TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors T1 - Markierungsfreie Detektion doppelsträngiger DNA Moleküle mit Hilfe von Polyelektrolyt-modifizierten kapazitiven Feldeffekt-Sensoren JF - tm - Technisches Messen N2 - In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA. Y1 - 2017 U6 - http://dx.doi.org/10.1515/teme-2017-0015 VL - 84 IS - 10 SP - 628 EP - 634 PB - De Gruyter CY - Oldenbourg ER - TY - CHAP A1 - Bung, Daniel B. A1 - Valero, Daniel T1 - FlowCV - An open-source toolbox for computer vision applications in turbulent flows T2 - Proceedings of the 37th IAHR World Congress August 13 – 18, 2017, Kuala Lumpur, Malaysia Y1 - 2017 SN - 2521-716X SP - 5356 EP - 5365 ER - TY - JOUR A1 - Butenweg, Christoph A1 - Rosin, Julia A1 - Holler, Stefan T1 - Analysis of cylindrical granular material silos under seismic excitation JF - Buildings N2 - Silos generally work as storage structures between supply and demand for various goods, and their structural safety has long been of interest to the civil engineering profession. This is especially true for dynamically loaded silos, e.g., in case of seismic excitation. Particularly thin-walled cylindrical silos are highly vulnerable to seismic induced pressures, which can cause critical buckling phenomena of the silo shell. The analysis of silos can be carried out in two different ways. In the first, the seismic loading is modeled through statically equivalent loads acting on the shell. Alternatively, a time history analysis might be carried out, in which nonlinear phenomena due to the filling as well as the interaction between the shell and the granular material are taken into account. The paper presents a comparison of these approaches. The model used for the nonlinear time history analysis considers the granular material by means of the intergranular strain approach for hypoplasticity theory. The interaction effects between the granular material and the shell is represented by contact elements. Additionally, soil–structure interaction effects are taken into account. KW - granular silo KW - earthquake engineering KW - hypoplasticity KW - nonlinear transient analyses Y1 - 2017 U6 - http://dx.doi.org/10.3390/buildings7030061 SN - 2075-5309 VL - 7 IS - 3 SP - 1 EP - 12 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bäcker, Matthias A1 - Koch, Claudia A1 - Eiben, Sabine A1 - Geiger, Fania A1 - Eber, Fabian A1 - Gliemann, Hartmut A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors JF - Sensors and Actuators B: Chemical N2 - The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips. Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.snb.2016.07.096 SN - 0925-4005 VL - 238 SP - 716 EP - 722 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Carzana, Livio A1 - Dachwald, Bernd A1 - Noomen, Ron T1 - Model and trajectory optimization for an ideal laser-enhanced solar sail T2 - 68th International Astronautical Congress N2 - A laser-enhanced solar sail is a solar sail that is not solely propelled by solar radiation but additionally by a laser beam that illuminates the sail. This way, the propulsive acceleration of the sail results from the combined action of the solar and the laser radiation pressure onto the sail. The potential source of the laser beam is a laser satellite that coverts solar power (in the inner solar system) or nuclear power (in the outer solar system) into laser power. Such a laser satellite (or many of them) can orbit anywhere in the solar system and its optimal orbit (or their optimal orbits) for a given mission is a subject for future research. This contribution provides the model for an ideal laser-enhanced solar sail and investigates how a laser can enhance the thrusting capability of such a sail. The term ”ideal” means that the solar sail is assumed to be perfectly reflecting and that the laser beam is assumed to have a constant areal power density over the whole sail area. Since a laser beam has a limited divergence, it can provide radiation pressure at much larger solar distances and increase the radiation pressure force into the desired direction. Therefore, laser-enhanced solar sails may make missions feasible, that would otherwise have prohibitively long flight times, e.g. rendezvous missions in the outer solar system. This contribution will also analyze exemplary mission scenarios and present optimial trajectories without laying too much emphasis on the design and operations of the laser satellites. If the mission studies conclude that laser-enhanced solar sails would have advantages with respect to ”traditional” solar sails, a detailed study of the laser satellites and the whole system architecture would be the second next step Y1 - 2017 N1 - 68th International Astronautical Congress: Unlocking Imagination, Fostering Innovation and Strengthening Security, IAC 2017, 2017-09-25 → 2017-09-29, Adelaide, Australia ER - TY - JOUR A1 - Chen, Chao A1 - Jost, Peter A1 - Volker, Hanno A1 - Kaminski, Marvin A1 - Wirtssohn, Matti R. A1 - Engelmann, Ulrich M. A1 - Krüger, K. A1 - Schlich, Franziska F. A1 - Schlockermann, Carl A1 - Lobo, Ricardo P.S.M. A1 - Wuttig, Matthias T1 - Dielectric properties of amorphous phase-change materials JF - Physical Review B Y1 - 2017 U6 - http://dx.doi.org/10.1103/PhysRevB.95.094111 SN - 2469-9950 VL - 95 IS - 9 SP - Article number 094111 ER - TY - CHAP A1 - Czarnecki, Christian A1 - Dietze, Christian ED - Maedche, Alexander ED - vom Brocke, Jan ED - Hevner, Alan T1 - Domain-Specific reference modeling in the telecommunications industry T2 - DESRIST 2017: Designing the Digital Transformation N2 - The telecommunications industry is currently going through a major transformation. In this context, the enhanced Telecom Operations Map (eTOM) is a domain-specific process reference model that is offered by the industry organization TM Forum. In practice, eTOM is well accepted and confirmed as de facto standard. It provides process definitions and process flows on different levels of detail. This article discusses the reference modeling of eTOM, i.e., the design, the resulting artifact, and its evaluation based on three project cases. The application of eTOM in three projects illustrates the design approach and concrete models on strategic and operational levels. The article follows the Design Science Research (DSR) paradigm. It contributes with concrete design artifacts to the transformational needs of the telecommunications industry and offers lessons-learned from a general DSR perspective. KW - enhanced Telecom Operations Map (eTOM) KW - Process reference model KW - Process design KW - Map (eTOM) Process reference model Process design Telecommunications industry Y1 - 2017 SN - 978-3-319-59144-5 SN - 978-3-319-59143-8 U6 - http://dx.doi.org/10.1007/978-3-319-59144-5_19 N1 - Designing the Digital Transformation 12th International Conference, DESRIST 2017, Karlsruhe, Germany, May 30 - June 1, 2017. SP - 313 EP - 329 PB - Springer CY - Cham ER - TY - BOOK A1 - Czarnecki, Christian A1 - Dietze, Christian T1 - Reference architecture for the telecommunications industry: Transformation of strategy, organization, processes, data, and applications N2 - This book reflects the tremendous changes in the telecommunications industry in the course of the past few decades – shorter innovation cycles, stiffer competition and new communication products. It analyzes the transformation of processes, applications and network technologies that are now expected to take place under enormous time pressure. The International Telecommunication Union (ITU) and the TM Forum have provided reference solutions that are broadly recognized and used throughout the value chain of the telecommunications industry, and which can be considered the de facto standard. The book describes how these reference solutions can be used in a practical context: it presents the latest insights into their development, highlights lessons learned from numerous international projects and combines them with well-founded research results in enterprise architecture management and reference modeling. The complete architectural transformation is explained, from the planning and set-up stage to the implementation. Featuring a wealth of examples and illustrations, the book offers a valuable resource for telecommunication professionals, enterprise architects and project managers alike. KW - Enterprise architecture KW - Enterprise transformation KW - Reference modelling KW - TM Forum KW - Telecommunication Y1 - 2017 SN - 978-3-319-46755-9 (Print) SN - 978-3-319-83578-5 (Print) SN - 978-3-319-46757-3 (PDF) U6 - http://dx.doi.org/10.1007/978-3-319-46757-3 PB - Springer CY - Cham ER - TY - CHAP A1 - Dachwald, Bernd ED - Knopf, George K. ED - Otani, Yukitoshi T1 - Light propulsion systems for spacecraft T2 - Optical nano and micro actuator technology Y1 - 2017 SN - 9781315217628 (eBook) SP - 577 EP - 598 PB - CRC Press CY - Boca Raton ER - TY - CHAP A1 - Dachwald, Bernd T1 - Radiation pressure force model for an ideal laser-enhanced solar sail T2 - 4th International Symposium on Solar Sailing N2 - The concept of a laser-enhanced solar sail is introduced and the radiation pressure force model for an ideal laser-enhanced solar sail is derived. A laser-enhanced solar sail is a “traditional” solar sail that is, however, not solely propelled by solar radiation, but additionally by a laser beam that illuminates the sail. The additional laser radiation pressure increases the sail's propulsive force and can give, depending on the location of the laser source, more control authority over the direction of the solar sail’s propulsive force vector. This way, laser-enhanced solar sails may augment already existing solar sail mission concepts and make novel mission concepts feasible. Y1 - 2017 N1 - 4th International Symposium on Solar Sailing 17-20 January 2017, Kyōto, Japan SP - 1 EP - 5 ER - TY - JOUR A1 - Damm, Marc André A1 - Sauerborn, Markus A1 - Fend, Thomas A1 - Herrmann, Ulf T1 - Optimisation of a urea selective catalytic reduction system with a coated ceramic mixing element JF - Journal of ceramic science and technology Y1 - 2017 SN - 2190-9385 (Print) U6 - http://dx.doi.org/10.4416/JCST2016-00056 SN - 2190-9385 (Online) VL - 8 IS - 1 SP - 19 EP - 24 PB - Göller CY - Baden-Baden ER - TY - JOUR A1 - Dantism, Shahriar A1 - Takenaga, Shoko A1 - Wagner, Torsten A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Differential imaging of the metabolism of bacteria and eukaryotic cells based on light-addressable potentiometric sensors JF - Electrochimica Acta N2 - A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric sensor with an electrolyte/insulator/semiconductor (EIS) structure, which is able to monitor analyte concentrations of (bio-)chemical species in aqueous solutions in a spatially resolved way. Therefore, it is also an appropriate tool to record 2D-chemical images of concentration variations on the sensor surface. In the present work, two differential, LAPS-based measurement principles are introduced to determine the metabolic activity of Escherichia coli (E. coli) K12 and Chinese hamster ovary (CHO) cells as test microorganisms. Hereby, we focus on i) the determination of the extracellular acidification rate (ΔpH/min) after adding glucose solutions to the cell suspensions; and ii) recording the amplitude increase of the photocurrent (Iph) related to the produced acids from E. coli K12 bacteria and CHO cells on the sensor surface by 2D-chemical imaging. For this purpose, 3D-printed multi-chamber structures were developed and mounted on the planar sensor-chip surface to define four independent compartments, enabling differential measurements with varying cell concentrations. The differential concept allows eliminating unwanted drift effects and, with the four-chamber structures, measurements on the different cell concentrations were performed simultaneously, thus reducing also the overall measuring time. Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.electacta.2017.05.196 SN - 0013-4686 VL - 246 SP - 234 EP - 241 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - de Honde, Lukas A1 - Porst, Dariusz A1 - Digel, Ilya ED - Fischerauer, Alice T1 - A randomized, observational thermographic study of the neck region before and after a physiotherapeutic intervention T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 122 EP - 123 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Demmer, Julius K. A1 - Chowdhury, Nilanjan Pal A1 - Selmer, Thorsten A1 - Ermler, Ulrich A1 - Buckel, Wolfgang T1 - The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile JF - Nature Communications Y1 - 2017 U6 - http://dx.doi.org/10.1038/s41467-017-01746-3 SN - 2041-1723 N1 - Article number 1577 VL - 8 IS - 1 SP - 1 EP - 10 ER - TY - JOUR A1 - Dikta, Gerhard T1 - Semi-parametric random censorship models JF - From Statistics to Mathematical Finance : Festschrift in Honour of Winfried Stute Y1 - 2017 SN - 978-3-319-50986-0 U6 - http://dx.doi.org/10.1007/978-3-319-50986-0_3 SP - 43 EP - 56 PB - Springer CY - Berlin ER - TY - CHAP A1 - Dowidat, Linda A1 - König, Johannes Alexander A1 - Wolf, Martin T1 - The motivational competence developing game framework T2 - Mensch und Computer 2017 - Tagungsband N2 - Competence Developing Games (CDGs) are a new concept of how to think about games with serious intentions. In order to emphasize on this topic, a new framework has been developed. It basically relies on learning and motivation theories. This ‘motivational Competence Developing Game Framework’ demonstrates how it is possible to use these theories in a CDG development process. The theoretical derivation and use of the framework is explained in this paper. KW - Competence Developing Games KW - Serious Games KW - Gamification KW - motivation theories KW - learning theories Y1 - 2017 U6 - http://dx.doi.org/10.18420/muc2017-mci-0130 SP - 15 EP - 26 PB - Gesellschaft für Informatik e.V. CY - Regensburg ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred T1 - Physical response of hyperelastic models for composite materials and soft tissues T2 - Advances in Composite Material Y1 - 2017 SN - 978-1-61896-300-0 (Hardcover), 978-1-61896-299-7 (Paperback) N1 - Chapter 5 PB - Scientific Research Publishing CY - Wuhan ER - TY - CHAP A1 - Endress, Tim A1 - Bragard, Michael T1 - Recording of efficiency-maps of low-power electric drive systems using a flexible matlab-based test bench T2 - 2017 IEEE 58th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) N2 - This paper introduces a hardware setup to measure efficiency maps of low-power electric motors and their associated inverters. Here, the power of the device under test (DUT) ranges from some Watts to a few hundred Watts. The torque and speed of the DUT are measured independent of voltage and current in multiple load points. A Matlab-based software approach in combination with an open Texas-Instruments (TI) hardware setup ensures flexibility. Exemplarily, the efficiency field of a Permanent Magnet Synchronous Machine (PMSM) is measured to proof the concept. Brushless-DC (BLDC) motors can be tested as well. The nomenclature in this paper is based on the new European standard DIN EN 50598. Special attention is paid to the calculation of the measurement error. Y1 - 2017 SN - 978-1-5386-3846-0 U6 - http://dx.doi.org/10.1109/RTUCON.2017.8124775 PB - IEEE CY - New York ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Buhl, Eva Miriam A1 - Baumann, Martin A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia JF - Current Directions in Biomedical Engineering Y1 - 2017 U6 - http://dx.doi.org/10.1515/cdbme-2017-0096 SN - 2364-5504 VL - 3 IS - 2 SP - 457 EP - 460 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Fiedler, Thomas M. A1 - Ladd, Mark E. A1 - Bitz, Andreas T1 - SAR Simulations & Safety JF - NeuroImage Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.neuroimage.2017.03.035 SN - 1053-8119 IS - Epub ahead of print PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Fiedler, Thomas M. A1 - Ladd, Mark E. A1 - Bitz, Andreas T1 - RF safety assessment of a bilateral four-channel transmit/receive 7 Tesla breast coil: SAR versus temperature limits JF - Medical Physics Y1 - 2017 U6 - http://dx.doi.org/10.1002/mp.12034 N1 - This article is corrected by: Errata: Erratum: “RF safety assessment of a bilateral four-channel transmit/receive 7 Tesla breast coil: SAR versus tissue temperature limits” [Med. Phys. 44(1), 143–157 (2017)] Volume 44, Issue 2, 772 VL - 44 IS - 1 SP - 143 EP - 157 ER - TY - CHAP A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - The Impact of Electric Propulsion on the Performance of VTOL UAVs T2 - Deutscher Luft- und Raumfahrtkongress 2017, DLRK , München Y1 - 2017 ER - TY - CHAP A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - A Review of Configuration Design for Distributed Propulsion Transitioning VTOL Aircraft T2 - Asia-Pacific International Symposium on Aerospace Technology 2017, APISAT 2017, Seoul, Korea Y1 - 2017 ER - TY - CHAP A1 - Funke, Harald A1 - Beckmann, Nils A1 - Abanteriba, Sylvester T1 - A comparison of complex chemistry mechanisms for hydrogen methane blends based on the Sandia / Sydney Bluff-Body Flame HM1 T2 - Proceedings of the Eleventh Asia‐Pacific Conference on Combustion (ASPACC 2017), New South Wales, Australia, 10-14 December 2017 Y1 - 2017 SN - 978-1-5108-5646-2 SP - 262 EP - 265 ER - TY - CHAP A1 - Funke, Harald A1 - Beckmann, Nils A1 - Keinz, Jan A1 - Abanteriba, Sylvester T1 - Numerical and Experimental Evaluation of a Dual-Fuel Dry-Low-NOx Micromix Combustor for Industrial Gas Turbine Applications T2 - Proceedings of the ASME Turbo Expo 2017: Turbomachinery Technical Conference and Exposition. Volume 4B: Combustion, Fuels and Emissions. Charlotte, North Carolina, USA. June 26–30, 2017 N2 - The Dry-Low-NOx (DLN) Micromix combustion technology has been developed originally as a low emission alternative for industrial gas turbine combustors fueled with hydrogen. Currently the ongoing research process targets flexible fuel operation with hydrogen and syngas fuel. The non-premixed combustion process features jet-in-crossflow-mixing of fuel and oxidizer and combustion through multiple miniaturized flames. The miniaturization of the flames leads to a significant reduction of NOx emissions due to the very short residence time of reactants in the flame. The paper presents the results of a numerical and experimental combustor test campaign. It is conducted as part of an integration study for a dual-fuel (H2 and H2/CO 90/10 Vol.%) Micromix combustion chamber prototype for application under full scale, pressurized gas turbine conditions in the auxiliary power unit Honeywell Garrett GTCP 36-300. In the presented experimental studies, the integration-optimized dual-fuel Micromix combustor geometry is tested at atmospheric pressure over a range of gas turbine operating conditions with hydrogen and syngas fuel. The experimental investigations are supported by numerical combustion and flow simulations. For validation, the results of experimental exhaust gas analyses are applied. Despite the significantly differing fuel characteristics between pure hydrogen and hydrogen-rich syngas the evaluated dual-fuel Micromix prototype shows a significant low NOx performance and high combustion efficiency. The combustor features an increased energy density that benefits manufacturing complexity and costs. Y1 - 2017 SN - 978-0-7918-5085-5 U6 - http://dx.doi.org/10.1115/GT2017-64795 N1 - Paper No. GT2017-64795, V04BT04A045 PB - ASME CY - New York ER - TY - CHAP A1 - Funke, Harald A1 - Keinz, Jan A1 - Hendrick, P. T1 - Experimental Evaluation of the Pollutant and Noise Emissions of the GTCP 36-300 Gas Turbine Operated with Kerosene and a Low NOX Micromix Hydrogen Combustor T2 - 7th European Conference for Aeronautics and Space Sciences, EUCASS 2017 Y1 - 2017 U6 - http://dx.doi.org/10.13009/EUCASS2017-125 ER - TY - CHAP A1 - Galdi, Chiara A1 - Hartung, Frank A1 - Dugelay, Jean-Luc T1 - Videos versus still images: Asymmetric sensor pattern noise comparison on mobile phones T2 - Electronic Imaging N2 - Nowadays, the most employed devices for recoding videos or capturing images are undoubtedly the smartphones. Our work investigates the application of source camera identification on mobile phones. We present a dataset entirely collected by mobile phones. The dataset contains both still images and videos collected by 67 different smartphones. Part of the images consists in photos of uniform backgrounds, especially collected for the computation of the RSPN. Identifying the source camera given a video is particularly challenging due to the strong video compression. The experiments reported in this paper, show the large variation in performance when testing an highly accurate technique on still images and videos. KW - Image Forensics KW - Mobile Phones KW - Image Database Y1 - 2017 U6 - http://dx.doi.org/10.2352/ISSN.2470-1173.2017.7.MWSF-331 SN - 2470-1173 N1 - IS&T International Symposium on Electronic Imaging 2017 Media Watermarking, Security, and Forensics 2017 SP - 100 EP - 103 PB - Society for Imaging Science and Technology CY - Springfield, Virginia ER - TY - JOUR A1 - Gamella, Maria A1 - Zakharchenko, Andrey A1 - Guz, Nataliia A1 - Masi, Madeline A1 - Minko, Sergiy A1 - Kolpashchikov, Dmitry M. A1 - Iken, Heiko A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Katz, Evgeny T1 - DNA computing system activated by electrochemically triggered DNA realease from a polymer-brush-modified electrode array JF - Electroanalysis N2 - An array of four independently wired indium tin oxide (ITO) electrodes was used for electrochemically stimulated DNA release and activation of DNA-based Identity, AND and XOR logic gates. Single-stranded DNA molecules were loaded on the mixed poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA)/poly(methacrylic acid) (PMAA) brush covalently attached to the ITO electrodes. The DNA deposition was performed at pH 5.0 when the polymer brush is positively charged due to protonation of tertiary amino groups in PDMAEMA, thus resulting in electrostatic attraction of the negatively charged DNA. By applying electrolysis at −1.0 V(vs. Ag/AgCl reference) electrochemical oxygen reduction resulted in the consumption of hydrogen ions and local pH increase near the electrode surface. The process resulted in recharging the polymer brush to the negative state due to dissociation of carboxylic groups of PMAA, thus repulsing the negatively charged DNA and releasing it from the electrode surface. The DNA release was performed in various combinations from different electrodes in the array assembly. The released DNA operated as input signals for activation of the Boolean logic gates. The developed system represents a step forward in DNA computing, combining for the first time DNA chemical processes with electronic input signals. Y1 - 2017 U6 - http://dx.doi.org/10.1002/elan.201600389 SN - 1521-4109 VL - 29 IS - 2 SP - 398 EP - 408 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Garibaldi, F. A1 - Beging, Stefan A1 - Canese, R. A1 - Carpinelli, G. A1 - Clinthorne, N. A1 - Colilli, S. A1 - Cosentino, L. A1 - Finocchiaro, P. A1 - Giuliani, F. A1 - Gricia, M. A1 - Lucentini, M. A1 - Majewski, S. A1 - Monno, E. A1 - Musico, P. A1 - Santavenere, F. A1 - Tödter, J. A1 - Wegener, Hans-Peter A1 - Ziemons, Karl T1 - A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer JF - European Physical Journal Plus Y1 - 2017 U6 - http://dx.doi.org/10.1140/epjp/i2017-11662-x SN - 2190-5444 VL - 132 IS - 9 PB - Springer CY - Berlin ER - TY - JOUR A1 - Giresini, Linda A1 - Sassu, Mauro A1 - Butenweg, Christoph A1 - Alecci, Valerio A1 - De Stefano, Mario T1 - Vault macro-element with equivalent trusses in global seismic analyses JF - Earthquakes and Structures N2 - This paper proposes a quick and simplified method to describe masonry vaults in global seismic analyses of buildings. An equivalent macro-element constituted by a set of six trusses, two for each transverse, longitudinal and diagonal direction, is introduced. The equivalent trusses, whose stiffness is calculated by fully modeled vaults of different geometry, mechanical properties and boundary conditions, simulate the vault in both global analysis and local analysis, such as kinematic or rocking approaches. A parametric study was carried out to investigate the influence of geometrical characteristics and mechanical features on the equivalent stiffness values. The method was numerically validated by performing modal and transient analysis on a three naves-church in the elastic range. Vibration modes and displacement time-histories were compared showing satisfying agreement between the complete and the simplified models. This procedure is particularly useful in engineering practice because it allows to assess, in a simplified way, the effectiveness of strengthening interventions for reducing horizontal relative displacements between vault supports. KW - vault KW - macro-element KW - equivalent stiffness KW - truss KW - churches Y1 - 2017 U6 - http://dx.doi.org/10.12989/eas.2017.12.4.409 SN - 2092-7614 (Print) SN - 2092-7622 (Online) VL - 12 IS - 4 SP - 409 EP - 423 PB - Techno-Press CY - Taejŏn ER - TY - CHAP A1 - Granat, Andreas A1 - Höfken, Hans-Wilhelm A1 - Schuba, Marko T1 - Intrusion Detection of the ICS Protocol EtherCAT N2 - Control mechanisms like Industrial Controls Systems (ICS) and its subgroup SCADA (Supervisory Control and Data Acquisition) are a prerequisite to automate industrial processes. While protection of ICS on process management level is relatively straightforward – well known office IT security mechanisms can be used – protection on field bus level is harder to achieve as there are real-time and production requirements like 24x7 to consider. One option to improve security on field bus level is to introduce controls that help to detect and to react on attacks. This paper introduces an initial set of intrusion detection mechanisms for the field bus protocol EtherCAT. To this end existing Ethernet attack vectors including packet injection and man-in-the-middle attacks are tested in an EtherCAT environment, where they could interrupt the EtherCAT network and may even cause physical damage. Based on the signatures of such attacks, a preprocessor and new rule options are defined for the open source intrusion detection system Snort demonstrating the general feasibility of intrusion detection on field bus level. Y1 - 2017 N1 - International Conference on Computer, Network Security and Communication Engineering (CNSCE 2017), March 26-27, 2017, Bangkok, Thailand SP - 1 EP - 5 ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Biele, Jens A1 - Dachwald, Bernd A1 - Grimm, Christian D. A1 - Lange, Caroline A1 - Ulamec, Stephan A1 - Ziach, Christian A1 - Spröwitz, Tom A1 - Ruffer, Michael A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Toth, Norbert A1 - Mimasu, Yuya A1 - Rittweger, Andreas A1 - Bibring, Jean-Pierre A1 - Braukhane, Andy A1 - Boden, Ralf Christian A1 - Dumont, Etienne A1 - Jahnke, Stephan Siegfried A1 - Jetzschmann, Michael A1 - Krüger, Hans A1 - Lange, Michael A1 - Gomez, Antonio Martelo A1 - Massonett, Didier A1 - Okada, Tatsuaki A1 - Sagliano, Marco A1 - Sasaki, Kaname A1 - Schröder, Silvio A1 - Sippel, Martin A1 - Skoczylas, Thomas A1 - Wejmo, Elisabet T1 - Small landers and separable sub-spacecraft for near-term solar sails T2 - The Fourth International Symposium on Solar Sailing 2017 N2 - Following the successful PHILAE landing with ESA's ROSETTA probe and the launch of the MINERVA rovers and the Mobile Asteroid Surface Scout, MASCOT, aboard the JAXA space probe, HAYABUSA2, to asteroid (162173) Ryugu, small landers have found increasing interest. Integrated at the instrument level in their mothership they support small solar system body studies. With efficient capabilities, resource-friendly design and inherent robustness they are an attractive exploration mission element. We discuss advantages and constraints of small sub-spacecraft, focusing on emerging areas of activity such as asteroid diversity studies, planetary defence, and asteroid mining, on the background of our projects PHILAE, MASCOT, MASCOT2, the JAXA-DLR Solar Power Sail Lander Design Study, and others. The GOSSAMER-1 solar sail deployment concept also involves independent separable sub-spacecraft operating synchronized to deploy the sail. Small spacecraft require big changes in the way we do things and occasionally a little more effort than would be anticipated based on a traditional large spacecraft approach. In a Constraints-Driven Engineering environment we apply Concurrent Design and Engineering (CD/CE), Concurrent Assembly, Integration and Verification (CAIV) and Model-Based Systems Engineering (MBSE). Near-term solar sails will likely be small spacecraft which we expect to harmonize well with nano-scale separable instrument payload packages. KW - Small Solar System Body Lander KW - Small Spacecraft KW - PHILAE KW - MASCOT KW - Solar Power Sail Y1 - 2017 N1 - The Fourth International Symposium on Solar Sailing 2017, 17-20 January 2017. Kyoto Research Park, Kyoto, Japan SP - 1 EP - 10 ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Boden, Ralf A1 - Ceriotti, Matteo A1 - Dachwald, Bernd A1 - Dumont, Etienne A1 - Grimm, Christian D. A1 - Lange, Caroline A1 - Lichtenheldt, Roy A1 - Pelivan, Ivanka A1 - Peloni, Alessandro A1 - Riemann, Johannes A1 - Spröwitz, Tom A1 - Tardivel, Simon T1 - Soil to sail-asteroid landers on near-term sailcraft as an evolution of the GOSSAMER small spacecraft solar sail concept for in-situ characterization T2 - 5th IAA Planetary Defense Conference KW - multiple NEA rendezvous KW - solar sail KW - GOSSAMER-1 KW - MASCOT KW - asteroid sample return Y1 - 2017 N1 - 5th IAA Planetary Defense Conference – PDC 2017 15-19 May 2017, Tokyo, Japan ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Meß, Jan-Gerd A1 - Biele, Jens A1 - Seefeldt, Patric A1 - Dachwald, Bernd A1 - Spietz, Peter A1 - Grimm, Christian D. A1 - Spröwitz, Tom A1 - Lange, Caroline A1 - Ulamec, Stephan T1 - Small spacecraft in small solar system body applications T2 - IEEE Aerospace Conference 2017, Big Sky, Montana, USA Y1 - 2017 SN - 978-1-5090-1613-6 U6 - http://dx.doi.org/10.1109/AERO.2017.7943626 SP - 1 EP - 20 ER - TY - JOUR A1 - Hackl, M. A1 - Andermahr, J. A1 - Staat, Manfred A1 - Bremer, I. A1 - Borggrefe, J. A1 - Prescher, A. A1 - Müller, L. P. A1 - Wegmann, K. T1 - Suture button reconstruction of the central band of the interosseous membrane in Essex-Lopresti lesions: a comparative biomechanical investigation JF - The Journal of Hand Surgery (European Volume) Y1 - 2017 U6 - http://dx.doi.org/10.1177/1753193416665943 SN - 2043-6289 (Online) SN - 1753-1934 (Print) VL - 42 IS - 4 SP - 370 EP - 376 PB - Sage CY - London ER - TY - JOUR A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Kahmann, Stephanie Lucina A1 - Heinze, Nicolai A1 - Staat, Manfred A1 - Neiss, Wolfram F. A1 - Scaal, Martin A1 - Müller, Lars P. T1 - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow JF - Knee Surgery, Sports Traumatology, Arthroscopy Y1 - 2017 U6 - http://dx.doi.org/10.1007/s00167-017-4468-z SN - 1433-7347 VL - 25 IS - 7 SP - 2280 EP - 2288 PB - Springer CY - Berlin ER - TY - GEN A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Kahmann, Stephanie Lucina A1 - Heinze, Nicolai A1 - Staat, Manfred A1 - Neiss, Wolfram F. A1 - Scaal, Martin A1 - Müller, Lars P. T1 - Reply to the letter to the editor: shortening osteotomy of the proximal radius T2 - Knee Surgery, Sports Traumatology, Arthroscopy Y1 - 2017 U6 - http://dx.doi.org/10.1007/s00167-017-4666-8 VL - 25 IS - 10 SP - 3328 EP - 3329 ER - TY - CHAP A1 - Herrmann, Ulf A1 - Kearney, D. A1 - Röger, M. A1 - Prahl, C. T1 - System performance measurements T2 - The Performance of Concentrated Solar Power (CSP) Systems : Modelling, Measurement and Assessment N2 - This chapter introduces performance and acceptance testing and describes state-of-the-art tools, methods, and instruments to assess the plant performance or realize plant acceptance testing. The status of the development of standards for performance assessment is given. KW - Performance measurement KW - Acceptance tests KW - Plant efficiency Y1 - 2017 SN - 978-0-08-100448-7 U6 - http://dx.doi.org/https://doi.org/10.1016/B978-0-08-100447-0.00005-5 SP - 115 EP - 165 PB - Woodhead Publishing CY - Duxford ER - TY - JOUR A1 - Honarvarfard, Elham A1 - Gamella, Maria A1 - Channaveerappa, Devika A1 - Darie, Costel C. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Katz, Evgeny T1 - Electrochemically Stimulated Insulin Release from a Modified Graphene–functionalized Carbon Fiber Electrode JF - Electroanalysis N2 - A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9–10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of −1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species. Y1 - 2017 U6 - http://dx.doi.org/10.1002/elan.201700095 SN - 1521-4109 VL - 29 IS - 6 SP - 1543 EP - 1553 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Honarvarfard, Elham A1 - Gamella, Maria A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Katz, Evgeny T1 - An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer JF - Applied Materials Today N2 - An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte–insulator–semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications. KW - Electrolyte–insulator–semiconductor KW - Capacitive field-effect KW - CNOT KW - XOR KW - Enzyme logic gate Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.apmt.2017.08.003 SN - 2352-9407 VL - 9 SP - 266 EP - 270 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Horbach, Andreas A1 - Duong, Minh Tuan A1 - Staat, Manfred T1 - Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement JF - Journal of the mechanical behavior of biomedical materials Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.jmbbm.2017.06.012 SN - 1751-6161 VL - 74 SP - 400 EP - 410 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Höttges, Jörg T1 - QKan - Management of drainage system data with QGIS JF - Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings Y1 - 2017 VL - 17 IS - Article 13 SP - 95 EP - 100 ER - TY - CHAP A1 - Jabbari, Medisa A1 - Bhattarai, Aroj A1 - Anding, Ralf A1 - Staat, Manfred ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Biomechanical simulation of different prosthetic meshes for repairing uterine/vaginal vault prolapse T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 118 EP - 119 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Jablonski, Melanie A1 - Koch, Claudia A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier T2 - MDPI Proceeding Y1 - 2017 U6 - http://dx.doi.org/10.3390/proceedings1040505 N1 - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017 VL - 1 IS - 4 ER - TY - JOUR A1 - Jildeh, Zaid B. A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Kremers, Alexander A1 - Wagner, Torsten A1 - Wagner, Patrick H. A1 - Schöning, Michael Josef T1 - FEM-based modeling of a calorimetric gas sensor for hydrogen peroxide monitoring JF - physica status solidi a : applications and materials sciences N2 - A physically coupled finite element method (FEM) model is developed to study the response behavior of a calorimetric gas sensor. The modeled sensor serves as a monitoring device of the concentration of gaseous hydrogen peroxide (H2 O2) in a high temperature mixture stream in aseptic sterilization processes. The principle of operation of a calorimetric H2 O2 sensor is analyzed and the results of the numerical model have been validated by using previously published sensor experiments. The deviation in the results between the FEM model and experimental data are presented and discussed. Y1 - 2017 U6 - http://dx.doi.org/10.1002/pssa.201600912 SN - 1862-6319 IS - Early View PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Karnatak, Rajat A1 - Kantz, Holger A1 - Bialonski, Stephan T1 - Early warning signal for interior crises in excitable systems JF - Physical Review E Y1 - 2017 U6 - http://dx.doi.org/10.1103/PhysRevE.96.042211 SN - 2470-0053 VL - 96 IS - 4 SP - 042211 ER - TY - JOUR A1 - Katz, Evgeny A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics JF - Analytical and Bioanalytical Chemistry N2 - The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a “filter” system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s00216-016-0079-7 SN - 1618-2650 VL - 409 SP - 81 EP - 94 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kerpen, Nils B. A1 - Bung, Daniel B. A1 - Valero, Daniel A1 - Schlurmann, Torsten T1 - Energy dissipation within the wave run-up at stepped revetments JF - Journal of Ocean University of China Y1 - 2017 U6 - http://dx.doi.org/10.1007/s11802-017-3355-z SN - 1993-5021 VL - 16 IS - 4 SP - 649 EP - 654 PB - Springer CY - Berlin ER - TY - CHAP A1 - Kessler, Julia A1 - Balc, Nicolae A1 - Gebhardt, Andreas A1 - Abbas, Karim T1 - Basic research on lattice structures focused on the reliance of the cross sectional area and additional coatings T2 - The 4th International Conference on Computing and Solutions in Manufacturing Engineering 2016 – CoSME’16 Y1 - 2017 U6 - http://dx.doi.org/10.1051/matecconf/20179403008 N1 - MATEC Web Conf. Vol 94, 2017, 03008 MATEC Web of Conferences 94, 03008 (2017) ET - Vol. 94 ER - TY - JOUR A1 - Kilic, S. A. A1 - Raatschen, Hans-Jürgen A1 - Körfgen, B. A1 - Apaydin, N. M. A1 - Astaneh-Asl, A. T1 - FE Model of the Fatih Sultan Mehmet Suspension Bridge Using Thin Shell Finite Elements JF - Arabian Journal for Science and Engineering N2 - This paper presents the results of an eigenvalue analysis of the Fatih Sultan Mehmet Bridge. A high-resolution finite element model was created directly from the available design documents. All physical properties of the structural components were included in detail, so no calibration to the measured data was necessary. The deck and towers were modeled with shell elements. A nonlinear static analysis was performed before the eigenvalue calculation. The calculated natural frequencies and corresponding mode shapes showed good agreement with the available measured ambient vibration data. The calculation of the effective modal mass showed that nine modes had single contributions higher than 5 % of the total mass. They were in a frequency range up to 1.2 Hz. The comparison of the results for the torsional modes especially demonstrated the advantage of using thin shell finite elements over the beam modeling approach. KW - Suspension bridge KW - 3D nonlinear finite element model KW - Thin shell finite elements KW - Natural frequency KW - Effective modal mass Y1 - 2017 U6 - http://dx.doi.org/10.1007/s13369-016-2316-y SN - 2191-4281 VL - 42 IS - 3 SP - 1103 EP - 1116 PB - Springer Nature ER - TY - JOUR A1 - Klein, Michel A1 - Butenweg, Christoph A1 - Klinkel, Sven T1 - The Influence of Soil-Structure-Interaction on the Fatigue Analysis in the Foundation Design of Onshore Wind Turbines JF - Procedia Engineering Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.proeng.2017.09.325 SN - 1877-7058 VL - 199 SP - 3218 EP - 3223 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Hauser, Christine A1 - Ortner, Marion A1 - Muggenthaler, Claudia A1 - Diehl-Schmid, Janine A1 - Angermann, Susanne A1 - Hapfelmeier, Alexander A1 - Schmaderer, Christoph A1 - Grimmer, Timo T1 - Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease JF - Scientific Reports Y1 - 2017 U6 - http://dx.doi.org/10.1038/s41598-017-13349-5 SN - 2045-2322 N1 - Article 12906 VL - 7 IS - 1 SP - 1 EP - 11 PB - Springer Nature CY - Cham ER - TY - CHAP A1 - Kreyer, Jörg A1 - Esch, Thomas T1 - Simulation Tool for Predictive Control Strategies for an ORCSystem in Heavy Duty Vehicles T2 - European GT Conference 2017 N2 - Scientific questions - How can a non-stationary heat offering in the commercial vehicle be used to reduce fuel consumption? - Which potentials offer route and environmental information among with predicted speed and load trajectories to increase the efficiency of a ORC-System? Methods - Desktop bound holistic simulation model for a heavy duty truck incl. an ORC System - Prediction of massflows, temperatures and mixture quality (AFR) of exhaust gas Y1 - 2017 N1 - European GT Conference 2017, 9.-10. Oktober 2017, Frankfurt a.M. ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin T1 - Names of individuals T2 - European Encyclopedia of Private International Law Y1 - 2017 SN - 9781782547228 PB - Edward Elgar Publishing CY - Cheltenham, UK ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin T1 - Small Claims Regulation T2 - European Encyclopedia of Private International Law Y1 - 2017 SN - 9781782547228 PB - Edward Elgar Publishing CY - Cheltenham, UK ER - TY - CHAP A1 - Kubalski, T. A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Klinkel, S. T1 - Investigation Of The Seismic Behaviour Of Infill Masonry Using Numerical Modelling Approaches T2 - 16th World Conference on Earthquake Engineering, 16WCEE 2017 Santiago Chile, January 9th to 13th 2017 N2 - Masonry is a widely spread construction type which is used all over the world for different types of structures. Due to its simple and cheap construction, it is used as non-structural as well as structural element. In frame structures, such as reinforced concrete frames, masonry may be used as infill. While the bare frame itself is able to carry the loads when it comes to seismic events, the infilled frame is not able to warp freely due to the constrained movement. This restraint results in a complex interaction between the infill and the surrounding frame, which may lead to severe damage to the infill as well as the surrounding frame. The interaction is studied in different projects and effective approaches for the description of the behavior are still lacking. Experimental programs are usually quite expensive, while numerical models, once validated, do offer an efficient approach for the investigation of the interaction when horizontally loaded. In order to study the numerous parameters influencing the seismic load bearing behavior, numerical models may be used. Therefore, this contribution presents a numerical approach for the simulation of infill masonry in reinforced concrete frames. Both parts, the surrounding frame as well as the infill are represented by micro modelling approaches to correctly take into account the different types of failure. The adopted numerical model describes the inelastic behavior of the system, as indicated by the obtained results of the overall structural response as well as the formation of damage in the infilled wall. Comparison of the numerical and experimental results highlights the valuable contribution of numerical simulations in the study and design of infilled frames. As damage of the infill masonry may occur in-plane due to the interaction as well as out-of-plane due to the low vertical load, both directions of loading are investigated. Y1 - 2017 N1 - Paper No 3064 SP - 1 EP - 11 PB - Chilean Association on Seismology and Earthquake Engineering (ACHISINA) ER - TY - CHAP A1 - Kuhlen, Max A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Fluorescence signatures and detection limits of ubiquitous terrestrial bio-compounds T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 102 EP - 103 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Liu, Z. A1 - Schaap, K. S. A1 - Ballemans, L. A1 - de Blois, E. A1 - Rohde, M. A1 - Paulßen, Elisabeth T1 - Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system JF - Dalton Transactions Y1 - 2017 U6 - http://dx.doi.org/10.1039/C7DT01830D SN - 1477-9234 VL - 46 IS - 42 SP - 14669 EP - 14676 ER - TY - JOUR A1 - Lopes, Pedro A1 - Leandro, Jorge A1 - Carvalho, Rita F. A1 - Bung, Daniel B. T1 - Alternating skimming flow over a stepped spillway JF - Environmental Fluid Mechanics Y1 - 2017 U6 - http://dx.doi.org/10.1007/s10652-016-9484-x SN - 1573-1510 VL - 17 IS - 2 SP - 303 EP - 322 PB - Springer CY - Berlin ER - TY - CHAP A1 - Marco, Heather G. A1 - Ferrein, Alexander T1 - AGNES: The African-German Network of Excellence in Science T2 - Proceedings of the 2nd Developing World Robotics Forum, Workshop at IEEE AFRICON 2017 Y1 - 2017 SP - 1 EP - 2 ER - TY - JOUR A1 - Mayer, Jan A1 - Hentschke, Reinhard A1 - Hager, Jonathan A1 - Hojdis, Nils A1 - Karimi-Varnaneh, Hossein Ali T1 - A Nano-Mechanical Instability as Primary Contribution to Rolling Resistance JF - Scientific Reports Y1 - 2017 SN - 2045-2322 VL - 7 IS - Article number 11275 PB - Springer CY - Berlin ER - TY - JOUR A1 - Meyer, Jan A1 - Hentschke, Reinhard A1 - Hager, Jonathan A1 - Hojdis, Nils A1 - Karimi-Varzaneh, Hossein Ali T1 - Molecular Simulation of Viscous Dissipation due to Cyclic Deformation of a Silica–Silica Contact in Filled Rubber JF - Macromolecules Y1 - 2017 U6 - http://dx.doi.org/10.1021/acs.macromol.7b00947 SN - 1520-5835 VL - 50 IS - 17 SP - 6679 EP - 6689 ER - TY - JOUR A1 - Michael, Hackl A1 - Mayer, Katharina A1 - Weber, Mareike A1 - Staat, Manfred A1 - van Riet, Roger A1 - Burkhart, Klau Josef A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - Plate osteosynthesis of proximal ulna fractures : a biomechanical micromotion analysis JF - The journal of hand surgery Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.jhsa.2017.05.014 SN - 0363-5023 VL - 42 IS - 10 SP - 834.e1 EP - 834.e7 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Hayashi, Kosuke A1 - Sakamoto, Azuma A1 - Werner, Frederik A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - A high-Q resonance-mode measurement of EIS capacitive sensor by elimination of series resistance JF - Sensor and Actuators B: Chemical N2 - An EIS capacitive sensor is a semiconductor-based potentiometric sensor, which is sensitive to the ion concentration or pH value of the solution in contact with the sensing surface. To detect a small change in the ion concentration or pH, a small capacitance change must be detected. Recently, a resonance-mode measurement was proposed, in which an inductor was connected to the EIS capacitive sensor and the resonant frequency was correlated with the pH value. In this study, the Q factor of the resonant circuit was enhanced by canceling the internal resistance of the reference electrode and the internal resistance of the inductor coil with the help of a bypass capacitor and a negative impedance converter, respectively. 1% variation of the signal in the developed system corresponded to a pH change of 3.93 mpH, which was about 1/12 of the conventional method, suggesting a better performance in detection of a small pH change. KW - Negative impedance convertor KW - Resonance-mode measurement KW - Chemical sensor KW - EIS capacitive sensor Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.snb.2017.03.002 SN - 0925-4005 VL - 248 SP - 1006 EP - 1010 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Miyamoto, Ko-ichiro A1 - Suto, Takeyuki A1 - Werner, Frederik A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Restraining the Diffusion of Photocarriers to Improve the Spatial Resolution of the Chemical Imaging Sensor T2 - MDPI Proceedings Y1 - 2017 U6 - http://dx.doi.org/10.3390/proceedings1040477 N1 - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017 VL - 1 IS - 4 ER - TY - CHAP A1 - Molinnus, Denise A1 - Hardt, Gabriel A1 - Käver, Larissa A1 - Willenberg, Holger S. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology T2 - MDPI Proceedings Y1 - 2017 U6 - http://dx.doi.org/10.3390/proceedings1040506 ER - TY - JOUR A1 - Molinnus, Denise A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Katz, Evgeny A1 - Schöning, Michael Josef T1 - Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips JF - Electroanalysis N2 - The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor. Y1 - 2017 U6 - http://dx.doi.org/10.1002/elan.201700208 SN - 1521-4109 VL - 29 IS - 8 SP - 1840 EP - 1849 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Morais, Paulo V. A1 - Gomes, Vanderley F., Jr. A1 - Silva, Anielle C. A. A1 - Dantas, Noelio O. A1 - Schöning, Michael Josef A1 - Siqueira, José R., Jr. T1 - Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices JF - Journal of Materials Science N2 - The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance–voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film’s surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s10853-017-1369-y SN - 1573-4803 VL - 52 IS - 20 SP - 12314 EP - 12325 PB - Springer CY - Berlin ER - TY - JOUR A1 - Muschallik, Lukas A1 - Molinnus, Denise A1 - Bongaerts, Johannes A1 - Pohl, Martina A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Siegert, Petra A1 - Selmer, Thorsten T1 - (R,R)-Butane-2,3-diol Dehydrogenase from Bacillus clausii DSM 8716T: Cloning and Expression of the bdhA-Gene, and Initial Characterization of Enzyme JF - Journal of Biotechnology N2 - The gene encoding a putative (R,R)-butane-2,3-diol dehydrogenase (bdhA) from Bacillus clausii DSM 8716T was isolated, sequenced and expressed in Escherichia coli. The amino acid sequence of the encoded protein is only distantly related to previously studied enzymes (identity 33–43%) and exhibited some uncharted peculiarities. An N-terminally StrepII-tagged enzyme variant was purified and initially characterized. The isolated enzyme catalyzed the (R)-specific oxidation of (R,R)- and meso-butane-2,3-diol to (R)- and (S)-acetoin with specific activities of 12 U/mg and 23 U/mg, respectively. Likewise, racemic acetoin was reduced with a specific activity of up to 115 U/mg yielding a mixture of (R,R)- and meso-butane-2,3-diol, while the enzyme reduced butane-2,3-dione (Vmax 74 U/mg) solely to (R,R)-butane-2,3-diol via (R)-acetoin. For these reactions only activity with the co-substrates NADH/NAD+ was observed. The enzyme accepted a selection of vicinal diketones, α-hydroxy ketones and vicinal diols as alternative substrates. Although the physiological function of the enzyme in B. clausii remains elusive, the data presented herein clearly demonstrates that the encoded enzyme is a genuine (R,R)-butane-2,3-diol dehydrogenase with potential for applications in biocatalysis and sensor development. Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.jbiotec.2017.07.020 SN - 0168-1656 VL - 258 SP - 41 EP - 50 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Müller, Wolfram A1 - Jung, Alexander A1 - Ahammer, Helmut T1 - Advantages and problems of nonlinear methods applied to analyze physiological time signals: human balance control as an example JF - Scientific Reports Y1 - 2017 SN - 2045-2322 U6 - http://dx.doi.org/10.1038/s41598-017-02665-5 VL - 7 IS - Article number 2464 SP - 1 EP - 11 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Neu, Eugen A1 - Janser, Frank A1 - Khatibi, Akbar A. A1 - Orifici, Adrian C. T1 - Fully Automated Operational Modal Analysis using multi-stage clustering JF - Mechanical Systems and Signal Processing Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.ymssp.2016.07.031 SN - 0888-3270 VL - Vol. 84, Part A SP - 308 EP - 323 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Niemueller, Tim A1 - Neumann, Tobias A1 - Henke, Christoph A1 - Schönitz, Sebastian A1 - Reuter, Sebastian A1 - Ferrein, Alexander A1 - Jeschke, Sabina A1 - Lakemeyer, Gerhard T1 - Improvements for a robust production in the RoboCup logistics league 2016 T2 - RoboCup 2016: Robot World Cup XX. RoboCup 2016. Y1 - 2017 SN - 978-3-319-68792-6 U6 - http://dx.doi.org/10.1007/978-3-319-68792-6_49 SP - 589 EP - 600 PB - Springer CY - Cham ER - TY - CHAP A1 - Niemueller, Tim A1 - Neumann, Tobias A1 - Henke, Christoph A1 - Schönitz, Sebastian A1 - Reuter, Sebastian A1 - Ferrein, Alexander A1 - Jeschke, Sabina A1 - Lakemeyer, Gerhard T1 - International Harting Open Source Award 2016: Fawkes for the RoboCup Logistics League T2 - RoboCup 2016: RoboCup 2016: Robot World Cup XX. RoboCup 2016 Y1 - 2017 SN - 978-3-319-68792-6 U6 - http://dx.doi.org/10.1007/978-3-319-68792-6_53 N1 - Lecture Notes in Computer Science, LNCS, Vol 9776 SP - 634 EP - 642 PB - Springer CY - Cham ER - TY - CHAP A1 - Niemueller, Tim A1 - Zwilling, Frederik A1 - Lakemeyer, Gerhard A1 - Löbach, Matthias A1 - Reuter, Sebastian A1 - Jeschke, Sabina A1 - Ferrein, Alexander T1 - Cyber-Physical System Intelligence T2 - Industrial Internet of Things N2 - Cyber-physical systems are ever more common in manufacturing industries. Increasing their autonomy has been declared an explicit goal, for example, as part of the Industry 4.0 vision. To achieve this system intelligence, principled and software-driven methods are required to analyze sensing data, make goal-directed decisions, and eventually execute and monitor chosen tasks. In this chapter, we present a number of knowledge-based approaches to these problems and case studies with in-depth evaluation results of several different implementations for groups of autonomous mobile robots performing in-house logistics in a smart factory. We focus on knowledge-based systems because besides providing expressive languages and capable reasoning techniques, they also allow for explaining how a particular sequence of actions came about, for example, in the case of a failure. KW - Smart factory KW - Industry 4.0 KW - Multi-robot systems KW - Autonomous mobile robots KW - RoboCup Y1 - 2017 SN - 978-3-319-42559-7 U6 - http://dx.doi.org/10.1007/978-3-319-42559-7_17 N1 - Springer Series in Wireless Technology SP - 447 EP - 472 PB - Springer CY - Cham ER - TY - GEN A1 - Nobisrath, Ulrich A1 - Zündorf, Albert A1 - George, Tobias A1 - Ruben, Jubeh A1 - Kraft, Bodo T1 - Software Stories Guide N2 - Software Stories are a simple graphical notation for requirements analysis and design in agile software projects. Software Stories are based on example scenarios. Example scenarios facilitate the communication between lay people or domain experts and software experts. Y1 - 2017 ER - TY - JOUR A1 - Noureddine, Yacine A1 - Kraff, Oliver A1 - Ladd, Mark E. A1 - Wrede, Karsten H. A1 - Chen, Bixia A1 - Quick, Harald H. A1 - Schaefers, Gregor A1 - Bitz, Andreas T1 - In vitro and in silico assessment of RF-induced heating around intracranial aneurysm clips at 7 Tesla JF - Magnetic Resonance in Medicine Y1 - 2017 U6 - http://dx.doi.org/10.1002/mrm.26650 SN - 1522-2594 IS - Early view PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Oberländer, Jan A1 - Arreola, Julio A1 - Hansen, Christina A1 - Greeff, Anton A1 - Mayer, Marlena A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Impedimetric Biosensor to Enable Fast Evaluation of Gaseous Sterilization Processes T2 - MDPI Proceedings Y1 - 2017 U6 - http://dx.doi.org/10.3390/proceedings1040435 N1 - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017 VL - 1 IS - 4 ER - TY - JOUR A1 - Orzada, Stephan A1 - Bitz, Andreas A1 - Johst, Sören A1 - Gratz, Marcel A1 - Völker, Maximilian N. A1 - Kraff, Oliver A1 - Abuelhaija, Ashraf A1 - Fiedler, Thomas M. A1 - Solbach, Klaus A1 - Quick, Harald H. A1 - Ladd, Mark E. T1 - Analysis of an integrated 8-Channel Tx/Rx body array for use as a body coil in 7-Tesla MRI JF - Frontiers in Physics Y1 - 2017 U6 - http://dx.doi.org/10.3389/fphy.2017.00017 SN - 2296-424X N1 - Article number 17 VL - 5 IS - Jun ER - TY - JOUR A1 - Peloni, Alessandro A1 - Dachwald, Bernd A1 - Ceriotti, Matteo T1 - Multiple near-earth asteroid rendezvous mission: Solar-sailing options JF - Advances in Space Research Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.asr.2017.10.017 SN - 0273-1177 IS - In Press, Corrected Proof PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Peloni, Alessandro A1 - Dachwald, Bernd A1 - Ceriotti, Matteo T1 - Multiple NEA rendezvous mission: Solar sailing options T2 - Fourth International Symposium on Solar Sailing N2 - The scientific interest in near-Earth asteroids (NEAs) and the classification of some of those as potentially hazardous asteroid for the Earth stipulated the interest in NEA exploration. Close-up observations of these objects will increase drastically our knowledge about the overall NEA population. For this reason, a multiple NEA rendezvous mission through solar sailing is investigated, taking advantage of the propellantless nature of this groundbreaking propulsion technology. Considering a spacecraft based on the DLR/ESA Gossamer technology, this work focuses on the search of possible sequences of NEA encounters. The effectiveness of this approach is demonstrated through a number of fully-optimized trajectories. The results show that it is possible to visit five NEAs within 10 years with near-term solar-sail technology. Moreover, a study on a reduced NEA database demonstrates the reliability of the approach used, showing that 58% of the sequences found with an approximated trajectory model can be converted into real solar-sail trajectories. Lastly, this second study shows the effectiveness of the proposed automatic optimization algorithm, which is able to find solutions for a large number of mission scenarios without any input required from the user. KW - Multiphase KW - Trajectory Optimization KW - Automated Optimization KW - Gossamer KW - Sequence-Search Y1 - 2017 N1 - Fourth International Symposium on Solar Sailing (ISSS 2017), Kyoto, Japan, 17-20 Jan 2017. http://www.jsforum.or.jp/ISSS2017/ SP - 1 EP - 11 ER - TY - CHAP A1 - Pfaff, Raphael T1 - Analysis of Big Data Streams to obtain Braking Reliability Information for Train Protection systems T2 - Asia-Pacific Conference of the Prognostics and Health Management Society Y1 - 2017 N1 - Asia-Pacific Conference of the Prognostics and Health Management Society, Jeju, Korea 2017 SP - 1 EP - 7 ER - TY - CHAP A1 - Pfaff, Raphael A1 - Moshiri, Amir A1 - Reich, Alexander A1 - Gäbel, Markus T1 - Modelling of the effect of sanding on the wheel-rail adhesion area T2 - First International Conference on Rail Transportation Y1 - 2017 N1 - 2017 ICRT; International Conference on Rail Transportation <1, 2017, Chengdu, China> SP - 1 EP - 7 ER - TY - CHAP A1 - Pfaff, Raphael A1 - Schmidt, B. D. A1 - Enning, Manfred T1 - Towards inclusion of the freight rail system in the industrial internet of things - Wagon 4.0 T2 - Stephenson Conference, London, March 2017 Y1 - 2017 N1 - IMechE Stephenson Conference <2017, London, United Kingdom> SP - 1 EP - 10 ER - TY - CHAP A1 - Pfaff, Raphael A1 - Shahidi, Parham A1 - Enning, Manfred T1 - Connected freight rail rolling stock: a modular approach integrating sensors, actors and cyber physical systems for operational advantages and condition based maintenance T2 - Asia-Pacific Conference of the Prognostics and Health Management Society Y1 - 2017 N1 - Asia-Pacific Conference of the Prognostics and Health Management Society, Jeju, Korea 2017 SP - 1 EP - 7 ER - TY - JOUR A1 - Pilas, Johanna A1 - Yazici, Yasemen A1 - Selmer, Thorsten A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Optimization of an amperometric biosensor array for simultaneous measurement of ethanol, formate, d- and l-lactate JF - Electrochimica Acta N2 - The immobilization of NAD+-dependent dehydrogenases, in combination with a diaphorase, enables the facile development of multiparametric sensing devices. In this work, an amperometric biosensor array for simultaneous determination of ethanol, formate, d- and l-lactate is presented. Enzyme immobilization on platinum thin-film electrodes was realized by chemical cross-linking with glutaraldehyde. The optimization of the sensor performance was investigated with regard to enzyme loading, glutaraldehyde concentration, pH, cofactor concentration and temperature. Under optimal working conditions (potassium phosphate buffer with pH 7.5, 2.5 mmol L-1 NAD+, 2.0 mmol L-1 ferricyanide, 25 °C and 0.4% glutaraldehyde) the linear working range and sensitivity of the four sensor elements was improved. Simultaneous and cross-talk free measurements of four different metabolic parameters were performed successfully. The reliable analytical performance of the biosensor array was demonstrated by application in a clarified sample of inoculum sludge. Thereby, a promising approach for on-site monitoring of fermentation processes is provided. KW - Simultaneous determination KW - Enzymatic biosensor KW - Diaphorase KW - Dehydrogenase Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.electacta.2017.07.119 SN - 0013-4686 VL - 251 SP - 256 EP - 262 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Nanomaterial-Modified Capacitive Field-Effect Biosensors T2 - Springer Series on Chemical Sensors and Biosensors (Methods and Applications) N2 - The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte–insulator–semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing. KW - Biomolecular logic gate KW - DNA KW - Enzyme biosensor KW - Field-effect sensor KW - Gold nanoparticle Y1 - 2017 U6 - http://dx.doi.org/10.1007/5346_2017_2 SP - 1 EP - 25 PB - Springer CY - Berlin, Heidelberg ER - TY - JOUR A1 - Poghossian, Arshak A1 - Werner, Frederik A1 - Buniatyan, V. V. A1 - Wagner, Torsten A1 - Miamoto, K. A1 - Yoshinobu, T. A1 - Schöning, Michael Josef T1 - Towards addressability of light-addressable potentiometric sensors: Shunting effect of non-illuminated region and cross-talk JF - Sensor and Actuators B: Chemical N2 - The LAPS (light-addressable potentiometric sensor) platform is one of the most attractive approaches for chemical and biological sensing with many applications ranging from pH and ion/analyte concentration measurements up to cell metabolism detection and chemical imaging. However, although it is generally accepted that LAPS measurements are spatially resolved, the light-addressability feature of LAPS devices has not been discussed in detail so far. In this work, an extended electrical equivalent-circuit model of the LAPS has been presented, which takes into account possible cross-talk effects due to the capacitive coupling of the non-illuminated region. A shunting effect of the non-illuminated area on the measured photocurrent and addressability of LAPS devices has been studied. It has been shown, that the measured photocurrent will be determined not only by the local interfacial potential in the illuminated region but also by possible interfacial potential changes in the non-illuminated region, yielding cross-talk effects. These findings were supported by the experimental investigations of a penicillin-sensitive multi-spot LAPS and a metal-insulator-semiconductor LAPS as model systems. Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.snb.2017.01.047 SN - 0925-4005 IS - 244 SP - 1071 EP - 1079 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Rajan, S. A1 - Butenweg, Christoph A1 - Dalguer, L. A. A1 - An, J. H. A1 - Renault, P. A1 - Klinkel, S. T1 - Fragility curves for a three-storey reinforced concrete test structure of the international benchmark SMART 2013 T2 - 16th World Conference on Earthquake, 16WCEE 2017 Santiago Chile, January 9th to 13th 2017 Y1 - 2017 N1 - Paper No 2119 PB - Chilean Association on Seismology and Earthquake Engineering (ACHISINA) ER - TY - CHAP A1 - Rajan, Sreelakshmy A1 - Kubalski, Thomas A1 - Altay, Okyay A1 - Dalguer, Luis A A1 - Butenweg, Christoph T1 - Multi-dimensional fragility analysis of a RC building with components using response surface method T2 - 24th International Conference on Structural Mechanics in Reactor Technology, Busan, Korea, 20-25 August, 2017 N2 - Conventional fragility curves describe the vulnerability of the main structure under external hazards. However, in complex structures such as nuclear power plants, the safety or the risk depends also on the components associated with a system. The classical fault tree analysis gives an overall view of the failure and contains several subsystems to the main event, however, the interactions in the subsystems are not well represented. In order to represent the interaction of the components, a method suggested by Cimellaro et al. (2006) using multidimensional performance limit state functions to obtain the system fragility curves is adopted. This approach gives the possibility of deriving the cumulative fragility taking into account the interaction of the response of different components. In this paper, this approach is used to evaluate seismic risk of a representative electrical building infrastructure, including the component, of a nuclear power plant. A simplified model of the structure, with nonlinear material behavior is employed for the analysis in Abaqus©. The input variables considered are the material parameters, boundary conditions and the seismic input. The variability of the seismic input is obtained from selected ground motion time histories of spectrum compatible synthetic ccelerograms. Unlike the usual Monte Carlo methods used for the probabilistic analysis of the structure, a computationally effective response surface method is used. This method reduces the computational effort of the calculations by reducing the required number of samples. Y1 - 2017 SN - 9781510856776 SP - 3126 EP - 3135 PB - International Assn for Structural Mechanics in Reactor Technology (IASMiRT) CY - Raleigh, USA ER - TY - JOUR A1 - Richter, Charlotte A1 - Braunstein, Bjoern A1 - Winnard, Andrew A1 - Nasser, Mona A1 - Weber, T. T1 - Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review JF - Frontiers in physiology Y1 - 2017 U6 - http://dx.doi.org/10.3389/fphys.2017.00583 IS - 8, article 583 ER - TY - JOUR A1 - Rietsch, Stefan H. G. A1 - Pfaffenrot, Viktor A1 - Bitz, Andreas A1 - Orzada, Stephan A1 - Brunheim, Sascha A1 - Lazik-Palm, Andrea A1 - Theysohn, Jens M. A1 - Ladd, Mark E. A1 - Quick, Harald H. A1 - Kraff, Oliver T1 - An 8-channel transceiver 7-channel receive RF coil setup for high SNR ultrahigh-field MRI of the shoulder at 7T JF - Medical Physics Y1 - 2017 U6 - http://dx.doi.org/10.1002/mp.12612 SN - 0094-2405 IS - Article in press PB - Wiley CY - Hoboken ER - TY - CHAP A1 - Rosin, J. A1 - Mykoniou, K. A1 - Butenweg, Christoph T1 - Analysis Of Base Isolated Liquid Storage Tanks With 3D Fsi-Analysis As Well As Simplified Approaches T2 - 16th World Conference on Earthquake Engineering, 16WCEE 2017 Santiago Chile, January 9th to 13th 2017 N2 - Tanks are preferably designed, for cost-saving reasons, as circular, cylindrical, thin-walled shells. In case of seismic excitation, these constructions are highly vulnerable to stability failures. An earthquake-resistant design of rigidly supported tanks for high seismic loading demands, however, uneconomic wall thicknesses. A cost-effective alternative can be provided by base isolation systems. In this paper, a simplified seismic design procedure for base isolated tanks is introduced, by appropriately modifying the standard mechanical model for flexible, rigidly supported tanks. The non-linear behavior of conventional base isolation systems becomes an integral part of a proposed simplified process, which enables the assessment of the reduced hydrodynamic forces acting on the tank walls and the corresponding stress distribution. The impulsive and convective actions of the liquid are taken into account. The validity of this approach is evaluated by employing a non-linear fluid-structure interaction algorithm of finite element method. Special focus is placed on the boundary conditions imposed from the base isolation and the resulting hydrodynamic pressures. Both horizontal and vertical component of ground motion are considered in order to study the principal effects of the base isolation on the pressure distribution of the tank walls. The induced rocking effects associated with elastomeric bearings are discussed. The results manifest that base isolated tanks can be designed for seismic loads by means of the proposed procedure with sufficient accuracy, allowing to dispense with numerically expensive techniques. KW - liquid storage tank KW - seismic isolation KW - elastomeric bearing KW - friction pendulum bearing KW - simplified approach Y1 - 2017 N1 - Paper No 2246 SP - 1 EP - 14 PB - Chilean Association on Seismology and Earthquake Engineering (ACHISINA) ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Schöning, Michael Josef A1 - Selmer, Thorsten T1 - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid JF - Applied Biochemistry and Biotechnology N2 - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s12010-017-2578-1 SN - 1559-0291 VL - 183 SP - 566 EP - 581 PB - Springer CY - Berlin ER - TY - CHAP A1 - Samuelsson, K. A1 - Scheer, Nico A1 - Wilson, I. A1 - Wolf, C.R. A1 - Henderson, C.J. ED - Chackalamannil, Samuel T1 - Genetically Humanized Animal Models T2 - Comprehensive Medicinal Chemistry III. 3rd Edition N2 - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development. KW - Chimeric liver-humanized mice KW - Drug distribution KW - Drug metabolism KW - Toxicology KW - Knockout mice Y1 - 2017 SN - 978-0-12-803201-5 U6 - http://dx.doi.org/10.1016/B978-0-12-409547-2.12376-5 SP - 130 EP - 149 PB - Elsevier CY - Saint Louis ER - TY - CHAP A1 - Sauerborn, Markus A1 - Liebenstund, Lena A1 - Raue, Markus A1 - Mang, Thomas A1 - Herrmann, Ulf A1 - Dueing, Andreas T1 - Analytic method for material aging and quality analyzing to forecast long time stability of plastic micro heliostat components T2 - AIP Conference Proceedings Y1 - 2017 U6 - http://dx.doi.org/10.1063/1.4984388 VL - 1850 IS - 1 SP - 030045-1 EP - 030045-8 ER - TY - JOUR A1 - Savitskaya, I. S. A1 - Kistaubayeva, A. S. A1 - Digel, Ilya A1 - Shokatayeva, D. H. T1 - Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials JF - Eurasian Chemico-Technological Journal Y1 - 2017 U6 - http://dx.doi.org/10.18321/ectj670 SN - 2522-4867 VL - 19 IS - 3 SP - 255 EP - 264 ER - TY - CHAP A1 - Schiffer, Stefan A1 - Ferrein, Alexander T1 - A System Layout for Cognitive Service Robots T2 - Cognitive Robot Architectures. Proceedings of EUCognition 2016 Y1 - 2017 SN - 1613-0073 N1 - CEUR-WS Vol-1855 SP - 44 EP - 45 ER - TY - CHAP A1 - Schildt, P. A1 - Braun, Carsten A1 - Marcocca, P. T1 - Flight testing the extra 330LE flying testbed T2 - 48th Annual International Symposium of the Society of Flight Test Engineers 2017 Y1 - 2017 SN - 978-151085387-4 N1 - 48th Annual International Symposium of the Society of Flight Test Engineers 2017, SFTE 2017; Destin; United States; 30 October 2017 through 2 November 2017 SP - 349 EP - 362 ER - TY - CHAP A1 - Schlemmer, Katharina A1 - Porst, Dariusz A1 - Bassam, Rasha A1 - Artmann, Gerhard A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 100 EP - 101 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Schleupen, Josef A1 - Engemann, Heiko A1 - Bagheri, Mohsen A1 - Kallweit, Stephan A1 - Dahmann, Peter T1 - Developing a climbing maintenance robot for tower and rotor blade service of wind turbines T2 - Advances in Robot Design and Intelligent Control : Proceedings of the 25th Conference on Robotics in Alpe-Adria-Danube Region (RAAD16) Y1 - 2017 SN - 978-3-319-49058-8 U6 - http://dx.doi.org/10.1007/978-3-319-49058-8_34 N1 - Advances in Robot Design and Intelligent Control ; Vol. 540 SP - 310 EP - 319 PB - Springer CY - Cham ER -