TY - CHAP A1 - Kahmann, Stephanie Lucina A1 - Uschok, Stephan A1 - Wegmann, Kilian A1 - Müller, Lars-P. A1 - Staat, Manfred T1 - Biomechanical multibody model with refined kinematics of the elbow T2 - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK N2 - The overall objective of this study is to develop a new external fixator, which closely maps the native kinematics of the elbow to decrease the joint force resulting in reduced rehabilitation time and pain. An experimental setup was designed to determine the native kinematics of the elbow during flexion of cadaveric arms. As a preliminary study, data from literature was used to modify a published biomechanical model for the calculation of the joint and muscle forces. They were compared to the original model and the effect of the kinematic refinement was evaluated. Furthermore, the obtained muscle forces were determined in order to apply them in the experimental setup. The joint forces in the modified model differed slightly from the forces in the original model. The muscle force curves changed particularly for small flexion angles but their magnitude for larger angles was consistent. Y1 - 2018 ER - TY - JOUR A1 - Kaminsky, Radoslav A1 - Dumont, K. A1 - Weber, Hans-Joachim A1 - Schroll, M. A1 - Verdonck, P. T1 - PIV validation of blood-heart valve leaflet interaction modelling JF - The International journal of artificial organs. 30 (2007), H. 7 Y1 - 2007 SP - 640 EP - 648 PB - - ER - TY - JOUR A1 - Kaminsky, Radoslav A1 - Kallweit, Stephan A1 - Weber, Hans-Joachim A1 - Claessens, Tom A1 - Jozwik, Krzystof A1 - Verdonck, Pascal T1 - Flow visualization through two types of aortic prosthetic heart valves using stereoscopic high-speed particle image velocimetry JF - Artificial organs. 31 (2007), H. 12 Y1 - 2007 SN - 1525-1594 SP - 869 EP - 879 ER - TY - JOUR A1 - Kaminsky, Radoslav A1 - Kallweit, Stephan A1 - Weber, Hans-Joachim A1 - Simons, Antoine A1 - Kramm, K. A1 - Jazwik, K. A1 - Moll, J. A1 - Verdonck, P. T1 - 3D high speed piv assessment of a new aortic heart valve prototype JF - Journal of biomechanics. 39 (2006), H. Supplement 1 Y1 - 2006 SN - 0021-9290 N1 - World Congress of Biomechanics <5, 2006, München>: Abstracts of the 5th World Congress of Biomechanics SP - S304 EP - S305 PB - - ER - TY - BOOK A1 - Kaminsky, Radoslav A1 - Kallweit, Stephan A1 - Weber, Hans-Joachim A1 - Simons, Antoine A1 - Verdonck, Pascal T1 - Stereo high speed PIV measurements behind two different artificial heart valves Y1 - 2006 N1 - International Symposium on Applications of Laser Techniques to Fluid Mechanics <13, 2006, Lisboa> ER - TY - JOUR A1 - Kaminsky, Randolph A1 - Simons, Antoine A1 - Gatzweiler, Karl-Heinz A1 - Weber, Hans-Joachim T1 - Flow visualization by means of PIV of an artificial aortic heart valve fixed into a mock aorta JF - Acta Mechanica Slovaka 2-A. 9 (2005) Y1 - 2005 SP - 343 EP - 348 ER - TY - JOUR A1 - Kaminsky, Randolph A1 - Weber, Hans-Joachim A1 - Simons, Antoine A1 - Kallweit, Stephan A1 - Kramm, K. A1 - Verdonck, Pascale T1 - Comparison of the flow downstream two prototypes of a new monoleaflet artificial aortic heart valve by means of PIV visualization JF - Computer methods in biomechanics and biomedical engineering. 8 (2005), H. 4, Suppl. 1 Y1 - 2005 SN - 1476-8259 SP - 159 EP - 160 ER - TY - JOUR A1 - Kappmeyer, K. A1 - Kotliar, Konstantin A1 - Lanzl, I. M. T1 - Spielen von Blasinstrumenten und Augeninnendruck JF - Zeitschrift für praktische Augenheilkunde & augenärztliche Fortbildung : ZPA Y1 - 2009 SN - 1436-0322 VL - Bd. 30 SP - 169 EP - 171 ER - TY - JOUR A1 - Karamanidis, Kiros A1 - Albracht, Kirsten A1 - Braunstein, Bjoern A1 - Catala, Maria Moreno A1 - Goldmann, Jan-Peter A1 - Brüggemann, Gert-Peter T1 - Lower leg musculoskeletal geometry and sprint performance JF - Gait and Posture N2 - The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components. Y1 - 2011 U6 - http://dx.doi.org/10.1016/j.gaitpost.2011.03.009 SN - 0966-6362 VL - 34 IS - 1 SP - 138 EP - 141 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Karnatak, Rajat A1 - Kantz, Holger A1 - Bialonski, Stephan T1 - Early warning signal for interior crises in excitable systems JF - Physical Review E Y1 - 2017 U6 - http://dx.doi.org/10.1103/PhysRevE.96.042211 SN - 2470-0053 VL - 96 IS - 4 SP - 042211 ER - TY - JOUR A1 - Karschuck, T. L. A1 - Filipov, Y. A1 - Bollella, P. A1 - Schöning, Michael Josef A1 - Katz, E. T1 - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction JF - International Journal of Unconventional Computing N2 - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions. Y1 - 2019 SN - 1548-7199 VL - 14 IS - 3-4 SP - 235 EP - 242 PB - Old City Publishing CY - Philadelphia ER - TY - JOUR A1 - Karschuck, Tobias A1 - Poghossian, Arshak A1 - Ser, Joey A1 - Tsokolakyan, Astghik A1 - Achtsnicht, Stefan A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage JF - Sensors and Actuators B: Chemical N2 - Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed. KW - Field-effect biosensor KW - Capacitive model KW - Enzyme coverage KW - Multianalyte detection KW - Penicillin Y1 - 2024 U6 - http://dx.doi.org/10.1016/j.snb.2024.135530 SN - 0925-4005 (Print) SN - 1873-3077 (Online) N1 - Corresponding Author: Michael J. Schöning VL - 408 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Karschuck, Tobias A1 - Schmidt, Stefan A1 - Achtsnicht, Stefan A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Multiplexing system for automated characterization of a capacitive field-effect sensor array JF - Physica Status Solidi A N2 - In comparison to single-analyte devices, multiplexed systems for a multianalyte detection offer a reduced assay time and sample volume, low cost, and high throughput. Herein, a multiplexing platform for an automated quasi-simultaneous characterization of multiple (up to 16) capacitive field-effect sensors by the capacitive–voltage (C–V) and the constant-capacitance (ConCap) mode is presented. The sensors are mounted in a newly designed multicell arrangement with one common reference electrode and are electrically connected to the impedance analyzer via the base station. A Python script for the automated characterization of the sensors executes the user-defined measurement protocol. The developed multiplexing system is tested for pH measurements and the label-free detection of ligand-stabilized, charged gold nanoparticles. KW - Capacitive field-effect sensor KW - Gold nanoparticles KW - Label-free detection KW - Multicell KW - Multiplexing Y1 - 2023 U6 - http://dx.doi.org/10.1002/pssa.202300265 SN - 1862-6300 (Print) SN - 1862-6319 (Online) N1 - Corresponding author: Michael Josef Schöning VL - 220 IS - 22 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kassab, T. A1 - Han, Y. A1 - Poghossian, Arshak A1 - Ingebrandt, S. A1 - Offenhäusser, A. A1 - Schöning, Michael Josef T1 - Detection of layerby-layer adsorbed polyelectrolytes by means of field-effect based capacitive EIS structures JF - Biomedizinische Technik. 49 (2004), H. 2 Y1 - 2004 SN - 0932-4666 SP - 1034 EP - 1035 ER - TY - CHAP A1 - Katz, Eugenii A1 - Willner, Itamar T1 - Magneto-controlled quantized electron transfer to surface-confined redox units and metal nanoparticles N2 - Hydrophobic magnetic nanoparticles (NPs) consisting of undecanoate-capped magnetite (Fe3O4, average diameter ca. 5 nm) are used to control quantized electron transfer to surface-confined redox units and metal NPs. A two-phase system consisting of an aqueous electrolyte solution and a toluene phase that includes the suspended undecanoatecapped magnetic NPs is used to control the interfacial properties of the electrode surface. The attracted magnetic NPs form a hydrophobic layer on the electrode surface resulting in the change of the mechanisms of the surface-confined electrochemical processes. A quinone-monolayer modified Au electrode demonstrates an aqueous-type of the electrochemical process (2e-+2H+ redox mechanism) for the quinone units in the absence of the hydrophobic magnetic NPs, while the attraction of the magnetic NPs to the surface results in the stepwise single-electron transfer mechanism characteristic of a dry nonaqueous medium. Also, the attraction of the hydrophobic magnetic NPs to the Au electrode surface modified with Au NPs (ca. 1.4 nm) yields a microenvironment with a low dielectric constant that results in the single-electron quantum charging of the Au NPs. KW - Biosensor KW - Nanoparticles KW - magnetic particles KW - quantum charging KW - modified electrode Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1528 ER - TY - JOUR A1 - Katz, Evgeny A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics JF - Analytical and Bioanalytical Chemistry N2 - The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a “filter” system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s00216-016-0079-7 SN - 1618-2650 VL - 409 SP - 81 EP - 94 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kaul, D. K. A1 - Koshkaryev, A. A1 - Artmann, Gerhard A1 - Barshtein, G. A1 - Yedgar, S. T1 - Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistance JF - American Journal of Physiology : Heart and Circulation Physiology . 295 (2008), H. 4 Y1 - 2008 SN - 1522-1539 VL - 295 IS - 4 SP - H1788 EP - H1793 ER - TY - JOUR A1 - Kaulen, Lars A1 - Schwabedal, Justus T. C. A1 - Schneider, Jules A1 - Ritter, Philipp A1 - Bialonski, Stephan T1 - Advanced sleep spindle identification with neural networks JF - Scientific Reports N2 - Sleep spindles are neurophysiological phenomena that appear to be linked to memory formation and other functions of the central nervous system, and that can be observed in electroencephalographic recordings (EEG) during sleep. Manually identified spindle annotations in EEG recordings suffer from substantial intra- and inter-rater variability, even if raters have been highly trained, which reduces the reliability of spindle measures as a research and diagnostic tool. The Massive Online Data Annotation (MODA) project has recently addressed this problem by forming a consensus from multiple such rating experts, thus providing a corpus of spindle annotations of enhanced quality. Based on this dataset, we present a U-Net-type deep neural network model to automatically detect sleep spindles. Our model’s performance exceeds that of the state-of-the-art detector and of most experts in the MODA dataset. We observed improved detection accuracy in subjects of all ages, including older individuals whose spindles are particularly challenging to detect reliably. Our results underline the potential of automated methods to do repetitive cumbersome tasks with super-human performance. Y1 - 2022 U6 - http://dx.doi.org/10.1038/s41598-022-11210-y SN - 2045-2322 N1 - Corresponding author: Stephan Bialonski VL - 12 IS - Article number: 7686 SP - 1 EP - 10 PB - Springer Nature CY - London ER - TY - THES A1 - Kelemen, Christina T1 - Analyse des phasensprungartigen Einsetzens der Passage humaner Erythrozyten durch Mikropipetten bei kritischen Temperaturen Y1 - 1999 N1 - Zugl.: Düsseldorf, Univ., Diss., 1999 ; Forschungszentrum Jülich: Berichte des Forschungszentrums Jülich ; 3667 PB - Forschungszentrum, Zentralbibliothek CY - Jülich ER - TY - CHAP A1 - Kern, Alexander A1 - Dikta, Gerhard T1 - Probability of damage of electrical and electronic systems due to indirect lightning flashes - investigation of data from German insurance companies N2 - In the presented paper data collected from the field related to damage statistics of electrical and electronic apparatus in household are reported and investigated. These damages (total number approx. 74000 cases), registered by five German insurance companies in 2005 and 2006, were adviced by customers as caused by lightning overvoltages. With the use of stochastical methods it is possible, to reasses the collected data and to distinguish between cases, which are with high probability caused by lightning overvoltages, and those, which are not. If there was an indication for a direct strike, this case was excluded, so the focus was only on indirect lightning flashes, i.e. only flashes to ground near the structure and flashes to or nearby an incoming service line were investigated. The data from the field contain the location of damaged apparatus (residence of the policy holder) and the distances of the nearest cloud-to-ground stroke to the location of the damage registered by the German lightning location network BLIDS at the date of damage. The statistical data along with some complementary numerical simulations allow to verify the correspondence of the Standards rules used for IEC 62305-2 with the field data and to define some correction needs. The results could lead to a better understanding whether a damage reported to an insurance company is really caused by indirect lightning, or not. KW - Blitzschutz KW - lightning flash Y1 - 2009 ER - TY - JOUR A1 - Kern, Alexander A1 - Schelthoff, Christof A1 - Mathieu, Moritz T1 - Detaillierte Berechnung der Einfangwirksamkeiten von Fangeinrichtungen JF - Elektro-Praktiker N2 - Im Beitrag wird zunächst das Verfahren eines dynamischen elektro-geometrischen Modells vorgestellt. Dieses arbeitet im Gegensatz zum klassischen Blitzkugel-Verfahren nicht mit konstanten Radien; vielmehr wird der Radius der Blitzkugel variiert. Dabei werden ausschließlich vorhandene und in internationalen Normen anerkannte Ergebnisse, blitzphysikalische Grundlagen und Untersuchungen verwendet, und auf deren Grundlage ein numerisches Verfahren erarbeitet. Mit dem dynamischen elektro-geometrischen Modell werden dann einige Beispiele des Schutzes mit Fangstangen, die gemäß dem klassischen Blitzkugel-Verfahren nach DIN EN 62305-3 für die Schutzklassen I – II – III – IV geplant sind, untersucht. Es wird gezeigt, dass die Einfangwirksamkeiten wesentlich höher sind als in der Normenreihe DIN EN 62305 selbst angegeben. Grund dafür ist die Tatsache, dass das Blitzkugel-Verfahren sehr konservativ aufgebaut ist und dem Planer von Blitzschutzsystemen nur die möglichen Stellen für einen Einschlag aufzeigt, ohne eine Bewertung der Einschlagshäufigkeit zu liefern. Andererseits bedeutet dies jedoch, dass man mit dem klassischen Blitzkugel-Verfahren stets auf der „sicheren Seite“ liegt. Y1 - 2012 SN - 0013-5569 VL - 66 IS - 4 PB - Huss Medien CY - Berlin ER - TY - JOUR A1 - Ketelhut, Maike A1 - Brügge, G. M. A1 - Göll, Fabian A1 - Braunstein, Bjoern A1 - Albracht, Kirsten A1 - Abel, Dirk T1 - Adaptive iterative learning control of an industrial robot during neuromuscular training JF - IFAC PapersOnLine N2 - To prevent the reduction of muscle mass and loss of strength coming along with the human aging process, regular training with e.g. a leg press is suitable. However, the risk of training-induced injuries requires the continuous monitoring and controlling of the forces applied to the musculoskeletal system as well as the velocity along the motion trajectory and the range of motion. In this paper, an adaptive norm-optimal iterative learning control algorithm to minimize the knee joint loadings during the leg extension training with an industrial robot is proposed. The response of the algorithm is tested in simulation for patients with varus, normal and valgus alignment of the knee and compared to the results of a higher-order iterative learning control algorithm, a robust iterative learning control and a recently proposed conventional norm-optimal iterative learning control algorithm. Although significant improvements in performance are made compared to the conventional norm-optimal iterative learning control algorithm with a small learning factor, for the developed approach as well as the robust iterative learning control algorithm small steady state errors occur. KW - Iterative learning control KW - Robotic rehabilitation KW - Adaptive control Y1 - 2020 U6 - http://dx.doi.org/10.1016/j.ifacol.2020.12.741 SN - 2405-8963 VL - 53 IS - 2 SP - 16468 EP - 16475 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Ketelhut, Maike A1 - Göll, Fabian A1 - Braunstein, Bjoern A1 - Albracht, Kirsten A1 - Abel, Dirk T1 - Iterative learning control of an industrial robot for neuromuscular training T2 - 2019 IEEE Conference on Control Technology and Applications N2 - Effective training requires high muscle forces potentially leading to training-induced injuries. Thus, continuous monitoring and controlling of the loadings applied to the musculoskeletal system along the motion trajectory is required. In this paper, a norm-optimal iterative learning control algorithm for the robot-assisted training is developed. The algorithm aims at minimizing the external knee joint moment, which is commonly used to quantify the loading of the medial compartment. To estimate the external knee joint moment, a musculoskeletal lower extremity model is implemented in OpenSim and coupled with a model of an industrial robot and a force plate mounted at its end-effector. The algorithm is tested in simulation for patients with varus, normal and valgus alignment of the knee. The results show that the algorithm is able to minimize the external knee joint moment in all three cases and converges after less than seven iterations. KW - Knee KW - Training KW - Load modeling KW - Force KW - Iterative learning control Y1 - 2019 SN - 978-1-7281-2767-5 (ePub) SN - 978-1-7281-2766-8 (USB) SN - 978-1-7281-2768-2 (PoD) U6 - http://dx.doi.org/10.1109/CCTA.2019.8920659 N1 - 2019 IEEE Conference on Control Technology and Applications (CCTA) Hong Kong, China, August 19-21, 2019 PB - IEEE CY - New York ER - TY - JOUR A1 - Ketelhut, Maike A1 - Göll, Fabian A1 - Braunstein, Björn A1 - Albracht, Kirsten A1 - Abel, Dirk T1 - Comparison of different training algorithms for the leg extension training with an industrial robot JF - Current Directions in Biomedical Engineering N2 - In the past, different training scenarios have been developed and implemented on robotic research platforms, but no systematic analysis and comparison have been done so far. This paper deals with the comparison of an isokinematic (motion with constant velocity) and an isotonic (motion against constant weight) training algorithm. Both algorithms are designed for a robotic research platform consisting of a 3D force plate and a high payload industrial robot, which allows leg extension training with arbitrary six-dimensional motion trajectories. In the isokinematic as well as the isotonic training algorithm, individual paths are defined i n C artesian s pace by sufficient s upport p oses. I n t he i sotonic t raining s cenario, the trajectory is adapted to the measured force as the robot should only move along the trajectory as long as the force applied by the user exceeds a minimum threshold. In the isotonic training scenario however, the robot’s acceleration is a function of the force applied by the user. To validate these findings, a simulative experiment with a simple linear trajectory is performed. For this purpose, the same force path is applied in both training scenarios. The results illustrate that the algorithms differ in the force dependent trajectory adaption. KW - Rehabilitation Technology and Prosthetics KW - Surgical Navigation and Robotics Y1 - 2018 U6 - http://dx.doi.org/10.1515/cdbme-2018-0005 SN - 2364-5504 VL - 4 IS - 1 SP - 17 EP - 20 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Ketelhut, Maike A1 - Kolditz, Melanie A1 - Göll, Fabian A1 - Braunstein, Bjoern A1 - Albracht, Kirsten A1 - Abel, Dirk T1 - Admittance control of an industrial robot during resistance training JF - IFAC-PapersOnLine N2 - Neuromuscular strength training of the leg extensor muscles plays an important role in the rehabilitation and prevention of age and wealth related diseases. In this paper, we focus on the design and implementation of a Cartesian admittance control scheme for isotonic training, i.e. leg extension and flexion against a predefined weight. For preliminary testing and validation of the designed algorithm an experimental research and development platform consisting of an industrial robot and a force plate mounted at its end-effector has been used. Linear, diagonal and arbitrary two-dimensional motion trajectories with different weights for the leg extension and flexion part are applied. The proposed algorithm is easily adaptable to trajectories consisting of arbitrary six-dimensional poses and allows the implementation of individualized trajectories. KW - Assistive technology KW - Rehabilitation engineering KW - Human-Computer interaction KW - Automatic control Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.ifacol.2019.12.102 SN - 2405-8963 N1 - 14th IFAC Symposium on Analysis, Design, and Evaluation of Human Machine Systems HMS 2019 Tallinn, Estonia, 16–91 September 2019 VL - 52 IS - 19 SP - 223 EP - 228 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Keusgen, M. A1 - Jünger, M. A1 - Knobbe, D.-T. A1 - Kloock, Joachim P. A1 - Schöning, Michael Josef T1 - Entwicklung eines potentiometrischen Cyanid-Biosensors auf der Basis von EIS-Strukturen JF - Sensoren für zukünftige Hochtechnologien und Neuentwicklungen für die Verfahrenstechnik / 6. Dresdner Sensor-Symposium, 8. - 10. Dezember 2003, Dresden. Jörg Peter Baselt; Gerald Gerlach (Hg.) Y1 - 2003 SN - 3-935712-92-8 SP - 235 EP - 238 PB - w.e.b.-Univ.-Verl. CY - Dresden ER - TY - JOUR A1 - Keusgen, M. A1 - Jünger, M. A1 - Krest, I. A1 - Schöning, Michael Josef T1 - Development of a biosensor specific for cysteine sulfoxides JF - Biosensors & Bioelectronics. 18 (2003), H. 5-6 Y1 - 2003 SN - 0956-5663 SP - 805 EP - 812 ER - TY - JOUR A1 - Keusgen, M. A1 - Jünger, M. A1 - Schöning, Michael Josef T1 - Biosensoric detection of the cysteine sulphoxide alliin JF - Book of abstracts / ed. by J. Saneistr. Y1 - 2002 SN - 80-01-02576-4 N1 - Eurosensors ; (16, 2002, Praha) SP - 1175 EP - 1178 PB - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement CY - Prague ER - TY - JOUR A1 - Keusgen, M. A1 - Kloock, Joachim P. A1 - Knobbe, D.-T. A1 - Jünger, M. A1 - Krest, I. A1 - Goldbach, M. A1 - Klein, W. A1 - Schöning, Michael Josef T1 - Direct determination of cyanides by potentiometric biosensors JF - Sensors and Actuators B. 103 (2004), H. 1-2 Y1 - 2004 SN - 0925-4005 SP - 380 EP - 385 ER - TY - JOUR A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Strategies for biosensoric detection of potential drugs in nature JF - Biomedizinische Technik. 49 (2004), H. 2 Y1 - 2004 SN - 0932-4666 SP - 1004 EP - 1005 ER - TY - JOUR A1 - Keusgen, Michael A1 - Jünger, Martina A1 - Krest, Ingo A1 - Schöning, Michael Josef T1 - Biosensoric detection of the cysteine sulphoxide alliin JF - Sensors and Actuators B. 95 (2003), H. 1-3 Y1 - 2003 SN - 0925-4005 SP - 297 EP - 302 ER - TY - JOUR A1 - Keutmann, Sabine A1 - Staat, Manfred A1 - Laack, Walter van T1 - Untersuchung der thermischen Auswirkung von therapeutischem Ultraschall N2 - Zusammenfassung: In der Orthopädie zählt der therapeutische Ultraschall als Mittel zur Prävention und Therapiebegleitung. Er hat mechanische, thermische und physiko-chemische Auswirkungen auf den menschlichen Körper. Um mehr Erkenntnisse über die thermischen Auswirkungen zu erlangen, wurden Versuche an einem Hydrogel-Phantom und an Probanden durchgeführt. Dabei entstand eine signifikante Erwärmung des Gewebes, welche beim Probandenversuch an der Oberfläche und beim Hydrogelversuch in der Tiefe gemessen wurde. Summary: In orthopaedics, therapeutic ultrasound is a tool of prevention and therapy support. It has mechanical, thermal and physico-chemical effects on the human body. Tests with a hydrogel phantom and with human probands have been performed in order to obtain more knowledge about their thermal effects. Both tests measured temperature increases in cell tissue, on the surface with the human proband test and in depth with the hydrogel phantom test. T2 - Research about the thermal effects of therapeutic ultrasound Y1 - 2018 SN - 2193-5793 SN - 2193-5785 (Druckausgabe) VL - 7 IS - 10 SP - 518 EP - 522 PB - Deutscher Ärzte-Verl. CY - Köln ER - TY - JOUR A1 - Khaydukova, M. M. A1 - Zadorozhnaya, O. A. A1 - Kirsanov, D. O. A1 - Iken, Heiko A1 - Rolka, David A1 - Schöning, Michael Josef A1 - Babain, V. A. A1 - Vlasov, Yu. G. A1 - Legin, A. V. T1 - Multivariate processing of atomic-force microscopy images for detection of the response of plasticized polymeric membranes JF - Russian journal of applied chemistry N2 - The possibility of using the atomic-force microscopy as a method for detection of the analytical signal from plasticized polymeric sensor membranes was analyzed. The surfaces of cadmium-selective membranes based on two polymeric matrices were examined. The digital images were processed with multivariate image analysis techniques. A correlation was found between the surface profile of an ion-selective membrane and the concentration of the ion in solution. Y1 - 2014 U6 - http://dx.doi.org/10.1134/S1070427214030112 SN - 1608-3296 (E-Journal); 1070-4272 (Print) VL - 87 IS - 3 SP - 307 EP - 314 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Khodaverdi, M. A1 - Chatziioannou, A. F. A1 - Weber, S. A1 - Ziemons, Karl A1 - Halling, H. A1 - Pietrzyk, U. T1 - Investigation of different MicroCT scanner configurations by GEANT4 simulations JF - IEEE Transactions on Nuclear Science N2 - This study has been performed to design the combination of the new ClearPET (ClearPET is a trademark of the Crystal Clear Collaboration), a small animal positron emission tomography (PET) system, with a micro-computed tomography (microCT) scanner. The properties of different microCT systems have been determined by simulations based on GEANT4. We will demonstrate the influence of the detector material and the X-ray spectrum on the obtained contrast. Four different detector materials (selenium, cadmium zinc telluride, cesium iodide and gadolinium oxysulfide) and two X-ray spectra (a molybdenum and a tungsten source) have been considered. The spectra have also been modified by aluminum filters of varying thickness. The contrast between different tissue types (water, air, brain, bone and fat) has been simulated by using a suitable phantom. The results indicate the possibility to improve the image contrast in microCT by an optimized combination of the X-ray source and detector material. Y1 - 2005 SN - 0018-9499 VL - 52 IS - 1 SP - 188 EP - 192 ER - TY - JOUR A1 - Khodaverdi, M. A1 - Chaziioannou, A. F. A1 - Weber, S. A1 - Ziemons, Karl A1 - Halling, H. A1 - Pietrzyk, U. T1 - Investigation of different microCT scanner configurations by GEANT4 simulations JF - 2003 IEEE Nuclear Science Symposium Conference Record, Vol. 4 N2 - This study has been performed to design the combination of the new ClearPET TM (ClearPET is a trademark of the Crystal Clear Collaboration), a small animal Positron Emission Tomography (PET) system, with a microComputed Tomography (microCT) scanner. The properties of different microCT systems have been determined by simulations based on GEANT4. We demonstrate the influence of the detector material and the X-ray spectrum on the obtained contrast. Four different detector materials (selenium, cadmium zinc telluride, cesium iodide and gadolinium oxysulfide) and two X-ray spectra (a molybdenum and a tungsten source) have been considered. The spectra have also been modified by aluminum filters of varying thickness. The contrast between different tissue types (water, air, brain, bone and fat) has been simulated by using a suitable phantom. The results indicate the possibility to improve the image contrast in microCT by an optimized combination of the X-ray source and detector material. Y1 - 2004 SN - 1082-3654 SP - 2989 EP - 2993 ER - TY - JOUR A1 - Khodaverdi, M. A1 - Pauly, F. A1 - Schroder, G. A1 - Ziemons, Karl A1 - Sievering, R. A1 - Halling, H. T1 - Preliminary studies of a micro-CT for a combined small animal PET/CT scanner JF - 2001 IEEE Nuclear Science Symposium Conference Record, Vol. 3 N2 - We are developing an X-ray computed tomography (CT) system which will be combined with a high resolution animal PET system. This permits acquisition of both molecular and anatomical images in a single machine. In particular the CT will also be utilized for the quantification of the animal PET data by providing accurate data for attenuation correction. A first prototype has been built using a commercially available plane silicon diode detector. A cone-beam reconstruction provides the images using the Feldkamp algorithm. First measurements with this system have been performed on a mouse. It could be shown that the CT setup fulfils all demands for a high quality image of the skeleton of the mouse. It is also suited for soft tissue measurements. To improve contrast and resolution and to acquire the X-ray energy further development of the system, especially the use of semiconductor detectors and iterative reconstruction algorithms are planned. Y1 - 2002 SN - 1082-3654 SP - 1605 EP - 1606 ER - TY - JOUR A1 - Khodaverdi, M. A1 - Weber, S. A1 - Streun, M. A1 - Parl, C. A1 - Ziemons, Karl T1 - High resolution imaging with ClearPET™ Neuro - first animal images JF - 2005 IEEE Nuclear Science Symposium Conference Record, Vol. 3 N2 - The ClearPET™ Neuro is the first full ring scanner within the Crystal Clear Collaboration (CCC). It consists of 80 detector modules allocated to 20 cassettes. LSO and LuYAP:Ce crystals in phoswich configuration in combination with position sensitive photomultiplier tubes are used to achieve high sensitivity and realize the acquisition of the depth of interaction (DOI) information. The complete system has been tested concerning the mechanical and electronical stability and interplay. Moreover, suitable corrections have been implemented into the reconstruction procedure to ensure high image quality. We present first results which show the successful operation of the ClearPET™ Neuro for artefact free and high resolution small animal imaging. Based on these results during the past few months the ClearPET™ Neuro System has been modified in order to optimize the performance. Y1 - 2006 SN - 1082-3654 SP - 1641 EP - 1644 ER - TY - CHAP A1 - Kirchhof, M. A1 - Kraft, Bodo T1 - UML-based modeling of architectural knowledge and design N2 - IASSE-2004 - 13th International Conference on Intelligent and Adaptive Systems and Software Engineering eds. W. Dosch, N. Debnath, pp. 245-250, ISCA, Cary, NC, 1-3 July 2004, Nice, France We introduce a UML-based model for conceptual design support in civil engineering. Therefore, we identify required extensions to standard UML. Class diagrams are used for elaborating building typespecific knowledge: Object diagrams, implicitly contained in the architect’s sketch, are validated against the defined knowledge. To enable the use of industrial, domain-specific tools, we provide an integrated conceptual design extension. The developed tool support is based on graph rewriting. With our approach architects are enabled to deal with semantic objects during early design phase, assisted by incremental consistency checks. KW - UML KW - UML KW - Unified Modeling Language KW - UML KW - Unified Modeling Language Y1 - 2004 ER - TY - JOUR A1 - Kirchhof, Michael A1 - Kraft, Bodo T1 - Hybrides Vorgehensmodell : Agile und klassische Methoden im Projekt passend kombinieren JF - ProjektMagazin N2 - Agil ist im Trend und immer mehr Unternehmen, die ihre Projekte bisher nach klassischen Prinzipien durchführten, denken über den Einsatz agiler Methoden nach. Doch selbst wenn die Organisation bereits beide Philosophien unterstützt, gilt für ein Projekt meist die klare Vorgabe: agil oder klassisch. Es gibt aber noch einen anderen Ansatz, mit diesen "unterschiedlichen Welten" umzugehen: Und zwar die beiden Philosophien innerhalb eines Projekts zu kombinieren. Wie dies in der Praxis aussehen und gelingen kann, zeigen Dr. Michael Kirchhof und Prof. Dr. Bodo Kraft in diesem Beitrag. Y1 - 2012 IS - 11 SP - 11 S. PB - Berleb Media CY - Taufkirchen ER - TY - CHAP A1 - Kirchhof, Michael A1 - Kraft, Bodo T1 - Dogmatisches „Entweder agil oder klassisch" im Projektmanagement hat ausgedient - die richtige Mischung macht's T2 - Projekt-Sternstunden : strahlende Erfolge durch Kompetenz Y1 - 2011 SN - 978-3-924841-60-7 N1 - PM-Forum <28, 2011, Nürnberg> ; PM-Forum 2011, 28. Internationales Deutsches Projektmanagement-Forum ; Nürnberg, 25. - 26.10.2011 ; Tagungsband SP - 414 EP - 425 PB - GPM CY - Nürnberg ER - TY - CHAP A1 - Kirchner, Patrick A1 - Henkel, H. A1 - Näther, Niko A1 - Spelthahn, H. A1 - Schneider, A. A1 - Berger, J. A1 - Kolstad, J. A1 - Friedrich, P. A1 - Schöning, Michael Josef T1 - RFID-basiertes Sensorsystem zur Realisierung intelligenter Verpackungen für die Nahrungsmittelindustrie T2 - KMU - innovativ: IKT 2008. CD-ROM : BMBF-Statustagung KMU - innovativ: IKT, Darmstadt, 17. - 18. Nov. 2008 Y1 - 2008 IS - CD-ROM-Ausg. PB - BMBF CY - Berlin ER - TY - JOUR A1 - Kirchner, Patrick A1 - Li, B. A1 - Spelthahn, H. A1 - Henkel, H. A1 - Friedrich, P. A1 - Kolstad, J. A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Thin-film calorimetric H2O2 gas sensor for the validation of germicidal effectivity in aseptic filling processes JF - Procedia Chemistry. 1 (2009), H. 1 Y1 - 2009 SN - 1876-6196 N1 - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23 SP - 983 EP - 986 ER - TY - JOUR A1 - Kirchner, Patrick A1 - Li, B. A1 - Spelthahn, H. A1 - Henkel, H. A1 - Schneider, A. A1 - Kolstad, J. A1 - Friedrich, P. A1 - Schöning, Michael Josef T1 - Realisierung eines miniaturisierten Gassensors in Chiptechnologie basierend auf einer Dünnschicht-Thermosäule zur H2O2-Detektion in aseptischen Abfüllanlagen JF - 9. Dresdner Sensor-Symposium : Dresden, 07.-09. Dezember 2009 / Gerlach, Gerald ; Hauptmann, Peter [Hrsg.] Y1 - 2009 SN - 978-3-941298-44-6 N1 - Dresdner Sensor-Symposium ; (9, 2009, Dresden) SP - 293 EP - 296 PB - TUDpress CY - Dresden ER - TY - JOUR A1 - Kirchner, Patrick A1 - Li, Bin A1 - Spelthahn, Heiko A1 - Henkel, Hartmut A1 - Schneider, Andreas A1 - Friedrich, Peter A1 - Kolstad, Jens A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Thin-film calorimetric H2O2 gas sensor for the validation of germicidal effectivity in aseptic filling processes JF - Sensors and Actuators B: Chemical. 154 (2011), H. 2 Y1 - 2011 SN - 1873-3077 N1 - EUROSENSORS XXIII SP - 257 EP - 263 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Friedrich, Peter A1 - Berger, Jörg A1 - Rysstad, Gunnar A1 - Schöning, Michael Josef A1 - Keusgen, Michael T1 - Realisation of a calorimetric gas sensor on polyimide foil for applications in aseptic food industry JF - Sensors and Actuators B: Chemical N2 - A calorimetric gas sensor is presented for the monitoring of vapour-phase H2O2 at elevated temperature during sterilisation processes in aseptic food industry. The sensor was built up on a flexible polyimide foil (thickness: 25 μm) that has been chosen due to its thermal stability and low thermal conductivity. The sensor set-up consists of two temperature-sensitive platinum thin-film resistances passivated by a layer of SU-8 photo resist and catalytically activated by manganese(IV) oxide. Instead of an active heating structure, the calorimetric sensor utilises the elevated temperature of the evaporated H2O2 aerosol. In an experimental test rig, the sensor has shown a sensitivity of 4.78 °C/(%, v/v) in a H2O2 concentration range of 0%, v/v to 8%, v/v. Furthermore, the sensor possesses the same, unchanged sensor signal even at varied medium temperatures between 210 °C and 270 °C of the gas stream. At flow rates of the gas stream from 8 m3/h to 12 m3/h, the sensor has shown only a slightly reduced sensitivity at a low flow rate of 8 m3/h. The sensor characterisation demonstrates the suitability of the calorimetric gas sensor for monitoring the efficiency of industrial sterilisation processes. KW - Sterilisation process KW - Hydrogen peroxide KW - Polyimide KW - Calorimetric gas sensor Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.snb.2011.01.032 SN - 0925-4005 N1 - Part of special issue "Eurosensors XXIV, 2010" VL - 170 SP - 60 EP - 66 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Friedrich, Peter A1 - Berger, Jörg A1 - Suso, Henri-Pierre A1 - Kupyna, Andriy A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Optimisation and fabrication of a calorimetric gas sensor built up on a polyimide substrate for H2O2 monitoring JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1235 EP - 1240 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Friedrich, Peter A1 - Rysstad, G. A1 - Berger, J. A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Realization of a calorimetric gas sensor on polyimide foil for applications in aseptic food industry JF - Procedia Engineering. 5 (2010) Y1 - 2010 SN - 1877-7058 N1 - Eurosensor XXIV Conference SP - 264 EP - 267 ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Suco, Henri-Pierre A1 - Rysstad, Gunnar A1 - Schöning, Michael Josef T1 - Monitoring the microbicidal effectiveness of gaseous hydrogen peroxide in sterilisation processes by means of a calorimetric gas sensor JF - Food control N2 - In the present work, a novel method for monitoring sterilisation processes with gaseous H2O2 in combination with heat activation by means of a specially designed calorimetric gas sensor was evaluated. Therefore, the sterilisation process was extensively studied by using test specimens inoculated with Bacillus atrophaeus spores in order to identify the most influencing process factors on its microbicidal effectiveness. Besides the contact time of the test specimens with gaseous H2O2 varied between 0.2 and 0.5 s, the present H2O2 concentration in a range from 0 to 8% v/v (volume percent) had a strong influence on the microbicidal effectiveness, whereas the change of the vaporiser temperature, gas flow and humidity were almost negligible. Furthermore, a calorimetric H2O2 gas sensor was characterised in the sterilisation process with gaseous H2O2 in a wide range of parameter settings, wherein the measurement signal has shown a linear response against the H2O2 concentration with a sensitivity of 4.75 °C/(% v/v). In a final step, a correlation model by matching the measurement signal of the gas sensor with the microbial inactivation kinetics was established that demonstrates its suitability as an efficient method for validating the microbicidal effectiveness of sterilisation processes with gaseous H2O2. KW - hydrogen peroxide KW - sterilisation KW - Bacillus atrophaeus KW - calorimetric gas sensor Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.foodcont.2012.11.048 SN - 0956-7135 VL - 31 IS - 2 SP - 530 EP - 538 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Suso, Henri-Pierre A1 - Rysstad, Gunnar A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Towards a wireless sensor system for real-time H2O2 monitoring in aseptic food processes JF - Physica status solidi (a) N2 - A wireless sensor system based on the industrial ZigBee standard for low-rate wireless networking was developed that enables real-time monitoring of gaseous H2O2 during the package sterilization in aseptic food processes. The sensor system consists of a remote unit connected to a calorimetric gas sensor, which was already established in former works, and an external base unit connected to a laptop computer. The remote unit was built up by an XBee radio frequency (RF) module for data communication and a programmable system-on-chip controller to read out the sensor signal and process the sensor data, whereas the base unit is a second XBee RF module. For the rapid H2O2 detection on various locations inside the package that has to be sterilized, a novel read-out strategy of the calorimetric gas sensor was established, wherein the sensor response is measured within the short sterilization time and correlated with the present H2O2 concentration. In an exemplary measurement application in an aseptic filling machinery, the suitability of the new, wireless sensor system was demonstrated, wherein the influence of the gas velocity on the H2O2 distribution inside a package was determined and verified with microbiological tests. KW - calorimetric gas sensor;hydrogen peroxide;wireless sensor system Y1 - 2013 U6 - http://dx.doi.org/10.1002/pssa.201200920 SN - 1862-6319 VL - 210 IS - 5 SP - 877 EP - 883 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Kirchner, Patrick A1 - Reisert, Steffen A1 - Pütz, Patrick A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Characterisation of polymeric materials as passivation layer for calorimetric H2O2 gas sensors JF - Physica Status Solidi (a) N2 - Calorimetric gas sensors for monitoring the H₂O₂ concentration at elevated temperatures in industrial sterilisation processes have been presented in previous works. These sensors are built up in form of a differential set-up of a catalytically active and passive temperature-sensitive structure. Although, various types of catalytically active dispersions have been studied, the passivation layer has to be established and therefore, chemically as well as physically characterised. In the present work, fluorinated ethylene propylene (FEP), perfluoralkoxy (PFA) and epoxy-based SU-8 photoresist as temperature-stable polymeric materials have been investigated for sensor passivation in terms of their chemical inertness against H₂O₂, their hygroscopic properties as well as their morphology. The polymeric materials were deposited via spin-coating on the temperature-sensitive structure, wherein spin-coated FEP and PFA show slight agglomerates. However, they possess a low absorption of humidity due to their hydrophobic surface, whereas the SU-8 layer has a closed surface but shows a slightly higher absorption of water. All of them were inert against gaseous H₂O₂ during the characterisation in H₂O₂ atmosphere that demonstrates their suitability as passivation layer for calorimetric H₂O₂ gas sensors. Y1 - 2012 U6 - http://dx.doi.org/10.1002/pssa.201100773 SN - 1862-6319 VL - 209 IS - 5 SP - 859 EP - 863 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kirchner, Patrick A1 - Spelthahn, H. A1 - Schöning, Michael Josef A1 - Henkel, H. A1 - Schneider, A. A1 - Friedrich, P. A1 - Kolstad, J. A1 - Berger, J. T1 - Realisierung eines Polyimid-basierten kalorimetrischen Gassensors zur Inline-Überwachung der H2O2-Konzentration in aseptischen Abfüllanlagen JF - Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA) Y1 - 2010 SN - 978-3-8007-3260-9 N1 - Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik SP - 607 EP - 612 PB - VDE Verlag CY - Berlin ER - TY - JOUR A1 - Kleefeld, A. A1 - Reißel, Martin T1 - The Levenberg–Marquardt method applied to a parameter estimation problem arising from electrical resistivity tomography JF - Applied Mathematics and Computation Y1 - 2011 SN - 0096-3003 VL - 217 IS - 9 SP - 4490 EP - 4501 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kleines, H. A1 - Erki, I. A1 - Ziemons, Karl A1 - Zwoll, K. ED - Lehmann, Thomas T1 - ATM- und Multimedia Pilotsystem im Rahmen des Projektes M-FIBRe Aufbau und Erfahrungen JF - Bildverarbeitung für die Medizin : Algorithmen - Systeme - Anwendungen Y1 - 1997 SN - 3-86073-519-5 N1 - Proceedings des Aachener Workshops am 8. u. 9. November 1996 ; PP_001 Posterpräsentation SP - 241 EP - 248 PB - Verl. der. Augustinus-Buchh. CY - Aachen ER - TY - JOUR A1 - Kloock, Joachim P. A1 - Moreno, Lia A1 - Bratov, A. A1 - Huachupoma, S. A1 - Xu, J. A1 - Wagner, Torsten A1 - Yoshinobu, T. A1 - Ermolenko, Y. A1 - Vlasov, Y. G. A1 - Schöning, Michael Josef T1 - PLD-prepared cadmium sensors based on chalcogenide glasses —ISFET, LAPS and μISE semiconductor structures JF - Sensors and Actuators B: Chemical. 118 (2006), H. 1-2 Y1 - 2006 SN - 0925-4005 N1 - Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers SP - 149 EP - 155 ER - TY - CHAP A1 - Kloock, Joachim P. A1 - Moreno, Lia A1 - Huachupoma, S. A1 - Xu, J. A1 - Wagner, Torsten A1 - Bratov, A. A1 - Doll, T. A1 - Vlasov, Y. A1 - Schöning, Michael Josef ED - Gerlach, Gerald T1 - Halbleiterbasierte Schwermetallsensorik auf der Basis von Chalkogenidgläsern für zukünftige „Lab on Chip“-Anwendungen T2 - 7. Dresdner Sensor-Symposium - Neue Herausforderungen und Anwendungen in der Sensortechnik Y1 - 2005 SN - 3-938863-29-3 SP - 221 EP - 224 PB - TUDpress, Verl. der Wissenschaften CY - Dresden ER - TY - JOUR A1 - Kloock, Joachim P. A1 - Mourzina, Y. A1 - Schubert, J. A1 - Ermelenko, Y. A1 - Schöning, Michael Josef T1 - Pulsed laser deposition: A tool for fabricating thin-film microsensors JF - Biomedizinische Technik. 49 (2004), H. 2 Y1 - 2004 SN - 0932-4666 SP - 1032 EP - 1033 ER - TY - JOUR A1 - Kloock, Joachim P. A1 - Mourzina, Y.G. A1 - Ermolenko, Y. A1 - Doll, T. A1 - Schubert, J. A1 - Schöning, Michael Josef T1 - Inorganic thin-film sensor membranes with PLD-prepared chalcogenide glasses: Challenges and implementation JF - Sensors. 4 (2004), H. 10 Y1 - 2004 SN - 1424-8220 SP - 156 EP - 162 ER - TY - JOUR A1 - Kloock, Joachim P. A1 - Mourzina, Y.G. A1 - Yoshinobu, T. A1 - Schubert, J. A1 - Schöning, Michael Josef T1 - Chalkogenidglassensoren für die Schwermetallanalytik JF - Sensoren und Mess-Systeme : Vorträge der 11. ITG/GMA-Fachtagung vom 11. bis 12. März 2002 in Ludwigsburg / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Wiss. Tagungsleitung: C. D. Kohl .... Y1 - 2002 SN - 3-8007-2675-0 N1 - Sensoren und Mess-Systeme 2002 SP - 395 EP - 398 PB - VDE-Verl. CY - Berlin [u.a.] ER - TY - JOUR A1 - Kloock, Joachim P. A1 - Poghossian, Arshak A1 - Schumacher, K. A1 - Rosenkranz, C. A1 - Schultze, J. W. A1 - Müller-Veggian, Mattea A1 - Schöning, Michael Josef T1 - Funktionsprüfung und Charakterisierung von ionensensitiven Feldeffekttransistoren (ISFETs) auf Waferebene mittels Mikrotropfenzelle für den zukünftigen Einsatz in der Sensorproduktion JF - Sensoren und Messsysteme 2006 : Vorträge der 13. ITG/GMA-Fachtagung vom 13. bis 14. März 2006 in Freiburg/Breisgau / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ; VDE/VDI-Gesellschaft Mess- und Automatisierungstechnik (GMA). Wiss. Tagungsleitung: L. M. Reindl Y1 - 2006 SN - 3-8007-2939-3 N1 - Fachtagung Sensoren und Messsysteme <13, 2006, Freiburg, Breisgau> SP - 257 EP - 260 PB - VDE-Verl. CY - Berlin ER - TY - CHAP A1 - Kloock, Joachim P. A1 - Schubert, J. A1 - Ermelenko, Y. A1 - Vlasov, Y. G. A1 - Bratov, A. A1 - Schöning, Michael Josef T1 - Thin-film sensors with chalcogenide glass materials – a general survey T2 - Biochemical sensing utilisation of micro- and nanotechnologies : Warsaw, [23rd - 26th] November 2005 / ed. by M. Mascini ... Y1 - 2006 SP - 92 EP - 97 CY - Warsaw ER - TY - CHAP A1 - Kloock, Joachim P. A1 - Schöning, Michael Josef T1 - Heavy metal detection with semiconductor devices based on PLD-prepared chalcogenide glass thin films T2 - Armenian Journal of Physics Y1 - 2007 SN - 1829-1171 SP - 95 EP - 98 ER - TY - CHAP A1 - Klöser, Lars A1 - Büsgen, André A1 - Kohl, Philipp A1 - Kraft, Bodo A1 - Zündorf, Albert ED - Conte, Donatello ED - Fred, Ana ED - Gusikhin, Oleg ED - Sansone, Carlo T1 - Explaining relation classification models with semantic extents T2 - DeLTA 2023: Deep Learning Theory and Applications N2 - In recent years, the development of large pretrained language models, such as BERT and GPT, significantly improved information extraction systems on various tasks, including relation classification. State-of-the-art systems are highly accurate on scientific benchmarks. A lack of explainability is currently a complicating factor in many real-world applications. Comprehensible systems are necessary to prevent biased, counterintuitive, or harmful decisions. We introduce semantic extents, a concept to analyze decision patterns for the relation classification task. Semantic extents are the most influential parts of texts concerning classification decisions. Our definition allows similar procedures to determine semantic extents for humans and models. We provide an annotation tool and a software framework to determine semantic extents for humans and models conveniently and reproducibly. Comparing both reveals that models tend to learn shortcut patterns from data. These patterns are hard to detect with current interpretability methods, such as input reductions. Our approach can help detect and eliminate spurious decision patterns during model development. Semantic extents can increase the reliability and security of natural language processing systems. Semantic extents are an essential step in enabling applications in critical areas like healthcare or finance. Moreover, our work opens new research directions for developing methods to explain deep learning models. KW - Relation classification KW - Natural language processing KW - Natural language understanding KW - Information extraction KW - Trustworthy artificial intelligence Y1 - 2023 SN - 978-3-031-39058-6 (Print) SN - 978-3-031-39059-3 (Online) U6 - http://dx.doi.org/10.1007/978-3-031-39059-3_13 N1 - 4th International Conference, DeLTA 2023, Rome, Italy, July 13–14, 2023. SP - 189 EP - 208 PB - Springer CY - Cham ER - TY - CHAP A1 - Klöser, Lars A1 - Kohl, Philipp A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - Multi-attribute relation extraction (MARE): simplifying the application of relation extraction T2 - Proceedings of the 2nd International Conference on Deep Learning Theory and Applications - DeLTA N2 - Natural language understanding’s relation extraction makes innovative and encouraging novel business concepts possible and facilitates new digitilized decision-making processes. Current approaches allow the extraction of relations with a fixed number of entities as attributes. Extracting relations with an arbitrary amount of attributes requires complex systems and costly relation-trigger annotations to assist these systems. We introduce multi-attribute relation extraction (MARE) as an assumption-less problem formulation with two approaches, facilitating an explicit mapping from business use cases to the data annotations. Avoiding elaborated annotation constraints simplifies the application of relation extraction approaches. The evaluation compares our models to current state-of-the-art event extraction and binary relation extraction methods. Our approaches show improvement compared to these on the extraction of general multi-attribute relations. Y1 - 2021 SN - 978-989-758-526-5 U6 - http://dx.doi.org/10.5220/0010559201480156 N1 - Proceedings of the 2nd International Conference on Deep Learning Theory and Applications, DeLTA2021, July 7-9, 2021 SP - 148 EP - 156 ER - TY - JOUR A1 - Knobbe, D.-T. A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Mourzina, Y. T1 - Charakterisierung von kapazitiven EMISSensoren mittels Impedanzspektroskopie, Kapazitäts-Spannungs- und Konstant-Kapazitäts-Messung JF - Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. März 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik Y1 - 2004 SN - 3-18-091829-2 N1 - Auch erschienen als: VDI-Berichte ; 1829 SP - 851 EP - 854 PB - VDI CY - Düsseldorf ER - TY - JOUR A1 - Knobe, M. A1 - Giesen, M. A1 - Plate, S. A1 - Gradl-Dietsch, G. A1 - Buecking, B. A1 - Eschbach, D. A1 - Laack, Walter van A1 - Pape, H.-C. T1 - The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale JF - European Journal Of Trauma And Emergency Surgery N2 - Purpose The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. Methods For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland–Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. Results The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = −0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points). Conclusion The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status. KW - Tinetti test KW - Mobility KW - Mobility tests KW - Ground-level falls KW - Elderly KW - Fall prevention KW - Co-managed care KW - Balance Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00068-016-0693-2 SN - 1863-9941 VL - 42 IS - 5 SP - 537 EP - 545 PB - Springer CY - Berlin ER - TY - CHAP A1 - Knott, Thomas C. A1 - Sofronia, Raluca E. A1 - Gerressen, Marcus A1 - Law, Yuen A1 - Davidescu, Arjana A1 - Savii, George G. A1 - Gatzweiler, Karl-Heinz A1 - Staat, Manfred A1 - Kuhlen, Torsten W. T1 - Preliminary bone sawing model for a virtual reality-based training simulator of bilateral sagittal split osteotomy T2 - Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789) N2 - Successful bone sawing requires a high level of skill and experience, which could be gained by the use of Virtual Reality-based simulators. A key aspect of these medical simulators is realistic force feedback. The aim of this paper is to model the bone sawing process in order to develop a valid training simulator for the bilateral sagittal split osteotomy, the most often applied corrective surgery in case of a malposition of the mandible. Bone samples from a human cadaveric mandible were tested using a designed experimental system. Image processing and statistical analysis were used for the selection of four models for the bone sawing process. The results revealed a polynomial dependency between the material removal rate and the applied force. Differences between the three segments of the osteotomy line and between the cortical and cancellous bone were highlighted. KW - Bone sawing KW - virtual reality KW - training simulator Y1 - 2014 SN - 978-3-319-12057-7 (Online) SN - 978-3-319-12056-0 (Print) U6 - http://dx.doi.org/10.1007/978-3-319-12057-7_1 SP - 1 EP - 10 PB - Springer CY - Cham ER - TY - JOUR A1 - Knox, Ronald A1 - Bruggemann, Andrea A1 - Gossmann, Matthias A1 - Thomas, Ulrich A1 - Horváth, András A1 - Dragicevic, Elena A1 - Stoelzle-Feix, Sonja A1 - Fertig, Niels A1 - Jung, Alexander A1 - Raman, Aravind Hariharan A1 - Staat, Manfred A1 - Linder, Peter T1 - Combining physiological relevance and throughput for in vitro cardiac contractility measurement JF - Biophysical Journal N2 - Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these. Y1 - 2020 U6 - http://dx.doi.org/10.1016/j.bpj.2019.11.3104 SN - 0006-3495 N1 - Raman, Arayind Hariharan im Artikel unter dem Namen: Raman, Alexander H. VL - 118 IS - Issue 3, Supplement 1 SP - 570a PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Koch, Claudia A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Wege, Christian T1 - Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors JF - Nanotheranostics N2 - The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts. Y1 - 2018 U6 - http://dx.doi.org/10.7150/ntno.22114 SN - 2206-7418 VL - 2 IS - 2 SP - 184 EP - 196 PB - Ivyspring CY - Sydney ER - TY - CHAP A1 - Koch, Claudia A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Schöning, Michael Josef ED - Wege, Christina T1 - TMV-Based Adapter Templates for Enhanced Enzyme Loading in Biosensor Applications T2 - Virus-Derived Nanoparticles for Advanced Technologies N2 - Nanotubular tobacco mosaic virus (TMV) particles and RNA-free lower-order coat protein (CP) aggregates have been employed as enzyme carriers in different diagnostic layouts and compared for their influence on biosensor performance. In the following, we describe a label-free electrochemical biosensor for improved glucose detection by use of TMV adapters and the enzyme glucose oxidase (GOD). A specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CP aggregates was achieved via bioaffinity binding. Glucose sensors with adsorptively immobilized [SA]-GOD, and with [SA]-GOD cross-linked with glutardialdehyde, respectively, were tested in parallel on the same sensor chip. Comparison of these sensors revealed that TMV adapters enhanced the amperometric glucose detection remarkably, conveying highest sensitivity, an extended linear detection range and fastest response times. These results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for applications in biosensorics and biochips. Here, we describe the fabrication and use of amperometric sensor chips combining an array of circular Pt electrodes, their loading with GOD-modified TMV nanotubes (and other GOD immobilization methods), and the subsequent investigations of the sensor performance. KW - Tobacco mosaic virus (TMV) KW - Coat protein KW - Enzyme nanocarrier KW - Glucose biosensor KW - Glucose oxidase Y1 - 2018 SN - 978-1-4939-7808-3 U6 - http://dx.doi.org/10.1007/978-1-4939-7808-3 N1 - Methods in Molecular Biology, vol 1776 SP - 553 EP - 568 PB - Humana Press CY - New York, NY ER - TY - JOUR A1 - Kodomskoi, Leonid A1 - Kotliar, Konstantin A1 - Schröder, Andreas A1 - Weiss, Michael A1 - Hille, Konrad T1 - Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter JF - Journal of Glaucoma Y1 - 2019 U6 - http://dx.doi.org/10.1097/IJG.0000000000001321 SN - 1057-0829 IS - Epub ahead of print PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - CHAP A1 - Kohl, Philipp A1 - Freyer, Nils A1 - Krämer, Yoka A1 - Werth, Henri A1 - Wolf, Steffen A1 - Kraft, Bodo A1 - Meinecke, Matthias A1 - Zündorf, Albert ED - Conte, Donatello ED - Fred, Ana ED - Gusikhin, Oleg ED - Sansone, Carlo T1 - ALE: a simulation-based active learning evaluation framework for the parameter-driven comparison of query strategies for NLP T2 - Deep Learning Theory and Applications. DeLTA 2023. Communications in Computer and Information Science N2 - Supervised machine learning and deep learning require a large amount of labeled data, which data scientists obtain in a manual, and time-consuming annotation process. To mitigate this challenge, Active Learning (AL) proposes promising data points to annotators they annotate next instead of a subsequent or random sample. This method is supposed to save annotation effort while maintaining model performance. However, practitioners face many AL strategies for different tasks and need an empirical basis to choose between them. Surveys categorize AL strategies into taxonomies without performance indications. Presentations of novel AL strategies compare the performance to a small subset of strategies. Our contribution addresses the empirical basis by introducing a reproducible active learning evaluation (ALE) framework for the comparative evaluation of AL strategies in NLP. The framework allows the implementation of AL strategies with low effort and a fair data-driven comparison through defining and tracking experiment parameters (e.g., initial dataset size, number of data points per query step, and the budget). ALE helps practitioners to make more informed decisions, and researchers can focus on developing new, effective AL strategies and deriving best practices for specific use cases. With best practices, practitioners can lower their annotation costs. We present a case study to illustrate how to use the framework. KW - Active learning KW - Query learning KW - Natural language processing KW - Deep learning KW - Reproducible research Y1 - 2023 SN - 978-3-031-39058-6 (Print) SN - 978-3-031-39059-3 (Online) U6 - http://dx.doi.org/978-3-031-39059-3 N1 - 4th International Conference, DeLTA 2023, Rome, Italy, July 13–14, 2023. SP - 235 EP - 253 PB - Springer CY - Cham ER - TY - CHAP A1 - Kohl, Philipp A1 - Schmidts, Oliver A1 - Klöser, Lars A1 - Werth, Henri A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - STAMP 4 NLP – an agile framework for rapid quality-driven NLP applications development T2 - Quality of Information and Communications Technology. QUATIC 2021 N2 - The progress in natural language processing (NLP) research over the last years, offers novel business opportunities for companies, as automated user interaction or improved data analysis. Building sophisticated NLP applications requires dealing with modern machine learning (ML) technologies, which impedes enterprises from establishing successful NLP projects. Our experience in applied NLP research projects shows that the continuous integration of research prototypes in production-like environments with quality assurance builds trust in the software and shows convenience and usefulness regarding the business goal. We introduce STAMP 4 NLP as an iterative and incremental process model for developing NLP applications. With STAMP 4 NLP, we merge software engineering principles with best practices from data science. Instantiating our process model allows efficiently creating prototypes by utilizing templates, conventions, and implementations, enabling developers and data scientists to focus on the business goals. Due to our iterative-incremental approach, businesses can deploy an enhanced version of the prototype to their software environment after every iteration, maximizing potential business value and trust early and avoiding the cost of successful yet never deployed experiments. KW - Machine learning KW - Process model KW - Natural language processing Y1 - 2021 SN - 978-3-030-85346-4 SN - 978-3-030-85347-1 U6 - http://dx.doi.org/10.1007/978-3-030-85347-1_12 N1 - International Conference on the Quality of Information and Communications Technology, QUATIC 2021, 8-11 September, Algarve, Portugal SP - 156 EP - 166 PB - Springer CY - Cham ER - TY - JOUR A1 - Kohler, Annette A1 - Kirschner-Hermanns, Ruth A1 - Staat, Manfred A1 - Brehmer, Bernhard T1 - Pathogenese, funktionelle und anatomische Aspekte der weiblichen Belastungsinkontinenz T1 - Female stress incontinence: aspects of pathogenesis and functional anatomy JF - Aktuelle Urologie N2 - Der vorliegende Artikel fokussiert sich auf die weibliche Belastungsinkontinenz als Insuffizienz der Speicherfunktion der Blase, auch wenn im klinischen Alltag die Harninkontinenz der Frau häufig verschiedene Ursachen hat und insbesondere eine Belastungsinkontinenz im Alter und bei neurologischer Komorbidität nur selten isoliert vorkommt. Das kleine Becken der Frau ist sowohl als Funktions- als auch als strukturelle Einheit zu betrachten. Dabei unterliegen bei der Frau Blase, Harnröhre, Gebärmutter und Enddarm sowie die muskulären und ligamentösen Strukturen des kleinen Beckens durch Fertilitätsphase, mögliche Schwangerschaften, Geburten und Menopausen-Phase, über das „normale Altern“ hinaus, gravierenden Veränderungen. This article focuses on female stress incontinence in the form of pelvic floor dysfunction and urethral sphincter deficiency, although isolated stress incontinence accounts for less than half of all incontinence cases. Especially in women of old age and those with neurological comorbidities, the causes of incontinence are mostly multifactorial. Also it has to be considered that the female bladder, urethra, uterus and rectum as well as the muscular and ligamentous structures of the female pelvis minor are affected by phases of fertility, possible pregnancies, births and menopause in addition to the normal ageing process. Y1 - 2018 U6 - http://dx.doi.org/10.1055/s-0043-120616 SN - 1438-8820 VL - 49 IS - 1 SP - 47 EP - 51 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Abel, Dirk A1 - Fasse, Alessandro A1 - Brüggemann, Gert-Peter A1 - Albracht, Kirsten T1 - Evaluation of foot position and orientation as manipulated variables to control external knee adduction moments in leg extension training JF - Computer methods and programs in biomedicine N2 - Background and Objective Effective leg extension training at a leg press requires high forces, which need to be controlled to avoid training-induced damage. In order to avoid high external knee adduction moments, which are one reason for unphysiological loadings on knee joint structures, both training movements and the whole reaction force vector need to be observed. In this study, the applicability of lateral and medial changes in foot orientation and position as possible manipulated variables to control external knee adduction moments is investigated. As secondary parameters both the medio-lateral position of the center of pressure and the frontal-plane orientation of the reaction force vector are analyzed. Methods Knee adduction moments are estimated using a dynamic model of the musculoskeletal system together with the measured reaction force vector and the motion of the subject by solving the inverse kinematic and dynamic problem. Six different foot conditions with varying positions and orientations of the foot in a static leg press are evaluated and compared to a neutral foot position. Results Both lateral and medial wedges under the foot and medial and lateral shifts of the foot can influence external knee adduction moments in the presented study with six healthy subjects. Different effects are observed with the varying conditions: the pose of the leg is changed and the direction and center of pressure of the reaction force vector is influenced. Each effect results in a different direction or center of pressure of the reaction force vector. Conclusions The results allow the conclusion that foot position and orientation can be used as manipulated variables in a control loop to actively control knee adduction moments in leg extension training. KW - External knee adduction moments KW - Manipulated variables KW - Inverse dynamic problem KW - Inverse kinematic problem KW - Musculoskeletal model Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.cmpb.2016.09.005 SN - 0169-2607 N1 - Part of special issue: "SI: Personalised Models and System Identification" VL - 171 SP - 81 EP - 86 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Albracht, Kirsten A1 - Brüggemann, Gert-Peter A1 - Abel, Dirk T1 - Isokinematic leg extension training with an industrial robot T2 - 6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore Y1 - 2016 U6 - http://dx.doi.org/10.1109/BIOROB.2016.7523750 SP - 950 EP - 955 ER - TY - JOUR A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Brüggemann, Gert-Peter A1 - Abel, Dirk A1 - Albracht, Kirsten T1 - Robotergestütztes System für ein verbessertes neuromuskuläres Aufbautraining der Beinstrecker JF - at - Automatisierungstechnik N2 - Neuromuskuläres Aufbautraining der Beinstrecker ist ein wichtiger Bestandteil in der Rehabilitation und Prävention von Muskel-Skelett-Erkrankungen. Effektives Training erfordert hohe Muskelkräfte, die gleichzeitig hohe Belastungen von bereits geschädigten Strukturen bedeuten. Um trainingsinduzierte Schädigungen zu vermeiden, müssen diese Kräfte kontrolliert werden. Mit heutigen Trainingsgeräten können diese Ziele allerdings nicht erreicht werden. Für ein sicheres und effektives Training sollen durch den Einsatz der Robotik, Sensorik, eines Regelkreises sowie Muskel-Skelett-Modellen Belastungen am Zielgewebe direkt berechnet und kontrolliert werden. Auf Basis zweier Vorstudien zu möglichen Stellgrößen wird der Aufbau eines robotischen Systems vorgestellt, das sowohl für Forschungszwecke als auch zur Entwicklung neuartiger Trainingsgeräte verwendet werden kann. Y1 - 2016 U6 - http://dx.doi.org/10.1515/auto-2016-0044 SN - 2196-677X VL - 64 IS - 11 SP - 905 EP - 914 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Fasse, Alessandro A1 - Brüggemann, Gert-Peter A1 - Abel, Dirk A1 - Albracht, Kirsten T1 - Simulative Analysis of Joint Loading During Leg Press Exercise for Control Applications T2 - IFAC-PapersOnLine Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.ifacol.2015.10.179 N1 - IFAC-PapersOnLine 48-20; Conference Paper Archive VL - 48 IS - 20 SP - 435 EP - 440 ER - TY - CHAP A1 - Kolditz, Melanie A1 - Albracht, Kirsten A1 - Fasse, Alessandro A1 - Albin, Thivaharan A1 - Brüggemann, Gert-Peter A1 - Abel, Dirk T1 - Evaluation of an industrial robot as a leg press training device T2 - XV International Symposium on Computer Simulation in Biomechanics July 9th – 11th 2015, Edinburgh, UK Y1 - 2015 SP - 41 EP - 42 ER - TY - CHAP A1 - Koplin, Tobias J. A1 - Siemons, Maike A1 - Océn-Valéntin, César A1 - Sanders, Daniel A1 - Simon, Ulrich T1 - Workflow for high throughput screening of gas sensing materials N2 - The workflow of a high throughput screening setup for the rapid identification of new and improved sensor materials is presented. The polyol method was applied to prepare nanoparticular metal oxides as base materials, which were functionalised by surface doping. Using multi-electrode substrates and high throughput impedance spectroscopy (HT-IS) a wide range of materials could be screened in a short time. Applying HT-IS in search of new selective gas sensing materials a NO2-tolerant NO sensing material with reduced sensitivities towards other test gases was identified based on iridium doped zinc oxide. Analogous behaviour was observed for iridium doped indium oxide. KW - Biosensor KW - High throughput experimentation KW - gas sensor KW - metal oxide KW - doping KW - impedance spectroscopy KW - nitrogen oxides Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1407 ER - TY - JOUR A1 - Kopp, Alexander A1 - Schmeets, Ralf A1 - Gosau, Martin A1 - Friedrich, Reinhard E. A1 - Fuest, Sandra A1 - Behbahani, Mehdi A1 - Barbeck, Mike A1 - Rutkowski, Rico A1 - Burg, Simon A1 - Kluwe, Lan A1 - Henningsen, Anders T1 - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application JF - In Vivo Y1 - 2019 U6 - http://dx.doi.org/10.21873/invivo.11536 SN - 1791-7549 VL - 33 IS - 3 SP - 757 EP - 762 ER - TY - JOUR A1 - Kopp, Alexander A1 - Schunck, Laura A1 - Gosau, Martin A1 - Smeets, Ralf A1 - Burg, Simon A1 - Fuest, Sandra A1 - Kröger, Nadja A1 - Zinser, Max A1 - Krohn, Sebastian A1 - Behbahani, Mehdi A1 - Köpf, Marius A1 - Lauts, Lisa A1 - Rutkowski, Rico T1 - Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes JF - International Journal of Molecular Sciences N2 - In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes. Y1 - 2020 U6 - http://dx.doi.org/10.3390/ijms21186704 SN - 1422-0067 N1 - Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine VL - 21 IS - 18 art. no. 6704 PB - MDPI CY - Basel ER - TY - THES A1 - Kotliar, Konstantin T1 - Pathophysiologische Beurteilung und hämodynamische Analyse von mikrostrukturellen Veränderungen des retinalen Gefäßlängsschnittsprofils Y1 - 2012 N1 - Moskau, Habil.-Schr. ,Russ. Univ., Med. Fakultät, 2012. Originaltitel in Russisch. ER - TY - THES A1 - Kotliar, Konstantin T1 - Functional in-vivo assessment and biofluidmechanical analysis of age-related and pathological microstructural changes in retinal vessels [Elektronische Ressource] Y1 - 2008 N1 - München, Techn. Univ., Diss., 2008 PB - - ER - TY - THES A1 - Kotliar, Konstantin T1 - Razrabotka i analiz matematicheskih modelei nezavisimogo i svyazannogo funkcionirovaniya drenazhnoi i akkomodacionnoi regulyatornyh sistem chelovecheskogo glaza T2 - Mathematische Modelle der interaktiven und unabhängigen Funktion von Drainage- und Akkommodations-Regelungssystemen des menschlichen Auges Y1 - 1998 N1 - St.-Petersburg, Russland, Univ., Diss., 1998 [Lehrstuhl für Theoretische Mechanik der Staatlichen Polytechnischen Universität St.-Petersburg] Originaltitel: Razrabotka i analiz matematicheskih modelei nezavisimogo i svyazannogo funkcionirovaniya drenazhnoi i akkomodacionnoi regulyatornyh sistem chelovecheskogo glaza. 328 S. PB - - ER - TY - THES A1 - Kotliar, Konstantin T1 - Dynamische retinale Gefäßanalyse für die Diagnostik und Früherkennung von System- und Augenerkrankungen vaskulärer Genese Y1 - 2013 N1 - München, Techn. Univ., Habil.-Schrift, 2013 ER - TY - CHAP A1 - Kotliar, Konstantin ED - Pallikaris, I. ED - Tsilimbaris, M. K. ED - Dastiridou, A. I. T1 - Ocular rigidity: clinical approach T2 - Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye N2 - The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications. KW - Coefficient of ocular rigidity KW - Eyeball KW - Corneo-scleral shell KW - Pressure-volume relationship KW - Differential tonometry Y1 - 2021 SN - 978-3-030-64422-2 U6 - http://dx.doi.org/10.1007/978-3-030-64422-2_2 SP - 15 EP - 43 PB - Springer CY - Cham ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Bauer, S. M. A1 - Zamuraev, L. A. T1 - Model of the transversely isotropic spherical layer for estimation of intraocular pressure changes after intravitreal injections / Bauer, S. M. ; Zamuraev, L. A. ; Kotliar, K. E. JF - Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2 Y1 - 2006 SN - 1812-5123 SP - 41 EP - 47 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Baumann, Marcus A1 - Vilser, Walthard A1 - Lanzl, Ines M. T1 - Pulse wave velocity in retinal arteries of healthy volunteers JF - British Journal of Ophthalmology (eBJO) Y1 - 2011 SN - 1468-2079 VL - 95 IS - 11 SP - 675 EP - 679 PB - BMJ Publ. Group CY - London ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Drozdova, G. A. A1 - Shamshinova, A. M. T1 - Ocular hemodinamics and contemporary methods of its assessment.
 Part I. Ocular blood circulation and its quantitative estimation JF - National journal Glaucoma Y1 - 2006 SN - 2078-4104 VL - Vol. 5 IS - No. 3 SP - 62 EP - 73 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Drozdova, G. A. A1 - Shamshinova, A. M. T1 - Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 2. Static and dynamic assessment of retinal vessel reaction to stimuli JF - National Journal Glaucoma Y1 - 2007 SN - 2078-4104 VL - Vol. 6 IS - No. 2 SP - 64 EP - 71 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Drozdova, G. A. A1 - Shamshinova, A. M. T1 - Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 1. Assessment of blood cell velocities and flow rates in intraocular vessels and vascular beds JF - Journal of Glaucoma Y1 - 2007 SN - 2078-4104 VL - Vol. 6 IS - 1 SP - 61 EP - 68 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Drozdova, G. A. A1 - Shamshinova, A. M. T1 - Ocular hemodinamics and contemporary methods of its assessment. Part II. Invasive methods of assessment of ocular blood flow JF - National Journal Glaucoma Y1 - 2006 SN - 2078-4104 VL - Vol. 5 IS - No. 4 SP - 37 EP - 49 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Hanssen, Henner A1 - Eberhardt, Karla A1 - Vilser, Walthard A1 - Schmaderer, Christoph A1 - Halle, Martin A1 - Heemann, Uwe A1 - Baumann, M. T1 - Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects JF - Microcirculation Y1 - 2013 SN - 1549-8719 N1 - Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) PB - Wiley CY - Malden ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Hauser, Christine A1 - Ortner, Marion A1 - Muggenthaler, Claudia A1 - Diehl-Schmid, Janine A1 - Angermann, Susanne A1 - Hapfelmeier, Alexander A1 - Schmaderer, Christoph A1 - Grimmer, Timo T1 - Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease JF - Scientific Reports Y1 - 2017 U6 - http://dx.doi.org/10.1038/s41598-017-13349-5 SN - 2045-2322 N1 - Article 12906 VL - 7 IS - 1 SP - 1 EP - 11 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Kharoubi, A. A1 - Schmidt-Trucksäß, A. A1 - Halle, M. A1 - Lanzl, I. T1 - Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons? JF - Acta Ophthalmologica Y1 - 2009 SN - 1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print) VL - Vol. 87 IS - Suppl. S244 SP - 0 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Koshitz, I. N. A1 - Svetlova, O. V. A1 - Zaseeva, M. V. T1 - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part I Initial theoretical presuppositions, hypotheses and facts / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotli JF - Glaukoma (2006) Y1 - 2006 N1 - Original in Russisch SP - 35 EP - 53 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Koshitz, I. N. A1 - Svetlowa, O. V. A1 - Makarov, F. N. T1 - Biomechanical analysis of traditional and contemporary conceptions on pathogenesis of the primary open angle glaucoma / Koshitz, I. N. ; Svetlova, O. V. ; Kotliar, K. E. ; Makarov, F. N. ; Smolnikov, B. A. JF - Glaukoma (2005) Y1 - 2005 N1 - Original in Russisch SP - 41 EP - 63 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Koshitz, I. N. A1 - Svetlowa, O. V. A1 - Zaseeva, M. V. T1 - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar JF - Glaukoma (2006) Y1 - 2006 N1 - Original in Russisch SP - 51 EP - 70 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Kozlova, Tatiana V. A1 - Lanzl, Ines M. T1 - Postoperative aqueous outflow in the human eye after glaucoma filtration surgery: biofluidmechanical considerations JF - Biomedizinische Technik = Biomedical Engineering Y1 - 2009 SN - 1862-278X VL - 54 IS - 1 SP - 14 EP - 22 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, I. M. T1 - Biomechanical modeling of the aqueous humor outflow after non-penetrating glaucoma filtration surgery in the human eye JF - Acta of bioengineering and biomechanics Y1 - 2002 SN - 1509-409X VL - Vol. 4 IS - Suppl. 1 SP - 728 EP - 729 ER -