TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, W.
T1  - Solar Sails for Near- and Medium-Term Scientific Deep Space Missions / W. Sebolt ; B. Dachwald
JF  - In-space propulsion : edited book of proceedings of the 10-IWCP, the 10th International Workshop on Combustion and Propulsion held in Lerici, La Spezia, Italy, 21-25 September 2003 / [ed.: Luigi T. DeLuca]
Y1  - 2005
N1  - Paper 31 ; International workshop on combustion and propulsion <10, 2003, Lerici>
PB  - SP Lab, Politecnico di Milano
CY  - Milano
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, W.
T1  - Solar Sails — Propellantless Propulsion for Near- and Medium-Term Deep-Space Missions  / W. Seboldt ; B. Dachwald
JF  - Advanced Propulsion Systems and Technologies, Today to 2020 / Claudio Bruno (ed.) ... - (Progress in Astronautics and Aeronautics Series ; 223)
Y1  - 2008
SN  - 978-1-56347-929-8
N1  - ISBN 10: 1-56347-929-X  ; American Institute of Aeronautics and Astronautics <New York, NY>
PB  - AIAA
CY  - Reston, Va.
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, W.
A1  - Loeb, H. W
A1  - Schartner, K.-H.
T1  - Main Belt Asteroid Sample Return Mission Using Solar Electric Propulsion
JF  - Acta Astronautica. 63 (2008), H. 1-4
Y1  - 2008
SN  - 0094-5765
N1  - International Astronautical Federation Congress <58, 2007, Hyderabad> ; International Astronautical Congress <58, 2007, Hyderabad> ; IAC-07-A3.5.07
SP  - 91
EP  - 101
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, W.
A1  - Lämmerzahl, W.
T1  - Solar Sail Propulsion: An Enabling Technology for Fundamental Physics Missions
JF  - Lasers, Clocks and Drag Free Control : Exploration of Relativistic Gravity in Space / by Hansjörg Dittus ..., eds. - ( Astrophysics and Space Science Library ; 349)
Y1  - 2008
SN  - 978-3-540-34376-9
SP  - 379
EP  - 398
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, W.
A1  - Richter, L.
T1  - Multiple rendezvous and sample return missions to near-Earth objects using solar sailcraft / Dachwald, B. ; Seboldt, W. ; Richter, L.
JF  - Acta Astronautica. 59 (2006), H. 8-11
Y1  - 2006
SN  - 0094-5765
N1  - International Conference on Low Cost Planetary Missions <5, 2003, Noordwijk> ; Selected Proceedings
SP  - 768
EP  - 776
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, W.
A1  - Richter, L.
T1  - Multiple Rendezvous and Sample Return Missions to Near-Earth Asteroids Using Solar Sailcraft
JF  - Proceedings of the Fifth IAA International Conference on Low Cost Planetary Missions : 24 - 26 September 2003, ESTEC, Noordwijk, the Netherlands / [comp. by R. A. Harris]
Y1  - 2003
SN  - 92-9092-853-0
N1  - International Conference on Low Cost Planetary Missions <5, 2003, Noordwijk> ; International Academy of Astronautics ; European Space Research and Technology Centre
SP  - 351
EP  - 358
PB  - ESA
CY  - Noordwijk
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, Wolfgang
T1  - Solar sailcraft of the first generation technology development / Seboldt, Wolfgang ; Dachwald, Bernd
Y1  - 2003
N1  - 54th International Astronautical Congress of the International Astronautical Federation, the International Academy of Astronautics, and the International Institute of Space Law 29 September - 3 October 2003, Bremen, Germany IAC-03-S.03
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, Wolfgang
T1  - Solar sailcraft of the first generation mission applications to near-earth asteroids
Y1  - 2003
N1  - 54th International Astronautical Congress of the International Astronautical Federation, the International Academy of Astronautics, and the International Institute of Space Law 29 September - 3 October 2003, Bremen, Germany IAC-03-Q.5.06
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, Wolfgang
A1  - Macdonald, Malcolm
A1  - Mengali, Giovanni
A1  - Quatra, Alessandro A.
A1  - McInnes, Colin R.
A1  - Rios-Reyes, Leonel
A1  - Scheerers, Daniel J.
A1  - Wie, Bong
A1  - Görlich, Marianne
A1  - Lura, Franz
A1  - Diedrich, Benjamin
A1  - Baturkin, Volodymyr
A1  - Coverstone, Victoria L.
A1  - Leipold, Manfred
A1  - Garbe, Gregory P.
T1  - Potential Solar Sail Degradation Effects on Trajectory and Attitude Control
JF  - AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)
Y1  - 2005
SN  - 1-56347-765-3
N1  - American Institute of Aeronautics and Astronautics <Reston, Va.> ; AIAA Guidance, Navigation, and Control Conference and Exhibit <2005, San Francisco, Calif.> ; AIAA paper number: AIAA-2006-6172
Link "<a href="https://arc.aiaa.org/doi/book/10.2514/MGNC05"_blank">https://arc.aiaa.org/doi/book/10.2514/MGNC05</a>" am 15.07.2022 nachgetragen Behr
PB  - American Institute of Aeronautics and Astronautics
CY  - Reston, Va.
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Turyshev, Slava G.
A1  - Dittus, H.
A1  - Shao, M. [u.a.]
T1  - Fundamental Physics with the Laser Astrometric Test Of Relativity / S.G. Turyshev ;  H. Dittus ; M. Shao ... B.Dachwald ...
JF  - Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)
Y1  - 2005
SN  - 9290928999
N1  - ISBN der CD-ROM-Ausg.: 9290928999 ; Symposium Trends in Space Science and Cosmic Vision 2020 <2005, Noordwijk> ; ESLAB symposium <39, 2005, Noordwijk> ; European Space Laboratory
SP  - 8
EP  - 11
PB  - ESA Publ. Div.
CY  - Noordwijk
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Ulamec, Stephan
A1  - Postberg, Frank
A1  - Sohl, Frank
A1  - Vera, Jean-Pierre de
A1  - Christoph, Waldmann
A1  - Lorenz, Ralph D.
A1  - Hellard, Hugo
A1  - Biele, Jens
A1  - Rettberg, Petra
T1  - Key technologies and instrumentation for subsurface exploration of ocean worlds
JF  - Space Science Reviews
N2  - In this chapter, the key technologies and the instrumentation required for the subsurface exploration of ocean worlds are discussed. The focus is laid on Jupiter’s moon Europa and Saturn’s moon Enceladus because they have the highest potential for such missions in the near future. The exploration of their oceans requires landing on the surface, penetrating the thick ice shell with an ice-penetrating probe, and probably diving with an underwater vehicle through dozens of kilometers of water to the ocean floor, to have the chance to find life, if it exists. Technologically, such missions are extremely challenging. The required key technologies include power generation, communications, pressure resistance, radiation hardness, corrosion protection, navigation, miniaturization, autonomy, and sterilization and cleaning. Simpler mission concepts involve impactors and penetrators or – in the case of Enceladus – plume-fly-through missions.
Y1  - 2020
U6  - http://dx.doi.org/10.1007/s11214-020-00707-5
SN  - 1572-9672
N1  - Corresponding author: Bernd Dachwald
VL  - 216
IS  - Art. 83
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Wi, Bong
T1  - Solar Sail Kinetic Energy Impactor Trajectory Optimization for an Asteroid-Deflection Mission
JF  - Journal of Spacecraft and Rockets. 44 (2007), H. 4
Y1  - 2007
SN  - 0022-4650
N1  - 2. ISSN: 1533-6794
SP  - 755
EP  - 764
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Wie, Bong
T1  - Solar Sail Trajectory Optimization for Intercepting, Impacting, and Deflecting Near-Earth Asteroids
JF  - AIAA Guidance, Navigation and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : [San Francisco, California, 15 - 18 August 2005 ; papers]. - (AIAA meeting papers on disc ; [10.]2005,16-17)
Y1  - 2005
SN  - 1-56347-765-3
N1  - American Institute of Aeronautics and Astronautics <Reston, Va.> ; AIAA Guidance, Navigation, and Control Conference and Exhibit <2005, San Francisco, Calif.> ; AIAA paper number: AIAA-2006-6176
PB  - American Institute of Aeronautics and Astronautics
CY  - Reston, Va.
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Wurm, Patrick
T1  - Mission analysis and performance comparison for an Advanced Solar Photon Thruster
JF  - Advances in Space Research
Y1  - 2011
SN  - 0273-1177
VL  - 48
IS  - 11
SP  - 1858
EP  - 1868
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dashevsky, Alexey V.
A1  - Lanzl, Ines M.
A1  - Kotliar, Konstantin
T1  - Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal
JF  - Graefe's Archive for Clinical and Experimental Ophthalmology
Y1  - 2011
SN  - 0721-832x
VL  - 249
IS  - 4
SP  - 565
EP  - 573
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Defosse, Jerome
A1  - Kleinschmidt, Joris
A1  - Schmutz, Axel
A1  - Loop, Torsten
A1  - Staat, Manfred
A1  - Gatzweiler, Karl-Heinz
A1  - Wappler, Frank
A1  - Schieren, Mark
T1  - Dental strain on maxillary incisors during tracheal intubation with double-lumen tubes and different laryngoscopy techniques - a blinded manikin study
JF  - Journal of Cardiothoracic and Vascular Anesthesia
KW  - anaesthetic complications
KW  - dental trauma
KW  - difficult airway
KW  - double-lumen tube intubation
KW  - videolaryngoscopy
Y1  - 2022
U6  - http://dx.doi.org/10.1053/j.jvca.2022.02.017
SN  - 1053-0770
VL  - 36
IS  - 8, Part B
SP  - 3021
EP  - 3027
PB  - Elsevier
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Demirci, T.
A1  - Trzewik, J.
A1  - Linder, Peter
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison
JF  - Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1046
EP  - 1047
ER  - 
TY  - JOUR
A1  - Demirci, T.
A1  - Trzewik, J.
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level
JF  - Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1030
EP  - 1031
ER  - 
TY  - JOUR
A1  - Demirci, Taylan
A1  - Kurulgan Demirci, Eylem
A1  - Trzewik, Jürgen
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Sakizli, Meral
A1  - Temiz Artmann, Aysegül
T1  - Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress
JF  - IUBMB Life. 61 (2009), H. 3
Y1  - 2009
SN  - 1521-6543
N1  - Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5-8, 2009, Istanbul, Turkey
SP  - 311
EP  - 312
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Digel, Ilya
T1  - Primary thermosensory events in cells
JF  - Transient receptor potential channels / Md. Shahidul Islam, ed.
Y1  - 2011
SN  - 978-94-007-0264-6
N1  - (Advances in experimental medicine and biology ; 704)
SP  - 451
EP  - 468
PB  - Springer
CY  - Dordrecht [u.a.]
ER  - 
TY  - JOUR
A1  - Digel, Ilya
T1  - Controlling microbial adhesion : a surface engineering approach
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 601
EP  - 625
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Digel, Ilya
T1  - In-situ biological decontamination of an ice melting probe
Y1  - 2010
N1  - 38th COSPAR Scientific Assembly. Held 18-15 July 2010, in Bremen, Germany
Abstract unter https://www.cospar-assembly.org/abstractcd/OLD/COSPAR-10/abstracts/data/pdf/abstracts/F36-0013-10.pdf
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Akimbekov, N.
A1  - Turalieva, M.
A1  - Mansurov, Z.
A1  - Temiz Artmann, Aysegül
A1  - Eshibaev, A.
A1  - Zhubanova, A.
T1  - Usage of Carbonized Plant Wastes for Purification of Aqueous Solutions
JF  - Journal of Industrial Technology and Engineering
Y1  - 2013
VL  - 2
IS  - 07
SP  - 47
EP  - 54
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Akimbekov, Nuraly
A1  - Rogachev, Evgeniy
A1  - Pogorelova, Natalia
T1  - Bacterial cellulose produced by Medusomyces gisevii on glucose and sucrose: biosynthesis and structural properties
JF  - Cellulose
N2  - In this work, the effects of carbon sources and culture media on the production and structural properties of bacterial cellulose (BC) synthesized by Medusomyces gisevii have been studied. The culture medium was composed of different initial concentrations of glucose or sucrose dissolved in 0.4% extract of plain green tea. Parameters of the culture media (titratable acidity, substrate conversion degree etc.) were monitored daily for 20 days of cultivation. The BC pellicles produced on different carbon sources were characterized in terms of biomass yield, crystallinity and morphology by field emission scanning electron microscopy (FE-SEM), atomic force microscopy and X-ray diffraction. Our results showed that Medusomyces gisevii had higher BC yields in media with sugar concentrations close to 10 g L−1 after a 18–20 days incubation period. Glucose in general lead to a higher BC yield (173 g L−1) compared to sucrose (163.5 g L−1). The BC crystallinity degree and surface roughness were higher in the samples synthetized from sucrose. Obtained FE-SEM micrographs show that the BC pellicles synthesized in the sucrose media contained densely packed tangles of cellulose fibrils whereas the BC produced in the glucose media displayed rather linear geometry of the BC fibrils without noticeable aggregates.
KW  - Bacterial cellulose
KW  - Medusomyces gisevi
KW  - Carbon sources
KW  - Culture media
KW  - Cellulose nanostructure
Y1  - 2023
U6  - http://dx.doi.org/10.1007/s10570-023-05592-z
SN  - 1572-882X (Online)
SN  - 0969-0239 (Print)
N1  - Corresponding author: Ilya Digel
PB  - Springer Science + Business Media
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Dachwald, Bernd
A1  - Artmann, Gerhard
A1  - Linder, Peter
A1  - Funke, O.
T1  - A concept of a probe for particle analysis and life detection in icy environments
Y1  - 2009
N1  - International workshop “Europa lander: science goals and experiments”, Space Research Institute (IKI), Moscow, Russia
9-13 February 2009
SP  - 1
EP  - 24
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Demirci, Taylan
A1  - Temiz Artmann, Aysegül
A1  - Nishikawa, K.
T1  - Free Radical Nature of the Bactericidal Effect of Plasma-Generated Cluster Ions (PCIs)
JF  - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 982
EP  - 983
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Kayser, Peter
A1  - Artmann, Gerhard
T1  - Molecular processes in biological thermosensation
JF  - Journal of Biophysics. 2008 (2008)
Y1  - 2008
SN  - 1687-8000
SP  - 1
EP  - 9
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Kern, Inna
A1  - Geenen, Eva-Maria
A1  - Akimbekov, Nuraly
T1  - Dental plaque removal by ultrasonic toothbrushes
JF  - dentistry journal
N2  - With the variety of toothbrushes on the market, the question arises, which toothbrush is best suited to maintain oral health? This thematic review focuses first on plaque formation mechanisms and then on the plaque removal effectiveness of ultrasonic toothbrushes and their potential in preventing oral diseases like periodontitis, gingivitis, and caries. We overviewed the physical effects that occurred during brushing and tried to address the question of whether ultrasonic toothbrushes effectively reduced the microbial burden by increasing the hydrodynamic forces. The results of published studies show that electric toothbrushes, which combine ultrasonic and sonic (or acoustic and mechanic) actions, may have the most promising effect on good oral health. Existing ultrasonic/sonic toothbrush models do not significantly differ regarding the removal of dental biofilm and the reduction of gingival inflammation compared with other electrically powered toothbrushes, whereas the manual toothbrushes show a lower effectiveness.
Y1  - 2020
U6  - http://dx.doi.org/10.3390/dj8010028
SN  - 2304-6767
VL  - 8
IS  - 28
SP  - 1
EP  - 13
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Kurulgan Demirci, Eylem
A1  - Linder, Peter
A1  - Kayser, Peter
T1  - Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts
JF  - Medical and Biological Engineering and Computing. 45 (2007), H. 1
Y1  - 2007
SN  - 1741-0444
SP  - 91
EP  - 97
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Maggakis-Kelemen, Christina
A1  - Zerlin, Kay
A1  - Linder, Peter
T1  - Body temperature-related structural transitions of monotremal and human hemoglobin
JF  - Biophysical Journal. 91 (2006), H. 8
Y1  - 2006
SN  - 1542-0086
SP  - 3014
EP  - 3021
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - The emperor's new body : seeking for a blueprint of limb regeneration in humans
JF  - Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.
Y1  - 2011
SN  - 978-3-642-11864-7
SP  - 3
EP  - 37
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nishikawa, K.
A1  - Artmann, Gerhard
T1  - Cluster air-ion effects on bacteria and moulds
JF  - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1040
EP  - 1041
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nishikawa, K.
A1  - Cook, M.
T1  - Bactericidal effects of plasma-generated cluster ions
JF  - Medical and Biological Engineering and Computing. 43 (2005), H. 6
Y1  - 2005
SN  - 1741-0444
SP  - 800
EP  - 807
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Trzewik, Jürgen
A1  - Demirci, Taylan
A1  - Temiz Artmann, Aysegül
T1  - Response of fibroblasts to cyclic mechanical stress : a proteome approach / Digel, I. ; Trzewik, J. ; Demirci, T. ; Temiz Artmann, A. ; Artmann, G. M.
JF  - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1042
EP  - 1043
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Wehlitz, V.
A1  - Kayser, Peter
A1  - Figiel-Lange, A.
A1  - Bassam, R.
A1  - Rundstedt, F. von
T1  - Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids
JF  - Plant Pathology
N2  - Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel ‘suspension depletion’ approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10–12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach.
Y1  - 2018
U6  - http://dx.doi.org/10.1111/ppa.12750
SN  - 1365-3059
VL  - 67
IS  - 2
SP  - 358
EP  - 365
PB  - Wiley
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Zerlin, Kay
A1  - Temiz Artmann, Aysegül
A1  - Engels, S.
T1  - Protein dynamics in thermosensation
JF  - Regenerative medicine. 2 (2007), H. 5
Y1  - 2007
SN  - 1746-0751
N1  - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany
SP  - 533
EP  - 533
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Zhubanova, Azhar A.
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology
JF  - Biotechnologija : teorija i praktika (2004)
Y1  - 2004
SN  - 1028-9399
SP  - 46
EP  - 52
ER  - 
TY  - JOUR
A1  - Dittus, H.
A1  - Turyshev, S. G.
A1  - Dachwald, Bernd
A1  - Blome, Hans-Joachim
T1  - A Mission to Explore the Pioneer Anomaly
JF  - Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)
Y1  - 2005
SN  - 9290928999
N1  - ISBN der CD-ROM-Ausg.: 9290928999 ; Symposium Trends in Space Science and Cosmic Vision 2020 <2005, Noordwijk> ; ESLAB symposium <39,2005, Noordwijk> ; European Space Laboratory ; Report Number: LA-UR-05-4907 ; The Pioneer Explorer Collaboration
SP  - 3
EP  - 10
PB  - ESA Publ. Div.
CY  - Noordwijk
ER  - 
TY  - JOUR
A1  - Doorschodt, B. M.
A1  - Schreinemachers, M. C. J. M.
A1  - Behbahani, Mehdi
A1  - Florquin, S.
A1  - Weis, J.
A1  - Staat, Manfred
A1  - Tolba, R. H.
T1  - Hypothermic machine perfusion of kidney grafts: which pressure is preferred
JF  - Annals of Biomedical Engineering. 39 (2011), H. 3
Y1  - 2011
SN  - 1573-9686
SP  - 1051
EP  - 1059
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Staat, Manfred
T1  - Physical response of hyperelastic models for composite materials and soft tissues
JF  - Asia pacific journal on computational engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1186/s40540-015-0015-x
SN  - 2196-1166
VL  - 2
IS  - 3 (December 2015)
SP  - 1
EP  - 18
ER  - 
TY  - JOUR
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Tran, Thanh Ngoc
A1  - Tolba, R. H.
A1  - Staat, Manfred
T1  - Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen
JF  - International biomechanics
Y1  - 2015
U6  - http://dx.doi.org/10.1080/23335432.2015.1049295
SN  - 2333-5432
VL  - Vol. 2
IS  - Iss. 1
SP  - 79
EP  - 88
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Eijck, Lambert van
A1  - Demmel, Franz
A1  - Artmann, Gerhard
A1  - Stadtler, Andreas Maximilian
T1  - Macromolecular dynamics in red blood cells investigated using neutron spectroscopy
JF  - Journal of the Royal Society Interface
Y1  - 2011
SN  - 1742-5689
VL  - 8
IS  - 57
SP  - 590
EP  - 600
PB  - The Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Erbayraktar, Zubeyde
A1  - Yilmaz, Osman
A1  - Temiz Artmann, Aysegül
A1  - Cehreli, Ruksan
A1  - Coker, Canan
T1  - Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus
JF  - Biological Trace Element Research
Y1  - 2007
SN  - 1559-0720
VL  - 118
IS  - 3
SP  - 217
EP  - 226
ER  - 
TY  - JOUR
A1  - Feucht, Nikolaus
A1  - Schönbach, Etienne Michael
A1  - Lanzl, Ines
A1  - Kotliar, Konstantin
A1  - Lohmann, Chris Patrick
A1  - Maier, Mathias
T1  - Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease
JF  - Clinical Ophthalmology
Y1  - 2013
SN  - 1177-5483
VL  - 7
SP  - 173
EP  - 178
PB  - Dove Medical Press
CY  - Auckland, New Zealand
ER  - 
TY  - JOUR
A1  - Frotscher, Ralf
A1  - Koch, Jan-Peter
A1  - Staat, Manfred
T1  - Computational investigation of drug action on human-induced stem cell derived cardiomyocytes
JF  - Journal of biomechanical engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1115/1.4030173
SN  - 1528-8951 (E-Journal); 0148-0731 (Print)
VL  - Vol. 137
IS  - iss. 7
SP  - 071002-1
EP  - 071002-7
PB  - ASME
CY  - New York
ER  - 
TY  - JOUR
A1  - Frotscher, Ralf
A1  - Muanghong, Danita
A1  - Dursun, Gözde
A1  - Goßmann, Matthias
A1  - Temiz Artmann, Aysegül
A1  - Staat, Manfred
T1  - Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue
JF  - Journal of Biomechanics
N2  - We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.
KW  - hiPS cardiomyocytes
KW  - Homogenization
KW  - Hodgkin–Huxley models
KW  - Frequency adaption
KW  - Electromechanical modeling
KW  - Drug simulation
KW  - Computational biomechanics
KW  - Cardiac tissue
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.jbiomech.2016.01.039
SN  - 0021-9290 (Print)
SN  - 1873-2380 (Online)
VL  - 49
IS  - 12
SP  - 2428
EP  - 2435
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Frotscher, Ralf
A1  - Staat, Manfred
T1  - Stresses produced by different textile mesh implants in a tissue equivalent
JF  - BioNanoMaterials
N2  - Two single-incision mini-slings used for treating urinary incontinence in women are compared with respect to the stresses they produce in their surrounding tissue. In an earlier paper we experimentally observed that these implants produce considerably different stress distributions in a muscle tissue equivalent. Here we perform 2D finite element analyses to compare the shear stresses and normal stresses in the tissue equivalent for the two meshes and to investigate their failure behavior. The results clearly show that the Gynecare TVT fails for increasing loads in a zipper-like manner because it gradually debonds from the surrounding tissue. Contrary to that, the tissue at the ends of the DynaMesh-SIS direct may rupture but only at higher loads. The simulation results are in good agreement with the experimental observations thus the computational model helps to interpret the experimental results and provides a tool for qualitative evaluation of mesh implants.
Y1  - 2014
U6  - http://dx.doi.org/10.1515/bnm-2014-0003
SN  - 2191-4672 (E-Journal); 2193-066X (E-Journal); 0011-8656 (Print); 1616-0177 (Print); 2193-0651 (Print)
VL  - 15
IS  - 1-2
SP  - 25
EP  - 30
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Fuest, Matthias
A1  - Kotliar, Konstantin
A1  - Walter, Peter
A1  - Plange, Niklas
T1  - Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry
JF  - Ophthalmic and physiological optics
Y1  - 2014
U6  - http://dx.doi.org/10.1111/opo.12134
SN  - 1475-1313 (E-Journal); 0275-5408 (Print)
N1  - Special Issue: The Ageing Visual System
VL  - 34
IS  - 4
SP  - 438
EP  - 444
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Garhofer, Gerhard
A1  - Bek, Toke
A1  - Boehm, Andreas G.
A1  - Gherghel, Doina
A1  - Grundwald, Juan
A1  - Jeppesen, Peter
A1  - Kergoat, Hélène
A1  - Kotliar, Konstantin
A1  - Lanzl, Ines
A1  - Lovasik, John V.
A1  - Nagel, Edgar
A1  - Vilser, Walthard
A1  - Orgul, Selim
A1  - Schmetterer, Leopold
T1  - Use of the retinal vessel analyzer in ocular blood flow research
JF  - Acta Ophthalmol
N2  - The present article describes a standard instrument for the continuous online determination of retinal vessel diameters, the commercially available retinal vessel analyzer. This report is intended to provide informed guidelines for measuring ocular blood flow with this system. The report describes the principles underlying the method and the instruments currently available, and discusses clinical protocol and the specific parameters measured by the system. Unresolved questions and the possible limitations of the technique are also discussed.
Y1  - 2010
U6  - http://dx.doi.org/10.1111/j.1755-3768.2009.01587.x
SN  - 1755-3768
VL  - 88
IS  - 7
SP  - 717
EP  - 722
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - German, Laura
A1  - Mikucki, Jill A.
A1  - Welch, Susan A.
A1  - Welch, Kathleen A.
A1  - Lutton, Anthony
A1  - Dachwald, Bernd
A1  - Kowalski, Julia
A1  - Heinen, Dirk
A1  - Feldmann, Marco
A1  - Francke, Gero
A1  - Espe, Clemens
A1  - Lyons, W. Berry
T1  - Validation of sampling antarctic subglacial hypersaline waters with an electrothermal ice melting probe (IceMole) for environmental analytical geochemistry
JF  - International Journal of Environmental Analytical Chemistry
N2  - Geochemical characterisation of hypersaline waters is difficult as high concentrations of salts hinder the analysis of constituents at low concentrations, such as trace metals, and the collection of samples for trace metal analysis in natural waters can be easily contaminated. This is particularly the case if samples are collected by non-conventional techniques such as those required for aquatic subglacial environments. In this paper we present the first analysis of a subglacial brine from Taylor Valley, (~ 78°S), Antarctica for the trace metals: Ba, Co, Mo, Rb, Sr, V, and U. Samples were collected englacially using an electrothermal melting probe called the IceMole. This probe uses differential heating of a copper head as well as the probe’s sidewalls and an ice screw at the melting head to move through glacier ice. Detailed blanks, meltwater, and subglacial brine samples were collected to evaluate the impact of the IceMole and the borehole pump, the melting and collection process, filtration, and storage on the geochemistry of the samples collected by this device. Comparisons between melt water profiles through the glacier ice and blank analysis, with published studies on ice geochemistry, suggest the potential for minor contributions of some species Rb, As, Co, Mn, Ni, NH4+, and NO2−+NO3− from the IceMole. The ability to conduct detailed chemical analyses of subglacial fluids collected with melting probes is critical for the future exploration of the hundreds of deep subglacial lakes in Antarctica.
Y1  - 2021
U6  - http://dx.doi.org/10.1080/03067319.2019.1704750
SN  - 0306-7319
VL  - 101
IS  - 15
SP  - 2654
EP  - 2667
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Gossmann, Matthias
A1  - Thomas, Ulrich
A1  - Horváth, András
A1  - Dragicevic, Elena
A1  - Stoelzle-Feix, Sonja
A1  - Jung, Alexander
A1  - Raman, Aravind Hariharan
A1  - Staat, Manfred
A1  - Linder, Peter
T1  - A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions
JF  - Journal of Pharmacological and Toxicological Methods
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.vascn.2020.106843
VL  - 105
IS  - Article 106843
PB  - Elsevier
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Goßmann, Matthias
A1  - Frotscher, Ralf
A1  - Linder, Peter
A1  - Bayer, Robin
A1  - Epple, U.
A1  - Staat, Manfred
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells
JF  - Cellular physiology and biochemistry
N2  - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.
KW  - Inotropic compounds
KW  - Pharmacology
KW  - Ion channels
KW  - CellDrum
KW  - Heart tissue culture
KW  - Induced pluripotent stem cells
KW  - Cardiac myocytes
Y1  - 2016
U6  - http://dx.doi.org/10.1159/000443124
SN  - 1421-9778 (Online)
SN  - 1015-8987 (Print)
VL  - 38
IS  - 3
SP  - 1182
EP  - 1198
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Grottke, O.
A1  - Braunschweig, T.
A1  - Philippen, B.
A1  - Gatzweiler, Karl-Heinz
A1  - Gronloh, N.
A1  - Staat, Manfred
A1  - Rossaint, R.
A1  - Tolba, R.
T1  - A New Model for Blunt Liver Injuries in the Swine
JF  - European Surgical Research. 44 (2010), H. 2
Y1  - 2010
SN  - 1421-9921
SP  - 65
EP  - 73
ER  - 
TY  - JOUR
A1  - Grundmann, Jan Thimo
A1  - Dachwald, Bernd
A1  - Grimm, Christian D.
A1  - Kahle, Ralph
A1  - Koch, Aaron Dexter
A1  - Krause, Christian
A1  - Lange, Caroline
A1  - Quantius, Dominik
A1  - Ulamec, Stephan
T1  - Spacecraft for Hypervelocity Impact Research – An Overview of Capabilities, Constraints and the Challenges of Getting There
JF  - Procedia Engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.04.021
SN  - 1877-7058
N1  - Proceedings of the 2015 Hypervelocity Impact Symposium (HVIS 2015)
VL  - Vol. 103
SP  - 151
EP  - 158
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hackl, M.
A1  - Andermahr, J.
A1  - Staat, Manfred
A1  - Bremer, I.
A1  - Borggrefe, J.
A1  - Prescher, A.
A1  - Müller, L. P.
A1  - Wegmann, K.
T1  - Suture button reconstruction of the central band of the interosseous membrane in Essex-Lopresti lesions: a comparative biomechanical investigation
JF  - The Journal of Hand Surgery (European Volume)
Y1  - 2017
U6  - http://dx.doi.org/10.1177/1753193416665943
SN  - 2043-6289 (Online)
SN  - 1753-1934 (Print)
VL  - 42
IS  - 4
SP  - 370
EP  - 376
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Buess, Eduard
A1  - Kammerlohr, Sandra
A1  - Nacov, Julia
A1  - Staat, Manfred
A1  - Leschinger, Tim
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - A "comma sign"-directed subscapularis repair in anterosuperior rotator cuff tears yields biomechanical advantages in a cadaveric model
JF  - The american journal of sports medicine
N2  - Background:
Additional stabilization of the “comma sign” in anterosuperior rotator cuff repair has been proposed to provide biomechanical benefits regarding stability of the repair.
Purpose:
This in vitro investigation aimed to investigate the influence of a comma sign–directed reconstruction technique for anterosuperior rotator cuff tears on the primary stability of the subscapularis tendon repair.
Study Design:
Controlled laboratory study.
Methods:
A total of 18 fresh-frozen cadaveric shoulders were used in this study. Anterosuperior rotator cuff tears (complete full-thickness tear of the supraspinatus and subscapularis tendons) were created, and supraspinatus repair was performed with a standard suture bridge technique. The subscapularis was repaired with either a (1) single-row or (2) comma sign technique. A high-resolution 3D camera system was used to analyze 3-mm and 5-mm gap formation at the subscapularis tendon-bone interface upon incremental cyclic loading. Moreover, the ultimate failure load of the repair was recorded. A Mann-Whitney test was used to assess significant differences between the 2 groups.
Results:
The comma sign repair withstood significantly more loading cycles than the single-row repair until 3-mm and 5-mm gap formation occurred (P≤ .047). The ultimate failure load did not reveal any significant differences when the 2 techniques were compared (P = .596).
Conclusion:
The results of this study show that additional stabilization of the comma sign enhanced the primary stability of subscapularis tendon repair in anterosuperior rotator cuff tears. Although this stabilization did not seem to influence the ultimate failure load, it effectively decreased the micromotion at the tendon-bone interface during cyclic loading.
Clinical Relevance:
The proposed technique for stabilization of the comma sign has shown superior biomechanical properties in comparison with a single-row repair and might thus improve tendon healing. Further clinical research will be necessary to determine its influence on the functional outcome.
Y1  - 2021
U6  - http://dx.doi.org/10.1177/03635465211031506
SN  - 1552-3365
SN  - 0363-5465
VL  - 49
IS  - 12
SP  - 3212
EP  - 3217
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Kahmann, Stephanie Lucina
A1  - Wegmann, Kilian
A1  - Ries, Christian
A1  - Staat, Manfred
A1  - Müller, Lars-Peter
T1  - Shortening osteotomy of the proximal radius — a treatment option for isolated osteoarthritis of the lateral column of the elbow joint?
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Treatment of posttraumatic osteoarthritis of the radial column of the elbow joint remains a challenging yet common issue.
While partial joint replacement leads to high revision rates, radial head excision has shown to severely increase joint instability. Shortening osteotomy of the radius could be an option to decrease the contact pressure of the radiohumeral joint and thereby pain levels without causing valgus instability. Hence, the aim of this biomechanical study was to evaluate the effects of radial shortening on axial load distribution and valgus stability of the elbow joint.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 128
EP  - 129
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Leschinger, T.
A1  - Staat, Manfred
A1  - Müller, Lars-Peter
A1  - Wegmann, Kilian
T1  - Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 130
EP  - 131
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Müller, Lars-Peter
A1  - Staat, Manfred
A1  - Kahmann, Stephanie Lucina
A1  - Wegmann, Kilian
T1  - Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 148
EP  - 149
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Nacov, Julia
A1  - Kammerlohr, Sandra
A1  - Staat, Manfred
A1  - Buess, Eduard
A1  - Leschinger, Tim
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - Intratendinous Strain Variations of the Supraspinatus Tendon Depending on Repair Technique: A Biomechanical Analysis Regarding the Cause of Medial Cuff Failure
JF  - The American Journal of Sports Medicine
Y1  - 2021
U6  - http://dx.doi.org/10.1177/03635465211006138
SN  - 1552-3365
SN  - 0363-5465
VL  - 49
IS  - 7
SP  - 1847
EP  - 1853
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Wegmann, Kilian
A1  - Kahmann, Stephanie Lucina
A1  - Heinze, Nicolai
A1  - Staat, Manfred
A1  - Neiss, Wolfram F.
A1  - Scaal, Martin
A1  - Müller, Lars P.
T1  - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow
JF  - Knee Surgery, Sports Traumatology, Arthroscopy
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s00167-017-4468-z
SN  - 1433-7347
VL  - 25
IS  - 7
SP  - 2280
EP  - 2288
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hamou, Hussam Aldin
A1  - Kotliar, Konstantin
A1  - Tan, Sonny Kian
A1  - Weiß, Christel
A1  - Blume, Christian
A1  - Clusmann, Hans
A1  - Schubert, Gerrit Alexander
A1  - Albanna, Walid
T1  - Surgical nuances and placement of subgaleal drains for supratentorial procedures—a prospective analysis of efficacy and outcome in 150 craniotomies
JF  - Acta Neurochirurgica
N2  - Background
For supratentorial craniotomy, surgical access, and closure technique, including placement of subgaleal drains, may vary considerably. The influence of surgical nuances on postoperative complications such as cerebrospinal fluid leakage or impaired wound healing overall remains largely unclear. With this study, we are reporting our experiences and the impact of our clinical routines on outcome in a prospectively collected data set.

Method
We prospectively observed 150 consecutive patients undergoing supratentorial craniotomy and recorded technical variables (type/length of incision, size of craniotomy, technique of dural and skin closure, type of dressing, and placement of subgaleal drains). Outcome variables (subgaleal hematoma/CSF collection, periorbital edema, impairment of wound healing, infection, and need for operative revision) were recorded at time of discharge and at late follow-up.

Results
Early subgaleal fluid collection was observed in 36.7% (2.8% at the late follow-up), and impaired wound healing was recorded in 3.3% of all cases, with an overall need for operative revision of 6.7%. Neither usage of dural sealants, lack of watertight dural closure, and presence of subgaleal drains, nor type of skin closure or dressing influenced outcome. Curved incisions, larger craniotomy, and tumor size, however, were associated with an increase in early CSF or hematoma collection (p < 0.0001, p = 0.001, p < 0.01 resp.), and larger craniotomy size was associated with longer persistence of subgaleal fluid collections (p < 0.05).

Conclusions
Based on our setting, individual surgical nuances such as the type of dural closure and the use of subgaleal drains resulted in a comparable complication rate and outcome. Subgaleal fluid collections were frequently observed after supratentorial procedures, irrespective of the closing technique employed, and resolve spontaneously in the majority of cases without significant sequelae. Our results are limited due to the observational nature in our single-center study and need to be validated by supportive prospective randomized design.
Y1  - 2020
U6  - http://dx.doi.org/10.1007/s00701-019-04196-6
SN  - 0942-0940
VL  - 2020
IS  - 162
SP  - 729
EP  - 736
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Hanssen, H.
A1  - Nickel, T.
A1  - Drexel, V.
A1  - Hertel, G.
A1  - Emslander, I.
A1  - Sisic, Z.
A1  - Lorang, D.
A1  - Schuster, T.
A1  - Kotliar, Konstantin
A1  - Pressler, A.
A1  - Schmidt-Trucksäss, A.
A1  - Weis, M.
A1  - Halle, M.
T1  - Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity
JF  - Atherosclerosis
Y1  - 2011
SN  - 0021-9150
VL  - 216
IS  - 2
SP  - 433
EP  - 439
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hasan, Istabrak
A1  - Keil, Ludger
A1  - Staat, Manfred
A1  - Wahl, Gerhard
A1  - Bourauel, Christoph
T1  - Determination of the frictional coefficient of the implant-antler interface : experimental approach
JF  - Biomedical Engineering / Biomedizinische Technik
N2  - The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5–0.7 and 0.3–0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.
Y1  - 2012
SN  - 1862-278X
VL  - 57
IS  - 5
SP  - 359
EP  - 363
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Heieis, Jule
A1  - Böcker, Jonas
A1  - D'Angelo, Olfa
A1  - Mittag, Uwe
A1  - Albracht, Kirsten
A1  - Schönau, Eckhard
A1  - Meyer, Andreas
A1  - Voigtmann, Thomas
A1  - Rittweger, Jörn
T1  - Curvature of gastrocnemius muscle fascicles as function of muscle–tendon complex length and contraction in humans
JF  - Physiological Reports
N2  - It has been shown that muscle fascicle curvature increases with increasing contraction level and decreasing muscle–tendon complex length. The analyses were done with limited examination windows concerning contraction level, muscle–tendon complex length, and/or intramuscular position of ultrasound imaging. With this study we aimed to investigate the correlation between fascicle arching and contraction, muscle–tendon complex length and their associated architectural parameters in gastrocnemius muscles to develop hypotheses concerning the fundamental mechanism of fascicle curving. Twelve participants were tested in five different positions (90°/105°*, 90°/90°*, 135°/90°*, 170°/90°*, and 170°/75°*; *knee/ankle angle). They performed isometric contractions at four different contraction levels (5%, 25%, 50%, and 75% of maximum voluntary contraction) in each position. Panoramic ultrasound images of gastrocnemius muscles were collected at rest and during constant contraction. Aponeuroses and fascicles were tracked in all ultrasound images and the parameters fascicle curvature, muscle–tendon complex strain, contraction level, pennation angle, fascicle length, fascicle strain, intramuscular position, sex and age group were analyzed by linear mixed effect models. Mean fascicle curvature of the medial gastrocnemius increased with contraction level (+5 m−1 from 0% to 100%; p = 0.006). Muscle–tendon complex length had no significant impact on mean fascicle curvature. Mean pennation angle (2.2 m−1 per 10°; p < 0.001), inverse mean fascicle length (20 m−1 per cm−1; p = 0.003), and mean fascicle strain (−0.07 m−1 per +10%; p = 0.004) correlated with mean fascicle curvature. Evidence has also been found for intermuscular, intramuscular, and sex-specific intramuscular differences of fascicle curving. Pennation angle and the inverse fascicle length show the highest predictive capacities for fascicle curving. Due to the strong correlations between pennation angle and fascicle curvature and the intramuscular pattern of curving we suggest for future studies to examine correlations between fascicle curvature and intramuscular fluid pressure.
KW  - biomechanics
KW  - connective tissue
KW  - physiology
KW  - ultrasound
Y1  - 2023
U6  - http://dx.doi.org/10.14814/phy2.15739
SN  - 2051-817X
VL  - 11
IS  - 11
SP  - e15739, Seite 1-11
PB  - Wiley
ER  - 
TY  - JOUR
A1  - Heiligers, Jeannette
A1  - Schoutetens, Frederic
A1  - Dachwald, Bernd
T1  - Photon-sail equilibria in the alpha centauri system
JF  - Journal of Guidance, Control, and Dynamics
Y1  - 2021
U6  - http://dx.doi.org/10.2514/1.G005446
SN  - 1533-3884
SN  - 0731-5090
SN  - 0162-3192
VL  - 44
IS  - 5
SP  - 1053
EP  - 1061
ER  - 
TY  - JOUR
A1  - Hein, Andreas M.
A1  - Eubanks, T. Marshall
A1  - Hibberd, Adam
A1  - Fries, Dan
A1  - Schneider, Jean
A1  - Lingam, Manasvi
A1  - Kennedy, Robert
A1  - Perakis, Nikolaos
A1  - Dachwald, Bernd
A1  - Kervella, Pierre
T1  - Interstellar Now! Missions to and sample returns from nearby interstellar objects
N2  - The recently discovered first high velocity hyperbolic objects passing through the Solar System, 1I/'Oumuamua and 2I/Borisov, have raised the question about near term missions to Interstellar Objects. In situ spacecraft exploration of these objects will allow the direct determination of both their structure and their chemical and isotopic composition, enabling an entirely new way of studying small bodies from outside our solar system. In this paper, we map various Interstellar Object classes to mission types, demonstrating that missions to a range of Interstellar Object classes are feasible, using existing or near-term technology. We describe flyby, rendezvous and sample return missions to interstellar objects, showing various ways to explore these bodies characterizing their surface, dynamics, structure and composition. Interstellar objects likely formed very far from the solar system in both time and space; their direct exploration will constrain their formation and history, situating them within the dynamical and chemical evolution of the Galaxy. These mission types also provide the opportunity to explore solar system bodies and perform measurements in the far outer solar system.
Y1  - 2020
SP  - 1
EP  - 8
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hein, Andreas M.
A1  - Eubanks, T. Marshall
A1  - Lingam, Manasvi
A1  - Hibberd, Adam
A1  - Fries, Dan
A1  - Schneider, Jean
A1  - Kervella, Pierre
A1  - Kennedy, Robert
A1  - Perakis, Nikolaos
A1  - Dachwald, Bernd
T1  - Interstellar now! Missions to explore nearby interstellar objects
JF  - Advances in Space Research
N2  - The recently discovered first hyperbolic objects passing through the Solar System, 1I/’Oumuamua and 2I/Borisov, have raised the question about near term missions to Interstellar Objects. In situ spacecraft exploration of these objects will allow the direct determination of both their structure and their chemical and isotopic composition, enabling an entirely new way of studying small bodies from outside our solar system. In this paper, we map various Interstellar Object classes to mission types, demonstrating that missions to a range of Interstellar Object classes are feasible, using existing or near-term technology. We describe flyby, rendezvous and sample return missions to interstellar objects, showing various ways to explore these bodies characterizing their surface, dynamics, structure and composition. Their direct exploration will constrain their formation and history, situating them within the dynamical and chemical evolution of the Galaxy. These mission types also provide the opportunity to explore solar system bodies and perform measurements in the far outer solar system.
KW  - Interstellar objects
KW  - Trajectories
KW  - Missions
Y1  - 2022
U6  - http://dx.doi.org/10.1016/j.asr.2021.06.052
SN  - 0273-1177
VL  - 69
IS  - 1
SP  - 402
EP  - 414
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes
JF  - Isokinetics and Exercise Science
N2  - BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results.
Y1  - 2018
U6  - http://dx.doi.org/10.3233/IES-184111
SN  - 1878-5913
VL  - 26
IS  - 4
SP  - 265
EP  - 274
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Increased shoulder muscle stretch reflex elicitability in supine subject posture
JF  - Isokinetics and Exercise Science
N2  - BACKGROUND: Muscle stretch reflexes are widely used to examine neural muscle function. The knowledge of reflex response in muscles crossing the shoulder is limited. OBJECTIVE: To quantify reflex modulation according to various subject postures and different procedures of muscle pre-activation steering. METHODS: Thirteen healthy male participants performed two sets of external shoulder rotation stretches in various positions and with different procedures of muscle pre-activation steering on an isokinetic dynamometer over a range of two different pre-activation levels. All stretches were applied with a dynamometer acceleration of 104∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexive response was observed in all tested muscles in all experimental conditions. The reflex elicitation rate revealed a significant muscle main effect (F (5,288) = 2.358, ρ= 0.040; η2= 0.039; f= 0.637) and a significant test condition main effect (F (1,288) = 5.884, ρ= 0.016; η2= 0.020; f= 0.143). Reflex latency revealed a significant muscle pre-activation level main effect (F (1,274) = 5.008, ρ= 0.026; η2= 0.018; f= 0.469). CONCLUSION: Muscular reflexive response was more consistent in the primary internal rotators of the shoulder. Supine posture in combination with visual feedback of muscle pre-activation level enhanced the reflex elicitation rate.
Y1  - 2020
U6  - http://dx.doi.org/10.3233/IES-192219
SN  - 1878-5913
VL  - 28
IS  - 2
SP  - 139
EP  - 146
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Test-retest reliability of the internal shoulder rotator muscles' stretch reflex in healthy men
JF  - Journal of Electromyography and Kinesiology
N2  - Until now the reproducibility of the short latency stretch reflex of the internal rotator muscles of the glenohumeral joint has not been identified. Twenty-three healthy male participants performed three sets of external shoulder rotation stretches with various pre-activation levels on two different dates of measurement to assess test-retest reliability. All stretches were applied with a dynamometer acceleration of 104°/s2 and a velocity of 150°/s. Electromyographical response was measured via surface EMG. Reflex latencies showed a pre-activation effect (ƞ2 = 0,355). ICC ranged from 0,735 to 0,909 indicating an overall “good” relative reliability. SRD 95% lay between ±7,0 to ±12,3 ms.. The reflex gain showed overall poor test-retest reproducibility. The chosen methodological approach presented a suitable test protocol for shoulder muscles stretch reflex latency evaluation. A proof-of-concept study to validate the presented methodical approach in shoulder involvement including subjects with clinically relevant conditions is recommended.
KW  - stretch reflex
KW  - shoulder
KW  - test-retest reliability
KW  - intraclass correlation coefficient
KW  - standard error of measurement
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.jelekin.2021.102611
SN  - 1050-6411
VL  - 62
IS  - Article 102611
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heinzel, Alexander
A1  - Schäfer, Ralf
A1  - Müller, Hans-Wilhelm
A1  - Schieffer, Andre
A1  - Ingenhag, Ariane
A1  - Eickhoff, Simon B.
A1  - Northoff, Georg
A1  - Franz, Matthias
A1  - Hautzel, Hubertus
T1  - Increased Activation of the Supragenual Anterior Cingulate Cortex during Visual Emotional Processing in Male Subjects with High Degrees of Alexithymia: An Event-Related fMRI Study
JF  - Psychotherapy and Psychosomatics
N2  - Background: One of the most prominent neurobiological models of alexithymia assumes an altered function of the anterior cingulate cortex (ACC) as the crucial neural correlate of alexithymia. So far functional imaging studies have yielded inconclusive results. Therefore, we tested this hypothesis in healthy alexithymics and nonalexithymics in an event-related fMRI study.
Methods: Thirty high- and 30 low-alexithymic right-handed male subjects (selected by the 20-item Toronto Alexithymia Scale, TAS-20) were investigated with event-related fMRI using a picture viewing paradigm. The stimuli consisted of happy, fearful and neutral facial expressions (Ekman-Friesen) as well as positive, negative and neutral pictures from the International Affective Picture System.
Results: Contrasting the high-alexithymic with the low-alexithymic group we observed increased activation of the supragenual ACC for different emotional valences as well as for different emotional stimuli. Moreover, there was a positive correlation of the ACC with the individual TAS-20 scores but no correlations with the individual Beck Depression Inventory scores. Additionally, there was no difference in activity of the amygdala. 
Conclusions: We demonstrated that the supragenual ACC is constantly activated more strongly in alexithymic subjects and that this activation is related to the symptoms of alexithymia and not to associated symptoms such as depression. Therefore, our findings support the hypothesis of an altered function of the ACC in alexithymia.
Y1  - 2010
U6  - http://dx.doi.org/10.1159/000320121
SN  - 0033-3190
VL  - 79
IS  - 6
SP  - 363
EP  - 370
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Heinzel, Alexander
A1  - Schäfer, Ralf
A1  - Müller, Hans-Wilhelm
A1  - Schieffer, Andre
A1  - Ingenhag, Ariane
A1  - Northoff, Georg
A1  - Franz, Matthias
A1  - Hautzel, Hubertus
T1  - Differential modulation of valence and arousal in high-alexithymic and low-alexithymic individuals
JF  - Neuroreport
N2  - High-alexithymic individuals are characterized by an impaired ability to identify and communicate emotions whereas low-alexithymic individuals have a wide-ranging ability to deal with emotions. This study examined the hypothesis that valence and arousal modifications of emotional stimuli differentially modulate cortical regions in high-alexithymic and low-alexithymic individuals. To this end, 28 high-alexithymic and 25 low-alexithymic individuals were investigated with event-related fMRI using visual emotional stimuli. We found differential neural activations in the dorsal anterior cingulate, the insula and the amygdala. We suggest that these differences may account for the impaired ability of high-alexithymic individuals to appropriately handle emotional stimuli.
Y1  - 2010
U6  - http://dx.doi.org/10.1097/WNR.0b013e32833f38e0
SN  - 1473-558X
VL  - 21
IS  - 15
SP  - 998
EP  - 1002
PB  - Lippincott Williams & Wilkins
CY  - London
ER  - 
TY  - JOUR
A1  - Herssens, Nolan
A1  - Cowburn, James
A1  - Albracht, Kirsten
A1  - Braunstein, Bjoern
A1  - Cazzola, Dario
A1  - Colyer, Steffi
A1  - Minetti, Alberto E.
A1  - Pavei, Gaspare
A1  - Rittweger, Jörn
A1  - Weber, Tobias
A1  - Green, David A.
ED  - Cattaneo, Luigi
T1  - Movement in low gravity environments (MoLo) programme – the MoLo-L.O.O.P. study protocol
JF  - PLOS ONE / Public Library of Science
N2  - Exposure to prolonged periods in microgravity is associated with deconditioning of the musculoskeletal system due to chronic changes in mechanical stimulation. Given astronauts will operate on the Lunar surface for extended periods of time, it is critical to quantify both external (e.g., ground reaction forces) and internal (e.g., joint reaction forces) loads of relevant movements performed during Lunar missions. Such knowledge is key to predict musculoskeletal deconditioning and determine appropriate exercise countermeasures associated with extended exposure to hypogravity.
Y1  - 2022
U6  - http://dx.doi.org/10.1371/journal.pone.0278051
SN  - 1932-6203
VL  - 17
IS  - 11
PB  - Plos
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Duong, Minh Tuan
A1  - Staat, Manfred
T1  - Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement
JF  - Journal of the mechanical behavior of biomedical materials
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.jmbbm.2017.06.012
SN  - 1751-6161
VL  - 74
SP  - 400
EP  - 410
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Staat, Manfred
T1  - Optical strain measurement for the modeling of surgical meshes and their porosity
JF  - Current Directions in Biomedical Engineering
N2  - The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.
Y1  - 2018
U6  - http://dx.doi.org/10.1515/cdbme-2018-0045
SN  - 2364-5504
VL  - Band 4
IS  - 1
SP  - 181
EP  - 184
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Staat, Manfred
A1  - Perez-Viana, Daniel
A1  - Simmen, Hans-Peter
A1  - Neuhaus, Valentin
A1  - Pape, Hans-Christoph
A1  - Prescher, Andreas
A1  - Ciritsis, Bernhard
T1  - Biomechanical in vitro examination of a standardized low-volume tubular femoroplasty
JF  - Clinical Biomechanics
N2  - Background
Osteoporosis is associated with the risk of fractures near the hip. Age and comorbidities increase the perioperative risk. Due to the ageing population, fracture of the proximal femur also proves to be a socio-economic problem. Preventive surgical measures have hardly been used so far.

Methods
10 pairs of human femora from fresh cadavers were divided into control and low-volume femoroplasty groups and subjected to a Hayes fall-loading fracture test. The results of the respective localization and classification of the fracture site, the Singh index determined by computed tomography (CT) examination and the parameters in terms of fracture force, work to fracture and stiffness were evaluated statistically and with the finite element method. In addition, a finite element parametric study with different position angles and variants of the tubular geometry of the femoroplasty was performed.

Findings
Compared to the control group, the work to fracture could be increased by 33.2%. The fracture force increased by 19.9%. The used technique and instrumentation proved to be standardized and reproducible with an average poly(methyl methacrylate) volume of 10.5 ml. The parametric study showed the best results for the selected angle and geometry.

Interpretation
The cadaver studies demonstrated the biomechanical efficacy of the low-volume tubular femoroplasty. The numerical calculations confirmed the optimal choice of positioning as well as the inner and outer diameter of the tube in this setting. The standardized minimally invasive technique with the instruments developed for it could be used in further comparative studies to confirm the measured biomechanical results.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.clinbiomech.2020.105104
VL  - 80
IS  - Art. 105104
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hunker, Jan L.
A1  - Gossmann, Matthias
A1  - Raman, Aravind Hariharan
A1  - Linder, Peter
T1  - Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility
JF  - Journal of Pharmacological and Toxicological Methods
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.vascn.2021.107044
SN  - 1056-8719
VL  - 111
IS  - Article number 107044
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Jan Thimo, Grundmann
A1  - Bauer, Waldemar
A1  - Biele, Jens
A1  - Boden, Ralf
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, David
T1  - Capabilities of Gossamer-1 derived small spacecraft solar sails carrying Mascot-derived nanolanders for in-situ surveying of NEAs
JF  - Acta Astronautica
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.actaastro.2018.03.019
SN  - 0094-5765
VL  - 156
IS  - 3
SP  - 330
EP  - 362
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jansen, S. V.
A1  - Behbahani, Mehdi
A1  - Laumen, M.
A1  - Kaufmann, T.
A1  - Hormes, M.
A1  - Behr, M.
A1  - Schmitz-Rode, T.
A1  - Steinseifer, U.
T1  - Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation
Y1  - 2010
N1  - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Jansen, Sebastian
A1  - Behbahani, Mehdi
A1  - Laumen, Marco
A1  - Kaufmann, Tim
A1  - Hormes, Marcus
A1  - Schmitz-Rode, Thomas
A1  - Behr, Marek
A1  - Steinseifer, Ulrich
T1  - 3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques
Y1  - 2010
N1  - abstract ; IV International Symposium on Modelling of Physiological Flows, Sardinia, Italy, June 02-05, 2010 ; MPF2010
ER  - 
TY  - JOUR
A1  - Jayaraman, Chandrasekaran
A1  - Mummidisetty, Chaitanya Krishna
A1  - Loesch, Alexandra
A1  - Kaur, Sandi
A1  - Hoppe-Ludwig, Shenan
A1  - Staat, Manfred
A1  - Jayaraman, Arun
T1  - Postural and metabolic benefits of using a forearm support walker in older adults with impairments
JF  - Archives of Physical Medicine and Rehabilitation
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.apmr.2018.10.001
SN  - 0003-9993
VL  - Volume 100
IS  - Issue 4
SP  - 638
EP  - 647
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jiminez German, Salvador
A1  - Behbahani, Mehdi
A1  - Miettinen, Susanna
A1  - Grijpma, Dirk W.
A1  - Haimi, Suvi P.
T1  - Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes
JF  - Macromolecular symposia
Y1  - 2013
SN  - 0258-0322
VL  - Vol. 334
IS  - Iss. 1
SP  - 133
EP  - 142
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Wind and fairness in ski jumping: A computer modelling analysis
JF  - Journal of Biomechanics
N2  - Wind is closely associated with the discussion of fairness in ski jumping. To counter-act its influence on the jump length, the International Ski Federation (FIS) has introduced a wind compensation approach. We applied three differently accurate computer models of the flight phase with wind (M1, M2, and M3) to study the jump length effects of various wind scenarios. The previously used model M1 is accurate for wind blowing in direction of the flight path, but inaccuracies are to be expected for wind directions deviating from the tangent to the flight path. M2 considers the change of airflow direction, but it does not consider the associated change in the angle of attack of the skis which additionally modifies drag and lift area time functions. M3 predicts the length effect for all wind directions within the plane of the flight trajectory without any mathematical simplification. Prediction errors of M3 are determined only by the quality of the input data: wind velocity, drag and lift area functions, take-off velocity, and weight. For comparing the three models, drag and lift area functions of an optimized reference jump were used. Results obtained with M2, which is much easier to handle than M3, did not deviate noticeably when compared to predictions of the reference model M3. Therefore, we suggest to use M2 in future applications. A comparison of M2 predictions with the FIS wind compensation system showed substantial discrepancies, for instance: in the first flight phase, tailwind can increase jump length, and headwind can decrease it; this is opposite of what had been anticipated before and is not considered in the current wind compensation system in ski jumping.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.jbiomech.2018.05.001
SN  - 0021-9290
IS  - 75
SP  - 147
EP  - 153
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Optimization of the flight technique in ski jumping: the influence of wind
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jbiomech.2019.03.023
IS  - Early view
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
T1  - Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue
JF  - GAMM - Mitteilungen der Gesellschaft für Angewandte Mathematik und Mechanik
Y1  - 2019
U6  - http://dx.doi.org/10.1002/gamm.201900002
SN  - 1522-2608
VL  - 42
IS  - 4
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
T1  - Erratum to "Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue" [GAMM-Mitteilungen, (2019), 42, 4, 10.1002/gamm.201900002]
JF  - GAMM-Mitteilungen
Y1  - 2020
U6  - http://dx.doi.org/10.1002/gamm.202000011
SN  - 1522-2608
N1  - Refers to: Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue. Alexander Jung, Manfred Staat.
Volume 42, Issue 4. GAMM-Mitteilungen, 2019. https://doi.org/10.1002/gamm.201900002
VL  - 43
IS  - 4
PB  - Wiley-VCH GmbH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
A1  - Müller, Wolfram
T1  - Flight style optimization in ski jumping on normal, large, and ski flying hills
JF  - Journal of biomechanics
Y1  - 2013
SN  - 1873-2380 (E-Journal); 0021-9290 (Print)
N1  - Corrigendum to “Flight style optimization in ski jumping on normal, large, and ski flying hills” [J. Biomech 47 (2014) 716-722] Journal of Biomechanics, 2018;71:313.
VL  - Vol. 47
IS  - Iss. 3
SP  - 716
EP  - 722
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
A1  - Müller, Wolfram
T1  - Corrigendum to “Flight style optimization in ski jumping on normal, large, and ski flying hills” [J. Biomech 47 (2014) 716–722]
JF  - Journals of Biomechanics
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.jbiomech.2018.02.001
SN  - 0021-9290
N1  - refers to 
 Journal of Biomechanics Vol 47, Issue 3, Pages 716-722:
https://doi.org/10.1016/j.jbiomech.2013.11.021
SP  - 313
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Karamanidis, Kiros
A1  - Albracht, Kirsten
A1  - Braunstein, Bjoern
A1  - Catala, Maria Moreno
A1  - Goldmann, Jan-Peter
A1  - Brüggemann, Gert-Peter
T1  - Lower leg musculoskeletal geometry and sprint performance
JF  - Gait and Posture
N2  - The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components.
Y1  - 2011
U6  - http://dx.doi.org/10.1016/j.gaitpost.2011.03.009
SN  - 0966-6362
VL  - 34
IS  - 1
SP  - 138
EP  - 141
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kaul, D. K.
A1  - Koshkaryev, A.
A1  - Artmann, Gerhard
A1  - Barshtein, G.
A1  - Yedgar, S.
T1  - Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistance
JF  - American Journal of Physiology : Heart and Circulation Physiology . 295 (2008), H. 4
Y1  - 2008
SN  - 1522-1539
VL  - 295
IS  - 4
SP  - H1788
EP  - H1793
ER  - 
TY  - JOUR
A1  - Ketelhut, Maike
A1  - Brügge, G. M.
A1  - Göll, Fabian
A1  - Braunstein, Bjoern
A1  - Albracht, Kirsten
A1  - Abel, Dirk
T1  - Adaptive iterative learning control of an industrial robot during neuromuscular training
JF  - IFAC PapersOnLine
N2  - To prevent the reduction of muscle mass and loss of strength coming along with the human aging process, regular training with e.g. a leg press is suitable. However, the risk of training-induced injuries requires the continuous monitoring and controlling of the forces applied to the musculoskeletal system as well as the velocity along the motion trajectory and the range of motion. In this paper, an adaptive norm-optimal iterative learning control algorithm to minimize the knee joint loadings during the leg extension training with an industrial robot is proposed. The response of the algorithm is tested in simulation for patients with varus, normal and valgus alignment of the knee and compared to the results of a higher-order iterative learning control algorithm, a robust iterative learning control and a recently proposed conventional norm-optimal iterative learning control algorithm. Although significant improvements in performance are made compared to the conventional norm-optimal iterative learning control algorithm with a small learning factor, for the developed approach as well as the robust iterative learning control algorithm small steady state errors occur.
KW  - Iterative learning control
KW  - Robotic rehabilitation
KW  - Adaptive control
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.ifacol.2020.12.741
SN  - 2405-8963
VL  - 53
IS  - 2
SP  - 16468
EP  - 16475
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ketelhut, Maike
A1  - Göll, Fabian
A1  - Braunstein, Björn
A1  - Albracht, Kirsten
A1  - Abel, Dirk
T1  - Comparison of different training algorithms for the leg extension training with an industrial robot
JF  - Current Directions in Biomedical Engineering
N2  - In the past, different training scenarios have been developed and implemented on robotic research platforms, but no systematic analysis and comparison have been done so far. This paper deals with the comparison of an isokinematic (motion with constant velocity) and an isotonic (motion against constant weight) training algorithm. Both algorithms are designed for a robotic research platform consisting of a 3D force plate and a high payload industrial robot, which allows leg extension training with arbitrary six-dimensional motion trajectories. In the isokinematic as well as the isotonic training algorithm, individual paths are defined i n C artesian s pace by sufficient s upport p oses. I n t he i sotonic t raining s cenario, the trajectory is adapted to the measured force as the robot should only move along the trajectory as long as the force applied by the user exceeds a minimum threshold. In the isotonic training scenario however, the robot’s acceleration is a function of the force applied by the user. To validate these findings, a simulative experiment with a simple linear trajectory is performed. For this purpose, the same force path is applied in both training scenarios. The results illustrate that the algorithms differ in the force dependent trajectory adaption.
KW  - Rehabilitation Technology and Prosthetics
KW  - Surgical Navigation and Robotics
Y1  - 2018
U6  - http://dx.doi.org/10.1515/cdbme-2018-0005
SN  - 2364-5504
VL  - 4
IS  - 1
SP  - 17
EP  - 20
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ketelhut, Maike
A1  - Kolditz, Melanie
A1  - Göll, Fabian
A1  - Braunstein, Bjoern
A1  - Albracht, Kirsten
A1  - Abel, Dirk
T1  - Admittance control of an industrial robot during resistance training
JF  - IFAC-PapersOnLine
N2  - Neuromuscular strength training of the leg extensor muscles plays an important role in the rehabilitation and prevention of age and wealth related diseases. In this paper, we focus on the design and implementation of a Cartesian admittance control scheme for isotonic training, i.e. leg extension and flexion against a predefined weight. For preliminary testing and validation of the designed algorithm an experimental research and development platform consisting of an 
industrial robot and a force plate mounted at its end-effector has been used. Linear, diagonal and arbitrary two-dimensional motion trajectories with different weights for the leg extension and flexion part are applied. The proposed algorithm is easily adaptable to trajectories consisting of arbitrary six-dimensional poses and allows the implementation of individualized trajectories.
KW  - Assistive technology
KW  - Rehabilitation engineering
KW  - Human-Computer interaction
KW  - Automatic control
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.ifacol.2019.12.102
SN  - 2405-8963
N1  - 14th IFAC Symposium on Analysis, Design, and Evaluation of Human Machine Systems HMS 2019
Tallinn, Estonia, 16–91 September 2019
VL  - 52
IS  - 19
SP  - 223
EP  - 228
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kezerashvili, Roman Ya
A1  - Dachwald, Bernd
T1  - Preface: Solar sailing: Concepts, technology, and missions II
JF  - Advances in Space Research
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.asr.2021.01.037
SN  - 0273-1177
VL  - 67
IS  - 9
SP  - 2559
EP  - 2560
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Knox, Ronald
A1  - Bruggemann, Andrea
A1  - Gossmann, Matthias
A1  - Thomas, Ulrich
A1  - Horváth, András
A1  - Dragicevic, Elena
A1  - Stoelzle-Feix, Sonja
A1  - Fertig, Niels
A1  - Jung, Alexander
A1  - Raman, Aravind Hariharan
A1  - Staat, Manfred
A1  - Linder, Peter
T1  - Combining physiological relevance and throughput for in vitro cardiac contractility measurement
JF  - Biophysical Journal
N2  - Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.bpj.2019.11.3104
SN  - 0006-3495
N1  - Raman, Arayind Hariharan 
im Artikel unter dem Namen: Raman, Alexander H.
VL  - 118
IS  - Issue 3, Supplement 1
SP  - 570a
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kodomskoi, Leonid
A1  - Kotliar, Konstantin
A1  - Schröder, Andreas
A1  - Weiss, Michael
A1  - Hille, Konrad
T1  - Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter
JF  - Journal of Glaucoma
Y1  - 2019
U6  - http://dx.doi.org/10.1097/IJG.0000000000001321
SN  - 1057-0829
IS  - Epub ahead of print
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Kolditz, Melanie
A1  - Albin, Thivaharan
A1  - Abel, Dirk
A1  - Fasse, Alessandro
A1  - Brüggemann, Gert-Peter
A1  - Albracht, Kirsten
T1  - Evaluation of foot position and orientation as manipulated variables to control external knee adduction moments in leg extension training
JF  - Computer methods and programs in biomedicine
N2  - Background and Objective
Effective leg extension training at a leg press requires high forces, which need to be controlled to avoid training-induced damage. In order to avoid high external knee adduction moments, which are one reason for unphysiological loadings on knee joint structures, both training movements and the whole reaction force vector need to be observed. In this study, the applicability of lateral and medial changes in foot orientation and position as possible manipulated variables to control external knee adduction moments is investigated. As secondary parameters both the medio-lateral position of the center of pressure and the frontal-plane orientation of the reaction force vector are analyzed.

Methods
Knee adduction moments are estimated using a dynamic model of the musculoskeletal system together with the measured reaction force vector and the motion of the subject by solving the inverse kinematic and dynamic problem. Six different foot conditions with varying positions and orientations of the foot in a static leg press are evaluated and compared to a neutral foot position.

Results
Both lateral and medial wedges under the foot and medial and lateral shifts of the foot can influence external knee adduction moments in the presented study with six healthy subjects. Different effects are observed with the varying conditions: the pose of the leg is changed and the direction and center of pressure of the reaction force vector is influenced. Each effect results in a different direction or center of pressure of the reaction force vector.

Conclusions
The results allow the conclusion that foot position and orientation can be used as manipulated variables in a control loop to actively control knee adduction moments in leg extension training.
KW  - External knee adduction moments
KW  - Manipulated variables
KW  - Inverse dynamic problem
KW  - Inverse kinematic problem
KW  - Musculoskeletal model
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.cmpb.2016.09.005
SN  - 0169-2607
N1  - Part of special issue: "SI: Personalised Models and System Identification"
VL  - 171
SP  - 81
EP  - 86
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Konstantinidis, Konstantinos
A1  - Flores Martinez, Claudio
A1  - Dachwald, Bernd
A1  - Ohndorf, Andreas
A1  - Dykta, Paul
A1  - Bowitz, Pascal
A1  - Rudolph, Martin
A1  - Digel, Ilya
A1  - Kowalski, Julia
A1  - Voigt, Konstantin
A1  - Förstner, Roger
T1  - A lander mission to probe subglacial water on Saturn's moon enceladus for life
JF  - Acta astronautica
Y1  - 2015
SN  - 1879-2030 (E-Journal); 0094-5765 (Print)
VL  - Vol. 106
SP  - 63
EP  - 89
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schmeets, Ralf
A1  - Gosau, Martin
A1  - Friedrich, Reinhard E.
A1  - Fuest, Sandra
A1  - Behbahani, Mehdi
A1  - Barbeck, Mike
A1  - Rutkowski, Rico
A1  - Burg, Simon
A1  - Kluwe, Lan
A1  - Henningsen, Anders
T1  - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
JF  - In Vivo
Y1  - 2019
U6  - http://dx.doi.org/10.21873/invivo.11536
SN  - 1791-7549
VL  - 33
IS  - 3
SP  - 757
EP  - 762
ER  -