TY - JOUR A1 - Scheer, Nico A1 - Campos-Ortega, José A. T1 - Use of the Gal4-UAS technique for targeted gene expression in the zebrafish JF - Mechanism of Development Y1 - 1999 U6 - https://doi.org/10.1016/S0925-4773(98)00209-3 SN - 0925-4773 VL - 80 IS - 2 SP - 153 EP - 158 ER - TY - JOUR A1 - Scheer, Nico A1 - Wilson, Ian D. T1 - A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity JF - Drug Discovery Today N2 - Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug–drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives. Y1 - 2016 U6 - https://doi.org/10.1016/j.drudis.2015.09.002 SN - 1359-6446 VL - 21 IS - 2 SP - 250 EP - 263 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Scheer, Nico A1 - Wolf, C. Roland T1 - Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications JF - Xenobiotica N2 - 1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug–drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug–drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed. KW - transporters KW - human metabolites KW - drug metabolising enzymes KW - drug–drug interactions KW - bioavailability Y1 - 2014 U6 - https://doi.org/10.3109/00498254.2013.815831 SN - 1366-5928 VL - 44 IS - 2 SP - 96 EP - 108 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Scheer, Nico A1 - Wolf, C. Roland T1 - Xenobiotic receptor humanized mice and their utility JF - Drug Metabolism Reviews Y1 - 2013 U6 - https://doi.org/10.3109/03602532.2012.738687 SN - 1097-9883 IS - 1 SP - 110 EP - 121 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Henderson, Colin J. A1 - Scheer, Nico A1 - Wolf, C. Roland T1 - Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man JF - Expert Review of Clinical Pharmacology Y1 - 2009 U6 - https://doi.org/10.1586/17512433.2.2.105 SN - 1751-2441 VL - 2 IS - 2 SP - 105 EP - 109 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Stanley, Lesley A. A1 - Horsburgh, Brian C. A1 - Ross, Jillian A1 - Scheer, Nico A1 - Wolf, C. Roland T1 - Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior JF - Drug Metabolism Reviews Y1 - 2009 U6 - https://doi.org/10.1080/03602530802605040 SN - 1097-9883 VL - 41 IS - 1 SP - 27 EP - 65 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Stanley, Lesley A. A1 - Horsburgh, Brian C. A1 - Ross, Jillian A1 - Scheer, Nico A1 - Wolf, C. Roland T1 - Nuclear Receptors which play a pivotal role in drug disposition and chemical toxicity JF - Drug Metabolism Reviews Y1 - 2006 U6 - https://doi.org/10.1080/03602530600786232 SN - 1097-9883 VL - 38 IS - 3 SP - 515 EP - 597 ER - TY - CHAP A1 - Samuelsson, K. A1 - Scheer, Nico A1 - Wilson, I. A1 - Wolf, C.R. A1 - Henderson, C.J. ED - Chackalamannil, Samuel T1 - Genetically Humanized Animal Models T2 - Comprehensive Medicinal Chemistry III. 3rd Edition N2 - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development. KW - Chimeric liver-humanized mice KW - Drug distribution KW - Drug metabolism KW - Toxicology KW - Knockout mice Y1 - 2017 SN - 978-0-12-803201-5 U6 - https://doi.org/10.1016/B978-0-12-409547-2.12376-5 SP - 130 EP - 149 PB - Elsevier CY - Saint Louis ER - TY - CHAP A1 - Scheer, Nico A1 - Chu, Xiaoyan A1 - Salphati, Laurent A1 - Zamek-Gliszczynski, Maciej J. ED - Nicholls, Glynis T1 - Knockout and humanized animal models to study membrane transporters in drug development T2 - Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development Y1 - 2016 SN - 978-1-78262-379-3 U6 - https://doi.org/10.1039/9781782623793-00298 SP - 298 EP - 332 PB - Royal Society of Chemistry CY - Cambridge ER - TY - CHAP A1 - Braun, Sebastian A1 - Cheng, Chi-Tsun A1 - Lai, Chow Yin A1 - Wollert, Jörg T1 - Microservice Architecture for Automation - Realization by the example of a model-factory’s manufacturing execution system T2 - Proceedings of the 23rd World Multi-Conference on Systemics, Cybernetics and Informatics: WMSCI 2019 Y1 - 2019 SP - 33 EP - 37 ER - TY - JOUR A1 - Dadfar, Dryed Mohammadali A1 - Camozzi, Denise A1 - Darguzyte, Milita A1 - Roemhild, Karolin A1 - Varvarà, Paola A1 - Metselaar, Josbert A1 - Banala, Srinivas A1 - Straub, Marcel A1 - Güver, Nihan A1 - Engelmann, Ulrich M. A1 - Slabu, Ioana A1 - Buhl, Miriam A1 - Leusen, Jan van A1 - Kögerler, Paul A1 - Hermanns-Sachweh, Benita A1 - Schulz, Volkmar A1 - Kiessling, Fabian A1 - Lammers, Twan T1 - Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance JF - Journal of Nanobiotechnology N2 - Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications. Y1 - 2020 U6 - https://doi.org/10.1186/s12951-020-0580-1 SN - 1477-3155 VL - 18 IS - Article number 22 SP - 1 EP - 13 PB - Nature Portfolio ER - TY - CHAP A1 - Horikawa, Atsushi A1 - Okada, Kunio A1 - Uto, Takahiro A1 - Uchiyama, Yuta A1 - Wirsum, Manfred A1 - Funke, Harald A1 - Kusterer, Karsten T1 - Application of Low NOx Micro-mix Hydrogen Combustion to 2MW Class Industrial Gas Turbine Combustor T2 - Proceedings of International Gas Turbine Congress 2019 Tokyo, November 17-22, 2019, Tokyo, Japan Y1 - 2019 SN - 978-4-89111-010-9 N1 - IGTC-2019-129 SP - 1 EP - 6 ER - TY - CHAP A1 - Matcha, Heike A1 - Karzel, Rüdiger A1 - Quasten, Gero T1 - Architectural Design with Parametric Modeling & Customized Mass Production: Explorations and Case Studies in Architectural Design and Production Methods T2 - Language and the Scientific Imagination. The 11th International Conference of ISSEI, Language Centre, University of Helsinki (Finland) 28 July - 2 August 2008 Y1 - 2008 ER - TY - JOUR A1 - Slabu, Ioana A1 - Roeth, Anjali A. A1 - Engelmann, Ulrich M. A1 - Wiekhorst, Frank A1 - Buhl, Eva M. A1 - Neumann, Ulf P. A1 - Schmitz-Rode, Thomas T1 - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro JF - Nanotechnology Y1 - 2019 U6 - https://doi.org/10.1088/1361-6528/ab033e SN - 1361-6528 VL - 30 IS - 18 SP - 184004 ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Shasha, Carolyn A1 - Teeman, Eric A1 - Slabu, Iona A1 - Krishnan, Kannan M. T1 - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation JF - Journal of Magnetism and Magnetic Materials Y1 - 2019 U6 - https://doi.org/10.1016/j.jmmm.2018.09.041 SN - 0304-8853 VL - 471 IS - 1 SP - 450 EP - 456 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Seifert, Julian A1 - Mues, Benedikt A1 - Roitsch, Stefan A1 - Ménager, Christine A1 - Schmidt, Annette M. A1 - Slabu, Ioana T1 - Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels JF - Journal of Magnetism and Magnetic Materials Y1 - 2019 U6 - https://doi.org/10.1016/j.jmmm.2018.09.113 SN - 0304-8853 VL - 471 IS - 1 SP - 486 EP - 494 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Roeth, Anjali A.J. A1 - Eberbeck, Dietmar A1 - Buhl, Eva Miriam A1 - Neumann, Ulf Peter A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells JF - Scientific Reports N2 - Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95% was achieved by depositing an intracellular total thermal energy with about 50% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65% after MNP were internalized inside cells. Y1 - 2018 U6 - https://doi.org/10.1038/s41598-018-31553-9 SN - 2045-2322 VL - 8 IS - 1 SP - Article number 13210 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Buhl, Eva Miriam A1 - Draack, Sebastian A1 - Viereck, Thilo A1 - Frank, A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications JF - IEEE Magnetic Letters N2 - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy. Y1 - 2018 U6 - https://doi.org/10.1109/LMAG.2018.2879034 SN - 1949-307X VL - 9 IS - Article number 8519617 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Buhl, Eva Miriam A1 - Baumann, Martin A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia JF - Current Directions in Biomedical Engineering Y1 - 2017 U6 - https://doi.org/10.1515/cdbme-2017-0096 SN - 2364-5504 VL - 3 IS - 2 SP - 457 EP - 460 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Chen, Chao A1 - Jost, Peter A1 - Volker, Hanno A1 - Kaminski, Marvin A1 - Wirtssohn, Matti R. A1 - Engelmann, Ulrich M. A1 - Krüger, K. A1 - Schlich, Franziska F. A1 - Schlockermann, Carl A1 - Lobo, Ricardo P.S.M. A1 - Wuttig, Matthias T1 - Dielectric properties of amorphous phase-change materials JF - Physical Review B Y1 - 2017 U6 - https://doi.org/10.1103/PhysRevB.95.094111 SN - 2469-9950 VL - 95 IS - 9 SP - Article number 094111 ER - TY - JOUR A1 - Dantism, Shahriar A1 - Röhlen, Desiree A1 - Wagner, Torsten A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - A LAPS-based differential sensor for parallelized metabolism monitoring of various bacteria JF - Sensors N2 - Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH value variation during the measurements. Furthermore, calibration curves of the cellular metabolism were established as a function of the glucose concentration or cell number variation with all three model microorganisms. In this context, simultaneous (bio)sensing with the multi-organism LAPS-based set-up can open new possibilities for a cost-effective, rapid detection of the extracellular acidification of bacteria on a single sensor chip. It can be applied to evaluate the metabolic response of bacteria populations in a (bio)fermentation process, for instance, in the biogas fermentation process. Y1 - 2019 U6 - https://doi.org/10.3390/s19214692 SN - 1424-8220 VL - 19 IS - 21 PB - MDPI CY - Basel ER - TY - JOUR A1 - Karschuck, T. L. A1 - Filipov, Y. A1 - Bollella, P. A1 - Schöning, Michael Josef A1 - Katz, E. T1 - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction JF - International Journal of Unconventional Computing N2 - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions. Y1 - 2019 SN - 1548-7199 VL - 14 IS - 3-4 SP - 235 EP - 242 PB - Old City Publishing CY - Philadelphia ER - TY - THES A1 - Engelmann, Ulrich M. T1 - Assessing magnetic fluid hyperthermia : magnetic relaxation simulation, modeling of nanoparticle uptake inside pancreatic tumor cells and in vitro efficacy Y1 - 2019 SN - 978-3-945954-58-4 N1 - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2019 PB - Infinite Science Publishing CY - Lübeck ER - TY - CHAP A1 - Gerhards, Benjamin A1 - Schleser, Markus A1 - Otten,, Christian A1 - Schwarz, Alexander A1 - Gebhardt, Andreas T1 - Innovative Laser Beam Joining Technology for Additive Manufactured Parts T2 - Conference Proceedings 72nd IIW Annual Assembly and International Conference, 7-12 July 2019, Bratislava Y1 - 2019 SP - 1 EP - 8 ER - TY - CHAP A1 - Gerhards, Benjamin A1 - Schleser, Markus A1 - Otten, Christian T1 - Advancements of mobile vacuum laser welding for industrial thick sheet applications T2 - Conference Proceedings 72nd IIW Annual Assembly and International Conference, 7-12 July 2019, Bratislava Y1 - 2019 SP - 1 EP - 8 ER - TY - CHAP A1 - Matcha, Heike A1 - Barczik, Günter ED - Valena, Tomas ED - Avermaete, Tom ED - Vrachliotis, Georg T1 - Mass Diversity: Individualized housing via parametric typology T2 - Structuralism Reloaded? Rule-Based Design in Architecture and Urbanism Y1 - 2011 SN - 978-3-936681-47-5 SP - 354 EP - 358 PB - Edition Axel Menges CY - Fellbach ER - TY - CHAP A1 - Matcha, Heike A1 - Ljubas, Ante T1 - Parametric Origami: Adaptable temporary buildings T2 - Future cities: 28th eCAADe Conference Proceedings. eCAADe: Conferences. Zurich, Switzerland Y1 - 2010 SN - 978-0-9541183-7-2 SP - 243 EP - 251 ER - TY - CHAP A1 - Matcha, Heike A1 - Quasten, Gero T1 - A Parametric-Typological Tool: More Diversity for Mass Produced Single Family Homes Through Parametrized Design and Customized Mass Production T2 - Computation: The New Realm of Architectural Design [27th eCAADe Conference Proceedings Y1 - 2009 SN - 978-0-9541183-8-9 SP - 409 EP - 416 ER - TY - CHAP A1 - Karzer, Rüdiger A1 - Matcha, Heike T1 - Experimental design-build: teaching parameter-based design T2 - Computation: The New Realm of Architectural Design [27th eCAADe Conference Proceedings] Y1 - 2009 SN - 978-0-9541183-8-9 U6 - https://doi.org/10.52842/conf.ecaade.2009.153 SP - 153 EP - 158 ER - TY - CHAP A1 - Matcha, Heike T1 - Parametric possibilities: designing with parametric modelling T2 - Predicting the Future [25th eCAADe Conference Proceedings] Y1 - 2007 SN - 978-0-9541183-6-5 SP - 849 EP - 856 ER - TY - JOUR A1 - Kreyer, Jörg A1 - Müller, Marvin A1 - Esch, Thomas T1 - A Calculation Methodology for Predicting Exhaust Mass Flows and Exhaust Temperature Profiles for Heavy-Duty Vehicles JF - SAE International Journal of Commercial Vehicles N2 - The predictive control of commercial vehicle energy management systems, such as vehicle thermal management or waste heat recovery (WHR) systems, are discussed on the basis of information sources from the field of environment recognition and in combination with the determination of the vehicle system condition. In this article, a mathematical method for predicting the exhaust gas mass flow and the exhaust gas temperature is presented based on driving data of a heavy-duty vehicle. The prediction refers to the conditions of the exhaust gas at the inlet of the exhaust gas recirculation (EGR) cooler and at the outlet of the exhaust gas aftertreatment system (EAT). The heavy-duty vehicle was operated on the motorway to investigate the characteristic operational profile. In addition to the use of road gradient profile data, an evaluation of the continuously recorded distance signal, which represents the distance between the test vehicle and the road user ahead, is included in the prediction model. Using a Fourier analysis, the trajectory of the vehicle speed is determined for a defined prediction horizon. To verify the method, a holistic simulation model consisting of several hierarchically structured submodels has been developed. A map-based submodel of a combustion engine is used to determine the EGR and EAT exhaust gas mass flows and exhaust gas temperature profiles. All simulation results are validated on the basis of the recorded vehicle and environmental data. Deviations from the predicted values are analyzed and discussed. Y1 - 2020 U6 - https://doi.org/10.4271/02-13-02-0009 SN - 1946-3928 VL - 13 IS - 2 SP - 129 EP - 143 PB - SAE International CY - Warrendale, Pa. ER - TY - JOUR A1 - Fagan, Andrew J. A1 - Bitz, Andreas A1 - Björkman-Burtscher, Isabella M. A1 - Collins, Christopher M. A1 - Kimbrell, Vera A1 - Raaijmakers, Alexander J. E. T1 - 7T MR Safety JF - Journal of Magnetic Resonance Imaging (JMRI) Y1 - 2021 U6 - https://doi.org/10.1002/jmri.27319 SN - 1522-2586 VL - 53 IS - 2 SP - 333 EP - 346 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Henriques, A. A1 - Jurado, B. A1 - Grieser, M. A1 - Denis-Petit, D. A1 - Chiron, T. A1 - Gaudefroy, L. A1 - Glorius, J. A1 - Langer, Christoph A1 - Litvinov, Yu. A. A1 - Mathieu, L. A1 - Meot, V. A1 - Perez-Sanchez, R. A1 - Pibernat, J. A1 - Reifarth, R. A1 - Roig, O. A1 - Thomas, B. A1 - Thomas, B. A. A1 - Thomas, J. C. A1 - Tsekhanovich, I. T1 - Indirect measurements of neutron cross-secti at heavy-ion storage rings JF - Journal of Physics: Conference Series N2 - Cross sections for neutron-induced reactions of short-lived nuclei are essential for nuclear astrophysics since these reactions in the stars are responsible for the production of most heavy elements in the universe. These reactions are also key in applied domains like energy production and medicine. Nevertheless, neutron-induced cross-section measurements can be extremely challenging or even impossible to perform due to the radioactivity of the targets involved. Indirect measurements through the surrogate-reaction method can help to overcome these difficulties. The surrogate-reaction method relies on the use of an alternative reaction that will lead to the formation of the same excited nucleus as in the neutron-induced reaction of interest. The decay probabilities (for fission, neutron and gamma-ray emission) of the nucleus produced via the surrogate reaction allow one to constrain models and the prediction of the desired neutron cross sections. We propose to perform surrogate reaction measurements in inverse kinematics at heavy-ion storage rings, in particular at the CRYRING@ESR of the GSI/FAIR facility. We present the conceptual idea of the most promising setup to measure for the first time simultaneously the fission, neutron and gamma-ray emission probabilities. The results of the first simulations considering the 238U(d,d') reaction are shown, as well as new technical developments that are being carried out towards this set-up. Y1 - 2020 U6 - https://doi.org/10.1088/1742-6596/1668/1/012019 VL - 1668 IS - Art. 012019 PB - IOP CY - Bristol ER - TY - JOUR A1 - Varga, Laszlo A1 - Davinson, Thomas A1 - Glorius, Jan A1 - Jurado, Beatrix A1 - Langer, Christoph A1 - Lederer-Woods, Claudia A1 - Litvinov, Yuri A. A1 - Reifarth, Rene A1 - Slavkovska, Zuzana A1 - Stöhlker, Thomas A1 - Woods, Phil J. A1 - Xing, Yuan Ming T1 - Towards background-free studies of capture reaction in a heavy-ion storage ring JF - Journal of Physics: Conference Series N2 - Stored and cooled, highly-charged ions offer unprecedented capabilities for precision studies in the realm of atomic, nuclear structure and astrophysics[1]. After the successful investigation of the 96Ru(p,7)97Rh reaction cross section in 2009[2], the first measurement of the 124Xe(p,7)125Cs reaction cross section has been performed with decelerated, fully-ionized 124Xe ions in 2016 at the Experimental Storage Ring (ESR) of GSI[3]. Using a Double Sided Silicon Strip Detector, introduced directly into the ultra-high vacuum environment of a storage ring, the 125Cs proton-capture products have been successfully detected. The cross section has been measured at 5 different energies between 5.5AMeV and 8AMeV, on the high energy tail of the Gamow-window for hot, explosive scenarios such as supernovae and X-ray binaries. The elastic scattering on the H2 gas jet target is the major source of background to count the (p,7) events. Monte Carlo simulations show that an additional slit system in the ESR in combination with the energy information of the Si detector will enable background free measurements of the proton-capture products. The corresponding hardware is being prepared and will increase the sensitivity of the method tremendously. Y1 - 2020 VL - 1668 IS - Art 012046 PB - IOP CY - Bristol ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Meskemper, Joshua A1 - Albracht, Kirsten A1 - Abel, Thomas A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs JF - Journal of Electromyography and Kinesiology N2 - Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA. Y1 - 2020 U6 - https://doi.org/10.1016/j.jelekin.2020.102402 SN - 1050-6411 VL - 51 IS - Article 102402 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wollbrink, Moritz A1 - Maslo, Semir A1 - Zimmer, Daniel A1 - Abbas, Karim A1 - Arntz, Kristian A1 - Bergs, Thomas T1 - Clamping and substrate plate system for continuous additive build-up and post-processing of metal parts JF - Procedia CIRP N2 - The manufacturing share of laser powder bed fusion (L-PBF) increases in industrial application, but still many process steps are manually operated. Additionally, it is not possible to achieve tight dimensional tolerances or low surfaces roughness. Hence, a process chain has to be set up to combine additive manufacturing (AM) with further machining technologies. To achieve a continuous workpiece flow as basis for further industrialization of L-PBF, the paper presents a novel substrate system and its application on L-PBF machines and post-processing. The substrate system consists of a zero-point clamping system and a matrix-like interface of contact pins to be substantially connected to the workpiece within the L-PBF process. Y1 - 2020 U6 - https://doi.org/10.1016/j.procir.2020.04.015 SN - 2212-8271 VL - 93 SP - 108 EP - 113 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Meyer, Max-Arno A1 - Granrath, Christian A1 - Feyerl, Günter A1 - Richenhagen, Johannes A1 - Kaths, Jakob A1 - Andert, Jakob T1 - Closed-loop platoon simulation with cooperative intelligent transportation systems based on vehicle-to-X communication JF - Simulation Modelling Practice and Theory Y1 - 2021 U6 - https://doi.org/10.1016/j.simpat.2020.102173 SN - 1569-190X VL - 106 IS - Art. 102173 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Serror, Martin A1 - Hack, Sacha A1 - Henze, Martin A1 - Schuba, Marko A1 - Wehrle, Klaus T1 - Challenges and Opportunities in Securing the Industrial Internet of Things JF - IEEE Transactions on Industrial Informatics Y1 - 2021 U6 - https://doi.org/10.1109/TII.2020.3023507 SN - 1941-0050 VL - 17 IS - 5 SP - 2985 EP - 2996 PB - IEEE CY - New York ER - TY - JOUR A1 - Kopp, Alexander A1 - Schunck, Laura A1 - Gosau, Martin A1 - Smeets, Ralf A1 - Burg, Simon A1 - Fuest, Sandra A1 - Kröger, Nadja A1 - Zinser, Max A1 - Krohn, Sebastian A1 - Behbahani, Mehdi A1 - Köpf, Marius A1 - Lauts, Lisa A1 - Rutkowski, Rico T1 - Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes JF - International Journal of Molecular Sciences N2 - In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes. Y1 - 2020 U6 - https://doi.org/10.3390/ijms21186704 SN - 1422-0067 N1 - Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine VL - 21 IS - 18 art. no. 6704 PB - MDPI CY - Basel ER - TY - CHAP A1 - Bozakov, Zdravko A1 - Sander, Volker T1 - OpenFlow: A Perspective for Building Versatile Networks T2 - Network-Embedded Management and Applications Y1 - 2013 SN - 978-1-4419-6769-5 U6 - https://doi.org/10.1007/978-1-4419-6769-5_11 SP - 217 EP - 245 PB - Springer CY - New York, NY ER - TY - CHAP A1 - Fateri, Miranda A1 - Gebhardt, Andreas T1 - Introduction to Additive Manufacturing T2 - 3D Printing of Optical Components N2 - Additive manufacturing (AM) works by creating objects layer by layer in a manner similar to a 2D printer with the “printed” layers stacked on top of each other. The layer-wise manufacturing nature of AM enables fabrication of freeform geometries which cannot be fabricated using conventional manufacturing methods as a one part. Depending on how each layer is created and bonded to the adjacent layers, different AM methods have been developed. In this chapter, the basic terms, common materials, and different methods of AM are described, and their potential applications are discussed. KW - Additive manufacturing KW - 3D printing KW - Digital manufacturing KW - Rapid prototyping KW - Rapid manufacturing Y1 - 2020 SN - 978-3-030-58960-8 U6 - https://doi.org/10.1007/978-3-030-58960-8_1 SP - 1 EP - 22 PB - Springer CY - Cham ER - TY - JOUR A1 - Fiedler, Thomas M. A1 - Ladd, Mark E. A1 - Clemens, Markus A1 - Bitz, Andreas T1 - Safety of subjects during radiofrequency exposure in ultra-high-field magnetic resonance imaging JF - IEEE Letters on Electromagnetic Compatibility Practice and Applications N2 - Magnetic resonance imaging (MRI) is one of the most important medical imaging techniques. Since the introduction of MRI in the mid-1980s, there has been a continuous trend toward higher static magnetic fields to obtain i.a. a higher signal-to-noise ratio. The step toward ultra-high-field (UHF) MRI at 7 Tesla and higher, however, creates several challenges regarding the homogeneity of the spin excitation RF transmit field and the RF exposure of the subject. In UHF MRI systems, the wavelength of the RF field is in the range of the diameter of the human body, which can result in inhomogeneous spin excitation and local SAR hotspots. To optimize the homogeneity in a region of interest, UHF MRI systems use parallel transmit systems with multiple transmit antennas and time-dependent modulation of the RF signal in the individual transmit channels. Furthermore, SAR increases with increasing field strength, while the SAR limits remain unchanged. Two different approaches to generate the RF transmit field in UHF systems using antenna arrays close and remote to the body are investigated in this letter. Achievable imaging performance is evaluated compared to typical clinical RF transmit systems at lower field strength. The evaluation has been performed under consideration of RF exposure based on local SAR and tissue temperature. Furthermore, results for thermal dose as an alternative RF exposure metric are presented. Y1 - 2020 SN - 2637-6423 U6 - https://doi.org/10.1109/LEMCPA.2020.3029747 VL - 2 IS - 3 SP - 1 EP - 8 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Molinnus, Denise A1 - Beging, Stefan A1 - Lowis, Carsten A1 - Schöning, Michael Josef T1 - Towards a multi-enzyme capacitive field-effect biosensor by comparative study of drop-coating and nano-spotting technique JF - Sensors N2 - Multi-enzyme immobilization onto a capacitive field-effect biosensor by nano-spotting technique is presented. The nano-spotting technique allows to immobilize different enzymes simultaneously on the sensor surface with high spatial resolution without additional photolithographical patterning. The amount of applied enzymatic cocktail on the sensor surface can be tailored. Capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors with Ta2O5 as pH-sensitive transducer layer have been chosen to immobilize the three different (pL droplets) enzymes penicillinase, urease, and glucose oxidase. Nano-spotting immobilization is compared to conventional drop-coating method by defining different geometrical layouts on the sensor surface (fully, half-, and quarter-spotted). The drop diameter is varying between 84 µm and 102 µm, depending on the number of applied drops (1 to 4) per spot. For multi-analyte detection, penicillinase and urease are simultaneously nano-spotted on the EIS sensor. Sensor characterization was performed by C/V (capacitance/voltage) and ConCap (constant capacitance) measurements. Average penicillin, glucose, and urea sensitivities for the spotted enzymes were 81.7 mV/dec, 40.5 mV/dec, and 68.9 mV/dec, respectively. Y1 - 2020 SN - 1424-8220 U6 - https://doi.org/10.3390/s20174924 N1 - Special issue: Multisensor Systems and Signal Processing in Analytical Chemistry VL - 20 IS - 17 PB - MDPI CY - Basel ER - TY - CHAP A1 - Chavez Bermudez, Victor Francisco A1 - Wollert, Jörg T1 - Gateway for Automation Controllers and Cloud based Voice Recognition Services T2 - KommA, 10. Jahreskolloquium Kommunikation in der Automation Y1 - 2019 SN - 978-3-944722-85-6 SP - 1 EP - 8 PB - Institut für Automation und Kommunikation CY - Magdeburg ER - TY - CHAP A1 - Geiben, Benedikt A1 - Götten, Falk A1 - Havermann, Marc T1 - Aerodynamic analysis of a winged sub-orbital spaceplane N2 - This paper primarily presents an aerodynamic CFD analysis of a winged spaceplane geometry based on the Japanese Space Walker proposal. StarCCM was used to calculate aerodynamic coefficients for a typical space flight trajectory including super-, trans- and subsonic Mach numbers and two angles of attack. Since the solution of the RANS equations in such supersonic flight regimes is still computationally expensive, inviscid Euler simulations can principally lead to a significant reduction in computational effort. The impact on accuracy of aerodynamic properties is further analysed by comparing both methods for different flight regimes up to a Mach number of 4. Y1 - 2020 U6 - https://doi.org/10.25967/530170 N1 - 69. Deutscher Luft- und Raumfahrtkongress 2020, 1. September 2020 - 3. September 2020, online PB - DGLR CY - Bonn ER - TY - BOOK A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef ED - Yoshinobu, Tatsuo ED - Schöning, Michael Josef T1 - Light-addressing and chemical imaging technologies for electrochemical sensing Y1 - 2020 SN - 978-3-03943-029-1 U6 - https://doi.org/10.3390/books978-3-03943-029-1 N1 - This book is a printed edition of the Special Issue Light-Addressing and Chemical Imaging Technologies for Electrochemical Sensing that was published in Sensors PB - MDPI CY - Basel ER - TY - CHAP A1 - Frantz, Cathy A1 - Binder, Matthias A1 - Busch, Konrad A1 - Ebert, Miriam A1 - Heinrich, Andreas A1 - Kaczmarkiewicz, Nadine A1 - Schlögl-Knothe, Bärbel A1 - Kunze, Tobias A1 - Schuhbauer, Christian A1 - Stetka, Markus A1 - Schwager, Christian A1 - Spiegel, Michael A1 - Teixeira Boura, Cristiano José A1 - Bauer, Thomas A1 - Bonk, Alexander A1 - Eisen, Stefan A1 - Funck, Bernhard T1 - Basic Engineering of a High Performance Molten Salt Tower Receiver System T2 - AIP Conference Proceedings N2 - The production of dispatchable renewable energy will be one of the most important key factors of the future energy supply. Concentrated solar power (CSP) plants operated with molten salt as heat transfer and storage media are one opportunity to meet this challenge. Due to the high concentration factor of the solar tower technology the maximum process temperature can be further increased which ultimately decreases the levelized costs of electricity of the technology (LCOE). The development of an improved tubular molten salt receiver for the next generation of molten salt solar tower plants is the aim of this work. The receiver is designed for a receiver outlet temperature up to 600 °C. Together with a complete molten salt system, the receiver will be integrated into the Multi-Focus-Tower (MFT) in Jülich (Germany). The paper describes the basic engineering of the receiver, the molten salt tower system and a laboratory corrosion setup. Y1 - 2020 U6 - https://doi.org/10.1063/5.0085895 N1 - SOLARPACES 2020: 26th International Conference on Concentrating Solar Power and Chemical Energy Systems, 28 September – 2 October 2020, Freiburg, Germany SP - 1 EP - 10 ER - TY - JOUR A1 - Hüning, Felix A1 - Backes, Andreas T1 - Direct observation of large Barkhausen jump in thin Vicalloy wires JF - IEEE Magnetics Letters Y1 - 2020 SN - 1949-307X U6 - https://doi.org/10.1109/LMAG.2020.3046411 VL - 11 IS - Art. 2506504 SP - 1 EP - 4 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Gazda, Quentin A1 - Maurischat, Andreas T1 - Special functions and Gauss-Thakur sums in higher rank and dimension Y1 - 2020 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Gebhardt, Andreas A1 - Hoetter, Jan-Steffen T1 - Rapid Tooling T2 - CIRP Encyclopedia of Production Engineering Y1 - 2019 SN - 978-3-662-53120-4 U6 - https://doi.org/10.1007/978-3-662-53120-4 SP - 39 EP - 52 PB - Springer CY - Berlin, Heidelberg ER - TY - CHAP A1 - Chavez Bermudez, Victor Francisco A1 - Wollert, Jörg T1 - Arduino based Framework for Rapid Application Development of a Generic IO-Link interface T2 - Kommunikation und Bildverarbeitung in der Automation. Ausgewählte Beiträge der Jahreskolloquien KommA und BVAu 2018 N2 - The implementation of IO-Link in the automation industry has increased over the years. Its main advantage is it offers a digital point-to-point plugand-play interface for any type of device or application. This simplifies the communication between devices and increases productivity with its different features like self-parametrization and maintenance. However, its complete potential is not always used. The aim of this paper is to create an Arduino based framework for the development of generic IO-Link devices and increase its implementation for rapid prototyping. By generating the IO device description file (IODD) from a graphical user interface, and further customizable options for the device application, the end-user can intuitively develop generic IO-Link devices. The peculiarity of this framework relies on its simplicity and abstraction which allows to implement any sensor functionality and virtually connect any type of device to an IO-Link master. This work consists of the general overview of the framework, the technical background of its development and a proof of concept which demonstrates the workflow for its implementation. Y1 - 2020 SN - 978-3-662-59895-5 SN - 978-3-662-59894-8 U6 - https://doi.org/10.1007/978-3-662-59895-5_2 N1 - Beiträge der Jahreskolloquien KommA und BVAu 2018; Teil der Buchserie "Technologien für die intelligente Automation" (TIA,volume 12) SP - 21 EP - 33 PB - Springer Vieweg CY - Berlin ER - TY - JOUR A1 - Conzen, Catharina A1 - Albanna, Walid A1 - Weiss, Miriam A1 - Kürten, David A1 - Vilser, Walthard A1 - Kotliar, Konstantin A1 - Zäske, Charlotte A1 - Clusmann, Hans A1 - Schubert, Gerrit Alexander T1 - Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes JF - Translational Stroke Research N2 - Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5–14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome. Y1 - 2018 U6 - https://doi.org/10.1007/s12975-017-0585-8 SN - 1868-601X IS - 9 SP - 284 EP - 293 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Bernecker, Andreas A1 - Boyer, Pierre C. A1 - Gathmann, Christina T1 - The Role of Electoral Incentives for Policy Innovation: Evidence from the US Welfare Reform JF - American Economic Journal: Economic Policy Y1 - 2021 U6 - https://doi.org/10.1257/pol.20190690 SN - 1945-774X VL - 13 IS - 2 SP - 26 EP - 57 PB - American Economic Association CY - Nashville, Tenn. ER - TY - CHAP A1 - Hoegen, Anne von A1 - Doncker, Rik W. De A1 - Bragard, Michael A1 - Hoegen, Svenja von T1 - Problem-based learning in automation engineering: performing a remote laboratory aession aerving various educational attainments T2 - 2021 IEEE Global Engineering Education Conference (EDUCON) N2 - During the Covid-19 pandemic, vocational colleges, universities of applied science and technical universities often had to cancel laboratory sessions requiring students’ attendance. These above of all are of decisive importance in order to give learners an understanding of theory through practical work.This paper is a contribution to the implementation of distance learning for laboratory work applicable for several upper secondary educational facilities. Its aim is to provide a paradigm for hybrid teaching to analyze and control a non-linear system depicted by a tank model. For this reason, we redesign a full series of laboratory sessions on the basis of various challenges. Thus, it is suitable to serve different reference levels of the European Qualifications Framework (EQF).We present problem-based learning through online platforms to compensate the lack of a laboratory learning environment. With a task deduced from their future profession, we give students the opportunity to develop own solutions in self-defined time intervals. A requirements specification provides the framework conditions in terms of time and content for students having to deal with the challenges of the project in a self-organized manner with regard to inhomogeneous previous knowledge. If the concept of Complete Action is introduced in classes before, they will automatically apply it while executing the project.The goal is to combine students’ scientific understanding with a procedural knowledge. We suggest a series of remote laboratory sessions that combine a problem formulation from the subject area of Measurement, Control and Automation Technology with a project assignment that is common in industry by providing extracts from a requirements specification. Y1 - 2021 U6 - https://doi.org/10.1109/EDUCON46332.2021.9453925 N1 - 2021 IEEE Global Engineering Education Conference (EDUCON), 21-23 April 2021, Vienna, Austria SP - 1605 EP - 1614 PB - IEEE CY - New York, NY ER - TY - CHAP A1 - Hüning, Felix A1 - Stüttgen, Marcel T1 - Work in Progress: Interdisciplinary projects in times of COVID-19 crisis – challenges, risks and chances T2 - 2021 IEEE Global Engineering Education Conference (EDUCON) N2 - Project work and inter disciplinarity are integral parts of today's engineering work. It is therefore important to incorporate these aspects into the curriculum of academic studies of engineering. At the faculty of Electrical Engineering and Information Technology an interdisciplinary project is part of the bachelor program to address these topics. Since the summer term 2020 most courses changed to online mode during the Covid-19 crisis including the interdisciplinary projects. This online mode introduces additional challenges to the execution of the projects, both for the students as well as for the lecture. The challenges, but also the risks and chances of this kind of project courses are subject of this paper, based on five different interdisciplinary projects Y1 - 2021 U6 - https://doi.org/10.1109/EDUCON46332.2021.9454006 N1 - 2021 IEEE Global Engineering Education Conference (EDUCON), 21-23 April 2021, Vienna, Austria SP - 1175 EP - 1179 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Hugenroth, Kristin A1 - Borchardt, Ralf A1 - Ritter, Philine A1 - Groß‑Hardt, Sascha A1 - Meyns, Bart A1 - Verbelen, Tom A1 - Steinseifer, Ulrich A1 - Kaufmann, Tim A. S. A1 - Engelmann, Ulrich M. T1 - Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input JF - Scientific Reports N2 - Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-96397-2 SN - 2045-2322 VL - 11 IS - Art. No. 16800 SP - 1 EP - 12 PB - Springer CY - Berlin ER - TY - CHAP A1 - Merkens, Torsten A1 - Hebel, Christoph T1 - Sharing mobility concepts – flexible, sustainable, smart T2 - Proceedings of the 1st UNITED – Southeast Asia Automotive Interest Group (SAIG) International Conference KW - Sharing mobility KW - electro mobility KW - business models KW - mobility behaviour Y1 - 2021 SN - 978-3-902103-94-9 N1 - 1st UNITED-SAIG International Conference, 21-22 APR 2021, Chulalongkorn University, Thailand SP - 43 EP - 44 ER - TY - JOUR A1 - Brockhaus, Moritz K. A1 - Behbahani, Mehdi A1 - Muris, Farina A1 - Jansen, Sebastian V. A1 - Schmitz- Rode, Thomas A1 - Steinseifer, Ulrich A1 - Clauser, Johanna C. T1 - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept JF - Artificial Organs N2 - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential. Y1 - 2021 U6 - https://doi.org/10.1111/aor.14046 SN - 1525-1594 VL - 45 IS - 12 SP - 1513 EP - 1521 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Olderog, M. A1 - Mohr, P. A1 - Beging, Stefan A1 - Tsoumpas, C. A1 - Ziemons, Karl T1 - Simulation study on the role of tissue-scattered events in improving sensitivity for a compact time of flight compton positron emission tomograph T2 - 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) N2 - In positron emission tomography improving time, energy and spatial detector resolutions and using Compton kinematics introduces the possibility to reconstruct a radioactivity distribution image from scatter coincidences, thereby enhancing image quality. The number of single scattered coincidences alone is in the same order of magnitude as true coincidences. In this work, a compact Compton camera module based on monolithic scintillation material is investigated as a detector ring module. The detector interactions are simulated with Monte Carlo package GATE. The scattering angle inside the tissue is derived from the energy of the scattered photon, which results in a set of possible scattering trajectories or broken line of response. The Compton kinematics collimation reduces the number of solutions. Additionally, the time of flight information helps localize the position of the annihilation. One of the questions of this investigation is related to how the energy, spatial and temporal resolutions help confine the possible annihilation volume. A comparison of currently technically feasible detector resolutions (under laboratory conditions) demonstrates the influence on this annihilation volume and shows that energy and coincidence time resolution have a significant impact. An enhancement of the latter from 400 ps to 100 ps leads to a smaller annihilation volume of around 50%, while a change of the energy resolution in the absorber layer from 12% to 4.5% results in a reduction of 60%. The inclusion of single tissue-scattered data has the potential to increase the sensitivity of a scanner by a factor of 2 to 3 times. The concept can be further optimized and extended for multiple scatter coincidences and subsequently validated by a reconstruction algorithm. Y1 - 2021 SN - 978-1-7281-7693-2 U6 - https://doi.org/10.1109/NSS/MIC42677.2020.9507901 N1 - 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 31 Oct.-7 Nov. 2020, Boston, MA, USA PB - IEEE CY - New York, NY ER - TY - CHAP A1 - Adams, Moritz A1 - Losekamm, Martin J. A1 - Czupalla, Markus T1 - Development of the Thermal Control System for the RadMap Telescope Experiment on the International Space Station T2 - International Conference on Environmental Systems Y1 - 2020 N1 - 2020 International Conference on Environmental Systems, 12. Juli 2020 – 16. Juli 2020, Lissabon SP - 1 EP - 10 ER - TY - JOUR A1 - Arampatzis, Adamantios A1 - Karamanidis, Kiros A1 - Albracht, Kirsten T1 - Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude JF - Journal of Experimental Biology Y1 - 2007 U6 - https://doi.org/10.1242/jeb.003814 SN - 0022-0949 VL - 210 IS - 15 SP - 2743 EP - 2753 ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy JF - Biological Cybernetics Y1 - 2006 U6 - https://doi.org/10.1007/s00422-006-0070-z SN - 1432-0770 VL - 95 IS - 1 SP - 87 EP - 96 ER - TY - CHAP A1 - Bitz, Andreas A1 - Streckert, J. A1 - Hansen, V.W. A1 - Buschmann, J. T1 - RF exposure of non restrained animals in an overmoded radial waveguide T2 - 22nd BEMS Annual Meeting, Munich, Germany, 2000 Y1 - 2000 SP - 63 PB - Bioelectromagnetics Society CY - Frederick, MD ER - TY - JOUR A1 - Sousa, Marcos A. M. A1 - Siqueira, Jose R. Jr. A1 - Vercik, Andres A1 - Schöning, Michael Josef A1 - Oliveira, Osvaldo N. Jr. T1 - Determining the optimized layer-by-layer film architecture with dendrimer/carbon nanotubes for field-effect sensors JF - IEEE Sensors Journal N2 - The capacitive electrolyte–insulator–semiconductor (EIS) structure is a typical device based on a field-effect sensor platform. With a simple silicon-based structure, EIS have been useful for several sensing applications, especially with incorporation of nanostructured films to modulate the ionic transport and the flat-band potential. In this paper, we report on ion transport and changes in flat-band potential in EIS sensors made with layer-by-layer films containing poly(amidoamine) (PAMAM) dendrimer and single-walled carbon nanotubes (SWNTs) adsorbed on p-Si/SiO 2 /Ta 2 O 5 chips with an Al ohmic contact. The impedance spectra were fitted using an equivalent circuit model, from which we could determine parameters such as the double-layer capacitance. This capacitance decreased with the number of bilayers owing to space charge accumulated at the electrolyte–insulator interface, up to three PAMAM/SWNTs bilayers, after which it stabilized. The charge-transfer resistance was also minimum for three bilayers, thus indicating that this is the ideal architecture for an optimized EIS performance. The understanding of the influence of nanostructures and the fine control of operation parameters pave the way for optimizing the design and performance of new EIS sensors. Y1 - 2017 U6 - https://doi.org/10.1109/JSEN.2017.2653238 SN - 1558-1748 VL - 17 IS - 6 SP - 1735 EP - 1740 PB - IEEE CY - New York ER - TY - CHAP A1 - Schwanke, Peter A1 - Höfken, Hans-Wilhelm A1 - Schuba, Marko T1 - Security Analysis of the ADS Protocol of a Beckhoff CX2020 PLC N2 - ICSs (Industrial Control Systems) and its subset SCADA systems (Supervisory Control and Data Acquisition) are getting exposed to a constant stream of new threats. The increasing importance of IT security in ICS requires viable methods to assess the security of ICS, its individual components, and its protocols. This paper presents a security analysis with focus on the communication protocols of a single PLC (Programmable Logic Controller). The PLC, a Beckhoff CX2020, is examined and new vulnerabilities of the system are revealed. Based on these findings recommendations are made to improve security of the Beckhoff system and its protocols. Y1 - 2017 N1 - International Conference on Computer, Network Security and Communication Engineering (CNSCE 2017), March 26-27, 2017, Bangkok, Thailand SP - 1 EP - 5 ER - TY - CHAP A1 - Granat, Andreas A1 - Höfken, Hans-Wilhelm A1 - Schuba, Marko T1 - Intrusion Detection of the ICS Protocol EtherCAT N2 - Control mechanisms like Industrial Controls Systems (ICS) and its subgroup SCADA (Supervisory Control and Data Acquisition) are a prerequisite to automate industrial processes. While protection of ICS on process management level is relatively straightforward – well known office IT security mechanisms can be used – protection on field bus level is harder to achieve as there are real-time and production requirements like 24x7 to consider. One option to improve security on field bus level is to introduce controls that help to detect and to react on attacks. This paper introduces an initial set of intrusion detection mechanisms for the field bus protocol EtherCAT. To this end existing Ethernet attack vectors including packet injection and man-in-the-middle attacks are tested in an EtherCAT environment, where they could interrupt the EtherCAT network and may even cause physical damage. Based on the signatures of such attacks, a preprocessor and new rule options are defined for the open source intrusion detection system Snort demonstrating the general feasibility of intrusion detection on field bus level. Y1 - 2017 N1 - International Conference on Computer, Network Security and Communication Engineering (CNSCE 2017), March 26-27, 2017, Bangkok, Thailand SP - 1 EP - 5 ER - TY - CHAP A1 - Bitz, Andreas A1 - Klomp, D.W. A1 - Ladd, M.E. T1 - Experimental and numerical determination of SAR and temperature distribution of a human endorectal coil for MR imaging of the prostate at 7T (903.) T2 - 16th annual ISMRM scientific meeting and exhibition 2008 : Toronto, Ontario, Canada, 3 - 9 May 2008 Y1 - 2009 SN - 978-1-61567-196-0 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Bitz, Andreas A1 - El Ouardi, A. A1 - Streckert, J. A1 - Hansen, V. T1 - Efficient calculation of human exposure in front of base station antennas by a combination of the FDTD and Hybrid(2)-method T2 - Proceedings of the 16th International Zurich Symposium on Electromagnetic Compatibility, Topical Meeting on Biomedical EMC, Zurich, Switzerland, February 2005 Y1 - 2005 SN - 3-9521199-9-7 SP - 115 EP - 118 PB - ETH Zentrum CY - Zürich ER - TY - CHAP A1 - Bitz, Andreas A1 - Alaydrus, M. A1 - Streckert, J. A1 - Hansen, V. T1 - Combination of the hybrid/sup [2]/-method and the FDTD-method for solution of boundary value problems with electrically large and high-resolution bodies T2 - IEEE Antennas and Propagation Society International Symposium (IEEE Cat. No.02CH37313) 2002 : San Antonio, TX, USA, 16-21 June Y1 - 2002 SN - 0-7803-7330-8 U6 - https://doi.org/10.1109/APS.2002.1018209 SP - 278 EP - 281 PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Bitz, Andreas A1 - Alaydrus, M. A1 - Streckert, J. A1 - Hansen, V.W. T1 - Absorption rates inside human body due to radiated electro-magnetic fields of multi-band base station antennas. Boundary value problems with electrically large and high-resolution bodies T2 - 24th BEMS Annual Meeting, Quebec City, Quebec, Canada, 23 - 27 June 2002 Y1 - 2002 SP - 40 EP - 41 PB - Bioelectromagnetics Society CY - Frederick, MD ER - TY - CHAP A1 - Bitz, Andreas A1 - Alaydrus, M. A1 - Streckert, J. A1 - Hansen, V.W. T1 - Base station antennas embedded in complex environments: rf exposure in controlled areas T2 - 23rd BEMS Annual Meeting, St. Paul, Minnesota, USA, 49-50, June 2001 Y1 - 2001 SP - 49 EP - 50 PB - Bioelectromagnetics Society CY - Frederick, MD ER - TY - CHAP A1 - Bitz, Andreas A1 - Streckert, J. A1 - Hansen, V.W. A1 - Stogbauer, F. ED - Hietanen, Maila ED - Jokela, Kari ED - Juutilainen, Jukka ED - Työterveyslaitos, T1 - Shielded RF-exposure system with an integrated LF-measuring system for in vitro experiments with cell-layers T2 - Proceedings of the Ebea 2001 : 5th International Congress of the European Bioelectromagnetics Association (Ebea) ; 6-8 September 2001, Marina Congress Center, Helsinki, Finland Y1 - 2001 SN - 9789518024401 SP - 67 EP - 68 PB - Finnish Institute of Occupational Health CY - Helsinki ER - TY - CHAP A1 - Bitz, Andreas A1 - Streckert, J.R. A1 - Hansen, V.W. A1 - Lerchl, A. ED - Danesy, Dorothea T1 - Freely moving or restrained animals in bioelec-tromagnetic experiments - pros and cons T2 - AP 2000 : Millennium Conference on Antennas & Propagation, Davos, Switzerland, 9 - 14 April 2000 Y1 - 2000 IS - Band 1 SP - 489 PB - ESA Publications Division, ESTEC CY - Noordwijk ER - TY - GEN A1 - Nobisrath, Ulrich A1 - Zündorf, Albert A1 - George, Tobias A1 - Ruben, Jubeh A1 - Kraft, Bodo T1 - Software Stories Guide N2 - Software Stories are a simple graphical notation for requirements analysis and design in agile software projects. Software Stories are based on example scenarios. Example scenarios facilitate the communication between lay people or domain experts and software experts. Y1 - 2017 ER - TY - JOUR A1 - Reinhardt, T. A1 - Bitz, Andreas A1 - El Ouardi, A. A1 - Streckert, J. A1 - Sommer, A. A1 - Lerchl, A. A1 - Hansen, V. T1 - Exposure set-ups for in vivo experiments using radial waveguides JF - Radiation Protection Dosimetry Y1 - 2007 U6 - https://doi.org/10.1093/rpd/ncm370 SN - 1742-3406 VL - 124 IS - 1 SP - 21 EP - 26 ER - TY - JOUR A1 - Sommer, Angela M. A1 - Bitz, Andreas A1 - Streckert, Joachim A1 - Hansen, Volkert W. A1 - Lerchl, Alexander T1 - Lymphoma development in mice chronically exposed to UMTS-modulated radiofrequency electromagnetic fields JF - Radiation Research Y1 - 2007 U6 - https://doi.org/10.1667/RR0857.1 SN - 1938-5404 VL - 168 IS - 1 SP - 72 EP - 80 ER - TY - JOUR A1 - Sukhotina, Irina A1 - Streckert, Joachim R. A1 - Bitz, Andreas A1 - Hansen, Volkert W. A1 - Lerchl, Alexander T1 - 1800 MHz electromagnetic field effects on melatonin release from isolated pineal glands JF - Journal of Pineal Research Y1 - 2006 U6 - https://doi.org/10.1111/j.1600-079X.2005.00284.x SN - 1600-079X VL - 40 IS - 1 SP - 86 EP - 91 ER - TY - JOUR A1 - Franke, Helmut A1 - Streckert, Joachim A1 - Bitz, Andreas A1 - Goeke, Johannes A1 - Hansen, Volkert A1 - Ringelstein, E. Bernd A1 - Nattkämper, Heiner A1 - Galle, Hans-Joachim A1 - Stögbauer, Florian T1 - Effects of Universal Mobile Telecommunications System (UMTS) electromagnetic fields on the blood-brain barrier in vitro JF - Radiation Research Y1 - 2005 U6 - https://doi.org/10.1667/RR3424.1 SN - 1938-5404 VL - 164 IS - 3 SP - 258 EP - 269 ER - TY - JOUR A1 - Wissen, M. A1 - Bogdanski, N. A1 - Scheer, H.-C. A1 - Bitz, Andreas A1 - Ahrens, G. A1 - Gruetzner, G. T1 - Implication of the light polarisation for UV curing of pre-patterned resists JF - Microelectronic Engineering Y1 - 2005 U6 - https://doi.org/10.1016/j.mee.2004.12.099 SN - 0167-9317 VL - 78-79 SP - 659 EP - 664 ER - TY - CHAP A1 - Wu, Ziyi A1 - Kemper, Hans T1 - The optimal 48 V – battery pack for a specific load profile of a heavy duty vehicle T2 - 8. Internationale Fachtagung Kraftwerk Batterie : 26. – 27. April 2016, Münster, Deutschland Y1 - 2016 ER - TY - CHAP A1 - Schirra, Julian A1 - Bauschat, J.-Michael A1 - Watmuff, J.H. T1 - Accurate induced drag prediction for highly non-planar lifting systems T2 - 19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia N2 - The impact of wake model effects is investigated for two highly non-planar lifting systems. Dependent on the geometrical arrangement of the configuration, the wake model shape is found to considerably affect the estimation. Particularly at higher angles of attack, an accurate estimation based on the common linear wake model approaches is involved. Y1 - 2014 ER - TY - CHAP A1 - Neu, Eugen A1 - Janser, Frank A1 - Khatibi, Akbar A. A1 - Orifici, Adrian C. T1 - In-flight vibration-based structural health monitoring of aircraft wings T2 - 30th Congress of the internatonal council of the aeronautical sciences : 25.-30. September 2016, Daejeon, Korea N2 - This work presents a methodology for automated damage-sensitive feature extraction and anomaly detection under multivariate operational variability for in-flight assessment of wings. The method uses a passive excitation approach, i. e. without the need for artificial actuation. The modal system properties (natural frequencies and damping ratios) are used as damage-sensitive features. Special emphasis is placed on the use of Fiber Bragg Grating (FBG) sensing technology and the consideration of Operational and Environmental Variability (OEV). Measurements from a wind tunnel investigation with a composite cantilever equipped with FBG and piezoelectric sensors are used to successfully detect an impact damage. In addition, the feasibility of damage localisation and severity estimation is evaluated based on the coupling found between damageand OEV-induced feature changes. Y1 - 2016 ER - TY - JOUR A1 - Ndoumbè Mbonjo Mbonjo, H. A1 - Streckert, J. A1 - Bitz, Andreas A1 - Hansen, V. A1 - Glasmachers, A. A1 - Gencol, S. A1 - Rozic, D. T1 - Generic UMTS test signal for RF bioelectromagnetic studies JF - Bioelectromagnetics Y1 - 2004 U6 - https://doi.org/10.1002/bem.20007 SN - 1521-186X VL - 25 IS - 6 SP - 415 EP - 425 ER - TY - JOUR A1 - Sommer, Angela M. A1 - Streckert, Joachim A1 - Bitz, Andreas A1 - Hansen, Volkert W. A1 - Lerchl, Alexander T1 - No effects of GSM-modulated 900 MHz electromagnetic fields on survival rate and spontaneous development of lymphoma in female AKR/J mice JF - BMC Cancer Y1 - 2004 U6 - https://doi.org/10.1186/1471-2407-4-77 VL - 77 IS - 4 ER - TY - JOUR A1 - Hansen, Volkert W. A1 - Bitz, Andreas A1 - Streckert, Joachim R. T1 - RF Exposure of Biological Systems in Radial Waveguides JF - IEEE Transactions on Electromagnetic Compatibility Y1 - 1999 U6 - https://doi.org/10.1109/15.809852 SN - 1558-187X VL - 41 IS - 4 SP - 487 EP - 493 ER - TY - CHAP A1 - Bitz, Andreas A1 - Kobus, Thiele A1 - Scheenen, Tom W. J. A1 - Ladd, Mark E. T1 - RF Safety of the Combination of a 31P Tx/Rx Endorectal Coil & a 1H Tx/Rx Body Array for 31P MRSI of the Prostate at 7T (311.) T2 - 20th Annual ISMRM scientific meeting and exhibition 2012 : Melbourne, Australia, 5 - 11 May 2012 Y1 - 2013 SN - 978-1-62276-943-8 SN - 1545-4428 IS - Volume 1 SP - 311 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Bitz, Andreas A1 - Kraff, O. A1 - Orzada, S. A1 - Maderwald, S. A1 - Brote, I. A1 - Johst, S. A1 - Ladd, E. T1 - Assessment of RF Safety of Transmit Coils at 7 Tesla by Experimental and Numerical Procedures (490.) T2 - 19th annual ISMRM scientific meeting and exhibition 2011 : Montreal, Quebec, Canada, 7 - 13 May 2011 Y1 - 2012 SN - 978-1-61839-284-8 IS - Volume 1 SP - 475 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Bitz, Andreas A1 - Kraff, O. A1 - Orzada, S. A1 - Maderwald, S. A1 - Brote, I. A1 - Ladd, M. T1 - Experimental and Numerical Assessment of RF Safety of Transmit Coils at 7 Tesla T2 - ISMRM workshop on MR safety 2010 : RF heating of the human in MRI : workshop series. The Washington County Historic Courthouse, Stillwater, Minnesota, USA, 15 - 17 October 2010 Y1 - 2010 SN - 978-1-62276-088-6 SP - 195 ER - TY - JOUR A1 - Arreola, Julio A1 - Oberländer, Jan A1 - Mätzkow, M. A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Surface functionalization for spore-based biosensors with organosilanes JF - Electrochimica Acta N2 - In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated. Y1 - 2017 U6 - https://doi.org/10.1016/j.electacta.2017.04.157 SN - 0013-4686 VL - 241 SP - 237 EP - 243 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Rieke, Christian A1 - Stollenwerk, Dominik A1 - Dahmen, Markus A1 - Pieper, Martin T1 - Modeling and optimization of a biogas plant for a demand-driven energy supply JF - Energy N2 - Due to the Renewable Energy Act, in Germany it is planned to increase the amount of renewable energy carriers up to 60%. One of the main problems is the fluctuating supply of wind and solar energy. Here biogas plants provide a solution, because a demand-driven supply is possible. Before running such a plant, it is necessary to simulate and optimize the process. This paper provides a new model of a biogas plant, which is as accurate as the standard ADM1 model. The advantage compared to ADM1 is that it is based on only four parameters compared to 28. Applying this model, an optimization was installed, which allows a demand-driven supply by biogas plants. Finally the results are confirmed by several experiments and measurements with a real test plant. Y1 - 2018 U6 - https://doi.org/10.1016/j.energy.2017.12.073 SN - 0360-5442 VL - 145 SP - 657 EP - 664 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Barnat, Miriam A1 - Bosse, Elke A1 - Tight, Malcolm T1 - The Guiding Role of Theory in Mixed-Methods Research: Combining Individual and Institutional Perspectives on the Transition to Higher Education T2 - Theory and Method in Higher Education Research. Vol 3 N2 - The methodological discourse of mixed-methods research offers general procedures to combine quantitative and qualitative methods for investigating complex fields of research such as higher education. However, integrating different methods still poses considerable challenges. To move beyond general recommendations for mixed-methods research, this chapter proposes to discuss methodological issues with respect to a particular research domain. Taking current studies on the transition to higher education as an example, the authors first provide an overview of the potentials and limitations of quantitative and qualitative methods in the research domain. Second, they show the need for a conceptual framework grounded in the theory of the research object to guide the integration of different methods and findings. Finally, an example study that investigates transition with regard to the interplay of the individual student and the institutional context serves to illustrate the guiding role of theory. The framework integrates different theoretical perspectives on transition, informs the selection of the research methods, and defines the nexus of the two strands that constitute the mixed-methods design. As the interplay of individual and context is of concern for teaching and learning in general, the example presented may be fruitful for the wider field of higher education research. KW - Quantitative research KW - Mixed-Methods Research KW - Transition KW - Students KW - Higher education Y1 - 2017 SN - 978-1-78743-222-2 U6 - https://doi.org/10.1108/S2056-375220170000003001 SP - 1 EP - 19 PB - Emerald Publishing Limited ER - TY - CHAP A1 - Barnat, Miriam A1 - Bosse, Elke T1 - The challenge of creating meta-inferences: Combining data representing institutional and individual perspectives on first-year support in higher education T2 - 9th Conference on Social Science Methodology of the International Sociological Association, Leicester, UK Y1 - 2016 N1 - RC33 Conference 2016 SP - 1 EP - 20 ER - TY - JOUR A1 - Oberländer, Jan A1 - Mayer, Marlena A1 - Greeff, Anton A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Spore-based biosensor to monitor the microbicidal efficacy of gaseous hydrogen peroxide sterilization processes JF - Biosensors and Bioelectronics N2 - In this work, a spore-based biosensor is evaluated to monitor the microbicidal efficacy of sterilization processes applying gaseous hydrogen peroxide (H2O2). The sensor is based on interdigitated electrode structures (IDEs) that have been fabricated by means of thin-film technologies. Impedimetric measurements are applied to study the effect of sterilization process on spores of Bacillus atrophaeus. This resilient microorganism is commonly used in industry to proof the sterilization efficiency. The sensor measurements are accompanied by conventional microbiological challenge tests, as well as morphological characterizations with scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The sensor measurements are correlated with the microbiological test routines. In both methods, namely the sensor-based and microbiological one, a tailing effect has been observed. The results are evaluated and discussed in a three-dimensional calibration plot demonstrating the sensor's suitability to enable a rapid process decision in terms of a successfully performed sterilization. Y1 - 2018 U6 - https://doi.org/10.1016/j.bios.2017.12.045 SN - 0956-5663 VL - 104 SP - 87 EP - 94 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Schmidts, Oliver A1 - Boltes, Maik A1 - Kraft, Bodo A1 - Schreiber, Marc T1 - Multi-pedestrian tracking by moving Bluetooth-LE beacons and stationary receivers T2 - 2017 International Conference on Indoor Positioning and Indoor Navigation (IPIN), 18-21 September 2017, Sapporo, Japan Y1 - 2017 N1 - International Conference on Indoor Positioning and Indoor Navigation <8, 2017, Sapporo, Japan> SP - 1 EP - 4 ER - TY - CHAP A1 - Kleine, Harald A1 - Kallweit, Stephan A1 - Michaux, Frank A1 - Havermann, Marc A1 - Olivier, Herbert T1 - PIV Measurement of Shock Wave Diffraction T2 - 18th International Symposium on Applications of Laser Techniques to Fluid Mechanics, 2016, Lissabon Y1 - 2016 SP - 1 EP - 14 ER - TY - CHAP A1 - Schleupen, Josef A1 - Engemann, Heiko A1 - Bagheri, Mohsen A1 - Kallweit, Stephan T1 - The potential of SMART climbing robot combined with a weatherproof cabin for rotor blade maintenance T2 - 17th European Conference on Composite Materials – ECCM, Munich, Germany Y1 - 2016 N1 - ECCM 17 SP - 1 EP - 8 ER - TY - JOUR A1 - Braband, Henrik A1 - Paulßen, Elisabeth A1 - Abram, Ulrich T1 - Nitridorhenium(V) Complexes with 1,3-Dialkyl-4,5-dimethylimidazole-2-ylidenes JF - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry Y1 - 2006 U6 - https://doi.org/10.1002/zaac.200600002 SN - 1521-3749 VL - 632 IS - 6 SP - 1051 EP - 1056 ER - TY - JOUR A1 - Paulßen, Elisabeth A1 - Schweighöfer, Philip V. A1 - Abram, Ulrich T1 - Reactions of [ReOX3(PPh3)2] Complexes (X = Cl, Br) with Phenylacetylene and the Structures of the Products JF - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry N2 - Oxorhenium(V) complexes [ReOX3(PPh3)2] (X = Cl, Br) react with phenylacetylene under formation of complexes with ylide-type ligands. Compounds of the compositions [ReOCl3(PPh3){C(Ph)C(H)(PPh3)}] (1), [ReOBr3(OPPh3){C(Ph)C(H)(PPh3)}] (2), and [ReOBr3(OPPh3){C(H)C(Ph)(PPh3)}] (3) were isolated and characterized by X-ray diffraction. They contain a ligand, which was formed by a nucleophilic attack of released PPh3 at coordinated phenylacetylene. The structures of the products show that there is no preferable position for this attack. Cleavage of the Re–C bond in 3 and dimerization of the organic ligand resulted in the formation of the [{(PPh3)(H)CC(Ph)}2]2+ cation, which crystallized as its [(ReOBr4)(OReO3)]2– salt. Y1 - 2010 U6 - https://doi.org/10.1002/zaac.200900478 SN - 1521-3749 VL - 636 IS - 5 SP - 779 EP - 783 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Paulßen, Elisabeth A1 - Kückmann, Theresa A1 - Abram, Ulrich T1 - Silver(I) Complexes of 1,3-Dialkyl-4,5-dimethylimidazol-2-ylidenes and their Use as Precursors for the Synthesis of Rhenium(V) NHC Complexes JF - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry Y1 - 2007 U6 - https://doi.org/10.1002/zaac.200700021 SN - 1521-3749 VL - 633 IS - 5-6 SP - 830 EP - 834 ER - TY - JOUR A1 - Braband, Henrik A1 - Yegen, Eda A1 - Paulßen, Elisabeth A1 - Abram, Ulrich T1 - [{ReN(PMe2Ph)3}{ReO3N}]2 – Structural Evidence for the Nitridotrioxorhenate(VII) Anion, [ReO3N]2− JF - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry Y1 - 2005 U6 - https://doi.org/10.1002/zaac.200500240 SN - 1521-3749 VL - 631 IS - 12 SP - 2408 EP - 2410 ER -