TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, M. A1 - Molin, D. G. M. A1 - Akker, N. M. S. van den A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation JF - Procedia Engineering N2 - A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system. Y1 - 2015 U6 - https://doi.org/10.1016/j.proeng.2015.08.815 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 948 EP - 951 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Tran, Thanh Ngoc A1 - Tolba, R. H. A1 - Staat, Manfred T1 - Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen JF - International biomechanics Y1 - 2015 U6 - https://doi.org/10.1080/23335432.2015.1049295 SN - 2333-5432 VL - Vol. 2 IS - Iss. 1 SP - 79 EP - 88 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Scheja, Sabrina A1 - Wu, Chunsheng A1 - Keusgen, Michael A1 - Mewes, Dieter A1 - Schöning, Michael Josef T1 - DNA Immobilization and Hybridization Detection by the Intrinsic Molecular Charge Using Capacitive Field-Effect Sensors Modified with a Charged Weak Polyelectrolyte Layer JF - Applied Materials & Interfaces N2 - Miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge favor the semiconductor field-effect platform as one of the most attractive approaches for the development of label-free DNA chips. In this work, a capacitive field-effect EIS (electrolyte–insulator–semiconductor) sensor covered with a layer-by-layer prepared, positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was used for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization. The negatively charged probe single-stranded DNA (ssDNA) molecules were electrostatically adsorbed onto the positively charged PAH layer, resulting in a preferentially flat orientation of the ssDNA molecules within the Debye length, thus yielding a reduced charge-screening effect and a higher sensor signal. Each sensor-surface modification step (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), reducing an unspecific adsorption by a blocking agent, incubation with noncomplementary DNA (ncDNA) solution) was monitored by means of capacitance–voltage and constant-capacitance measurements. In addition, the surface morphology of the PAH layer was studied by atomic force microscopy and contact-angle measurements. High hybridization signals of 34 and 43 mV were recorded in low-ionic strength solutions of 10 and 1 mM, respectively. In contrast, a small signal of 4 mV was recorded in the case of unspecific adsorption of fully mismatched ncDNA. The density of probe ssDNA and dsDNA molecules as well as the hybridization efficiency was estimated using the experimentally measured DNA immobilization and hybridization signals and a simplified double-layer capacitor model. The results of field-effect experiments were supported by fluorescence measurements, verifying the DNA-immobilization and hybridization event. Y1 - 2015 U6 - https://doi.org/10.1021/acsami.5b05146 VL - 36 IS - 7 SP - 20068 EP - 20075 PB - American Chemical Society CY - Washington, DC ER - TY - JOUR A1 - Wu, Chunsheng A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Werner, Frederik A1 - Schöning, Michael Josef T1 - Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer JF - Nanoscale N2 - A multi-spot (16 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al–p-Si–SiO2 structure modified with a weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. To achieve a preferentially flat orientation of DNA strands and thus, to reduce the distance between the DNA charge and MLAPS surface, the negatively charged probe single-stranded DNAs (ssDNA) were electrostatically adsorbed onto the positively charged PAH layer using a simple layer-by-layer (LbL) technique. In this way, more DNA charge can be positioned within the Debye length, yielding a higher sensor signal. The surface potential changes in each spot induced due to the surface modification steps (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), non-specific adsorption of mismatched ssDNA) were determined from the shifts of photocurrent–voltage curves along the voltage axis. A high sensor signal of 83 mV was registered after immobilization of probe ssDNA onto the PAH layer. The hybridization signal increases from 5 mV to 32 mV with increasing the concentration of cDNA from 0.1 nM to 5 μM. In contrast, a small signal of 5 mV was recorded in the case of non-specific adsorption of fully mismatched ssDNA (5 μM). The obtained results demonstrate the potential of the MLAPS in combination with the simple and rapid LbL immobilization technique as a promising platform for the future development of multi-spot light-addressable label-free DNA chips with direct electrical readout. Y1 - 2015 U6 - https://doi.org/10.1039/C4NR07225A VL - 14 IS - 7 SP - 6143 EP - 6150 PB - Royal Society of Chemistry (RSC) CY - Cambridge ER - TY - JOUR A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred T1 - Physical response of hyperelastic models for composite materials and soft tissues JF - Asia pacific journal on computational engineering Y1 - 2015 U6 - https://doi.org/10.1186/s40540-015-0015-x SN - 2196-1166 VL - 2 IS - 3 (December 2015) SP - 1 EP - 18 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Ansmann, Gerrit A1 - Kantz, Holger T1 - Data-driven prediction and prevention of extreme events in a spatially extended excitable system JF - Physical Review E Y1 - 2015 U6 - https://doi.org/10.1103/PhysRevE.92.042910 SN - 2470-0053 VL - 92 IS - 4 SP - 042910 ER - TY - JOUR A1 - Mulhern, Colm A1 - Bialonski, Stephan A1 - Kantz, Holger T1 - Extreme events due to localization of energy JF - Physical Review E Y1 - 2015 U6 - https://doi.org/10.1103/PhysRevE.91.012918 SN - 2470-0053 VL - 91 IS - 1 SP - 012918 ER - TY - CHAP A1 - Kremers, Alexander A1 - Pieper, Martin T1 - Simulation and Verification of Bionic Heat Exchangers with COMSOL Multiphysics® Software T2 - COMSOL Conference 2015 User Presentations ; COMSOL Conference 2015 Grenoble October 14 - 16, 2015 - World Trade Center, Grenoble, France Y1 - 2015 PB - COMSOL CY - Göttingen ; Berlin ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel T1 - On an independence test approach to the goodness-of-fit problem JF - Journal of Multivariate Analysis N2 - Let X₁,…,Xₙ be independent and identically distributed random variables with distribution F. Assuming that there are measurable functions f:R²→R and g:R²→R characterizing a family F of distributions on the Borel sets of R in the way that the random variables f(X₁,X₂),g(X₁,X₂) are independent, if and only if F∈F, we propose to treat the testing problem H:F∈F,K:F∉F by applying a consistent nonparametric independence test to the bivariate sample variables (f(Xᵢ,Xⱼ),g(Xᵢ,Xⱼ)),1⩽i,j⩽n,i≠j. A parametric bootstrap procedure needed to get critical values is shown to work. The consistency of the test is discussed. The power performance of the procedure is compared with that of the classical tests of Kolmogorov–Smirnov and Cramér–von Mises in the special cases where F is the family of gamma distributions or the family of inverse Gaussian distributions. KW - Goodness-of-fit test KW - Independence test KW - Parametric bootstrap KW - Vapnik–Čhervonenkis class KW - Gamma distribution Y1 - 2015 U6 - https://doi.org/10.1016/j.jmva.2015.05.013 SN - 0047-259X VL - 2015 IS - 140 SP - 193 EP - 208 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Poghossian, Arshak A1 - Schusser, Sebastian A1 - Bäcker, Matthias A1 - Leinhos, Marcel A1 - Schöning, Michael Josef T1 - Real-time in-situ electrical monitoring of the degradation of biopolymers using semiconductor field-effect devices T2 - Biodegradable biopolymers. Vol. 1 Y1 - 2015 SN - 978-1-63483-632-6 SP - 135 EP - 153 PB - Nova Science Publ. CY - Hauppauge ER - TY - CHAP A1 - Kolditz, Melanie A1 - Albracht, Kirsten A1 - Fasse, Alessandro A1 - Albin, Thivaharan A1 - Brüggemann, Gert-Peter A1 - Abel, Dirk T1 - Evaluation of an industrial robot as a leg press training device T2 - XV International Symposium on Computer Simulation in Biomechanics July 9th – 11th 2015, Edinburgh, UK Y1 - 2015 SP - 41 EP - 42 ER - TY - CHAP A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Fasse, Alessandro A1 - Brüggemann, Gert-Peter A1 - Abel, Dirk A1 - Albracht, Kirsten T1 - Simulative Analysis of Joint Loading During Leg Press Exercise for Control Applications T2 - IFAC-PapersOnLine Y1 - 2015 U6 - https://doi.org/10.1016/j.ifacol.2015.10.179 N1 - IFAC-PapersOnLine 48-20; Conference Paper Archive VL - 48 IS - 20 SP - 435 EP - 440 ER - TY - RPRT A1 - Blandford, Daniel A1 - Dachwald, Bernd A1 - Digel, Ilya A1 - Espe, Clemens A1 - Feldmann, Marco A1 - Francke, Gero A1 - Hiecke, Hannah A1 - Kowalski, Julia A1 - Lindner, Peter A1 - Plescher, Engelbert A1 - Schöngarth, Sarah T1 - Enceladus Explorer : Schlussbericht — Version: 1.0 Y1 - 2015 U6 - https://doi.org/10.2314/GBV:86319950X N1 - Förderkennzeichen BMWi 50NA1206 PB - FH Aachen CY - Aachen ER - TY - JOUR A1 - Röth, Anjali A. A1 - Slabu, Ioana A1 - Kolvenbach, K. A1 - Engelmann, Ulrich M. A1 - Baumann, Martin A1 - Schmitz-Rode, T. A1 - Trahms, L. A1 - Neumann, U. T1 - Aufnahmekinetik von magnetischen Nanopartikeln zur Tumortherapie in humanen Pankreaskarzinomzelllinien JF - Zeitschrift für Gastroenterologie Y1 - 2015 U6 - https://doi.org/10.1055/s-0035-1559529 SN - 1439-7803 VL - 53 IS - 8 SP - KC139 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Murib, Mohammed Sharif A1 - Yeap, Weng Siang A1 - Martens, Daan A1 - Liu, Xianjie A1 - Bienstman, Peter A1 - Fahlman, M. A1 - Schöning, Michael Josef A1 - Michiels, Luc A1 - Haenen, Ken A1 - Serpengüzel, Ali A1 - Wagner, Patrick T1 - Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands JF - Sensors and actuators A: Physical N2 - In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor. Y1 - 2015 U6 - https://doi.org/10.1016/j.sna.2014.11.024 SN - 1873-3069 (E-Journal); 0924-4247 (Print) VL - 222 SP - 212 EP - 219 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Seynnes, Olivier R. A1 - Bojsen-Møller, Jens A1 - Albracht, Kirsten A1 - Arndt, Anton A1 - Cronin, Neil J. A1 - Finni, Taija A1 - Magnusson, Stig Peter T1 - Ultrasound-based testing of tendon mechanical properties: a critical evaluation JF - Journal of Applied Physiology Y1 - 2015 U6 - https://doi.org/10.1152/japplphysiol.00849.2014 SN - 8750-7587 VL - 118 IS - 2 SP - 133 EP - 141 ER - TY - CHAP A1 - Goldmann, Jan-Peter A1 - Braunstein, Bjoern A1 - Heinrich, Kai A1 - Sanno, Maximilian A1 - Stäudle, Benjamin A1 - Ritzdorf, Wolfgang A1 - Brüggemann, Gert-Peter A1 - Albracht, Kirsten T1 - Joint work of the take-off leg during elite high jump T2 - Proceedings of the 33th International Conference on Biomechanics in Sports (ISBS) Y1 - 2015 ER - TY - JOUR A1 - Huck, Christina A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Reisert, Steffen A1 - Kramer, Friederike A1 - Begoyan, Vardges K. A1 - Buniatyan, Vahe Vazgen A1 - Schöning, Michael Josef T1 - Multi-parameter sensing using high-k oxide of barium strontium titanate JF - Physica status solidi (a) N2 - High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors. In this work, a Si-based sensor chip containing Pt interdigitated electrodes covered with a thin BST layer (485 nm) has been developed for multi-parameter chemical sensing. The chip has been applied for the contactless measurement of the electrolyte conductivity, the detection of adsorbed charged macromolecules (positively charged polyelectrolytes of polyethylenimine) and the concentration of hydrogen peroxide (H2O2) vapor. The experimental results of functional testing of individual sensors are presented. The mechanism of the BST sensitivity to charged polyelectrolytes and H2O2 vapor has been proposed and discussed. Y1 - 2015 U6 - https://doi.org/10.1002/pssa.201431911 SN - 1862-6319 VL - 212 IS - 6 SP - 1259 PB - Wiley CY - Weinheim ER -