TY - JOUR A1 - Schöning, Michael Josef A1 - Brinkmann, D. A1 - Demuth, C. A1 - Poghossian, Arshak T1 - CIP (cleaning-in-place)-suitable „non-glass“ pH sensor based on a Ta2O5-gate EIS structure JF - Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale]. Y1 - 2004 SN - 88-7621-282-5 N1 - Eurosensors ; (18, 2004, Roma) SP - 857 EP - 860 CY - Roma ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Biselli, Manfred A1 - Selmer, Thorsten A1 - Öhlschläger, Peter A1 - Baumann, Marcus A1 - Förster, Arnold A1 - Poghossian, Arshak T1 - Forschung „zwischen“ den Disziplinen: das Institut für Nano- und Biotechnologien JF - Analytik news : das Online-Labormagazin für Labor und Analytik N2 - "Biologie trifft Mikroelektronik", das Motto des Instituts für Nano- und Biotechnologien (INB) an der FH Aachen, unterstreicht die zunehmende Bedeutung interdisziplinär geprägter Forschungsaktivitäten. Der thematische Zusammenschluss grundständiger Disziplinen, wie die Physik, Elektrotechnik, Chemie, Biologie sowie die Materialwissenschaften, lässt neue Forschungsgebiete entstehen, ein herausragendes Beispiel hierfür ist die Nanotechnologie: Hier werden neue Werkstoffe und Materialien entwickelt, einzelne Nanopartikel oder Moleküle und deren Wechselwirkung untersucht oder Schichtstrukturen im Nanometerbereich aufgebaut, die neue und vorher nicht bekannte Eigenschaften hervorbringen. Vor diesem Hintergrund bündelt das im Jahre 2006 gegründete INB die an der FH Aachen vorhandenen Kompetenzen von derzeit insgesamt sieben Laboratorien auf den Gebieten der Halbleitertechnik und Nanoelektronik, Nanostrukturen und DNA-Sensorik, der Chemo- und Biosensorik, der Enzymtechnologie, der Mikrobiologie und Pflanzenbiotechnologie, der Zellkulturtechnik, sowie der Roten Biotechnologie synergetisch. In der Nano- und Biotechnologie steckt außergewöhnliches Potenzial! Nicht zuletzt deshalb stellen sich die Forscher der Herausforderung, in diesem Bereich gemeinsam zu forschen und Schnittstellen zu nutzen, um so bei der Gestaltung neuartiger Ideen und Produkte mitzuwirken, die zukünftig unser alltägliches Leben verändern werden. Im Folgenden werden die verschiedenen Forschungsbereiche kurz zusammenfassend vorgestellt und vorhandene Interaktionen anhand von exemplarisch ausgewählten, aktuellen Forschungsprojekten skizziert. Y1 - 2012 VL - Publ. online PB - Dr. Beyer Internet-Beratung CY - Ober-Ramstadt ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Beckers, L. A1 - Schaub, A. A1 - Zander, W. A1 - Schubert, J. A1 - Mesters, S. A1 - Kordos, P. A1 - Lüth, H. T1 - A novel silicon-based pH sensor prepared by pulsed laser deposition technique JF - Proceedings of Eurosensors X, the 10th European Conference on Solid-State Transducers, September 8-11, 1996, Leuven, Belgium / [KU Leuven]. Puers, Robert. Vol. 3. Y1 - 1996 SN - 90-803282-1-9 N1 - Eurosensors ; (10, 1996, Louvain) Eurosensors, the European Conference on Solid-State Transducers ; (10 : ; 1996.09.08-11 : ; Leuven) SP - 781 EP - 784 PB - Catholic University Leuven CY - Heverlee, Belgium ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Arzdorf, Michael A1 - Mulchandani, P. A1 - Chen, W. A1 - Mulchandani, A. T1 - Towards a capacitive enzyme sensor for direct determination of organophosphorus pesticides: Fundamentals studies and aspects of development JF - Sensors. 3 (2003), H. 6 Y1 - 2003 SN - 1424-8220 SP - 119 EP - 127 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Arzdorf, Michael A1 - Mulchandani, P. A1 - Chen, W. A1 - Mulchandani, A. T1 - A capacitive field-effect sensor for the direct determination of organophosphorus pesticides JF - Sensors and Actuators B. 91 (2003), H. 1-3 Y1 - 2003 SN - 0925-4005 SP - 92 EP - 97 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Han, Yinhua A1 - Offenhäusser, Andreas A1 - Ingebrandt, Sven T1 - Markierungsfreie DNA-Detektion mit Silizium-Feldeffekt-Sensoren – Messeffekte oder Artefakte? JF - tm - Technisches Messen . 74 (2007), H. 9 Y1 - 2007 SN - 0171-8096 SP - 466 EP - 476 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak T1 - pH and ion sensitivity of a field-effect EIS (electrolyte-insulator-semiconductor) sensor covered with polyelectrolyte multilayers JF - Journal of Solid State Electrochemistry. 13 (2009), H. 1 Y1 - 2009 SN - 1433-0768 N1 - This manuscript is an invited paper to the special issue on “Solid-state potentiometric sensors” (Guest editor: Johan Bobacka). SP - 115 EP - 122 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Abouzar, Maryam H. A1 - Ingebrandt, Sven A1 - Platen, Johannes A1 - Offenhäusser, Andreas A1 - Poghossian, Arshak ED - Comini, Elisabetta T1 - Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices JF - Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A. Y1 - 2006 SN - 9781558998711 IS - paper 0915-R05-04 SP - 89 EP - 94 ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Silicon-based biochemical sensors JF - CNI - The Center of Nanoelectronic Systems for Information Technology Y1 - 2003 SP - 165 EP - 170 PB - Foschungszentrum Jülich ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Novel approaches to design siliconbased field-effect sensors JF - Electrochemical Microsystem Technologies, New Trends in Electrochemistry Vol. 2 Y1 - 2002 SP - 384 EP - 408 PB - Taylor & Francis CY - London New York ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Microelectronics contacts (bio-)chemistry – Semiconductor-based sensors JF - Biologi Italiani. 8 (2001) Y1 - 2001 SN - 0392-2510 SP - 5 EP - 10 ER - TY - JOUR A1 - Schöning, Michael Josef T1 - "Playing around“ with field-effect sensors on the basis of EIS structures, LAPS and ISFETs JF - Sensors. 5 (2005), H. 3 Y1 - 2005 SN - 1424-8220 SP - 126 EP - 138 ER - TY - JOUR A1 - Schöning, Michael Josef T1 - "Voltohmmetry" – a new transducer principle for electrochemical sensors JF - Ultrathin electrochemical chemo- and biosensors : technology and performance / Vladimir M. Mirsky Y1 - 2004 SN - 3-540-21285-X SP - 117 EP - 140 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Feldeffektstrukturen mit AgI-Aufdampfschichten als chemische Sensoren JF - KfK-Bericht. 5195 (1993) Y1 - 1993 SN - 0303-4003 SP - 1 EP - 95 ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Silicon recognizes biochemical parameters: Microchips for analytical sensor applications JF - American Laboratory. 32 (2000), H. 16 Y1 - 2000 SN - 0044-7749 SP - 24 EP - 31 ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Silicon-based field-effect structures – From dielectrics to bioelectronics JF - Dielectrics in emerging technologies : proceedings of the international symposium ; [papers presented at the First International Symposium on Science and Technology of Dielectrics in Emerging Fields held from 27th April to 2nd May 2003 in Paris, France] / sponsoring divisions: Dielectric Science and Technology, Electronics. Ed.: D. Misra. Y1 - 2003 SN - 1-56677-346-6 N1 - International Symposium on Science and Technology of Dielectrics in Emerging Fields ; (1, 2003, Paris) SP - 31 EP - 37 PB - Electrochemical Society CY - Pennington, NJ ER - TY - JOUR A1 - Schäfer, Horst A1 - Worschech, L. A1 - Ossau, W. A1 - Landwehr, G. T1 - Uniaxiale und planare Verspannung von Störstellenkomplexen in ZnSe/GaAs Schichten Y1 - 1997 N1 - Als Poster vorgelegt auf der Frühjahrstagung der DPG in Münster, 17.-21. März 1997, Verhandl. DPG (VI) 32, HL 11.51 / Physikalisches Institut der Universität Würzburg. ER - TY - JOUR A1 - Schäfer, Horst A1 - Worschech, L. A1 - Ossau, W. A1 - Fischer, C. T1 - Characterization of structural defects in MBE grown ZnSe JF - Materials Science and Engineering B. 43 (1997), H. 1-3 Y1 - 1997 SN - 0921-5107 N1 - Beitrag zum EMRS - Spring Meeting, 4.-7.06.1996 Strasbourg SP - 29 EP - 32 ER - TY - JOUR A1 - Schäfer, Horst A1 - Worschech, L. A1 - Fischer, C. A1 - Schenk, H. (u.a.) T1 - Linearly Polarized Luminescence associated with Structural Defects in MBE grown ZnSe JF - Blue laser and light emitting diodes : [International Symposium on Blue Laser and Light Emitting Diodes (ISBLLED), Chiba, Japan , March 5 - 7, 1996] / ed. by A. Yoshikawa Y1 - 1996 SN - 4-274-90096-7 SP - 421 EP - 424 PB - Ohmsha [u.a.] CY - Tokyo ER - TY - JOUR A1 - Schäfer, Horst A1 - Uebbing, H. A1 - von der Osten, W. A1 - Hommel, D. (u.a.) T1 - Exciton and Phonon Quantization in Ultrathin Epitaxial Layers of ZnSe JF - 23rd International Conference on the Physics of Semiconductors : Berlin, Germany, July 21 - 26, 1996 / ed.: Matthias Scheffler ... Y1 - 1996 SN - 981-02-2777-9 SP - 365 EP - 368 PB - World Scientific CY - Singapore [u.a.] ER - TY - JOUR A1 - Schäfer, Horst A1 - Uebbing, H. A1 - Stolz, H. A1 - von der Osten, W. (u.a.) T1 - Resonance Brillouin Scattering from Quantized Exciton-Polaritons in Ultrathin Epitaxial Layers of ZnSe JF - Il nuovo Cimento D. 17 (1995) Y1 - 1995 SN - 0392-6737 SP - 1753 EP - 1757 ER - TY - JOUR A1 - Schäfer, Horst A1 - Shen, J. A1 - Ossau, W. A1 - Landwehr, G. (u.a.) T1 - Optically Detected Cyclotron Resonance (ODCR) in n- and p-type GaAs/AlGaAs Heterostructures Y1 - 1995 N1 - Als Poster vorgelegt auf der Frühjahrstagung der DPG in Berlin, 20.-24. März 1995, Verhandl. DPG (VI) 30, HL 33.79 / Physikalisches Institut der Universität Würzburg. ER - TY - JOUR A1 - Schäfer, Horst A1 - Shao, Hua A1 - Scholl, W. A1 - Hommel, D. (u.a.) T1 - Quantum Corrections to Magnetotransport in n-ZnSe Grown by MBE Y1 - 1995 N1 - Als Poster vorgelegt auf der Frühjahrstagung der DPG in Berlin, 20.-24. März 1995, Verhandl. DPG (VI) 30, HL 28.76 / Physikalisches Institut der Universität Würzburg. ER - TY - JOUR A1 - Schäfer, Horst A1 - Shao, H. A1 - Scholl, H. A1 - Gerschütz, J. (u.a.) T1 - Shubnikov - de Haas Oscillations of a Two - dimensional Electron Gas in a Modulation - Doped Zn0.80Cd0.20Se/ZnS0.06Se 0.94 Single Quantum Well JF - Solid State Communications. 100 (1996), H. 11 Y1 - 1996 SN - 0038-1098 SP - 739 ER - TY - JOUR A1 - Schäfer, Horst A1 - Shao, H. A1 - Gerschütz, J. A1 - Scholl, S. (u.a.) T1 - Quantum Interference Effects in Highly Doped n-ZnSe Epitaxy Layers Grown by MBE JF - physica status solidi (b). 206 (1998), H. 2 Y1 - 1998 SN - 0370-1972 SP - 575 EP - 582 ER - TY - JOUR A1 - Schäfer, Horst A1 - Shanjia, Xu A1 - Xinzhang, Wu A1 - Boege, P. T1 - Scattering Characteristics of 3-D Discontinuity Consisting of Semiconductor Sample Filled in Waveguide with Gaps JF - International Journal of Infrared and Millimeter Waves. 14 (1993), H. 10 Y1 - 1993 SN - 0195-9271 SP - 2155 EP - 2190 ER - TY - JOUR A1 - Schäfer, Horst A1 - Scholl, S. A1 - Waag, A. A1 - Hommel, D. (u.a.) T1 - Two-dimensional Shubnikov–de Haas oscillations in modulation-doped CdTe/CdMnTe quantum-well structures JF - Applied Physics Letters. 62 (1993), H. 23 Y1 - 1993 SP - 3010 EP - 3012 ER - TY - JOUR A1 - Schäfer, Horst A1 - Scholl, S. A1 - Gerschütz, F. A1 - Fischer, F. (u.a.) T1 - Persistent Photoconductivity in Halogen-doped Cd1-X ZnX Te, Cd1-X MnX Te and Cd1-X-MgX -Te Layers JF - 22nd International Conference on the Physics of Semiconductors : Vancouver, Canada, August 15 - 19, 1994 / ed. David J. Lockwood Y1 - 1995 SN - 981-02-2021-9 SP - 2423 EP - 2426 PB - World Scientific CY - Singapore [u.a.] ER - TY - JOUR A1 - Schäfer, Horst A1 - Scholl, S. A1 - Gerschütz, F. A1 - Fischer, A. (u.a.) T1 - Persistent Photoconductivity in CdTe-based II-VI-Semiconductors JF - Solid State Communications. 91 (1994), H. 6 Y1 - 1994 SN - 0038-1098 SP - 491 EP - 495 ER - TY - JOUR A1 - Schäfer, Horst A1 - Scholl, S. A1 - Gerschütz, F. A1 - Fischer, A. T1 - Quantum Hall Effect in CdTe/Cd 1-X MgX Te Heterostructures JF - Solid State Communications. 94 (1995), H. 11 Y1 - 1995 SN - 0038-1098 SP - 935 EP - 938 ER - TY - JOUR A1 - Schäfer, Horst A1 - Ress, H. R. A1 - Spahn, W. A1 - Ebel, R. (u.a.) T1 - Start of misfit relaxation in GaAs-ZnSe heterostructures JF - Journal of Crystal Growth. 184-185 (1998) Y1 - 1998 SN - 0022-0248 SP - 90 EP - 94 ER - TY - JOUR A1 - Schäfer, Horst A1 - Ress, H. R. A1 - Spahn, W. A1 - Ebel, R. (u.a.) T1 - Hochaufgelöste Röntgenbeugung zur Untersuchung lateraler Inhomogenitäten pseudomorpher ZnSe - Schichten auf GaAs - Substraten Y1 - 1996 N1 - Als Poster vorgelegt auf der Frühjahrstagung der DPG in Regensburg, 25.-29. März 1996, Verhandl. DPG (VI) 31, HL 16.82 / Physikalisches Institut der Universität Würzburg. ER - TY - JOUR A1 - Schäfer, Horst A1 - Mende, H. H. T1 - Interaction between laminated g.o.3% SiFe sheets due to gap-stray fields and edge peaks JF - Physica Scripta. 39 (1989), H. 3 Y1 - 1989 SN - 0031-8949 SP - 397 EP - 400 ER - TY - JOUR A1 - Schäfer, Horst A1 - Mende, H. H. T1 - Simulation of stray-field coupling between stacked grain-orientedthree-percent SiFe sheets concerning domain structure and stray-fieldprofile JF - IEEE Transactions on Magnetics. 24 (1988), H. 1 Y1 - 1988 SN - 0018-9464 SP - 631 EP - 634 ER - TY - JOUR A1 - Schäfer, Horst A1 - Mende, H. H. T1 - Stray field profile of grain-oriented rectangular 3% SiFe sheets in dependence on vertical and in-plane magnetic fields JF - Physica Status Solidi (A). 100 (1987), H. 2 Y1 - 1987 SN - 0031-8965 SP - 621 EP - 632 ER - TY - JOUR A1 - Schäfer, Horst A1 - Lampey, H. A1 - Mende, H. H. T1 - Stray-field profile of single M-shaped Si-Fe transformer sheets and the resulting interaction in a stack JF - Physica Scripta. 39 (1989), H. 4 Y1 - 1989 SN - 0031-8949 SP - 520 EP - 522 ER - TY - JOUR A1 - Schäfer, Horst A1 - Lampey, H. T1 - The stray-field structure of a HI-B sheet in the vicinity of laser scratches JF - Journal of Magnetism and Magnetic Materials. 75 (1988), H. 3 Y1 - 1988 SN - 0304-8853 SP - 339 EP - 344 ER - TY - JOUR A1 - Schäfer, Horst A1 - Lampey, H. T1 - Zum Einfluß der Streufeldkopplung auf die magnetischen Eigenschaften und den Wirkungsgrad handelsüblicher Transformatorkerne aus kornorientierten Silizium-Eisen Elektroblechen JF - Electrical Engineering (Archiv fur Elektrotechnik). 72 (1989), H. 6 Y1 - 1989 SN - 0948-7921 SP - 395 EP - 405 ER - TY - JOUR A1 - Schäfer, Horst A1 - Lampey, H. T1 - Ein Beispiel zum Einfluß der Bauform auf die statische Streufeldstruktur von Elektroblechen aus Silizium-Eisen: Der M-Schnitt JF - Elektrotechnik und Informationstechnik : e & i. 106 (1989), H. 3 Y1 - 1989 SN - 0932-383X SP - 100 EP - 106 ER - TY - JOUR A1 - Schäfer, Horst A1 - Kubacki, F. A1 - Gutowski, J. A1 - Hommel, D. T1 - Effekte biaxialer und uniaxialer Verspannung auf das exzitonische Spektrum von ZnSe/ GaAs-Heterostrukturen Y1 - 1995 N1 - Als Poster vorgelegt auf der Frühjahrstagung der DPG in Berlin, 20.-24. März 1995, Verhandl. DPG (VI) 30, HL 33.38 / Physikalisches Institut der Universität Würzburg. ER - TY - JOUR A1 - Schäfer, Horst A1 - Heil, Günter T1 - Modeling and Graphic Presentation of Acid–Base Titration Curves. Presentation of an Alternative Method JF - The Chemical Educator. 7 (2002), H. 6 Y1 - 2002 SN - 1430-4171 SP - 339 EP - 346 ER - TY - JOUR A1 - Schäfer, Horst A1 - Hagelskamp, B A1 - Mende, H. H. T1 - Streufeldkopplung zwischen geschichteten Transformator-M-Schnitten aus kornorientiertem und nicht-orientiertem SiFe-Material Y1 - 1987 N1 - Als Poster vorgelegt auf der Frühjahrstagung der DPG in Münster, 9.-13. März 1987, Verhandl. DPG (VI) 22, AM-14.28 / Physikalisches Institut der Universität Würzburg. ER - TY - JOUR A1 - Schäfer, Horst A1 - Gerschütz, J. A1 - Scholl, S. A1 - Fischer, A. (u.a.) T1 - Quanten-Hall-Effekt in CdTe/Cd1-X MgX Te Heterostrukturen Y1 - 1995 N1 - Als Poster vorgelegt auf der Frühjahrstagung der DPG in Berlin, 20.-24. März 1995, Verhandl. DPG (VI) 30, HL 33.52 / Physikalisches Institut der Universität Würzburg. ER - TY - JOUR A1 - Schäfer, Horst A1 - Böttcher, A. T1 - Mapping of magnetic domain structures inside of ferromagnetic materials by X-ray topography JF - Physica Status Solidi (A). 113 (1989) Y1 - 1989 SN - 0031-8965 SP - 551 ER - TY - JOUR A1 - Schäfer, Horst A1 - Boege, P. A1 - Shanjia, Xu A1 - Xinzhang, Wu (u.a.) T1 - Improved conductivity-measurement of semiconductor epitaxial layers by means of the contactless microwave method JF - Conference digest : 10 - 14 January 1994, San Diego, California / International Conference on Millimeter and Submillimeter Waves and Applications / Mohammed N. Afsar, chair/ed. Y1 - 1994 SN - 0-8194-1558-8 N1 - Serie Proceedings / SPIE, The International Society for Optical Engineering ; 2250 SP - 649 EP - 658 PB - SPIE CY - Bellingham, Wash. ER - TY - JOUR A1 - Schäfer, Horst T1 - Zur Inhomogenität des inneren Feldes und der Flußdichte von kornorientierten Elektroblechen aus Silizium-Eisen bei Fehlorientierungen in der Blechebene JF - Electrical Engineering (Archiv fur Elektrotechnik). 72 (1989), H. 1 Y1 - 1989 SN - 0948-7921 SP - 51 EP - 57 ER - TY - JOUR A1 - Schäfer, Horst T1 - Calculation of the surface stray field and the demagnetizing field of a g.o. 3% SiFe sheet caused by a misoriented grain JF - Physica Scripta. 39 (1989), H. 4 Y1 - 1989 SN - 0031-8949 SP - 531 EP - 534 ER - TY - JOUR A1 - Schäfer, Horst T1 - Modellrechnungen und Streufeldmessung: Eine Möglichkeit zur zerstörungsfreien Kristallstruktur-Analyse von kornorientiertem Elektroblech aus Silizium-Eisen JF - Elektrotechnik und Informationstechnik : e & i. 106 (1989), H. 2 Y1 - 1989 SN - 0932-383X SP - 67 EP - 71 ER - TY - JOUR A1 - Schwabedal, Justus T. C. A1 - Sippel, Daniel A1 - Brandt, Moritz D. A1 - Bialonski, Stephan T1 - Automated Classification of Sleep Stages and EEG Artifacts in Mice with Deep Learning N2 - Sleep scoring is a necessary and time-consuming task in sleep studies. In animal models (such as mice) or in humans, automating this tedious process promises to facilitate long-term studies and to promote sleep biology as a data-driven f ield. We introduce a deep neural network model that is able to predict different states of consciousness (Wake, Non-REM, REM) in mice from EEG and EMG recordings with excellent scoring results for out-of-sample data. Predictions are made on epochs of 4 seconds length, and epochs are classified as artifactfree or not. The model architecture draws on recent advances in deep learning and in convolutional neural networks research. In contrast to previous approaches towards automated sleep scoring, our model does not rely on manually defined features of the data but learns predictive features automatically. We expect deep learning models like ours to become widely applied in different fields, automating many repetitive cognitive tasks that were previously difficult to tackle. Y1 - 2018 U6 - https://doi.org/10.48550/arXiv.1809.08443 ER - TY - JOUR A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Leinhos, Marcel A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Characterization of biodegradable polymers with capacitive field-effect sensors JF - Sensors and actuators B: Chemical N2 - In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance–voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor. KW - Impedance spectroscopy KW - C–V method KW - Real-time monitoring KW - Poly(d,l-lacticacid) KW - (Bio)degradation KW - Field-effect sensor Y1 - 2012 U6 - https://doi.org/10.1016/j.snb.2012.07.099 SN - 0925-4005 N1 - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors" VL - 187 SP - 2 EP - 7 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Krischer, M. A1 - Leinhos, Marcel A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - An application of field-effect sensors for in-situ monitoring of degradation of biopolymers JF - Sensors and actuators B: Chemical N2 - The characterization of the degradation kinetics of biodegradable polymers is mandatory with regard to their proper application. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) field-effect sensors have been applied for in-situ monitoring of the pH-dependent degradation kinetics of the commercially available biopolymer poly(d,l-lactic acid) (PDLLA) in buffer solutions from pH 3 to pH 13. PDLLA films of 500 nm thickness were deposited on the surface of an Al–p-Si–SiO2–Ta2O5 structure from a polymer solution by means of spin-coating method. The PMEIS sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. A faster degradation has been observed for PDLLA films exposed to alkaline solutions (pH 9, pH 11 and pH 13). Y1 - 2015 U6 - https://doi.org/10.1016/j.snb.2014.10.058 SN - 1873-3077 (E-Journal); 0925-4005 (Print) VL - 207, Part B SP - 954 EP - 959 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Menzel, S. A1 - Bäcker, Matthias A1 - Leinhos, Marcel A1 - Poghossian, Arshak A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Degradation of thin poly(lactic acid) films: characterization by capacitance-voltage, atomic force microscopy, scanning electron microscopy and contact-angle measurements JF - Electrochimica Acta Y1 - 2013 SN - 1873-3859 (E-Journal); 0013-4686 (Print) VL - Vol. 113 SP - 779 EP - 784 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Leinhos, Marcel A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers JF - Physica Status Solidi (A) N2 - Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution. Y1 - 2013 U6 - https://doi.org/10.1002/pssa.201200941 SN - 1521-396X ; 0031-8965 VL - 210 IS - 5 SP - 905 EP - 910 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, Maximillian A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors JF - Analytical Chemistry N2 - Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers. Y1 - 2015 U6 - https://doi.org/10.1021/acs.analchem.5b00617 SN - 1520-6882 VL - 87 IS - 13 SP - 6607 EP - 6613 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, M. A1 - Molin, D. G. M. A1 - Akker, N. M. S. van den A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation JF - Procedia Engineering N2 - A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system. Y1 - 2015 U6 - https://doi.org/10.1016/j.proeng.2015.08.815 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 948 EP - 951 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Bäcker, Matthias A1 - Krischer, M. A1 - Wenzel, L. A1 - Leinhos, Marcel A1 - Poghossian, Arshak A1 - Biselli, Manfred A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor JF - Procedia Engineering N2 - A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers. KW - Field-effect sensor KW - enzymatic (bio)degradation KW - poly(d, l-lactic acid) KW - in-situ monitoring KW - impedance spectroscopy Y1 - 2014 U6 - https://doi.org/10.1016/j.proeng.2014.11.689 SN - 1877-7058 N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014> VL - 87 SP - 1314 EP - 1317 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schubert, J. A1 - Schöning, Michael Josef A1 - Schmidt, C. A1 - Siegert, M. A1 - Mesters, S. A1 - Zander, W. A1 - Kordos, P. A1 - Lüth, H. A1 - Legin, A. A1 - Mourzina, Y. G. A1 - Seleznev, B. A1 - Vlasov, Y. G. T1 - Chalcogenide-based thin film sensors prepared by pulsed laser deposition technique JF - Applied Physics A. 69, (1999), H. Supplement 1 Y1 - 1999 SN - 0947-8396 U6 - https://doi.org/10.1007/s003390051534 SP - 803 EP - 805 ER - TY - JOUR A1 - Schubert, J. A1 - Schöning, Michael Josef A1 - Mourzina, Y. G. A1 - Legin, A. V. A1 - Vlasov, Y. G. A1 - Zander, W. A1 - Lüth, H. T1 - Multicomponent thin films for electrochemical sensor applications prepared by pulsed laser deposition JF - Sensors and Actuators B. 76 (2001), H. 1-3 Y1 - 2001 SN - 0925-4005 SP - 327 EP - 330 ER - TY - JOUR A1 - Schroth, P. A1 - Weißbecker, B. A1 - Schütz, S. A1 - Ecken, H. A1 - Yoshinobu, T. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Bioelectronic signal processing - intact chemoreceptors coupled to field-effect devices JF - Lecture Notes of the ICB Seminars Y1 - 2002 SP - 28 EP - 42 PB - MCB CY - Warsaw ER - TY - JOUR A1 - Schroth, P. A1 - Weißbecker, B. A1 - Schütz, S. A1 - Ecken, H. A1 - Yoshinobu, T. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Bioelectronic signal processing - intact chemoreceptors coupled to field-effect devices JF - Biocybernetics and Biomedical Engineering. 21 (2001), H. 3 Y1 - 2001 SN - 0208-5216 SP - 27 EP - 42 ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Schütz, S. A1 - Steffen, A. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Kordos, P. A1 - Lüth, H. T1 - Nachweis von organischen Duftstoffen durch Biosensoren auf der Basis von Insektenantennen JF - Gesellschaft Mess- und Automatisierungstechnik: Sensoren und Meßsysteme 2000 : Tagung Ludwigsburg, 13. und 14. März 2000 / VDI/VDE-Gesellschaft Meß- und Automatisierungstechnik Y1 - 2000 SN - 3-18-091530-7 N1 - VDI-Berichte; 1530 SP - 107 EP - 114 PB - VDI-Verl. CY - Düsseldorf: ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Schütz, S. A1 - Malkoc, Ü. A1 - Steffen, A. A1 - Marso, M. A1 - Hummel, Hans E. A1 - Kordos, P. A1 - Lüth, H. T1 - Coupling of insect antennae to field-effect transistors for biochemical sensing JF - Electrochimica Acta. 44 (1999), H. 21-22 Y1 - 1999 SN - 0013-4686 SP - 3821 EP - 3826 ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Schütz, S. A1 - Epanya, P. A1 - Steffen, A. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Kordos, P. A1 - Lüth, H. T1 - Improving the bioelectronic interface of an antenna/chip biosensor – technological aspects JF - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1. Y1 - 1999 SN - 90-76699-02-X N1 - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague) SP - 569 EP - 572 CY - The Hague, The Netherlands ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Schütz, S. T1 - Extending the capabilities of an antenna/chip biosensor by employing various insect species JF - Sensors and Actuators B. 78 (2001), H. 1-3 Y1 - 2001 SN - 0925-4005 SP - 1 EP - 5 ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Schütz, S. T1 - Extending the capabilities of an antenna/chip biosensor by employing various insect species JF - Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...] Y1 - 2000 SN - 87-89935-50-0 N1 - Eurosensors ; (14, 2000, København) ; Eurosensors ; (14 : ; 2000.08.27-30 : ; Copenhagen) ; European Conference on Solid-State Transducers ; (14 : ; 2000.08.27-30 : ; Copenhagen) SP - 27 EP - 30 PB - MIC, Mikroelektronik Centret CY - Lyngby, Denmark ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Kordos, P. A1 - Lüth, H. A1 - Schütz, S. A1 - Weißbecker, B. A1 - Hummel, Hans E. T1 - Insectbased BioFETs with improved signal characteristics JF - Biosensors & Bioelectronics. 14 (1999), H. 3 Y1 - 1999 SN - 0956-5663 SP - 303 EP - 308 ER - TY - JOUR A1 - Schroth, P. A1 - Lüth, H. A1 - Hummel, Hans E. A1 - Schütz, S. A1 - Schöning, Michael Josef T1 - Characterising an insect antenna as a receptor for a biosensor by means of impedance spectroscopy JF - Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz Y1 - 2001 SN - 0-08-044014-2 SP - 293 EP - 297 PB - Elsevier [u.a.] CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Scholl, Fabio A1 - Morais, Paulo A1 - Gabriel, Rayla A1 - Schöning, Michael Josef A1 - Siqueira, Jose Roberto, Jr. A1 - Caseli, Luciano T1 - Carbon nanotubes arranged as smart interfaces in lipid Langmuir-Blodgett films enhancing the enzymatic properties of penicillinase for biosensing applications JF - Applied Materials & Interfaces N2 - In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir–Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air–water interface was investigated by surface pressure–area isotherms, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy. Enzyme activity was studied with UV–vis spectroscopy and the feasibility of the supramolecular device nanostructured as ultrathin films were essayed in a capacitive electrolyte–insulator–semiconductor (EIS) sensor device. The presence of CNTs in the enzyme–lipid LB film not only tuned the catalytic activity of penicillinase but also helped conserve its enzyme activity after weeks, showing increased values of activity. Viability as penicillin sensor was demonstrated with capacitance/voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results may be related not only to the nanostructured system provided by the film, but also to the synergism between the compounds on the active layer, leading to a surface morphology that allowed a fast analyte diffusion because of an adequate molecular accommodation, which also preserved the penicillinase activity. This work therefore demonstrates the feasibility of employing LB films composed of lipids, CNTs, and enzymes as EIS devices for biosensing applications. Y1 - 2017 U6 - https://doi.org/10.1021/acsami.7b08095 SN - 1944-8252 VL - 9 IS - 36 SP - 31054 EP - 31066 PB - ACS CY - Washington ER - TY - JOUR A1 - Schoenrock, Britt A1 - Muckelt, Paul E. A1 - Hastermann, Maria A1 - Albracht, Kirsten A1 - MacGregor, Robert A1 - Martin, David A1 - Gunga, Hans-Christian A1 - Salanova, Michele A1 - Stokes, Maria J. A1 - Warner, Martin B. A1 - Blottner, Dieter T1 - Muscle stiffness indicating mission crew health in space JF - Scientific Reports N2 - Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes. KW - Ageing KW - Anatomy KW - Muscle KW - Musculoskeletal system KW - Physiology Y1 - 2024 U6 - https://doi.org/10.1038/s41598-024-54759-6 SN - 2045-2322 N1 - Corresponding author: Dieter Blottner VL - 14 IS - Article number: 4196 PB - Springer Nature CY - London ER - TY - JOUR A1 - Schneider, Jules A1 - Schwabedal, Justus T. C. A1 - Bialonski, Stephan T1 - Schlafspindeln – Funktion, Detektion und Nutzung als Biomarker für die psychiatrische Diagnostik JF - Der Nervenarzt N2 - Hintergrund: Die Schlafspindel ist ein Graphoelement des Elektroenzephalogramms (EEG), das im Leicht- und Tiefschlaf beobachtet werden kann. Veränderungen der Spindelaktivität wurden für verschiedene psychiatrische Erkrankungen beschrieben. Schlafspindeln zeigen aufgrund ihrer relativ konstanten Eigenschaften Potenzial als Biomarker in der psychiatrischen Diagnostik. Methode: Dieser Beitrag liefert einen Überblick über den Stand der Wissenschaft zu Eigenschaften und Funktionen der Schlafspindeln sowie über beschriebene Veränderungen der Spindelaktivität bei psychiatrischen Erkrankungen. Verschiedene methodische Ansätze und Ausblicke zur Spindeldetektion werden hinsichtlich deren Anwendungspotenzial in der psychiatrischen Diagnostik erläutert. Ergebnisse und Schlussfolgerung: Während Veränderungen der Spindelaktivität bei psychiatrischen Erkrankungen beschrieben wurden, ist deren exaktes Potenzial für die psychiatrische Diagnostik noch nicht ausreichend erforscht. Diesbezüglicher Erkenntnisgewinn wird in der Forschung gegenwärtig durch ressourcenintensive und fehleranfällige Methoden zur manuellen oder automatisierten Spindeldetektion ausgebremst. Neuere Detektionsansätze, die auf Deep-Learning-Verfahren basieren, könnten die Schwierigkeiten bisheriger Detektionsmethoden überwinden und damit neue Möglichkeiten für die praktisch KW - Schlafspindeldetektion KW - Psychiatrische Biomarker KW - · Psychiatrische Erkrankungen/Diagnostik KW - Elektroenzephalographie KW - Deep Learning Y1 - 2022 U6 - https://doi.org/10.1007/s00115-022-01340-z SN - 1433-0407 SP - 1 EP - 8 PB - Springer CY - Berlin, Heidelberg ER - TY - JOUR A1 - Schmitt, G. A1 - Werner, C. A1 - Schöning, Michael Josef T1 - Microelectrochemical efficiency evaluation of inhibitors for CO2 corrosion of carbon steel under high shear stress gradients JF - Corrosion 2002. Conference Proceedings. NACExpo, 57th Annual Conference and Exhibition, Denver, US, Apr 7-11, 2002 Y1 - 2002 N1 - Paper 02280 SP - 1 EP - 11 PB - NACE International CY - Houston, Texas ER - TY - JOUR A1 - Schmitt, G. A1 - Schultze, J.-W. A1 - Faßbender, F. A1 - Buß, G. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Passivation and corrosion of microelectrode arrays JF - Electrochimica Acta. 44 (1999), H. 21-22 Y1 - 1999 SN - 0013-4686 SP - 3865 EP - 3883 ER - TY - JOUR A1 - Schmitt, G. A1 - Faßbender, F. A1 - Lüth, H. A1 - Schöning, Michael Josef A1 - Schultze, J. W. A1 - Buß, G. T1 - Passivation and corrosion of microelectrode arrays JF - Materials and Corrosion. 51 (2000), H. 1 Y1 - 2000 SN - 0947-5117 SP - 20 EP - 25 ER - TY - JOUR A1 - Schmitt, G. A1 - Faßbender, F. A1 - Lüth, H. A1 - Schöning, Michael Josef A1 - Buss, G. A1 - Kranzmann, A. A1 - Gramberg, U. T1 - Korrosionsschutzwirkung von Passivierungsschichten am Beispiel eines Mikroelektrodenarrays JF - Werkstoffe für die Energietechnik / Symposium 3 Y1 - 1999 SN - 3-527-29940-8 N1 - Serie Werkstoffwoche '98 ; 3 SP - 345 EP - 350 PB - Wiley-VCH CY - Weinheim [u.a.] ER - TY - JOUR A1 - Schmidt, Daniela A1 - Langen, Karl-J. A1 - Herzog, Hans A1 - Wirths, Jochen A1 - Holschbach, Markus A1 - Kiwit, Jürgen C. W. A1 - Ziemons, Karl A1 - Coenen, Heinz-H. A1 - Müller-Gärtner, Hans-W. T1 - Whole-body kinetics and dosimetry of L-3[123I]-iodo-α-methyltyrosine JF - European Journal of Nuclear Medicine Y1 - 1997 SN - 1619-7089 VL - 24 IS - 9 SP - 1162 EP - 1166 ER - TY - JOUR A1 - Schindler, Kaspar A. A1 - Bialonski, Stephan A1 - Horstmann, Marie-Therese A1 - Elger, Christian E. A1 - Lehnertz, Klaus T1 - Evolving functional network properties and synchronizability during human epileptic seizures JF - Chaos: An Interdisciplinary Journal of Nonlinear Science Y1 - 2008 U6 - https://doi.org/10.1063/1.2966112 SN - 1089-7682 VL - 18 IS - 3 SP - 033119 ER - TY - JOUR A1 - Schieren, Mark A1 - Kleinschmidt, Joris A1 - Schmutz, Axel A1 - Loop, Torsten A1 - Gatzweiler, Karl-Heinz A1 - Staat, Manfred A1 - Wappler, Frank A1 - Defosse, Jerome T1 - Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study JF - Anaesthesia Y1 - 2019 SN - 1365-2044 U6 - https://doi.org/10.1111/anae.14815 N1 - Die Anhänge "Table S1 (Impact of sex and level of training on dental force. Results presented as median (IQR [range]) and n (%))" und "Appendix S1 (Measurement technique.)" stehen unter "Supporting Information" zum Download bereit. VL - 74 IS - 12 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Schelthoff, Christof A1 - Steffen, Bernhard A1 - Weidner, Peter A1 - Hoßfeld, Friedel T1 - Hochauflösende Modellierung von SOFC-Brennstoffzellen / Schelthoff, Christof ; Steffen, Bernhard ; Weidner, Peter ; Hoßfeld, Friedel ; Divisek, J. ; Jung, Rita JF - Mathematik : Schlüsseltechnologie für die Zukunft ; Verbundprojekte zwischen Universität und Industrie ; mit 33 Tabellen / Karl-Heinz Hoffmann ... (Hrsg.) Y1 - 1997 SN - 3-540-61677-2 N1 - auch unter der Signatur 21 TLK 446 vorhanden SP - 105 EP - 115 PB - Springer CY - Berlin ER - TY - JOUR A1 - Schelthoff, Christof A1 - Steffen, Bernhard T1 - Modellierung und Simulation am Beispiel von Hochtemperatur-Brennstoffzellen JF - Praxis der Informationsverarbeitung und Kommunikation : PIK. 19 (1996), H. 3 Y1 - 1996 SN - 0930-5157 N1 - zugleich Interner Bericht KFA-ZAM-IB-9622 unter dem gleichen Titel SP - 138 EP - 141 ER - TY - JOUR A1 - Schelthoff, Christof A1 - Basermann, Achim A1 - Reichel, Björn T1 - Preconditioned CG methods for sparse matrices on massively parallel machines / Basermann, A. ; Reichel, B. ; Schelthoff, C. JF - Parallel Computing. 23 (1997), H. 3 Y1 - 1997 SN - 0167-8191 SP - 381 EP - 398 ER - TY - JOUR A1 - Schelthoff, Christof A1 - Basermann, Achim T1 - Polynomial Preconditioning for the Conjugate Gradient Method on Massively Parallel Systems JF - Workshop über Parallelverarbeitung : Lessach (Österreich), 26.9.-30.9.1994 / Institut für Informatik, Clausthal-Zellerfeld. Klaus Ecker; Jörg Apsel Y1 - 1995 N1 - Informatik-Bericht ; 95/1 ; Workshop über Parallelverarbeitung ; <13, 1994, Lessach> SP - 150 EP - 167 PB - Inst. für Informatik CY - Clausthal-Zellerfeld ER - TY - JOUR A1 - Sawada, Kazuaki A1 - Nakazawa, Hirokazu A1 - Takenaga, Shoko A1 - Hizawa, Takeshi A1 - Futagawa, Masato A1 - Dasai, Fumihiro A1 - Sakurai, Takashi A1 - Okumura, Koichi A1 - Hattori, Toshiaki A1 - Ishida, Makoto T1 - Multimodal bioimage sensor JF - IEICE transactions on fundamentals of electronics, communidations and computer sciences N2 - To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials. Y1 - 2014 U6 - https://doi.org/10.1587/transfun.E97.A.726 SN - 0916-8508 (Print) ; 1745-1337 (Online) VL - E97-A (2014) IS - 3 SP - 726 EP - 733 PB - IEICE CY - Tokyo ER - TY - JOUR A1 - Savitskaya, I.S. A1 - Kistaubayeva, A.S. A1 - Ignatova, L.V. A1 - Digel, Ilya T1 - Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells JF - Heliyon Y1 - 2019 U6 - https://doi.org/10.1016/j.heliyon.2019.e02592 SN - 2405-8440 VL - 5 IS - 10 SP - Artikelnummer e02592 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Savitskaya, I. S. A1 - Kistaubayeva, A. S. A1 - Digel, Ilya A1 - Shokatayeva, D. H. T1 - Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials JF - Eurasian Chemico-Technological Journal Y1 - 2017 U6 - https://doi.org/10.18321/ectj670 SN - 2522-4867 VL - 19 IS - 3 SP - 255 EP - 264 ER - TY - JOUR A1 - Sander, Volker A1 - Roy, Alain T1 - GARA: A Uniform Quality of Service Architecture / Roy, Alain ; Sander, Volker JF - Grid resource management : state of the art and future trends / ed. by Jarek Nabrzyski; Jennifer M. Schopf; Jan W̜eglarz Y1 - 2004 SN - 1-4020-7575-8 N1 - International series in operations research & management science ; 64 SP - 377 EP - 394 PB - Kluwer Academic Publ. CY - Boston ER - TY - JOUR A1 - Sander, Volker A1 - Foster, Ian T. A1 - Fidler, Markus A1 - Roy, Alain T1 - End-to-end quality of service for high-end applications / Foster, Ian T. ; Fidler, Markus ; Roy, Alain ; Sander, Volker ; Winkler, Linda JF - Computer Communications. 27 (2004), H. 14 Y1 - 2004 SN - 0140-3664 SP - 1375 EP - 1388 ER - TY - JOUR A1 - Sander, Volker A1 - Foster, Ian A1 - Roy, Alain A1 - Winkler, Linda T1 - A differentiated services implementation for high-performance TCP flows JF - Computer Networks. 34 (2000), H. 6 Y1 - 2000 SN - 1389-1286 SP - 915 EP - 929 ER - TY - JOUR A1 - Sander, Volker A1 - Fidler, Markus A1 - Klimala, Wojciech T1 - Traffic shaping in aggregate-based networks: implementation and analysis / Fidler, Markus ; Sander, Volker ; Klimala, Wojciech JF - Computer Communications. 28 (2005), H. 3 Y1 - 2005 SN - 0140-3664 SP - 274 EP - 286 ER - TY - JOUR A1 - Sander, Volker A1 - Fidler, Markus T1 - A parameter based admission control for differentiated services networks / Fidler, Markus ; Sander, Volker JF - Computer Networks. 44 (2004), H. 4 Y1 - 2004 SN - 1389-1286 SP - 463 EP - 479 ER - TY - JOUR A1 - Sander, Volker A1 - Erwin, Dietmar A1 - Huber, Valentina T1 - High-performance computer management based on Java JF - Future Generation Computer Systems. 15 (1999), H. 3 Y1 - 1999 SN - 0167-739X SP - 425 EP - 432 ER - TY - JOUR A1 - Sander, Volker A1 - Czajkowski, K. A1 - Foster, I. A1 - Kesselman, C. T1 - SNAP: A Protocol for Negotiating Service Level Agreements and Coordinating Resource Management in Distributed Systems / Czajkowski, K. ; Foster, I. ; Kesselman, C. ; Sander, V. ; Tuecke, S. JF - Job Scheduling Strategies for Parallel Processing : 8th InternationalWorkshop, JSSPP 2002 Edinburgh, Scotland, UK, July 24, 2002. Revised Papers Y1 - 2002 SN - 3-540-00172-7 N1 - Lecture Notes in Computer Science ; 2537 ; JSSPP <8, 2002, Edinburgh > SP - 153 EP - 183 PB - Springer CY - Berlin ER - TY - JOUR A1 - Sagymbay, Altynay A1 - G.E., Nusupbaeva A1 - N.Zh, Tleumbetova A1 - A.S., Mutalieva A1 - Nurpeisova, Ainur A1 - D.B., Jussupova A1 - Digel, Ilya T1 - Molecular genetics features of the epidemic season 2017-2018 on the influenza in Kazakhstan JF - Eurasian Journal of Ecology Y1 - 2019 SN - 2617-7358 VL - 58 IS - 1 SP - 50 EP - 60 ER - TY - JOUR A1 - Sadykov, Rustam A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Porst, Dariusz A1 - Linder, Peter A1 - Kayser, Peter A1 - Artmann, Gerhard A1 - Savitskaya, Irina A1 - Zhubanova, Azhar T1 - Oral lead exposure induces dysbacteriosis in rats JF - Journal of Occupational Health. 51 (2009) (2009), H. 1 Y1 - 2009 SN - 1348-9585 SP - 64 EP - 73 ER - TY - JOUR A1 - Rübbelke, Dirk A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Zobel, Luzy T1 - Cross border adjustment mechanism: Initial data for the assessment of hydrogen-based steel production JF - Data in Brief N2 - Ambitious climate targets affect the competitiveness of industries in the international market. To prevent such industries from moving to other countries in the wake of increased climate protection efforts, cost adjustments may become necessary. Their design requires knowledge of country-specific production costs. Here, we present country-specific cost figures for different production routes of steel, paying particular attention to transportation costs. The data can be used in floor price models aiming to assess the competitiveness of different steel production routes in different countries (Rübbelke, 2022). KW - Energy-intensive industry KW - Steel industry KW - Competitiveness KW - Floor prices KW - Cross border adjustment mechanism Y1 - 2023 U6 - https://doi.org/10.1016/j.dib.2023.108907 SN - 2352-3409 VL - 47 IS - Article 108907 SP - 1 EP - 5 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Rübbelke, Dirk A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Zobel, Luzy T1 - Hydrogen-based steel production and global climate protection: An empirical analysis of the potential role of a European cross border adjustment mechanism JF - Journal of Cleaner Production N2 - The European Union's aim to become climate neutral by 2050 necessitates ambitious efforts to reduce carbon emissions. Large reductions can be attained particularly in energy intensive sectors like iron and steel. In order to prevent the relocation of such industries outside the EU in the course of tightening environmental regulations, the establishment of a climate club jointly with other large emitters and alternatively the unilateral implementation of an international cross-border carbon tax mechanism are proposed. This article focuses on the latter option choosing the steel sector as an example. In particular, we investigate the financial conditions under which a European cross border mechanism is capable to protect hydrogen-based steel production routes employed in Europe against more polluting competition from abroad. By using a floor price model, we assess the competitiveness of different steel production routes in selected countries. We evaluate the climate friendliness of steel production on the basis of specific GHG emissions. In addition, we utilize an input-output price model. It enables us to assess impacts of rising cost of steel production on commodities using steel as intermediates. Our results raise concerns that a cross-border tax mechanism will not suffice to bring about competitiveness of hydrogen-based steel production in Europe because the cost tends to remain higher than the cost of steel production in e.g. China. Steel is a classic example for a good used mainly as intermediate for other products. Therefore, a cross-border tax mechanism for steel will increase the price of products produced in the EU that require steel as an input. This can in turn adversely affect competitiveness of these sectors. Hence, the effects of higher steel costs on European exports should be borne in mind and could require the cross-border adjustment mechanism to also subsidize exports. Y1 - 2022 U6 - https://doi.org/10.1016/j.jclepro.2022.135040 SN - 0959-6526 VL - 380 IS - Part 2, Art. Nr.:135040 PB - Elsevier ER - TY - JOUR A1 - Röthenbacher, Annika A1 - Cesari, Matteo A1 - Doppler, Christopher E.J. A1 - Okkels, Niels A1 - Willemsen, Nele A1 - Sembowski, Nora A1 - Seger, Aline A1 - Lindner, Marie A1 - Brune, Corinna A1 - Stefani, Ambra A1 - Högl, Birgit A1 - Bialonski, Stephan A1 - Borghammer, Per A1 - Fink, Gereon R. A1 - Schober, Martin A1 - Sommerauer, Michael T1 - RBDtector: an open-source software to detect REM sleep without atonia according to visual scoring criteria JF - Scientific Reports N2 - REM sleep without atonia (RSWA) is a key feature for the diagnosis of rapid eye movement (REM) sleep behaviour disorder (RBD). We introduce RBDtector, a novel open-source software to score RSWA according to established SINBAR visual scoring criteria. We assessed muscle activity of the mentalis, flexor digitorum superficialis (FDS), and anterior tibialis (AT) muscles. RSWA was scored manually as tonic, phasic, and any activity by human scorers as well as using RBDtector in 20 subjects. Subsequently, 174 subjects (72 without RBD and 102 with RBD) were analysed with RBDtector to show the algorithm’s applicability. We additionally compared RBDtector estimates to a previously published dataset. RBDtector showed robust conformity with human scorings. The highest congruency was achieved for phasic and any activity of the FDS. Combining mentalis any and FDS any, RBDtector identified RBD subjects with 100% specificity and 96% sensitivity applying a cut-off of 20.6%. Comparable performance was obtained without manual artefact removal. RBD subjects also showed muscle bouts of higher amplitude and longer duration. RBDtector provides estimates of tonic, phasic, and any activity comparable to human scorings. RBDtector, which is freely available, can help identify RBD subjects and provides reliable RSWA metrics. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-25163-9 SN - 2045-2322 VL - 12 IS - Article number: 20886 SP - 1 EP - 14 PB - Springer Nature CY - London ER - TY - JOUR A1 - Röth, A.A. A1 - Slabu, I. A1 - Engelmann, Ulrich M. A1 - Baumann, M. A1 - Schmitz-Rode, T. A1 - Neumann, U. P. T1 - Targeting von gastroenterologischen Tumoren mittels magnetischer Nanopartikel zur hyperthermischen Therapie JF - Zeitschrift für Gastroenterologie Y1 - 2017 U6 - https://doi.org/10.1055/s-0037-1605124 VL - 55 IS - 8 SP - KV-384 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Röth, A. A1 - Slabu, I. A1 - Kolvenbach, K. A1 - Engelmann, Ulrich M. A1 - Baumann, M. A1 - Schmitz-Rode, T. A1 - Trahms, L. A1 - Neumann, U. T1 - Aufnahmekinetik von magnetischen Nanopartikeln zur Tumortherapie in humanen Pankreaskarzinomzelllinien JF - Zeitschrift für Gastroenterologie Y1 - 2015 U6 - https://doi.org/10.1055/s-0035-1559529 SN - 1439-7803 VL - 53 IS - 8 SP - KC139 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Schöning, Michael Josef A1 - Selmer, Thorsten T1 - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid JF - Applied Biochemistry and Biotechnology N2 - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates. Y1 - 2017 U6 - https://doi.org/10.1007/s12010-017-2578-1 SN - 1559-0291 VL - 183 SP - 566 EP - 581 PB - Springer CY - Berlin ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Dahmen, Markus A1 - Keusgen, Michael A1 - Selmer, Thorsten A1 - Schöning, Michael Josef T1 - Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes JF - Frontiers in Chemistry N2 - Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes. Y1 - 2018 U6 - https://doi.org/10.3389/fchem.2018.00284 IS - 6 PB - Frontiers CY - Lausanne ER -