TY - BOOK A1 - Dikta, Gerhard T1 - Beiträge zur nichtparametrischen Schätzung der Regressionsfunktion Y1 - 1987 N1 - Gießen, Univ., Diss. ER - TY - JOUR A1 - Dikta, Gerhard T1 - Time series methods to forecast patent filings JF - Forecasting innovations : methods for predicting numbers of patent filings ; with 71 tables / Peter Hingley ; Marc Nicolas (ed.), Y1 - 2006 SN - 978-3-540-35991-3 U6 - http://dx.doi.org/10.1007/3-540-35992-3_6 N1 - ISBN 3-540-35991-5 SP - 95 EP - 124 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Dikta, Gerhard T1 - Bootstrap Approximation of Nearest Neighbor Regression Function Estimates JF - Journal of Multivariate Analysis. 32 (1990), H. 2 Y1 - 1990 SN - 0047-259X SP - 213 EP - 229 ER - TY - JOUR A1 - Dikta, Gerhard T1 - Asymptotic Normality Under the Koziol-Green Model JF - Communications in Statistics: Theory and Methods. 24 (1995), H. 6 Y1 - 1995 SN - 0361-0926 SP - 1537 EP - 1549 ER - TY - JOUR A1 - Dikta, Gerhard T1 - A Note on the Rate of Convergence of the Bootstrap JF - Journal of Approximation Theory. 75 (1993), H. 1 Y1 - 1993 SN - 0021-9045 SP - 112 EP - 114 ER - TY - JOUR A1 - Dikta, Gerhard T1 - On Semiparametric Random Censorship Models JF - Journal of Statistical Planning and Inference. 66 (1998), H. 2 Y1 - 1998 SN - 0378-3758 SP - 253 EP - 279 ER - TY - JOUR A1 - Dikta, Gerhard T1 - The Strong Law under Semiparametric Random Censorship Models JF - Journal of Statistical Planning and Inference. 83 (2000), H. 1 Y1 - 2000 SN - 0378-3758 SP - 1 EP - 10 ER - TY - JOUR A1 - Dikta, Gerhard T1 - Weak Representation of the Cumulative Hazard Function under Semiparametric Random Censorship Models JF - Statistics. 35 (2001), H. 4 Y1 - 2001 SN - 0233-1888 SP - 395 EP - 410 ER - TY - JOUR A1 - Dikta, Gerhard T1 - The Bootstrap in Binary Model Diagnostics JF - Frontiers of applied and computational mathematics : New Jersey Institute of Technology, USA, 19 - 21 May 2008 ; [dedicated to Daljit Singh Ahluwalia on his 75th birthday ; Fifth Annual Frontiers in Applied and Computational Mathematics Conference (FACM '08) ; selection of papers] / ed. by Denis Blackmore Y1 - 2008 SN - 978-981-283-528-4 SP - 119 EP - 126 PB - World Scientific CY - Hackensack, NJ [u.a.] ER - TY - CHAP A1 - Dikta, Gerhard T1 - Fundamentals of applied probability and basic statistics T2 - Critical care nephrology / [Hrsg.:] Claudio Ronco and Rinaldo Bellomo Y1 - 1998 SN - 978-94-010-6306-7 SP - 51 EP - 61 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Dikta, Gerhard T1 - Asymptotically efficient estimation under semi-parametric random censorship models JF - Journal of multivariate analysis N2 - We study the estimation of some linear functionals which are based on an unknown lifetime distribution. The observations are assumed to be generated under the semi-parametric random censorship model (SRCM), that is, a random censorship model where the conditional expectation of the censoring indicator given the observation belongs to a parametric family. Under this setup a semi-parametric estimator of the survival function was introduced by the author. If the parametric model assumption is correct, it is known that the estimated functional which is based on this semi-parametric estimator is asymptotically at least as efficient as the corresponding one which rests on the nonparametric Kaplan–Meier estimator. In this paper we show that the estimated functional which is based on this semi-parametric estimator is asymptotically efficient with respect to the class of all regular estimators under this semi-parametric model. Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.jmva.2013.10.002 SN - 1095-7243 (E-Journal); 0047-259X (Print) VL - 124 SP - 10 EP - 24 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dikta, Gerhard T1 - Semi-parametric random censorship models JF - From Statistics to Mathematical Finance : Festschrift in Honour of Winfried Stute Y1 - 2017 SN - 978-3-319-50986-0 U6 - http://dx.doi.org/10.1007/978-3-319-50986-0_3 SP - 43 EP - 56 PB - Springer CY - Berlin ER - TY - JOUR A1 - Dikta, Gerhard A1 - Degenring, D. A1 - Froemmel, C. A1 - Takors, R. T1 - Sensitivity analysis for the reduction of complex metabolism models / Degenring, D. ; Froemmel, C. ; Dikta, G.; Takors, R. JF - Journal of Process Control. 14 (2004) Y1 - 2004 SN - 0959-1524 SP - 729 EP - 745 ER - TY - JOUR A1 - Dikta, Gerhard A1 - Ghorai, J. K. T1 - Bootstrap Approximation with Censored Data under the Proportional Hazard Model JF - Communications in Statistics: Theory and Methods. 19 (1990), H. 2 Y1 - 1990 SN - 0361-0926 SP - 573 EP - 581 ER - TY - JOUR A1 - Dikta, Gerhard A1 - Ghorai, Jugal A1 - Schmidt, Christian T1 - The Central Limit Theorem under Semiparametric Random Censorship Models JF - Journal of Statistical Planning and Inference. 127 (2005), H. 1 Y1 - 2005 SN - 0378-3758 SP - 23 EP - 51 ER - TY - JOUR A1 - Dikta, Gerhard A1 - Hausmann, Rolf A1 - Schmidt, Christian T1 - Some Simulation Results under Random Censorship Models Y1 - 2002 N1 - gesehen 18.06.2007 SP - 1 EP - 12 ER - TY - JOUR A1 - Dikta, Gerhard A1 - Kurtz, B. A1 - Stute, W. T1 - Sequential Fixed-Width Confidence Bands for Distribution Functions Under Random Censoring JF - Metrika. 36 (1989) Y1 - 1989 SN - 0026-1335 SP - 167 EP - 176 ER - TY - JOUR A1 - Dikta, Gerhard A1 - Kvesic, Marsel A1 - Schmidt, Christian T1 - Bootstrap Approximations in Model Checks for Binary Data JF - Journal of the American Statistical Association. 101 (2006), H. 474 Y1 - 2006 SN - 0162-1459 SP - 521 EP - 530 ER - TY - JOUR A1 - Dikta, Gerhard A1 - Kühlheim, René A1 - Mendonca, Jorge A1 - Una-Alcarez, Jacobo de T1 - Asymptotic representation of presmoothed Kaplan–Meier integrals with covariates in a semiparametric censorship model JF - Journal of Statistical Planning and Inference Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.jspi.2015.12.001 SN - 0378-3758 VL - Vol. 171 SP - 10 EP - 37 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dikta, Gerhard A1 - Reißel, Martin A1 - Harlaß, Carsten T1 - Semi-parametric survival function estimators deduced from an identifying Volterra type integral equation JF - Journal of multivariate analysis N2 - Based on an identifying Volterra type integral equation for randomly right censored observations from a lifetime distribution function F, we solve the corresponding estimating equation by an explicit and implicit Euler scheme. While the first approach results in some known estimators, the second one produces new semi-parametric and pre-smoothed Kaplan–Meier estimators which are real distribution functions rather than sub-distribution functions as the former ones are. This property of the new estimators is particular useful if one wants to estimate the expected lifetime restricted to the support of the observation time. Specifically, we focus on estimation under the semi-parametric random censorship model (SRCM), that is, a random censorship model where the conditional expectation of the censoring indicator given the observation belongs to a parametric family. We show that some estimated linear functionals which are based on the new semi-parametric estimator are strong consistent, asymptotically normal, and efficient under SRCM. In a small simulation study, the performance of the new estimator is illustrated under moderate sample sizes. Finally, we apply the new estimator to a well-known real dataset. KW - Volterra integral equation KW - Product-integration KW - Asymptotic efficiency KW - Semi-parametric random censorship model KW - Censored data KW - Survival analysis Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.jmva.2016.02.008 IS - 147 SP - 273 EP - 284 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Dikta, Gerhard A1 - Scheer, Marsel T1 - Bootstrap Methods: With Applications in R N2 - This book provides a compact introduction to the bootstrap method. In addition to classical results on point estimation and test theory, multivariate linear regression models and generalized linear models are covered in detail. Special attention is given to the use of bootstrap procedures to perform goodness-of-fit tests to validate model or distributional assumptions. In some cases, new methods are presented here for the first time. The text is motivated by practical examples and the implementations of the corresponding algorithms are always given directly in R in a comprehensible form. Overall, R is given great importance throughout. Each chapter includes a section of exercises and, for the more mathematically inclined readers, concludes with rigorous proofs. The intended audience is graduate students who already have a prior knowledge of probability theory and mathematical statistics. Y1 - 2021 SN - 978-3-030-73480-0 U6 - http://dx.doi.org/10.1007/978-3-030-73480-0 PB - Springer CY - Cham ER - TY - JOUR A1 - Dikta, Gerhard A1 - Subramanian, Sundarraman T1 - Inverse censoring weighted median regression / Sundarraman Subramanian and Gerhard Dikta JF - Statistical Methodology. 6 (2009), H. 6 Y1 - 2009 SN - 1572-3127 SP - 594 EP - 603 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ditzhaus, Marc A1 - Gaigall, Daniel T1 - Testing marginal homogeneity in Hilbert spaces with applications to stock market returns JF - Test N2 - This paper considers a paired data framework and discusses the question of marginal homogeneity of bivariate high-dimensional or functional data. The related testing problem can be endowed into a more general setting for paired random variables taking values in a general Hilbert space. To address this problem, a Cramér–von-Mises type test statistic is applied and a bootstrap procedure is suggested to obtain critical values and finally a consistent test. The desired properties of a bootstrap test can be derived that are asymptotic exactness under the null hypothesis and consistency under alternatives. Simulations show the quality of the test in the finite sample case. A possible application is the comparison of two possibly dependent stock market returns based on functional data. The approach is demonstrated based on historical data for different stock market indices. Y1 - 2022 U6 - http://dx.doi.org/10.1007/s11749-022-00802-5 SN - 1863-8260 VL - 2022 IS - 31 SP - 749 EP - 770 PB - Springer ER - TY - JOUR A1 - Ditzhaus, Marc A1 - Gaigall, Daniel T1 - A consistent goodness-of-fit test for huge dimensional and functional data JF - Journal of Nonparametric Statistics N2 - A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cramér-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals. KW - Cramér-von-Mises statistic KW - separable Hilbert space KW - huge dimensional data KW - functional data Y1 - 2018 U6 - http://dx.doi.org/10.1080/10485252.2018.1486402 SN - 1029-0311 VL - 30 IS - 4 SP - 834 EP - 859 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Doll, T. A1 - Scharnagl, K. A1 - Winter, R. A1 - Bögner, M. A1 - Eisele, I. A1 - Ostrik, B. A1 - Schöning, Michael Josef T1 - Work function gas sensors - reference layers and signal analysis JF - Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1 Y1 - 1998 SN - 0-7503-0595-9 N1 - Eurosensors ; (12, 1998, Southampton) ; UK Conference on Sensors and Their Applications ; (9, 1998, Southampton) SP - 143 EP - 146 PB - Inst. of Physics Publ. CY - Bristol [u.a.] ER - TY - JOUR A1 - Doll, Theodor A1 - Wagner, Torsten A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Schöning (eds.) JF - Physica status solidi (a) Y1 - 2016 U6 - http://dx.doi.org/10.1002/pssa.201670641 SN - 1862-6319 VL - 213 IS - 6 SP - 1393 EP - 1394 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Doorschodt, B. M. A1 - Schreinemachers, M. C. J. M. A1 - Behbahani, Mehdi A1 - Florquin, S. A1 - Weis, J. A1 - Staat, Manfred A1 - Tolba, R. H. T1 - Hypothermic machine perfusion of kidney grafts: which pressure is preferred JF - Annals of Biomedical Engineering. 39 (2011), H. 3 Y1 - 2011 SN - 1573-9686 SP - 1051 EP - 1059 PB - Springer CY - Berlin ER - TY - CHAP A1 - Droszez, Anna A1 - Sanno, Maximilian A1 - Goldmann, Jan-Peter A1 - Albracht, Kirsten A1 - Brüggemann, Gerd-Peter A1 - Braunstein, Bjoern T1 - Differences between take-off behavior during vertical jumps and two artistic elements T2 - 34th International Conference of Biomechanics in Sport, Tsukuba, Japan, July 18-22, 2016 Y1 - 2016 SN - 1999-4168 SP - 577 EP - 580 ER - TY - THES A1 - Duong, Minh Tuan T1 - Hyperelastic modeling and soft-tissue growth integrated with the smoothed finite element method - SFEM Y1 - 2015 N1 - Aachen, Techn. Hochsch., Diss., 2014 PB - RWTH Aachen University ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Jung, Alexander A1 - Frotscher, Ralf A1 - Staat, Manfred ED - Papadrakakis, M. T1 - A 3D electromechanical FEM-based model for cardiac tissue T2 - ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5–10 June 2016 Y1 - 2016 N1 - revised after the conference P11367 ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, N. H. A1 - Staat, Manfred T1 - Modeling and simulation of a growing mass by the Smoothed Finite Element Method (SFEM) T2 - Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon Y1 - 2015 SP - 1 EP - 4 PB - RWTH Aachen University CY - Aachen ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Hunyh A1 - Staat, Manfred T1 - Finite Element Implementation of a 3D Fung-type Model T2 - ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012 Y1 - 2012 SN - 978-3-85125-223-1 PB - Verlag d. Technischen Universität Graz CY - Graz ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred ED - Eberhardsteiner, J. T1 - Numerical stability enhancement of modeling hyperelastic materials T2 - Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Y1 - 2012 N1 - 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Vienna, Austria, September 10-14, 2012 ER - TY - JOUR A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred T1 - Physical response of hyperelastic models for composite materials and soft tissues JF - Asia pacific journal on computational engineering Y1 - 2015 U6 - http://dx.doi.org/10.1186/s40540-015-0015-x SN - 2196-1166 VL - 2 IS - 3 (December 2015) SP - 1 EP - 18 ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred T1 - Physical response of hyperelastic models for composite materials and soft tissues T2 - Advances in Composite Material Y1 - 2017 SN - 978-1-61896-300-0 (Hardcover), 978-1-61896-299-7 (Paperback) N1 - Chapter 5 PB - Scientific Research Publishing CY - Wuhan ER - TY - JOUR A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Tran, Thanh Ngoc A1 - Tolba, R. H. A1 - Staat, Manfred T1 - Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen JF - International biomechanics Y1 - 2015 U6 - http://dx.doi.org/10.1080/23335432.2015.1049295 SN - 2333-5432 VL - Vol. 2 IS - Iss. 1 SP - 79 EP - 88 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Seifarth, Volker A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries. KW - Mechanical simulation KW - Growth modelling KW - Ureter KW - Bladder KW - Reconstruction Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_9 SP - 209 EP - 232 PB - Springer CY - Singapore ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Staat, Manfred ED - Onate, E. T1 - A face-based smoothed finite element method for hyperelastic models and tissue growth T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona Y1 - 2014 SP - 1 EP - 12 ER - TY - JOUR A1 - Eijck, Lambert van A1 - Demmel, Franz A1 - Artmann, Gerhard A1 - Stadtler, Andreas Maximilian T1 - Macromolecular dynamics in red blood cells investigated using neutron spectroscopy JF - Journal of the Royal Society Interface Y1 - 2011 SN - 1742-5689 VL - 8 IS - 57 SP - 590 EP - 600 PB - The Royal Society CY - London ER - TY - CHAP A1 - ElBashir, Rasha A1 - Digel, Ilya T1 - Effect of nitric oxide gas on hydrogels : [abstract] N2 - The results support our theory that the NO gas has an influence in increasing the translational diffusion of hydrogels and it accelerates the melting process of the gels. KW - Stickstoffmonoxid KW - Hydrogel KW - nitric oxide gas KW - hydrogel Y1 - 2009 ER - TY - BOOK A1 - Elsaesser, Evelyn A1 - Klebinggat, Michael A1 - Kuhn, Wilfried A1 - Michielsens, Constant A1 - Pauels, Willibert A1 - Popkes, Enno E. A1 - Schneider, Elke A1 - Laack, Walter van A1 - Warven, Rinus van ED - Laack, Walter van T1 - Schnittstelle Tod - Ist die Menschheit zu retten ohne Vertrauen auf ein Danach Y1 - 2024 SN - 978-3-936624-58-8 N1 - 8. Tagungsband zum NTE-Seminar in Aachen am, 11.11.2023 PB - van Laack Buchverlag CY - Aachen ER - TY - JOUR A1 - Emons, H. A1 - Baade, A. A1 - Schöning, Michael Josef T1 - Voltammetric determination of heavy metals in microvolumes of rain water JF - Electroanalysis. 12 (2000), H. 15 Y1 - 2000 SN - 1040-0397 SP - 1171 EP - 1176 ER - TY - JOUR A1 - Emons, H. A1 - Glück, O. A1 - Hüllenkremer, B. A1 - Schöning, Michael Josef T1 - Voltohmmetry as an alternative detection method at polycrystalline metal film electrodes JF - Electroanalysis. 13 (2001), H. 8-9 Y1 - 2001 SN - 1040-0397 SP - 677 EP - 680 ER - TY - JOUR A1 - Emons, H. A1 - Glück, O. A1 - Schöning, Michael Josef T1 - Voltohmmetry – An alternative detection principle at ultrathin metal electrodes in solution JF - Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler Y1 - 2001 SN - 1-56677-351-2 N1 - International Symposium: Chemical and Biological Sensors and Analytical Methods ; (2 : 2001.) SP - 1 EP - 3 PB - Electrochemical Society CY - Pennington, NJ ER - TY - JOUR A1 - Emons, H. A1 - Hüllenkremer, B. A1 - Schöning, Michael Josef T1 - Detection of metal ions in aqueous solutions by voltohmmetry JF - Fresenius' Journal of Analytical Chemistry. 369 (2001), H. 1 Y1 - 2001 SN - 0937-0633 SP - 42 EP - 46 ER - TY - THES A1 - Engelmann, Ulrich M. T1 - Assessing magnetic fluid hyperthermia : magnetic relaxation simulation, modeling of nanoparticle uptake inside pancreatic tumor cells and in vitro efficacy Y1 - 2019 SN - 978-3-945954-58-4 N1 - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2019 PB - Infinite Science Publishing CY - Lübeck ER - TY - BOOK A1 - Engelmann, Ulrich M. T1 - Zielführend moderieren N2 - In der Teamarbeit wird Moderation zum Erfolgsfaktor, der jedoch häufig unterschätzt wird. Ausgehend vom persönlichen Kompetenzniveau verknüpft dieses Buch Grundlagen und Methoden zu Wegen, um Ihre persönliche Entwicklung individuell zu begleiten: Neulinge finden hilfreiche Checklisten und Basistechniken für ihre ersten Moderationen, Fortgeschrittene wertvolle Praxistipps und Methoden für den Ausbau ihrer Moderationskompetenz. Profis schließlich genießen eine raffinierte Aussicht auf weniger bekannte Techniken und neue Anwendungen. Weiterführende Exkurse zum Meeting-Management und zur Online-Moderation runden den Anwendungshorizont ab. Ob in Beruf, Studium oder Ehrenamt – derart ausgestattet gelingen Ihre eigene sowie die Entwicklung Ihres Teams durch zielführende Moderationen. Y1 - 2022 SN - 9783838556895 U6 - http://dx.doi.org/10.36198/9783838556895 PB - UVK Verlag CY - Stuttgart ER - TY - CHAP A1 - Engelmann, Ulrich M. ED - Lindinger, Markus ED - Bartsch, Oliver T1 - Moderationsexpertise – Onlinemoderation T2 - IT-Servicemanagement N2 - Damit Sie auch in den immer häufiger werdenden Onlineveranstaltungen als Moderator gut bestehen, sollten Sie wissen, was bei der Onlinemoderation im Besonderen zu beachten ist. In diesem dritten Teil der Beitragsserie erfahren Sie, warum online anders als offline ist. Die technischen Möglichkeiten werden vorgestellt und auch wie diese zu nutzen sind. Schließlich erhalten Sie Tipps, die Sie beim Sprechen online beachten sollten. Y1 - 2023 SN - 978-3-8249-1154-7 SP - Kapitel 05532 PB - TÜV-Verlag CY - Köln ER - TY - CHAP A1 - Engelmann, Ulrich M. A1 - Baumann, Martin ED - Herbig, Nicola ED - Poppelreuter, Stefan T1 - Moderationsexpertise für QMBs – das Mindset T2 - Qualitätsmanagement im Gesundheitswesen N2 - Teamsitzungen, Arbeitsgruppentreffen, Kickoffs und Meetings – sie alle werden mit dem Ziel durchgeführt, innerhalb einer vorgegebenen Zeitspanne ein gemeinsames Arbeitsziel zu erreichen. Damit die Zielerreichung auch bei komplexeren Arbeitsaufträgen nicht vom Zufall abhängt, empfiehlt es sich, die Leitung des Ablaufs einem Moderator zu übertragen. In diesem Beitrag einer mehrteiligen Serie wird beschrieben, über welches Mindset der Moderator verfügen sollte, welche grundsätzlichen Methoden hilfreich sind und was bei der Onlinemoderation im Besonderen zu beachten ist. Y1 - 2022 SN - 978-3-8249-0714-4 SP - Kapitel 10814 PB - TÜV-Verlag CY - Köln ET - 59. Update ER - TY - CHAP A1 - Engelmann, Ulrich M. A1 - Baumann, Martin ED - Herbig, Nicola ED - Poppelreuter, Stefan T1 - Moderationsexpertise für QMBs – die Methoden T2 - Qualitätsmanagement im Gesundheitswesen N2 - Damit Sie als Moderator effektiv und professionell moderieren können, sollten Sie die entsprechenden Methoden kennen. Mit den richtigen Methoden können Sie Diskussionen leiten, Konflikte lösen, die Teilnehmer motivieren und dafür sorgen, dass die Ziele der Veranstaltung erreicht werden. Außerdem helfen sie Ihnen, eine positive Atmosphäre zu schaffen und das Interesse der Teilnehmer zu halten. In diesem zweiten Beitrag der mehrteiligen Serie lernen Sie die grundsätzlichen Methoden kennen, um erfolgreiche Teamsitzungen, Arbeitsgruppentreffen, Kick-offs und Meetings durchzuführen. Y1 - 2023 SN - 978-3-8249-0714-4 SP - Kapitel 10815 PB - TÜV-Verlag CY - Köln ET - 60. Update ER - TY - CHAP A1 - Engelmann, Ulrich M. A1 - Baumann, Martin ED - Thomann, Hermann ED - Träger, Thomas T1 - Moderationsexpertise für QMBs – das Mindset T2 - Qualitätsmanagement in Dienstleistungsunternehmen N2 - Teamsitzungen, Arbeitsgruppentreffen, Kickoffs und Meetings – sie alle werden mit dem Ziel durchgeführt, innerhalb einer vorgegebenen Zeitspanne ein gemeinsames Arbeitsziel zu erreichen. Damit die Zielerreichung auch bei komplexeren Arbeitsaufträgen nicht vom Zufall abhängt, empfiehlt es sich, die Leitung des Ablaufs einem Moderator zu übertragen. In diesem Beitrag einer mehrteiligen Serie wird beschrieben, über welches Mindset der Moderator verfügen sollte, welche grundsätzlichen Methoden hilfreich sind und was bei der Onlinemoderation im Besonderen zu beachten ist. Y1 - 2023 SN - 978-3-8249-0473-0 SP - Kapitel 08630 PB - TÜV-Verlag CY - Köln ER - TY - CHAP A1 - Engelmann, Ulrich M. A1 - Baumann, Martin ED - Lindinger, Markus ED - Bartsch, Oliver T1 - Moderationsexpertise - das Mindset T2 - IT-Servicemanagement N2 - Teamsitzungen, Arbeitsgruppentreffen, Kickoffs und Meetings – sie alle werden mit dem Ziel durchgeführt, innerhalb einer vorgegebenen Zeitspanne ein gemeinsames Arbeitsziel zu erreichen. Damit die Zielerreichung auch bei komplexeren Arbeitsaufträgen nicht vom Zufall abhängt, empfiehlt es sich, die Leitung des Ablaufs einem Moderator zu übertragen. In diesem Beitrag einer dreiteiligen Serie wird beschrieben, über welches Mindset der Moderator verfügen sollte, welche grundsätzlichen Methoden hilfreich sind und was bei der Onlinemoderation im Besonderen zu beachten ist. Y1 - 2023 SN - 978-3-8249-1154-7 SP - Kapitel 05530 PB - TÜV-Verlag CY - Köln ET - 54. Update ER - TY - CHAP A1 - Engelmann, Ulrich M. A1 - Baumann, Martin ED - Thomann, Hermann ED - Träger, Thomas T1 - Moderationsexpertise für QMBs – die Methoden T2 - Qualitätsmanagement in Dienstleistungsunternehmen N2 - Damit Sie als Moderator effektiv und professionell moderieren können, sollten Sie die entsprechenden Methoden kennen. Mit den richtigen Methoden können Sie Diskussionen leiten, Konflikte lösen, die Teilnehmer motivieren und dafür sorgen, dass die Ziele der Veranstaltung erreicht werden. Außerdem helfen sie Ihnen, eine positive Atmosphäre zu schaffen und das Interesse der Teilnehmer zu halten. In diesem zweiten Beitrag der mehrteiligen Serie lernen Sie die grundsätzlichen Methoden kennen, um erfolgreiche Teamsitzungen, Arbeitsgruppentreffen, Kick-offs und Meetings durchzuführen. Y1 - 2023 SN - 978-3-8249-0473-0 SP - Kapitel 08631 PB - TÜV-Verlag CY - Köln ER - TY - CHAP A1 - Engelmann, Ulrich M. A1 - Baumann, Martin ED - Lindinger, Markus ED - Bartsch, Oliver T1 - Moderationsexpertise – die Methoden T2 - IT-Servicemanagement N2 - Damit Sie als Moderator effektiv und professionell moderieren können, sollten Sie die entsprechenden Methoden kennen. Mit den richtigen Methoden können Sie Diskussionen leiten, Konflikte lösen, die Teilnehmer motivieren und dafür sorgen, dass die Ziele der Veranstaltung erreicht werden. Außerdem helfen sie Ihnen, eine positive Atmosphäre zu schaffen und das Interesse der Teilnehmer zu halten. In diesem zweiten Beitrag der mehrteiligen Serie lernen Sie die grundsätzlichen Methoden kennen, um erfolgreiche Teamsitzungen, Arbeitsgruppentreffen, Kick-offs und Meetings durchzuführen. Y1 - 2023 SN - 978-3-8249-1154-7 SP - Kapitel 05531 PB - TÜV-Verlag CY - Köln ET - 54. Update ER - TY - CHAP A1 - Engelmann, Ulrich M. A1 - Baumann, Martin ED - Herbig, Nicola ED - Poppelreuter, Stefan T1 - Moderationsexpertise für QMBs – Onlinemoderation T2 - Qualitätsmanagement im Gesundheitswesen N2 - Damit Sie auch in den immer häufiger werdenden Onlineveranstaltungen als Moderator gut bestehen, sollten Sie wissen, was bei der Onlinemoderation im Besonderen zu beachten ist. In diesem dritten Teil der Beitragsserie erfahren Sie, warum online anders als offline ist. Die technischen Möglichkeiten werden vorgestellt und auch wie diese zu nutzen sind. Schließlich erhalten Sie Tipps, die Sie beim Sprechen online beachten sollten. Y1 - 2023 SN - 978-3-8249-0714-4 SP - Kapitel 10816 PB - TÜV-Verlag CY - Köln ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Buhl, Eva Miriam A1 - Baumann, Martin A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia JF - Current Directions in Biomedical Engineering Y1 - 2017 U6 - http://dx.doi.org/10.1515/cdbme-2017-0096 SN - 2364-5504 VL - 3 IS - 2 SP - 457 EP - 460 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Buhl, Eva Miriam A1 - Draack, Sebastian A1 - Viereck, Thilo A1 - Frank, A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications JF - IEEE Magnetic Letters N2 - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy. Y1 - 2018 U6 - http://dx.doi.org/10.1109/LMAG.2018.2879034 SN - 1949-307X VL - 9 IS - Article number 8519617 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Pourshahidi, Mohammad Ali A1 - Shalaby, Ahmed A1 - Krause, Hans-Joachim T1 - Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation JF - Journal of Magnetism and Magnetic Materials N2 - Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles’ magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing. Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.jmmm.2022.169965 SN - 0304-8853 VL - 563 IS - In progress, Art. No. 169965 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Roeth, Anjali A.J. A1 - Eberbeck, Dietmar A1 - Buhl, Eva Miriam A1 - Neumann, Ulf Peter A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells JF - Scientific Reports N2 - Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95% was achieved by depositing an intracellular total thermal energy with about 50% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65% after MNP were internalized inside cells. Y1 - 2018 U6 - http://dx.doi.org/10.1038/s41598-018-31553-9 SN - 2045-2322 VL - 8 IS - 1 SP - Article number 13210 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Seifert, Julian A1 - Mues, Benedikt A1 - Roitsch, Stefan A1 - Ménager, Christine A1 - Schmidt, Annette M. A1 - Slabu, Ioana T1 - Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels JF - Journal of Magnetism and Magnetic Materials Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.jmmm.2018.09.113 SN - 0304-8853 VL - 471 IS - 1 SP - 486 EP - 494 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Shalaby, Ahmed A1 - Shasha, Carolyn A1 - Krishnan, Kannan M. A1 - Krause, Hans-Joachim T1 - Comparative modeling of frequency mixing measurements of magnetic nanoparticles using micromagnetic simulations and Langevin theory JF - Nanomaterials N2 - Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90% of the frequency mixing magnetic response signal is generated by the largest 10% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory. KW - Magnetic nanoparticles KW - Frequency mixing magnetic detection KW - Langevin theory KW - Micromagnetic simulation KW - Nonequilibrium dynamics Y1 - 2021 SN - 2079-4991 U6 - http://dx.doi.org/10.3390/nano11051257 N1 - This article belongs to the Special Issue Applications and Properties of Magnetic Nanoparticles VL - 11 IS - 5 SP - 1 EP - 16 PB - MDPI CY - Basel ER - TY - CHAP A1 - Engelmann, Ulrich M. A1 - Shasha, Carolyn A1 - Slabu, Ioana T1 - Magnetic nanoparticle relaxation in biomedical application: focus on simulating nanoparticle heating T2 - Magnetic nanoparticles in human health and medicine Y1 - 2021 SN - 978-1-119-75467-1 SP - 327 EP - 354 PB - Wiley-Blackwell CY - Hoboken, New Jeersey ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Shasha, Carolyn A1 - Teeman, Eric A1 - Slabu, Iona A1 - Krishnan, Kannan M. T1 - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation JF - Journal of Magnetism and Magnetic Materials Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.jmmm.2018.09.041 SN - 0304-8853 VL - 471 IS - 1 SP - 450 EP - 456 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Simsek, Beril A1 - Shalaby, Ahmed A1 - Krause, Hans-Joachim T1 - Key contributors to signal generation in frequency mixing magnetic detection (FMMD): an in silico study JF - Sensors N2 - Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled Néel–Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dc > 25 nm nm with narrow size distributions (σ < 0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays. KW - key performance indicators KW - magnetic biosensing KW - coupled Néel–Brownian relaxation dynamics KW - frequency mixing magnetic detection KW - magnetic relaxation KW - micromagnetic simulation KW - magnetic nanoparticles Y1 - 2024 U6 - http://dx.doi.org/10.3390/s24061945 SN - 1424-8220 N1 - This article belongs to the Special Issue "Advances in Magnetic Sensors and Their Applications" VL - 24 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Erbayraktar, Zubeyde A1 - Yilmaz, Osman A1 - Temiz Artmann, Aysegül A1 - Cehreli, Ruksan A1 - Coker, Canan T1 - Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus JF - Biological Trace Element Research Y1 - 2007 SN - 1559-0720 VL - 118 IS - 3 SP - 217 EP - 226 ER - TY - JOUR A1 - Erki, I. A1 - Kleines, H. A1 - Ziemons, Karl A1 - Zwoll, K. ED - Lehmann, Thomas T1 - Interaktives System zur Darstellung funktionaler Bilddaten JF - Bildverarbeitung für die Medizin : Algorithmen - Systeme - Anwendungen Y1 - 1997 SN - 3-86073-519-5 N1 - Proceedings des Aachener Workshops am 8. u. 9. November 1996 ; PP_002 Posterpräsentation SP - 249 EP - 254 PB - Verl. der. Augustinus-Buchh. CY - Aachen ER - TY - JOUR A1 - Ermelenko, Y. A1 - Yoshinobu, T A1 - Mourzina, Y. A1 - Levichev, S. A1 - Furuichi, K. A1 - Vlasov, Y. A1 - Schöning, Michael Josef A1 - Iwasaki, H. T1 - Photocurable membranes for ion-selective light-addressable potentiometric sensors JF - Sensors and Actuators B. 85 (2002), H. 1-2 Y1 - 2002 SN - 0925-4005 SP - 79 EP - 85 ER - TY - JOUR A1 - Ermelenko, Y. A1 - Yoshinobu, T. A1 - Mourzina, Y. A1 - Furuichi, K. A1 - Iwasaki, H. A1 - Vlasov, Y. A1 - Schöning, Michael Josef T1 - Technology of photocurable polymeric membranes for integrated LAPS JF - Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan Y1 - 2001 N1 - Chemical sensors; 17.2001 Suppl. B; East Asian Conference on Chemical Sensors ; (5, 2001; Nagasaki) SP - 66 EP - 68 PB - Japan Association of Chemical Sensors CY - Kasuga, Fukuoka-ken ER - TY - JOUR A1 - Ermelenko, Y. A1 - Yoshinobu, T. A1 - Mourzina, Y. A1 - Furuichi, K. A1 - Levichev, S. A1 - Vlasov, Y. A1 - Schöning, Michael Josef A1 - Iwasaki, H. T1 - Lithium sensor based on the laser scanning semiconductor transducer JF - Analytica Chimica Acta. 459 (2002), H. 1 Y1 - 2002 SN - 0378-4304 SP - 1 EP - 9 ER - TY - JOUR A1 - Ermelenko, Y. A1 - Yoshinobu, T. A1 - Mourzina, Y. A1 - Schöning, Michael Josef A1 - Furuichi, K. A1 - Levichev, S. A1 - Vlasov, Y. A1 - Iwasaki, H. T1 - The double K+/Ca2+ sensor based on laser scanned silicon transducer (LSST) for multicomponent analysis JF - Talanta. 59 (2003), H. 4 Y1 - 2003 SN - 0039-9140 SP - 785 EP - 795 ER - TY - JOUR A1 - Ermelenko, Y. A1 - Yoshinobu, T. A1 - Mourzina, Y. A1 - Schöning, Michael Josef A1 - Vlasov, Y. A1 - Iwasaki, H. T1 - The hybrid K+/Ca2+ sensor based on laser scanned silicon transducer for multi-component analysis JF - Proceedings of ICAS 2001, IUPAC [3rd] International Congress on Analytical Sciences 2001 : August 6 - 10, 2001, Waseda University, Tokyo Y1 - 2002 N1 - International Congress on Analytical Sciences <2001, Tokyo> ; International Union of Pure and Applied Chemistry. Pure and applied chemistry ; 73,10. ; Analytical sciences ; 17.2001, special issue SP - i777 EP - i780 PB - Japan Society for Analytical Chemistry CY - Tokyo ER - TY - CHAP A1 - Ermelenko, Y. A1 - Yoshinobu, T. A1 - Mourzina, Y. A1 - Schöning, Michael Josef A1 - Vlasov, Y. A1 - Iwasaki, H. T1 - A multisensor based on laser scanned silicon transducer (LSST): development and properties T2 - Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimarães, Portugal, September 21 - 24, 2003 Y1 - 2003 SP - 72 EP - 73 ER - TY - JOUR A1 - Ermolaev, A.P. A1 - Nivokov, I.A. A1 - Melnikova, L.I. A1 - Kotliar, Konstantin T1 - Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой T1 - Comparative characteristics of the chemical composition of vitreal contents of cadaver eyes and eyes with terminal refractory glaucoma JF - Vestnik oftalmologii N2 - Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP. Y1 - 2018 U6 - http://dx.doi.org/10.17116/oftalma2018134051195 VL - 5 IS - 2 SP - 195 EP - 201 PB - Media Sfera CY - Moskau ER - TY - JOUR A1 - Ermolaev, AP A1 - Erichev, VP A1 - Antonov, AA A1 - Grigoryan, GL A1 - Kotliar, Konstantin A1 - Levitsky, YV A1 - Hderi, K A1 - Mazurova, YV T1 - Assessing retinal photosensitivity in patients with central vision impairment using a portable perimeter (a preliminary report) JF - Vestnik oftalmologii Y1 - 2019 U6 - http://dx.doi.org/10.17116/oftalma201913503146 N1 - Abstract in Englisch VL - 135 IS - 3 SP - 46 EP - 54 ER - TY - JOUR A1 - Ermolenko, Y. E. A1 - Yoshinobu, T. A1 - Mourzina, Y. G. A1 - Vlasov, Y. G. A1 - Schöning, Michael Josef A1 - Iwasaki, H. T1 - Laserscanned transducer (LSST) as a multisensor system JF - Sensors and Actuators B. 103 (2004), H. 1-2 Y1 - 2004 SN - 0925-4005 SP - 457 EP - 462 ER - TY - JOUR A1 - Ermolenko, Y.E. A1 - Vlasov, Y.G. A1 - Kolodnikov, V.V. A1 - Shabaldkin, D. A. A1 - Kloock, Joachim P. A1 - Schöning, Michael Josef T1 - Diffusion of radioactive tracers (204Tl, 110mAg) and ionic conductivity in membrane materials for the chemical sensors JF - Advances in nuclear and radiochemistry : extended abstracts of papers presented at the Sixth International Conference on Nuclear and Radiochemistry (NRC-6), 29 August to 3 September 2004, Aachen, Germany ; in cooperation with University of Cologne, GDCh, FECS, OECD-NEA and IAEA / Syed M. Qaim ... (eds.). Y1 - 2004 SN - 3893363629 N1 - Schriften des Forschungszentrums Jülich Reihe Allgemeines und Interdisziplinäres ; 3. International Conference on Nuclear and Radiochemistry ; (6, 2004, Aachen) SP - 483 EP - 485 PB - Forschungszentrum Jülich, Zentralbibliothek CY - Jülich ER - TY - CHAP A1 - Eschler, Eric A1 - Wozniak, Felix A1 - Richter, Christoph A1 - Drechsler, Klaus T1 - Materialanalyse an lokal verstärkten Triaxialgeflechten T2 - Leichtbau in Forschung und industrieller Anwendung von der Nano- bis zur Makroebene, LLC, Landshuter Leichtbau-Colloquium, 9 Y1 - 2019 SN - 978-3-9818439-2-7 SP - 120 EP - 131 PB - Leichtbau Cluster CY - Landshut ER - TY - JOUR A1 - Eschweiler, J. A1 - Laack, Walter van A1 - Staat, Manfred T1 - Elektromyographische Untersuchungen zur Kräftigung der Oberschenkelmuskulatur mit einem myoelektrischen Stimulator nach arthroskopischen Eingriffen am Kniegelenk JF - Orthopädische Praxis. 43 (2007), H. 10 Y1 - 2007 SN - 0030-588x SP - 539 EP - 542 ER - TY - JOUR A1 - Faßbender, F. A1 - Schmitt, G. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Buß, G. A1 - Schultze, J. W. T1 - Optimization of passivation layers for corrosion protection of silicon-based microelectrode arrays JF - Sensors and Actuators B. 68 (2000), H. 1-3 Y1 - 2000 SN - 0925-4005 SP - 128 EP - 133 ER - TY - JOUR A1 - Faßbender, F. A1 - Schmitt, G. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Buß, G. A1 - Schultze, J. W. T1 - Passivation and corrosion of microsensor devices exemplified at microelectrode arrays JF - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1. Y1 - 1999 SN - 90-76699-02-X N1 - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague) SP - 953 EP - 956 CY - The Hague, The Netherlands ER - TY - JOUR A1 - Feucht, Nikolaus A1 - Schönbach, Etienne Michael A1 - Lanzl, Ines A1 - Kotliar, Konstantin A1 - Lohmann, Chris Patrick A1 - Maier, Mathias T1 - Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease JF - Clinical Ophthalmology Y1 - 2013 SN - 1177-5483 VL - 7 SP - 173 EP - 178 PB - Dove Medical Press CY - Auckland, New Zealand ER - TY - JOUR A1 - Figueroa-Miranda, Gabriela A1 - Feng, Lingyan A1 - Shiu, Simon Chi-Chin A1 - Dirkzwager, Roderick Marshall A1 - Cheung, Yee-Wai A1 - Tanner, Julian Alexander A1 - Schöning, Michael Josef A1 - Offenhäusser, Andreas A1 - Mayer, Dirk T1 - Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability JF - Sensor and Actuators B: Chemical N2 - Malaria infection remains a significant risk for much of the population of tropical and subtropical areas, particularly in developing countries. Therefore, it is of high importance to develop sensitive, accurate and inexpensive malaria diagnosis tests. Here, we present a novel aptamer-based electrochemical biosensor (aptasensor) for malaria detection by impedance spectroscopy, through the specific recognition between a highly discriminatory DNA aptamer and its target Plasmodium falciparum lactate dehydrogenase (PfLDH). Interestingly, due to the isoelectric point (pI) of PfLDH, the aptasensor response showed an adjustable detection range based on the different protein net-charge at variable pH environments. The specific aptamer recognition allows sensitive protein detection with an expanded detection range and a low detection limit, as well as a high specificity for PfLDH compared to analogous proteins. The specific feasibility of the aptasensor is further demonstrated by detection of the target PfLDH in human serum. Furthermore, the aptasensor can be easily regenerated and thus applied for multiple usages. The robustness, sensitivity, and reusability of the presented aptasensor make it a promising candidate for point-of-care diagnostic systems. Y1 - 2018 U6 - http://dx.doi.org/10.1016/j.snb.2017.07.117 SN - 0925-4005 VL - 255 IS - P1 SP - 235 EP - 243 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Fink, G. R. A1 - Marshall, J. C. A1 - Shah, N. J. A1 - Weiss, P.H. A1 - Halligan, P. W. A1 - Grosse-Ruyken, M. A1 - Ziemons, Karl A1 - Zilles, K. A1 - Freund, H. J. T1 - Line bisection judgments implicate right parietal cortex and cerebellum as assessed by fMRI JF - Neurology Y1 - 2000 SN - 1526-632X VL - 54 IS - 6 SP - 1324 EP - 1331 ER - TY - JOUR A1 - Fischer, Felix A1 - Selver, M. Alper A1 - Gezer, Sinem A1 - Dicle, Oguz A1 - Hillen, Walter T1 - Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data JF - Journal of Medical and Biological Engineering Y1 - 2015 U6 - http://dx.doi.org/10.1007/s40846-015-0097-5 SN - 2199-4757 VL - 35 IS - 6 SP - 709 EP - 723 PB - Springer CY - Berlin ER - TY - JOUR A1 - Forst, Thomas A1 - Karagiannis, E. A1 - Lübben, G. A1 - Hohberg, C. A1 - Schöndorf, T. A1 - Dikta, Gerhard A1 - Drexler, M. A1 - Morcos, M. A1 - Dänschel, W. A1 - Borchert, M. A1 - Pfützner, A. T1 - Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease JF - Atherosclerosis. 197 (2008), H. 1 Y1 - 2008 U6 - http://dx.doi.org/10.1016/j.atherosclerosis.2007.05.006 SN - 0021-9150 SP - 311 EP - 317 ER - TY - JOUR A1 - Frank, T. A1 - Buchwald, D. A1 - Pennekamp, W. A1 - Reber, D. A1 - Sponagel, Stefan A1 - Laszkovics, A. A1 - Weber, Hans-Joachim T1 - Röntgenologische Untersuchung der Strömungseigenschaften funktioneller Komponenten der Herz-Lungen-Maschine JF - Kardiotechnik. 18 (2009), H. 2 Y1 - 2009 SN - 0941-2670 N1 - gedruckt in der Bibliothek unter der Signatur 63 Z 629 SP - 31 EP - 35 ER - TY - CHAP A1 - Frotscher, Ralf A1 - Duong, Minh Tuan A1 - Staat, Manfred T1 - Simulating beating cardiomyocytes with electromechanical coupling T2 - II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.) Y1 - 2015 SP - 1 EP - 2 ER - TY - CHAP A1 - Frotscher, Ralf A1 - Goßmann, Matthias A1 - Raatschen, Hans-Jürgen A1 - Temiz Artmann, Aysegül A1 - Staat, Manfred T1 - Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM T2 - Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45) N2 - We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEM for plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments. Y1 - 2015 SN - 978-3-319-02534-6 ; 978-3-319-02535-3 SP - 187 EP - 212 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Frotscher, Ralf A1 - Goßmann, Matthias A1 - Temiz Artmann, Aysegül A1 - Staat, Manfred T1 - Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM T2 - 1st International Conference "Shell and Membrane Theories in Mechanics and Biology: From Macro- to Nanoscale Structures", Minsk, Belarus, Sept. 16-20, 2013 Y1 - 2013 SN - 978-985-553-135-8 SP - 165 EP - 167 PB - Verl. d. Weißruss. Staatl. Univ. CY - Minsk ER - TY - CHAP A1 - Frotscher, Ralf A1 - Koch, Jan-Peter A1 - Raatschen, Hans-Jürgen A1 - Staat, Manfred ED - Onate, E. T1 - Evaluation of a computational model for drug action on cardiac tissue T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona Y1 - 2014 SP - 1 EP - 12 ER - TY - JOUR A1 - Frotscher, Ralf A1 - Koch, Jan-Peter A1 - Staat, Manfred T1 - Computational investigation of drug action on human-induced stem cell derived cardiomyocytes JF - Journal of biomechanical engineering Y1 - 2015 U6 - http://dx.doi.org/10.1115/1.4030173 SN - 1528-8951 (E-Journal); 0148-0731 (Print) VL - Vol. 137 IS - iss. 7 SP - 071002-1 EP - 071002-7 PB - ASME CY - New York ER - TY - JOUR A1 - Frotscher, Ralf A1 - Muanghong, Danita A1 - Dursun, Gözde A1 - Goßmann, Matthias A1 - Temiz Artmann, Aysegül A1 - Staat, Manfred T1 - Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue JF - Journal of Biomechanics N2 - We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures. KW - hiPS cardiomyocytes KW - Homogenization KW - Hodgkin–Huxley models KW - Frequency adaption KW - Electromechanical modeling KW - Drug simulation KW - Computational biomechanics KW - Cardiac tissue Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.jbiomech.2016.01.039 SN - 0021-9290 (Print) SN - 1873-2380 (Online) VL - 49 IS - 12 SP - 2428 EP - 2435 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Frotscher, Ralf A1 - Raatschen, Hans-Jürgen A1 - Staat, Manfred ED - Eberhardsteiner, J. T1 - Application of an edge-based smoothed finite element method on geometrically non-linear plates of non-linear material T2 - Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Y1 - 2012 N1 - 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Vienna, Austria, September 10-14, 2012 ER - TY - CHAP A1 - Frotscher, Ralf A1 - Raatschen, Hans-Jürgen A1 - Staat, Manfred ED - Holzapfel, Gerhard A. T1 - Effectiveness of the edge-based smoothed finite element method applied to soft biological tissues T2 - ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012 Y1 - 2012 SN - 978-3-85125-223-1 PB - Verlag d. Technischen Universität Graz CY - Graz ER - TY - JOUR A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Stresses produced by different textile mesh implants in a tissue equivalent JF - BioNanoMaterials N2 - Two single-incision mini-slings used for treating urinary incontinence in women are compared with respect to the stresses they produce in their surrounding tissue. In an earlier paper we experimentally observed that these implants produce considerably different stress distributions in a muscle tissue equivalent. Here we perform 2D finite element analyses to compare the shear stresses and normal stresses in the tissue equivalent for the two meshes and to investigate their failure behavior. The results clearly show that the Gynecare TVT fails for increasing loads in a zipper-like manner because it gradually debonds from the surrounding tissue. Contrary to that, the tissue at the ends of the DynaMesh-SIS direct may rupture but only at higher loads. The simulation results are in good agreement with the experimental observations thus the computational model helps to interpret the experimental results and provides a tool for qualitative evaluation of mesh implants. Y1 - 2014 U6 - http://dx.doi.org/10.1515/bnm-2014-0003 SN - 2191-4672 (E-Journal); 2193-066X (E-Journal); 0011-8656 (Print); 1616-0177 (Print); 2193-0651 (Print) VL - 15 IS - 1-2 SP - 25 EP - 30 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - An electromechanical model for cardiac tissue constructs T2 - Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon Y1 - 2015 SP - 1 EP - 4 PB - RWTH Aachen University CY - Aachen ER - TY - CHAP A1 - Frotscher, Ralf A1 - Staat, Manfred ED - Nithiarasu, Perumal T1 - Homogenization of a cardiac tissue construct T2 - CMBE15 : 4th International Conference on Computational & Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; École Normale Supérieure de Cachan ; Cachan (Paris), France Y1 - 2015 SN - 2227-9385 N1 - Konferenzband unter: http://www.compbiomed.net/getfile.php?type=12/site_documents&id=Proceedings_2227-9385_compressed.pdf SP - 645 EP - 648 PB - CMBE CY - [s.l.] ER - TY - CHAP A1 - Frotscher, Ralf A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_10 SP - 233 EP - 250 PB - Springer CY - Singapore ER - TY - JOUR A1 - Fuest, Matthias A1 - Kotliar, Konstantin A1 - Walter, Peter A1 - Plange, Niklas T1 - Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry JF - Ophthalmic and physiological optics Y1 - 2014 U6 - http://dx.doi.org/10.1111/opo.12134 SN - 1475-1313 (E-Journal); 0275-5408 (Print) N1 - Special Issue: The Ageing Visual System VL - 34 IS - 4 SP - 438 EP - 444 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Furuichi, K. A1 - Yoshinobu, T. A1 - Ermelenko, T. A1 - Mourzina, Y. A1 - Iwasaki, H. A1 - Schöning, Michael Josef T1 - Simultaneous visualization of multiple ions by the chemical imaging sensor JF - Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan Y1 - 2001 N1 - Chemical sensors; 17.2001 Suppl. B; East Asian Conference on Chemical Sensors ; (5, 2001; Nagasaki) SP - 399 EP - 401 PB - Japan Association of Chemical Sensors CY - Kasuga, Fukuoka-ken ER -