TY  - JOUR
A1  - Hillen, Walter
T1  - RHO-RHO production by two photon scattering. TASSO Collaboration
JF  - Physics Letters B. 97 (1980), H. 3-4
Y1  - 1980
SN  - 0370-2693
SP  - 448
EP  - 452
ER  - 
TY  - JOUR
A1  - Hillen, Walter
T1  - Energy scan for narrow states in e+e− annihilation at C.M. energies between 29.90 and 31.46 GeV. TASSO Collaboration
JF  - Physics Letters B. 88 (1979), H. 1-2
Y1  - 1979
SN  - 0370-2693
SP  - 199
EP  - 202
ER  - 
TY  - JOUR
A1  - Hillen, Walter
T1  - Properties of hadron final states in e+e− annihilation at 13 GeV and 17 GeV center of mass energies. TASSO Collaboration
JF  - Physics Letters B. 83 (1979), H. 2
Y1  - 1979
SN  - 0370-2693
SP  - 261
EP  - 266
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Alper Selver, M.
A1  - Fischer, Felix
A1  - Kuntalp, Mehmet
T1  - A software tool for interactive generation, representation, and systematical storage of transfer functions for 3D medical images / Alper Selver, M. ; Fischer, Felix ; Kuntalp, Mehmet ; Hillen, Walter
JF  - Computer Methods and Programs in Biomedicine. 86 (2007), H. 3
Y1  - 2007
SN  - 0169-2607
SP  - 270
EP  - 280
PB  - -
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Barry, J. C.
A1  - Pongs, U. M.
T1  - Algorithm for Purkinje Image I and IV and Limbus Centre Location. Barry, J. C.; Pongs, U. M.; Hillen, W.
JF  - Computers in Biology and Medicine. 27 (1997), H. 6
Y1  - 1997
SN  - 0010-4825
SP  - 515
EP  - 531
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Eckenbach, W.
A1  - Quadflieg, Peter
A1  - Zaengel, Thomas T.
T1  - Signal-to-noise performance of a CsI fluorescent screen
JF  - Medical Imaging V: Image physics
Y1  - 1991
SN  - 0-8194-0538-8
N1  - Proceedings of SPIE ;  1443
SP  - 120
EP  - 131
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Fischer, Felix
T1  - Farbanalyse von gebackenen oder frittierten Nahrungsmitteln und Vorhersage des Acrylamid-Wertes
JF  - 10. Workshop Farbbildverarbeitung : Elektronische Ressource : 7.-8. Oktober 2004, Koblenz = 10th Workshop Color Image Processing / Detlev Droege ... Hrsg.
Y1  - 2004
SN  - 389959245X
N1  - Workshop Farbbildverarbeitung <10, 2004, Koblenz>
SP  - 133
EP  - 148
PB  - Der Andere Verl.
CY  - Tönning [u.a.]
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Fischer, Felix
A1  - Paulus, Dietrich
T1  - 3D Presentation States: Parametrisierung und Speicherung der 3D-Darstellung von segmentierten medizinischen Volumendaten / Fischer, Felix ; Hillen, Walter ; Paulus, Dietrich
JF  - Biomedizinische Technik. 52 (2007), H. Ergänzungsband
Y1  - 2007
SN  - 0939-4990
N1  - BMT 2007, 41. Jahrestagung der DGBMT - Deutschen Gesellschaft für Biomedizinische Technik im VDE, Aachen, DE, 26.-29. Sep, 2007
SP  - 1
EP  - 2
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Jansen, N.
A1  - Unglauben, F.
A1  - Indefrey, R.
T1  - Multimediale Darstellung und Verarbeitung medizinischer Bilddaten in Rechnernetzen.
JF  - Bildverarbeitung für die Medizin 1998 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops am 26. und 27. März 1998 in Aachen / Thomas Lehmann ... (Hrsg.)
Y1  - 1998
SN  - 3540638857
N1  - Workshop Bildverarbeitung für die Medizin ; <1998, Aachen>  <a href="http://okeanos-www.hbz-nrw.de/F?func=service&doc_library=HBZ01&doc_number=003322007&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA">Inhaltsverzeichnis</a>
SP  - 373
EP  - 377
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Lehmann, T.
A1  - Horn, H.
A1  - Schmitt, W.
T1  - IDEFIX - Identifizierung dentaler Fixturen mit morphologischen Filtern. Lehmann, T.; Horn, H.; Schmitt, W., Hillen, W.; Spitzer, K.
JF  - Bildverarbeitung für die Medizin : Algorithmen - Systeme - Anwendungen ; proceedings des Aachener Workshops am 8. und 9. November 1996 / Institut für Medizinische Informatik und Biometrie der RWTH Aachen. Hrsg. von Thomas Lehmann ...
Y1  - 1996
SN  - 3-86073-519-5
SP  - 327
EP  - 332
PB  - Verl. der Augustinus-Buchh.
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Lehmann, T.
A1  - Horn, H.
A1  - Schmitt, W.
T1  - Identification of Dental Fixtures in Intraoral X-rays. Lehmann, T.; Hillen, W.; Horn, H.; Schmitt, W.
JF  - Medical  imaging  1996 : image processing ; 12 - 15 February 1996, Newport Beach, California / Murray H. Loew ... chairs/ed.
Y1  - 1996
SN  - 0-8194-2085-9
N1  - Proceedings of SPIE; 2710
SP  - 584
EP  - 584
PB  - SPIE - The International Society for Optical Engineering
CY  - Bellingham, Wash.
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Lehmann, T.
A1  - Horn, H.
A1  - Schmitt, W.
T1  - IDEFIX - Identification of Dental Fixtures. Lehmann, T.; Hillen, W.; Horn, H.; Schmitt, W.
JF  - 5th European Congress on Dental and Maxillo-Facial Radiology : 30th Annual meeting of Working Group for Dental Radiology in the German Scientific Society for Dentistry, November 8-11, 1995, Cologne : abstracts
Y1  - 1995
N1  - European Congress on Dental and Maxillo-Facial Radiology <5, 1995, Köln>
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Rupp, S.
A1  - Schiebel, U.
A1  - Zaengel, Thomas T.
T1  - Imaging performance of a selenium-based detector for high-resolution radiography
JF  - Medical Imaging III: Image Formation
Y1  - 1989
SN  - 0-8194-0125-0
N1  - Proceedings of SPIE ; 1090
SP  - 296
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Schiebel, U.
A1  - Zaengel, T.
T1  - A selenium-based detector for digital slot-radiography
JF  - Medical Imaging II
Y1  - 1988
N1  - Proceedings of SPIE ;  914
SP  - 253
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Schiebel, U.
A1  - Zaengel, T.
T1  - Image quality in selenium-based digital radiography. Schiebel, U.; Hillen, W.; Zaengel, T.
JF  - Medical Imaging
Y1  - 1986
N1  - Proceedings of SPIE ;  626
SP  - 176
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Schiebel, U.
A1  - Zaengel, T.
T1  - Imaging performance of a digital storage phosphor system
JF  - Medical Physics. 14 (1987), H. 5
Y1  - 1987
SN  - 0094-2405
SP  - 744
EP  - 751
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Schmitt, W.
A1  - Bockemühl, J.
T1  - Signal-to-Noise Performance of a digital dental X-ray Detector
JF  - Computer  assisted  radiology : proceedings of the International Symposium on Computer and Communication Systems for Image Guided Diagnosis and Therapy / CAR '95 Berlin, June 21 - 24, 1995. Ed. by H. U. Lemke
Y1  - 1995
SN  - 3-540-59177-X
N1  - CAR <6, 1995, Berlin>
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Unglauben, F.
A1  - Indefrey, F.
T1  - Java Image Viewer zur Darstellung und Verarbeitung medizinischer Bilddaten in Rechnernetzen
JF  - Intelligente, innovative Produktentwicklung  für  die  industrielle  Praxis. Stenzel, Horst [Hrsg.]
Y1  - 2001
N1  - Forschungsverbund Multimedia an Fachhochschulen in Nordrhein-Westfalen
SP  - 23
EP  - 28
PB  - Forschungverbund Multimedia an Fachhochschulen
CY  - Köln
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Unglauben, F.
A1  - Kondring, T.
T1  - Java DICOM Viewer für die Teleradiologie. Unglauben, F.; Hillen, W.; Kondring, T.
JF  - Bildverarbeitung für die Medizin 2001 : Algorithmen, Systeme, Anwendungen ; proceedings des Workshops [Bildverarbeitung  für  die  Medizin] vom 4. - 6. März 2001 in Lübeck / Heinz Handels ... [Hrsg.]
Y1  - 2001
SN  - 3-540-41690-0
N1  - <a href="http://okeanos-www.hbz-nrw.de/F?func=service&doc_library=HBZ01&doc_number=011266628&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA">Inhaltsverzeichnis</a>; Workshop Bildverarbeitung  für  die  Medizin <2001, Lübeck>
SP  - 404
EP  - 408
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Unglauben, F.
A1  - Murdfield, M.
T1  - Study of Database Connections for a Java Medical Image Viewer. Unglauben, F.; Hillen, W.; Murdfield, M.
JF  - Intelligente, innovative Produktentwicklung  für  die  industrielle  Praxis. Blümel, Bernd; Stenzel, Horst [Hrsg.]
Y1  - 2001
N1  - Forschungsverbund Multimedia an Fachhochschulen in Nordrhein-Westfalen
SP  - 29
EP  - 33
PB  - Forschungverbund Multimedia an Fachhochschulen
CY  - Köln
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Unglauben, F.
A1  - Murdfield, M.
T1  - Evaluation of two- and three-tier database connections for a java-based medical image viewer. Unglauben, F.; Hillen, W.; Murdfield, M.
JF  - Bildverarbeitung für die Medizin 2000 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops [Bildverarbeitung  für  die  Medizin] vom 12. - 14. März 2000 in München / Alexander Horsch ... [Hrsg.]
Y1  - 2000
SN  - 3-540-67123-4
N1  - <a href="http://okeanos-www.hbz-nrw.de/F?func=service&doc_library=HBZ01&doc_number=010167928&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA">Inhaltsverzeichnis</a>; Workshop Bildverarbeitung  für  die  Medizin <2000, München>
SP  - 203
EP  - 207
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Unglauben, F.
A1  - Wirtz, G.
T1  - Architectures and Modeling of Distributed Image Information Systems. Unglauben, F.;  Hillen, W.; Wirtz, G.
JF  - Proceedings : July 14 - 18, 2002, Orlando, Florida, USA ; [jointly with the 8th International Conference on Information Systems Analysis and Synthesis (ISAS 2002)] / organized by IIIS, International Institute of Informatics  and Systemics. Ed. by Nagib Callaos
Y1  - 2002
SN  - 9800781501
N1  - World Multiconference on Systemics, Cybernetics and Informatics ; (6, 2002, Orlando, Fla.) ; International Conference on Information Systems, Analysis and Synthesis ; (8, 2002, Orlando, Fla.) ; International Institute of Informatics and Systemics ; World  Multiconference  on  Systemics,  Cybernetics  and  Informatics ; (6 : ; 2002.07.14-18 : ; Orlando, Fla.) ; SCI 2002 ; (6 : ; 2002.07.14-18 : ; Orlando, Fla.) ; International Conference on Information Systems Analysis and Synthesis ; (8 : ; 2002.07.14-18 : ; Orlando, Fla.) ; ISAS 2002 ; (8 : ; 2002.07.14-18 : ; Orlando, Fla.)
PB  - IIIS
CY  - Orlando, Fla.
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Winterschlade, T.
A1  - Krone, J.
T1  - Erkennung lokaler Bildfehler in Röntgenbildverstärkern durch parallel arbeitende Bildrechner
JF  - Parallele  Datenverarbeitung : Entwurfsmethoden, Bildverarbeitung, Simulation ; Workshop der Arbeitsgemeinschaft "Parallelverarbeitung an Fachhochschulen in NRW" am 19.6.1998 in Bochum / Jörg Krone ... (Hrsg.)
Y1  - 1998
SN  - 3-18-355310-4
N1  - Fortschritt-Berichte VDI : Reihe 10, Informatik, Kommunikationstechnik ; 553
SP  - 88
EP  - 94
PB  - VDI-Verl.
CY  - Düsseldorf
ER  - 
TY  - CHAP
A1  - Hingley, Peter
A1  - Dikta, Gerhard
T1  - Finding a well performing box-jenkins forecasting model for annualised patent filings counts
T2  - International Symposium on Forecasting, Thessaloniki, Greece, June 2019
Y1  - 2019
ER  - 
TY  - JOUR
A1  - Hirschfeld, J. A.
A1  - Lustfeld, H.
A1  - Reißel, Martin
A1  - Steffen, B.
T1  - A novel scheme for precise diagnostics and effective stabilization of currents in a fuel cell stack
JF  - International Journal of Energy Research. 34 (2010), H. 3
Y1  - 2010
SN  - 0363-907X
SP  - 293
EP  - 301
ER  - 
TY  - JOUR
A1  - Hirschfeld, J. A.
A1  - Lustfeld, H.
A1  - Reißel, Martin
A1  - Steffen, B.
T1  - Tomographic diagnostics of current distributions in a fuel cell stack
JF  - International Journal of Energy Research
Y1  - 2010
SN  - 0363-907X
VL  - 34
IS  - 3
SP  - 284
EP  - 292
ER  - 
TY  - PAT
A1  - Hofbauer, Peter
A1  - Härtel, Günter
A1  - Lösing, Karl-Heinrich
A1  - Dorner, Robert
A1  - Simonis, Rainer
A1  - Schulte, Erasmus
T1  - Brennstoffeinspritzsystem für Brennkraftmaschinen : Offenlegungsschrift DE 3833215 A1 ; Offenlegungstag: 28.12.89
N2  - Es wird ein Brennstoffeinspritzsystem für Brennkraftmaschinen vorgeschlagen, bei dem ein definiertes Teil eines fest vorgegebenen Brennstoffvolumens durch die Druckerhöhung innerhalb einer brennstoffeinschließenden Kammer eine definierte Brennstoffmenge über jeweils ein Rückschlagventil abgespritzt wird. Ein elektronisches Steuergerät berechnet die Dauer und/oder Intensität und gegebenenfalls die Impulsfolge eines zum Beispiel zur Verdampfung einer bestimmten Brennstoffmenge erforderlichen Laserimpulses. Das System kann für Ein- oder Mehrstelleinspritzung Verwendung finden.
KW  - Brennkraftmaschine
KW  - Brennstoffeinspritzsystem
Y1  - 1989
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - JOUR
A1  - Honarvarfard, Elham
A1  - Gamella, Maria
A1  - Channaveerappa, Devika
A1  - Darie, Costel C.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - Electrochemically Stimulated Insulin Release from a Modified Graphene–functionalized Carbon Fiber Electrode
JF  - Electroanalysis
N2  - A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9–10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of −1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species.
Y1  - 2017
U6  - http://dx.doi.org/10.1002/elan.201700095
SN  - 1521-4109
VL  - 29
IS  - 6
SP  - 1543
EP  - 1553
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Honarvarfard, Elham
A1  - Gamella, Maria
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer
JF  - Applied Materials Today
N2  - An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte–insulator–semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
KW  - Electrolyte–insulator–semiconductor
KW  - Capacitive field-effect
KW  - CNOT
KW  - XOR
KW  - Enzyme logic gate
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.apmt.2017.08.003
SN  - 2352-9407
VL  - 9
SP  - 266
EP  - 270
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Duong, Minh Tuan
A1  - Staat, Manfred
T1  - Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement
JF  - Journal of the mechanical behavior of biomedical materials
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.jmbbm.2017.06.012
SN  - 1751-6161
VL  - 74
SP  - 400
EP  - 410
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Staat, Manfred
T1  - Optical strain measurement for the modeling of surgical meshes and their porosity
JF  - Current Directions in Biomedical Engineering
N2  - The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.
Y1  - 2018
U6  - http://dx.doi.org/10.1515/cdbme-2018-0045
SN  - 2364-5504
VL  - Band 4
IS  - 1
SP  - 181
EP  - 184
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Staat, Manfred
A1  - Perez-Viana, Daniel
A1  - Simmen, Hans-Peter
A1  - Neuhaus, Valentin
A1  - Pape, Hans-Christoph
A1  - Prescher, Andreas
A1  - Ciritsis, Bernhard
T1  - Biomechanical in vitro examination of a standardized low-volume tubular femoroplasty
JF  - Clinical Biomechanics
N2  - Background
Osteoporosis is associated with the risk of fractures near the hip. Age and comorbidities increase the perioperative risk. Due to the ageing population, fracture of the proximal femur also proves to be a socio-economic problem. Preventive surgical measures have hardly been used so far.

Methods
10 pairs of human femora from fresh cadavers were divided into control and low-volume femoroplasty groups and subjected to a Hayes fall-loading fracture test. The results of the respective localization and classification of the fracture site, the Singh index determined by computed tomography (CT) examination and the parameters in terms of fracture force, work to fracture and stiffness were evaluated statistically and with the finite element method. In addition, a finite element parametric study with different position angles and variants of the tubular geometry of the femoroplasty was performed.

Findings
Compared to the control group, the work to fracture could be increased by 33.2%. The fracture force increased by 19.9%. The used technique and instrumentation proved to be standardized and reproducible with an average poly(methyl methacrylate) volume of 10.5 ml. The parametric study showed the best results for the selected angle and geometry.

Interpretation
The cadaver studies demonstrated the biomechanical efficacy of the low-volume tubular femoroplasty. The numerical calculations confirmed the optimal choice of positioning as well as the inner and outer diameter of the tube in this setting. The standardized minimally invasive technique with the instruments developed for it could be used in further comparative studies to confirm the measured biomechanical results.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.clinbiomech.2020.105104
VL  - 80
IS  - Art. 105104
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Horstmann, Marie-Therese
A1  - Bialonski, Stephan
A1  - Noenning, Nina
A1  - Mai, Heinke
A1  - Prusseit, Jens
A1  - Wellmer, Jörg
A1  - Hinrichs, Hermann
A1  - Lehnertz, Klaus
T1  - State dependent properties of epileptic brain networks: Comparative graph–theoretical analyses of simultaneously recorded EEG and MEG
JF  - Clinical Neurophysiology
N2  - Objective
To investigate whether functional brain networks of epilepsy patients treated with antiepileptic medication differ from networks of healthy controls even during the seizure-free interval.

Methods
We applied different rules to construct binary and weighted networks from EEG and MEG data recorded under a resting-state eyes-open and eyes-closed condition from 21 epilepsy patients and 23 healthy controls. The average shortest path length and the clustering coefficient served as global statistical network characteristics.

Results
Independent on the behavioral condition, epileptic brains exhibited a more regular functional network structure. Similarly, the eyes-closed condition was characterized by a more regular functional network structure in both groups. The amount of network reorganization due to behavioral state changes was similar in both groups. Consistent findings could be achieved for networks derived from EEG but hardly from MEG recordings, and network construction rules had a rather strong impact on our findings.

Conclusions
Despite the locality of the investigated processes epileptic brain networks differ in their global characteristics from non-epileptic brain networks. Further methodological developments are necessary to improve the characterization of disturbed and normal functional networks.

Significance
An increased regularity and a diminished modulation capability appear characteristic of epileptic brain networks.
Y1  - 2010
U6  - http://dx.doi.org/10.1016/j.clinph.2009.10.013
SN  - 1388-2457
VL  - 121
IS  - 2
SP  - 172
EP  - 185
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Huck, Christina
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Bifunktionaler Sensorchip für den Nachweis von Gelöstwasserstoff
Y1  - 2011
SN  - 978-3942710-53-4
U6  - http://dx.doi.org/10.5162/10dss2011/16.10
SP  - 325
EP  - 328
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Jolly, Christina
A1  - Wagner, Patrick
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 1161
EP  - 1164
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Buniatyan, V.
A1  - Schöning, Michael Josef
T1  - Multi-parameter detection for supporting monitoring and control of biogas processes in agriculture
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 5
PB  - VDE-Verl.
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Chaudhuri, S.
A1  - Zander, W.
A1  - Schubert, J.
A1  - Begoyan, V. K.
A1  - Buniatyan, V. V.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate
JF  - Sensors and actuators. B: Chemical
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.snb.2014.02.103
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
IS  - 198
SP  - 102
EP  - 109
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Reisert, Steffen
A1  - Kramer, Friederike
A1  - Begoyan, Vardges K.
A1  - Buniatyan, Vahe V.
A1  - Schöning, Michael Josef
T1  - Multi-parameter sensing using high-k oxide of barium strontium titanate
JF  - Physica status solidi (a)
N2  - High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors. In this work, a Si-based sensor chip containing Pt interdigitated electrodes covered with a thin BST layer (485 nm) has been developed for multi-parameter chemical sensing. The chip has been applied for the contactless measurement of the electrolyte conductivity, the detection of adsorbed charged macromolecules (positively charged polyelectrolytes of polyethylenimine) and the concentration of hydrogen peroxide (H2O2) vapor. The experimental results of functional testing of individual sensors are presented. The mechanism of the BST sensitivity to charged polyelectrolytes and H2O2 vapor has been proposed and discussed.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431911
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1259
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Reisert, Steffen
A1  - Schubert, J.
A1  - Zander, W.
A1  - Begoyan, V. K.
A1  - Buniatyan, V. V.
A1  - Schöning, Michael Josef
T1  - Chemical sensors based on a high-k perovskite oxide of barium strontium titanate
JF  - Procedia Engineering
N2  - High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors for liquids. In this work, BST films have been applied as a sensitive transducer material for a label-free detection of adsorbed charged macromolecules (positively charged polyelectrolytes) and concentration of hydrogen peroxide vapor as well as protection insulator layer for a contactless electrolyte-conductivity sensor. The experimental results of characterization of individual sensors are presented. Special emphasis is devoted towards the development of a capacitively-coupled contactless electrolyte-conductivity sensor.
KW  - barium strontium titanate
KW  - high-k material
KW  - contactless conductivity sensor
KW  - multi-functional material
KW  - hydrogen peroxide
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.proeng.2014.11.258
SN  - 1877-7058
N1  - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014>
VL  - 87
SP  - 28
EP  - 31
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Zander, W.
A1  - Schubert, J.
A1  - Sukoyan, L. H.
A1  - Begoyan, V.
A1  - Buniatyan, V. V.
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Chemische Sensoren mit Bariumstrontiumtitanat als funktionelle Schicht zur Multiparameterdetektion
T2  - 11. Dresdner Sensor-Symposium : 9.-11.12.2013
Y1  - 2013
SN  - 978-3-9813484-5-3
SP  - 368
EP  - 372
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Kerroumi, Iman
A1  - Schusser, Sebastian
A1  - Bäcker, Matthias
A1  - Zander, Willi
A1  - Schubert, Jürgen
A1  - Buniatyan, Vahe V.
A1  - Martirosyan, Norayr W.
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Multiparameter sensor chip with Barium Strontium Titanate as multipurpose material
JF  - Electroanalysis
N2  - It is well known that biochemical and biotechnological processes are strongly dependent and affected by a variety of physico-chemical parameters such as pH value, temperature, pressure and electrolyte conductivity. Therefore, these quantities have to be monitored or controlled in order to guarantee a stable process operation, optimization and high yield. In this work, a sensor chip for the multiparameter detection of three physico-chemical parameters such as electrolyte conductivity, pH and temperature is realized using barium strontium titanate (BST) as multipurpose material. The chip integrates a capacitively coupled four-electrode electrolyte-conductivity sensor, a capacitive field-effect pH sensor and a thin-film Pt-temperature sensor. Due to the multifunctional properties of BST, it is utilized as final outermost coating layer of the processed sensor chip and serves as passivation and protection layer as well as pH-sensitive transducer material at the same time. The results of testing of the individual sensors of the developed multiparameter sensor chip are presented. In addition, a quasi-simultaneous multiparameter characterization of the sensor chip in buffer solutions with different pH value and electrolyte conductivity is performed. To study the sensor behavior and the suitability of BST as multifunctional material under harsh environmental conditions, the sensor chip was exemplarily tested in a biogas digestate.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/elan.201400076
SN  - 1521-4109 (E-Journal); 1040-0397 (Print)
VL  - 26
IS  - 5
SP  - 980
EP  - 987
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Combined amperometric/field-effect sensor for the detection of dissolved hydrogen
JF  - Sensors and  actuators B: Chemical
N2  - Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3% (v/v) with a slope of 198.4 ± 13.7 nA/% (v/v) and 14.9 ± 0.5 mV/% (v/v), respectively.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2012.10.050
SN  - 0925-4005
N1  - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors"
VL  - 187
SP  - 168
EP  - 173
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Schiffels, Johannes
A1  - Herrera, Cony N.
A1  - Schelden, Maximilian
A1  - Selmer, Thorsten
A1  - Poghossian, Arshak
A1  - Baumann, Marcus
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Metabolic responses of Escherichia coli upon glucose pulses captured by a capacitive field-effect sensor
JF  - Physica Status Solidi (A)
N2  - Living cells are complex biological systems transforming metabolites taken up from the surrounding medium. Monitoring the responses of such cells to certain substrate concentrations is a challenging task and offers possibilities to gain insight into the vitality of a community influenced by the growth environment. Cell-based sensors represent a promising platform for monitoring the metabolic activity and thus, the “welfare” of relevant organisms. In the present study, metabolic responses of the model bacterium Escherichia coli in suspension, layered onto a capacitive field-effect structure, were examined to pulses of glucose in the concentration range between 0.05 and 2 mM. It was found that acidification of the surrounding medium takes place immediately after glucose addition and follows Michaelis–Menten kinetic behavior as a function of the glucose concentration. In future, the presented setup can, therefore, be used to study substrate specificities on the enzymatic level and may as well be used to perform investigations of more complex metabolic responses. Conclusions and perspectives highlighting this system are discussed.
Y1  - 2013
U6  - http://dx.doi.org/10.1002/pssa.201200900
SN  - 0031-8965
VL  - 210
IS  - 5
SP  - 926
EP  - 931
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Hugenroth, Kristin
A1  - Borchardt, Ralf
A1  - Ritter, Philine
A1  - Groß‑Hardt, Sascha
A1  - Meyns, Bart
A1  - Verbelen, Tom
A1  - Steinseifer, Ulrich
A1  - Kaufmann, Tim A. S.
A1  - Engelmann, Ulrich M.
T1  - Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input
JF  - Scientific Reports
N2  - Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.
Y1  - 2021
U6  - http://dx.doi.org/10.1038/s41598-021-96397-2
SN  - 2045-2322
VL  - 11
IS  - Art. No. 16800
SP  - 1
EP  - 12
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hugenroth, Kristin
A1  - Neidlin, Michael
A1  - Engelmann, Ulrich M.
A1  - Kaufmann, Tim A. S.
A1  - Steinseifer, Ulrich
A1  - Heilmann, Torsten
T1  - Tipless Transseptal Cannula Concept Combines Improved Hemodynamic Properties and Risk‐Reduced Placement: an In Silico Proof‐of‐Concept
JF  - Artificial Organs
Y1  - 2021
U6  - http://dx.doi.org/10.1111/aor.13964
SN  - 1525-1594
IS  - Accepted Article
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Hunker, Jan
A1  - Jung, Alexander
A1  - Goßmann, Matthias
A1  - Linder, Peter
A1  - Staat, Manfred
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
N2  - The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - http://dx.doi.org/10.17185/duepublico/48750
SP  - 7
EP  - 8
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Hunker, Jan L.
A1  - Gossmann, Matthias
A1  - Raman, Aravind Hariharan
A1  - Linder, Peter
T1  - Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility
JF  - Journal of Pharmacological and Toxicological Methods
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.vascn.2021.107044
SN  - 1056-8719
VL  - 111
IS  - Article number 107044
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Hüllenkremer, B.
A1  - Glück, O.
A1  - Emons, H.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Voltohmmetrie an polykristallinen Goldelektroden
JF  - Gesellschaft Mess- und Automatisierungstechnik: Sensoren und Meßsysteme 2000 : Tagung Ludwigsburg, 13. und 14. März 2000 / VDI/VDE-Gesellschaft Meß- und Automatisierungstechnik
Y1  - 2000
SN  - 3-18-091530-7
N1  - VDI-Berichte; 1530
SP  - 45
EP  - 54
PB  - VDI-Verl.
CY  - Düsseldorf:
ER  - 
TY  - JOUR
A1  - Iken, Heiko
A1  - Ahlborn, K.
A1  - Gerlach, F.
A1  - Vonau, W.
A1  - Zander, W.
A1  - Schubert, J.
A1  - Schöning, Michael Josef
T1  - Development of redox glasses and subsequent processing by means of pulsed laser deposition for realizing silicon-based thin-film sensors
JF  - Electrochimica acta
Y1  - 2013
SN  - 1873-3859 (E-Journal); 0013-4686 (Print)
SP  - Available online 30.8.2013
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Iken, Heiko
A1  - Bronder, Thomas
A1  - Goretzki, Alexander
A1  - Kriesel, Jana
A1  - Ahlborn, Kristina
A1  - Gerlach, Frank
A1  - Vonau, Winfried
A1  - Zander, Willi
A1  - Schubert, Jürgen
A1  - Schöning, Michael Josef
T1  - Development of a Combined pH- and Redox-Sensitive Bi-Electrode Glass Thin-Film Sensor
JF  - physica status solidi a : applications and materials sciences
Y1  - 2019
U6  - http://dx.doi.org/10.1002/pssa.201900114
SN  - 1862-6319
VL  - 216
IS  - 12
SP  - 1
EP  - 8
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Iken, Heiko
A1  - Kirsanov, D.
A1  - Legin, A.
A1  - Schöning, Michael Josef
T1  - Novel Thin-Film Polymeric Materials for the Detection of Heavy Metals
JF  - Procedia Engineering
N2  - A variety of transition metals, e.g., copper, zinc, cadmium, lead, etc. are widely used in industry as components for wires, coatings, alloys, batteries, paints and so on. The inevitable presence of transition metals in industrial processes implies the ambition of developing a proper analytical technique for their adequate monitoring. Most of these elements, especially lead and cadmium, are acutely toxic for biological organisms. Quantitative determination of these metals at low activity levels in different environmental and industrial samples is therefore a vital task. A promising approach to achieve an at-side or on-line monitoring on a miniaturized and cost efficient way is the combination of a common potentiometric sensor array with heavy metal-sensitive thin-film materials, like chalcogenide glasses and polymeric materials, respectively.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.proeng.2012.09.148
SN  - 1877-7058
N1  - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012"
IS  - 47
SP  - 322
EP  - 325
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ingebrandt, S.
A1  - Han, Y.
A1  - Nakamura, F.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Offenhäusser, A.
T1  - Label-free detection of single nucleotide polymorphisms utilizing the differential transfer function of field-effect transistors
JF  - Biosensors and Bioelectronics. 22 (2007), H. 12
Y1  - 2007
SN  - 0956-5663
SP  - 2834
EP  - 2840
ER  - 
TY  - GEN
A1  - Ingebrandt, Sven
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Engineering of functional interfaces / guest eds. Sven Ingebrandt ; Patrick Wagner ; Michael J. Schöning
T2  - Physica Status Solidi (A)
Y1  - 2013
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - Vol. 210
IS  - Iss. 5
SP  - 845
ER  - 
TY  - BOOK
A1  - Iomdina, E. N.
A1  - Bauer, S. M.
A1  - Kotliar, Konstantin
T1  - БИОМЕХАНИКА ГЛАЗА: ТЕОРЕТИЧЕСКИЕ АСПЕКТЫ И КЛИНИЧЕСКИЕ ПРИЛОЖЕНИЯ
T2  - Eye biomechanics : theoretical aspects and clinical applications
Y1  - 2015
SN  - 978-5-903025-57-2
PB  - Real Time
CY  - Moscow
ER  - 
TY  - CHAP
A1  - Iomdina, Elena N.
A1  - Kiseleva, Anna A.
A1  - Kotliar, Konstantin
A1  - Luzhnov, Petr V.
T1  - Quantification of Choroidal Blood Flow Using the OCT-A System Based on Voxel Scan Processing
T2  - 2020 International Conference on Biomedical Innovations and Applications (BIA)
Y1  - 2020
SN  - 978-1-7281-7073-2
U6  - http://dx.doi.org/10.1109/BIA50171.2020.9244511
SP  - 41
EP  - 44
ER  - 
TY  - JOUR
A1  - Ismail, A.B.M.
A1  - Harada, T.
A1  - Yoshinobu, T.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
T1  - Investigation of pulsed laser-deposited Al2O3 as a high pH-sensitive layer for LAPS-based biosensing applications
JF  - Sensors and Actuators B. 71 (2000), H. 3
Y1  - 2000
SN  - 0925-4005
SP  - 169
EP  - 172
ER  - 
TY  - JOUR
A1  - Itabashi, Akinori
A1  - Kosaka, Naoki
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - High-speed chemical imaging system based on front-side-illuminated LAPS
JF  - Sensors and actuators B: Chemical
N2  - The chemical imaging sensor is a semiconductor-based chemical sensor that can visualize the spatial distribution of specific ions on the sensing surface. The conventional chemical imaging system based on the light-addressable potentiometric sensor (LAPS), however, required a long time to obtain a chemical image, due to the slow mechanical scan of a single light beam. For high-speed imaging, a plurality of light beams modulated at different frequencies can be employed to measure the ion concentrations simultaneously at different locations on the sensor plate by frequency division multiplex (FDM). However, the conventional measurement geometry of back-side illumination limited the bandwidth of the modulation frequency required for FDM measurement, because of the low-pass filtering characteristics of carrier diffusion in the Si substrate. In this study, a high-speed chemical imaging system based on front-side-illuminated LAPS was developed, which achieved high-speed spatiotemporal recording of pH change at a rate of 70 frames per second.
Y1  - 2013
U6  - http://dx.doi.org/10.1016/j.snb.2013.03.016
SN  - 1873-3077
VL  - 182
SP  - 315
EP  - 321
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Jabbari, Medisa
A1  - Bhattarai, Aroj
A1  - Anding, Ralf
A1  - Staat, Manfred
ED  - Erni, Daniel
ED  - Fischerauer, Alice
ED  - Himmel, Jörg
ED  - Seeger, Thomas
ED  - Thelen, Klaus
T1  - Biomechanical simulation of different prosthetic meshes for repairing uterine/vaginal vault prolapse
T2  - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West
Y1  - 2017
SN  - 978-3-9814801-9-1
U6  - http://dx.doi.org/10.17185/duepublico/43984
N1  - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017
SP  - 118
EP  - 119
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - CHAP
A1  - Jablonski, Melanie
A1  - Koch, Claudia
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier
T2  - MDPI Proceeding
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1040505
N1  - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
VL  - 1
IS  - 4
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Münstermann, Felix
A1  - Nork, Jasmina
A1  - Molinnus, Denise
A1  - Muschallik, Lukas
A1  - Bongaerts, Johannes
A1  - Wagner, Torsten
A1  - Keusgen, Michael
A1  - Siegert, Petra
A1  - Schöning, Michael Josef
T1  - Capacitive field‐effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths
JF  - physica status solidi (a) applications and materials science
N2  - An acetoin biosensor based on a capacitive electrolyte–insulator–semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance–voltage, and constant capacitance methods, respectively.
KW  - acetoin
KW  - acetoin reductase
KW  - alcoholic beverages
KW  - biosensors
KW  - capacitive field-effect sensors
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000765
SN  - 1862-6319
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Detection of plant virus particles with a capacitive field-effect sensor
JF  - Analytical and Bioanalytical Chemistry
N2  - Plant viruses are major contributors to crop losses and induce high economic costs worldwide. For reliable, on-site and early detection of plant viral diseases, portable biosensors are of great interest. In this study, a field-effect SiO2-gate electrolyte-insulator-semiconductor (EIS) sensor was utilized for the label-free electrostatic detection of tobacco mosaic virus (TMV) particles as a model plant pathogen. The capacitive EIS sensor has been characterized regarding its TMV sensitivity by means of constant-capacitance method. The EIS sensor was able to detect biotinylated TMV particles from a solution with a TMV concentration as low as 0.025 nM. A good correlation between the registered EIS sensor signal and the density of adsorbed TMV particles assessed from scanning electron microscopy images of the SiO2-gate chip surface was observed. Additionally, the isoelectric point of the biotinylated TMV particles was determined via zeta potential measurements and the influence of ionic strength of the measurement solution on the TMV-modified EIS sensor signal has been studied.
KW  - Plant virus
KW  - Capacitive field-effect sensor
KW  - Tobacco mosaic virus (TMV)
KW  - Label-free detection
KW  - Zeta potential
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s00216-021-03448-8
SN  - 1618-2650
N1  - Corresponding authors: Arshak Poghossian & Michael J. Schöning
VL  - 413
SP  - 5669
EP  - 5678
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Poghossian, Arshak
A1  - Severin, Robin
A1  - Keusgen, Michael
A1  - Wege, Christian
A1  - Schöning, Michael Josef
T1  - Capacitive Field-Effect Biosensor Studying Adsorption of Tobacco Mosaic Virus Particles
JF  - Micromachines
N2  - Plant virus-like particles, and in particular, tobacco mosaic virus (TMV) particles, are increasingly being used in nano- and biotechnology as well as for biochemical sensing purposes as nanoscaffolds for the high-density immobilization of receptor molecules. The sensitive parameters of TMV-assisted biosensors depend, among others, on the density of adsorbed TMV particles on the sensor surface, which is affected by both the adsorption conditions and surface properties of the sensor. In this work, Ta₂O₅-gate field-effect capacitive sensors have been applied for the label-free electrical detection of TMV adsorption. The impact of the TMV concentration on both the sensor signal and the density of TMV particles adsorbed onto the Ta₂O₅-gate surface has been studied systematically by means of field-effect and scanning electron microscopy methods. In addition, the surface density of TMV particles loaded under different incubation times has been investigated. Finally, the field-effect sensor also demonstrates the label-free detection of penicillinase immobilization as model bioreceptor on TMV particles.
KW  - capacitive field-effect sensor
KW  - plant virus detection
KW  - tobacco mosaic virus (TMV)
KW  - TMV adsorption
KW  - Ta₂O₅ gate
Y1  - 2021
U6  - http://dx.doi.org/10.3390/mi12010057
VL  - 12
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Jahnke, Siegfried
A1  - Menzel, Marion I.
A1  - Dusschoten, Dagmar van
A1  - Roeb, Gerhard W.
A1  - Bühler, Jonas
A1  - Minwuyelet, Senay
A1  - Blümler, Peter
A1  - Temperton, Vicky M.
A1  - Hombach, Thomas
A1  - Streun, Matthias
A1  - Beer, Simone
A1  - Khodaverdi, Maryam
A1  - Ziemons, Karl
A1  - Coenen, Heinz H.
A1  - Schurr, Ulrich
T1  - Combined MRI–PET dissects dynamic changes in plant structures and functions
JF  - The Plant Journal
N2  - Unravelling the factors determining the allocation of carbon to various plant organs is one of the great challenges of modern plant biology. Studying allocation under close to natural conditions requires non-invasive methods, which are now becoming available for measuring plants on a par with those developed for humans. By combining magnetic resonance imaging (MRI) and positron emission tomography (PET), we investigated three contrasting root/shoot systems growing in sand or soil, with respect to their structures, transport routes and the translocation dynamics of recently fixed photoassimilates labelled with the short-lived radioactive carbon isotope 11C. Storage organs of sugar beet (Beta vulgaris) and radish plants (Raphanus sativus) were assessed using MRI, providing images of the internal structures of the organs with high spatial resolution, and while species-specific transport sectoralities, properties of assimilate allocation and unloading characteristics were measured using PET. Growth and carbon allocation within complex root systems were monitored in maize plants (Zea mays), and the results may be used to identify factors affecting root growth in natural substrates or in competition with roots of other plants. MRI–PET co-registration opens the door for non-invasive analysis of plant structures and transport processes that may change in response to genomic, developmental or environmental challenges. It is our aim to make the methods applicable for quantitative analyses of plant traits in phenotyping as well as in understanding the dynamics of key processes that are essential to plant performance.
Y1  - 2009
SN  - 1365-313X
VL  - 59
IS  - 4
SP  - 634
EP  - 644
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jahnke, Siegfried
A1  - Roussel, Johanna
A1  - Hombach, Thomas
A1  - Kochs, Johannes
A1  - Fischbach, Andreas
A1  - Huber, Gregor
A1  - Scharr, Hanno
T1  - phenoSeeder - A robot system for automated handling and phenotyping of individual seeds
JF  - Plant physiology
N2  - The enormous diversity of seed traits is an intriguing feature and critical for the overwhelming success of higher plants. In particular, seed mass is generally regarded to be key for seedling development but is mostly approximated by using scanning methods delivering only two-dimensional data, often termed seed size. However, three-dimensional traits, such as the volume or mass of single seeds, are very rarely determined in routine measurements. Here, we introduce a device named phenoSeeder, which enables the handling and phenotyping of individual seeds of very different sizes. The system consists of a pick-and-place robot and a modular setup of sensors that can be versatilely extended. Basic biometric traits detected for individual seeds are two-dimensional data from projections, three-dimensional data from volumetric measures, and mass, from which seed density is also calculated. Each seed is tracked by an identifier and, after phenotyping, can be planted, sorted, or individually stored for further evaluation or processing (e.g. in routine seed-to-plant tracking pipelines). By investigating seeds of Arabidopsis (Arabidopsis thaliana), rapeseed (Brassica napus), and barley (Hordeum vulgare), we observed that, even for apparently round-shaped seeds of rapeseed, correlations between the projected area and the mass of seeds were much weaker than between volume and mass. This indicates that simple projections may not deliver good proxies for seed mass. Although throughput is limited, we expect that automated seed phenotyping on a single-seed basis can contribute valuable information for applications in a wide range of wild or crop species, including seed classification, seed sorting, and assessment of seed quality.
Y1  - 2016
U6  - http://dx.doi.org/10.1104/pp.16.01122
SN  - 0032-0889
VL  - 172
IS  - 3
SP  - 1358
EP  - 1370
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Jansen, S. V.
A1  - Behbahani, Mehdi
A1  - Laumen, M.
A1  - Kaufmann, T.
A1  - Hormes, M.
A1  - Behr, M.
A1  - Schmitz-Rode, T.
A1  - Steinseifer, U.
T1  - Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation
Y1  - 2010
N1  - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Jansen, Sebastian
A1  - Behbahani, Mehdi
A1  - Laumen, Marco
A1  - Kaufmann, Tim
A1  - Hormes, Marcus
A1  - Schmitz-Rode, Thomas
A1  - Behr, Marek
A1  - Steinseifer, Ulrich
T1  - 3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques
Y1  - 2010
N1  - abstract ; IV International Symposium on Modelling of Physiological Flows, Sardinia, Italy, June 02-05, 2010 ; MPF2010
ER  - 
TY  - JOUR
A1  - Janus, Kevin Alexander
A1  - Achtsnicht, Stefan
A1  - Drinic, Aleksander
A1  - Kopp, Alexander
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Transient magnesium-based thin-film temperature sensor on a flexible, bioabsorbable substrate for future medical applications
JF  - Applied Research
N2  - In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin-film magnesium-based meander-like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium-based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue-like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium-based layers. The 3-layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C.
KW  - Silk fibroin
KW  - Polylactide  acid
KW  - Bioabsorbable
KW  - Resistive  temperature detector
Y1  - 2023
U6  - http://dx.doi.org/10.1002/appl.202300102
SN  - 2702-4288 (Print)
N1  - Corresponding author: Michael Josef Schöning
IS  - Accepted manuscript
PB  - Wiley-VCH
ER  - 
TY  - JOUR
A1  - Janus, Kevin Alexander
A1  - Achtsnicht, Stefan
A1  - Tempel, Laura
A1  - Drinic, Aleksaner
A1  - Kopp, Alexander
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon
JF  - Physica status solidi : pss. A, Applications and materials science
N2  - Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5–10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.
KW  - amperometric biosensors
KW  - biocompatible
KW  - biodegradabl
KW  - encapsulation materials
KW  - fibroin
Y1  - 2023
U6  - http://dx.doi.org/10.1002/pssa.202300081
SN  - 1862-6300 (Print)
SN  - 1862-6319 (Online)
N1  - Corresponding author: Michael J. Schöning
VL  - 220
IS  - 22
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jayaraman, Chandrasekaran
A1  - Mummidisetty, Chaitanya Krishna
A1  - Loesch, Alexandra
A1  - Kaur, Sandi
A1  - Hoppe-Ludwig, Shenan
A1  - Staat, Manfred
A1  - Jayaraman, Arun
T1  - Postural and metabolic benefits of using a forearm support walker in older adults with impairments
JF  - Archives of Physical Medicine and Rehabilitation
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.apmr.2018.10.001
SN  - 0003-9993
VL  - Volume 100
IS  - Issue 4
SP  - 638
EP  - 647
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Kirchner, Patrick
A1  - Baltes, Klaus
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Development of an in-line evaporation unit for the production of gas mixtures containing hydrogen peroxide – numerical modeling and experimental results
JF  - International Journal of Heat and Mass Transfer
N2  - Hydrogen peroxide (H2O2) is a typical surface sterilization agent for packaging materials used in the pharmaceutical, food and beverage industries. We use the finite-elements method to analyze the conceptual design of an in-line thermal evaporation unit to produce a heated gas mixture of air and evaporated H2O2 solution. For the numerical model, the required phase-transition variables of pure H2O2  solution and of the aerosol mixture are acquired from vapor-liquid equilibrium (VLE) diagrams derived from vapor-pressure formulations. This work combines homogeneous single-phase turbulent flow with heat-transfer physics to describe the operation of the evaporation unit. We introduce the apparent heat-capacity concept to approximate the non-isothermal phase-transition process of the H2O2-containing aerosol. Empirical and analytical functions are defined to represent the temperature- and pressure-dependent material properties of the aqueous H2O2 solution, the aerosol and the gas mixture. To validate the numerical model, the simulation results are compared to experimental data on the heating power required to produce the gas mixture. This shows good agreement with the deviations below 10%. Experimental observations on the formation of deposits due to the evaporation of stabilized H2O2 solution fits the prediction made from simulation results.
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.ijheatmasstransfer.2019.118519
SN  - 0017-9310
VL  - 143
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Kirchner, Patrick
A1  - Oberländer, Jan
A1  - Kremers, Alexander
A1  - Wagner, Torsten
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - FEM-based modeling of a calorimetric gas sensor for hydrogen peroxide monitoring
JF  - physica status solidi a : applications and materials sciences
N2  - A physically coupled finite element method (FEM) model is developed to study the response behavior of a calorimetric gas sensor. The modeled sensor serves as a monitoring device of the concentration of gaseous hydrogen peroxide (H2 O2) in a high temperature mixture stream in aseptic sterilization processes. The principle of operation of a calorimetric H2 O2 sensor is analyzed and the results of the numerical model have been validated by using previously published sensor experiments. The deviation in the results between the FEM model and experimental data are presented and discussed.
Y1  - 2017
U6  - http://dx.doi.org/10.1002/pssa.201600912
SN  - 1862-6319
IS  - Early View
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Kirchner, Patrick
A1  - Oberländer, Jan
A1  - Vahidpour, Farnoosh
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Development of a package-sterilization process for aseptic filling machines: A numerical approach and validation for surface treatment with hydrogen peroxide
JF  - Sensor and Actuators A: Physical
N2  - Within the present work a sterilization process by a heated gas mixture that contains hydrogen peroxide (H₂O₂) is validated by experiments and numerical modeling techniques. The operational parameters that affect the sterilization efficacy are described alongside the two modes of sterilization: gaseous and condensed H₂O₂. Measurements with a previously developed H₂O₂ gas sensor are carried out to validate the applied H₂O₂ gas concentration during sterilization. We performed microbiological tests at different H₂O₂ gas concentrations by applying an end-point method to carrier strips, which contain different inoculation loads of Geobacillus stearothermophilus spores. The analysis of the sterilization process of a pharmaceutical glass vial is performed by numerical modeling. The numerical model combines heat- and advection-diffusion mass transfer with vapor–pressure equations to predict the location of condensate formation and the concentration of H₂O₂ at the packaging surfaces by changing the gas temperature. For a sterilization process of 0.7 s, a H₂O₂ gas concentration above 4% v/v is required to reach a log-count reduction above six. The numerical results showed the location of H₂O₂ condensate formation, which decreases with increasing sterilant-gas temperature. The model can be transferred to different gas nozzle- and packaging geometries to assure the absence of H₂O₂ residues.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.sna.2019.111691
SN  - 0924-4247
VL  - 303
IS  - 111691
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Oberländer, Jan
A1  - Kirchner, Patrick
A1  - Keusgen, Michael
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Experimental and Numerical Analyzes of a Sensor Based on Interdigitated Electrodes for Studying Microbiological Alterations
JF  - physica status solidi (a): applications and materials science
N2  - In this work, a cell-based biosensor to evaluate the sterilization efficacy of hydrogen peroxide vapor sterilization processes is characterized. The transducer of the biosensor is based on interdigitated gold electrodes fabricated on an inert glass substrate. Impedance spectroscopy is applied to evaluate the sensor behavior and the alteration of test microorganisms due to the sterilization process. These alterations are related to changes in relative permittivity and electrical conductivity of the bacterial spores. Sensor measurements are conducted with and without bacterial spores (Bacillus atrophaeus), as well as after an industrial sterilization protocol. Equivalent two-dimensional numerical models based on finite element method of the periodic finger structures of the interdigitated gold electrodes are designed and validated using COMSOL® Multiphysics software by the application of known dielectric properties. The validated models are used to compute the electrical properties at different sensor states (blank, loaded with spores, and after sterilization). As a final result, we will derive and tabulate the frequency-dependent electrical parameters of the spore layer using a novel model that combines experimental data with numerical optimization techniques.
Y1  - 2018
U6  - http://dx.doi.org/10.1002/pssa.201700920
SN  - 1862-6319
VL  - 215
IS  - 15
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Oberländer, Jan
A1  - Kirchner, Patrick
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Thermocatalytic Behavior of Manganese (IV) Oxide as Nanoporous Material on the Dissociation of a Gas Mixture Containing Hydrogen Peroxide
JF  - Nanomaterials
N2  - In this article, we present an overview on the thermocatalytic reaction of hydrogen peroxide (H₂O₂) gas on a manganese (IV) oxide (MnO₂) catalytic structure. The principle of operation and manufacturing techniques are introduced for a calorimetric H₂O₂ gas sensor based on porous MnO₂. Results from surface analyses by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) of the catalytic material provide indication of the H₂O₂ dissociation reaction schemes. The correlation between theory and the experiments is documented in numerical models of the catalytic reaction. The aim of the numerical models is to provide further information on the reaction kinetics and performance enhancement of the porous MnO₂ catalyst.
Y1  - 2018
U6  - http://dx.doi.org/10.3390/nano8040262
SN  - 2079-4991
VL  - 8
IS  - 4
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020
JF  - physica status solidi (a) applications and materials science
N2  - The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.
KW  - bioburdens
KW  - sterility tests
KW  - sterilization efficacy
KW  - sterilization methods
KW  - validation methods
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000732
SN  - 1862-6319
N1  - Corresponding author: Michael J. Schöning
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Pieper, Martin
T1  - Simulating the electromagnetic‐thermal treatment of thin aluminium layers for adhesion improvement
JF  - Physica status solidi (a)
N2  - A composite layer material used in packaging industry is made from joining layers of different materials using an adhesive. An important processing step in the production of aluminium-containing composites is the surface treatment and consequent coating of adhesive material on the aluminium surface. To increase adhesion strength between aluminium layer and the adhesive material, the foil is heat treated. For efficient heating, induction heating was considered as state-of-the-art treatment process. Due to the complexity of the heating process and the unpredictable nature of the heating source, the control of the process is not yet optimised. In this work, a finite element analysis of the process was established and various process parameters were studied. The process was simplified and modelled in 3D. The numerical model contains an air domain, an aluminium layer and a copper coil fitted with a magnetic field concentrating material. The effect of changing the speed of the aluminium foil (or rolling speed) was studied with the change of the coil current. Statistical analysis was used for generating a general control equation of coil current with changing rolling speed.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431893
SN  - 1862-6319
VL  - Vol. 212
IS  - 6
SP  - 1234
EP  - 1241
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jiminez German, Salvador
A1  - Behbahani, Mehdi
A1  - Miettinen, Susanna
A1  - Grijpma, Dirk W.
A1  - Haimi, Suvi P.
T1  - Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes
JF  - Macromolecular symposia
Y1  - 2013
SN  - 0258-0322
VL  - Vol. 334
IS  - Iss. 1
SP  - 133
EP  - 142
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - THES
A1  - Jung, Alexander
T1  - Electromechanical modelling and simulation of hiPSC-derived cardiac cell cultures
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?https://nbn-resolving.org/urn:nbn:de:hbz:464-20210624-134942-7
SN  - 978-3-9821811-1-0
N1  - Dissertation, Universität Duisburg-Essen, 2021
PB  - Universität Duisburg-Essen
ER  - 
TY  - CHAP
A1  - Jung, Alexander
A1  - Frotscher, Ralf
A1  - Staat, Manfred
T1  - Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts
T2  - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK
N2  - The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Wind and fairness in ski jumping: A computer modelling analysis
JF  - Journal of Biomechanics
N2  - Wind is closely associated with the discussion of fairness in ski jumping. To counter-act its influence on the jump length, the International Ski Federation (FIS) has introduced a wind compensation approach. We applied three differently accurate computer models of the flight phase with wind (M1, M2, and M3) to study the jump length effects of various wind scenarios. The previously used model M1 is accurate for wind blowing in direction of the flight path, but inaccuracies are to be expected for wind directions deviating from the tangent to the flight path. M2 considers the change of airflow direction, but it does not consider the associated change in the angle of attack of the skis which additionally modifies drag and lift area time functions. M3 predicts the length effect for all wind directions within the plane of the flight trajectory without any mathematical simplification. Prediction errors of M3 are determined only by the quality of the input data: wind velocity, drag and lift area functions, take-off velocity, and weight. For comparing the three models, drag and lift area functions of an optimized reference jump were used. Results obtained with M2, which is much easier to handle than M3, did not deviate noticeably when compared to predictions of the reference model M3. Therefore, we suggest to use M2 in future applications. A comparison of M2 predictions with the FIS wind compensation system showed substantial discrepancies, for instance: in the first flight phase, tailwind can increase jump length, and headwind can decrease it; this is opposite of what had been anticipated before and is not considered in the current wind compensation system in ski jumping.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.jbiomech.2018.05.001
SN  - 0021-9290
IS  - 75
SP  - 147
EP  - 153
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Optimization of the flight technique in ski jumping: the influence of wind
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jbiomech.2019.03.023
IS  - Early view
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - GEN
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Corrigendum to “Wind and fairness in ski jumping: A computer modelling analysis” [J. Biomech. 75 (2018) 147–153]
T2  - Journal of Biomechanics
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.jbiomech.2021.110690
SN  - 0021-9290
N1  - Refers to: Alexander Jung, Wolfram Müller, Manfred Staat: Wind and fairness in ski jumping: A computer modelling analysis. Journal of Biomechanics, Volume 75. 25 June 2018. Pages 147-153. https://doi.org/10.1016/j.jbiomech.2018.05.001
VL  - 128
IS  - Article number: 110690
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Jung, Alexander
A1  - Staat, Manfred
ED  - Erni, Daniel
T1  - Computing olympic gold: Ski jumping as an example
T2  - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen
Y1  - 2016
SN  - 978-3-940402-06-6
U6  - http://dx.doi.org/10.17185/duepublico/40821
SP  - 54
EP  - 55
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
T1  - Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue
JF  - GAMM - Mitteilungen der Gesellschaft für Angewandte Mathematik und Mechanik
Y1  - 2019
U6  - http://dx.doi.org/10.1002/gamm.201900002
SN  - 1522-2608
VL  - 42
IS  - 4
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
T1  - Erratum to "Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue" [GAMM-Mitteilungen, (2019), 42, 4, 10.1002/gamm.201900002]
JF  - GAMM-Mitteilungen
Y1  - 2020
U6  - http://dx.doi.org/10.1002/gamm.202000011
SN  - 1522-2608
N1  - Refers to: Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue. Alexander Jung, Manfred Staat.
Volume 42, Issue 4. GAMM-Mitteilungen, 2019. https://doi.org/10.1002/gamm.201900002
VL  - 43
IS  - 4
PB  - Wiley-VCH GmbH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
A1  - Müller, Wolfram
T1  - Flight style optimization in ski jumping on normal, large, and ski flying hills
JF  - Journal of biomechanics
Y1  - 2013
SN  - 1873-2380 (E-Journal); 0021-9290 (Print)
N1  - Corrigendum to “Flight style optimization in ski jumping on normal, large, and ski flying hills” [J. Biomech 47 (2014) 716-722] Journal of Biomechanics, 2018;71:313.
VL  - Vol. 47
IS  - Iss. 3
SP  - 716
EP  - 722
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Jung, Alexander
A1  - Staat, Manfred
A1  - Müller, Wolfram
ED  - Onate, E.
T1  - Optimization of the flight style in ski jumping
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona
Y1  - 2014
N1  - Das Paper wurde nach der Konferenz überarbeitet.
SP  - 799
EP  - 810
ER  - 
TY  - CHAP
A1  - Jung, Alexander
A1  - Staat, Manfred
A1  - Müller, Wolfram
T1  - Effect of wind on flight style optimisation in ski jumping
T2  - 15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK
Y1  - 2016
SP  - 53
EP  - 54
PB  - The University of Edinburgh ; Loughborough University
CY  - Edinburgh
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
A1  - Müller, Wolfram
T1  - Corrigendum to “Flight style optimization in ski jumping on normal, large, and ski flying hills” [J. Biomech 47 (2014) 716–722]
JF  - Journals of Biomechanics
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.jbiomech.2018.02.001
SN  - 0021-9290
N1  - refers to 
 Journal of Biomechanics Vol 47, Issue 3, Pages 716-722:
https://doi.org/10.1016/j.jbiomech.2013.11.021
SP  - 313
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Kahmann, Stephanie
A1  - Hackl, Michael
A1  - Wegmann, Kilian
A1  - Müller, Lars-Peter
A1  - Staat, Manfred
ED  - Erni, Daniel
T1  - Impact of a proximal radial shortening osteotomy on the distribution of forces and the stability of the elbow
T2  - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen
N2  - The human arm consists of the humerus (upper arm), the medial ulna and the lateral radius (forearm). The joint between the humerus and the ulna is called humeroulnar joint and the joint between the humerus and the radius is called humeroradial joint. Lateral and medial collateral ligaments stabilize the elbow. Statistically, 2.5 out of 10,000 people suffer from radial head fractures [1]. In these fractures the cartilage is often affected. Caused by the injured cartilage, degenerative diseases like posttraumatic arthrosis may occur. The resulting pain and reduced range of motion have an impact on the patient’s quality of life. Until now, there has not been a treatment which allows typical loads in daily life activities and offers good long-term results. A new surgical approach was developed with the motivation to reduce the progress of the posttraumatic arthrosis. Here, the radius is shortened by 3 mm in the proximal part [2]. By this means, the load of the radius is intended to be reduced due to a load shift to the ulna. Since the radius is the most important stabilizer of the elbow it has to be confirmed that the stability is not affected. In the first test (Fig. 1 left), pressure distributions within the humeroulnar and humeroradial joints a native and a shortened radius were measured using resistive pressure sensors (I5076 and I5027, Tekscan, USA). The humerus was loaded axially in a tension testing machine (Z010, Zwick Roell, Germany) in 50 N steps up to 400 N. From the humerus the load is transmitted through both the radius and the ulna into the hand which is fixed on the ground. In the second test (Fig. 1 right), the joint stability was investigated using a digital image correlation system to measure the displacement of the ulna. Here, the humerus is fixed with a desired flexion angle and the unconstrained forearm lies on the ground. A rope connects the load actuator with a hook fixed in the ulna. A guide roller is used so that the rope pulls the ulna horizontally when a tensile load is applied. This creates a moment about the elbow joint with a maximum value of 7.5 Nm. Measurements were performed with varying flexion angles (0°, 30°, 60°, 90°, 120°). For both tests and each measurement, seven specimens were used. Student ́s t-test was employed to determine whether the mean values of the measurements in native specimen and operated specimens differ significantly.
Y1  - 2016
U6  - http://dx.doi.org/10.17185/duepublico/40821
SP  - 7
EP  - 8
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - CHAP
A1  - Kahmann, Stephanie Lucina
A1  - Uschok, Stephan
A1  - Wegmann, Kilian
A1  - Müller, Lars-P.
A1  - Staat, Manfred
T1  - Biomechanical multibody model with refined kinematics of the elbow
T2  - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK
N2  - The overall objective of this study is to develop a new external fixator, which closely maps the native kinematics of the elbow to decrease the joint force resulting in reduced rehabilitation time and pain. An experimental setup was designed to determine the native kinematics of the elbow during flexion of cadaveric arms. As a preliminary study, data from literature was used to modify a published biomechanical model for the calculation of the joint and muscle forces. They were compared to the original model and the effect of the kinematic refinement was evaluated. Furthermore, the obtained muscle forces were determined in order to apply them in the experimental setup. The joint forces in the modified model differed slightly from the forces in the original model. The muscle force curves changed particularly for small flexion angles but their magnitude for larger angles was consistent.
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Kaminsky, Radoslav
A1  - Dumont, K.
A1  - Weber, Hans-Joachim
A1  - Schroll, M.
A1  - Verdonck, P.
T1  - PIV validation of blood-heart valve leaflet interaction modelling
JF  - The International journal of artificial organs. 30 (2007), H. 7
Y1  - 2007
SP  - 640
EP  - 648
PB  - -
ER  - 
TY  - JOUR
A1  - Kaminsky, Radoslav
A1  - Kallweit, Stephan
A1  - Weber, Hans-Joachim
A1  - Claessens, Tom
A1  - Jozwik, Krzystof
A1  - Verdonck, Pascal
T1  - Flow visualization through two types of aortic prosthetic heart valves using stereoscopic high-speed particle image velocimetry
JF  - Artificial organs. 31 (2007), H. 12
Y1  - 2007
SN  - 1525-1594
SP  - 869
EP  - 879
ER  - 
TY  - JOUR
A1  - Kaminsky, Radoslav
A1  - Kallweit, Stephan
A1  - Weber, Hans-Joachim
A1  - Simons, Antoine
A1  - Kramm, K.
A1  - Jazwik, K.
A1  - Moll, J.
A1  - Verdonck, P.
T1  - 3D high speed piv assessment of a new aortic heart valve prototype
JF  - Journal of biomechanics. 39 (2006), H. Supplement 1
Y1  - 2006
SN  - 0021-9290
N1  - World Congress of Biomechanics <5, 2006, München>: Abstracts of the 5th World Congress of Biomechanics
SP  - S304
EP  - S305
PB  - -
ER  - 
TY  - BOOK
A1  - Kaminsky, Radoslav
A1  - Kallweit, Stephan
A1  - Weber, Hans-Joachim
A1  - Simons, Antoine
A1  - Verdonck, Pascal
T1  - Stereo high speed PIV measurements behind two different artificial heart valves
Y1  - 2006
N1  - International Symposium on Applications of Laser Techniques to Fluid Mechanics <13, 2006, Lisboa>
ER  - 
TY  - JOUR
A1  - Kaminsky, Randolph
A1  - Simons, Antoine
A1  - Gatzweiler, Karl-Heinz
A1  - Weber, Hans-Joachim
T1  - Flow visualization by means of PIV of an artificial aortic heart valve fixed into a mock aorta
JF  - Acta Mechanica Slovaka 2-A. 9 (2005)
Y1  - 2005
SP  - 343
EP  - 348
ER  - 
TY  - JOUR
A1  - Kaminsky, Randolph
A1  - Weber, Hans-Joachim
A1  - Simons, Antoine
A1  - Kallweit, Stephan
A1  - Kramm, K.
A1  - Verdonck, Pascale
T1  - Comparison of the flow downstream two prototypes of a new monoleaflet artificial aortic heart valve by means of PIV visualization
JF  - Computer methods in biomechanics and biomedical engineering. 8 (2005), H. 4, Suppl. 1
Y1  - 2005
SN  - 1476-8259
SP  - 159
EP  - 160
ER  - 
TY  - JOUR
A1  - Kappmeyer, K.
A1  - Kotliar, Konstantin
A1  - Lanzl, I. M.
T1  - Spielen von Blasinstrumenten und Augeninnendruck
JF  - Zeitschrift für praktische Augenheilkunde & augenärztliche Fortbildung : ZPA
Y1  - 2009
SN  - 1436-0322
VL  - Bd. 30
SP  - 169
EP  - 171
ER  - 
TY  - JOUR
A1  - Karamanidis, Kiros
A1  - Albracht, Kirsten
A1  - Braunstein, Bjoern
A1  - Catala, Maria Moreno
A1  - Goldmann, Jan-Peter
A1  - Brüggemann, Gert-Peter
T1  - Lower leg musculoskeletal geometry and sprint performance
JF  - Gait and Posture
N2  - The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components.
Y1  - 2011
U6  - http://dx.doi.org/10.1016/j.gaitpost.2011.03.009
SN  - 0966-6362
VL  - 34
IS  - 1
SP  - 138
EP  - 141
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Karnatak, Rajat
A1  - Kantz, Holger
A1  - Bialonski, Stephan
T1  - Early warning signal for interior crises in excitable systems
JF  - Physical Review E
Y1  - 2017
U6  - http://dx.doi.org/10.1103/PhysRevE.96.042211
SN  - 2470-0053
VL  - 96
IS  - 4
SP  - 042211
ER  -