TY - JOUR A1 - Akimbekov, Nuraly A1 - Qiao, Xiaohui A1 - Digel, Ilya A1 - Abdieva, Gulzhamal A1 - Ualieva, Perizat A1 - Zhubanova, Azhar T1 - The effect of leonardite-derived amendments on soil microbiome structure and potato yield JF - Agriculture N2 - Humic substances originating from various organic matters can ameliorate soil properties, stimulate plant growth, and improve nutrient uptake. Due to the low calorific heating value, leonardite is rather unsuitable as fuel. However, it may serve as a potential source of humic substances. This study was aimed at characterizing the leonardite-based soil amendments and examining the effect of their application on the soil microbial community, as well as on potato growth and tuber yield. A high yield (71.1%) of humic acid (LHA) from leonardite has been demonstrated. Parental leonardite (PL) and LHA were applied to soil prior to potato cultivation. The 16S rRNA sequencing of soil samples revealed distinct relationships between microbial community composition and the application of leonardite-based soil amendments. Potato tubers were planted in pots in greenhouse conditions. The tubers were harvested at the mature stage for the determination of growth and yield parameters. The results demonstrated that the LHA treatments had a significant effect on increasing potato growth (54.9%) and tuber yield (66.4%) when compared to the control. The findings highlight the importance of amending leonardite-based humic products for maintaining the biogeochemical stability of soils, for keeping their healthy microbial community structure, and for increasing the agronomic productivity of potato plants. Y1 - 2020 U6 - http://dx.doi.org/10.3390/agriculture10050147 VL - 10 IS - Art. 147 SP - 1 EP - 17 PB - MDPI CY - Basel ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Sherelkhan, Dinara K. A1 - Lutfor, Afzalunnessa B. A1 - Razzaque, Mohammed S. T1 - Vitamin D and the Host-Gut Microbiome: A Brief Overview JF - Acta Histochemica et Cytochemica N2 - There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression. Y1 - 2020 U6 - http://dx.doi.org/10.1267/ahc.20011 SN - 1347-5800 VL - 53 IS - 3 SP - 33 EP - 42 PB - Japan Society of Histochemistry and Cytochemistry CY - Osaka ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Tastambek, Kuanysh T. A1 - Marat, Adel K. A1 - Turaliyeva, Moldir A. A1 - Kaiyrmanova, Gulzhan K. T1 - Biotechnology of Microorganisms from Coal Environments: From Environmental Remediation to Energy Production JF - Biology N2 - It was generally believed that coal sources are not favorable as live-in habitats for microorganisms due to their recalcitrant chemical nature and negligible decomposition. However, accumulating evidence has revealed the presence of diverse microbial groups in coal environments and their significant metabolic role in coal biogeochemical dynamics and ecosystem functioning. The high oxygen content, organic fractions, and lignin-like structures of lower-rank coals may provide effective means for microbial attack, still representing a greatly unexplored frontier in microbiology. Coal degradation/conversion technology by native bacterial and fungal species has great potential in agricultural development, chemical industry production, and environmental rehabilitation. Furthermore, native microalgal species can offer a sustainable energy source and an excellent bioremediation strategy applicable to coal spill/seam waters. Additionally, the measures of the fate of the microbial community would serve as an indicator of restoration progress on post-coal-mining sites. This review puts forward a comprehensive vision of coal biodegradation and bioprocessing by microorganisms native to coal environments for determining their biotechnological potential and possible applications. Y1 - 2022 U6 - http://dx.doi.org/10.3390/biology11091306 SN - 2079-7737 N1 - This article belongs to the Special Issue "Microbial Ecology and Evolution in Extreme Environments" VL - 11 IS - 9 PB - MDPI CY - Basel ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Tastambek, Kuanysh T. A1 - Sherelkhan, Dinara K. A1 - Jussupova, Dariya B. A1 - Altynbay, Nazym P. T1 - Low-rank coal as a source of humic substances for soil amendment and fertility management JF - Agriculture N2 - Humic substances (HS), as important environmental components, are essential to soil health and agricultural sustainability. The usage of low-rank coal (LRC) for energy generation has declined considerably due to the growing popularity of renewable energy sources and gas. However, their potential as soil amendment aimed to maintain soil quality and productivity deserves more recognition. LRC, a highly heterogeneous material in nature, contains large quantities of HS and may effectively help to restore the physicochemical, biological, and ecological functionality of soil. Multiple emerging studies support the view that LRC and its derivatives can positively impact the soil microclimate, nutrient status, and organic matter turnover. Moreover, the phytotoxic effects of some pollutants can be reduced by subsequent LRC application. Broad geographical availability, relatively low cost, and good technical applicability of LRC offer the advantage of easy fulfilling soil amendment and conditioner requirements worldwide. This review analyzes and emphasizes the potential of LRC and its numerous forms/combinations for soil amelioration and crop production. A great benefit would be a systematic investment strategy implicating safe utilization and long-term application of LRC for sustainable agricultural production. KW - soil remediation KW - crop yield KW - soil health KW - soil amendment KW - low-rank coal Y1 - 2021 U6 - http://dx.doi.org/10.3390/agriculture11121261 SN - 2077-0472 N1 - This article belongs to the Special Issue "From Waste to Fertilizer in Sustainable Agriculture" VL - 11 IS - 12 PB - MDPI CY - Basel ER - TY - JOUR A1 - Akimbekov, Nuraly Shardarbekovich A1 - Mansurov, Zulkhair A1 - Jandosov, J. A1 - Digel, Ilya A1 - Gossmann, Matthias A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül A1 - Zhubanova, Azhar A. T1 - Wound healing activity of carbonized rice husk N2 - The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls. KW - Wundheilung KW - Epithel KW - Fibroblast KW - carbonized rice husk KW - wound healing KW - epithelization KW - human dermal fibroblasts Y1 - 2013 PB - Trans Tech Publications, Switzerland CY - Bäch ER - TY - JOUR A1 - Al-Kaidy, Huschyar A1 - Duwe, Anna A1 - Huster, Manuel A1 - Muffler, Kai A1 - Schlegel, Christin A1 - Sieker, Tim A1 - Stadtmüller, Ralf A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Biotechnologie und Bioverfahrenstechnik – Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen JF - Chemie Ingenieur Technik N2 - Biotechnologie und die mit ihr verbundenen technischen Prozesse prägen seit Jahrtausenden die Entwicklung der Menschheit. Ausgehend von empirischen Verfahren, insbesondere zur Herstellung von Lebensmitteln und täglichen Gebrauchsgütern, haben sich diese Disziplinen zu einem der innovativsten Zukunftsfelder entwickelt. Durch das immer detailliertere Verständnis zellulärer Vorgänge können mittlerweile Produktionsstämme gezielt optimiert werden. Im Zusammenspiel mit moderner Prozesstechnik können so eine Vielzahl von Bulk- und Feinchemikalien sowie Pharmazeutika effizient hergestellt werden. In diesem Artikel werden exemplarisch einige der aktuellen Trends vorgestellt. Y1 - 2014 U6 - http://dx.doi.org/10.1002/cite.201400083 SN - 0009-286X VL - 86 IS - 12 SP - 2215 EP - 2225 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Al-Kaidy, Huschyar A1 - Duwe, Anna A1 - Huster, Manuel A1 - Muffler, Kai A1 - Schlegel, Christin A1 - Tim, Sieker A1 - Stadtmüller, Ralf A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Biotechnology and bioprocess engineering – from the first ullmann's article to recent trends JF - ChemBioEng Reviews N2 - For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed. Y1 - 2015 U6 - http://dx.doi.org/10.1002/cben.201500008 VL - 2 IS - 3 SP - 175 EP - 184 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Al-Kaidy, Huschyar A1 - Kuthan, Kai A1 - Hering, Thomas A1 - Tippkötter, Nils T1 - Aqueous droplets used as enzymatic microreactors and their electromagnetic actuation JF - Journal of Visualized Experiments N2 - For the successful implementation of microfluidic reaction systems, such as PCR and electrophoresis, the movement of small liquid volumes is essential. In conventional lab-on-a-chip-platforms, solvents and samples are passed through defined microfluidic channels with complex flow control installations. The droplet actuation platform presented here is a promising alternative. With it, it is possible to move a liquid drop (microreactor) on a planar surface of a reaction platform (lab-in-a-drop). The actuation of microreactors on the hydrophobic surface of the platform is based on the use of magnetic forces acting on the outer shell of the liquid drops which is made of a thin layer of superhydrophobic magnetite particles. The hydrophobic surface of the platform is needed to avoid any contact between the liquid core and the surface to allow a smooth movement of the microreactor. On the platform, one or more microreactors with volumes of 10 µL can be positioned and moved simultaneously. The platform itself consists of a 3 x 3 matrix of electrical double coils which accommodate either neodymium or iron cores. The magnetic field gradients are automatically controlled. By variation of the magnetic field gradients, the microreactors' magnetic hydrophobic shell can be manipulated automatically to move the microreactor or open the shell reversibly. Reactions of substrates and corresponding enzymes can be initiated by merging the microreactors or bringing them into contact with surface immobilized catalysts. Y1 - 2016 U6 - http://dx.doi.org/10.3791/54643 SN - 1940-087X IS - Issue 126 ER - TY - JOUR A1 - Al-Kaidy, Huschyar A1 - Tippkötter, Nils T1 - Superparamagnetic hydrophobic particles as shell material for digital microfluidic droplets and proof-of-principle reaction assessments with immobilized laccase JF - Engineering in Life Sciences N2 - In the field of biotechnology and molecular biology, the use of small liquid volumes has significant advantages. In particular, screening and optimization runs with acceptable amounts of expensive and hardly available catalysts, reagents, or biomolecules are feasible with microfluidic technologies. The presented new microfluidic system is based on the inclusion of small liquid volumes by a protective shell of magnetizable microparticles. Hereby, discrete aqueous microreactor drops with volumes of 1–30 μL can be formed on a simple planar surface. A digital movement and manipulation of the microreactor is performed by overlapping magnetic forces. The magnetic forces are generated by an electrical coil matrix positioned below a glass plate. With the new platform technology, several discrete reaction compartments can be moved simultaneously on one surface. Due to the magnetic fields, the reactors can even be merged to initiate reactions by mixing or positioned above surface-immobilized catalysts and then opened by magnetic force. Comparative synthesis routes of the magnetizable shell particles and superhydrophobic glass slides including their performance and stability with the reaction platform are described. The influence of diffusive mass transport during the catalyzed reaction is discussed by evaluation finite element model of the microreactor. Furthermore, a first model dye reaction of the enzyme laccase has been established. Y1 - 2016 U6 - http://dx.doi.org/10.1002/elsc.201400124 VL - 16 IS - 3 SP - 222 EP - 230 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Albanna, W. A1 - Conzen, C. A1 - Weiss, M. A1 - Clusmann, H. A1 - Fuest, M. A1 - Mueller, M. A1 - Brockmann, M.A. A1 - Vilser, W. A1 - Schmidt-Trucksäss, A. A1 - Hoellig, A. A1 - Seiz, M. A1 - Thomé, C. A1 - Kotliar, Konstantin A1 - Schubert, G.A. T1 - Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study JF - PLoS ONE N2 - Background Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. Methods In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2–14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling. Results Image quality was satisfactory in the majority of cases (93.3%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion. Conclusion RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort. Y1 - 2016 U6 - http://dx.doi.org/10.1371/journal.pone.0158781 SN - 1932-6203 VL - 11 IS - 7 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Albanna, Walid A1 - Conzen, Catharina A1 - Weiss, Miriam A1 - Seyfried, Katharina A1 - Kotliar, Konstantin A1 - Schmidt, Tobias Philip A1 - Kuerten, David A1 - Hescheler, Jürgen A1 - Bruecken, Anne A1 - Schmidt-Trucksäss, Arno A1 - Neumaier, Felix A1 - Wiesmann, Martin A1 - Clusmann, Hans A1 - Schubert, Gerrit Alexander T1 - Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis JF - Frontiers in Neurology N2 - Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus. Y1 - 2021 U6 - http://dx.doi.org/10.3389/fneur.2021.690183 SN - 1664-2295 VL - 12 IS - 12 SP - 1 EP - 15 ER - TY - JOUR A1 - Albanna, Walid A1 - Kotliar, Konstantin A1 - Lüke, Jan Niklas A1 - Alpdogan, Serdar A1 - Conzen, Catharina A1 - Lindauer, Ute A1 - Clusmann, Hans A1 - Hescheler, Jürgen A1 - Vilser, Walthard A1 - Schneider, Toni A1 - Schubert, Gerrit Alexander T1 - Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis JF - Plos one N2 - Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals. Y1 - 2018 U6 - http://dx.doi.org/10.1371/journal.pone.0204689 VL - 13 IS - 10 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Albanna, Walid A1 - Lueke, Jan Niklas A1 - Sjapic, Volha A1 - Kotliar, Konstantin A1 - Hescheler, Jürgen A1 - Clusmann, Hans A1 - Sjapic, Sergej A1 - Alpdogan, Serdan A1 - Schneider, Toni A1 - Schubert, Gerrit Alexander A1 - Neumaier, Felix T1 - Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina JF - Current Eye Research Y1 - 2017 U6 - http://dx.doi.org/10.1080/02713683.2017.1339807 SN - 1460-2202 IS - Article in press SP - 1 EP - 9 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Albanna, Walid A1 - Lüke, Jan Niklas A1 - Schubert, Gerrit Alexander A1 - Dibué-Adjei, Maxine A1 - Kotliar, Konstantin A1 - Hescheler, Jürgen A1 - Clusmann, Hans A1 - Steiger, Hans-Jakob A1 - Hänggi, Daniel A1 - Kamp, Marcel A. A1 - Schneider, Toni A1 - Neumaier, Felix T1 - Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity JF - Molecular and Cellular Neuroscience Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.mcn.2019.03.003 SN - 1044-7431 VL - 96 IS - 4 SP - 35 EP - 46 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, A. A1 - Baltzopoulos, V. T1 - Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivo JF - Journal of Biomechanics Y1 - 2008 U6 - http://dx.doi.org/10.1016/j.jbiomech.2008.04.020 SN - 0021-9290 VL - 41 SP - 2211 EP - 2218 ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans JF - European Journal of Applied Physiology Y1 - 2013 U6 - http://dx.doi.org/10.1007/s00421-012-2585-4 SN - 1439-6327 VL - 113 IS - 6 SP - 1605 EP - 1615 PB - Springer CY - Berlin ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy JF - Biological Cybernetics Y1 - 2006 U6 - http://dx.doi.org/10.1007/s00422-006-0070-z SN - 1432-0770 VL - 95 IS - 1 SP - 87 EP - 96 ER - TY - JOUR A1 - Alebouyeh Samami, Behzad A1 - Pieper, Martin A1 - Breitbach, Gerd A1 - Hodapp, Josef T1 - Heat production in the windings of the stators of electric machines under stationary condition JF - Heat and mass transfer N2 - In electric machines due to high currents and resistive losses (joule heating) heat is produced. To avoid damages by overheating the design of effective cooling systems is required. Therefore the knowledge of heat sources and heat transfer processes is necessary. The purpose of this paper is to illustrate a good and effective calculation method for the temperature analysis based on homogenization techniques. These methods have been applied for the stator windings in a slot of an electric machine consisting of copper wires and resin. The key quantity here is an effective thermal conductivity, which characterizes the heterogeneous wire resin-arrangement inside the stator slot. To illustrate the applicability of the method, the analysis of a simplified, homogenized model is compared with the detailed analysis of temperature behavior inside a slot of an electric machine according to the heat generation. We considered here only the stationary situation. The achieved numerical results are accurate and show that the applied homogenization technique works in practice. Finally the results of simulations for the two cases, the original model of the slot and the homogenized model chosen for the slot (unit cell), are compared to experimental results. Y1 - 2014 U6 - http://dx.doi.org/10.1007/s00231-014-1371-8 SN - 0947-7411 (Print) ; 1432-1181 (E-Journal) VL - 50 SP - 1707 EP - 1716 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Aletsee, Ludwig A1 - Baumann, Marcus T1 - A laboratory incubator equipped with facilities to automatically simulate natural irradiance JF - Boletim do Instituto Oceanográfico / Universidade de São Paulo Y1 - 1991 SN - 1982-436X; 0080-6331 VL - Vol. 39 IS - No. 2 SP - 155 EP - 159 ER - TY - JOUR A1 - Alexopoulos, Spiros T1 - Biogas systems: basics, biogas multifunction, principle of fermentation and hybrid application with a solar tower for the treatment of waste animal manure JF - Journal of Engineering Science and Technology Review N2 - Two of the main environmental problems of today’s society are the continuously increasing production of organic wastes as well as the increase of carbon dioxide in the atmosphere and the related green house effect. A way to solve these problems is the production of biogas. Biogas is a combustible gas consisting of methane, carbon dioxide and small amounts of other gases and trace elements. Production of biogas through anaerobic digestion of animal manure and slurries as well as of a wide range of digestible organic wastes and agricultural residues, converts these substrates into electricity and heat and offers a natural fertiliser for agriculture. The microbiological process of decomposition of organic matter, in the absence of oxygen takes place in reactors, called digesters. Biogas can be used as a fuel in a gas turbine or burner and can be used in a hybrid solar tower system offering a solution for waste treatment of agricultural and animal residues. A solar tower system consists of a heliostat field, which concentrates direct solar irradiation on an open volumetric central receiver. The receiver heats up ambient air to temperatures of around 700°C. The hot air’s heat energy is transferred to a steam Rankine cycle in a heat recovery steam generator (HRSG). The steam drives a steam turbine, which in turn drives a generator for producing electricity. In order to increase the operational hours of a solar tower power plant, a heat storage system and/ or hybridization may be considered. The advantage of solar-fossil hybrid power plants, compared to solar-only systems, lies in low additional investment costs due to an adaptable solar share and reduced technical and economical risks. On sunny days the hybrid system operates in a solar-only mode with the central receiver and on cloudy days and at night with the gas turbine only. As an alternative to methane gas, environmentally neutral biogas can be used for operating the gas turbine. Hence, the hybrid system is operated to 100% from renewable energy sources Y1 - 2012 SN - 1791-2377 N1 - Special Issue on Renewable Energy Systems VL - 5 IS - 4 SP - 48 EP - 55 ER - TY - JOUR A1 - Alexopoulos, Spiros T1 - Simulation model for the transient process behaviour of solar aluminium recycling in a rotary kiln JF - Applied Thermal Engineering Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.applthermaleng.2015.01.007 SN - 1359-4311 N1 - Autor im Original: Spiridon O. Alexopoulos VL - 78 SP - 387 EP - 396 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Alexopoulos, Spiros A1 - Breitbach, Gerd A1 - Hoffschmidt, Bernhard A1 - Stobbe, P. T1 - Computational fluid flow of porous resic ceramic filtering modules and optimization of the channel edge form geometry JF - Proceedings : April 14 - 18, 2008, Leipzig, Germany / hosted by VDI, Society for Chemical and Process Engineering . Vol 2 Y1 - 2008 N1 - Verein Deutscher Ingenieure ; World Filtration Congress ; (10 : ; 2008.04.14-18 : ; Leipzig) ; WFC ; (10 : ; 2008.04.14-18 : ; Leipzig) SP - 300 EP - 304 PB - Filtech Exhibitions CY - Meerbusch ER - TY - JOUR A1 - Alexopoulos, Spiros A1 - Breitbach, Gerd A1 - Hoffschmidt, Bernhard A1 - Stobbe, P. T1 - Optimization of the geometry of porous SiC ceramic filtering modules using numerical methods JF - Developments in porous, biological and geopolymer ceramics : a collection of papers presented at the 31st International Conference on Advanced Ceramics and Composites, January 21 - 26, 2007, Daytona Beach, Florida ; [papers presented at the Symposium on Porous Ceramics: Novel Developments and Applications] / ed.: Manuel Brito ... Vol. ed.: Jonathan Salem ... The American Ceramics Society Y1 - 2008 SN - 9780470196403 N1 - Ceramic engineering and science proceedings ; 28,9 SP - 95 EP - 104 PB - Wiley CY - Hoboken, NJ ER - TY - JOUR A1 - Alexopoulos, Spiros A1 - Hoffschmidt, Bernhard T1 - Solar tower power plant in Germany and future perspectives of the development of the technology in Greece and Cyprus JF - Renewable Energy . 35 (2010), H. 7 Y1 - 2010 SN - 0960-1481 SP - 1352 EP - 1356 ER - TY - JOUR A1 - Alexopoulos, Spiros A1 - Hoffschmidt, Bernhard T1 - Solarthermische Kraftwerke mit thermischen Speichern JF - Chemie Ingenieur Technik. 82 (2010), H. 9 Y1 - 2010 SN - 1522-2640 N1 - Special Issue: ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen V9.01 [Abstract des Vortrags] SP - 1606 EP - 1606 ER - TY - JOUR A1 - Alexopoulos, Spiros A1 - Hoffschmidt, Bernhard T1 - Advances in solar tower technology JF - Wiley interdisciplinary reviews : Energy and Environment : WIREs Y1 - 2017 U6 - http://dx.doi.org/10.1002/wene.217 SN - 2041-840X VL - 6 IS - 1 SP - 1 EP - 19 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Alexyuk, Madina A1 - Bogoyavlenskiy, Andrey A1 - Alexyuk, Pavel A1 - Moldakhanov, Yergali A1 - Berezin, Vladimir A1 - Digel, Ilya T1 - Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity JF - MicrobiologyOpen N2 - Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40% and 37% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before. KW - ecological structure KW - metagenomics KW - microbial diversity KW - shotgun sequencing KW - Small Aral Sea Y1 - 2021 U6 - http://dx.doi.org/10.1002/mbo3.1142 SN - 2045-8827 VL - 10 IS - 1 SP - 1 EP - 10 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Alhwarin, Faraj A1 - Ferrein, Alexander A1 - Scholl, Ingrid T1 - IR stereo kinect: improving depth images by combining structured light with IR stereo Y1 - 2014 SP - 1 EP - 9 ER - TY - JOUR A1 - Allefeld, Carsten A1 - Bialonski, Stephan T1 - Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains JF - Physical Review E Y1 - 2007 U6 - http://dx.doi.org/10.1103/PhysRevE.76.066207 SN - 2470-0053 VL - 76 IS - 6 SP - 066207 ER - TY - JOUR A1 - Almajhdi, Fahad N. A1 - Senger, Tilo A1 - Amer, Haitham M. A1 - Gissmann, Lutz A1 - Öhlschläger, Peter T1 - Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling) JF - PLOS one N2 - Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism. Y1 - 2014 U6 - http://dx.doi.org/10.1371/journal.pone.0113461 SN - 1932-6203 VL - 11 IS - 9 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Alnemer, Momin Sami Mohammad A1 - Kotliar, Konstantin A1 - Neuhaus, Valentin A1 - Pape, Hans-Christoph A1 - Ciritsis, Bernhard D. T1 - Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model JF - Cost Effectiveness and Resource Allocation N2 - Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare & Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10% fracture risk reduction, model A costs between $8,850 and $46,940 per quality-adjusted life-year ($/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side’s prophylaxis, the patient’s age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between $11,000/QALY and $74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks. KW - Hip fractures KW - Prevention KW - Geriatric KW - Cost-effectiveness KW - Prophylaxis Y1 - 2023 U6 - http://dx.doi.org/10.1186/s12962-023-00482-4 SN - 1478-7547 N1 - Corresponding author: Momin S. Alnemer IS - 21, Article number: 77 PB - Springer Nature ER - TY - JOUR A1 - Alt, Helmut T1 - Entwicklungstendenzen der Sicherheit und der notwendigen Reserveleistung beim Verbundbetrieb der Kraftwerke JF - Elektrizitätswirtschaft Y1 - 1970 SN - 0013-5496 VL - 69 IS - 25 SP - 672 EP - 678 PB - VWEW-Energieverlag CY - Frankfurt/Main ER - TY - JOUR A1 - Alt, Helmut T1 - Digitale Berechnung der Betriebsdiagramme von Hochspannungsleitungen JF - Elektrizitätswirtschaft Y1 - 1972 SN - 0013-5496 VL - 71 IS - 4 SP - 87 EP - 92 PB - VWEW-Energieverlag CY - Frankfurt/Main ER - TY - JOUR A1 - Alt, Helmut T1 - Auswertung von Prüfungsergebnissen auf elektronischen Rechenanlagen JF - Angewandte Informatik Y1 - 1974 SN - 0013-5704 VL - 16 IS - 5 SP - 219 EP - 222 PB - Vieweg CY - Braunschweig ER - TY - JOUR A1 - Alt, Helmut T1 - Tabellenfreie Berechnung der Einkommensteuer mit Hilfe des programmierbaren Taschenrechners JF - Elektrizitätswirtschaft Y1 - 1978 SN - 0013-5496 VL - 77 SP - 486 EP - 489 PB - VWEW-Energieverlag CY - Frankfurt/Main ER - TY - JOUR A1 - Alt, Helmut T1 - Wirtschaftlichkeit von Investitionen JF - Elektrizitätswirtschaft Y1 - 1978 SN - 0013-5496 VL - 77 IS - 3 SP - 73 EP - 76 PB - VWEW-Energieverlag CY - Frankfurt/Main ER - TY - JOUR A1 - Alt, Helmut T1 - Isolierte Freileitungen, ein Betriebsmittel für schwierige Trassenführung JF - Elektrizitätswirtschaft Y1 - 1979 SN - 0013-5496 VL - Jg. 78 IS - H. 10 SP - 250 EP - 256 ER - TY - JOUR A1 - Alt, Helmut T1 - Kurzschlußstromberechnung JF - Elektrizitätswirtschaft Y1 - 1980 SN - 0013-5496 VL - Jg. 79 IS - H. 10 SP - 379 EP - 382 ER - TY - JOUR A1 - Alt, Helmut T1 - Wirtschaftlichkeitsberechnung von Investitionen mit dem programmierbaren Taschenrechner JF - 3 R international : RRR ; Rohre, Rohrleitungsbau, Rohrleitungstransport Y1 - 1981 SN - 0340-3386 VL - Jg. 20 IS - H. 10 SP - 561 EP - 565 ER - TY - JOUR A1 - Alt, Helmut T1 - Statische oder dynamische Wirtschaftlichkeitsberechnung bei Investitionen zur Energieeinsparung JF - Elektrowärme international Edition B: Industrielle Elektrowärme : IEW = Industrial applications of electro-heat : EWI ; Zeitschrift für das gesamte Gebiet der Elektrowärme in Industrie, Gewerbe und Haushalt Y1 - 1982 SN - 0340-3521 VL - Jg. 40 IS - H. 3/4 SP - 166 EP - 172 ER - TY - JOUR A1 - Alt, Helmut T1 - Einsatz programmierbarer Rechner im Sondervertragskundenbereich der Gasversorgung JF - Das Gas- und Wasserfach : Ausgabe Gas, Erdgas : GWF Y1 - 1983 SN - 0016-4909 VL - Bd. 124 IS - H. 9 SP - 468 EP - 471 ER - TY - JOUR A1 - Alt, Helmut T1 - Intervallschalter mit getrennt einstellbarer Pulszeit und Pulszahl JF - Elektronik : Fachmedium für industrielle Anwender und Entwickler Y1 - 1978 SN - 0013-5658 VL - 27 IS - H. 14 SP - 76 PB - WEKA Fachmedien CY - Haar ER - TY - JOUR A1 - Alt, Helmut T1 - Auswertung von Belastungskennlinien JF - Elektrizitätswirtschaft Y1 - 1983 SN - 0013-5496 VL - Bd. 82 SP - 208 EP - 210 ER - TY - JOUR A1 - Alt, Helmut T1 - Vorteilsausgleich durch Versorgungsunternehmen für Ersatzleistungen Dritter JF - Elektrizitätswirtschaft Y1 - 1985 SN - 0013-5496 VL - Jg. 104 SP - 440 EP - 443 ER - TY - JOUR A1 - Alt, Helmut T1 - Wunschphantasie eines eingefleischten Kernenergiegegners : zur Rede von Bundesumweltminister Jürgen Trittin auf dem VDEW-Kongress 2005 "Die Energieversorgung der Zukunft" JF - EW : das Magazin für die Energie-Wirtschaft Y1 - 2005 SN - 0013-5496 N1 - Printausg. in der Bibliothek vorhanden: 23 Z 585 VL - Bd. 104 IS - H. 17/18 SP - 7 ER - TY - JOUR A1 - Alt, Helmut T1 - Versorgungssicherheit und Windenergie : Tatsachen und Fakten statt Mythen und Mysterien JF - EW : das Magazin für die Energie-Wirtschaft Y1 - 2005 SN - 0013-5496 N1 - Printaus. in der Bibliothek vorhanden: 23 Z 585 VL - Bd. 104 IS - H. 25 SP - 42 EP - 45 ER - TY - JOUR A1 - Alt, Helmut T1 - Die Sonne bestimmt zunehmend die Spannung in der Steckdose : Lastflussberechnung einer Photovoltaikeinspeisung JF - EW : das Magazin für die Energie-Wirtschaft Y1 - 2011 SN - 0013-5496 N1 - Printausg. in der Bibliothek vorhanden: 23 Z 585 VL - Bd. 110 IS - H. 17/18 SP - 24 EP - 29 PB - VWEW-Energieverlag CY - Frankfurt, M. ER - TY - JOUR A1 - Alt, Helmut T1 - Spannungs-Blindleistungs-Regelung mit gesteuerten Netzkennlinien JF - Elektrotechnische Zeitschrift : Ausgabe A, Zeitschrift für elektrische Energietechnik : ETZ Y1 - 1976 SN - 0302-265x VL - 97 IS - 7 SP - 441 EP - 446 PB - VDE-Verlag CY - Wuppertal ER - TY - JOUR A1 - Alt, Helmut T1 - Multiplikativ oder additiv? Diskussionsbeitrag zu Preisanpassungsklauseln in der Gaswirtschaft JF - Energiewirtschaftliche Tagesfragen : et ; Zeitschrift für Energiewirtschaft, Recht, Technik und Umwelt Y1 - 1985 SN - 0013-743X VL - Jg. 35 SP - 609 EP - 611 ER - TY - JOUR A1 - Alt, Helmut T1 - Steuersenkungsgesetz-Auswirkungen und Berechnung JF - Elektrizitätswirtschaft Y1 - 1986 SN - 0013-5496 VL - Jg. 85 SP - 238 EP - 242 ER - TY - JOUR A1 - Alt, Helmut T1 - Dialoggesteuerte harmonische Analyse mit dem HP 41 JF - Elektrizitätswirtschaft Y1 - 1986 SN - 0013-5496 VL - Bd. 85 IS - H. 4 SP - 139 EP - 142 ER - TY - JOUR A1 - Alt, Helmut T1 - Dialoggesteuerte harmonische Analyse mit dem HP 41 JF - Elektrowärme international Edition B : Industrielle Elektrowärme : IEW = Industrial applications of electro-heat : EWI ; Zeitschr. für das gesamte Gebiet der Elektrowärme in Industrie, Gewerbe und Haushalt Y1 - 1986 SN - 0340-3521 VL - Jg. 44 IS - H. 6 SP - 283 EP - 287 ER - TY - JOUR A1 - Alt, Helmut T1 - Dialoggesteuerte Spannungs- und Belastungsberechnung im Netz eines Elektrizitätsversorgungsunternehmens JF - Elektrizitätswirtschaft Y1 - 1986 SN - 0013-5496 VL - Bd. 85 IS - H. 23 SP - 906 EP - 910 ER - TY - JOUR A1 - Alt, Helmut T1 - Effektivzinsberechnung bei industriellen oder gewerblichen Tilgungsdarlehen JF - Elektrizitätswirtschaft Y1 - 1987 SN - 0013-5496 VL - Bd. 86 SP - 592 EP - 595 ER - TY - JOUR A1 - Alt, Helmut T1 - Steuerreformgesetz 1990 JF - Elektrizitätswirtschaft Y1 - 1989 SN - 0013-5496 VL - Bd. 88 IS - H. 1/2 SP - 78 EP - 83 ER - TY - JOUR A1 - Alt, Helmut T1 - Steuersenkungs-Erweiterungsgesetz 1988 zur Gesamtentlastung der Einkommensteuer JF - Betriebs-Berater : BB ; Zeitschrift für Recht und Wirtschaft Y1 - 1987 SN - 0340-7918 VL - Vol. 42 IS - H. 32 SP - 2207 EP - 2208 ER - TY - JOUR A1 - Alt, Helmut T1 - Steuerreformgesetz 1990 JF - Elektrizitätswirtschaft Y1 - 1989 SN - 0947-0581 (E-Journal); 0340-7918 (Print) VL - Jg. 88 IS - H. 2 SP - 120 EP - 121 ER - TY - JOUR A1 - Alt, Helmut T1 - Energietarifstruktur in Ostdeutschland JF - Energiewirtschaftliche Tagesfragen : et ; Zeitschrift für Energiewirtschaft, Recht, Technik und Umwelt Y1 - 1990 SN - 0013-743X VL - Bd. 40 IS - H. 11 SP - 782 EP - 788 ER - TY - JOUR A1 - Alt, Helmut T1 - Effektivzins und APR JF - Die Bank : Zeitschrift für Bankpolitik und Bankpraxis Y1 - 1991 SN - 0342-3182 N1 - Printausg. in der Bibliothek vorhanden: 43 Z 227 VL - Jg. 31 IS - H. 4 SP - 230 EP - 231 ER - TY - JOUR A1 - Alt, Helmut T1 - Möglichkeiten der CO2-Minderung "alternativ" betrachtet JF - Etz : Elektrotechnik & Automation Y1 - 1992 SN - 0170-1711 VL - Bd. 113 IS - H. 6-7 SP - 400 ER - TY - JOUR A1 - Alt, Helmut T1 - Netzimpedanz- und Oberschwingungsberechnung in Netzen der öffentlichen Stromversorgung JF - Elektrizitätswirtschaft Y1 - 1995 SN - 0013-5496 VL - Bd. 94 IS - H. 4 SP - 166 EP - 174 ER - TY - JOUR A1 - Alt, Helmut T1 - Netzanschlußmöglichkeiten und energiewirtschaftliche Bewertung von Windkraftanlagen JF - Elektrizitätswirtschaft Y1 - 1995 SN - 0013-5496 VL - Jg. 94 IS - H. 19 SP - 1224 EP - 1234 ER - TY - JOUR A1 - Alt, Helmut T1 - Benchmark der Netznutzungspreise JF - Energiewirtschaftliche Tagesfragen : et ; Zeitschrift für Energiewirtschaft, Recht, Technik und Umwelt Y1 - 2000 SN - 0013-743X VL - Bd. 50 IS - H. 11 SP - 846 EP - 850 ER - TY - JOUR A1 - Alt, Helmut T1 - Die Bedeutung des Effektivzinses in der Finanzwirtschaft JF - Betriebs-Berater : BB : Beil. 14 Finanz-Berater Y1 - 1989 SN - 0340-7926 N1 - Printausg. in der Bibliothek vorhanden: 43 Z 228 SP - 31 EP - 32 ER - TY - JOUR A1 - Alt, Helmut T1 - Einfluß der Kontoführungsmodelle auf den Effektivzins und die Restschuld bei Annuitätendarlehen JF - Betriebs-Berater : BB : Beil. 14 Finanz-Berater Y1 - 1989 SN - 0340-7926 N1 - Printausg. in der Bibliothek vorhanden: 43 Z 228 SP - 32 EP - 37 ER - TY - JOUR A1 - Alt, Helmut T1 - Belieferung von Kunden in fremden Netzgebieten JF - EW : das Magazin für die Energie-Wirtschaft Y1 - 2002 SN - 0013-5496 N1 - Printausg. in der Bibliothek vorhanden: 23 Z 585 VL - Bd. 101 IS - H. 1/2 SP - 26 EP - 35 ER - TY - JOUR A1 - Alt, Helmut T1 - Elektro-Brikett-Zentralspeicherheizung soll die Spitzenlast der EVU schonen JF - Energiewirtschaftliche Tagesfragen Y1 - 1975 SN - 0720-6240 VL - 25 IS - 4 SP - 148 EP - 149 PB - VDE-Verlag CY - Berlin ER - TY - JOUR A1 - Alt, Helmut T1 - Ab 1975 Uranerz aus Rabbit-Lake JF - Energiewirtschaftliche Tagesfragen Y1 - 1974 SN - 0720-6240 VL - 24 IS - 1/2 SP - 34 PB - VDE-Verlag CY - Berlin ER - TY - JOUR A1 - Alt, Helmut T1 - 1,45 Mrd. DM für die Kohlevergasung JF - Energiewirtschaftliche Tagesfragen Y1 - 1974 SN - 0720-6240 VL - 24 IS - 5 SP - 243 EP - 244 PB - VDE-Verlag CY - Berlin ER - TY - JOUR A1 - Alt, Helmut T1 - Renditevergleich zwischen Immobilien und Festverzinslichen JF - Die Bank Y1 - 1992 SN - 0342-3182 IS - H. 2 SP - 91 EP - 92 ER - TY - JOUR A1 - Altay, Okyay A1 - Butenweg, Christoph A1 - Taddei, Francesca T1 - Effektivität von Schwingungsdämpfern bei Windenergieanlagen JF - Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt Y1 - 2013 SN - 1436-4867 (E-Journal); 0005-6650 (Print) N1 - Printausgabe in der Bibliothek Bayernallee vorhanden: 13 Z 049-2013 VL - Band 88 IS - Heft 10 SP - S11 EP - S17 PB - VDI Fachmedien CY - Düsseldorf ER - TY - JOUR A1 - Altherr, Lena A1 - Brötz, Nicolas A1 - Dietrich, Ingo A1 - Gally, Tristan A1 - Geßner, Felix A1 - Kloberdanz, Hermann A1 - Leise, Philipp A1 - Pelz, Peter Franz A1 - Schlemmer, Pia A1 - Schmitt, Andreas T1 - Resilience in mechanical engineering - a concept for controlling uncertainty during design, production and usage phase of load-carrying structures JF - Applied Mechanics and Materials N2 - Resilience as a concept has found its way into different disciplines to describe the ability of an individual or system to withstand and adapt to changes in its environment. In this paper, we provide an overview of the concept in different communities and extend it to the area of mechanical engineering. Furthermore, we present metrics to measure resilience in technical systems and illustrate them by applying them to load-carrying structures. By giving application examples from the Collaborative Research Centre (CRC) 805, we show how the concept of resilience can be used to control uncertainty during different stages of product life. Y1 - 2018 SN - 1662-7482 U6 - http://dx.doi.org/10.4028/www.scientific.net/AMM.885.187 VL - 885 SP - 187 EP - 198 PB - Trans Tech Publications CY - Bäch ER - TY - JOUR A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Lorenz, Ulf A1 - Pelz, Peter F. A1 - Pöttgen, Philipp ED - Lübbecke, Marco ED - Koster, Arie ED - Letmathe, Peter ED - Madlener, Reihard ED - Peis, Britta ED - Walther, Grit T1 - Experimental validation of an enhanced system synthesis approach JF - Operations Research Proceedings 2014 N2 - Planning the layout and operation of a technical system is a common task for an engineer. Typically, the workflow is divided into consecutive stages: First, the engineer designs the layout of the system, with the help of his experience or of heuristic methods. Secondly, he finds a control strategy which is often optimized by simulation. This usually results in a good operating of an unquestioned sys- tem topology. In contrast, we apply Operations Research (OR) methods to find a cost-optimal solution for both stages simultaneously via mixed integer program- ming (MILP). Technical Operations Research (TOR) allows one to find a provable global optimal solution within the model formulation. However, the modeling error due to the abstraction of physical reality remains unknown. We address this ubiq- uitous problem of OR methods by comparing our computational results with mea- surements in a test rig. For a practical test case we compute a topology and control strategy via MILP and verify that the objectives are met up to a deviation of 8.7%. Y1 - 2014 SN - 978-3-319-28695-2 U6 - http://dx.doi.org/10.1007/978-3-319-28697-6_1 PB - Springer CY - Basel ER - TY - JOUR A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Pfetsch, Marc E. A1 - Pelz, Peter F. T1 - Maschinelles Design eines optimalen Getriebes JF - ATZ - Automobiltechnische Zeitschrift N2 - Nahezu 100.000 denkbare Strukturen kann ein Getriebe bei gleicher Funktion aufweisen - je nach Ganganzahl und gefordertem Freiheitsgrad. Mit dem traditionellen Ansatz bei der Entwicklung, einzelne vielversprechende Systemkonfigurationen manuell zu identifizieren und zu vergleichen, können leicht innovative und vor allem kostenminimale Lösungen übersehen werden. Im Rahmen eines Forschungsprojekts hat die TU Darmstadt spezielle Optimierungsmethoden angewendet, um auch bei großen Lösungsräumen zielsicher ein für die individuellen Zielstellungen optimales Layout zu finden. Y1 - 2018 SN - 2192-8800 U6 - http://dx.doi.org/10.1007/s35148-018-0131-3 VL - 120 IS - 10 SP - 72 EP - 77 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Pöttgen, Philipp A1 - Lorenz, Ulf A1 - Pelz, Peter F. ED - Pelz, Peter F. ED - Groche, Peter T1 - Multicriterial optimization of technical systems considering multiple load and availability scenarios JF - Applied Mechanics and Materials N2 - Cheap does not imply cost-effective -- this is rule number one of zeitgeisty system design. The initial investment accounts only for a small portion of the lifecycle costs of a technical system. In fluid systems, about ninety percent of the total costs are caused by other factors like power consumption and maintenance. With modern optimization methods, it is already possible to plan an optimal technical system considering multiple objectives. In this paper, we focus on an often neglected contribution to the lifecycle costs: downtime costs due to spontaneous failures. Consequently, availability becomes an issue. KW - sustainability KW - availability KW - energy efficiency KW - mixed-integer linear programming KW - system synthesis Y1 - 2015 SN - 1660-9336 U6 - http://dx.doi.org/10.4028/www.scientific.net/AMM.807.247 VL - 807 SP - 247 EP - 256 ER - TY - JOUR A1 - Altherr, Lena A1 - Joggerst, Laura A1 - Leise, Philipp A1 - Pfetsch, Marc E. A1 - Schmitt, Andreas A1 - Wendt, Janine T1 - On obligations in the development process of resilient systems with algorithmic design methods JF - Applied Mechanics and Materials N2 - Advanced computational methods are needed both for the design of large systems and to compute high accuracy solutions. Such methods are efficient in computation, but the validation of results is very complex, and highly skilled auditors are needed to verify them. We investigate legal questions concerning obligations in the development phase, especially for technical systems developed using advanced methods. In particular, we consider methods of resilient and robust optimization. With these techniques, high performance solutions can be found, despite a high variety of input parameters. However, given the novelty of these methods, it is uncertain whether legal obligations are being met. The aim of this paper is to discuss if and how the choice of a specific computational method affects the developer’s product liability. The review of legal obligations in this paper is based on German law and focuses on the requirements that must be met during the design and development process. KW - legal obligations KW - product liability KW - design of technical systems KW - optimization KW - resilience Y1 - 2018 SN - 1662-7482 U6 - http://dx.doi.org/10.4028/www.scientific.net/AMM.885.240 VL - 885 IS - 885 SP - 240 EP - 252 PB - Trans Tech Publications CY - Bäch ER - TY - JOUR A1 - Altherr, Lena A1 - Leise, Philipp A1 - Pfetsch, Marc E. A1 - Schmitt, Andreas T1 - Algorithmic design and resilience assessment of energy efficient high-rise water supply systems JF - Applied Mechanics and Materials N2 - High-rise water supply systems provide water flow and suitable pressure in all levels of tall buildings. To design such state-of-the-art systems, the consideration of energy efficiency and the anticipation of component failures are mandatory. In this paper, we use Mixed-Integer Nonlinear Programming to compute an optimal placement of pipes and pumps, as well as an optimal control strategy.Moreover, we consider the resilience of the system to pump failures. A resilient system is able to fulfill a predefined minimum functionality even though components fail or are restricted in their normal usage. We present models to measure and optimize the resilience. To demonstrate our approach, we design and analyze an optimal resilient decentralized water supply system inspired by a real-life hotel building. KW - MINLP KW - Buffering Capacity KW - Uncertainty KW - Water Supply Networks KW - Booster Stations Y1 - 2018 U6 - http://dx.doi.org/10.4028/www.scientific.net/AMM.885.211 SN - 1662-7482 VL - 885 SP - 211 EP - 223 PB - Trans Tech Publications CY - Bäch ER - TY - JOUR A1 - Amin, Rashid A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard A1 - Lazarovici, Philip A1 - Lelkes, Peter I. T1 - Permeability of an In Vitro Model of Blood Brain Barrier (BBB) JF - 13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.] Y1 - 2009 SN - 978-3-540-92841-6 N1 - IFMBE Proceedings ; 23, Track 1 ; ICBME 2008 3–6 December 2008 Singapore SP - 81 EP - 84 ER - TY - JOUR A1 - Anding, Ralf A1 - Tabaza, Ruth A1 - Staat, Manfred A1 - Trenz, Eva A1 - Lohmann, Philipp A1 - Klinge, Uwe A1 - Kirschner-Hermanns, Ruth T1 - Introducing a method of in vitro testing of different anchoring systems used for female incontinence and prolapse surgery JF - BioMed research international Y1 - 2013 SN - 1110-7251 (E-Journal); 2314-6141 (E-Journal); 1110-7243 (Print); 2314-6133 (Print) VL - Vol. 2013 SP - Article ID 401417 ER - TY - JOUR A1 - Angermann, Susanne A1 - Günthner, Roman A1 - Hanssen, Henner A1 - Lorenz, Georg A1 - Braunisch, Matthias C. A1 - Steubl, Dominik A1 - Matschkal, Julia A1 - Kemmner, Stephan A1 - Hausinger, Renate A1 - Block, Zenonas A1 - Haller, Bernhard A1 - Heemann, Uwe A1 - Kotliar, Konstantin A1 - Grimmer, Timo A1 - Schmaderer, Christoph T1 - Cognitive impairment and microvascular function in end-stage renal disease JF - International Journal of Methods in Psychiatric Research (MPR) N2 - Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention. KW - cerebral small vessel disease KW - cognitive impairment KW - dialysis KW - retinal vessels Y1 - 2022 U6 - http://dx.doi.org/10.1002/mpr.1909 SN - 1049-8931 (Print) SN - 1557-0657 (Online) VL - 31 IS - 2 SP - 1 EP - 10 PB - Wiley ER - TY - JOUR A1 - Anik, Sabri T1 - Gespritzte Metallbeschichtungen : Eigenschaften lichtbogengespritzter Stahlschichten in Abhängigkeit von einigen Spritzparametern JF - Technische Rundschau : TR ; das Schweizer Industrie-Magazin Y1 - 1978 SN - 0040-148X VL - 70 IS - 26 SP - 9 EP - 13 PB - Medtrix Group CY - Basel ER - TY - JOUR A1 - Anik, Sabri T1 - Gespritzte Metallschichten : Eigenschaften lichtbogengespritzter Stahlschichten in Abhängigkeit von einigen Spritzparametern JF - Technische Rundschau : TR ; das Schweizer Industrie-Magazin Y1 - 1978 SN - 0040-148X VL - 70 IS - 39 SP - 37 EP - 41 PB - Medtrix Group CY - Basel ER - TY - JOUR A1 - Anik, Sabri A1 - Anik, Salahaddin T1 - Stand der Schweißtechnik in der Türkei JF - Schweißen und Schneiden : Fachzeitschrift für Schweißen und verwandte Verfahren Y1 - 1991 SN - 0036-7184 VL - 43 IS - 3 SP - 142 EP - 145 ER - TY - JOUR A1 - Anik, Sabri A1 - Dagsoez, A. K. T1 - Feinbleche schweißen : die Temperaturverteilung in dünnen Stahlblechplatten beim Lichtbogenschweißen JF - Technische Rundschau : TR ; das Schweizer Industrie-Magazin Y1 - 1971 SN - 0040-148X VL - 63 IS - 9 SP - 57 EP - 59 PB - Medtrix Group CY - Basel ER - TY - JOUR A1 - Anik, Sabri A1 - Frohberg, Martin G. T1 - Thermodynamics and solubility of oxygen in liquid copper-lead alloys at 1200°C from E.M.F. measurements JF - Berichte der Bunsengesellschaft für physikalische Chemie Y1 - 1984 SN - 0940-483X SN - 0005-9021 VL - 88 IS - 8 SP - 707 EP - 710 ER - TY - JOUR A1 - Anik, Sabri A1 - Frohberg, Martin G. T1 - Thermodynamics and solubility of oxygen in liquid bismuth-lead and bismuth-antimony alloys JF - Berichte der Bunsengesellschaft für physikalische Chemie Y1 - 1987 SN - 0940-483X SN - 0005-9021 VL - 91 IS - 7 SP - 790 EP - 794 ER - TY - JOUR A1 - Anik, Sabri A1 - Frohberg, Martin G. T1 - Investigations of the thermodynamics of oxygen and the determination of the miscibility gap in the system copper-oxygen-lead at 12000C JF - Zeitschrift für Metallkunde Y1 - 1984 SN - 0044-3093 VL - 75 IS - 8 SP - 586 EP - 589 ER - TY - JOUR A1 - Anik, Sabri A1 - Frohberg, Martin G. T1 - Investigation of the thermodynamics of oxygen and the determination of phase boundaries in the system copper-oxygen-bismuth at 12000C JF - Zeitschrift für Metallkunde Y1 - 1983 SN - 0044-3093 VL - 74 IS - 8 SP - 530 EP - 534 ER - TY - JOUR A1 - Anik, Sabri A1 - Frohberg, Martin G. T1 - Thermodynamics of oxygen in the copper-antimony system at 1473K JF - Erzmetall : Rohstoffgewinnung, Verarbeitung, Recycling, Umwelttechnik Y1 - 1988 SN - 0044-2658 VL - 41 IS - 10 SP - 498 EP - 501 ER - TY - JOUR A1 - Anik, Sabri A1 - Frohberg, Martin G. A1 - Kapoor, Madan Lal T1 - Untersuchungen zum thermodynamischen Verhalten des Sauerstoffs in Kupfer-Wismut-Schmelzen bei 1200°C JF - Zeitschrift für Physikalische Chemie Y1 - 1982 SN - 0942-9352 VL - 133 IS - 2 SP - 167 EP - 174 ER - TY - JOUR A1 - Anik, Sabri A1 - Frohberg, Martin G. A1 - Kapoor, Madan Lal T1 - Experiments and theoretical considerations on the solution of oxygen in binary metal alloys JF - Berichte der Bunsengesellschaft für physikalische Chemie Y1 - 1983 SN - 0005-9021 SN - 0940-483X VL - 87 IS - 12 SP - 1201 EP - 1204 ER - TY - JOUR A1 - Anik, Sabri A1 - Frohberg, Martin G. A1 - Kapoor, Madan Lal T1 - Prediction of thermodynamic properties of oxygen in binary metallic solvents JF - Zeitschrift für Metallkunde Y1 - 1983 SN - 0044-3093 VL - 74 IS - 6 SP - 372 EP - 375 ER - TY - JOUR A1 - Anik, Sabri A1 - Kapoor, Madan Lal A1 - Frohberg, Martin G. T1 - Thermodynamic behaviour of oxygen in molten substitutional alloy solvents JF - Zeitschrift für Metallkunde Y1 - 1983 SN - 0044-3093 VL - 74 IS - 1 SP - 53 EP - 58 ER - TY - JOUR A1 - Anik, Sabri A1 - Topuz, A. A1 - Tuncel, H. S. T1 - Einfluß der Parameter beim Diffusionsschweißen der Stähle X210Cr12 mit 25 CrMo4 auf die Ausbildung der Bindezone JF - Schweißen und Schneiden : Fachzeitschrift für Schweißen und verwandte Verfahren Y1 - 1992 SN - 0036 VL - 44 IS - 2 SP - 97 EP - 100 ER - TY - JOUR A1 - Anik, Sabri A1 - Topuz, A. A1 - Tuncel, H. S. T1 - Einfluß der Parameter beim Diffusionsschweißen der Stähle X 210 Cr 12 und 25 MoCr 4 auf ihre mechanischen Eigenschaften JF - Schweißen und Schneiden : Fachzeitschrift für Schweißen und verwandte Verfahren Y1 - 1991 SN - 0036-7184 VL - 43 IS - 6 SP - 341 EP - 344 ER - TY - JOUR A1 - Anik, Sabri A1 - Tuelbentci, K. T1 - Lichtbogenschweißen : Untersuchung der Schweißschlacke und der Wirkungen auf das Entfernen der Schlacke beim Lichtbogenschweißen ; Teil 1 JF - Technische Rundschau : TR ; das Schweizer Industrie-Magazin Y1 - 1973 SN - 0040-148X VL - 65 IS - 48 SP - 13 EP - 15 PB - Medtrix Group CY - Basel ER - TY - JOUR A1 - Anik, Sabri A1 - Tuelbentci, K. T1 - Lichtbogenschweißen : Untersuchung der Schweißschlacke und der Wirkungen auf das Entfernen der Schlacke ; Teil 2 JF - Technische Rundschau : TR ; das Schweizer Industrie-Magazin Y1 - 1973 SN - 0040-148X VL - 65 IS - 52 SP - 9 EP - 13 PB - Medtrix Group CY - Basel ER - TY - JOUR A1 - Anik, Sabri A1 - Tuelbentci, K. T1 - Lichtbogenschweißen : Untersuchung der Schweißschlacke und der Wirkungen auf das Entfernen der Schlacke ; Teil 3 JF - Technische Rundschau : TR ; das Schweizer Industrie-Magazin Y1 - 1974 SN - 0040-148X VL - 66 IS - 2 SP - 43 EP - 47 PB - Medtrix Group CY - Basel ER - TY - JOUR A1 - Arampatzis, Adamantios A1 - Karamanidis, Kiros A1 - Albracht, Kirsten T1 - Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude JF - Journal of Experimental Biology Y1 - 2007 U6 - http://dx.doi.org/10.1242/jeb.003814 SN - 0022-0949 VL - 210 IS - 15 SP - 2743 EP - 2753 ER - TY - JOUR A1 - Arampatzis, Adamantios A1 - Karamanidis, Kiros A1 - Mademli, Lida A1 - Albracht, Kirsten T1 - Plasticity of the human tendon to short and long-term mechanical loading JF - Exercise and Sport Sciences Reviews Y1 - 2009 U6 - http://dx.doi.org/10.1097/JES.0b013e31819c2e1d SN - 1538-3008 VL - 37 IS - 2 SP - 66 EP - 72 ER -