1  - Wulfhorst, Helene
T1  - Logistics of lignocellulosic feedstocks: preprocessing as a preferable option
T2  - Biorefineries
N2  - In comparison to crude oil, biorefinery raw materials are challenging in concerns of transport and storage. The plant raw materials are more voluminous, so that shredding and compacting usually are necessary before transport. These mechanical processes can have a negative influence on the subsequent biotechnological processing and shelf life of the raw materials. Various approaches and their effects on renewable raw materials are shown. In addition, aspects of decentralized pretreatment steps are discussed. Another important aspect of pretreatment is the varying composition of the raw materials depending on the growth conditions. This problem can be solved with advanced on-site spectrometric analysis of the material.
KW  - Analytics
KW  - Decentral
KW  - Mechanical
KW  - On-site
KW  - Pre-treatment
Y1  - 2019
SN  - 978-3-319-97117-9
SN  - 978-3-319-97119-3
U6  - https://doi.org/10.1007/10_2017_58
N1  - Advances in biochemical engineering/biotechnology ; Vol. 166
SP  - 43
EP  - 68
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Meiners, Klaus
A1  - Baumann, Marcus
T1  - Lokale Beiträge zum globalen Klimaschutz
JF  - Wechselwirkung : Wissenschaft & vernetztes Denken
Y1  - 1997
SN  - 0172-1623
VL  - 19
IS  - 84
SP  - 6
EP  - 12
ER  - 
TY  - RPRT
A1  - Tippkötter, Nils
T1  - Lokale Vorbehandlung nachwachsender Rohstoffe für Bioraffinerien (BioSats) : Schlussbericht zum Vorhaben : Laufzeit: 01.03.2012 bis 30.04.2017
Y1  - 2018
U6  - https://doi.org/10.2314/GBV:1024204243
ER  - 
TY  - GEN
A1  - Tippkötter, Nils
A1  - Pasteur, A.
A1  - Ulber, Roland
T1  - Magnetisch abtrennbare Gold-Nanopartikel zur katalytischen Zuckeroxidation
T2  - Chemie Ingenieur Technik
N2  - Glucose ist ein primäres Zwischenprodukt der Verarbeitung nachwachsender Rohstoffe, wie z. B. Cellulose. Die wertsteigernde Weiterverarbeitung des Monosaccharids erfolgt häufig in Form vonFermentationsprozessen, jedoch kann der Rohstoff auch für zahlreiche chemische Verarbeitungsstufen genutzt werden. Ein großtechnisch relevanter Prozess ist die Herstellung von Gluconsäure (GS), die u. a. als Nahrungsmittelzusatz (E 574) eingesetzt wird. Die Darstellung der Säure erfolgt durch Oxidation von Glucose mit magnetisierbarem Gold-Nano-Katalysator. Die Rückgewinnung des Katalysators aus der Reaktionslösung wurde unter Einwirkung eines Magnetfeldgradienten verwirklicht. Die Synthese der magnetischen Goldkatalysatoren (sowohl Trägerpartikel als auch Gold-Nanopartikel) wurde durch nass-chemische Fällungsreaktionen durchgeführt. Die Charakteristiken der neuen Materialen konnte durch Messungen des PCD-Potenzials, Laserbeugung und REM/EDX untersucht werden. So wurden u. a. Partikeldurchmesser von 25 lm und ein Goldgehaltvon 1,03 % ermittelt. Weiterhin wurden für die Goldkatalysatoren optimale Reaktionsbedingungen für die Glucoseoxidation im geregelten Rührkesselreaktor etabliert. Hierdurch konnten eine Produktselektivität von 100 % und eine Wiederverwendbarkeit der Partikel über mindestens zehn Zyklen erreicht werden.
Y1  - 2012
U6  - https://doi.org/10.1002/cite.201250393
SN  - 0009-286X
SN  - 1522-2640 (eISSN)
N1  - ProcessNet-Jahrestagung 2012 und 30. DECHEMA-Jahrestagung der Biotechnologen, 10. – 13. September 2012, Karlsruhe
VL  - 84
IS  - 8
SP  - 1328
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Magnetische Mikro- und Nanopartikel für Medizin und Biotechnik
JF  - Wässrige Kunststoffdispersionen und ihre Anwendung : Fachbereich Angewandte Naturwissenschaften und Technik / Fachhochschule Aachen. [Schriftleitung: Thomas Mang ...]
Y1  - 2005
N1  - FH-Texte ; 71 ; Makromolekulares Kolloquium FH Aachen
SP  - 137
EP  - 150
PB  - Fachhochschule Aachen
CY  - Aachen
ER  - 
TY  - GEN
A1  - Hering, T.
A1  - Pasteur, A.
A1  - Wollny, S.
A1  - Ulber, Roland
A1  - Tippkötter, Nils
T1  - Magnetische Separation von Gold-Nanopartikeln zur Gluconsäure-Produktion durch Hochgradient-Magnetseparation im Labormaßstab
T2  - Chemie Ingenieur Technik
N2  - Bei der Verarbeitung nachwachsender Rohstoffe entsteht aus Cellulose oder Stärke u. a. das wichtige Produkt Glucose. Diese niedermolekulare Kohlenhydratquelle wird üblicherweise als Substrat für biotechnologische und chemische Synthesen verwendet. Ein wirtschaftlich interessantes Oxidationsprodukt der Glucose ist Gluconsäure, die beispielsweise als Lebensmittelzusatzstoff (E 574), in der Medizin und Metallindustrie Verwendung findet. Die Umsetzung des Monosaccharids zu Gluconsäure erfolgt entweder durch mikrobielle Fermentation oder der Oxidation an heterogenen Katalysatoren. Die Zielsetzung der Studie ist die Untersuchung der Glucoseoxidation an magnetisierbaren Gold-Nanopartikeln unter nachfolgender Bypass-Separation des Katalysators mittels einer neuen Mini-HGMS-Einheit (Hochgradient-Magnetseparation). Dieser Filtertyp ermöglicht die selektive Trennung magnetischer Partikel aus Suspensionen mit hohem Feststoffgehalt oder Viskosität. Erste Ergebnisse zeigen eine Beladungskapazität des selbstkonstruierten Mini-HGMS von 550 mg goldbeschichteter magnetisierbarer Nanopartikel. Die Oxidation erfolgt bei einem pH-Wertvon 9, bei 40 °C und mit 100 mM Glucose in einem begasten Rührkesselreaktor. Das System soll zukünftig zum Katalysatorrecycling von hochviskosen und Feststoffbelasteten Produktströmen aus Bioraffinerien eingesetzt werden.
Y1  - 2014
U6  - https://doi.org/10.1002/cite.201450265
SN  - 0009-286X
SN  - 1522-2640 (eISSN)
N1  - ProcessNet-Jahrestagung 2014 und 31. DECHEMA-Jahrestagung der Biotechnologen, 30. September - 2. Oktober 2014, Eurogress Aachen
VL  - 86
IS  - 9
SP  - 1501
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Wollny, S.
A1  - Kampeis, P.
A1  - Oster, J.
A1  - Schneider, H.
A1  - Ulber, Roland
T1  - Magnetseparation von Proteinen : Separation von Zielmolekülen durch hochselektive Aptamere
JF  - GIT Labor-Fachzeitschrift
N2  - Durch die Kombination von Oligonukleotid-Liganden (Aptameren) hoher Bindungsaffinitäten
mit hochselektiv abtrennbaren magnetisierbaren Mikropartikeln
wird eine einstufige Separation von Zielmolekülen aus mikrobiologischen
Produktionsansätzen möglich. Die Aptamere werden hierfür reversibel
auf den Partikeloberflächen gebunden und für die spezifische Isolierung von
Bioprodukten eingesetzt. Die Abtrennung der beladenen Partikel erfolgt
durch einen neuen Rotor-Stator-Separator mit Hochgradient-Magnetfeld.
Y1  - 2011
VL  - 55
IS  - 10
SP  - 666
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schmidt, Aaron C.
A1  - Turgut, Hatice
A1  - Le, Dao
A1  - Beloqui, Ana
A1  - Delaittre, Guillaume
T1  - Making the best of it: nitroxide-mediated polymerization of methacrylates via the copolymerization approach with functional styrenics
JF  - Polymer Chemistry
N2  - The SG1-mediated solution polymerization of methyl methacrylate (MMA) and oligo(ethylene glycol) methacrylate (OEGMA, Mₙ = 300 g mol⁻¹) in the presence of a small amount of functional/reactive styrenic comonomer is investigated. Moieties such as pentafluorophenyl ester, triphenylphosphine, azide, pentafluorophenyl, halide, and pyridine are considered. A comonomer fraction as low as 5 mol% typically results in a controlled/living behavior, at least up to 50% conversion. Chain extensions with styrene for both systems were successfully performed. Variation of physical properties such as refractive index (for MMA) and phase transition temperature (for OEGMA) were evaluated by comparing to 100% pure homopolymers. The introduction of an activated ester styrene derivative in the polymerization of OEGMA allows for the synthesis of reactive and hydrophilic polymer brushes with defined thickness. Finally, using the example of pentafluorostyrene as controlling comonomer, it is demonstrated that functional PMMA-b-PS are able to maintain a phase separation ability, as evidenced by the formation of nanostructured thin films.
Y1  - 2020
U6  - https://doi.org/10.1039/C9PY01458F
VL  - 11
IS  - 2
SP  - 593
EP  - 604
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Jahnke, J.
T1  - Marine Planktonalgen der Arktis I. Die Haptophycee Phaeocystis pouchetii / Baumann, M. ; Jahnke, J.
JF  - Mikrokosmos. 75 (1986), H. 9
Y1  - 1986
SN  - 0026-3680
SP  - 262
EP  - 265
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Krämer, M.
T1  - Marine Planktonalgen der Arktis II. Diatomeen / Baumann, M. ; Krämer, M.
JF  - Mikrokosmos. 75 (1986), H. 10
Y1  - 1986
SN  - 0026-3680
SP  - 306
EP  - 310
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Künsch, M.
A1  - Stahlberg, R.
A1  - Steiger, F.
T1  - Massen- und Energiebilanz des Thermoselect-Verfahrens
JF  - Thermoselect-Verfahren zur Ent- und Vergasung von Abfällen / Franz J. Schweitzer [Hrsg.]
Y1  - 1994
SN  - 3-924511-47-0
PB  - EF-Verl. für Energie- u. Umwelttechnik
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Stahlberg, R.
A1  - Weisenburger, P.
A1  - Steiger, F.
T1  - Massen- und Energiebilanzen unter Einbeziehung der Untersuchungen an der Thermoselect-Anlage Fondotoce (Italien). Stahlberg, R.; Feuerriegel, U.; Weisenburger, P.; Steiger, F.
JF  - Thermoselect : der neue Weg, Restmüll umweltgerecht zu behandeln ; [Tagungsband zur Fachtagung Thermoselect am 19. Januar 1995 in Rastatt/Baden] / Günther Häßler. 2. durchges. und erw. Aufl.
Y1  - 1995
SN  - 3-9803665-4-5
N1  - Fachtagung THERMOSELECT ; (1995, Rastatt) ; Fachtagung Thermoselect ; (1995.01.19 : ; Rastatt)
SP  - 55
EP  - 84
PB  - Goerner
CY  - Karlsruhe
ER  - 
TY  - JOUR
A1  - Liu, Z.
A1  - Schaap, K. S.
A1  - Ballemans, L.
A1  - de Blois, E.
A1  - Rohde, M.
A1  - Paulßen, Elisabeth
T1  - Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system
JF  - Dalton Transactions
Y1  - 2017
U6  - https://doi.org/10.1039/C7DT01830D
SN  - 1477-9234
VL  - 46
IS  - 42
SP  - 14669
EP  - 14676
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Grosse, Joachim O.
A1  - Grossmann, Matthias
A1  - Janke, Heinz Peter
A1  - Arndt, Patrick
A1  - Koch, Sabine
A1  - Epple, Matthias
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation
JF  - Journal of Biomaterials Applications
Y1  - 2017
U6  - https://doi.org/10.1177/0885328217723178
SN  - 1530-8022
VL  - 32
IS  - 3
SP  - 321
EP  - 330
PB  - Sage
CY  - London
ER  - 
TY  - GEN
A1  - Rothkranz, Berit
A1  - Krafft, Simone
A1  - Tippkötter, Nils
T1  - Media optimization for sustainable fuel production: How to produce biohydrogen from renewable resources with Thermotoga neapolitana
T2  - Chemie Ingenieur Technik
N2  - Hydrogen is playing an increasingly important role in research and politics as an energy carrier of the future. Since hydrogen has commonly been produced from methane by steam reforming, the need for climate-friendly, alternative production routes is emerging. In addition to electrolysis, fermentative routes for the production of so-called biohydrogen are "green" alternatives. The application of microorganisms offers the advantage of sustainable production from renewable resources using easily manageable technologies. In this project, the hyperthermophilic, anaerobic microorganism Thermotoga neapolitana is used for the productio nof biohydrogen from renewable resources. The enzymatically hydrolyzed resources were used in fermentation leading to yield coefficients of 1.8 mole H₂ per mole glucose when using hydrolyzed straw and ryegrass supplemented with medium, respectively. These results are similar to the hydrogen yields when using Thermotoga basal medium with glucose (TBGY) as control group. In order to minimize the supplementation of the hydrolysate and thus increase the economic efficiency of the process, the essential media components were identified. The experiments revealed NaCl, KCl, and glucose as essential components for cell growth as well as biohydrogen production. When excluding NaCl, a decrease of 96% in hydrogen production occured.
Y1  - 2022
U6  - https://doi.org/10.1002/cite.202255305
SN  - 0009-286X
SN  - 1522-2640 (eISSN)
N1  - ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 together with 13th ESBES Symposium 2022, 12. - 15. September 2022, Eurogress Aachen
VL  - 94
IS  - 9
SP  - 1298
EP  - 1299
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Inagaki, Akiko
A1  - Sleddens-Linkels, Esther
A1  - Wassenaar, Evelyne
A1  - Ooms, Marja
A1  - Cappellen, Wiggert A. van
A1  - Hoeijmakers, Jan H. J.
A1  - Seibler, Jost
A1  - Vogt, Thomas F.
A1  - Shin, Myung K.
A1  - Grootegoed, J. Anton
A1  - Baarends, Willy M.
T1  - Meiotic functions of RAD18
JF  - Journal of Cell Science
Y1  - 2011
U6  - https://doi.org/10.1242/jcs.081968
SN  - 1477-9137
VL  - 124
IS  - 16
SP  - 2837
EP  - 2850
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Trapp, Svenja
A1  - Lammers, Tom
A1  - Engudar, Gokce
A1  - Hoehr, Cornelia
A1  - Denkova, Antonia G.
A1  - Paulßen, Elisabeth
A1  - de Kruijff, Robin M.
T1  - Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop
JF  - EJNMMI Radiopharmacy and Chemistry
KW  - Microfluidic solvent extraction
KW  - Ga-68
KW  - Cyclotron production
KW  - Medical radionuclide production
KW  - Metal contaminants
Y1  - 2023
U6  - https://doi.org/10.1186/s41181-023-00195-2
SN  - 2365-421X
VL  - 2023
IS  - 8, Article number: 9
SP  - 1
EP  - 14
PB  - Springer Nature
ER  - 
TY  - JOUR
A1  - Harish, Ajay B.
A1  - Wriggers, Peter
A1  - Jungk, Juliane
A1  - Hojdis, Nils
A1  - Recker, Carla
T1  - Mesoscale Constitutive Modeling of Non-Crystallizing Filled Elastomers
JF  - Computational Mechanics
N2  - Elastomers are exceptional materials owing to their ability to undergo large deformations before failure. However, due to their very low stiffness, they are not always suitable for industrial applications. Addition of filler particles provides reinforcing effects and thus enhances the material properties that render them more versatile for applications like tyres etc. However, deformation behavior of filled polymers is accompanied by several nonlinear effects like Mullins and Payne effect. To this day, the physical and chemical changes resulting in such nonlinear effect remain an active area of research. In this work, we develop a heterogeneous (or multiphase) constitutive model at the mesoscale explicitly considering filler particle aggregates, elastomeric matrix and their mechanical interaction through an approximate interface layer. The developed constitutive model is used to demonstrate cluster breakage, also, as one of the possible sources for Mullins effect observed in non-crystallizing filled elastomers.
Y1  - 2016
U6  - https://doi.org/10.1007/s00466-015-1251-1
SN  - 1432-0924
VL  - 57
SP  - 653
EP  - 677
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Elbers, Gereon
A1  - Richter, J.
T1  - Messung kraftfahrzeugbedingter Rußimmissionen
JF  - Staub, Reinhaltung der Luft : air quality control. 54 (1994)
Y1  - 1994
SN  - 0039-0771
SP  - 19
ER  - 
TY  - JOUR
A1  - Elbers, Gereon
T1  - Messung von Ruß in der Außenluft - Praktische Erfahrungen und Meßergebnisse aus NRW
JF  - Aktuelle Aufgaben der Messtechnik in der Luftreinhaltung : Kolloquium Heidelberg, 2. bis 4. Juni 1993 / Kommission Reinhaltung der Luft im VDI und DIN
Y1  - 1993
SN  - 3-18-091059-3
N1  - VDI-Berichte ; 1059
SP  - 337
PB  - VDI-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Bongaerts, Johannes
A1  - Krämer, Marco
A1  - Müller, Ulrike
A1  - Raeven, Leon
A1  - Wubbolts, Marcel
T1  - Metabolic engineering for microbial production of aromatic amino acids and derived compounds
JF  - Metabolic engineering
Y1  - 2001
SN  - 1096-7184 (E-Journal); 1096-7176 (Print)
VL  - Vol. 3
IS  - Iss. 4
SP  - 289
EP  - 300
ER  - 
TY  - JOUR
A1  - Krämer, Marco
A1  - Bongaerts, Johannes
A1  - Bovenberg, Roel
A1  - Kremer, Susanne
A1  - Müller, Ulrike
A1  - Orf, Sonja
A1  - Wubbolts, Marcel
A1  - Raeven, Leon
T1  - Metabolic engineering for microbial production of shikimic acid
JF  - Metabolic engineering
Y1  - 2003
SN  - 1096-7184 (E-Journal); 1096-7176 (Print)
VL  - Vol. 5
IS  - Iss. 4
SP  - 277
EP  - 283
ER  - 
TY  - JOUR
A1  - Müller, Ulrike
A1  - Bongaerts, Johannes
A1  - Bovenberg, Roel
A1  - Jossek, Ralf
A1  - Krämer, Marco
A1  - Linnemann, J.
A1  - Müschen, S.
A1  - Ritterbecks, S.
A1  - Sprenger, G.
A1  - Wubbolts, Marcel
T1  - Metabolic engineering to produce fine chemicals in Escherichia coli
JF  - Mededelingen van de Faculteit Landbouwwetenschappen, Rijksuniversiteit Gent
Y1  - 2001
SN  - 0035-533x
VL  - 66 (3a)
SP  - 215
EP  - 217
ER  - 
TY  - JOUR
A1  - Bongaerts, Johannes
A1  - Bovenberg, Roel
A1  - Krämer, Marco
A1  - Müller, Ulrike
A1  - Raeven, Leon
A1  - Wubbolts, Marcel
T1  - Metabolic engineering to produce fine chemicals in Escherichia coli
JF  - Chemie - Ingenieur - Technik (CIT)
Y1  - 2002
SN  - 1522-2640 (E-Journal); 0009-286X (Print)
N1  - Printausg. in der Bibliothek vorhanden: 63 ZS 022
VL  - Vol. 74
IS  - Iss. 5
SP  - 694
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Schiffels, Johannes
A1  - Herrera, Cony N.
A1  - Schelden, Maximilian
A1  - Selmer, Thorsten
A1  - Poghossian, Arshak
A1  - Baumann, Marcus
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Metabolic responses of Escherichia coli upon glucose pulses captured by a capacitive field-effect sensor
JF  - Physica Status Solidi (A)
N2  - Living cells are complex biological systems transforming metabolites taken up from the surrounding medium. Monitoring the responses of such cells to certain substrate concentrations is a challenging task and offers possibilities to gain insight into the vitality of a community influenced by the growth environment. Cell-based sensors represent a promising platform for monitoring the metabolic activity and thus, the “welfare” of relevant organisms. In the present study, metabolic responses of the model bacterium Escherichia coli in suspension, layered onto a capacitive field-effect structure, were examined to pulses of glucose in the concentration range between 0.05 and 2 mM. It was found that acidification of the surrounding medium takes place immediately after glucose addition and follows Michaelis–Menten kinetic behavior as a function of the glucose concentration. In future, the presented setup can, therefore, be used to study substrate specificities on the enzymatic level and may as well be used to perform investigations of more complex metabolic responses. Conclusions and perspectives highlighting this system are discussed.
Y1  - 2013
U6  - https://doi.org/10.1002/pssa.201200900
SN  - 0031-8965
VL  - 210
IS  - 5
SP  - 926
EP  - 931
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wilming, Anja
A1  - Begemann, Jens
A1  - Kuhne, Stefan
A1  - Regestein, Lars
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Maurer, Karl-Heinz
A1  - Büchs, Jochen
T1  - Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations
JF  - Biochemical engineering journal
Y1  - 2013
SN  - 1873-295X (E-Journal); 1369-703X (Print)
VL  - Vol. 73
SP  - 29
EP  - 37
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - PAT
A1  - O'Connell, Timothy
A1  - Siegert, Petra
A1  - Maurer, Karl-Heinz
A1  - Schiedel, Marc-Steffen
A1  - Vockenroth, Inga Kerstin
T1  - Method for improving the cleaning action of a detergent or cleaning agent [Internationale Patentanmeldung]
T1  - Verfahren zur Verbesserung der Reinigungsleistung eines Wasch- oder Reinigungsmittels
Y1  - 2010
SP  - 1
EP  - 15
PB  - WIPO
CY  - Genf
ER  - 
TY  - PAT
A1  - Stadtmüller, Ralf
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Method for production of single-stranded macronucleotides
N2  - The invention relates to a method for production of single-stranded macronucleotides by amplifying and ligating an extended monomeric single-stranded target nucleic acid sequence (targetss) into a repetitive cluster of double-stranded target nucleic acid sequences (targetds), and subsequently cloning the construct into a vector (aptagene vector). The aptagene vector is transformed into host cells for replication of the aptagene and isolated in order to optain single-stranded target sequences (targetss). The invention also relates to single-stranded nucleic acids, produced by a method of the invention.
Y1  - 2015
N1  - Patent auch unter EP2774996, EP2774996, US2017145460 und US9944966 veröffentlicht.
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Pinkenburg, Olaf
T1  - Method of cloning at least one nucleic acid molecule of interest using type IIS restriction endonucleases, and corresponding cloning vectors, kits and system using type IIS restriction endonucleases / Selmer, Thorsten ; Pinkenburg, Olaf
Y1  - 2008
N1  - Patent No. WO 2008095927  	A1  	Aug 14, 2008
ER  - 
TY  - CHAP
A1  - Engel, M.
A1  - Thieringer, J.
A1  - Tippkötter, Nils
T1  - Microbial electrosynthesis for sustainable biobutanol production
T2  - New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany
Y1  - 2016
SP  - 77
EP  - 78
PB  - DECHEMA
CY  - Frankfurt am Main
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Raue, Markus
A1  - Schusser, Sebastian
A1  - Jeitner, C.
A1  - Breuer, L.
A1  - Wagner, P.
A1  - Poghossian, Arshak
A1  - Förster, Arnold
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
T1  - Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films
JF  - Physica Status Solidi  (a)
N2  - Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3–12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100763
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 839
EP  - 845
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - PAT
A1  - Berg, Gabriele
A1  - Bessler, Cornelius
A1  - Gerlach, Jochen
A1  - Gübitz, Georg
A1  - Heumann, Sonja
A1  - Karl, Wolfgang
A1  - Maurer, Karl-Heinz
A1  - Remler, Peter
A1  - Ribitsch, Doris
A1  - Schwab, Helmut
A1  - Siegert, Petra
A1  - Wieland, Susanne
T1  - Mittel enthaltend Proteasen aus Stenotrophomonas maltophilia [Offenlegungsschrift]
T1  - Agents containing proteases from Stenotrophomonas maltophilia [Europäische Patentanmeldung / US Patentanmeldung / Internationale Patentanmeldung]
Y1  - 2009
SP  - 1
EP  - 47
PB  - Deutsches Patent- und Markenamt / Europäisches Patentamt / USPTO / WIPO
CY  - München / Den Hague / Washington / Genf
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - McEwan, Jillian
A1  - Beuger, Vincent
A1  - Stanley, Lesley A.
A1  - Rode, Anja
A1  - Wolf, C. Roland
T1  - Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
JF  - Molecular Pharmacology
N2  - The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.
Y1  - 2012
U6  - https://doi.org/10.1124/mol.111.075192
SN  - 1521-0111
VL  - 81
IS  - 1
SP  - 63
EP  - 72
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Kricheldorf, Hans R.
A1  - Au, M.
T1  - Models of molecular evolution. 2. Stereospecificity of dipeptide syntheses by means of cyanamides and carbodiimides / Kricheldorf, Hans R. ; Au, M. ; Mang, Thomas
JF  - International journal of peptide and protein research. 26 (1985), H. 2
Y1  - 1985
SN  - 0300-9769
SP  - 149
EP  - 157
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Steinberg, Thorsten
A1  - Sehr, Peter
A1  - Osen, Wolfram
T1  - Modification of HPV 16 E7 genes: correlation between the level of protein expression and CTL response after immunization of C57BL/6 mice / Steinberg, Thorsten ; Öhlschläger, Peter ; Sehr, Peter ; Osen, Wolfram ; Gissmann, Lutz
JF  - Vaccine. 23 (2005), H. 9
Y1  - 2005
SN  - 0264-410X
SP  - 1149
EP  - 1157
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J.
A1  - Meier, Rahel
A1  - Mojsen-Moeller, Jens
A1  - Seynnes, Olivier R.
T1  - Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task
JF  - Journal of Experimental Biology
Y1  - 2017
U6  - https://doi.org/10.1242/jeb.164111
SN  - 0022-0949
VL  - 220
IS  - 22
SP  - 4141
EP  - 4149
ER  - 
TY  - BOOK
A1  - Baüer, Herbert
A1  - Gilch, Heinz Gerhard
A1  - Rath, Walter
A1  - Schümann, Uwe
T1  - Moisture-curing polyurethane-based hot-melt compositions = Feuchthärtbare Heisschmelz-Zusammensetzungen auf Polyurethanbasis
Y1  - 1990
N1  - EP0386879 18.10.1990 Veröffentlichungstag im Patentblatt  ; Volltext recherchierbar über
PB  - Europäisches Patentamt
CY  - München
ER  - 
TY  - BOOK
A1  - Gilch, Heinz Gerhard
A1  - Rath, Walter
T1  - Moisture-curing, polyurethane hot-melt compositions = Feuchtigkeitshärtende Polyurethan-Schmelzklebstoff-Zusammensetzungen
Y1  - 1995
N1  - EP 0369607 30.03.1995 Veröffentlichungstag im Patentblatt ; Volltext recherchierbar über:
PB  - Europäisches Patentamt
CY  - München
ER  - 
TY  - CHAP
A1  - Medlin, L. K.
A1  - Barker, G. L. A.
A1  - Baumann, Marcus
A1  - Hayes, P. K.
T1  - Molecular biology and systematics
T2  - The Haptophyte Algae (Special volume / Systematics Association : 51)
Y1  - 1994
SN  - 0-19-857772-9
SP  - 393
EP  - 411
PB  - Clarendon Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Dutta, Suryendu
A1  - Hartkopf-Fröder, Christoph
A1  - Witte, Karin
A1  - Brocke, Rainer
A1  - Mann, Ulrich
T1  - Molecular characterization of fossil palynomorphs by transmission micro-FTIR spectroscopy: implications for hydrocarbon source evaluation
JF  - International journal of coal geology
Y1  - 2013
SN  - 1872-7840 (E-Journal); 0166-5162 (Print)
VL  - Vol. 115
SP  - 13
EP  - 23
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hentschke, Reinhard
A1  - Hager, Jonathan
A1  - Hojdis, Nils
T1  - Molecular Modeling Approach to the Prediction of Mechanical Properties of Silica-Reinforced Rubbers
JF  - Journal of Applied Polymer Science
N2  - Recently, we have suggested a nanomechanical model for dissipative loss in filled elastomer networks in the context of the Payne effect. The mechanism is based on a total interfiller particle force exhibiting an intermittent loop, due to the combination of short-range repulsion and dispersion forces with a long-range elastic attraction. The sum of these forces leads, under external strain, to a spontaneous instability of “bonds” between the aggregates in a filler network and attendant energy dissipation. Here, we use molecular dynamics simulations to obtain chemically realistic forces between surface modified silica particles. The latter are combined with the above model to estimate the loss modulus and the low strain storage modulus in elastomers containing the aforementioned filler-compatibilizer systems. The model is compared to experimental dynamic moduli of silica filled rubbers. We find good agreement between the model predictions and the experiments as function of the compatibilizer's molecular structure and its bulk concentration.
KW  - theory and modeling
KW  - supramolecular structures
KW  - rubber
KW  - mechanical properties
KW  - elastomers
Y1  - 2014
U6  - https://doi.org/10.1002/app.40806
SN  - 1097-4628
VL  - 131
IS  - 18
SP  - 1
EP  - 9
PB  - Wiley
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Lauth, Jakob
A1  - Hoelderich, W.
A1  - Wagenblast, G.
T1  - Molecular sieves containing azo dyes
JF  - Zeolites. 15 (1995), H. 2
Y1  - 1995
SN  - 0144-2449
SP  - 184
ER  - 
TY  - PAT
A1  - Lauth, Jakob
A1  - Hoelderich, Wolfgang
A1  - Wagenblast, Gerhard
T1  - Molecular sieves containing azo dyes : United States Patent ; patent number 5,573,585 ; date of patent: Nov. 12, 1996 / assignee: Wolfgang Hoelderich. Inventors: Guenter Lauth ; Wolfgang Hoelderich ; Gerhard Wagenblast ...
Y1  - 1996
N1  - Barcode: US005573585A ; Volltext über Datenbank: http://www.google.com/patents
PB  - [United States Trademark and Patent Office]
CY  - [Alexandria, VA]
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Hoelderich, Wolfgang
A1  - Wagenblast, Gerhard
T1  - Molecular sieves containing azo dyes ; Internationale [Pantent]anmeldung WO93/17965 ; Veröffentlichungsdatum: 16.09.1993  / Anmelder: BASF AG
Y1  - 1993
N1  - Volltext über Datenbank http://depatisnet.dpma.de/
PB  - Weltorganisation für geistiges Eigentum, Internat. Büro
CY  - [Genf]
ER  - 
TY  - JOUR
A1  - Meyer, Jan
A1  - Hentschke, Reinhard
A1  - Hager, Jonathan
A1  - Hojdis, Nils
A1  - Karimi-Varzaneh, Hossein Ali
T1  - Molecular Simulation of Viscous Dissipation due to Cyclic Deformation of a Silica–Silica Contact in Filled Rubber
JF  - Macromolecules
Y1  - 2017
U6  - https://doi.org/10.1021/acs.macromol.7b00947
SN  - 1520-5835
VL  - 50
IS  - 17
SP  - 6679
EP  - 6689
ER  - 
TY  - PAT
A1  - Lauth, Jakob
A1  - Hölderich, Wolfgang
A1  - Wagenblast, Gerhard
A1  - Schefczik, Ernst
T1  - Molekularsiebe, enthaltend Farbstoffe auf Basis von Indigo : Offenlegungsschrift DE4207339A1 ; Veröffentlichungstag im Patentblatt: 16.09.1993 / Anmelder: BASF AG, 67063 Ludwigshafen
Y1  - 1993
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Hoelderich, Wolfgang
A1  - Wagenblast, Gerhard
T1  - Molekularsiebe, enthaltend Farbstoffe auf Basis von Indigo = Molecular sieves containing indigo-based dyes ; Europäische Patenanmeldung EP0630353A1 ; Veröffentlichungsdatum 28.12.1994 / Anmelder: BASF AG
Y1  - 1994
N1  - Internationale Anmeldung veröffentlicht durch die Weltorganisation für geistiges Eigentum unter der Nummer WO 93/17966
PB  - Europäisches Patentamt
CY  - [München u.a.]
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Hoelderich, Wolfgang
A1  - Wagenblast, Gerhard
T1  - Molekularsiebe, enthaltend Farbstoffe auf Basis von Indigo = Molecular sieves containing indigo-based dyes ; Internationale [Pantent]anmeldung WO 93/17966 ; Veröffentlichungsdatum 16.09.1993 / Anmelder: BASF AG
Y1  - 1993
N1  - Volltext über Datenbank http://depatisnet.dpma.de/
PB  - Weltorganisation für geistiges Eigentum, Internat. Büro
CY  - [Genf]
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Haulena, Friedhelm
T1  - Monodisperse latex particles with functional groups
JF  - Modification of polymers : 4th Dresden Polymer Discussion ; September 22 to 25, 1992 at Gaussig / Dresden University of Technology, Department of Macromolecular Chemistry and Textile Chemistry; Institute of Polymer Technology Dresden. [Organizers: Claudia Kummerlöwe ...]
Y1  - 1992
N1  - Dresdner Polymer Discussion <4, 1992, Gaußig>
SP  - 68
EP  - 88
PB  - Univ.
CY  - Dresden
ER  - 
TY  - PAT
A1  - Lauth, Jakob
A1  - Trübenbach, Peter
A1  - Hagemeyer, Alfred
T1  - Monomodal and polymodal catalyst supports and catalysts having narrow pore size distributions and their production : United States Patent ; patent number 5,935,898 ; date of patent: Aug. 10, 1999 / assignee: BASF Aktiengesellschaft. Inventors: Peter Trubenbach ; Alfred Hagemeyer ; Gunter Lauth ...
Y1  - 1999
N1  - Barcode: US005935898A ; Volltext über Datenbank: http://www.google.com/patents ; Falsche Namensansetzung in Datenbank: Gunter ...
PB  - [United States Patent and Trademark Office]
CY  - [Alexandria, VA]
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Trübenbach, Peter
A1  - Hagemeyer, Alfred
T1  - Monomodale und polymodale Katalysatorträger und Katalysatoren mit engen Porengrössenverteilungen und deren Herstellverfahren : Europäische Patentschrift EP0764467B1 ; EP-Patenterteilungsdatum: 05.02.2003 / Anmelder: BASF AG, 67063 Ludwigshafen. Erfinder: Peter Trübenbach ; Alfred Hagemeyer ; Günter Lauth ...
Y1  - 2003
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Europäisches Patentamt
CY  - [München u.a.]
ER  - 
TY  - PAT
A1  - Lauth, Jakob
A1  - Trübenbach, Peter
A1  - Hagemeyer, Alfred
A1  - Dingerdissen, Uwe [u.a.]
T1  - Monomodale und polymodale Katalysatorträger und Katalysatoren mit engen Porengrößenverteilungen und deren Herstellverfahren : Offenlegungschrift DE19533486A1 ; Veröffentlichungstag im Patentblatt: 13.03.1997 / Anmelder: BASF AG, 67063 Ludwigshafen. Erfinder: Peter Trübenbach ; Alfred Hagemeyer ; Günter Lauth ...
Y1  - 1997
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Trübenbach, Peter
A1  - Hagemeyer, Alfred
T1  - Monomodale und polymodale Katalysatorträger und Katalysatoren mit engen Porengrößenverteilungen und deren Herstellverfahren = Monomodal and polymodal catalyst supports and catalysts with a narrow pore size distribution and method for producing the same ; Europäische Patentschrift EP0761307B1 ; Veröffentlichungsdatum 05.02.2003  / Anmelder: BASF Aktiengesellschaft. Erfinder: Peter Trübenbach ; Alfred Hagemeyer ; Günther Lauth ...
Y1  - 2003
N1  - Volltext über Datenbank http://publikationen.dpma.de/ ; Falsche Namenansersetzung in Datenbank: Günther
PB  - Europäisches Patentamt
CY  - [München u.a.]
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W.K.
T1  - Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent
JF  - Journal of Pharmaceutical and Biomedical Analysis
N2  - NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products.
KW  - NMR spectroscopy
KW  - Inorganic ions
KW  - Heparin
KW  - Standardization
Y1  - 2022
SN  - 0731-7085
U6  - https://doi.org/10.1016/j.jpba.2021.114530
VL  - 209
IS  - Article number: 114530
PB  - Elsevier
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Lang, E. W.
T1  - Multinuclear Spin-Lattice Relaxation Time Studies of Supercooled Aqueous LiCl-Solutions / E .W. Lang, F. X. Prielmeier
JF  - Berichte der Bunsen-Gesellschaft für Physikalische Chemie. 92 (1988)
Y1  - 1988
SN  - 0005-9021
SP  - 717
ER  - 
TY  - JOUR
A1  - Svaneborg, Carsten
A1  - Karimi-Varzaneh, Hossein Ali
A1  - Hojdis, Nils
A1  - Fleck, Franz
A1  - Everaers, Ralf
T1  - Multiscale approach to equilibrating model polymer melts
JF  - Physical Review E
N2  - We present an effective and simple multiscale method for equilibrating Kremer Grest model polymer melts of varying stiffness. In our approach, we progressively equilibrate the melt structure above the tube scale, inside the tube and finally at the monomeric scale. We make use of models designed to be computationally effective at each scale. Density fluctuations in the melt structure above the tube scale are minimized through a Monte Carlo simulated annealing of a lattice polymer model. Subsequently the melt structure below the tube scale is equilibrated via the Rouse dynamics of a force-capped Kremer-Grest model that allows chains to partially interpenetrate. Finally the Kremer-Grest force field is introduced to freeze the topological state and enforce correct monomer packing. We generate 15 melts of 500 chains of 10.000 beads for varying chain stiffness as well as a number of melts with 1.000 chains of 15.000 monomers. To validate the equilibration process we study the time evolution of bulk, collective, and single-chain observables at the monomeric, mesoscopic, and macroscopic length scales. Extension of the present method to longer, branched, or polydisperse chains, and/or larger system sizes is straightforward.
Y1  - 2016
U6  - https://doi.org/10.1103/PhysRevE.94.032502
SN  - 2470-0053
VL  - 94
IS  - 032502
PB  - AIP Publishing
CY  - Melville, NY
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Gronsfeld, A.
A1  - Schütz-Lembach, G.
T1  - Nachdenklichkeit über Nachhaltigkeit : wie uns ein neues Wort alte Probleme neu entdecken läßt
JF  - Wechselwirkung : Wissenschaft & vernetztes Denken
Y1  - 1997
SN  - 0172-1623
VL  - 19
IS  - 87
SP  - 6
EP  - 11
ER  - 
TY  - BOOK
A1  - Selmer, Thorsten
T1  - Nachweis einer neuartigen posttranslationalen Modifikation in Sulfatasen und ihr Fehlen in Enzymen aus Patienten mit multipler Sulfatase-Defizienz
Y1  - 1996
N1  - Zugl.: Göttingen, Univ., Diss., 1996
PB  - Cuvillier
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Druckenmüller, Katharina
A1  - Günther, Klaus
A1  - Elbers, Gereon
T1  - Near-infrared spectroscopy (NIRS) as a tool to monitor exhaust air from poultry operations
JF  - Science of the Total Environment
N2  - Intensive poultry operation systems emit a considerable volume of inorganic and organic matter in the surrounding environment. Monitoring cleaning properties of exhaust air cleaning systems and to detect small but significant changes in emission characteristics during a fattening cycle is important for both emission and fattening process control. In the present study, we evaluated the potential of near-infrared spectroscopy (NIRS) combined with chemometric techniques as a monitoring tool of exhaust air from poultry operation systems. To generate a high-quality data set for evaluation, the exhaust air of two poultry houses was sampled by applying state-of-the-art filter sampling protocols. The two stables were identical except for one crucial difference, the presence or absence of an exhaust air cleaning system. In total, twenty-one exhaust air samples were collected at the two sites to monitor spectral differences caused by the cleaning device, and to follow changes in exhaust air characteristics during a fattening period. The total dust load was analyzed by gravimetric determination and included as a response variable in multivariate data analysis. The filter samples were directly measured with NIR spectroscopy. Principal component analysis (PCA), linear discriminant analysis (LDA), and factor analysis (FA) were effective in classifying the NIR exhaust air spectra according to fattening day and origin. The results indicate that the dust load and the composition of exhaust air (inorganic or organic matter) substantially influence the NIR spectral patterns. In conclusion, NIR spectroscopy as a tool is a promising and very rapid way to detect differences between exhaust air samples based on still not clearly defined circumstances triggered during a fattening period and the availability of an exhaust air cleaning system.
Y1  - 2018
U6  - https://doi.org/10.1016/j.scitotenv.2018.02.072
SN  - 0048-9697
VL  - 630
SP  - 536
EP  - 543
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Wieland, Susanne
A1  - Engelskirchen, Julia
A1  - Merkel, Marion
A1  - Maurer, Karl-Heinz
A1  - Bessler, Cornelius
T1  - Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease [Offenlegungsschrift]
T1  - Novel alkaline protease from Bacillus Gibsonii and washing and cleaning agents containing said novel alkaline protease [Europäische Patentanmeldung / US Patentanmeldung / Internationale Patentanmeldung]
Y1  - 2008
SP  - 1
EP  - 51
PB  - Deutsches Patentamt / Europäisches Patentamt / WIPO
CY  - München / Den Hague / Genf
ER  - 
TY  - PAT
A1  - Merkel, Marion
A1  - Weber, Angrit
A1  - Siegert, Petra
A1  - Wieland, Susanne
A1  - Maurer, Karl-Heinz
A1  - Bessler, Cornelius
T1  - Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease [Offenlegungsschrift]
T1  - Novel alkaline protease from Bacillus Gibsonii and washing and cleaning agents containing said novel alkaline protease [Internationale Patentanmeldung]
Y1  - 2007
SP  - 1
EP  - 46
PB  - Deutsches Patent- und Markenamt / WIPO
CY  - München / Genf
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Jelinek, N.
A1  - Schmidt, S.
A1  - Hilbert, U.
T1  - Neue Bioreaktoren zur Kultivierung hämatopoetischer Zellen / Jelinek, N. ; Schmidt, S. ; Hilbert, U. ; Thoma, S. ; Biselli, M. ; Wandrey, C.
JF  - Chemie Ingenieur Technik. 73 (2001), H. 7
Y1  - 2001
SN  - 0009-286X
SP  - 894
EP  - 898
ER  - 
TY  - BOOK
A1  - Berndt, Heinz
T1  - Neue Kondensations-Methoden zur Synthese definierter Peptid-Derivate
Y1  - 2014
N1  - Aachen, Techn. Hochsch., Habil.-Schr., 1982
CY  - Aachen
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Merkel, Marion
A1  - Kluin, Cornelia
A1  - Maurer, Karl-Heinz
A1  - O'Connell, Timothy
A1  - Wieland, Susanne
A1  - Hellmuth, Hendrik
T1  - Neue Proteasen und diese enthaltende Mittel [Offenlegungsschrift]
T1  - Novel proteases and compositions comprising them [Europäische Patentanmeldung / Internationale Patentanmeldung]
Y1  - 2011
SP  - 1
EP  - 21
PB  - Deutsches Patent- und Markenamt / Europäisches Patentamt / WIPO
CY  - München / Den Hague / Genf
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Mussmann, Nina
A1  - O'Connell, Timothy
A1  - Maurer, Karl-Heinz
T1  - Neue Proteasen und Mittel enthaltend diese Proteasen [Offenlegungsschrift]
T1  - Novel proteases and means containing said proteases [Internationale Patentanmeldung]
Y1  - 2010
SP  - 1
EP  - 30
PB  - Deutsches Patent- und Markenamt / WIPO
CY  - München / Genf
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Baumstark, Rebecca
A1  - Kluin, Cornelia
A1  - O'Connell, Timothy
A1  - Maurer, Karl-Heinz
A1  - Hellmuth, Hendrik
T1  - Neue Proteasen und Mittel enthaltend diese Proteasen [Offenlegungsschrift]
Y1  - 2010
SP  - 1
EP  - 30
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Spitz, Astrid
A1  - Maurer, Karl-Heinz
T1  - Neue Proteasen und Mittel enthaltend diese Proteasen [Offenlegungsschrift]
T1  - Novel proteases and compositions comprising these proteases [Internationale Patentanmeldung]
Y1  - 2010
SP  - 1
EP  - 31
PB  - Deutsches Patentamt / WIPO
CY  - München / Genf
ER  - 
TY  - PAT
A1  - Jeromin, Günter Erich
A1  - Mang, Thomas
T1  - Neue Technik mit magnetisierbaren Materialien : Offenlegungsschrift DE102004005201A1 ; Offenlegungstag: 11.08.2005
Y1  - 2005
N1  - Volltext über Datenbank DEPATISnet
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - PAT
A1  - Jeromin, Günter Erich
A1  - Schwarzer, Klemens
T1  - Neuer Wärmeträger für Solaranlagen : Offenlegungsschrift : DE 102007016738 A1 ; Offenlegungstag: 09.10.2008
Y1  - 2008
N1  - Volltext über Datenbank DEPATISnet: http://depatisnet.dpma.de/DepatisNet/depatisnet?action=pdf&docid=DE102007016738A1
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - GEN
A1  - Roth, J.
A1  - Tippkötter, Nils
T1  - New Approach for Enzymatic Hydrolysis of Lignocellulose with Selective Diffusion Separation of the Monosaccharide Products
T2  - Chemie Ingenieur Technik
N2  - Enzymatic hydrolysis of lignocellulosic material plays an important role in the classical biorefinery approach. Apart from the pretreatment of the raw material, hydrolysis is the basis for the conversion of the cellulose and hemicellulose fraction into fermentable sugars. After hydrolysis, usually a solid-liquid separation takes place, in order to separate the residual plant material from the sugar-rich fraction, which can be subsequently used in a fermentation step. In order to factor out the separation step, the usage of in alginate immobilized crude cellulose fiber beads (CFBs) were evaluated. Pretreated cellulose fibers are incorporated in an alginate matrix together with the relevant enzymes. In doing so, sugars diffuse trough the alginate matrix, allowing a simplified delivery into the surrounding fluid. This again reduces product inhibition of the glucose on the enzyme catalysts. By means of standardized bead production the hydrolysis in lab scale was possible. First results show that liberation of glucose and xylose is possible, allowing a maximum total sugar yield of 75 %.
Y1  - 2016
U6  - https://doi.org/10.1002/cite.201650301
SN  - 0009-286X
SN  - 1522-2640 (eISSN)
N1  - ProcessNet-Jahrestagung 2016 und 32. DECHEMA-Jahrestagung der Biotechnologen 2016, 12. - 15. September 2016, Eurogress Aachen
VL  - 88
IS  - 9
SP  - 1237
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Pierik, Antonio J.
A1  - Heider, Johann
T1  - New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria
JF  - Biological Chemistry. 386 (2005), H. 10
Y1  - 2005
SN  - 1431-6730
SP  - 981
EP  - 988
ER  - 
TY  - JOUR
A1  - Oehlenschläger, Katharina
A1  - Volkmar, Marianne
A1  - Stiefelmaier, Judith
A1  - Langsdorf, Alexander
A1  - Holtmann, Dirk
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - New insights into the influence of pre-culture on robust solvent production of C. acetobutylicum
JF  - Applied Microbiology and Biotechnology
N2  - Clostridia are known for their solvent production, especially the production of butanol. Concerning the projected depletion of fossil fuels, this is of great interest. The cultivation of clostridia is known to be challenging, and it is difficult to achieve reproducible results and robust processes. However, existing publications usually concentrate on the cultivation conditions of the main culture. In this paper, the influence of cryo-conservation and pre-culture on growth and solvent production in the resulting main cultivation are examined. A protocol was developed that leads to reproducible cultivations of Clostridium acetobutylicum. Detailed investigation of the cell conservation in cryo-cultures ensured reliable cell growth in the pre-culture. Moreover, a reason for the acid crash in the main culture was found, based on the cultivation conditions of the pre-culture. The critical parameter to avoid the acid crash and accomplish the shift to the solventogenesis of clostridia is the metabolic phase in which the cells of the pre-culture were at the time of inoculation of the main culture; this depends on the cultivation time of the pre-culture. Using cells from the exponential growth phase to inoculate the main culture leads to an acid crash. To achieve the solventogenic phase with butanol production, the inoculum should consist of older cells which are in the stationary growth phase. Considering these parameters, which affect the entire cultivation process, reproducible results and reliable solvent production are ensured.
KW  - Pre-culture
KW  - Metabolic shift
KW  - Acid crash
KW  - C. acetobutylicum
KW  - ABE
KW  - Butanol
Y1  - 2024
U6  - https://doi.org/10.1007/s00253-023-12981-8
SN  - 1432-0614
VL  - 108
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Kratz, J. V.
A1  - Gober, M. K.
A1  - Zimmermann, H. P.
T1  - New nuclide 263 105 / J.V. Kratz, M.K. Gober, H.P. Zimmermann, M. Schädel, W. Brüchle, E. Schimpf, K.E. Gregorich, A. Türler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M.J. Nurmia, D.C. Hoffman, H. Gäggeler, D. Jost, U.W. Scherer, A. Weber
JF  - Physical Review C . 45 (1992)
Y1  - 1992
SP  - 1064
EP  - 1069
ER  - 
TY  - JOUR
A1  - Thiel, Alexander
A1  - Tippkötter, Nils
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - New zeolite adsorbents for downstream processing of polyphenols from renewable resources
JF  - Engineering in Life Sciences
N2  - Commercial materials with polyvinylpolypyrrolidone and polymeric amberlites (XAD7HP, XAD16) are commonly used for the adsorptive downstream processing of polyphenols from renewable resources. In this study, beta-zeolite-based adsorbent systems were examined, and their properties were compared to organic resins. Batch adsorption experiments were conducted with synthetic solutions of major polyphenols. Adsorption isotherms and desorption characteristics of individual adsorbent were determined based on these results. Maximum adsorption capacities were calculated using the Langmuir model. For example, the zeolites had capacities up to 203.2 mg/g for ferulic acid. To extend these results to a complex system, additional experiments were performed on rapeseed meal and wheat seed extracts as representative renewable resources. HPLC analysis showed that with 7.5% w/v, which is regarded as the optimum amount of zeolites, zeolites A and B could bind 100% of the major polyphenols as well as release polyphenols at high yields. Additionally, regeneration experiments were performed with isopropyl alcohol at 99°C to evaluate how zeolites regenerate under mild conditions. The results showed only a negligible loss of adsorption capacity and no loss of desorption capacity. In summary, it was concluded that beta-zeolites were promising adsorbents for developing new processes to isolate polyphenols from renewable resources.
Y1  - 2013
U6  - https://doi.org/10.1002/elsc.201200188
VL  - 13
IS  - 3
SP  - 239
EP  - 246
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - PAT
A1  - Jeromin, Günter Erich
A1  - Seubert, Bernhard
A1  - Beilharz, Helmut
A1  - Fickert, Werner [u.a.]
T1  - Niedermolekulare Alkalihuminate : Verfahren zu ihrer Herstellung und Verwendung ; Offenlegungsschrift DE3707909A1 ; Offenlegungstag: 22.09.1988 / Anmelder: Rütgerswerke AG, 6000 Frankfurt. Erfinder: Bernhard Seubert ; Helmut Beilharz ; Werner Fickert ; Günter Jeromin ...
Y1  - 1988
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - PAT
A1  - Jeromin, Günter Erich
A1  - Seubert, Bernhard
A1  - Beilharz, Helmut
A1  - Fickert, Werner [u.a.]
T1  - Niedermolekulare Alkalihuminate : Verfahren zur ihrer Herstellung und Verwendung ; Europäische Patentschrift EP0281679B1 ; Veröffentlichungstag im Patentblatt: 01.08.1991 / Anmelder: Rütgerswerke AG, 6000 Frankfurt. Erfinder: Bernhard Seubert ; Helmut Beilharz ; Günter Jeromin ; Werner Fickert ...
Y1  - 1991
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - JOUR
A1  - Elbers, Gereon
A1  - Gäb, Martina
A1  - Hoffmann, Katharina
A1  - Lobe, Melanie
T1  - NIR-spectroscopic investigation of foliage of ozone-stressed Fagus sylvatica trees / Gäb, Martina ; Hoffmann, Katharina ; Lobe, Melanie ; Metzger, Rut ; Ooyen, Sven van ; Elbers, Gereon ; Köllner, Barbara
JF  - Journal of Forest Research. 11 (2006), H. 2
Y1  - 2006
SN  - 1341-6979
SP  - 69
EP  - 75
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Roikaew, W.
A1  - Ulber, Roland
T1  - Nitrate removal from whey concentrate with biotechnological regeneration of the waste water
JF  - European dairy magazine : EDM
Y1  - 2008
SN  - 0936-6318
IS  - 1
SP  - 30
EP  - 32
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Roikaew, N.
A1  - Ulber, Roland
T1  - Nitratentfernung aus Molkekonzentrat mit biotechnologischer Regeneration der Abwässer
JF  - Deutsche Milchwirtschaft
Y1  - 2007
SN  - 0012-0480
VL  - 58
IS  - 15
SP  - 540
EP  - 542
ER  - 
TY  - JOUR
A1  - Ulber, Roland
A1  - Tippkötter, Nils
T1  - Nitratfreie Molke
JF  - Rundschau für Fleischhygiene und Lebensmittelüberwachung
Y1  - 2009
IS  - 4
SP  - 150
EP  - 152
ER  - 
TY  - JOUR
A1  - Braband, Henrik
A1  - Paulßen, Elisabeth
A1  - Abram, Ulrich
T1  - Nitridorhenium(V) Complexes with 1,3-Dialkyl-4,5-dimethylimidazole-2-ylidenes
JF  - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry
Y1  - 2006
U6  - https://doi.org/10.1002/zaac.200600002
SN  - 1521-3749
VL  - 632
IS  - 6
SP  - 1051
EP  - 1056
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Semeneh, M.
A1  - Dehairs, F.
A1  - Elskens, M.
T1  - Nitrogen uptake regime and phytoplankton community structure in the Southern Ocean / Semeneh, M. ; Dehairs, F. ; Elskens, M. ; Baumann, M.E.M. ; Kopczynska, E.E. ; Lancelot, C. ; Goeyens, L.
JF  - Journal of Marine Systems. 17 (1998), H. 1-4
Y1  - 1998
SN  - 0924-7963
SP  - 159
EP  - 177
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Greger, M.
A1  - Ihme, B.
T1  - Nonequilibrium phase transitions with hysteresis in solid catalysts : the system copper-oxygen-propene / M. Greger ; B. Ihme ; M. Kotter ...
JF  - Berichte der Bunsen-Gesellschaft für Physikalische Chemie. 88 (1984)
Y1  - 1984
SN  - 0005-9021
SP  - 427
EP  - 433
ER  - 
TY  - JOUR
A1  - Lawson, Nathan D.
A1  - Scheer, Nico
A1  - Pham, Van N.
A1  - Kim, Ceol-Hee
A1  - Chitnis, Ajay B.
A1  - Campos-Ortega, José A.
A1  - Weinstein, Brant M.
T1  - Notch signaling is required for arterial-venous differentiation during embryonic vascular development
JF  - Development
Y1  - 2001
SN  - 1477-9129
VL  - 128
IS  - 19
SP  - 3675
EP  - 3683
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W.K.
T1  - Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard
JF  - Talanta
N2  - Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated.

In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).
KW  - qNMR
KW  - Deuterium NMR
KW  - Deuterated solvents
KW  - Standardization
Y1  - 2021
SN  - 0039-9140
U6  - https://doi.org/10.1016/j.talanta.2020.121504
VL  - 222
IS  - Article number: 121504
PB  - Elsevier
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Jelinek, N.
A1  - Schmidt, S.
A1  - Hilbert, U.
T1  - Novel bioreactors for the ex vivo cultivation of hematopoietic cells / Jelinek, N. ; Schmidt, S. ; Hilbert, U. ; Thoma, S. ; Biselli, M. ; Wandrey, C.
JF  - Engineering in Life Sciences. 2 (2002), H. 1
Y1  - 2002
SN  - 1618-0240
SP  - 15
EP  - 18
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Jennemann, Richard
A1  - Bauer, Bernhard L.
A1  - Bertalanffy, Helmut
T1  - Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus / Jennemann, Richard ; Bauer, Bernhard, L. ; Bertalanffy, Helmut ; Geyer, Rudolf ; Gschwind, Ruth, M. ; Selmer, Thorsten ; Wiegandt, Herbert
JF  - European Journal of Biochemistry. 259 (1999), H. 1-2
Y1  - 1999
SN  - 0014-2956
SP  - 331
EP  - 338
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W.K.
T1  - Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material
JF  - Journal of Pharmaceutical and Biomedical Analysis
N2  - Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed. For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard. The method was successfully validated for its accuracy, reproducibility, and precision. The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %. The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride. A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available. A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs. NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
KW  - NMR spectroscopy
KW  - Heparin
KW  - Crude heparin
KW  - USP
KW  - Ions
Y1  - 2022
U6  - https://doi.org/10.1016/j.jpba.2022.114915
SN  - 0731-7085
VL  - 219
IS  - Article number: 114915
PB  - Elsevier
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Stanley, Lesley A.
A1  - Horsburgh, Brian C.
A1  - Ross, Jillian
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Nuclear Receptors which play a pivotal role in drug disposition and chemical toxicity
JF  - Drug Metabolism Reviews
Y1  - 2006
U6  - https://doi.org/10.1080/03602530600786232
SN  - 1097-9883
VL  - 38
IS  - 3
SP  - 515
EP  - 597
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Groebel, Simone
A1  - Krumbe, Christoph
A1  - Wagner, Torsten
A1  - Selmer, Thorsten
A1  - Yoshinobu, Tatsuo
A1  - Baumann, Marcus
A1  - Schöning, Michael Josef
T1  - Nutrient concentration-sensitive microorganism-based biosensor
JF  - Physica Status Solidi (a)
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100801
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 900
EP  - 904
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - GEN
A1  - Tippkötter, Nils
A1  - Möhring, S.
T1  - Nutzung von Fäulepilzen für die selektive Gewinnung von Cellulose und Lignin aus nicht vorbehandelter lignocellulosehaltiger Biomasse
T2  - Chemie Ingenieur Technik
N2  - Einige Arten der Braun- und Weißfäulepilze sind in der Lage, selektiv entweder Lignin oder Cellulose im Holz abzubauen. Diese Pilze können für eine energiesparende Vorbehandlung lignocellulosehaltiger Biomasse für Bioraffinerien genutzt werden, ohne auf technisch aufwändige Aufschlussapparate zurückgreifen zu müssen. Weißfäulepilze bauen bevorzugt Lignin ab, wodurch die verbleibende Cellulose leichter für enzymatische Hydrolysen in das Monosaccharid Glucose zugänglich wird. Braunfäulepilze bauen dagegen Cellulose und Hemicellulose ab. Die Auswirkungen der Behandlung von Weizenstroh mit verschiedenen Pilzarten werden zurzeit untersucht. Dabei werden die Veränderung der enzymatischen Hydrolysierbarkeit des Substrats sowie die gebildeten Ligninderivate bestimmt. Detaillierte Betrachtungen der Biomasseveränderung werden mithilfe spezifischer Färbemethoden durchgeführt, durch die morphologische Veränderungen der Pflanzengewebe in der 3D-Lichtmikroskopie dargestellt werden können.
Y1  - 2014
U6  - https://doi.org/10.1002/cite.201450353
SN  - 0009-286X
SN  - 1522-2640 (eISSN)
N1  - ProcessNet-Jahrestagung 2014 und 31. DECHEMA-Jahrestagung der Biotechnologen, 30. September - 2. Oktober 2014, Eurogress Aachen
N1  - Diese Arbeit wird durch das Bundesministerium für Ernährung und Landwirtschaft über die FNR e.V. unter dem Projektnamen „Lokale Vorbehandlung nachwachsender Rohstoffe für Bioraffinerien“ gefördert (FKZ 22028411)
VL  - 86
IS  - 9
SP  - 1385
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - GEN
A1  - Wiesen, S.
A1  - Tippkötter, Nils
A1  - Muffler, K.
A1  - Sohling, U.
A1  - Ruf, F.
A1  - Ulber, Roland
T1  - Nutzung von Rohglycerin: Rohglycerin-Aufarbeitung, Herstellung von 1, 3-Propandiol und Rückgewinnung von Fettsäuren
T2  - Chemie Ingenieur Technik
N2  - Die fermentative Verwertung von Rohglycerin setzt je nach Herstellungsmethode und Produktionsorganismus eine Vorbehandlung des Glycerins zur Entfernung von Produktinhibitoren voraus. Durch den Einsatz von Hydrotalcit-Adsorbern können die im Rohglycerin enthaltenen Fettsäuren entfernt werden. Durch diese einfache Aufarbeitungsmethode ist ein mit reinem Glycerin vergleichbarer Umsatz von stark mit Fettsäuren verunreinigtem Rohglycerin zu 1,3-Propandiol (PDO) möglich. Die durch den Hydrotalcit gebundenen Fettsäuren lassen sich mit einem Ethanol-Wasser-Gemisch eluieren. Somit kann der Adsorber regeneriert und die Fettsäuren wieder der Wertschöpfungskette zugeführt werden. Im Fed-Batch-Experiment kann mit C. diolis eine PDO-Konzentration von über 50 g L⁻¹ unter Verwendung des aufgereinigten Rohglycerins erzielt werden. In der industriellen Produktion wird PDO momentan destillativ aufgearbeitet. Ein adsorptives Aufarbeitungsverfahren kann den Energiebedarf des Herstellungsprozesses drastisch senken. Auf der Suche nach einem geeigneten Material wurde ein Adsorberscreening in Bezug auf die Bindungseigenschaften durchgeführt. Mit einem b-Zeolith der Firma Süd ChemieAG konnte bisher die höchste Beladung im Modellsystem von 120 mg PDO/gAdsorber erreicht werden.
Y1  - 2012
U6  - https://doi.org/10.1002/cite.201250265
SN  - 0009-286X
SN  - 1522-2640 (eISSN)
N1  - ProcessNet-Jahrestagung 2012 und 30. DECHEMA-Jahrestagung der Biotechnologen, 10. – 13. September 2012, Karlsruhe
VL  - 84
IS  - 8
SP  - 1296
PB  - Wiley-VCH
CY  - Weinheim
ER  -